CN110101638A - A kind of anti-inflammatory antiallergy toothpaste - Google Patents
A kind of anti-inflammatory antiallergy toothpaste Download PDFInfo
- Publication number
- CN110101638A CN110101638A CN201910493202.7A CN201910493202A CN110101638A CN 110101638 A CN110101638 A CN 110101638A CN 201910493202 A CN201910493202 A CN 201910493202A CN 110101638 A CN110101638 A CN 110101638A
- Authority
- CN
- China
- Prior art keywords
- extract
- added
- toothpaste
- spice
- inflammatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of anti-inflammatory antiallergy toothpaste, is made of by weight percentage following components: chitosan oligosaccharide 2~8%, pinellia tuber extract 0.6-5%, silver perfume (or spice) extract 0.5-1.2%, the moisturizer of cimicifuga foetida extract 0.4-6%, 20-30%, the abrasive of 40-50%, the thickener of 0.6-2%, the surfactant of 1.5-2.5%, the sweetener of 0.1-0.5%, the preservative of 0.1-0.5%, the essence of 1-1.5%, deionized water are added to 100%.The present invention also provides the preparation methods of the Chinese medicinal toothpaste.The present invention passes through compounded technology, make toothpaste in the cleaning oral cavity with toothpaste itself, have while fresh breath and mitigates gum periodontitis symptom such as redness, bleeding, and it to canker sore, has a toothache and sensitivity of tooth has preventive and therapeutic action, improve tooth to resist to external cold and hot sour-sweet stimulation, mildly nurses oral environment, not damage tooth, ingredient is safe and effective, is with a wide range of applications.
Description
Technical field
The present invention relates to a kind of anti-inflammatory antiallergy toothpaste, belong to oral cavity cleaning and nursing field.
Background technique
Toothpaste is common cleaning supplies in daily life, there is very long history.With the continuous hair of science and technology
Exhibition, technological equipment continuously improve and it is perfect, various types of toothpaste are come out one after another, and the quality and grade of product is continuously improved,
Present toothpaste variety develops into great variety of goods, vdiverse in function by single clean type toothpaste, a brands up to a hundred it is multi-functional
Type toothpaste meets the needs of the different levels level of consumption.
In daily life, people often will appear the phenomenon that tooth meets hot and cold, sour, sweet tea and generates tingle, pain, this is just
Be it has often been said that sensitivity of tooth, tracing it to its cause mostly is to keep dentine sudden and violent since tooth abrasion, gingival atrophy, root of the tooth are exposed etc.
Caused by dew.Under external irritant, causes the endochylema protrusion of dentin cell to conduct and cause condition susceptible, it can also be because of dental pulp blood
The change of circulation, such as enamel wound, there is condition susceptible in the factors such as root of the tooth tip hyperemia, and with advancing age, tooth is quick
The frequency of sense is more prominent, seriously affects people's lives quality.And the teeth such as periodontitis, canker sore and enamel wound are scorching
Disease is also tooth common disease, these all bring certain slight illness, affect the normal life of people.
It is many for the product of odonthemodia currently on the market, it is substantially using sylvite or strontium salt technology and reaches closing
Or stop stimulation of the external irritant to dentine, to reduce pain.And comprehensive periodontitis, the gingivitis of being directed to is so cause
Pain and hypersensitive dentin caused by pain toothpaste it is seldom.One kind is developed for periodontitis, gingivitis so caused
The toothpaste of pain caused by pain and hypersensitive dentin just becomes a urgent problem to be solved.
Summary of the invention
The technical problem to be solved by the present invention is to overcome drawbacks described above, provide a kind of tooth with anti-inflammatory and anti-allergic effects
Cream and preparation method thereof, it contains four kinds of chitosan oligosaccharide, pinellia tuber extract, silver perfume (or spice) extract and cimicifuga foetida extract active constituents,
With good Synergistic antimicrobial effect and anti-allergic effects, toothpaste of the present invention can to periodontitis, canker sore, have a toothache and
Sensitivity of tooth has preventive and therapeutic action, while can enhance itself repair ability of oral cavity tissue, and strong gum improves micro- follow
Ring, healthy mouth improve the comprehensive antiallergy sense ability of tooth, are appropriate for promoting and applying.
