CN115721594A - Toothpaste containing ginkgo extract and preparation method thereof - Google Patents
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Abstract
The invention discloses a toothpaste containing ginkgo biloba extract, comprising a preparation method thereof; the invention belongs to the technical field of toothpaste, and particularly relates to toothpaste containing ginkgo biloba extract and a preparation method thereof; the toothpaste comprises the following components in parts by weight: 50-100 parts of ginkgo leaf extract, 10-20 parts of traditional Chinese medicine compound auxiliary agent, 10-30 parts of abrasive agent, 1-10 parts of foaming agent, 10-20 parts of humectant, 1-10 parts of thickening agent, 0.1-5 parts of essence, 0.1-5 parts of preservative, 1-5 parts of pH regulator and the balance of deionized water. The invention provides a traditional Chinese medicine compound auxiliary agent and a ginkgo leaf extract to generate a synergistic effect, so that flavonoid glycosides, ginkgolic acids, bilobalides, polyisoprene and polysaccharide in the ginkgo leaves can more efficiently play a role; the invention adopts the adsorption resin separation method to extract the ginkgo leaves, which can greatly improve the flavone content and obtain the high-purity extract; the invention provides toothpaste which has the advantages of high efficiency, anti-inflammation, blood viscosity reduction, microcirculation improvement, anti-tumor, whitening and cleaning.
Description
Technical Field
The invention belongs to the technical field of toothpaste, and particularly relates to toothpaste containing ginkgo biloba extract and a preparation method thereof.
Background
The ginkgo biloba is a plant in the ginkgo family and the ginkgo genus, is a fast-growing and precious tree species, has certain antibacterial and anti-bacterial adhesion effects in the oral cavity, has the effects of enhancing immunity and promoting tumor cell apoptosis, has certain curative effect on oral cancer, and can inhibit the carcinogenic effect of substances such as nitrosamine and the like.
Toothpaste is a common oral care product for people, and has the basic functions of refreshing breath, keeping oral health and protecting teeth; in addition, the functional toothpaste with specific functions also has the functions of inhibiting the growth of dental plaque, reducing the growth of dental plaque, preventing dental caries, slowing down the further deterioration of the generated dental caries, resisting dentinal hypersensitivity, improving tooth discoloration, brightening and whitening teeth and protecting enamel; the toothpaste is a paste material, and comprises main ingredients of abrasive, humectant, thickener, foaming agent, aromatic, water and other additives; with the continuous improvement and development of science and technology and the continuous improvement and perfection of technology and equipment, various toothpastes come out one after another, the product quality and grade are also continuously improved, but certain problems still exist, for example, patent number CN103083212A proposes a salvia miltiorrhiza toothpaste, which is mainly prepared from the following raw materials: 8-12 parts of salvia miltiorrhiza extract, 2-4 parts of codonopsis pilosula extract, 2-4 parts of ginkgo leaf extract, 2-4 parts of lotus leaf extract, 2-4 parts of polygonum multiflorum extract, 2-4 parts of curcuma aromatica extract and 68-82 parts of toothpaste matrix, and has a certain effect on preventing and treating cardiovascular diseases, but the extracts are only decolorized after being concentrated, so that the efficiency is low, the impurity content is high, the loss of effective components is serious, and the invention has no research on the aspects of whitening, anti-inflammation and the like; therefore, the invention provides the toothpaste containing the ginkgo biloba extract, which can effectively brush away stains on teeth, has remarkable effects of diminishing inflammation, stopping bleeding and repairing canker sores, has good prevention and treatment effects on oral and dental diseases such as periodontitis, gingivitis, caries, oral odor and the like, and also provides an efficient preparation method.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides toothpaste containing ginkgo biloba extract and a preparation method thereof, the invention provides that the ginkgo biloba extract is used as an effective component, a traditional Chinese medicine compound is used as an auxiliary agent, and the ginkgo biloba extract and the traditional Chinese medicine compound generate synergistic action, so that flavonoid glycosides, ginkgolic acids, bilobalides, polyisoprene and polysaccharide in the ginkgo biloba can more efficiently play a role; meanwhile, the ginkgo leaves are extracted by an adsorption resin separation method, so that the flavone content can be greatly improved, and a high-purity extract is obtained; in summary, the invention provides a toothpaste which has the advantages of high efficiency, anti-inflammation, blood viscosity reduction, microcirculation improvement, anti-tumor, whitening and cleaning.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: the invention provides toothpaste containing ginkgo biloba extract and a preparation method thereof, wherein the toothpaste comprises the following components in parts by weight: 50-100 parts of ginkgo leaf extract, 10-20 parts of traditional Chinese medicine compound auxiliary agent, 10-30 parts of abrasive agent, 1-10 parts of foaming agent, 10-20 parts of humectant, 1-10 parts of thickening agent, 0.1-5 parts of essence, 0.1-5 parts of preservative, 1-5 parts of pH regulator and the balance of deionized water.
