CN103417397B - Hydroxyapatite type toothpaste - Google Patents
Hydroxyapatite type toothpaste Download PDFInfo
- Publication number
- CN103417397B CN103417397B CN201310351975.4A CN201310351975A CN103417397B CN 103417397 B CN103417397 B CN 103417397B CN 201310351975 A CN201310351975 A CN 201310351975A CN 103417397 B CN103417397 B CN 103417397B
- Authority
- CN
- China
- Prior art keywords
- extract
- water
- hydroxyapatite
- toothpaste
- type toothpaste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 33
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 33
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 32
- 239000000606 toothpaste Substances 0.000 title claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 51
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 19
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 11
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 10
- 239000011734 sodium Substances 0.000 claims abstract description 10
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 10
- 239000000661 sodium alginate Substances 0.000 claims abstract description 10
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 10
- 229940013618 stevioside Drugs 0.000 claims abstract description 10
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000019202 steviosides Nutrition 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 20
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 15
- 241000205585 Aquilegia canadensis Species 0.000 claims description 13
- 229930192961 schisandrol Natural products 0.000 claims description 13
- 206010018286 Gingival pain Diseases 0.000 abstract description 8
- 206010018291 Gingival swelling Diseases 0.000 abstract description 8
- 208000024891 symptom Diseases 0.000 abstract description 7
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 6
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 6
- 210000000214 mouth Anatomy 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 2
- 239000008367 deionised water Substances 0.000 description 16
- 229910021641 deionized water Inorganic materials 0.000 description 16
- 229960000935 dehydrated alcohol Drugs 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000001556 precipitation Methods 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 241000628997 Flos Species 0.000 description 7
- 206010018276 Gingival bleeding Diseases 0.000 description 6
- 208000024283 Gingival haemorrhages Diseases 0.000 description 6
- 208000025865 Ulcer Diseases 0.000 description 6
- 231100000397 ulcer Toxicity 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 238000009835 boiling Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 230000000680 avirulence Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 30-40% hydroxyapatite, 20-40%1,2-propylene glycol, 2.5-3.5% sodium lauroamphopg-acetate phosphate, 1-3% sodium alginate, 1-3% stevioside, surplus are water.Toothpaste of the present invention effectively suppressing oral cavity bacterium, take care of one's teeth, while fresh breath, be also applicable to oral ulcer patient, alleviate the symptoms such as gingival swelling and pain.
Description
Technical field
The present invention relates to a kind of toothpaste, be specifically related to a kind of hydroxyapatite type toothpaste.
Background technology
Toothpaste is used from cleaning teeth with toothbrush one, and protection oral hygiene, to a kind of daily necessities of human-body safety.Along with the raising of people's living standard, the quality requirement of toothpaste is also progressively improved.At aspect of performance General Requirements toothpaste: (1) can remove the thin film of dental surface and bacterial plaque and not damage enamel and dentin; (2) there is good cleaning oral cavity and effect around thereof; (3) avirulence, non-stimulated to oral mucosa; (4) there are comfortable fragrance and taste, after using, have cool and sweet-smelling sensation.
But toothpaste current is not on the market suitable for oral ulcer patient, part oral ulcer conditions of patients even can be made to increase the weight of.
Summary of the invention
For above shortcomings in prior art, technical problem to be solved by this invention is to provide a kind of hydroxyapatite type toothpaste.
The present invention seeks to be achieved through the following technical solutions:
A kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 30-40% hydroxyapatite, 20-40%1,2-propylene glycol, 2.5-3.5% sodium lauroamphopg-acetate phosphate, 1-3% sodium alginate, 1-3% stevioside, surplus are water.
Preferably,
A kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 30-40% hydroxyapatite, 20-40%1,2-propylene glycol, 2.5-3.5% sodium lauroamphopg-acetate phosphate, 1-3% sodium alginate, 1-3% stevioside, 1-3% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 10-30 part, Radix Paeoniae Alba water extract 10-30 part, Poria alcohol extract 5-15 part, schisandrol extract 5-15 part.
In the present invention,
Hydroxyapatite, No. CAS: 1306-06-5; 1,2-PD, No. CAS: 57-55-6; Sodium lauroamphopg-acetate phosphate, No. CAS: 193888-44-7; Sodium alginate, No. CAS: 9005-38-3; Stevioside, No. CAS: 57817-89-7.
