CN103462819B - Be applicable to the toothpaste of oral ulcer patient - Google Patents
Be applicable to the toothpaste of oral ulcer patient Download PDFInfo
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- CN103462819B CN103462819B CN201310356279.2A CN201310356279A CN103462819B CN 103462819 B CN103462819 B CN 103462819B CN 201310356279 A CN201310356279 A CN 201310356279A CN 103462819 B CN103462819 B CN 103462819B
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Abstract
The present invention relates to a kind of toothpaste being applicable to oral ulcer patient, be made up of following compositions in weight percentage: 32-38% calcium carbonate, 28-42% sorbitol, 2-4% octyl group-beta-D-pyranglucoside, 1-3% hydroxyethyl-cellulose, 1-3% xylitol, surplus are water.Toothpaste of the present invention effectively suppressing oral cavity bacterium, take care of one's teeth, while fresh breath, be also applicable to oral ulcer patient, alleviate the symptoms such as gingival swelling and pain.
Description
Technical field
The present invention relates to a kind of toothpaste, be specifically related to a kind of toothpaste being applicable to oral ulcer patient.
Background technology
Toothpaste is used from cleaning teeth with toothbrush one, and protection oral hygiene, to a kind of daily necessities of human-body safety.Along with the raising of people's living standard, the quality requirement of toothpaste is also progressively improved.At aspect of performance General Requirements toothpaste: (1) can remove the thin film of dental surface and bacterial plaque and not damage enamel and dentin; (2) there is good cleaning oral cavity and effect around thereof; (3) avirulence, non-stimulated to oral mucosa; (4) there are comfortable fragrance and taste, after using, have cool and sweet-smelling sensation.
Oral ulcer, is among the peoplely generally referred to as " getting angry in oral cavity " or " aphtha ", and the oral mucosa limitation ulcerative lesions of feature that to be a kind of with periodic flare be, can occur in any position of oral mucosa.Common with the mucosa at the places such as the lip in oral cavity, cheek, soft palate or gums, there is single or multiple circle of differing in size or oval ulcer, greyish white or the yellow pseudomembrane of surface coverage, concavity, clear border, surrounding mucosa is red and micro-swollen, and ulcer local causalgia is obvious, has the feature of periodicity, recurrent, self limiting.Serious oral ulcer patient also may with the complication such as gingival swelling and pain, gingival hemorrhage.
But toothpaste current is not on the market suitable for oral ulcer patient, part oral ulcer conditions of patients even can be made to increase the weight of.
Summary of the invention
For above shortcomings in prior art, technical problem to be solved by this invention is to provide a kind of toothpaste being applicable to oral ulcer patient.
The present invention seeks to be achieved through the following technical solutions:
Be applicable to an oral ulcer patient's toothpaste, be made up of following compositions in weight percentage: 32-38% calcium carbonate, 28-42% sorbitol, 2-4% octyl group-beta-D-pyranglucoside, 1-3% hydroxyethyl-cellulose, 1-3% xylitol, surplus are water.
Preferably,
Be applicable to an oral ulcer patient's toothpaste, be made up of following compositions in weight percentage: 32-38% calcium carbonate, 28-42% sorbitol, 2-4% octyl group-beta-D-pyranglucoside, 1-3% hydroxyethyl-cellulose, 1-3% xylitol, 1-3% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 10-30 part, Radix Paeoniae Alba water extract 10-30 part, Poria alcohol extract 5-15 part, schisandrol extract 5-15 part.
In the present invention,
Calcium carbonate, No. CAS: 471-34-1; Sorbitol, No. CAS: 50-70-4; Octyl group-beta-D-pyranglucoside, No. CAS: 29836-26-8; Hydroxyethyl-cellulose, No. CAS: 9004-62-0; Xylitol, No. CAS: 87-99-0.
Flos Lonicerae, phonetic name: Jinyinhua, English name: FLOSLONICERAEJAPONICAE, page number: Pharmacopoeia of People's Republic of China (version in 2005) 152-153 page.The Radix Paeoniae Alba, phonetic name: Baishao, English name: RADIXPAEONIAEALBA, page number: Pharmacopoeia of People's Republic of China (version in 2005) 68-69 page.Poria, phonetic name: Fuling, English name: PORIA, page number: Pharmacopoeia of People's Republic of China (version in 2005) 166 pages.Fructus Schisandrae Chinensis, phonetic name: Wuweizi, English name: FRUCTUSSCHISANDRAECHINENSIS, page number: Pharmacopoeia of People's Republic of China (version in 2005) 44-45 page.