The purpose of the invention is achieved by the following technical solution:
A kind of anti-inflammatory antiallergy toothpaste, the anti-inflammatory antiallergy toothpaste are made of by weight percentage following components: shell
Oligosaccharides 2~8%, pinellia tuber extract 0.6-5%, silver perfume (or spice) extract 0.5-1.2%, cimicifuga foetida extract 0.4-6%, 20-30%
Moisturizer, the abrasive of 40-50%, the thickener of 0.6-2%, the surfactant of 1.5-2.5%, the sweet tea of 0.1-0.5%
Taste agent, the preservative of 0.1-0.5%, the essence of 1-1.5%, deionized water are added to 100%.
Preferably, the anti-inflammatory antiallergy toothpaste is made of by weight percentage following components: chitosan oligosaccharide 5%, the tuber of pinellia
Extract 2%, silver perfume (or spice) extract 0.9%, cimicifuga foetida extract 3%, 28% moisturizer, 45% abrasive, 1.3% increasing
Thick dose, 2.0% surfactant, 0.3% sweetener, 0.3% preservative, 1.2% essence, deionized water is added to
100%.
The pinellia tuber extract the preparation method comprises the following steps:
By Pinellia Ternate dries pulverizing, the water for being equivalent to 6-12 times of weight of the tuber of pinellia is added, extracts 2 times at 70-90 DEG C, often
Secondary 2-3h, discards filter residue after filtering, extracting solution is concentrated under reduced pressure into relative density 1.20-1.30 after merging, its matter is added thereto
6-8 times of amount measures the dehydrated alcohol of volume, stands overnight, and supernatant is taken to be concentrated under reduced pressure into relative density 1.20-1.25, dry,
Up to pinellia tuber extract.
The silver perfume (or spice) extract the preparation method comprises the following steps:
Fragrant (iron holly bark) bark of silver or root skin dries pulverizing, addition are equivalent to silver perfume (or spice) 6-12 times of volume of weight
70% ethanol water extracts, refluxing extraction 2-3 times at 65-75 DEG C, and each extraction time is 1-3h, discards after filtering
Filter residue, merging filtrate are concentrated under reduced pressure into medicinal extract shape to constant weight, dry to get silver perfume (or spice) extract.
The cimicifuga foetida extract the preparation method comprises the following steps:
By cimicifugae foetidae medicinal material dries pulverizing, 70% ethanol water that 8-14 times of volume of cimicifugae foetidae weight is added is extracted,
Refluxing extraction 2-3 times at 65-75 DEG C, each extraction time are 1-3h, and combined extract is concentrated under reduced pressure into medicinal extract shape to constant weight, to
2-3 times of its quality n-hexane extraction for measuring volume is wherein added, removes lipid part, then the 2-3 of its quality is added thereto
The ethyl acetate extraction of amount volume again, extract liquor is concentrated under reduced pressure into medicinal extract to constant weight, dry to get cimicifuga foetida extract.
The moisturizer is one of sorbierite, glycerol, polyethylene glycol, propylene glycol or a variety of mixtures；
The abrasive is one of calcium carbonate, calcium monohydrogen phosphate, silica or a variety of mixtures；
The thickener is one of sodium carboxymethylcellulose, hydroxyethyl cellulose, xanthan gum, guar gum, carragheen
Or a variety of mixtures；
The surfactant is sldium lauryl sulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl sweet tea
One of dish alkali or a variety of mixtures.
