CN113576938B - Oral care composition and application thereof - Google Patents
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention provides an oral care composition and application thereof, wherein the oral care composition comprises dipotassium glycyrrhizinate, fibronectin and lactoferrin. The oral care composition provided by the invention can effectively refresh breath and effectively relieve the problems of oral ulcer and gum sensitivity.
Description
Technical Field
The invention belongs to the field of oral care, and particularly relates to an oral care composition and application thereof, in particular to an oral care composition with a good care effect and application thereof.
Background
In recent years, as the living standard of people is improved, the oral care is also gradually paid attention to the public, and the growing trend of the oral care products is more and more obvious. Oral spray products are enjoyed by more and more people due to the use limitations of toothpaste products and the portability of oral spray products themselves. Most of the commercial oral spray products are only used for refreshing breath, and most of the products contain alcohol preparations, so that the products can stimulate oral mucosa to a certain extent and are not acceptable to some consumers. The needs of most consumers may be to solve the breath problem and to simultaneously alleviate or help to treat other problems occurring in the oral cavity, such as a series of problems including canker sores and periodontal diseases.
CN110859779A discloses an oral care product containing a plant fiber abrasive and a preparation method thereof, wherein the oral care product comprises an abrasive, a thickener and a humectant, the abrasive is plant fiber particles, the thickener comprises xanthan gum, and the humectant comprises polyethylene glycol 1500. The oral care product adopts plant fiber particles to replace the traditional abrasive, and has the characteristics of strong cleaning capability, small damage to teeth, fine and uniform paste and the like.
CN110755298A discloses a lyophilized oral care composition and its application, the raw materials include conventional ingredients and a matrix support agent; the skeleton supporting agent comprises a skeleton supporting agent A component and a skeleton supporting agent B component; the component A of the skeleton supporting agent is a mixture consisting of one or more than one of sodium carboxymethylcellulose, hydroxyethyl cellulose, carrageenan, Arabic gum, xanthan gum and sodium polyacrylate; the component B of the skeleton supporting agent is a mixture consisting of one or more than one of soluble starch, chitosan, wood fiber, mannitol and dextrin. The freeze-dried oral care product prepared from the composition of the scheme has the characteristic of stable tissue form, can be quickly dissolved when meeting water, and has no sticky feeling.
As consumer demands for oral care are increasing. Therefore, how to provide an oral care product capable of alleviating other oral problems becomes a problem to be solved urgently.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an oral care composition and application thereof, in particular to an oral care composition with good care effect and application thereof. The oral care composition provided by the invention can effectively refresh breath and effectively relieve the problems of oral ulcer and gum sensitivity.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides an oral care composition comprising dipotassium glycyrrhizinate, fibronectin and lactoferrin.
The oral care composition can effectively relieve and improve a series of problems of oral ulcer, sensitive gum, periodontal disease and the like by adopting the compounding of the dipotassium glycyrrhizinate, the fibronectin and the lactoferrin and the synergistic effect, and can effectively refresh breath by adopting the freshener.
Preferably, the oral care composition comprises 0.05 to 0.5 part of dipotassium glycyrrhizinate, 0.1 to 1 part of fibronectin and 0.5 to 1.5 parts of lactoferrin by weight.
The amount of dipotassium glycyrrhizinate may be 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc., the amount of fibronectin may be 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, etc., the amount of lactoferrin may be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, etc., but not limited thereto, and any other values not recited in the above-mentioned range are also applicable.
Preferably, the oral care composition comprises 0.2 to 0.4 part of dipotassium glycyrrhizinate, 0.3 to 0.7 part of fibronectin and 0.8 to 1.2 parts of lactoferrin in parts by weight.
The oral care composition with the specific proportion further relieves and improves a series of problems of oral ulcer, gum sensitivity, periodontal disease and the like.
In a second aspect, the present invention provides the use of an oral care composition as described above in the manufacture of an oral care product, wherein the oral care product comprises any one of an oral spray product, a mouthwash or a toothpaste.
The oral spray product can improve the contact area between the product and the oral cavity to a higher extent, is convenient for releasing and acting the effective substances, and has small single-time ingestion of the spray, thereby not giving people a sense of discomfort.