Flos Lonicerae, phonetic name: Jinyinhua, English name: FLOSLONICERAEJAPONICAE, page number: Pharmacopoeia of People's Republic of China (version in 2005) 152-153 page.The Radix Paeoniae Alba, phonetic name: Baishao, English name: RADIXPAEONIAEALBA, page number: Pharmacopoeia of People's Republic of China (version in 2005) 68-69 page.Poria, phonetic name: Fuling, English name: PORIA, page number: Pharmacopoeia of People's Republic of China (version in 2005) 166 pages.Fructus Schisandrae Chinensis, phonetic name: Wuweizi, English name: FRUCTUSSCHISANDRAECHINENSIS, page number: Pharmacopoeia of People's Republic of China (version in 2005) 44-45 page.
Honeysuckle flower water extract, Radix Paeoniae Alba water extract, Poria alcohol extract and schisandrol extract are the general raw material of this area, all obtain by self-control or purchase.
A kind of Homemade method of honeysuckle flower water extract can be: after Flos Lonicerae is pulverized, add deionized water, the ratio of Flos Lonicerae and deionized water is 1:5-1:20(g:ml), soak 6-24 hour, heated and boiled 1-3 hour, isolate medicinal liquid, in medicinal residues, add deionized water, the ratio of Flos Lonicerae and deionized water is 1:5-1:20(g:ml), heated and boiled 1-3 hour, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry or lyophilizing, obtained honeysuckle flower water extract.
A kind of Homemade method of Radix Paeoniae Alba water extract can be: after the Radix Paeoniae Alba is pulverized, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1:5-1:20(g:ml), soak 6-24 hour, heated and boiled 1-3 hour, isolate medicinal liquid, in medicinal residues, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1:5-1:20(g:ml), heated and boiled 1-3 hour, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry or lyophilizing, obtained Radix Paeoniae Alba water extract.
A kind of Homemade method of Poria alcohol extract can be: after Poria is pulverized, add dehydrated alcohol, the ratio of Poria and dehydrated alcohol is 1:5-1:20(g:ml), soak 6-24 hour, water-bath backflow 1-3 hour, filter, after centrifugal, discard precipitation, by supernatant concentration, dry or lyophilizing, obtained Poria alcohol extract.
A kind of Homemade method of schisandrol extract can be: after Fructus Schisandrae Chinensis is pulverized, add dehydrated alcohol, the ratio of Fructus Schisandrae Chinensis and dehydrated alcohol is 1:5-1:20(g:ml), soak 6-24 hour, water-bath backflow 1-3 hour, filter, after centrifugal, discard precipitation, by supernatant concentration, dry or lyophilizing, obtained schisandrol extract.
Compared with prior art, hydroxyapatite type toothpaste of the present invention effectively suppressing oral cavity bacterium, take care of one's teeth, while fresh breath, be also applicable to oral ulcer patient, alleviate the symptoms such as gingival swelling and pain.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Honeysuckle flower water extract: after Flos Lonicerae is pulverized, add deionized water, the ratio of Flos Lonicerae and deionized water is 1:10(g:ml), soak 8 hours, heated and boiled 1.5 hours, isolates medicinal liquid, in medicinal residues, add deionized water, the ratio of Flos Lonicerae and deionized water is 1:10(g:ml), heated and boiled 1.5 hours, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry, obtained honeysuckle flower water extract.
Radix Paeoniae Alba water extract: after the Radix Paeoniae Alba is pulverized, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1:10(g:ml), soak 8 hours, heated and boiled 2 hours, isolates medicinal liquid, in medicinal residues, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1:10(g:ml), heated and boiled 1.5 hours, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry, obtained Radix Paeoniae Alba water extract.
Poria alcohol extract: after Poria is pulverized, add dehydrated alcohol, the ratio of Poria and dehydrated alcohol is 1:10(g:ml), soak 12 hours, water-bath refluxes 2 hours, filters, after centrifugal, discards precipitation, by supernatant concentration, dries, obtained Poria alcohol extract.
Schisandrol extract: after Fructus Schisandrae Chinensis is pulverized, add dehydrated alcohol, the ratio of Fructus Schisandrae Chinensis and dehydrated alcohol is 1:10(g:ml), soak 12 hours, water-bath refluxes 2 hours, filters, after centrifugal, discards precipitation, by supernatant concentration, dry, obtained schisandrol extract.
Embodiment 1
A kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 35% hydroxyapatite, 35%1,2-propylene glycol, 3% sodium lauroamphopg-acetate phosphate, 2% sodium alginate, 2% stevioside, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Radix Paeoniae Alba water extract 20 parts, Poria alcohol extract 10 parts, schisandrol extract 10 parts.Honeysuckle flower water extract, Radix Paeoniae Alba water extract, Poria alcohol extract and schisandrol extract are simply mixed both described Chinese medicinal material extract.
