CN1792359A - Water soluble fluoridized foam, and its prepn. method - Google Patents
Water soluble fluoridized foam, and its prepn. method Download PDFInfo
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- CN1792359A CN1792359A CN 200510090736 CN200510090736A CN1792359A CN 1792359 A CN1792359 A CN 1792359A CN 200510090736 CN200510090736 CN 200510090736 CN 200510090736 A CN200510090736 A CN 200510090736A CN 1792359 A CN1792359 A CN 1792359A
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Abstract
A water-soluble fluoride foam for preventing and treating decayed tooth contains foaming agent, humectant, thickening agent, acidifying agent, water-soluble fluoride, sweetening agent, essence, propellant, and distilled water. The content of F ions is 5000-9700 ppm or 12300-17000 ppm for different purposes.
Description
Technical field
The present invention relates to a kind of fluoration foam, refer more particularly to water soluble fluoridized foam and manufacture method in a kind of treatment that is applied to dentistry.
Background technology
In recent years, fluoride is applied in the treatment of dentistry, and fluorine can combine with tooth crystal structure-hydroxyapatite, makes its remineralization and changes tooth lenticular structure, resists acid etching, prevents dental caries.
Dental caries is an a kind of tooth section frequently-occurring disease, reached more than 90% according to the present child's sickness rate of statistics China, at present, multiple fluoride has been applied to the treatment (as sodium fluoride sodium monofluorophosphate acid phosphatase fluorine etc.) of dental caries, and be made into gel, collutory, toothpaste, dentifrice etc., be applied to local preventing decayed tooth.But because the limitation of these products, the fluorion in the fluoride does not reach maximum free state, influences adamantine absorption and exchange, and effect is undesirable, and causes the waste of human and material resources;
In recent years, China's use contains the fluoride in caries prevention product and carries out colony's preventing and controlling in large area, and it uses security of products more and more to cause people's attention.According to the national conditions of China, two principles should be followed with fluorine in the part, and one is the fluorine-containing product that the stomatological medical personnel use.Another is suitable for China's actual conditions, the fluorine-containing product that in colony's prevention, can use safely, this product can be by personnel or the user oneself operation through training. because this product exists with foam state, its use amount is 1/5 of the identical fluorine-containing product of other concentration, can effectively reduce the absorption of human body like this to fluoride, reduce the probability of fluoride poisoning, use is felt more relieved.So will be at above demand, demand urgently developing-kind except that fluoration foam product that need to instruct the fluoration foam of its concentration at 12300PPM-17000PPM of use, also will develop its fluorine concentration of being suitable for using safely in colony prevention the stomatological medical personnel be 5000PPM-9700PPM.
Summary of the invention
The object of the present invention is to provide that a kind of safe in utilization, easy to operate, anticaries action is lasting, the obvious results water soluble fluoridized foam.
The present invention adopts following technological means to realize:
A kind of water soluble fluoridized foam wherein contains foaming agent, the adhesion agent of preserving moisture, acidulant, soluble fluoride, sweeting agent and essence, propellant and distilled water; Be equipped with water soluble fluoridized foam in the aerosol container, extrude the fine and smooth cystose of back product shows white, do not have flowability, pH value is 3.0～3.8; According to different use character, content of fluoride ion is divided into 5000-9700ppm and two scopes of 12300-17000ppm, and wherein: the content of sodium fluoride is 1.0wt%-1.53wt%; 2.09wt%-2.8wt%; The content of foaming agent is 8wt%-13wt%; The content of adhesion agent of preserving moisture is 13wt%-14wt%: acidulant content be 1.5wt%-1.6wt%: the content of sweeting agent and essence is 1.5wt%-1.6wt%: the content of propellant is 5wt%-7wt%: all the other are added into wt100% for distilled water.
Aforesaid infusion is a foam dense, stable, that do not have flowability, and meets acid and stablize; Mixture for Tween-60, platinum Luo Shamu, sodium lauryl sulphate.
The aforesaid adhesion agent of preserving moisture is glycerol, the third methylcellulose mixture.
Aforesaid acidulant is phosphoric acid, citric acid, malic acid mixture.