In a third aspect, the present invention provides an oral care product comprising, in parts by weight, 10.6 to 36.5 parts of a sugar alcohol, 0.65 to 3 parts of an oral care composition as described above, 0.01 to 0.3 part of a cooling agent, and 2 to 10 parts of a stabilizer.
The sugar alcohol may be present in an amount of 10.6 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 36.5 parts, etc., the oral care composition may be present in an amount of 0.65 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, or 3 parts, the refreshing agent may be present in an amount of 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, or 0.3 parts, the stabilizer may be present in an amount of 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts, etc., but the above-mentioned ranges are not limited thereto, and other values not listed in the above-mentioned ranges are also applicable.
Preferably, the oral care product comprises 17.5 to 30 parts of sugar alcohol, 1.3 to 2.3 parts of the oral care composition, 0.1 to 0.2 part of cooling agent and 4 to 8 parts of stabilizing agent by weight.
Preferably, the sugar alcohol comprises 0.5-5 parts of erythritol, 0.1-1.5 parts of xylitol and 10-30 parts of sorbitol in parts by weight.
The erythritol may be present in an amount of 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, or 5 parts, xylitol may be present in an amount of 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, or 1.5 parts, and sorbitol may be present in an amount of 10 parts, 15 parts, 20 parts, 25 parts, or 30 parts, but is not limited to the above-mentioned values, and other values not listed in the above-mentioned numerical range are also applicable.
Preferably, the sugar alcohol comprises 2-4 parts of erythritol, 0.5-1 part of xylitol and 15-25 parts of sorbitol in parts by weight.
Preferably, the cooling agent comprises any one of menthol and/or menthol lactate or a combination of at least two thereof.
Preferably, the stabilizer comprises any one of propylene glycol, glycerol or absolute ethyl alcohol or a combination of at least two of the foregoing.
Wherein the stabilizer may be a combination of propylene glycol and glycerin. Combinations of glycerin and absolute ethyl alcohol, or combinations of absolute ethyl alcohol and propylene glycol, and the like, but are not limited to the combinations listed above, and other combinations not listed within the above combination range are also applicable.
Preferably, the oral care product further comprises 0.05 to 0.3 parts by weight of a preservative, such as 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, or 0.3 parts, etc., but not limited to the above-listed values, and other values not listed within the above-mentioned range of values are equally applicable.
Preferably, the preservative comprises sodium benzoate and/or potassium sorbate.
Preferably, the oral care product further comprises 0.001-0.01 parts by weight of a sweetener, such as 0.001 parts, 0.002 parts, 0.003 parts, 0.004 parts, 0.005 parts, 0.006 parts, 0.007 parts, 0.008 parts, 0.009 parts, or 0.01 parts, and the like, but is not limited to the above-listed values, and other values not listed within the above-mentioned range of values are equally applicable.
Preferably, the sweetener includes any one or a combination of at least two of sucralose, xylitol, sorbitol, or dipotassium glycyrrhizinate, such as a combination of sucralose and xylitol, a combination of xylitol and sorbitol, or a combination of sucralose and sorbitol, but is not limited to the above-listed combinations, and other combinations not listed within the above-listed combinations are also applicable.
In a fourth aspect, the present invention also provides a process for the preparation of an oral care product as described above, comprising the steps of:
mixing sugar alcohol, the oral care composition as described above and water, and then mixing with the mixed solution of the cooling agent and the stabilizing agent to obtain the oral care product.
Preferably, mixing the sugar alcohol, oral care composition as described above, and water further comprises mixing with a preservative, sweetener.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides an oral care composition, which can effectively relieve and improve a series of problems such as dental ulcer, gingival sensitivity, periodontal disease and the like by adopting the compounding and synergistic effect of dipotassium glycyrrhizinate, fibronectin and lactoferrin, and can effectively refresh breath by adopting a freshener.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
Preparation example 1
The preparation example provides an oral care composition, which comprises the following components in parts by weight:
0.3 part of dipotassium glycyrrhizinate, 0.5 part of fibronectin and 1 part of lactoferrin.