Hydroxyapatite type toothpaste of the present invention can adopt the conventional method of this area to prepare completely.Concrete, the preparation method of the present embodiment hydroxyapatite type toothpaste is: after above-mentioned raw materials component being weighed, disperse in pre-dispersed still, mix, open cream still vacuum pump processed and suck above-mentioned liquid material, then open scraper, agitator and colloid mill, after 50 minutes, close colloid mill, agitator and scraper successively, vacuum breaker, obtains hydroxyapatite type toothpaste.
Embodiment 2
A kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 35% hydroxyapatite, 35%1,2-propylene glycol, 3% sodium lauroamphopg-acetate phosphate, 2% sodium alginate, 2% stevioside, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: Radix Paeoniae Alba water extract 20 parts, Poria alcohol extract 10 parts, schisandrol extract 10 parts.
According to the preparation method of embodiment 1, obtain the hydroxyapatite type toothpaste of embodiment 2.
Embodiment 3
A kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 35% hydroxyapatite, 35%1,2-propylene glycol, 3% sodium lauroamphopg-acetate phosphate, 2% sodium alginate, 2% stevioside, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Poria alcohol extract 10 parts, schisandrol extract 10 parts.
According to the preparation method of embodiment 1, obtain the hydroxyapatite type toothpaste of embodiment 3.
Embodiment 4
A kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 35% hydroxyapatite, 35%1,2-propylene glycol, 3% sodium lauroamphopg-acetate phosphate, 2% sodium alginate, 2% stevioside, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Radix Paeoniae Alba water extract 20 parts, schisandrol extract 10 parts.
According to the preparation method of embodiment 1, obtain the hydroxyapatite type toothpaste of embodiment 4.
Embodiment 5
A kind of hydroxyapatite type toothpaste, be made up of following compositions in weight percentage: 35% hydroxyapatite, 35%1,2-propylene glycol, 3% sodium lauroamphopg-acetate phosphate, 2% sodium alginate, 2% stevioside, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Radix Paeoniae Alba water extract 20 parts, Poria alcohol extract 10 parts.
According to the preparation method of embodiment 1, obtain the hydroxyapatite type toothpaste of embodiment 5.
Test case
Clinical oral test is carried out to the toothpaste of embodiment 1-5, suffers from the patient of recurrent exerbation oral ulcer for 100 altogether, be all attended by the symptom of gingival swelling and pain and gingival hemorrhage.100 patients are divided into 5 groups at random, often organize 20 people, use every day the toothpaste of embodiment 1-5 to brush teeth 2 times, each 5 minutes, adhere to 3 months, result is as following table 1.
The standard of curative effect evaluation: change highly significant is that total ulcer number obviously reduces, gingival swelling and pain and gingival hemorrhage transference cure; Change as total ulcer decreased number, the symptom such as gingival swelling and pain and gingival hemorrhage alleviates or the cycle stretch-out that shows effect; Change significantly for total ulcer number without significant change or the symptom such as gingival swelling and pain and gingival hemorrhage without obviously alleviating; Unchanged is that total ulcer number is unchanged, and the symptom such as gingival swelling and pain and gingival hemorrhage is without alleviating.
Table 1 embodiment 1-5 hydroxyapatite type toothpaste is to the effect (number) of oral cavity ulcers
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
| Unchanged | 0 | 1 | 2 | 2 | 2 |
| Change not remarkable | 2 | 4 | 3 | 3 | 2 |
| Change | 7 | 5 | 5 | 4 | 6 |
| Change highly significant | 11 | 9 | 10 | 10 | 9 |
| Effective percentage | 90% | 70% | 75% | 70% | 75% |
| Obvious effective rate | 55% | 45% | 50% | 50% | 45% |
Effective percentage=(number of changing+change highly significant number) ÷ always tests number × 100%
Obvious effective rate=change highly significant number ÷ always tests number × 100%
Inventor is found by lot of experiments, after honeysuckle flower water extract, Radix Paeoniae Alba water extract, Poria alcohol extract, schisandrol extract is composite, remarkable to suffering from more serious oral ulcer patient outcome, the gingival swelling and pain of patient and the symptom of gingival hemorrhage also have to be eliminated or slows down.Hydroxyapatite type toothpaste of the present invention solves current a lot of toothpaste to the problem of the irritant effect of oral cavity ulcers.