A kind of manufacture method of water soluble fluoridized foam is:
Step 1, press formula proportion with beaker with the accurate weighing of each raw material, stand-by;
Step 2, respectively component one and component two are joined in the agitated kettle, turn on agitator also is warming up to 90 ℃;
Step 3, when after the temperature constant component three being joined in the agitated kettle in batches, constant temperature stirs to be clarified up to solution in 60-80 minute;
Step 4, after solution clarification, open condensation water for cooling to 70 ℃, added component nine, ten, 11 in every interval 10-20 minute one by one;
Step 5, continue to open condensation water for cooling to 60 ℃, component five is joined in the agitated kettle in batches, constant temperature stirs to be clarified up to solution in 50-60 minute;
Step 6, gradation slowly adds component eight, component 12 and component seven under constant temperature stirs, and continues to stir and clarifies to solution in 30-50 minute;
Step 7, open condensation water for cooling to 45 ℃ once more, add component 13 and stir and make it fully that the dissolving back adds component six fast in the solution center, continue to stir 20-30 minute;
Step 8, when being cooled to 25-30 ℃, solution stops to stir;
Step 9, above-mentioned solution is poured in the aerosol container for preparing in advance, add the 5-7wt% aerosol behind the capping valve, aerosol adopts propane, iso-butane gaseous mixture, and ratio is 20% propane+80% iso-butane or 15% propane+85% iso-butane; Air pressure is 0.35～0.45mpa, and the nozzle that configuration is fit to sprays water soluble fluoridized foam uniformly..
The present invention compares with utility model has remarkable advantages and beneficial effect:
Water soluble fluoridized foam of the present invention and manufacture method, this water soluble fluoridized foam is extruded the fine and smooth cystose of back product shows white, is not had flowability, and pH value is 3.0～3.8; According to different use character, content of fluoride ion is divided into 5000-9700ppm and two scopes of 12300-17000ppm, and wherein the content of sodium fluoride is 1.0wt%-1.53wt%; 2.09wt%-2.8wt%; Guaranteed the rational and effective fluorine dosage of product, made fluorion reach maximum diffusion and dissociate that help absorption and the exchange of enamel for fluorion, the anti-caries effect is remarkable.Because this product exists with foam state, its use amount is the identical fluorine-containing products 1/5 of other concentration, uses safelyr, is particularly suitable for colony's prevention use of dental caries district occurred frequently and dental caries group of people at high risk.
The specific embodiment
Below to embodiments of the present invention, detailed in addition explanation;
The present invention is a kind of to be applied to water soluble fluoridized foam in the treatment of dentistry, wherein contains foaming agent, the adhesion agent of preserving moisture, acidulant, soluble fluoride, sweeting agent and essence, propellant and distilled water.Be equipped with water soluble fluoridized foam in the aerosol container, extrude the fine and smooth cystose of back product shows white, do not have flowability, pH value is 3.0～3.8; According to different use character, content of fluoride ion is divided into 5000-9700ppm and two scopes of 12300-17000ppm; Wherein the content of mentioned component is as follows:
1, the content 1.0wt%-1.53wt% of sodium fluoride; 2.09wt%-2.8wt%
2, be applicable in the oral cavity, meet stable foaming agent (Tween-60, platinum Luo Shamu, sodium lauryl sulphate) the content 8wt%-13wt% of acid;
3, be applicable in the oral cavity, meet the stable adhesion agent of preserving moisture (glycerol, third methylcellulose) the content 13wt%-14wt%4 of acid:
4, be applicable to intraoral acidulant (phosphoric acid, citric acid, malic acid) content wt%1.5-1.6wt%
5, an amount of flavoring agent (aspartame, essence) content 1.5wt%-1.6wt%
6, appropriate amount of propellant (propane butane gaseous mixture) content wt%5-7wt%
7, proper amount of deionized water (distilled water) is added into wt 100%.
The manufacture method of the water soluble fluoridized foam in a kind of treatment that is applied to dentistry is divided into following steps:
Press formula proportion with beaker with the accurate weighing of each raw material, stand-by; Respectively component one and component two are joined in the agitated kettle, turn on agitator also is warming up to 90 ℃; When after the temperature constant component three being joined in the agitated kettle in batches, constant temperature stirs to be clarified up to solution in 60-80 minute; After solution clarification, open condensation water for cooling to 70 ℃, added component nine, ten, 11 in every interval 10-20 minute one by one; Continue to open condensation water for cooling to 60 ℃, component five is joined in the agitated kettle in batches, constant temperature stirs to be clarified up to solution in 50-60 minute;
Gradation slowly adds component eight, component 12 and component seven under constant temperature stirs, and continues to stir and clarifies to solution in 30-50 minute; Open condensation water for cooling to 45 ℃ once more, add component 13 and stir and make it fully that the dissolving back adds component six fast in the solution center, continue to stir 20-30 minute; When being cooled to 25-30 ℃, solution stops to stir;
Above-mentioned solution is poured in the aerosol container for preparing in advance, add the 5-7wt% aerosol behind the capping valve, aerosol adopts propane, iso-butane gaseous mixture, and ratio is 20% propane+80% iso-butane or 15% propane+85% iso-butane; Air pressure is 0.35-0.45mpa, and the nozzle that configuration is fit to sprays water soluble fluoridized foam uniformly.
