CN111686035A - Bio-enzyme antibacterial anti-allergy toothpaste - Google Patents
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Abstract
The invention discloses a bio-enzyme antibacterial and anti-allergic toothpaste, which comprises 15-17% of sorbitol, 2.1-3.4% of glycerol, 1-5% of polyethylene glycol-400, 1-4% of xylitol, 0.1-0.2% of sucralose, 0.3-0.8% of cellulose gum, 1.1-1.4% of sodium lauroyl sarcosinate, 3.2-3.5% of cocamidopropyl betaine, 0.1-0.8% of tetrasodium pyrophosphate, 0.5-0.8% of sodium benzoate, 1.0-1.5% of edible essence, 0.1-0.3% of strontium chloride, 0.01-0.1% of dipotassium glycyrrhizinate, 0.001-0.02% of lysozyme, 0.001-0.02% of histidine, 0.001-0.02% of glycine and the balance of deionized water. The biological enzyme antibacterial and anti-allergy toothpaste disclosed by the invention is healthy and convenient, realizes quick air bubble and tooth cleaning, and effectively relieves the sensitivity of teeth.
Description
Technical Field
The invention relates to the technical field of toothpaste, in particular to bio-enzyme antibacterial and anti-allergy toothpaste.
Background
Toothpaste is a common cleaning product in daily life and has a long history. The existing toothpaste is paste toothpaste with certain thickness, and the effect of cleaning teeth can be realized only by matching with a toothbrush for use and brushing for a certain time. With the acceleration of life rhythm, the time of brushing teeth of people can not be ensured, and the health of the oral cavity is influenced. However, the existing mousse type toothpastes do not effectively remove oral bacteria. In addition, for sensitive teeth, a toothbrush is often used for brushing teeth to stimulate the teeth, so that the treatment effect is influenced.
Disclosure of Invention
The invention aims to provide the bio-enzyme antibacterial anti-allergy toothpaste which is healthy and convenient, realizes quick air bubble and tooth cleaning, and effectively relieves the sensitivity of teeth.
In order to achieve the purpose, the invention provides biological enzyme antibacterial and anti-allergy toothpaste, which comprises 15-17% of sorbitol, 2.1-3.4% of glycerol, 1-5% of polyethylene glycol-400, 1-4% of xylitol, 0.1-0.2% of sucralose, 0.3-0.8% of cellulose gum, 1.1-1.4% of sodium lauroyl sarcosinate, 3.2-3.5% of cocamidopropyl betaine, 0.1-0.8% of tetrasodium pyrophosphate, 0.5-0.8% of sodium benzoate, 1.0-1.5% of edible essence, 0.1-0.3% of strontium chloride, 0.01-0.1% of dipotassium glycyrrhizinate, 0.001-0.02% of lysozyme, 0.001-0.02% of histidine, 0.001-0.02% of glycine and the balance of deionized water.
Preferably, the components and the proportion of the toothpaste comprise 15% of sorbitol, 3.0% of glycerol, 2% of polyethylene glycol-400, 3% of xylitol, 0.1% of sucralose, 0.8% of cellulose gum, 1.4% of sodium lauroyl sarcosine, 3.5% of cocamidopropyl betaine, 0.7% of tetrasodium pyrophosphate, 0.5% of sodium benzoate, 1.4% of edible essence, 0.3% of strontium chloride, 0.09% of dipotassium glycyrrhizinate, 0.001% of lysozyme, 0.001% of histidine, 0.0017% of glycine and the balance of deionized water.
Preferably, the components and the proportion of the toothpaste comprise 16.8 percent of sorbitol, 2.2 percent of glycerin, 4.8 percent of polyethylene glycol-400, 2 percent of xylitol, 0.2 percent of sucralose, 0.3 percent of cellulose gum, 1.1 percent of sodium lauroyl sarcosine, 3.2 percent of cocamidopropyl betaine, 0.2 percent of tetrasodium pyrophosphate, 0.7 percent of sodium benzoate, 1.3 percent of edible essence, 0.2 percent of strontium chloride, 0.04 percent of dipotassium glycyrrhizinate, 0.02 percent of lysozyme, 0.02 percent of histidine, 0.005 percent of glycine and the balance of deionized water.
Preferably, the components and the proportion of the toothpaste comprise 15.1 percent of sorbitol, 3.3 percent of glycerin, 1.2 percent of polyethylene glycol-400, 1 percent of xylitol, 0.2 percent of sucralose, 0.5 percent of cellulose gum, 1.2 percent of sodium lauroyl sarcosine, 3.3 percent of cocamidopropyl betaine, 0.5 percent of tetrasodium pyrophosphate, 0.6 percent of sodium benzoate, 1.1 percent of edible essence, 0.2 percent of strontium chloride, 0.08 percent of dipotassium glycyrrhizinate, 0.02 percent of lysozyme, 0.005 percent of histidine, 0.002 percent of glycine and the balance of deionized water.