The sweetener is one of saccharin sodium, button sweet tea, Sucralose, acesulfame potassium or a variety of mixtures；
The preservative is sodium benzoate, in methyl hydroxybenzoate, ethyl hydroxy benzoate, Nipasol, butyl hydroxybenzoate, methyl hydroxybenzoate sodium
One or more mixtures.
The chitosan oligosaccharide molecular weight is 1500Da~3000Da, and the degree of polymerization is 2~20.
A kind of preparation method of above-mentioned anti-inflammatory antiallergy toothpaste comprising following steps:
1) rubbing agent, thickener, sweetener and the preservative appropriate amount of deionized water for weighing formula ratio are uniformly mixed, and are made
Mixed liquor A is spare.
2) by the chitosan oligosaccharide of formula ratio, pinellia tuber extract, silver perfume (or spice) extract, cimicifuga foetida extract, surfactant and guarantor
Humectant be mixed evenly mixed liquid B is spare.
3) mixed liquid B is added in mixed liquor A, essence is then added, agitation grinding is sufficiently mixed creme uniformly, very
Sky degassing cream processed is packed up to the anti-inflammatory antiallergy toothpaste.
Anti-inflammatory antiallergy toothpaste of the present invention has following technical advantage:
(1) present invention uses chitosan oligosaccharide and the Chinese medicine with analgesia, anti-inflammatory, anti-allergic effects for primary efficacy preparation, makes
At the toothpaste for having both antibacterial anti-inflammatory and anti-allergic effects.For single active ingredient, the present composition has superposition
And syneryistic effect, each raw material complement each other, and play the synergistic effect between raw material, make anti-inflammatory and anti-allergic effects of the invention
Reach best.
(2) chitosan oligosaccharide has the function of antibacterial action and promotes wound healing, and it is for example red can to mitigate gum periodontitis symptom
Swollen, bleeding, and prevent and treat canker sore.Chitosan oligosaccharide generates natural metabolin by the intracorporal lysozyme degradation of biology,
Have the characteristics that it is nontoxic, can be fully absorbed by organism；Silver perfume (or spice) extract clearing heat and promoting diuresis, swelling and pain relieving have hemostasis and resist
Bacterium effect；Pinellia tuber extract has anti-inflammatory and anti-allergic effects；Cimicifuga foetida extract has antipyretic-antalgic, anti-inflammatory antipathogen, promotees
Into blood circulation, enhancing capillary function with formula in the tuber of pinellia mix be well ease pain desensitize drug.
(3) present invention has toothpaste while the cleaning oral cavity with toothpaste itself, fresh breath by compounded technology
Have and mitigate that gum periodontitis symptom is such as red and swollen, bleeding, and to canker sore, have a toothache and sensitivity of tooth has prevention and treatment to make
With improvement tooth is resisted to external cold and hot sour-sweet stimulation, mildly nurses oral environment, not damage tooth, ingredient is safe and effective.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the embodiment does not limit this hair in any way
The range of bright patent protection.
Embodiment 1
A kind of anti-inflammatory antiallergy toothpaste, the anti-inflammatory antiallergy toothpaste are made of by weight percentage following components: shell
Oligosaccharides 2%, pinellia tuber extract 0.6%, silver perfume (or spice) extract 0.5%, cimicifuga foetida extract 0.4%, 20% moisturizer (sorbierite
10%, glycerol 10%), 50% abrasive (calcium carbonate 50%), 0.6% thickener (sodium carboxymethylcellulose pyce 0.3%, hydroxyl second
Base cellulose 0.3%), 1.5% surfactant (sldium lauryl sulfate 0.8%, sodium lauroyl sarcosine 0.7%), 0.1%
Sweetener (saccharin sodium 0.1%), 0.1% preservative (sodium benzoate 0.05%, methyl hydroxybenzoate 0.05%), 1% essence,
Deionized water is added to 100%.
