CN111249289A - Oral care product or medicament for anti-inflammation and/or anti-allergy - Google Patents
Oral care product or medicament for anti-inflammation and/or anti-allergy Download PDFInfo
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- CN111249289A CN111249289A CN202010093186.5A CN202010093186A CN111249289A CN 111249289 A CN111249289 A CN 111249289A CN 202010093186 A CN202010093186 A CN 202010093186A CN 111249289 A CN111249289 A CN 111249289A
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- oral care
- care product
- toothpaste
- medicament
- saponin
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- 239000003814 drug Substances 0.000 title claims abstract description 29
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 26
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 18
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 21
- OUHBKBTZUPLIIA-OTEDBJMHSA-N [(2s,3r,4s,5s,6r)-6-[[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (1r,3as,5ar,5br,7ar,8r,9s,11ar,11br,13ar,13br)-9-[(2s,3r,4s,5s)-4,5-dihydroxy- Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)[C@H](OC(=O)[C@@]34[C@H]([C@@H](CC3)C(C)=C)[C@@H]3[C@@]([C@]5(C)CC[C@H]6[C@](C)(CO)[C@@H](O[C@H]7[C@@H]([C@@H](O)[C@@H](O)CO7)O[C@H]7[C@@H]([C@H](O)[C@@H](O)[C@H](C)O7)O)CC[C@]6(C)[C@H]5CC3)(C)CC4)O2)O)[C@H](O)[C@H]1O OUHBKBTZUPLIIA-OTEDBJMHSA-N 0.000 claims abstract description 19
- 230000004054 inflammatory process Effects 0.000 claims abstract description 11
- 208000002193 Pain Diseases 0.000 claims abstract description 9
- 230000000740 bleeding effect Effects 0.000 claims abstract description 9
- 230000036407 pain Effects 0.000 claims abstract description 9
- 229940034610 toothpaste Drugs 0.000 claims description 52
- 239000000606 toothpaste Substances 0.000 claims description 52
- 239000002324 mouth wash Substances 0.000 claims description 9
- 229940051866 mouthwash Drugs 0.000 claims description 9
- 241000123887 Pulsatilla chinensis Species 0.000 claims description 7
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 7
- 229930182490 saponin Natural products 0.000 claims description 7
- 150000007949 saponins Chemical class 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 239000004088 foaming agent Substances 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical group CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 3
- 239000002304 perfume Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 3
- 229940081974 saccharin Drugs 0.000 claims description 3
- 235000019204 saccharin Nutrition 0.000 claims description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 235000013599 spices Nutrition 0.000 claims description 2
- 208000032843 Hemorrhage Diseases 0.000 abstract description 8
- 208000034158 bleeding Diseases 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
- 208000026935 allergic disease Diseases 0.000 abstract description 2
- 230000007815 allergy Effects 0.000 abstract description 2
- 230000003467 diminishing effect Effects 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 9
- 230000001680 brushing effect Effects 0.000 description 8
- 206010042674 Swelling Diseases 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 229930184121 pulsatilla saponin Natural products 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 230000000474 nursing effect Effects 0.000 description 3
- 206010018276 Gingival bleeding Diseases 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 208000006770 Ascorbic Acid Deficiency Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010018286 Gingival pain Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 206010047623 Vitamin C deficiency Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 208000011759 gum bleeding Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Birds (AREA)
- Hematology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides an anti-inflammatory and/or anti-allergic oral care product or medicine, which comprises pulsatilla saponin B4. The invention also provides application of the pulsatilla saponin B4 in preparing anti-inflammatory and/or anti-allergic oral care products or medicines. The experimental result shows that the pulsatilla saponin B4 is added into the oral care product, so that the inflammation, pain and inflammation of the gum can be treated, the bleeding symptom of the gum can be treated, and the anti-inflammation and anti-allergy effects of the oral care product can be obviously improved in a short time. Therefore, the pulsatilla saponin B4 has a very good application prospect in preparing oral care products or medicines for diminishing inflammation and resisting allergy by being used as an active ingredient.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to an anti-inflammatory and/or anti-allergic oral care product or medicine.
Background
In China, 90% of adults have oral problems of different degrees, professional medical statistical data show that with the change of eating habits and the increase of working pressure, oral problems such as oral ulcer, tooth openness and swelling pain, bleeding and atrophy are spreading rapidly, and meanwhile, common oral diseases such as gingivitis, periodontitis and alveolar abscess caused by chemical drugs, burns, vitamin C deficiency, bacterial growth in oral cavities and the like are increasing.