Honeysuckle flower water extract, Radix Paeoniae Alba water extract, Poria alcohol extract and schisandrol extract are the general raw material of this area, all obtain by self-control or purchase.
A kind of Homemade method of honeysuckle flower water extract can be: after Flos Lonicerae is pulverized, add deionized water, the ratio of Flos Lonicerae and deionized water is 1: 5-1: 20(g: ml), soak 6-24 hour, heated and boiled 1-3 hour, isolate medicinal liquid, in medicinal residues, add deionized water, the ratio of Flos Lonicerae and deionized water is 1: 5-1: 20(g: ml), heated and boiled 1-3 hour, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry or lyophilizing, obtained honeysuckle flower water extract.
A kind of Homemade method of Radix Paeoniae Alba water extract can be: after the Radix Paeoniae Alba is pulverized, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1: 5-1: 20(g: ml), soak 6-24 hour, heated and boiled 1-3 hour, isolate medicinal liquid, in medicinal residues, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1: 5-1: 20(g: ml), heated and boiled 1-3 hour, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry or lyophilizing, obtained Radix Paeoniae Alba water extract.
A kind of Homemade method of Poria alcohol extract can be: after Poria is pulverized, add dehydrated alcohol, the ratio of Poria and dehydrated alcohol is 1: 5-1: 20(g: ml), soak 6-24 hour, water-bath backflow 1-3 hour, filter, after centrifugal, discard precipitation, by supernatant concentration, dry or lyophilizing, obtained Poria alcohol extract.
A kind of Homemade method of schisandrol extract can be: after Fructus Schisandrae Chinensis is pulverized, add dehydrated alcohol, the ratio of Fructus Schisandrae Chinensis and dehydrated alcohol is 1: 5-1: 20(g: ml), soak 6-24 hour, water-bath backflow 1-3 hour, filter, after centrifugal, discard precipitation, by supernatant concentration, dry or lyophilizing, obtained schisandrol extract.
Compared with prior art, the toothpaste being applicable to oral ulcer patient of the present invention effectively suppressing oral cavity bacterium, take care of one's teeth, while fresh breath, be also applicable to oral ulcer patient, alleviate the symptoms such as gingival swelling and pain.Obviously, the ordinary consumer not suffering from oral ulcer also can life-time service toothpaste of the present invention, fresh breath.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Honeysuckle flower water extract: after Flos Lonicerae is pulverized, add deionized water, the ratio of Flos Lonicerae and deionized water is 1: 10(g: ml), soak 8 hours, heated and boiled 1.5 hours, isolates medicinal liquid, in medicinal residues, add deionized water, the ratio of Flos Lonicerae and deionized water is 1: 10(g: ml), heated and boiled 1.5 hours, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry, obtained honeysuckle flower water extract.
Radix Paeoniae Alba water extract: after the Radix Paeoniae Alba is pulverized, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1: 10(g: ml), soak 8 hours, heated and boiled 2 hours, isolates medicinal liquid, in medicinal residues, add deionized water, the ratio of the Radix Paeoniae Alba and deionized water is 1: 10(g: ml), heated and boiled 1.5 hours, medicinal liquid after boiling twice merges, filter, after centrifugal, discard precipitation by supernatant concentration, dry, obtained Radix Paeoniae Alba water extract.
Poria alcohol extract: after Poria is pulverized, add dehydrated alcohol, the ratio of Poria and dehydrated alcohol is 1: 10(g: ml), soak 12 hours, water-bath refluxes 2 hours, filters, after centrifugal, discards precipitation, by supernatant concentration, dries, obtained Poria alcohol extract.
Schisandrol extract: after Fructus Schisandrae Chinensis is pulverized, add dehydrated alcohol, the ratio of Fructus Schisandrae Chinensis and dehydrated alcohol is 1: 10(g: ml), soak 12 hours, water-bath refluxes 2 hours, filters, after centrifugal, discards precipitation, by supernatant concentration, dry, obtained schisandrol extract.