A kind of preparation method of above-mentioned anti-inflammatory antiallergy toothpaste the following steps are included:
1) rubbing agent, thickener, sweetener and the preservative appropriate amount of deionized water for weighing formula ratio are uniformly mixed, and are made
Mixed liquor A is spare.
2) by the chitosan oligosaccharide of formula ratio, pinellia tuber extract, silver perfume (or spice) extract, cimicifuga foetida extract, surfactant and guarantor
Humectant be mixed evenly mixed liquid B is spare.
3) mixed liquid B is added in mixed liquor A, essence is then added, agitation grinding is sufficiently mixed creme uniformly, very
Sky degassing cream processed is packed up to the anti-inflammatory antiallergy toothpaste.
Embodiment 2
A kind of anti-inflammatory antiallergy toothpaste, the anti-inflammatory antiallergy toothpaste are made of by weight percentage following components: shell
Oligosaccharides 8%, pinellia tuber extract 5%, silver perfume (or spice) extract 1.2%, cimicifuga foetida extract 6%, 30% moisturizer (polyethylene glycol
15%, propylene glycol 15%), 40% abrasive (calcium monohydrogen phosphate 40%), 2% thickener (xanthan gum 1%, guar gum 1%),
2.5% surfactant (sodium lauroyl glutamate 2.5%), 0.5% sweetener (Sucralose 0.5%), 0.5% it is anti-
Rotten agent (ethyl hydroxy benzoate 0.25%, Nipasol 0.25%), 1.5% essence, deionized water is added to 100%.
A kind of preparation method of above-mentioned anti-inflammatory antiallergy toothpaste the following steps are included:
1) rubbing agent, thickener, sweetener and the preservative appropriate amount of deionized water for weighing formula ratio are uniformly mixed, and are made
Mixed liquor A is spare.
2) by the chitosan oligosaccharide of formula ratio, pinellia tuber extract, silver perfume (or spice) extract, cimicifuga foetida extract, surfactant and guarantor
Humectant be mixed evenly mixed liquid B is spare.
3) mixed liquid B is added in mixed liquor A, essence is then added, agitation grinding is sufficiently mixed creme uniformly, very
Sky degassing cream processed is packed up to the anti-inflammatory antiallergy toothpaste.
Embodiment 3
A kind of anti-inflammatory antiallergy toothpaste, the anti-inflammatory antiallergy toothpaste are made of by weight percentage following components: shell
Oligosaccharides 5%, pinellia tuber extract 2%, silver perfume (or spice) extract 0.9%, cimicifuga foetida extract 3%, 28% moisturizer (propylene glycol
28%), 45% abrasive (silica 45%), 1.3% thickener (carragheen 1.3%), 2% surfactant
(cocoyl glycine betaine 2%), 0.3% sweetener (button sweet tea 0.3%), 0.3% preservative (butyl hydroxybenzoate 0.15%,
0.15% methyl hydroxybenzoate sodium), 1.2% essence, deionized water is added to 100%.
A kind of preparation method of above-mentioned anti-inflammatory antiallergy toothpaste the following steps are included:
1) rubbing agent, thickener, sweetener and the preservative appropriate amount of deionized water for weighing formula ratio are uniformly mixed, and are made
Mixed liquor A is spare.
2) by the chitosan oligosaccharide of formula ratio, pinellia tuber extract, silver perfume (or spice) extract, cimicifuga foetida extract, surfactant and guarantor
Humectant be mixed evenly mixed liquid B is spare.
3) mixed liquid B is added in mixed liquor A, essence is then added, agitation grinding is sufficiently mixed creme uniformly, very
Sky degassing cream processed is packed up to the anti-inflammatory antiallergy toothpaste.
Comparative example 1
In addition to being free of chitosan oligosaccharide in preparation prescription, remaining prescription and preparation method are the same as embodiment 3.
Comparative example 2
In addition to being free of pinellia tuber extract in preparation prescription, remaining prescription and preparation method are the same as embodiment 3.