In order to prevent or alleviate the above oral problems in daily life, there are commercially available oral care products such as antiallergic toothpaste, anti-inflammatory mouth wash, etc. which are full of precious minerals. However, most of the existing functional oral care products only have a single nursing effect, and are difficult to truly play the roles of diminishing inflammation and resisting allergy at the same time. Moreover, most of the existing functional oral care products have the problems of complex components, slow effect and unobvious effect, and can not meet the requirements of consumers.
Therefore, a new product capable of nursing the oral cavity quickly and variously is developed, and the novel oral cavity nursing device has a very good prospect.
Disclosure of Invention
The object of the present invention is to provide a new anti-inflammatory and/or anti-allergic oral care product or medicament.
The invention provides an anti-inflammatory and/or anti-allergic oral care product or medicine, which comprises pulsatilla saponin B4.
Furthermore, in the oral care product or the medicine, the weight ratio of the pulsatilla saponin B4 is more than 0.5 per thousand.
Furthermore, in the oral care product or the medicine, the weight ratio of the pulsatilla saponin B4 is 0.5-1 per thousand.
Further, the oral care product is a toothpaste or a mouthwash.
Further, the toothpaste is prepared from the pulsatilla saponin B4 and other components, wherein the other components comprise an abrasive, a humectant, a foaming agent, a binder, a spice, a sweetener, a preservative and water;
preferably, the friction agent is calcium carbonate, the humectant is sorbitol, the foaming agent is sodium lauryl sulfate, the binder is sodium carboxymethylcellulose, the sweetener is saccharin, and the preservative is ethylparaben.
Further, in the rest of the components, the content of the abrasive is 37.0-41.0 wt.%, preferably 39.0 wt.%; the humectant content is 20.0-24.0 wt.%, preferably 22.0 wt.%; the content of the foaming agent is 1.0-1.5 wt.%, preferably 1.3 wt.%; the content of the adhesive is 1.0-1.2 wt.%, preferably 1.1 wt.%; the perfume content is 0.8-1.2 wt.%, preferably 1.0 wt.%; the content of the sweetening agent is 0.05-0.15 wt.%, preferably 0.10 wt.%; the content of the preservative is less than 0.3 wt.%; the remainder was water.
The invention also provides application of the pulsatilla saponin B4 in preparing anti-inflammatory and/or anti-allergic oral care products or medicines.
Furthermore, in the oral care product or the medicine, the weight ratio of the pulsatilla saponin B4 is more than 0.5 per thousand, and preferably 0.5 to 1 per thousand.
Further, the oral care product is a toothpaste or a mouthwash.
Further, the oral care product or medicament is capable of treating inflammation, pain, redness and/or bleeding of the gums.
The structure of the pulsatilla saponin B4 is as follows:
the experimental result shows that the pulsatilla saponin B4 is added into the toothpaste or the mouthwash to treat the symptoms of inflammation, pain and red swelling of the gum and the bleeding of the gum, and the anti-inflammatory and anti-allergic effects of the toothpaste or the mouthwash are remarkably improved in a short time. Therefore, the pulsatilla saponin B4 has a very good application prospect in preparing anti-inflammatory and/or anti-allergic oral care products by being used as an active ingredient.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
The raw materials and equipment used in the invention are known products and are obtained by purchasing commercial products.
Wherein, the pulsatilla saponin B4 (purity is more than 99.5%) is obtained by purchase.
EXAMPLE 1 preparation of a mouthwash according to the invention
Adding the pulsatilla chinensis saponin B4 into physiological saline, uniformly mixing, and controlling the weight ratio of pulsatilla chinensis saponin B4 to be 0.5 per thousand or 1 per thousand of the total weight to respectively obtain 0.5 per thousand or 1 per thousand of mouthwash of the invention.
Example 2 preparation of a toothpaste according to the invention
Adding the pulsatilla chinensis saponin B4 into the untreated toothpaste, and uniformly mixing, wherein the weight ratio of the pulsatilla chinensis saponin B4 is controlled to be 0.5 per thousand or 1 per thousand of the total weight, so as to respectively obtain 0.5 per thousand toothpaste or 1 per thousand toothpaste.