The different component data that four embodiment are divided into see also shown in the following table below:
Fluoration foam proportioning embodiment 1
| Number of components | Percentage by weight | Composition | Remarks |
| Component one | 63.19447 | Moisture content | |
| Component two | 13.00000 | Glycerol | |
| Component three | 8.00000 | Foaming agent | |
| Component four | 6.50000 | The propane butane gaseous mixture | |
| Component five | 5.00000 | Foaming agent | |
| Component six | 1.10000 | Essence | |
| Component seven | 1.02000 | Sodium fluoride | |
| Component eight | 0.86553 | Acidulant | |
| Component nine | 0.50000 | Sweeting agent | |
| Component ten | 0.40000 | Acidulant, | |
| Component 11 | 0.30000 | Acidulant | |
| Component 12 | 0.07000 | HF | |
| Component 13: | 0.05000 | Sodium benzoate | |
| Add up to | 100.00000 |
Fluoration foam proportioning embodiment 2
| Number of components | Percentage by weight | Composition | Remarks |
| Component one | 62.67447 | Moisture content | |
| Component two | 13.00000 | Glycerol | |
| Component two | 8.00000 | Foaming agent | |
| Component four | 6.50000 | The propane butane gaseous mixture | |
| Component five | 5.00000 | Foaming agent | |
| Component six | 1.10000 | Essence | |
| Component seven | 1.53000 | Sodium fluoride | |
| Component eight | 0.86553 | Acidulant | |
| Component nine | 0.50000 | Sweeting agent | |
| Component ten | 0.40000 | Acidulant, | |
| Component 11 | 0.30000 | Acidulant | |
| Component 12 | 0.07000 | HF | |
| Component 12: | 0.05000 | Sodium benzoate | |
| Add up to | 100.00000 |
Fluoration foam proportioning embodiment 3
| Number of components | Percentage by weight | Composition | Remarks |
| Component one | 62.00447 | Moisture content | |
| Component two | 13.00000 | Glycerol | |
| Component three | 8.00000 | Foaming agent | |
| Component four | 6.50000 | The propane butane gaseous mixture | |
| Component five | 5.00000 | Foaming agent | |
| Component six | 1.10000 | Essence | |
| Component seven | 2.21000 | Sodium fluoride | |
| Component eight | 0.86553 | Acidulant | |
| Component nine | 0.50000 | Sweeting agent | |
| Component ten | 0.40000 | Acidulant, | |
| Component 11 | 0.30000 | Acidulant | |
| Component 12 | 0.07000 | HF | |
| Component 13: | 0.05000 | Sodium benzoate | |
| Add up to | 100.00000 |
Fluoration foam proportioning embodiment 4
| Number of components | Percentage by weight | Composition | Remarks |
| Component one | 61.32447 | Moisture content | |
| Component two | 13.00000 | Glycerol | |
| Component three | 8.00000 | Foaming agent | |
| Component four | 6.50000 | The propane butane gaseous mixture | |
| Component five | 5.00000 | Foaming agent | |
| Component six | 1.10000 | Essence | |
| Component seven | 2.89000 | Sodium fluoride | |
| Component eight | 0.86553 | Acidulant | |
| Component nine | 0.50000 | Sweeting agent | |
| Component ten | 0.40000 | Acidulant, | |
| Component 11 | 0.30000 | Acidulant | |
| Component 12 | 0.07000 | HF | |
| Component 13: | 0.05000 | Sodium benzoate | |
| Add up to | 100.00000 |
To there be the fluoration foam composition of pressure to clamp-on in the purpose-made pallet groove in use at first from container; make it in tray slot; extrude fluoration foam then to the purpose-made pallet groove; place in the oral cavity; bite with tooth; kept 1～4 minute, fluoration foam can make each tooth can both take in the ion fluorine effectively, safely, thereby takes care of one's teeth.
Though it is pointed out that the content of the sodium fluoride of water soluble fluoridized foam of the present invention is 1.0wt%-1.53wt% and 2.09wt%-2.8wt%; Because though fluorine concentration has certain curative effect when reaching 12300ppm but must instruct use by the stomatological medical doctor, though and fluorine concentration is suitable for teenager when being lower than 12300ppm and healthy population uses, also must use according to the description of this patent product.