Comparative example 3
In addition to being free of cimicifuga foetida extract in preparation prescription, remaining prescription and preparation method are the same as embodiment 3.
Comparative example 4
In addition to being free of silver perfume (or spice) extract in preparation prescription, remaining prescription and preparation method are the same as embodiment 3.
Anti-inflammatory antiallergy toothpaste of the present invention is detected by GB8372, result is qualification, and stability reaches
Placed 30-45 days at 45 DEG C, lotion do not return it is thick, do not separate, loss of gloss pool.
Sensory test: blind test is brushed teeth 100 person-times, feels 13 person-times slightly puckery, feels 12 person-times of bitter taste, remaining mouthfeel is can
Receive.
1 embodiment of the present invention of test example and comparative example prepare the bactericidal effect test method of resulting anti-inflammatory antiallergy toothpaste
It is as follows: the bacterium solution of (9-10) × 104cfu/g being uniformly coated on plate, then toothpaste is equably applied to plate table
Face.Incubation time 5 minutes together measure bacteria living quantity (unit cfu/g) on plate, will be in the amount of survival and original bacteria liquid
Bacterial number is compared, and sterilizing rate (%) is obtained.
The sterilizing rate (%) of the anti-inflammatory antiallergy toothpaste of the present invention of table 1
As it can be seen from table 1 anti-inflammatory antiallergy toothpaste of the invention has good bactericidal effect.
2 embodiment of the present invention of test example and comparative example prepare resulting anti-inflammatory antiallergy toothpaste paraxylene and cause small white mouse ear
The anti-inflammatory effect of corridor acute inflammation swelling
Healthy kind ♂ small white mouse 60, Kunming is chosen, is randomly divided into 6 groups, every group 10.When experiment, every group of every animal right side
Dimethylbenzene 0.1ml/ is smeared only to inflammation in two sides inside and outside ear corridor, and left ear is untreated to do self-blank control group.Smear dimethylbenzene
After 30min, each group tested material sample 0.1g/ is uniformly smeared only respectively in two sides inside and outside every group of every animal auris dextra corridor.It gives tested
After object 1h, the dislocation of small white mouse strength vertebra is put to death, and is cut two ear corridors, is washed away auris dextra corridor tested material sample with physiological saline, use dry cotton ball
It cleans, takes two circle auricles in same position chisel with punch, it is swelling value that auris dextra sheet weight, which subtracts left auricle weight,.As a result such as table
Shown in 2.
The anti-inflammatory effect of the anti-inflammatory antiallergy toothpaste paraxylene of the present invention of table 2 cause small white mouse ear corridor acute inflammation swelling
Note: compared with blank control group:*P < 0.05,**P<0.01,***P<0.001,#P > 0.05.
Compared with toothpaste bare substrate group:$P < 0.05,$$P<0.01,$$$P<0.001。
Statistical procedures: total data is for statistical analysis using SPSS19.0 statistics software, measurement data mean
± standard deviation (x ± s) indicates.
From table 2 it can be seen that anti-inflammatory antiallergy toothpaste of the invention can make small white mouse acute inflammation swelling ear corridor quality aobvious
It writes and mitigates, hence it is evident that inhibit small white mouse ear corridor acute inflammation swelling caused by dimethylbenzene, show anti-inflammatory antiallergy toothpaste pair of the invention
Acute inflammation has apparent anti-inflammatory effect.It can be seen that each component of anti-inflammatory antiallergy toothpaste of the present invention is for caused by dimethylbenzene xylene
The anti-inflammatory aspect of small white mouse ear corridor acute inflammation swelling has significant synergistic effect.
3 embodiment of the present invention of test example and comparative example prepare the anti-allergic effects of resulting anti-inflammatory antiallergy toothpaste
Test method: choosing, there is 300 people of oral cavity allergy discomfort subject to test, each half of men and women, and the age is from 18
~59 years old, average age 30 years old.6 groups are randomly divided into, every group of 50 people, respectively using the embodiment of the present invention and comparative example preparation gained
Anti-inflammatory antiallergy toothpaste, every morning, respectively brush teeth at night it is primary.