Wherein the untreated toothpaste is a regular toothpaste prepared from calcium carbonate (39.0 wt.%), sorbitol (22.0 wt.%), sodium carboxymethylcellulose (1.1 wt.%), sodium lauryl sulfate (1.3 wt.%), saccharin (0.1 wt.%), perfume (1.0 wt.%), ethylparaben (less than 0.3 wt.%) and deionized water.
The beneficial effects of the present invention are demonstrated by the following experimental examples.
Experimental example 1 anti-inflammatory Effect test of toothpaste according to the present invention
(1) Test objects: randomly taking 15 patients from the patient sample; symptoms are: inflammation, pain, redness and swelling of the gums.
(2) Test samples: 0.5 per mill toothpaste and 1 per mill toothpaste prepared in the embodiment 2 of the invention; commercially available anti-inflammatory toothpaste (gaolujie).
(3) The experimental method comprises the following steps: the patients were randomly divided into 3 groups, the first group was used for brushing teeth with commercially available anti-inflammatory toothpaste, the second group was used for brushing teeth with 0.5 ‰ toothpaste, and the third group was used for brushing teeth with 1 ‰ toothpaste for 2 times per day, with the toothpaste amount of 2cm each time and the tooth brushing time of 5min each time. And observing the recovery condition and the recovery time of the gum of the patient.
The healing standard is as follows: the gum pain disappeared and the redness and swelling subsided.
(4) Results of the experiment
The results are shown in table 1, on the 3 rd day of the experiment, no obvious anti-inflammatory effect is achieved after the commercial toothpaste is used, but the pain of the patient is weakened after the 0.5 per mill toothpaste is used, the red swelling of the patient is relieved after the 1 per mill toothpaste is used, and the anti-inflammatory effect is obvious. The toothpaste can cure inflammation, pain and swelling of the gum of a patient within 5 days, the anti-inflammation effect of the toothpaste is superior to that of the commercially available anti-inflammation toothpaste, and the anti-inflammation effect of 1 per mill of the toothpaste is superior to that of 0.5 per mill of the toothpaste.
The experiments show that the anti-inflammatory effect of the toothpaste can be obviously improved by adding the pulsatilla saponin into the toothpaste, and the anti-inflammatory effect is enhanced along with the increase of the addition amount of the pulsatilla saponin.
TABLE 1 comparison of anti-inflammatory effects
Experimental example 2 antiallergic effect test of toothpaste of the present invention
(1) Test objects: randomly taking 15 patients from the patient sample; symptoms are: the gum is prone to bleeding and sensitive to cold and heat.
(2) Test samples: 0.5 per mill toothpaste and 1 per mill toothpaste prepared in the embodiment 2 of the invention; commercially available anti-allergic toothpaste (gaolujie).
(3) The experimental method comprises the following steps: the patients were randomly divided into 3 groups, the first group was used for brushing teeth with commercially available antiallergic toothpaste, the second group was used for brushing teeth with 0.5 ‰ toothpaste, and the third group was used for brushing teeth with 1 ‰ toothpaste for 2 times per day, with the toothpaste amount of 2cm for each time, and the tooth brushing time of 5min for each time. And observing the recovery condition and the recovery time of the gum of the patient.
The healing standard is as follows: the bleeding gum disappears.
(4) Results of the experiment
The results are shown in table 2, on the 7 th day of the experiment, the gingival bleeding of patients after using the toothpaste of the invention is obviously improved, while patients after using the commercially available toothpaste have no obvious effect; on the 15 th day of the experiment, the bleeding frequency of the patient after the commercial toothpaste is used is reduced, but the patient is not cured, and the gum bleeding of the patient after the 0.5 per mill toothpaste or the 1 per mill toothpaste is used disappears and is cured. Obviously, the antiallergic effect of the toothpaste prepared by the invention is better than that of the commercial antiallergic toothpaste, and the antiallergic effect of 1 per mill of the toothpaste is better than that of 0.5 per mill of the toothpaste.
The experiments show that the toothpaste can remarkably improve the anti-allergic effect by adding the pulsatilla saponin into the toothpaste, and the anti-allergic effect is enhanced along with the increase of the addition amount of the pulsatilla saponin.
