CN109745263A - Subprostrate sophora pseudo-ginseng herbal mixture toothpaste and preparation method thereof - Google Patents
Subprostrate sophora pseudo-ginseng herbal mixture toothpaste and preparation method thereof Download PDFInfo
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- CN109745263A CN109745263A CN201910228448.1A CN201910228448A CN109745263A CN 109745263 A CN109745263 A CN 109745263A CN 201910228448 A CN201910228448 A CN 201910228448A CN 109745263 A CN109745263 A CN 109745263A
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- subprostrate sophora
- ginseng
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- 241000219784 Sophora Species 0.000 title claims abstract description 107
- 244000131316 Panax pseudoginseng Species 0.000 title claims abstract description 90
- 235000003181 Panax pseudoginseng Nutrition 0.000 title claims abstract description 90
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 73
- 239000000606 toothpaste Substances 0.000 title claims abstract description 73
- 239000000203 mixture Substances 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 47
- 229930013930 alkaloid Natural products 0.000 claims abstract description 27
- 150000003797 alkaloid derivatives Chemical class 0.000 claims abstract description 27
- 229930182490 saponin Natural products 0.000 claims abstract description 20
- 150000007949 saponins Chemical class 0.000 claims abstract description 20
- 235000017709 saponins Nutrition 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 14
- 238000000227 grinding Methods 0.000 claims abstract description 9
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- 239000011159 matrix material Substances 0.000 claims abstract description 5
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 20
- 235000019441 ethanol Nutrition 0.000 claims description 19
- 239000000706 filtrate Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
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- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 9
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- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 9
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 9
- 229960003415 propylparaben Drugs 0.000 claims description 9
- 229960004029 silicic acid Drugs 0.000 claims description 9
- RRLOOYQHUHGIRJ-UHFFFAOYSA-M sodium;ethyl sulfate Chemical compound [Na+].CCOS([O-])(=O)=O RRLOOYQHUHGIRJ-UHFFFAOYSA-M 0.000 claims description 9
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims description 9
- 229960000401 tranexamic acid Drugs 0.000 claims description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 8
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- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 8
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- 229920000573 polyethylene Polymers 0.000 claims description 8
- 229940085605 saccharin sodium Drugs 0.000 claims description 8
- ZOMATQMEHRJKLO-UHFFFAOYSA-N 1h-imidazol-2-ylmethanol Chemical compound OCC1=NC=CN1 ZOMATQMEHRJKLO-UHFFFAOYSA-N 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 5
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- 230000004054 inflammatory process Effects 0.000 description 3
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 2
- RRTJBIJAUFOAGW-UHFFFAOYSA-N 2-methyl-1h-imidazol-5-ol Chemical class CC1=NC=C(O)N1 RRTJBIJAUFOAGW-UHFFFAOYSA-N 0.000 description 2
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- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
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- IECCBIAUDOFPQL-UHFFFAOYSA-N 1,3-oxazolidin-2-ylurea Chemical compound O1C(NCC1)NC(=O)N IECCBIAUDOFPQL-UHFFFAOYSA-N 0.000 description 1
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- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 1
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- 235000004357 Mentha x piperita Nutrition 0.000 description 1
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- 241001529246 Platymiscium Species 0.000 description 1
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 240000000851 Vaccinium corymbosum Species 0.000 description 1
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- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention discloses subprostrate sophora pseudo-ginseng herbal mixture toothpaste, including subprostrate sophora pseudo-ginseng composition, the weight percent that subprostrate sophora pseudo-ginseng composition accounts for subprostrate sophora pseudo-ginseng herbal mixture toothpaste is 0.05-2%, and subprostrate sophora pseudo-ginseng composition is pseudo-ginseng total saponins and subprostrate sophora alkaloid extract;And the preparation method of subprostrate sophora pseudo-ginseng herbal mixture toothpaste, comprising: by subprostrate sophora pseudo-ginseng composition be added toothpaste matrix in, after agitation grinding 30-60min, be aged 60-180min, after material naturally cools to room temperature, dispensed to get.The advantages that periodontitis effect is good is sterilized and treated to subprostrate sophora pseudo-ginseng herbal mixture toothpaste produced by the present invention with high security,.