A preparation method of bio-enzyme antibacterial anti-allergy toothpaste comprises the following steps:
s1, adding xylitol, sucralose, sodium lauroyl sarcosinate, cocamidopropyl betaine, tetrasodium pyrophosphate, sodium benzoate, strontium chloride and dipotassium glycyrrhizinate into 3/4 water, heating and stirring to dissolve to obtain a solution a;
s2, weighing sorbitol, glycerol and polyethylene glycol-400, mixing, adding cellulose gum, and mixing to obtain glue b with consistency;
s3, weighing lysozyme, histidine and glycine, adding the lysozyme, the histidine and the glycine into 1/4 water, and stirring and dissolving to obtain a solution c;
and S4, adding the solution a into the glue b, stirring for 30min, adding the solution c, continuing stirring for 10min, standing for 12h, and filling.
Therefore, the bio-enzyme antibacterial and anti-allergy toothpaste disclosed by the invention is healthy and convenient, realizes quick air bubble and tooth cleaning, and effectively relieves the sensitivity of teeth.
According to the invention, the amino acid surfactant sodium lauroyl sarcosinate and the amphoteric surfactant cocoamidopropyl betaine are compounded, so that the foam is finer and smoother, and the foam is refined by promoting foaming, so that the foam is more durable. In addition, the cleaning of teeth is accelerated by matching lysozyme, anti-sensitive components of strontium chloride and dipotassium glycyrrhizinate are added to relieve dentin sensitivity symptoms, amino acid provides nutrient substances for gingiva, and the problem that toothpaste is insoluble in water and effective components cannot play a role quickly is solved.
The technical solution of the present invention is further described in detail by the following examples.
Detailed Description
The embodiments of the present invention will be further explained below.
A biological enzyme antibacterial and antiallergic toothpaste comprises 15-17% sorbitol, 2.1-3.4% glycerol, 1-5% polyethylene glycol-400, 1-4% xylitol, 0.1-0.2% sucralose, 0.3-0.8% cellulose gum, 1.1-1.4% sodium lauroyl sarcosine, 3.2-3.5% cocamidopropyl betaine, 0.1-0.8% tetrasodium pyrophosphate, 0.5-0.8% sodium benzoate, 1.0-1.5% edible essence, 0.1-0.3% strontium chloride, 0.01-0.1% dipotassium glycyrrhizinate, 0.001-0.02% lysozyme, 0.001-0.02% histidine, 0.001-0.02% glycine, and the balance deionized water.
A preparation method of bio-enzyme antibacterial anti-allergy toothpaste comprises the following steps:
s1, adding xylitol, sucralose, sodium lauroyl sarcosinate, cocamidopropyl betaine, tetrasodium pyrophosphate, sodium benzoate, strontium chloride and dipotassium glycyrrhizinate into 3/4 water, heating and stirring to dissolve to obtain a solution a;
s2, weighing sorbitol, glycerol and polyethylene glycol-400, mixing, adding cellulose gum, and mixing to obtain glue b with consistency;
s3, weighing lysozyme, histidine and glycine, adding the lysozyme, the histidine and the glycine into 1/4 water, and stirring and dissolving to obtain a solution c;
and S4, adding the solution a into the glue b, stirring for 30min, adding the solution c, continuing stirring for 10min, standing for 12h, and filling.
Example one
The components and the proportion of the toothpaste comprise 15 percent of sorbitol, 3.0 percent of glycerin, 2 percent of polyethylene glycol-400, 3 percent of xylitol, 0.1 percent of sucralose, 0.8 percent of cellulose gum, 1.4 percent of sodium lauroyl sarcosine, 3.5 percent of cocamidopropyl betaine, 0.7 percent of tetrasodium pyrophosphate, 0.5 percent of sodium benzoate, 1.4 percent of edible essence, 0.3 percent of strontium chloride, 0.09 percent of dipotassium glycyrrhizinate, 0.001 percent of lysozyme, 0.001 percent of histidine, 0.0017 percent of glycine and the balance of deionized water.