It brushes teeth before test, the oral cavity allergy for first recording subject is uncomfortable.
After brushing teeth test the 7th day, then the unified oral cavity allergy discomfort variation for examining subject.
Criterion: after test of brushing teeth, it is effectively, conversely, unchanged that subject oral cavity allergy discomfort, which is mitigated or eliminated,
Or oral cavity allergy discomfort adds severe one to be accordingly to be regarded as in vain.
It is examined after subject was using seven days, as a result as follows:
In terms of the inspection result of subject, anti-inflammatory antiallergy toothpaste of the invention, for mitigating oral cavity allergy malaise symptoms
Effective percentage is significantly better than that the statistical data of control group up to 84% or more.Therefore, anti-inflammatory antiallergy toothpaste of the invention, for
Oral cavity allergy discomfort has good prevention and treatment effect.
Above-mentioned experiment shows that anti-inflammatory antiallergy toothpaste of the present invention has good bactericidal effect；It can inhibit mouse ear swelling
Degree；There is good prevention and treatment effect to oral cavity allergy discomfort.For single active ingredient, of the present invention group
Closing object, there is superposition and syneryistic effect, each raw material to complement each other, and plays the synergistic effect between raw material, makes anti-inflammatory of the invention
Reached with anti-allergic effects is most preferably a kind of anti-inflammatory antiallergy toothpaste with health role, application and development with higher
Value.
Claims (6)
1. a kind of anti-inflammatory antiallergy toothpaste, which is characterized in that be made of by weight percentage following components: chitosan oligosaccharide 2~8%,
Pinellia tuber extract 0.6-5%, silver perfume (or spice) extract 0.5-1.2%, the moisturizer of cimicifuga foetida extract 0.4-6%, 20-30%, 40-
50% abrasive, the thickener of 0.6-2%, the surfactant of 1.5-2.5%, the sweetener of 0.1-0.5%, 0.1-
0.5% preservative, the essence of 1-1.5%, deionized water are added to 100%.
2. anti-inflammatory antiallergy toothpaste according to claim 1, which is characterized in that it be by following components by weight percentage
Composition: chitosan oligosaccharide 5%, pinellia tuber extract 2%, silver perfume (or spice) extract 0.9%, cimicifuga foetida extract 3%, 28% moisturizer,
45% abrasive, 1.3% thickener, 2.0% surfactant, 0.3% sweetener, 0.3% preservative,
1.2% essence, deionized water are added to 100%.
3. anti-inflammatory antiallergy toothpaste according to claim 1, it is characterised in that: the preparation method of the pinellia tuber extract
Are as follows:
By Pinellia Ternate dries pulverizing, the water for being equivalent to 6-12 times of weight of the tuber of pinellia is added, is extracted 2 times at 70-90 DEG C, each 2-
3h, discards filter residue after filtering, extracting solution is concentrated under reduced pressure into relative density 1.20-1.30 after merging, its quality is added thereto
The 6-8 times of dehydrated alcohol for measuring volume, stands overnight, and supernatant is taken to be concentrated under reduced pressure into relative density 1.20-1.25, it is dry to get
Pinellia tuber extract
The silver perfume (or spice) extract the preparation method comprises the following steps:
By silver perfume (or spice) bark or root skin dries pulverizing, 70% ethanol water for being equivalent to silver perfume (or spice) 6-12 times of volume of weight is added
It extracting, refluxing extraction 2-3 times at 65-75 DEG C, each extraction time is 1-3h, discard filter residue after filtering, merging filtrate,
Medicinal extract shape is concentrated under reduced pressure into constant weight, drying is to get silver perfume (or spice) extract.
