CN102512349B - Morning and night heat-removing combination toothpaste and night heat-removing toothpaste - Google Patents

Morning and night heat-removing combination toothpaste and night heat-removing toothpaste Download PDF

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CN102512349B
CN102512349B CN 201210005856 CN201210005856A CN102512349B CN 102512349 B CN102512349 B CN 102512349B CN 201210005856 CN201210005856 CN 201210005856 CN 201210005856 A CN201210005856 A CN 201210005856A CN 102512349 B CN102512349 B CN 102512349B
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toothpaste
morning
fire
night
benefit
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CN102512349A (en
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陈敏珊
江山
吴远
陈素珍
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Guangzhou Shuke Industrial Co.,Ltd.
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GUANGZHOU WEIMEIZI PERSONAL CARE SUPPLIES CO Ltd
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Abstract

The invention discloses morning and night heat-removing combination toothpaste and night heat-removing toothpaste. The morning and night heat-removing combination toothpaste comprises an abradant, a humectant, a thickening agent, traditional Chinese medicinal components which are bacteriostatic, zinc citrate and a vinyl methyl ether/maleic anhydride copolymer. The invention provides the combination of morning toothpaste and night toothpaste which nurse the oral cavity in the morning and at night. The morning toothpaste has the effect of nursing teeth, the night toothpaste has the effect of enhancing for a long time, and the morning effect and the night effect are overlapped to ensure the health of the oral cavity. Dental plaques and dental calculus can be effectively prevented by using different toothpaste in the morning and at night, so the causes of parodontitis are eliminated radically, and the problems of gum bleeding, red and swollen gum and oral malodor can be effectively solved.