The preparation method comprises the following steps: mixing dipotassium glycyrrhizinate, fibronectin and lactoferrin to obtain the oral care composition.
Preparation example 2
The preparation example provides an oral care composition, which comprises the following components in parts by weight:
0.4 part of dipotassium glycyrrhizinate, 0.3 part of fibronectin and 1.2 parts of lactoferrin.
The preparation method was the same as in preparation example 1.
Preparation example 3
The preparation example provides an oral care composition, which comprises the following components in parts by weight:
0.2 part of dipotassium glycyrrhizinate, 0.7 part of fibronectin and 0.8 part of lactoferrin.
The preparation method was the same as in preparation example 1.
Preparation example 4
The preparation example provides an oral care composition, which comprises the following components in parts by weight:
0.5 part of dipotassium glycyrrhizinate, 0.1 part of fibronectin and 1.5 parts of lactoferrin.
The preparation method was the same as in preparation example 1.
Preparation example 5
The preparation example provides an oral care composition, which comprises the following components in parts by weight:
dipotassium glycyrrhizinate 0.05 part, fibronectin 1 part and lactoferrin 0.5 part.
The preparation method was the same as in preparation example 1.
Comparative preparation example 1
This comparative preparation provides an oral care composition, the composition and proportions of which are identical to those of preparation 1, except that dipotassium glycyrrhizinate is not included, and a reduced proportion is proportionally allocated to fibronectin and lactoferrin.
The preparation method is referred to preparation example 1.
Comparative preparation example 2
This comparative preparation provides an oral care composition, the composition and proportions of which are identical to those of preparation example 1, except that fibronectin is not included, and a reduced proportion is apportioned to dipotassium glycyrrhizinate and lactoferrin.
The preparation method is referred to preparation example 1.
Comparative preparation example 3
This comparative preparation provides an oral care composition, the composition and proportions of which are identical to those of preparation 1, except that lactoferrin is not included, and a reduced proportion is apportioned to fibronectin and dipotassium glycyrrhizinate.
The preparation method is referred to preparation example 1.
Comparative preparation example 4
This comparative preparation provides an oral care composition, the composition and proportions of which are identical to those of preparation example 1, except that dipotassium glycyrrhizinate and lactoferrin are not included, and a reduced proportion of fibronectin is allocated.
The preparation method is referred to preparation example 1.
Comparative preparation example 5
This comparative preparation provides an oral care composition, the composition and proportions of which are identical to those of preparation 1, except that fibronectin and lactoferrin are not included, and that a reduced proportion is allocated to dipotassium glycyrrhizinate.
The preparation method is referred to preparation example 1.
Comparative preparation example 6
This comparative preparation provides an oral care composition, the composition and proportions of which are identical to those of preparation 1, except that fibronectin and dipotassium glycyrrhizinate are not included, and a reduced proportion of lactoferrin is allocated.
The preparation method is referred to preparation example 1.
Example 1
The embodiment provides an oral care product, which comprises the following components in percentage by mass:
erythritol 3%, xylitol 0.8%, sorbitol 20%, oral care composition 1.8% provided in preparation example 1, sodium benzoate 0.15%, sucralose 0.005%, menthol 0.15%, propylene glycol 6%, and the balance water.
The preparation method comprises the following steps:
dissolving erythritol, xylitol, sorbitol, sodium benzoate, sucralose and the oral care composition provided in preparation example 1 in deionized water, adding a solution prepared by mixing menthol and propylene glycol in advance, and stirring to obtain the oral care product.
Example 2
The embodiment provides an oral care product, which comprises the following components in percentage by mass:
erythritol 2%, xylitol 0.5%, sorbitol 15%, the oral care composition provided in preparation example 2 1.9%, potassium sorbate 0.05%, xylitol 0.01%, menthol 0.1%, glycerin 8%, and the balance water.
The preparation process was identical to example 1.
Example 3
The embodiment provides an oral care product, which comprises the following components in percentage by mass:
erythritol 4%, xylitol 1%, sorbitol 25%, the oral care composition provided in preparation example 3 1.8%, sorbitol 0.001%, menthol lactate 0.2%, anhydrous ethanol 4%, and the balance water.
The preparation method is identical to example 1.