Claims (1)
1. a hydroxyapatite type toothpaste, it is characterized in that, be made up of following compositions in weight percentage: 30-40% hydroxyapatite, 20-40%1,2-propylene glycol, 2.5-3.5% sodium lauroamphopg-acetate phosphate, 1-3% sodium alginate, 1-3% stevioside, 1-3% Chinese medicinal material extract, surplus are water;
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 10-30 part, Radix Paeoniae Alba water extract 10-30 part, Poria alcohol extract 5-15 part, schisandrol extract 5-15 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310351975.4A CN103417397B (en) | 2013-08-13 | 2013-08-13 | Hydroxyapatite type toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310351975.4A CN103417397B (en) | 2013-08-13 | 2013-08-13 | Hydroxyapatite type toothpaste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103417397A CN103417397A (en) | 2013-12-04 |
| CN103417397B true CN103417397B (en) | 2016-02-17 |
Family
ID=49643144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310351975.4A Expired - Fee Related CN103417397B (en) | 2013-08-13 | 2013-08-13 | Hydroxyapatite type toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103417397B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6351929B2 (en) * | 2013-03-21 | 2018-07-04 | 株式会社ロッテ | Oral composition for reducing hypersensitivity |
| CN111773166A (en) * | 2020-08-10 | 2020-10-16 | 浙江埃普瑞纳米材料有限公司 | Hydroxyapatite type toothpaste |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179305A (en) * | 1996-10-13 | 1998-04-22 | 贺志弘 | Ginkgo toothpaste |
| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
| CN1429538A (en) * | 2002-01-01 | 2003-07-16 | 孟祥才 | Nano-grade hydroxy apatite, its preparation method and application in toothpaste |
| CN102961303A (en) * | 2012-11-22 | 2013-03-13 | 侯和平 | Toothpaste capable of strongly decontaminating |
-
2013
- 2013-08-13 CN CN201310351975.4A patent/CN103417397B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179305A (en) * | 1996-10-13 | 1998-04-22 | 贺志弘 | Ginkgo toothpaste |
| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
| CN1429538A (en) * | 2002-01-01 | 2003-07-16 | 孟祥才 | Nano-grade hydroxy apatite, its preparation method and application in toothpaste |
| CN102961303A (en) * | 2012-11-22 | 2013-03-13 | 侯和平 | Toothpaste capable of strongly decontaminating |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103417397A (en) | 2013-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110812316B (en) | Toothpaste containing various traditional Chinese medicine compositions, preparation method and application thereof | |
| CN106924106B (en) | Toothpaste for inhibiting dental plaque and relieving gingival inflammation | |
| CN105055230A (en) | Multifunctional Chinese medicinal toothpaste composition, toothpaste prepared from composition and preparation method of toothpaste | |
| CN103520049B (en) | Compound Chinese medicine extract is preparing the application in oral cavity nursing health products | |
| CN102138887A (en) | Multifunctional compound golden thread Chinese medicinal herb toothpaste | |
| CN103784933A (en) | Recurrent oral ulcer power | |
| CN103445977B (en) | Calcium carbonate type toothpaste | |
| CN106511185A (en) | Toothpaste for preventing and treating gingival bleeding and preparation method thereof | |
| CN105411959A (en) | Healthcare toothpaste containing traditional Chinese herbals and preparation method thereof | |
| CN106377481B (en) | A method for extracting rhizoma Cyperi extract, and toothpaste and collutory containing the same | |
| CN103417397B (en) | Hydroxyapatite type toothpaste | |
| CN103417396B (en) | Calcite-type toothpaste | |
| CN103446008B (en) | Magnesium carbonate type toothpaste | |
| CN103432018B (en) | Aluminum oxide type toothpaste | |
| CN103445978B (en) | Calcium hydrogen phosphate type toothpaste | |
| CN103417398B (en) | Calcium pyrophosphate toothpaste | |
| CN104258092B (en) | A kind of gargle for treating RAU and periodontosis and preparation method thereof | |
| CN103445976B (en) | Silicon dioxide type toothpaste | |
| CN104224981A (en) | Traditional Chinese medicine composition for improving gum and periodontal health and toothpaste containing same | |
| CN108295023B (en) | Traditional Chinese medicine toothpaste and preparation method thereof | |
| CN103462819B (en) | Be applicable to the toothpaste of oral ulcer patient | |
| Mahant et al. | Home remedies for dental diseases in the Pandemic of COVID-19-A Systematic Review | |
| KR20170090717A (en) | Mouthwash | |
| BORCHERS et al. | Traditional Asian medicine and oral health | |
| CN104323959A (en) | Charred traditional Chinese medicine composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180328 Address after: 515100, Guangdong, Shantou Province, Sima, Hong Kong, Hong Kong, Hong Kong, Hulu Industrial Zone, four street, a building Patentee after: GUANGDONG SANJIAO DAILYCHEMICAL Co.,Ltd. Address before: 201107 Shanghai city Minhang District Minhang Road 88 Lane No. 1-30 building twenty-second room T159 Patentee before: SHANGHAI FANGMU FINE CHEMICAL Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160217 |