Embodiment 1
Be applicable to an oral ulcer patient's toothpaste, be made up of following compositions in weight percentage: 35% calcium carbonate, 35% sorbitol, 3% octyl group-beta-D-pyranglucoside, 2% hydroxyethyl-cellulose, 2% xylitol, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Radix Paeoniae Alba water extract 20 parts, Poria alcohol extract 10 parts, schisandrol extract 10 parts.Honeysuckle flower water extract, Radix Paeoniae Alba water extract, Poria alcohol extract and schisandrol extract are simply mixed both described Chinese medicinal material extract.
The toothpaste that the present invention is applicable to oral ulcer patient can adopt the conventional method of this area to prepare completely.Concrete, the preparation method that the present embodiment is applicable to the toothpaste of oral ulcer patient is: after above-mentioned raw materials component being weighed, disperse in pre-dispersed still, mix, open cream still vacuum pump processed and suck above-mentioned liquid material, then open scraper, agitator and colloid mill, after 50 minutes, close colloid mill, agitator and scraper successively, vacuum breaker, obtains the toothpaste being applicable to oral ulcer patient.
Embodiment 2
Be applicable to an oral ulcer patient's toothpaste, be made up of following compositions in weight percentage: 35% calcium carbonate, 35% sorbitol, 3% octyl group-beta-D-pyranglucoside, 2% hydroxyethyl-cellulose, 2% xylitol, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: Radix Paeoniae Alba water extract 20 parts, Poria alcohol extract 10 parts, schisandrol extract 10 parts.
According to the preparation method of embodiment 1, obtain the toothpaste being applicable to oral ulcer patient of embodiment 2.
Embodiment 3
Be applicable to an oral ulcer patient's toothpaste, be made up of following compositions in weight percentage: 35% calcium carbonate, 35% sorbitol, 3% octyl group-beta-D-pyranglucoside, 2% hydroxyethyl-cellulose, 2% xylitol, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Poria alcohol extract 10 parts, schisandrol extract 10 parts.
According to the preparation method of embodiment 1, obtain the toothpaste being applicable to oral ulcer patient of embodiment 3.
Embodiment 4
Be applicable to an oral ulcer patient's toothpaste, be made up of following compositions in weight percentage: 35% calcium carbonate, 35% sorbitol, 3% octyl group-beta-D-pyranglucoside, 2% hydroxyethyl-cellulose, 2% xylitol, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Radix Paeoniae Alba water extract 20 parts, schisandrol extract 10 parts.
According to the preparation method of embodiment 1, obtain the toothpaste being applicable to oral ulcer patient of embodiment 4.
Embodiment 5
Be applicable to an oral ulcer patient's toothpaste, be made up of following compositions in weight percentage: 35% calcium carbonate, 35% sorbitol, 3% octyl group-beta-D-pyranglucoside, 2% hydroxyethyl-cellulose, 2% xylitol, 2% Chinese medicinal material extract, surplus are water.
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 20 parts, Radix Paeoniae Alba water extract 20 parts, Poria alcohol extract 10 parts.
According to the preparation method of embodiment 1, obtain the toothpaste being applicable to oral ulcer patient of embodiment 5.
Test case
Clinical oral test is carried out to the toothpaste of embodiment 1-5, suffers from the patient of recurrent exerbation oral ulcer for 100 altogether, be all attended by the symptom of gingival swelling and pain and gingival hemorrhage.100 patients are divided into 5 groups at random, often organize 20 people, use every day the toothpaste of embodiment 1-5 to brush teeth 2 times, each 5 minutes, adhere to 3 months, result is as following table 1.
The standard of curative effect evaluation: change highly significant is that total ulcer number obviously reduces, gingival swelling and pain and gingival hemorrhage transference cure; Change as total ulcer decreased number, the symptom such as gingival swelling and pain and gingival hemorrhage alleviates or the cycle stretch-out that shows effect; Change significantly for total ulcer number without significant change or the symptom such as gingival swelling and pain and gingival hemorrhage without obviously alleviating; Unchanged is that total ulcer number is unchanged, and the symptom such as gingival swelling and pain and gingival hemorrhage is without alleviating.