Preferably, the toothpaste comprises the following components in parts by weight: 60-80 parts of ginkgo leaf extract, 15-20 parts of traditional Chinese medicine compound auxiliary agent, 15-20 parts of abrasive agent, 2-8 parts of foaming agent, 10-15 parts of humectant, 3-6 parts of thickening agent, 0.1-2 parts of essence, 0.1-2 parts of preservative, 2-5 parts of pH regulator and the balance of deionized water.
Further, the traditional Chinese medicine compound auxiliary comprises the following components in parts by weight: 1-10 parts of clausena lansium kernel extract, 2-8 parts of Chinese alangium extract, 2-9 parts of equisetum extract, 1-8 parts of tatarian stonecrop herb extract and 3-15 parts of Chinese walnut leaf extract.
Preferably, the traditional Chinese medicine compound auxiliary comprises the following components in parts by weight: 2-8 parts of clausena lansium kernel extract, 3-5 parts of Chinese alangium extract, 3-8 parts of equisetum extract, 2-6 parts of tatarian stonecrop herb extract and 4-10 parts of Chinese walnut leaf extract.
Further, the friction agent comprises one or more of friction type silicon dioxide, calcium hydrogen phosphate dihydrate or the combination of the two.
Further, the foaming agent comprises one or more of sodium lauryl sulfate, cocamidopropyl betaine or sodium lauroyl sarcosinate; the humectant comprises one or more of sorbitol, glycerol and propylene glycol; the thickening agent comprises one or more of sodium carboxymethyl cellulose and silicon dioxide; the essence comprises one or more of lemon oil, spearmint oil, orange oil, tangerine oil, wintergreen oil, clove oil and cinnamon oil; the preservative comprises one or more of triclosan, methyl paraben, ethyl paraben and sodium benzoate; the pH regulator is one or more of citric acid, sodium dihydrogen phosphate and disodium hydrogen phosphate.
The invention also provides a preparation method of the toothpaste containing the ginkgo biloba extract, which comprises the following steps:
(1) Crushing ginkgo leaves, and adding 10 times of 85% ethanol for soaking for 60 minutes; heating and refluxing the soaked mixture twice, wherein each time lasts for 2 hours, combining the alcohol extract, and filtering through a stainless steel mesh of 200 meshes to obtain a filtrate for later use;
(2) Separating the filtrate with adsorbent resin, removing acid, eluting, recovering to obtain refined solution, spray drying or concentrating under reduced pressure, and pulverizing into 180 mesh fine powder to obtain semen Ginkgo dry extract powder;
(3) Mixing the clausena lansium kernels, the alangium platanifolium, the dichondra repens leaves, the sarcandra and the schefflera arboricola leaves, and adding 10 times of 85% ethanol for soaking for 60 minutes; heating and refluxing the soaked mixture twice, each time for 2 hours, combining the alcohol extract, filtering through a stainless steel mesh of 200 meshes, and keeping the filtrate for later use; adding 10 times of water into the residues after alcohol extraction, decocting for 2 times, each time for 1 hr, mixing decoctions, filtering through 200 mesh stainless steel net, and concentrating the filtrate to obtain Chinese medicinal compound extract with relative density of 1.10;
(4) Adding a proper amount of deionized water into the ginkgo dry paste powder and the Chinese medicinal compound extract, then adding an abrasive, a foaming agent, a humectant, a thickening agent, essence and a preservative, adjusting the pH to 9.0 by using sodium dihydrogen phosphate and disodium hydrogen phosphate, and stirring for 10-25 minutes in vacuum to obtain the toothpaste body.