Example two
The components and the proportion of the toothpaste comprise 16.8 percent of sorbitol, 2.2 percent of glycerin, 4.8 percent of polyethylene glycol-400, 2 percent of xylitol, 0.2 percent of sucralose, 0.3 percent of cellulose gum, 1.1 percent of sodium lauroyl sarcosine, 3.2 percent of cocamidopropyl betaine, 0.2 percent of tetrasodium pyrophosphate, 0.7 percent of sodium benzoate, 1.3 percent of edible essence, 0.2 percent of strontium chloride, 0.04 percent of dipotassium glycyrrhizinate, 0.02 percent of lysozyme, 0.02 percent of histidine, 0.005 percent of glycine and the balance of deionized water.
EXAMPLE III
The components and the proportion of the toothpaste comprise 15.1 percent of sorbitol, 3.3 percent of glycerin, 1.2 percent of polyethylene glycol-400, 1 percent of xylitol, 0.2 percent of sucralose, 0.5 percent of cellulose gum, 1.2 percent of sodium lauroyl sarcosine, 3.3 percent of cocamidopropyl betaine, 0.5 percent of tetrasodium pyrophosphate, 0.6 percent of sodium benzoate, 1.1 percent of edible essence, 0.2 percent of strontium chloride, 0.08 percent of dipotassium glycyrrhizinate, 0.02 percent of lysozyme, 0.005 percent of histidine, 0.002 percent of glycine and the balance of deionized water.
Test of
(1) 100 healthy, 18-65 years old, sensitive teeth were randomly divided into two groups, one group using a regular anti-sensitivity foaming toothpaste and two groups using a toothpaste according to the formulation of example one.
When in use, the toothpaste foam is discharged from the pressure nozzle by aiming at the oral cavity and pressing for 3-5 times every day, the dosage is 0.5-1.0ml each time, the mouth is rinsed for 30s, so that the foam is fully contacted with the inside of the oral cavity, and then the foam is spitted out, and the mouth is rinsed twice, at least 30s each time. After eight weeks of use, the insufflation stimulation was performed by cold air, and the results were as follows.
| A group of | Two groups are | |
| No response to air stimulation | 24 | 39 |
| Respond to air stimulation but are acceptable | 12 | 9 |
| Responsive to air stimulation, but requesting cessation | 13 | 2 |
| Response to air irritation and intolerable pain | 1 | 0 |
(2) 100 healthy, 18-65 years old people were randomly divided into two groups, one group using regular toothpaste and two groups using the toothpaste formulated in example one.
When in use, the toothpaste foam is discharged from the pressure nozzle by aiming at the oral cavity and pressing for 3-5 times every day, the dosage is 0.5-1.0ml each time, the mouth is rinsed for 30s, so that the foam is fully contacted with the inside of the oral cavity, and then the foam is spitted out, and the mouth is rinsed twice, at least 30s each time.
After eight weeks of use, saliva was collected from one and two groups of subjects, diluted with PBS, 0.2ml of the saliva was spread on BHIA plates, cultured anaerobically at 37 ℃ for 72 hours for bacterial enumeration, and 3 replicates per group were performed, as follows.
| Group of | Average viable bacteria count |
| A group of | 2.0*105 |
| Two groups are | 2.3*103 |
The data show that the toothpaste has an obvious sterilization effect and can effectively relieve the sensitivity of teeth.
Therefore, the bio-enzyme antibacterial and anti-allergy toothpaste disclosed by the invention is healthy and convenient, realizes quick air bubble and tooth cleaning, and effectively relieves the sensitivity of teeth.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that modifications can be made by those skilled in the art without departing from the principle of the present invention, and these modifications should also be construed as the protection scope of the present invention.
Claims (5)
1. A bio-enzyme antibacterial anti-allergy toothpaste is characterized in that: the components and the proportion of the toothpaste comprise 15-17% of sorbitol, 2.1-3.4% of glycerol, 1-5% of polyethylene glycol-400, 1-4% of xylitol, 0.1-0.2% of sucralose, 0.3-0.8% of cellulose gum, 1.1-1.4% of sodium lauroyl sarcosine, 3.2-3.5% of cocamidopropyl betaine, 0.1-0.8% of tetrasodium pyrophosphate, 0.5-0.8% of sodium benzoate, 1.0-1.5% of edible essence, 0.1-0.3% of strontium chloride, 0.01-0.1% of dipotassium glycyrrhizinate, 0.001-0.02% of lysozyme, 0.001-0.02% of histidine, 0.001-0.02% of glycine and the balance of deionized water.