Example 4
The embodiment provides an oral care product, which comprises the following components in percentage by mass:
erythritol 0.5%, xylitol 0.1%, sorbitol 10%, oral care composition 2.1% provided in preparation example 4, sodium benzoate 0.05%, sucralose 0.01%, menthol 0.01%, propylene glycol 10%, and the balance of water.
The preparation process was identical to example 1.
Example 5
The embodiment provides an oral care product, which comprises the following components in percentage by mass:
erythritol 5%, xylitol 1.5%, sorbitol 30%, oral care composition 1.55% provided in preparation example 5, sodium benzoate 0.3%, sucralose 0.001%, menthol 0.3%, propylene glycol 2%, and the balance water.
The preparation process was identical to example 1.
Comparative examples 1 to 6
Comparative examples 1-6 each provide an oral care product having a composition in accordance with example 1 except that the oral care composition provided in preparation example 1 was replaced with an equal amount of the oral care composition provided in comparative preparation examples 1-6, respectively.
The preparation method refers to example 1.
And (3) effect testing:
110 volunteers suffering from oral ulcer and gingival inflammation were selected, randomly and averagely divided into 11 groups, their oral conditions were scored, the oral care products provided in examples 1 to 5 and comparative examples 1 to 6 were placed in prepared spray bottles, and then each group was scored again after two weeks using the oral care products provided in examples 1 to 5 and comparative examples 1 to 6, respectively, 3 times a day, 2mL each time, two weeks, and the score differences and the average values thereof were calculated, and the scoring criteria (table 1) and the test results (table 2) were as follows:
TABLE 1
| Score value | Description of the symptoms |
| 1 point is | Painless |
| 2 is divided into | The feeling of numbness is hidden when drinking or eating, and the feeling is not felt when not drinking or eating |
| 3 points of | The pain is not relieved when drinking or eating, and the pain is not relieved when not drinking or eating |
| 4 is divided into | Pain when drinking or eating, and no pain when not drinking or eating |
| 5 points of | Intermittent pain during eating without drinking water |
TABLE 2
| Group of | Difference of mean value | Group of | Difference of mean value | Group of | Difference of mean value |
| Example 1 | 2.5 | Example 5 | 1.0 | Comparative example 4 | 0.4 |
| Example 2 | 2.1 | Comparative example 1 | 0.9 | Comparative example 5 | 0.1 |
| Example 3 | 1.8 | Comparative example 2 | 0.5 | Comparative example 6 | 0.6 |
| Example 4 | 1.1 | Comparative example 3 | 0.3 |
In addition, Gingival Index (GI) was tested according to evaluation method "WS/T326.3-2010 toothpaste efficacy evaluation part 3 inhibits plaque and/or reduces gingival inflammation".
Gingival Index (GI): each periodontal paragum was examined by blunt probe, examination of the mesio-labial-buccal papilla, the median labial-buccal margin, the distal labial-buccal papilla and the lingual-gingival margin. Mean values for the tooth surface were recorded per tooth, mean values for the examined teeth were recorded per person, the scoring criteria (table 3) and the test results (table 4) were as follows:
TABLE 3
TABLE 4
| Group of | Difference of average value | Group of | Difference of average value | Group of | Difference of average value |
| Example 1 | 1.0 | Example 5 | 0.4 | Comparative example 4 | 0.1 |
| Example 2 | 0.8 | Comparative example 1 | 0.3 | Comparative example 5 | 0 |
| Example 3 | 0.6 | Comparative example 2 | 0.2 | Comparative example 6 | 0.2 |
| Example 4 | 0.5 | Comparative example 3 | 0.1 |
The results show that the oral care composition provided by the invention can effectively relieve and improve a series of problems such as oral ulcer, sensitive gum and periodontal disease; compared with the embodiment 1 and the comparative examples 1 to 6, the invention can find that a series of problems of oral ulcer, gingival sensitivity, periodontal disease and the like are obviously relieved and improved by adopting the compounding of the dipotassium glycyrrhizinate, the fibronectin and the lactoferrin and the synergistic effect.