The invention with the structure has the following beneficial effects:
the invention provides a synergistic effect of the traditional Chinese medicine compound auxiliary agent and the ginkgo leaf extract, so that flavonoid glycosides, ginkgolic acids, bilobalides, polyisoprene and polysaccharide in the ginkgo leaf can more efficiently play a role; the ginkgo leaf is extracted by an adsorption resin separation method, so that the flavone content can be greatly improved, and a high-purity extract is obtained; the invention provides toothpaste which has the advantages of high efficiency, anti-inflammation, blood viscosity reduction, microcirculation improvement, anti-tumor, whitening and cleaning.
The invention takes the ginkgo leaf extract and the traditional Chinese medicine compound auxiliary agent as main active ingredients to realize the effects of anti-inflammation, whitening and the like of the toothpaste.
The ginkgo leaves have high medicinal value, mild nature, bitter, sweet and astringent taste, and the effects of benefiting heart, astringing spleen, eliminating dampness, stopping diarrhea and the like, and the active ingredients of the ginkgo leaves have good prevention and treatment effects on daily care of the oral cavity; the Clausena lansium stone is seed of Clausena lansium (Clausena lansium) of Rutaceae of dicotyledon, has pungent and slightly bitter taste, warm nature, and no toxicity, and can remove food retention and swelling; the Alangium platanifolium leaf is leaf of Alangium platanifolium of Alangicaceae, and has pungent, bitter and mild properties, and has effects of removing toxic substance, relieving swelling, removing blood stasis and relieving pain; the whole herb of dichondra repens is used for medicine, and has the functions of clearing heat, promoting urination, dispelling wind, relieving pain, stopping bleeding, promoting granulation, diminishing inflammation, detoxifying and killing insects; can be used for treating acute and chronic hepatitis, renal tonsillitis, stomatitis, etc., and herba Clerodendri Bungei has soft leaf, high edibility, bitter and cold property, and has effects of dispelling pathogenic wind and cold, and relieving swelling and cough; the Chinese walnut leaf can promote qi circulation to relieve pain, and promote blood circulation to reduce swelling.
Drawings
FIG. 1 shows the antibacterial effect of toothpaste containing ginkgo extract on oral cavity;
FIG. 2 is a graph showing the effect of a toothpaste containing ginkgo biloba extract on colony count according to the present invention;
fig. 3 is a result of measuring the stain removal value of a toothpaste containing ginkgo biloba extract according to the present invention.
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments; all other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described herein can be used in the practice of the present invention. The preferred embodiments and materials described herein are exemplary only, and are not intended to limit the scope of the present application.
The experimental methods in the following examples are all conventional methods unless otherwise specified; the test materials and test strains used in the following examples were all commercially available unless otherwise specified.
Example 1
Toothpaste containing ginkgo extract and preparation method thereof
The toothpaste comprises the following components in parts by weight: 60 parts of ginkgo leaf extract, 15 parts of traditional Chinese medicine compound auxiliary agent, 15 parts of abrasive, 2 parts of foaming agent, 10 parts of humectant, 3 parts of thickening agent, 0.1 part of essence, 0.1 part of preservative, 2 parts of pH regulator and the balance of deionized water.
The traditional Chinese medicine compound auxiliary comprises the following components in parts by weight: 4 parts of clausena lansium kernel extract, 4 parts of Chinese alangium extract, 3 parts of equisetum extract, 5 parts of tatarian stonecrop herb extract and 8 parts of Chinese quince leaf extract.
Wherein the abrasive is abrasive silica; the foaming agent is sodium dodecyl sulfate and cocamidopropyl betaine; the humectant is glycerin; the thickening agent is sodium carboxymethyl cellulose; the essence is clove oil; the preservative is sodium benzoate; the pH regulator is citric acid and sodium dihydrogen phosphate.