The cimicifuga foetida extract the preparation method comprises the following steps:
By cimicifugae foetidae medicinal material dries pulverizing, 70% ethanol water that 8-14 times of volume of cimicifugae foetidae weight is added is extracted, in 65-75
Refluxing extraction 2-3 times at DEG C, each extraction time are 1-3h, and combined extract is concentrated under reduced pressure at medicinal extract shape to constant weight, thereto
2-3 times of its quality n-hexane extraction for measuring volume is added, removes lipid part, then 2-3 times of its quality is added thereto and measures
The ethyl acetate of volume extracts, and extract liquor is concentrated under reduced pressure into medicinal extract to constant weight, dry to get cimicifuga foetida extract.
4. anti-inflammatory antiallergy toothpaste according to claim 1, it is characterised in that: the moisturizer is sorbierite, glycerol, gathers
One of ethylene glycol, propylene glycol or a variety of mixtures；
The abrasive is one of calcium carbonate, calcium monohydrogen phosphate, silica or a variety of mixtures；
The thickener is one of sodium carboxymethylcellulose, hydroxyethyl cellulose, xanthan gum, guar gum, carragheen or more
Kind mixture；
The surfactant is sldium lauryl sulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl glycine betaine
One of or a variety of mixtures.
The sweetener is one of saccharin sodium, button sweet tea, Sucralose, acesulfame potassium or a variety of mixtures；
The preservative is sodium benzoate, methyl hydroxybenzoate, ethyl hydroxy benzoate, Nipasol, butyl hydroxybenzoate, one in methyl hydroxybenzoate sodium
Kind or a variety of mixtures.
5. anti-inflammatory antiallergy toothpaste according to claim 1, it is characterised in that: the chitosan oligosaccharide molecular weight be 1500Da~
3000Da, the degree of polymerization are 2~20.
6. a kind of preparation method of any one of claim 1-5 anti-inflammatory antiallergy toothpaste, it is characterized in that the following steps are included:
1) rubbing agent, thickener, sweetener and the preservative for weighing formula ratio are dissolved with appropriate amount of deionized water, and mixed liquor A is made
It is spare；
2) by the chitosan oligosaccharide of formula ratio, pinellia tuber extract, silver perfume (or spice) extract, cimicifuga foetida extract, surfactant and moisturizer
Be mixed evenly mixed liquid B is spare；
3) mixed liquid B is added in mixed liquor A, essence is then added, agitation grinding is sufficiently mixed creme uniformly, and vacuum is de-
Gas cream is packed up to the anti-inflammatory antiallergy toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910493202.7A CN110101638A (en) | 2019-06-06 | 2019-06-06 | A kind of anti-inflammatory antiallergy toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910493202.7A CN110101638A (en) | 2019-06-06 | 2019-06-06 | A kind of anti-inflammatory antiallergy toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110101638A true CN110101638A (en) | 2019-08-09 |
Family
ID=67494261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910493202.7A Withdrawn CN110101638A (en) | 2019-06-06 | 2019-06-06 | A kind of anti-inflammatory antiallergy toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110101638A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638910A (en) * | 2019-08-26 | 2020-01-03 | 白银香生物科技有限公司 | A breath freshener with antiviral, antibacterial and antiinflammatory effects, and its preparation method |
| CN110946778A (en) * | 2019-12-19 | 2020-04-03 | 华熙生物科技股份有限公司 | Toothpaste with anti-inflammation and bacteriostasis functions |
| CN111249289A (en) * | 2020-02-14 | 2020-06-09 | 广西英路维特药物有限公司 | Oral care product or medicament for anti-inflammation and/or anti-allergy |
| CN111358724A (en) * | 2020-04-20 | 2020-07-03 | 平措绕吉 | Functional toothpaste and preparation method thereof |