It should be noted that at last: above embodiment only in order to the explanation the present invention and and unrestricted technical scheme described in the invention; Therefore, although this description has been described in detail the present invention with reference to each above-mentioned embodiment,, those of ordinary skill in the art should be appreciated that still and can make amendment or be equal to replacement the present invention; And all do not break away from the technical scheme and the improvement thereof of the spirit and scope of the present invention, and it all should be encompassed in the claim scope of the present invention.
Claims (5)
1, a kind of water soluble fluoridized foam wherein contains foaming agent, the adhesion agent of preserving moisture, acidulant, soluble fluoride, sweeting agent and essence, propellant and distilled water; It is characterized in that:
Be equipped with water soluble fluoridized foam in the aerosol container, extrude the fine and smooth cystose of back product shows white, do not have flowability, pH value is 3.0～3.8; According to different use character, content of fluoride ion is divided into 5000-9700ppm and two scopes of 12300-17000ppm, wherein:
The content of described sodium fluoride is 1.0wt%-1.53wt%; 2.09wt%-2.8wt%;
The content of described foaming agent is 8wt%-13wt%;
The content of the described adhesion agent of preserving moisture is 13wt%-14wt%:
Described acidulant content be 1.5wt%-1.6wt%:
The content of described sweeting agent and essence is 1.5wt%-1.6wt%:
The content of described propellant is 5wt%-7wt%:
All the other are added into 100% for distilled water.
2, water soluble fluoridized foam according to claim 1 is characterized in that described infusion is a foam dense, stable, that do not have flowability, and meets acid and stablize; Mixture for Tween-60, platinum Luo Shamu, sodium lauryl sulphate.
3, water soluble fluoridized foam according to claim 1 is characterized in that the described adhesion agent of preserving moisture is glycerol, the third methylcellulose mixture.
4, water soluble fluoridized foam according to claim 1 is characterized in that described acidulant is phosphoric acid, citric acid, malic acid mixture.
5, the manufacture method of water soluble fluoridized foam is characterized in that manufacturing step is:
Step 1, press formula proportion with beaker with the accurate weighing of each raw material, stand-by;
Step 2, respectively component one and component two are joined in the agitated kettle, turn on agitator also is warming up to 90 ℃;
Step 3, when after the temperature constant component three being joined in the agitated kettle in batches, constant temperature stirs to be clarified up to solution in 60-80 minute;
Step 4, after solution clarification, open condensation water for cooling to 70 ℃, added component nine, ten, 11 in every interval 10-20 minute one by one;
Step 5, continue to open condensation water for cooling to 60 ℃, component five is joined in the agitated kettle in batches, constant temperature stirs to be clarified up to solution in 50-60 minute;
Step 6, gradation slowly adds component eight, component 12 and component seven under constant temperature stirs, and continues to stir and clarifies to solution in 30-50 minute;
Step 7, open condensation water for cooling to 45 ℃ once more, add component 13 and stir and make it fully that the dissolving back adds component six fast in the solution center, continue to stir 20-30 minute;
Step 8, when being cooled to 25-30 ℃, solution stops to stir;
Step 9, above-mentioned solution is poured in the aerosol container for preparing in advance, add the 5-7wt% aerosol behind the capping valve, aerosol adopts propane, iso-butane gaseous mixture, and ratio is 20% propane+80% iso-butane or 15% propane+85% iso-butane; Air pressure is 0.35～0.45mpa, and the nozzle that configuration is fit to sprays water soluble fluoridized foam uniformly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510090736 CN1792359A (en) | 2005-08-15 | 2005-08-15 | Water soluble fluoridized foam, and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510090736 CN1792359A (en) | 2005-08-15 | 2005-08-15 | Water soluble fluoridized foam, and its prepn. method |
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| Publication Number | Publication Date |
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| CN1792359A true CN1792359A (en) | 2006-06-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200510090736 Pending CN1792359A (en) | 2005-08-15 | 2005-08-15 | Water soluble fluoridized foam, and its prepn. method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859765A (en) * | 2019-12-17 | 2020-03-06 | 北京天一恒康医疗器械有限公司 | Fluorinated foam for preventing dental caries |
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2005
- 2005-08-15 CN CN 200510090736 patent/CN1792359A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859765A (en) * | 2019-12-17 | 2020-03-06 | 北京天一恒康医疗器械有限公司 | Fluorinated foam for preventing dental caries |
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