Description
Technical field
The present invention relates to Chinese medicinal toothpaste fields.It is more particularly related to a kind of subprostrate sophora pseudo-ginseng herbal mixture tooth
Cream and preparation method thereof.
Background technique
Subprostrate sophora (Classification system: Euchresta japonica), alias: three leaflet subprostrate sophoras, lima bean lotus, pulse family, mountain
Beans root platymiscium, have it is clearing heat and detoxicating, reduce swelling relieving sore-throat, cure mainly abscess of throat, gingivitis, aphthae.Subprostrate sophora is extracted
Object is used for existing research report in toothpaste, but since the matrine in subprostrate sophora is both functional component and toxic component how
On the basis of reducing sophorae subprostratae radix extract additive amount, keep subprostrate sophora Chinese medicinal toothpaste the effect of, to improve subprostrate sophora Chinese medicine tooth
The safety of cream becomes subprostrate sophora in toothpaste application field urgent problem.
Summary of the invention
The object of the present invention is to provide a kind of subprostrate sophora pseudo-ginseng herbal mixture toothpaste, by subprostrate sophora alkaloid extract with
Pseudo-ginseng total saponins compounding while guaranteeing subprostrate sophora Chinese medicinal toothpaste effect, is significantly reduced using the synergistic function of the two
The additive amount of subprostrate sophora alkaloid extract, it is highly-safe.
In order to realize purposes and other advantages according to the present invention, a kind of subprostrate sophora pseudo-ginseng herbal mixture toothpaste is provided,
Including subprostrate sophora pseudo-ginseng composition, the subprostrate sophora pseudo-ginseng composition accounts for the weight percent of subprostrate sophora pseudo-ginseng herbal mixture toothpaste
For 0.05-2%, the subprostrate sophora pseudo-ginseng composition is pseudo-ginseng total saponins and subprostrate sophora alkaloid extract.
Preferably, the subprostrate sophora pseudo-ginseng herbal mixture toothpaste, the subprostrate sophora pseudo-ginseng composition account for the mountain beans
The weight percent of root pseudo-ginseng herbal mixture toothpaste is 0.1-1%.
Preferably, the subprostrate sophora pseudo-ginseng herbal mixture toothpaste and preparation method thereof, the subprostrate sophora pseudo-ginseng combination
The weight percent that object accounts for the subprostrate sophora pseudo-ginseng herbal mixture toothpaste is 0.15-0.6%.
Preferably, the subprostrate sophora pseudo-ginseng herbal mixture toothpaste, in the subprostrate sophora pseudo-ginseng composition, the pseudo-ginseng
The weight ratio of total saposins and the subprostrate sophora alkaloid extract is 1:1-10.
Preferably, the subprostrate sophora pseudo-ginseng herbal mixture toothpaste, the preparation side of the subprostrate sophora alkaloid extract
Method are as follows: into the dry medicinal material of subprostrate sophora be added 7-10 times of weight amount water, at 98 ± 2 DEG C refluxing extraction twice, each 2h, mistake
Filter merges filtrate twice, and concentrates the filtrate in medicinal extract;It with the volumetric concentration of 2-3 times of weight amount is 20- by gained medicinal extract
Gained filtrate is added in macroreticular resin for 30% ethyl alcohol dissolution, filtering, and 3 column volumes are eluted with water, collect the 2nd and the 3rd
A cylinder ponding, concentrated it to after merging in medicinal extract to get.