The invention also provides a preparation method of the toothpaste containing the ginkgo biloba extract, which comprises the following steps:
(1) Crushing ginkgo leaves, and adding 10 times of 85% ethanol for soaking for 60 minutes; heating and refluxing the soaked mixture twice, wherein each time lasts for 2 hours, combining the alcohol extract, and filtering through a stainless steel mesh of 200 meshes to obtain a filtrate for later use;
(2) Separating the filtrate with adsorbent resin, removing acid, eluting, recovering to obtain refined solution, spray drying or concentrating under reduced pressure, pulverizing into 180 mesh fine powder, and making into semen Ginkgo dry extract powder;
(3) Mixing the clausena lansium kernels, the alangium platanifolium, the dichondra repens leaves, the sarcandra and the schefflera arboricola leaves, and adding 10 times of 85% ethanol for soaking for 60 minutes; heating and refluxing the soaked mixture twice, wherein each time lasts for 2 hours, combining the alcohol extract, and filtering through a stainless steel mesh of 200 meshes to obtain a filtrate for later use; adding 10 times of water into the residues after alcohol extraction, decocting for 2 times, each time for 1 hr, mixing decoctions, filtering through 200 mesh stainless steel net, and concentrating the filtrate to Chinese medicinal compound extract with relative density of 1.10;
(4) Adding a proper amount of deionized water into the ginkgo dry paste powder and the Chinese medicinal compound extract, then adding a rubbing agent, a foaming agent, a humectant, a thickening agent, essence and a preservative, adjusting the pH to 9.0 by using sodium dihydrogen phosphate and disodium hydrogen phosphate, and stirring for 10-25 minutes in vacuum to obtain the toothpaste body.
Example 2
Toothpaste containing ginkgo extract and preparation method thereof
The toothpaste comprises the following components in parts by weight: 70 parts of ginkgo leaf extract, 18 parts of traditional Chinese medicine compound auxiliary agent, 15 parts of abrasive, 4 parts of foaming agent, 10 parts of humectant, 3 parts of thickening agent, 0.1 part of essence, 0.1 part of preservative, 3 parts of pH regulator and the balance of deionized water.
The traditional Chinese medicine compound auxiliary comprises the following components in parts by weight: 4 parts of clausena lansium kernel extract, 4 parts of Chinese alangium extract, 3 parts of dichondra repens extract, 5 parts of sarcandra extracts and 8 parts of Chinese walnut leaf extracts.
Wherein the abrasive is abrasive silica; the foaming agent is sodium dodecyl sulfate and cocamidopropyl betaine; the humectant is glycerin; the thickening agent is sodium carboxymethyl cellulose; the essence is clove oil; the preservative is sodium benzoate; the pH regulator is citric acid and sodium dihydrogen phosphate.
In addition, the present invention also provides a toothpaste containing ginkgo biloba extract and a preparation method thereof, which is performed with reference to example 1.
Example 3
Toothpaste containing ginkgo extract and preparation method thereof
The toothpaste comprises the following components in parts by weight: 80 parts of ginkgo leaf extract, 20 parts of traditional Chinese medicine compound auxiliary agent, 16 parts of abrasive agent, 6 parts of foaming agent, 12 parts of humectant, 5 parts of thickening agent, 0.1 part of essence, 0.1 part of preservative, 3 parts of pH regulator and the balance of deionized water.
The traditional Chinese medicine compound auxiliary comprises the following components in parts by weight: 4 parts of clausena lansium kernel extract, 4 parts of Chinese alangium extract, 3 parts of equisetum extract, 5 parts of tatarian stonecrop herb extract and 8 parts of Chinese quince leaf extract.
Wherein the abrasive is abrasive silica; the foaming agent is sodium dodecyl sulfate and cocamidopropyl betaine; the humectant is glycerin; the thickening agent is sodium carboxymethyl cellulose; the essence is clove oil; the preservative is sodium benzoate; the pH regulator is citric acid and sodium dihydrogen phosphate.
In addition, the present invention also provides a toothpaste containing ginkgo biloba extract and a preparation method thereof, which are performed with reference to example 1.
Comparative example 1
The comparative example provides a toothpaste containing ginkgo biloba extract and a preparation method, which are different from the toothpaste of example 1 only in that all components do not contain traditional Chinese medicine compound auxiliary agents, and the rest components and the content of the components are the same as the toothpaste of example 1.
Experimental example 1
A toothpaste containing ginkgo extract with antibacterial effect on oral cavity
The oral sterilization tests were performed on the toothpastes of examples 1, 2, 3 and comparative example 1 for a total of 80 oral healthy patients, and randomly divided into 4 groups of 20, and the toothpastes of examples 1, 2, 3 and comparative example 1 were used to brush teeth once a day, five minutes each in the morning and evening, and the oral sterilization rates of the different groups of toothpastes were calculated on the seventh day.