The applicants state that the present invention is illustrative of the oral care compositions and uses thereof by way of the above examples, but the invention is not limited to the above examples, i.e., it is not meant that the invention must be practiced in reliance thereon. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (14)
1. An oral care composition, which is characterized by comprising 0.05 to 0.5 part of dipotassium glycyrrhizinate, 0.1 to 1 part of fibronectin and 0.5 to 1.5 parts of lactoferrin by weight.
2. The oral care composition of claim 1, wherein the oral care composition comprises, in parts by weight, dipotassium glycyrrhizinate 0.2-0.4 parts, fibronectin 0.3-0.7 parts, and lactoferrin 0.8-1.2 parts.
3. Use of an oral care composition according to claim 1 or 2 in the manufacture of an oral care product comprising any of an oral spray product, a mouthwash or a toothpaste.
4. An oral care product comprising, in parts by weight, 10.6 to 36.5 parts of a sugar alcohol, 0.65 to 3 parts of an oral care composition according to claim 1 or 2, 0.01 to 0.3 part of a cooling agent, and 2 to 10 parts of a stabilizer.
5. The oral care product of claim 4, comprising, in parts by weight, 17.5 to 30 parts of a sugar alcohol, 1.3 to 2.3 parts of the oral care composition of claim 1 or 2, 0.1 to 0.2 part of a cooling agent, and 4 to 8 parts of a stabilizer.
6. The oral care product according to claim 4, wherein the sugar alcohol comprises, in parts by weight, erythritol 0.5-5 parts, xylitol 0.1-1.5 parts, and sorbitol 10-30 parts.
7. The oral care product of claim 6, wherein the sugar alcohol comprises, in parts by weight, erythritol 2-4 parts, xylitol 0.5-1 parts, and sorbitol 15-25 parts.
8. The oral care product of claim 4, wherein the cooling agent comprises menthol and/or menthyl lactate.
9. The oral care product of claim 4, wherein the stabilizing agent comprises any one of propylene glycol, glycerin, or absolute ethanol, or a combination of at least two thereof.
10. The oral care product of claim 4, further comprising a preservative in an amount of 0.05 to 0.3 parts by weight.
11. The oral care product of claim 10, wherein the preservative comprises sodium benzoate and/or potassium sorbate.
12. The oral care product of claim 4, further comprising 0.001 to 0.01 parts by weight of a sweetener.
13. The oral care product of claim 12, wherein the sweetener comprises any one of sucralose, xylitol, sorbitol, or dipotassium glycyrrhizinate, or a combination of at least two thereof.
14. A method of making an oral care product according to any one of claims 4 to 9, comprising the steps of:
mixing a sugar alcohol, the oral care composition of claim 1 or 2, and water, and then mixing with a mixed solution of a cooling agent and a stabilizer to obtain the oral care product.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796428A (en) * | 2016-04-20 | 2016-07-27 | 苏州蔻美新材料有限公司 | Medical tooth sanitary cleanser and preparation method thereof |
| CN110755291A (en) * | 2018-07-28 | 2020-02-07 | 吴红军 | Anti-inflammatory and bactericidal mouthwash |
| CN111568826A (en) * | 2020-05-19 | 2020-08-25 | 四川涑爽医疗用品有限公司 | Oral care composition capable of resisting inflammation, relieving pain and preventing ulcer, oral care toothpaste and preparation method of oral care toothpaste |
| CN111643384A (en) * | 2020-07-27 | 2020-09-11 | 浙江爱尚日用品有限公司 | Biological enzyme oral cleaning and nursing toothpaste |
| WO2021074158A1 (en) * | 2019-10-14 | 2021-04-22 | Lacer, S.A. | Oral care composition |
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| CN110755291A (en) * | 2018-07-28 | 2020-02-07 | 吴红军 | Anti-inflammatory and bactericidal mouthwash |
| WO2021074158A1 (en) * | 2019-10-14 | 2021-04-22 | Lacer, S.A. | Oral care composition |
| CN111568826A (en) * | 2020-05-19 | 2020-08-25 | 四川涑爽医疗用品有限公司 | Oral care composition capable of resisting inflammation, relieving pain and preventing ulcer, oral care toothpaste and preparation method of oral care toothpaste |
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