Preferably, the subprostrate sophora pseudo-ginseng herbal mixture toothpaste, further includes toothpaste matrix comprising by weight
The following raw material of meter: 30-40 parts of calcium carbonate, 5-15 parts of D-sorbite, 1-10 parts of hydrated silica, 4-8 parts of glycerol, polyethylene glycol-8
0.3-1 parts, 1-3 parts of laruyl alcohol sodium sulfovinate, 1-3 parts of essence, 1-2 parts of cellulose gum, 0.05-0.1 parts of pseudo-ginseng total saponins, mountain beans
0.1-0.5 parts of root alkaloid extract, 0.1-0.3 parts of tranexamic acid, 0.5-1 parts of Chondrus crispus, 0.5-1 parts of saccharin sodium, hydroxyl
0.02-0.04 parts of 0.1-0.5 parts of benzene methyl, 0.1-0.5 parts of Nipasol and double hydroxy methylimidazole ureines, wherein calcium carbonate,
With physical technology of removing pollution power, it is equipped with correct teeth brushing way, plaque functions of whitening teeth can be desalinated, prevent deposition of dental calculus;Ammonia first ring
Acid, can effectively mitigate and prevent bleeding gums, oral hemorrhage etc., whitening effect is more preferable, moves back black except the effect of spot compares vitamin C
It is about 50 times high, it is nearly 10 times of tartaric acid or so;Double hydroxy methylimidazole ureines, can inhibit microbial reproduction, particularly in leather
Blue formula positive bacteria, Gram negative bacterium, including pseudomonad have fungistatic effect, selectively inhibit to saccharomycete, mould;Essence
Can for mint aroma, stay orchid odor type, Chinese ilex odor type, fruit flavouring, tea to feel well odor type etc., preferably mint aroma, with pure and fresh mouth
Gas, and improved when some sphagitis patients brush teeth using refrigerant throat-moistening specific to peppermint and fragrant pleasant smell and cause nausea
Sense of discomfort.
A kind of preparation method of subprostrate sophora pseudo-ginseng herbal mixture toothpaste, comprising: toothpaste is added in subprostrate sophora pseudo-ginseng composition
In matrix, after agitation grinding 30-60min, be aged 60-180min, after material naturally cools to room temperature, dispensed to get,
Wherein, it is 0.05-5% that the subprostrate sophora pseudo-ginseng composition, which accounts for the weight percent of subprostrate sophora pseudo-ginseng herbal mixture toothpaste, described
Subprostrate sophora pseudo-ginseng composition is made of pseudo-ginseng total saponins and subprostrate sophora alkaloid extract according to weight ratio 1:1-10.
Preferably, the preparation method of the subprostrate sophora pseudo-ginseng herbal mixture toothpaste, the subprostrate sophora alkaloid extract
Object the preparation method comprises the following steps: into the dry medicinal material of subprostrate sophora be added 7-10 times of weight amount water, at 98 ± 2 DEG C refluxing extraction twice,
Each 2h, filtering merge filtrate twice, and concentrate the filtrate in medicinal extract;Gained medicinal extract is dense with the volume of 2-3 times of weight amount
The ethyl alcohol that degree is 20-30% dissolves, and gained filtrate is added in macroreticular resin for filtering, and 3 column volumes are eluted with water, and collects the 2nd
A and the 3rd cylinder ponding, concentrated it to after merging in medicinal extract to get.
Preferably, the preparation method of the subprostrate sophora pseudo-ginseng herbal mixture toothpaste, the toothpaste matrix include by weight
Measure the following raw material of part meter: 30-40 parts of calcium carbonate, 5-15 parts of D-sorbite, 1-10 parts of hydrated silica, 4-8 parts of glycerol, poly- second two
- 8 0.3-1 parts of alcohol, 1-3 parts of laruyl alcohol sodium sulfovinate, 1-3 parts of essence, 1-2 parts of cellulose gum, pseudo-ginseng total saponins 0.05-0.1
Part, 0.1-0.5 parts of subprostrate sophora alkaloid extract, 0.1-0.3 parts of tranexamic acid, 0.5-1 parts of Chondrus crispus, saccharin sodium 0.5-
0.02-0.04 parts of 1 part, 0.1-0.5 parts of methyl hydroxybenzoate, 0.1-0.5 parts of Nipasol and double hydroxy methylimidazole ureines.
Preferably, the preparation method of the subprostrate sophora pseudo-ginseng herbal mixture toothpaste further includes, in agitation grinding process
In vacuumize, vacuum pressure be -0.096MPa.