Collecting saliva of different volunteers, diluting with sterile PBS, coating 0.2mL of the saliva on BHIA plates, performing anaerobic culture at 37 ℃ for 72h, respectively eluting the BHIA plates with 2mL of sterile PBS solution, and collecting eluate as oral bacteria solution for testing; respectively measuring 75mL of sterile PBS and 25g of sample (25 mL of PBS solution is used for a blank group, toothpaste with different formulas is used for an experimental group), sucking 9mL of slurry, and adding the slurry into a test tube for later use; diluting the eluate with sterile PBS to 1 × 106 CFU/mL; sucking 1.0mL of bacterial suspension, adding the bacterial suspension into 9mL of the prepared slurry, shaking and uniformly mixing, sucking the mixed solution after 2min for proper dilution, and counting bacteria after anaerobic culture for 72 h. Calculating the formula: sterilization rate = (average number of colonies in blank group-average number of colonies in experimental group)/average number of colonies in blank group × 100%.
As shown in figure 1, the toothpaste prepared in the invention has good sterilization effect, the sterilization rate of the toothpaste prepared in the embodiment 3 is 98.47%, the sterilization effects of the toothpaste prepared in the embodiments 2 and 1 are the second best, and the sterilization rate of the toothpaste prepared in the comparative example 1 is 16.67% lowest; as shown in fig. 2, at day 3, a is the colony count of the toothpaste of comparative example 1; b is the colony count of the toothpaste of example 1; c is the colony count of the toothpaste of example 2; d is the number of colonies of the toothpaste of example 3, the number of colonies being the smallest in example 3 and the largest in comparative example 1, with examples 1 and 2 being in an intermediate position.
Experimental example 2
A toothpaste containing ginkgo extract for treating oral ulcer
The toothpaste of examples 1, 2, 3 and comparative example 1 were subjected to oral clinical tests, and a total of 80 patients with recurrent oral ulceration accompanied by symptoms of swelling and aching of the gums and bleeding of the gums; 80 volunteers were randomly divided into 4 groups of 20, and brushed daily with the toothpastes of examples 1, 2, 3 and comparative example 1, once a day, five minutes each time, for 2 months.
The result analysis shows that as shown in table 1, the toothpaste prepared according to the formula in example 3 has a remarkable effect on patients with dental ulcer, the remarkable rate reaches 80%, the effective rate is 100%, and the bleeding gum and the swelling and aching gum of the patients are eliminated or slowed down to some extent; the toothpaste prepared according to the formula of the comparative example 1 has no obvious effect on patients suffering from oral ulcer, and the effective rate is only 5%.
TABLE 1 effect of a toothpaste containing ginkgo biloba extract on patients with oral ulcer
Experimental example 3
Cleanliness test of toothpaste containing ginkgo extract
Preparing a white porcelain plate subjected to concentrated tea multiple-time soaking and drying treatment, averagely dividing the white porcelain plate into 4 areas by a corrected whiteness instrument, respectively brushing the areas for 10 times by using the toothpaste of the examples 1, 2 and 3 and the toothpaste of the comparative example 1 in a rotating manner, and after the areas are washed by clear water, comparing the whiteness difference before and after the areas are compared, and calculating the decontamination value, wherein the decontamination value = whiteness after brushing-whiteness before brushing.
As a result of analysis, as shown in FIG. 3, the toothpaste of example 3 according to the present invention had a stain removal value of 61.58 at the highest, the toothpaste of example 2 had a stain removal value of 47.97, the toothpaste of example 1 had a stain removal value of 40.97, and the toothpaste of comparative example 1 had a stain removal value of 10.5 at the lowest.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The present invention and its embodiments have been described above, and the description is not intended to be limiting, and the drawings are only one embodiment of the present invention, and the actual structure is not limited thereto. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A toothpaste containing ginkgo biloba extract is characterized in that: the toothpaste comprises the following components in parts by weight: 50-100 parts of ginkgo leaf extract, 10-20 parts of traditional Chinese medicine compound auxiliary agent, 10-30 parts of abrasive agent, 1-10 parts of foaming agent, 10-20 parts of humectant, 1-10 parts of thickening agent, 0.1-5 parts of essence, 0.1-5 parts of preservative, 1-5 parts of pH regulator and the balance of deionized water.