2. The bio-enzyme bacteriostatic and anti-allergic toothpaste according to claim 1, which is characterized in that: the components and the proportion of the toothpaste comprise 15 percent of sorbitol, 3.0 percent of glycerin, 2 percent of polyethylene glycol-400, 3 percent of xylitol, 0.1 percent of sucralose, 0.8 percent of cellulose gum, 1.4 percent of sodium lauroyl sarcosine, 3.5 percent of cocamidopropyl betaine, 0.7 percent of tetrasodium pyrophosphate, 0.5 percent of sodium benzoate, 1.4 percent of edible essence, 0.3 percent of strontium chloride, 0.09 percent of dipotassium glycyrrhizinate, 0.001 percent of lysozyme, 0.001 percent of histidine, 0.0017 percent of glycine and the balance of deionized water.
3. The bio-enzyme bacteriostatic and anti-allergic toothpaste according to claim 1, which is characterized in that: the components and the proportion of the toothpaste comprise 16.8 percent of sorbitol, 2.2 percent of glycerin, 4.8 percent of polyethylene glycol-400, 2 percent of xylitol, 0.2 percent of sucralose, 0.3 percent of cellulose gum, 1.1 percent of sodium lauroyl sarcosine, 3.2 percent of cocamidopropyl betaine, 0.2 percent of tetrasodium pyrophosphate, 0.7 percent of sodium benzoate, 1.3 percent of edible essence, 0.2 percent of strontium chloride, 0.04 percent of dipotassium glycyrrhizinate, 0.02 percent of lysozyme, 0.02 percent of histidine, 0.005 percent of glycine and the balance of deionized water.
4. The bio-enzyme bacteriostatic and anti-allergic toothpaste according to claim 1, which is characterized in that: the components and the proportion of the toothpaste comprise 15.1 percent of sorbitol, 3.3 percent of glycerin, 1.2 percent of polyethylene glycol-400, 1 percent of xylitol, 0.2 percent of sucralose, 0.5 percent of cellulose gum, 1.2 percent of sodium lauroyl sarcosine, 3.3 percent of cocamidopropyl betaine, 0.5 percent of tetrasodium pyrophosphate, 0.6 percent of sodium benzoate, 1.1 percent of edible essence, 0.2 percent of strontium chloride, 0.08 percent of dipotassium glycyrrhizinate, 0.02 percent of lysozyme, 0.005 percent of histidine, 0.002 percent of glycine and the balance of deionized water.
5. A method for preparing the bio-enzyme bacteriostatic and anti-allergic toothpaste according to any one of the claims 1 to 4, which comprises the following steps:
s1, adding xylitol, sucralose, sodium lauroyl sarcosinate, cocamidopropyl betaine, tetrasodium pyrophosphate, sodium benzoate, strontium chloride and dipotassium glycyrrhizinate into 3/4 water, heating and stirring to dissolve to obtain a solution a;
s2, weighing sorbitol, glycerol and polyethylene glycol-400, mixing, adding cellulose gum, and mixing to obtain glue b with consistency;
s3, weighing lysozyme, histidine and glycine, adding the lysozyme, the histidine and the glycine into 1/4 water, and stirring and dissolving to obtain a solution c;
and S4, adding the solution a into the glue b, stirring for 30min, adding the solution c, continuing stirring for 10min, standing for 12h, and filling.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112156046A (en) * | 2020-10-22 | 2021-01-01 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method, product and application of kyanite antibacterial and anti-inflammatory multifunctional toothpaste |
| CN112220707A (en) * | 2020-11-10 | 2021-01-15 | 江苏雪豹日化有限公司 | Tooth sensitivity resisting biological lysozyme toothpaste composition |
| CN113576942A (en) * | 2021-09-16 | 2021-11-02 | 梅州市和谐生物科技有限公司 | Anti-sugar toothpaste and preparation method thereof |
| CN114557932A (en) * | 2022-03-03 | 2022-05-31 | 李时珍医药集团有限公司 | Toothpaste containing folium artemisiae argyi and rosemary leaf extracts and preparation method thereof |
| CN115245468A (en) * | 2022-08-25 | 2022-10-28 | 杭州齿研生物科技有限公司 | Toothpaste capable of removing halitosis caused by periodontal disease |
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| CN108096049A (en) * | 2018-01-18 | 2018-06-01 | 胡茵 | Toothpaste containing amino acid surfactant and cationic bacteriostatic agent and preparation method thereof |
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| CN108785119A (en) * | 2018-08-16 | 2018-11-13 | 江苏雪豹日化有限公司 | A kind of amino acid bio complex enzyme toothpaste |
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|---|---|---|---|---|
| CN108096049A (en) * | 2018-01-18 | 2018-06-01 | 胡茵 | Toothpaste containing amino acid surfactant and cationic bacteriostatic agent and preparation method thereof |
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