The present invention is include at least the following beneficial effects:
The first, the present invention compounds subprostrate sophora alkaloid extract with pseudo-ginseng total saponins, is made using the synergy of the two
With significantly reducing the additive amount of subprostrate sophora alkaloid extract, safety while guaranteeing subprostrate sophora Chinese medicinal toothpaste effect
It is high;
The second, toothpaste of the invention can help to mitigate swelling and aching of gum, harmful bacteria is inhibited to breed, and control and maintain Oral Bacteria
The ecological balance of group is prevented and treated periodontitis and canker sore, is felt more comfortably using rear ability to speak, more safe and effective.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Specific embodiment
The present invention will be further described in detail below with reference to the embodiments, to enable those skilled in the art referring to specification
Text can be implemented accordingly.
It should be noted that experimental method described in following embodiments is unless otherwise specified conventional method, it is described
Reagent and material commercially obtain unless otherwise specified.
Embodiment 1
It prepares subprostrate sophora alkaloid extract: the water of 1700kg being added into the dry medicinal material of subprostrate sophora of 200kg, in 98 ± 2
Twice, each 2h, filtering merges filtrate twice, and filtrate is concentrated at 60 DEG C in medicinal extract refluxing extraction under DEG C (boiling);
Gained medicinal extract is dissolved with the ethyl alcohol that the volumetric concentration of 2.5 times of weight amounts is 20-30%, macropore is added in gained filtrate by filtering
In resin (model: D101), 3 column volumes are eluted with water, the 2nd and the 3rd cylinder ponding are collected, by it in 60 DEG C after merging
Under be concentrated into medicinal extract to get.
It prepares pseudo-ginseng total saponins: the ethyl alcohol that the volumetric concentration of 700L is 80% being added into the pseudo-ginseng coarse powder of 100kg, in 80
Twice, each 2h, filtering merges filtrate twice to refluxing extraction, and by after filtrate film separation system refined filtration, takes under filter at DEG C
Object, be concentrated at 60 DEG C in medicinal extract to get.
Embodiment 2
Pseudo-ginseng total saponins 1.0g, subprostrate sophora the alkaloid extract 1.0g, calcium carbonate 30g, sorbose of the preparation of Example 1
Alcohol 15g, hydrated silica 10g, glycerol 4g, polyethylene glycol-8 1g, laruyl alcohol sodium sulfovinate 3g, Chinese ilex essence 2g, cellulose gum 2g,
Tranexamic acid 0.3g, Chondrus crispus 1g, saccharin sodium 0.5g, methyl hydroxybenzoate 0.5g, Nipasol 0.1g and double hydroxy methylimidazoles
Ureine 0.04g, based on 100g weight, residue plus deionized water are stirred grinding 60min, are stirring Chinese medicinal toothpaste to 100g
It mixes in process of lapping and vacuumizes (pressure is -0.096Mpa), be finally aged 180min, after material naturally cools to room temperature, into
Row packing, obtains subprostrate sophora pseudo-ginseng herbal mixture toothpaste.
Embodiment 3
Pseudo-ginseng total saponins 0.2g, subprostrate sophora the alkaloid extract 0.8g, calcium carbonate 40g, sorbose of the preparation of Example 1
Alcohol 10g, hydrated silica 10g, glycerol 4g, polyethylene glycol-8 1g, laruyl alcohol sodium sulfovinate 3g, blueberry flavor 1g, cellulose gum
1g, tranexamic acid 0.3g, Chondrus crispus 1g, saccharin sodium 1g, methyl hydroxybenzoate 0.1g, Nipasol 0.1g and double hydroxy methylimidazoles
Ureine 0.02g, based on 100g weight, residue plus deionized water are stirred grinding 30min, are stirring Chinese medicinal toothpaste to 100g
It mixes in process of lapping and vacuumizes (pressure is -0.096Mpa), be finally aged 60min, after material naturally cools to room temperature, carry out
Packing, obtains subprostrate sophora pseudo-ginseng herbal mixture toothpaste.