2. The toothpaste comprising an extract of ginkgo biloba as claimed in claim 1, wherein: the toothpaste comprises the following components in parts by weight: 60-80 parts of ginkgo leaf extract, 15-20 parts of traditional Chinese medicine compound auxiliary agent, 15-20 parts of abrasive agent, 2-8 parts of foaming agent, 10-15 parts of humectant, 3-6 parts of thickening agent, 0.1-2 parts of essence, 0.1-2 parts of preservative, 2-5 parts of pH regulator and the balance of deionized water.
3. The toothpaste containing ginkgo biloba extract as claimed in claim 2, wherein: the traditional Chinese medicine compound auxiliary comprises the following components in parts by weight: 1-10 parts of clausena lansium kernel extract, 2-8 parts of Chinese alangium extract, 2-9 parts of equisetum extract, 1-8 parts of tatarian stonecrop herb extract and 3-15 parts of Chinese walnut leaf extract.
4. The toothpaste comprising an extract of ginkgo biloba as claimed in claim 3, wherein: the traditional Chinese medicine compound auxiliary comprises the following components in parts by weight: 2-8 parts of clausena lansium kernel extract, 3-5 parts of Chinese alangium extract, 3-8 parts of equisetum extract, 2-6 parts of tatarian stonecrop herb extract and 4-10 parts of Chinese walnut leaf extract.
5. The toothpaste containing ginkgo extract as claimed in claim 4, wherein: the friction agent comprises one or more of friction type silicon dioxide, calcium hydrophosphate dihydrate and the combination of more than one of the friction type silicon dioxide and the calcium hydrophosphate.
6. The toothpaste containing ginkgo extract as claimed in claim 5, wherein: the foaming agent comprises one or more of sodium lauryl sulfate, cocamidopropyl betaine or sodium lauroyl sarcosinate.
7. The toothpaste comprising an extract of ginkgo biloba according to claim 6, wherein: the humectant comprises one or more of sorbitol, glycerol and propylene glycol, and the thickener comprises one or more of sodium carboxymethylcellulose and silicon dioxide.
8. The toothpaste comprising an extract of ginkgo biloba according to claim 7, wherein: the essence comprises one or more of lemon oil, spearmint oil, orange oil, tangerine oil, wintergreen oil, clove oil and cinnamon oil.
9. The toothpaste comprising an extract of ginkgo biloba according to claim 8, wherein: the preservative comprises one or more of triclosan, methyl paraben, ethyl paraben and sodium benzoate; the pH regulator is one or more of citric acid, sodium dihydrogen phosphate and disodium hydrogen phosphate.
10. A method of preparing a toothpaste containing ginkgo biloba extract according to claim 9, wherein said method comprises the steps of: the method specifically comprises the following steps:
(1) Pulverizing folium Ginkgo, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice, each time for 2 hours, combining the alcohol extract, filtering through a stainless steel mesh of 200 meshes, and keeping the filtrate for later use;
(2) Separating the filtrate with adsorbent resin, removing acid, eluting, recovering to obtain refined solution, spray drying or concentrating under reduced pressure, pulverizing into 180 mesh fine powder, and making into semen Ginkgo dry extract powder;
(3) Mixing seed of Chinese wampee, leaves of Alangium platanifolium, leaf of Dictamnus mollis, herba Lysimachiae, and folium Schefflerae Arboricolae, adding 10 times of 85% ethanol, and soaking for 60 min; heating and refluxing the soaked mixture twice, each time for 2 hours, combining the alcohol extract, filtering through a stainless steel mesh of 200 meshes, and keeping the filtrate for later use; adding 10 times of water into the residues after alcohol extraction, decocting for 2 times, each time for 1 hr, mixing decoctions, filtering through 200 mesh stainless steel net, and concentrating the filtrate to obtain Chinese medicinal compound extract with relative density of 1.10;
(4) Adding a proper amount of deionized water into the ginkgo dry paste powder and the Chinese medicinal compound extract, then adding a rubbing agent, a foaming agent, a humectant, a thickening agent, essence and a preservative, adjusting the pH to 9.0 by using sodium dihydrogen phosphate and disodium hydrogen phosphate, and stirring for 10-25 minutes in vacuum to obtain the toothpaste body.
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Cited By (1)
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| CN117860626A (en) * | 2023-09-14 | 2024-04-12 | 广州中科佰氏健康产业有限公司 | Halitosis-resistant toothpaste containing natural medicinal composition and preparation method thereof |
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