TABLE 2 comparison of antiallergic Effect
In summary, the present invention provides an anti-inflammatory and anti-allergic oral care product or medicament comprising pasqueoside B4. The experimental result shows that the pulsatilla saponin B4 is added into the oral care product, so that the inflammation, pain and inflammation of the gum can be treated, the bleeding symptom of the gum can be treated, and the anti-inflammation and anti-allergy effects of the oral care product can be obviously improved in a short time. Therefore, the pulsatilla saponin B4 has a very good application prospect in preparing anti-inflammatory and/or anti-allergic oral care products or medicines as an active ingredient.
Claims (10)
1. An anti-inflammatory and/or anti-allergic oral care product or medicament, characterized in that: the oral care product or the medicine comprises pulsatilla saponin B4.
2. The oral care product or medicament of claim 1, wherein: in the oral care product or the medicine, the weight ratio of the pulsatilla chinensis saponin B4 is more than 0.5 per mill.
3. The oral care product or medicament of claim 1, wherein: in the oral care product or the medicine, the weight ratio of the pulsatilla chinensis saponin B4 is 0.5-1 per mill.
4. An oral care product or medicament according to any one of claims 1 to 3, wherein: the oral care product is a toothpaste or mouthwash.
5. The oral care product or medicament of claim 4, wherein: the toothpaste is prepared from the pulsatilla saponin B4 and other components, wherein the other components comprise an abrasive, a humectant, a foaming agent, an adhesive, a spice, a sweetener, a preservative and water;
preferably, the friction agent is calcium carbonate, the humectant is sorbitol, the foaming agent is sodium lauryl sulfate, the binder is sodium carboxymethylcellulose, the sweetener is saccharin, and the preservative is ethylparaben.
6. The oral care product or medicament of claim 5, wherein: in the rest components, the content of the abrasive is 37.0-41.0 wt.%, preferably 39.0 wt.%; the humectant content is 20.0-24.0 wt.%, preferably 22.0 wt.%; the content of the foaming agent is 1.0-1.5 wt.%, preferably 1.3 wt.%; the content of the adhesive is 1.0-1.2 wt.%, preferably 1.1 wt.%; the perfume content is 0.8-1.2 wt.%, preferably 1.0 wt.%; the content of the sweetening agent is 0.05-0.15 wt.%, preferably 0.10 wt.%; the content of the preservative is less than 0.3 wt.%; the remainder was water.
7. Use of pulsatilla saponin B4 in the preparation of an anti-inflammatory and/or anti-allergic oral care product or medicament.
8. Use according to claim 7, characterized in that: in the oral care product or the medicine, the weight ratio of the pulsatilla chinensis saponin B4 is more than 0.5 per thousand, preferably 0.5 per thousand to 1 per thousand.
9. Use according to claim 7, characterized in that: the oral care product is a toothpaste or mouthwash.
10. Use according to any one of claims 7 to 9, characterized in that: the oral care product or medicament is capable of treating inflammation, pain, redness and/or bleeding of the gums.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010093186.5A CN111249289A (en) | 2020-02-14 | 2020-02-14 | Oral care product or medicament for anti-inflammation and/or anti-allergy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010093186.5A CN111249289A (en) | 2020-02-14 | 2020-02-14 | Oral care product or medicament for anti-inflammation and/or anti-allergy |
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| Publication Number | Publication Date |
|---|---|
| CN111249289A true CN111249289A (en) | 2020-06-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010093186.5A Pending CN111249289A (en) | 2020-02-14 | 2020-02-14 | Oral care product or medicament for anti-inflammation and/or anti-allergy |
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| Country | Link |
|---|---|
| CN (1) | CN111249289A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318002A (en) * | 2021-06-12 | 2021-08-31 | 广西馨海药业科技有限公司 | Anti-inflammation acne-removing composition and cosmetic |
| CN114452292A (en) * | 2022-01-28 | 2022-05-10 | 中国中医科学院中药研究所 | Application of pulsatilla saponin B4 in preparation of skin care products |
| CN114469969A (en) * | 2022-01-28 | 2022-05-13 | 中国中医科学院中药研究所 | Application of pulsatilla saponin B5 in preparation of skin care products |
| EP4238570A4 (en) * | 2022-01-18 | 2024-06-05 | Guangxi Xinhai Pharmaceutical Technology Co., Ltd | Hair growth promoting composition, hair growth promoting drug and use |
Citations (11)
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