Table 1 embodiment 1-5 is applicable to the effect (number) of toothpaste to oral cavity ulcers of oral ulcer patient
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
| Unchanged | 0 | 1 | 1 | 1 | 1 |
| Change not remarkable | 1 | 3 | 4 | 5 | 3 |
| Change | 6 | 6 | 4 | 2 | 5 |
| Change highly significant | 13 | 10 | 11 | 12 | 11 |
| Effective percentage | 95% | 80% | 75% | 70% | 80% |
| Obvious effective rate | 65% | 50% | 55% | 60% | 55% |
Effective percentage=(number of changing+change highly significant number) ÷ always tests number × 100%
Obvious effective rate=change highly significant number ÷ always tests number × 100%
Inventor is found by lot of experiments, after honeysuckle flower water extract, Radix Paeoniae Alba water extract, Poria alcohol extract, schisandrol extract is composite, remarkable to suffering from more serious oral ulcer patient outcome, the gingival swelling and pain of patient and the symptom of gingival hemorrhage also have to be eliminated or slows down.The toothpaste being applicable to oral ulcer patient of the present invention solves current a lot of toothpaste to the problem of the irritant effect of oral cavity ulcers.
Claims (1)
1. one kind is applicable to the toothpaste of oral ulcer patient, it is characterized in that, be made up of following compositions in weight percentage: 32-38% calcium carbonate, 28-42% sorbitol, 2-4% octyl group-beta-D-pyranglucoside, 1-3% hydroxyethyl-cellulose, 1-3% xylitol, 1-3% Chinese medicinal material extract, surplus are water;
Described Chinese medicinal material extract is made up of by weight following component: honeysuckle flower water extract 10-30 part, Radix Paeoniae Alba water extract 10-30 part, Poria alcohol extract 5-15 part, schisandrol extract 5-15 part.
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| CN201310356279.2A CN103462819B (en) | 2013-08-13 | 2013-08-13 | Be applicable to the toothpaste of oral ulcer patient |
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| CN201310356279.2A CN103462819B (en) | 2013-08-13 | 2013-08-13 | Be applicable to the toothpaste of oral ulcer patient |
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| CN103462819B true CN103462819B (en) | 2016-03-16 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181548A (en) * | 2007-12-07 | 2008-05-21 | 北京未名宝生物科技有限公司 | Medicinal or health care composition containing natural antimicrobials |
| CN101474141A (en) * | 2008-12-04 | 2009-07-08 | 崔翔 | Method for producing nano Chinese medicinal toothpaste |
| CN101797214A (en) * | 2010-04-16 | 2010-08-11 | 祝根华 | Quick-acting toothpaste for preventing and curing mouth diseases and periodontitis and production process thereof |
| CN101897658A (en) * | 2010-07-02 | 2010-12-01 | 中国科学院广州生物医药与健康研究院 | Mouth rinse for removing halitosis and preparation method thereof |
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2013
- 2013-08-13 CN CN201310356279.2A patent/CN103462819B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181548A (en) * | 2007-12-07 | 2008-05-21 | 北京未名宝生物科技有限公司 | Medicinal or health care composition containing natural antimicrobials |
| CN101474141A (en) * | 2008-12-04 | 2009-07-08 | 崔翔 | Method for producing nano Chinese medicinal toothpaste |
| CN101797214A (en) * | 2010-04-16 | 2010-08-11 | 祝根华 | Quick-acting toothpaste for preventing and curing mouth diseases and periodontitis and production process thereof |
| CN101897658A (en) * | 2010-07-02 | 2010-12-01 | 中国科学院广州生物医药与健康研究院 | Mouth rinse for removing halitosis and preparation method thereof |
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Inventor after: Jin Bo Inventor before: Song Fanhua |
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Effective date of registration: 20170726 Address after: 201900 Shanghai city Baoshan District City Bank Road 555 Lane 7 Patentee after: Bader's (Shanghai) Polytron Technologies Inc Address before: 201107 Shanghai city Minhang District Minhang Road 88 Lane No. 1-30 building twenty-second room T159 Patentee before: Shanghai Fangmu Fine Chemical Co., Ltd. |
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Granted publication date: 20160316 Termination date: 20170813 |