Embodiment 4
Pseudo-ginseng total saponins 0.08g, subprostrate sophora the alkaloid extract 0.25g, calcium carbonate 35g, sorb of the preparation of Example 1
Sugar alcohol 10g, hydrated silica 5g, glycerol 6g, polyethylene glycol-8 0.5g, laruyl alcohol sodium sulfovinate 2g, orchid compound 2g, fiber are stayed
Plain glue 1.5g, tranexamic acid 0.2g, Chondrus crispus 0.8g, saccharin sodium 0.8g, methyl hydroxybenzoate 0.3g, Nipasol 0.3g and double
Hydroxy methylimidazole ureine 0.03g, for Chinese medicinal toothpaste based on 100g weight, residue plus deionized water are stirred grinding to 100g
45min vacuumizes (pressure is -0.096Mpa) during agitation grinding, is finally aged 120min, naturally cools to material
It after room temperature, is dispensed, obtains subprostrate sophora pseudo-ginseng herbal mixture toothpaste.
Embodiment 5
Pseudo-ginseng total saponins 0.05g, subprostrate sophora the alkaloid extract 0.1g, calcium carbonate 30g, sorb of the preparation of Example 1
Sugar alcohol 15g, hydrated silica 10g, glycerol 8g, polyethylene glycol-8 0.3g, laruyl alcohol sodium sulfovinate 1g, essence 3g, cellulose gum
2g, tranexamic acid 0.1g, Chondrus crispus 0.5g, saccharin sodium 0.5g, methyl hydroxybenzoate 0.1g, Nipasol 0.1g, double methylols
Imidazolidinyl urea 0.02g, based on 100g weight, residue plus deionized water are stirred and grind to 100g Chinese medicinal toothpaste
45min vacuumizes (pressure is -0.096Mpa) in whipping process, finally carries out ageing 80min, naturally cool to material
Room temperature is dispensed, and subprostrate sophora pseudo-ginseng herbal mixture toothpaste 1 is obtained.
Embodiment 6
Pseudo-ginseng total saponins 0.1g, subprostrate sophora the alkaloid extract 0.5g, calcium carbonate 40g, sorbose of the preparation of Example 1
Alcohol 15g, hydrated silica 10g, glycerol 8g, polyethylene glycol-8 0.3g, laruyl alcohol sodium sulfovinate 1g, essence 3g, cellulose gum 2g,
Tranexamic acid 0.1g, Chondrus crispus 0.5g, saccharin sodium 0.5g, methyl hydroxybenzoate 0.5g, Nipasol 0.5g, bis- (methylol) miaows
Oxazolidinyl urea 0.04g, Chinese medicinal toothpaste is based on 100g weight, remaining plus deionized water to 100g, is stirred and grinds 60min,
(pressure is -0.096Mpa) is vacuumized in whipping process, finally carries out ageing 150min, material is made to naturally cool to room temperature,
It is dispensed, obtains subprostrate sophora pseudo-ginseng herbal mixture toothpaste 2.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 6, and difference is, is only added to pseudo-ginseng total saponins, is not added with subprostrate sophora biology
The additive amount of alkali extract, pseudo-ginseng total saponins is 0.6g, obtains Chinese medicinal toothpaste D1.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 6, and difference is, is only added to subprostrate sophora alkaloid extract, is not added with field
The additive amount of seven total saposins, subprostrate sophora alkaloid extract is 0.6g, obtains Chinese medicinal toothpaste D2.
Comparative example 3
Comparative example 3 is substantially the same manner as Example 6, and difference is, pseudo-ginseng total saponins and subprostrate sophora alkaloid extract are replaced
It is changed to deionized water, obtains blank toothpaste K1.
Experimental example 1
By toothpaste made from subprostrate sophora pseudo-ginseng herbal mixture toothpaste made from the embodiment of the present invention 5,6 and comparative example 1-3 into
The test of row bactericidal effect, test method are as follows: by (9-10) × 104The bacterium solution of cfu/g is uniformly coated on plate, then will
Toothpaste is equably applied to planar surface, together incubation time 10 minutes, measures bacteria living quantity (unit cfu/ on plate
G), by the amount of survival compared with bacterial number in original bacteria liquid, antibiotic rate (%) is obtained, the results are shown in Table 1.