| CN111888304A (en) * | 2020-09-16 | 2020-11-06 | 白银香生物科技有限公司 | Anti-inflammation and anti-allergy toothpaste and preparation method thereof |
| CN113425653A (en) * | 2021-08-11 | 2021-09-24 | 赵新辉 | Preparation process of antiallergic toothpaste |
-
2019
- 2019-06-06 CN CN201910493202.7A patent/CN110101638A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638910A (en) * | 2019-08-26 | 2020-01-03 | 白银香生物科技有限公司 | A breath freshener with antiviral, antibacterial and antiinflammatory effects, and its preparation method |
| CN110946778A (en) * | 2019-12-19 | 2020-04-03 | 华熙生物科技股份有限公司 | Toothpaste with anti-inflammation and bacteriostasis functions |
| CN111249289A (en) * | 2020-02-14 | 2020-06-09 | 广西英路维特药物有限公司 | Oral care product or medicament for anti-inflammation and/or anti-allergy |
| CN111358724A (en) * | 2020-04-20 | 2020-07-03 | 平措绕吉 | Functional toothpaste and preparation method thereof |
| CN111888304A (en) * | 2020-09-16 | 2020-11-06 | 白银香生物科技有限公司 | Anti-inflammation and anti-allergy toothpaste and preparation method thereof |
| CN111888304B (en) * | 2020-09-16 | 2021-01-26 | 白银香生物科技有限公司 | Anti-inflammation and anti-allergy toothpaste and preparation method thereof |
| CN113425653A (en) * | 2021-08-11 | 2021-09-24 | 赵新辉 | Preparation process of antiallergic toothpaste |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110101638A (en) | A kind of anti-inflammatory antiallergy toothpaste | |
| CN106265423B (en) | Oral care composition with effects of clearing fire and relieving pain | |
| KR101481371B1 (en) | Toothpaste composition containing Curcuma longa L and production method thereof | |
| TW200812637A (en) | Vegetable composition for cleaning oral cavity | |
| US20120288454A1 (en) | Dental protection toothpaste composition | |
| CN106924106A (en) | A kind of toothpaste for suppressing bacterial plaque and mitigate gingivitis | |
| CN109276475A (en) | One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof | |
| CN104042780A (en) | Oral cavity care solution | |
| CN110787078A (en) | Toothpaste containing licoflavone and preparation method and application thereof | |
| CN102552082A (en) | Toothpaste containing Phyllanthus emblica extracts | |
| CN110507572B (en) | Antibacterial and deodorant toothpaste and preparation method thereof | |
| KR101881636B1 (en) | Composition for prevention or treatment of oral disease comprising Pueraria Extract | |
| CN107375168A (en) | A kind of anti-caries toothpaste of American-cockroach-extract-containing | |
| CN106974866A (en) | A kind of folium artemisiae argyi formula toothpaste and preparation method thereof | |
| CN115212128A (en) | Anti-inflammation mouth wash containing chlorogenic acid and preparation method thereof | |
| CN104224981A (en) | Traditional Chinese medicine composition for improving gum and periodontal health and toothpaste containing same | |
| CN106539727A (en) | Sterilization tooth-caring toothpaste | |
| CN106333891A (en) | Anti-inflammation and pain-alleviating toothpaste and preparation method thereof | |
| KR20150040818A (en) | Oral Hygiene functional composition and a method of manufacturing | |
| CN110200824A (en) | A kind of sugar-free toothpaste and its production method containing resveratrol | |
| CN109953921A (en) | A kind of capable of clearing heat and reducing internal heat toothpaste and preparation method thereof | |
| KR20180054533A (en) | Raspberry leaf fermentation, nasal cavity, oral, throat, skin, cleansing(gargle) beverages, The compositions of the manufacturing process | |
| CN109044898A (en) | A kind of hemostasis oral cavity nursing agent of brilliant white fresh breath type | |
| CN113288833B (en) | A toothpaste containing extract of marrubium vulgare for relieving sensitivity | |
| KR101456655B1 (en) | Preventing and Treating Composition for dandruff and itchy scalp |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190809 |