The sterilizing rate (%) of 1 toothpaste of table
Toothpaste | 1 | 2 | D1 | D2 | K1 |
Escherichia coli | 99.6 | 99.9 | 89.1 | 89.4 | 85.0 |
Golden yellow staphylococcus | 99.5 | 99.8 | 80.7 | 82.3 | 78.3 |
Candida albicans | 99.6 | 99.9 | 76.3 | 81.2 | 75.7 |
Streptococcus mutans | 99.5 | 99.7 | 79.9 | 82.5 | 80.5 |
As shown in Table 1, subprostrate sophora pseudo-ginseng herbal mixture toothpaste made from the embodiment of the present invention 5,6 is to Escherichia coli, golden yellow
The sterilizing rate of color staphylococcus, Candida albicans and Streptococcus mutans is obviously higher than comparative example.
Experimental example 2
By toothpaste made from subprostrate sophora pseudo-ginseng herbal mixture toothpaste made from the embodiment of the present invention 5,6 and comparative example 1-3 into
Row treatment periodontitis measure of merit, test method is as follows: 100 patients with periodontitis chosen, are randomly divided into 5 groups, every group of 20 people, often
People is sooner or later each primary using test toothpaste daily, is used continuously 2 months, using preceding and using after 2 months, carries out oral cavity to everyone
It checks and gingival index is used to score, standards of grading are as follows: 1- no inflammation;2- mild inflammation, gum color and quality are omited
It changes;3- moderate inflammation, gum is bright, red, swollen, hyperplasia;4- hyperphlogosis, the obvious rubescent, hyperplasia of gum have spontaneity to go out
Blood makees average value to appraisal result, the results are shown in Table 2.
Table 2 treats periodontitis effect
Toothpaste | 1 | 2 | D1 | D2 | K1 |
Use preceding average value | 3.5 | 3.8 | 3.6 | 3.5 | 3.9 |
Use rear average value | 1.9 | 1.6 | 2.8 | 2.5 | 3.5 |
As shown in Table 2, subprostrate sophora pseudo-ginseng herbal mixture toothpaste made from the embodiment of the present invention 5,6 has good treatment tooth
The effect of Zhou Yan.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (10)
1. subprostrate sophora pseudo-ginseng herbal mixture toothpaste, which is characterized in that including subprostrate sophora pseudo-ginseng composition, the subprostrate sophora pseudo-ginseng group
Closing object and accounting for the weight percent of subprostrate sophora pseudo-ginseng herbal mixture toothpaste is 0.05-2%, and the subprostrate sophora pseudo-ginseng composition is pseudo-ginseng
Total saposins and subprostrate sophora alkaloid extract.
2. subprostrate sophora pseudo-ginseng herbal mixture toothpaste as described in claim 1, which is characterized in that the subprostrate sophora pseudo-ginseng composition
The weight percent for accounting for the subprostrate sophora pseudo-ginseng herbal mixture toothpaste is 0.1-1%.
3. subprostrate sophora pseudo-ginseng herbal mixture toothpaste as claimed in claim 2 and preparation method thereof, which is characterized in that the mountain beans
The weight percent that root pseudo-ginseng composition accounts for the subprostrate sophora pseudo-ginseng herbal mixture toothpaste is 0.15-0.6%.
4. subprostrate sophora pseudo-ginseng herbal mixture toothpaste a method according to any one of claims 1-3, which is characterized in that the subprostrate sophora pseudo-ginseng
In composition, the weight ratio of the pseudo-ginseng total saponins and the subprostrate sophora alkaloid extract is 1:1-10.
5. subprostrate sophora pseudo-ginseng herbal mixture toothpaste a method according to any one of claims 1-3, which is characterized in that the subprostrate sophora biology
Alkali extract the preparation method comprises the following steps: into the dry medicinal material of subprostrate sophora be added 7-10 times of weight amount water, the refluxing extraction at 98 ± 2 DEG C
Twice, each 2h, filtering merge filtrate twice, and concentrate the filtrate in medicinal extract;By gained medicinal extract 2-3 times of weight amount
The ethyl alcohol that volumetric concentration is 20-30% dissolves, and gained filtrate is added in macroreticular resin, 3 column volumes are eluted with water by filtering,
Collect the 2nd and the 3rd cylinder ponding, concentrated it to after merging in medicinal extract to get.
6. subprostrate sophora pseudo-ginseng herbal mixture toothpaste a method according to any one of claims 1-3, which is characterized in that further include toothpaste base
Body comprising the following raw material by weight: 30-40 parts of calcium carbonate, 5-15 parts of D-sorbite, 1-10 parts of hydrated silica, sweet
4-8 parts oily, 0.3-1 parts of polyethylene glycol-8,1-3 parts of laruyl alcohol sodium sulfovinate, 1-3 parts of essence, 1-2 parts of cellulose gum, pseudo-ginseng are total
0.05-0.1 parts of saponin(e, 0.1-0.5 parts of subprostrate sophora alkaloid extract, 0.1-0.3 parts of tranexamic acid, Chondrus crispus 0.5-1
Part, 0.5-1 parts of saccharin sodium, 0.1-0.5 parts of methyl hydroxybenzoate, 0.1-0.5 parts of Nipasol and double hydroxy methylimidazole ureine 0.02-
0.04 part.
7. the preparation method of subprostrate sophora pseudo-ginseng herbal mixture toothpaste characterized by comprising subprostrate sophora pseudo-ginseng composition to be added
In toothpaste matrix, after agitation grinding 30-60min, ageing 60-180min is dispensed after material naturally cools to room temperature,
To obtain the final product, wherein the weight percent that the subprostrate sophora pseudo-ginseng composition accounts for subprostrate sophora pseudo-ginseng herbal mixture toothpaste is 0.05-5%,
The subprostrate sophora pseudo-ginseng composition is made of pseudo-ginseng total saponins and subprostrate sophora alkaloid extract according to weight ratio 1:1-10.
8. the preparation method of subprostrate sophora pseudo-ginseng herbal mixture toothpaste as claimed in claim 7, which is characterized in that the subprostrate sophora
Alkaloid extract the preparation method comprises the following steps: into the dry medicinal material of subprostrate sophora be added 7-10 times of weight amount water, flow back at 98 ± 2 DEG C
It extracts twice, each 2h, filtering merges filtrate twice, and concentrates the filtrate in medicinal extract;By gained medicinal extract 2-3 times of weight
The ethyl alcohol that the volumetric concentration of amount is 20-30% dissolves, and gained filtrate is added in macroreticular resin, 3 cylinders are eluted with water by filtering
Product, collect the 2nd and the 3rd cylinder ponding, concentrated it to after merging in medicinal extract to get.
9. the preparation method of subprostrate sophora pseudo-ginseng herbal mixture toothpaste as claimed in claim 7, which is characterized in that the toothpaste base
Body includes the following raw material by weight: 30-40 parts of calcium carbonate, 5-15 parts of D-sorbite, 1-10 parts of hydrated silica, glycerol 4-
8 parts, 0.3-1 parts of polyethylene glycol-8,1-3 parts of laruyl alcohol sodium sulfovinate, 1-3 parts of essence, 1-2 parts of cellulose gum, pseudo-ginseng total saponins
0.05-0.1 parts, 0.1-0.5 parts of subprostrate sophora alkaloid extract, 0.1-0.3 parts of tranexamic acid, 0.5-1 parts of Chondrus crispus, sugar
Smart sodium 0.5-1 parts, 0.1-0.5 parts of methyl hydroxybenzoate, 0.1-0.5 parts of Nipasol and double hydroxy methylimidazole ureine 0.02-0.04
Part.
10. the preparation method of subprostrate sophora pseudo-ginseng herbal mixture toothpaste as claimed in claim 7, which is characterized in that further include,
It is vacuumized during agitation grinding, vacuum pressure is -0.096MPa.
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Application publication date: 20190514 Assignee: GUANGXI HENGDERUN BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Assignor: GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS Contract record no.: X2023980045685 Denomination of invention: Shandougen Tianqi Compound Traditional Chinese Medicine Toothpaste and Its Preparation Method Granted publication date: 20210824 License type: Common License Record date: 20231106 |