Description

The early beneficial late Qing Dynasty fire combined tooth-paste of benefit and beneficial late fire-clearing toothpaste
Technical field
The present invention relates to field of oral care, be specifically related to the early beneficial late Qing Dynasty fire combined tooth-paste of benefit and beneficial late fire-clearing toothpaste.
Background technology
Periodontitis is a kind of common oral disease, and its prevalence is up to more than 80% in China adult, and the main manifestations symptom is gingival hemorrhage, red swelling of gingiva, halitosis.It is many causes because of dental plaque and dental calculus.
Toothpaste is the main articles for daily use for cleaning, taking care of one's teeth, and it can remove dental plaque under the combined effect with toothbrush, reduces generation and the development of dental caries, tartar and gingivitis.Of a great variety for the toothpaste of maintenance gingiva in the market, the representative gum toothpaste that protects is mainly to be added with the effectively antipathogenic composition such as Chinese herbal medicine, and they all are improved problems such as gingival hemorrhage, red and swollen symptom and halitosiss.
Rhizoma Euonymus Ilicis Purpureae extract, contain the effective ingredient such as flavonoid glycoside, phenols, tannin, β-Amyrin and cupreol, has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, hemostatic and antibacterial.Gingival abscess, pericoronitis of the wisdom tooth, gingivitis and stomatitis etc. are all had to good curative effect.
Zinc citrate, as the additive of toothpaste, has the effect that prevents gingivitis, dental calculus and dental hemorrhage, even life-time service is also without any toxic and side effects.Then zinc citrate slowly releases metal ion easily be trapped in gingival sulcus in the process of brushing teeth in, and the growth of energy anti-bacteria, destroy the formation of bacterial plaque, and the deposition of pre-dental calculus preventing and pigment.
The mouth care idea of Chinese is comparatively backward, and most people's mouth care consciousness is thin.Less people recognizes that oral environment round the clock can be variant.Also few people understand that there is different demands in the different phase oral cavity to toothpaste efficiency sooner or later.Sooner or later use same fire-clearing toothpaste, can not effectively solve oral problem sooner or later.Existing fire-clearing toothpaste, only start with from formula, adds and have the functional component of bacteriostasis, and ignored the difference of oral environment sooner or later, is difficult to fundamentally control the formation of dental plaque and dental calculus.And three-dimensional fire-clearing toothpaste has not only been paid attention to the effect of toothpaste maintenance in night gingiva between morning sooner or later, and adopt the toothpaste of different efficacies to separately nursing of oral cavity for the difference in morning and evening oral cavity.
Summary of the invention
The object of the invention is to the difference according to dental plaque and dental calculus in the morning and evening oral cavity, the real solution oral environment of two toothpaste that is added with respectively the different efficacies composition nursing difficult problem of difference sooner or later is provided, reaches the purpose of inflammation such as improving red swelling of gingiva, gingival hemorrhage.
Because people's oral environment sooner or later can be variant usually, daytime, the salivation amount was many because of diet exchange, was unfavorable for the breeding of antibacterial; And evening oral cavity in relatively static state, the salivation amount reduces, bacterial growth speed is fast.Cause on relative daytime in the evening, more easily form dental plaque and dental calculus.Therefore sooner or later use same fire-clearing toothpaste, can not tackle the variation of oral environment sooner or later, can not effectively suppress the generation of dental plaque and dental calculus, gingival hemorrhage, red swelling of gingiva and halitosis treatment are difficult to reach positive effect.
The Chinese medicine extract of early fire-clearing toothpaste interpolation of benefit provided by the invention anti-inflammation, anti-bacteria, alleviate gingivitis, and select the odor type that mouthfeel is relatively strong effectively, makes implication feel more pure and fresh; Add the compositions of the complexing agent of Rhizoma Euonymus Ilicis Purpureae extract, PVM/MA high-molecular copolymer and zinc citrate-functional components such as the late factor of NFD benefit in the toothpaste used at night; the gum effect is protected in strengthening in the daytime; PVM/MA high-molecular copolymer wherein; can form protecting film at dental surface; functional component in toothpaste is slowly discharged in oral cavity; reach the effect of long-acting bacteriostatic, select pure and fresh fruital of releiving and fragrance of a flower odor type, can play the effect of calm sleeping.
The object of the invention is achieved through the following technical solutions:
The invention provides the early beneficial late Qing Dynasty fire of a kind of benefit combined tooth-paste, formed by the beneficial early fire-clearing toothpaste of use in morning and the benefit fire-clearing toothpaste in evening used evening;
The raw material of described benefit fire-clearing toothpaste morning comprises medicinal herb components and the pyrophosphate of abrasive, wetting agent, thickening agent, anti-inflammation, and parts by weight are as follows:
Abrasive: 20～50 parts
Wetting agent: 15～70 parts
Thickening agent: 0.5～2 part
The medicinal herb components of anti-inflammation: 0.1～2.0 part
Pyrophosphate: 0.1～2.0 part;
The raw material of the late fire-clearing toothpaste of described benefit comprises medicinal herb components, zinc citrate and the vinyl methyl ether/copolymer-maleic anhydride of abrasive, wetting agent, thickening agent, anti-inflammation, and parts by weight are as follows:
Abrasive: 20～50 parts
Wetting agent: 15～70 parts
Thickening agent: 0.5～2 part
The medicinal herb components of anti-inflammation: 0.1～2.0 part
Zinc citrate: 0.1～2.0 part
Vinyl methyl ether/copolymer-maleic anhydride: 0.01～5.0 part.
The medicinal herb components of described anti-inflammation preferred Rhizoma Euonymus Ilicis Purpureae extract or Folium Artemisiae Argyi extract.
The late fire-clearing toothpaste of described benefit and described benefit early fire-clearing toothpaste also comprise pyrophosphate, and parts by weight are 0.1～2.0 part.
The late fire-clearing toothpaste of described benefit and described benefit early fire-clearing toothpaste also comprise antiseptic, and parts by weight are 0.1～0.5 part.
Vinyl methyl ether/copolymer-maleic anhydride of the present invention and its preparation method are disclosed by prior art.
Another object of the present invention is to provide a kind of benefit late fire-clearing toothpaste.
The raw material of the late fire-clearing toothpaste of a kind of benefit comprises medicinal herb components, zinc citrate and the vinyl methyl ether/copolymer-maleic anhydride of abrasive, wetting agent, thickening agent, anti-inflammation, and parts by weight are as follows:
Abrasive: 20～50 parts
Wetting agent: 15～70 parts
Thickening agent: 0.5～2 part
The medicinal herb components of anti-inflammation: 0.1～2.0 part
Zinc citrate: 0.1～2.0 part
Vinyl methyl ether/copolymer-maleic anhydride: 0.01～5.0 part.
Also comprise pyrophosphate, parts by weight are 0.1～2.0 part.
Also comprise antiseptic, parts by weight are 0.1～0.5 part.
In the present invention's formula, described abrasive comprises more than one in natural whiting, silicon dioxide, dihydrogen phosphate dihydrate calcium, aluminium hydroxide, precipitated calcium carbonate, calcium phosphate dibasic anhydrous, anhydrous calcium pyrophosphate or calcium hydroxy phosphate.Described abrasive is the mixture of silicon dioxide and calcium carbonate particularly preferably
In the present invention's formula, wetting agent comprises more than one in sorbitol, glycerol, propylene glycol, Polyethylene Glycol, ethanol or xylitol.
In the present invention's formula, antiseptic comprises more than one in oxybenzene formicester, sodium benzoate, parabens, Kazon or Bronopol.
In the present invention's formula, thickening agent comprises more than one in hydroxyethyl-cellulose, sodium carboxymethyl cellulose, carboxymethyl cellulose, hydroxybutyl cellulose, hydroxypropyl methylcellulose, HANSHENGJIAO, xanthan gum, guar gum or carbomer.
In the present invention's formula, the medicinal herb components of anti-inflammation comprises that Rhizoma Euonymus Ilicis Purpureae extract, Folium Artemisiae Argyi extract etc. have the Chinese medicine extract of anti-inflammation effect.Preferred Rhizoma Euonymus Ilicis Purpureae extract or Folium Artemisiae Argyi extract.
In the present invention formula, pyrophosphate comprises more than one in the material of the anti-dental calculuss such as tetrasodium pyrophosphate or tetrapotassium pyrophosphate.
The advantage that the present invention has with respect to prior art and beneficial effect:
(1) the present invention has designed morning and evening two toothpaste in classification nursing morning and evening oral cavity, the toothpaste efficiency used morning nursing, and the long-acting consolidation of toothpaste that used evening, allow effect sooner or later superpose, and takees good care of oral health comprehensively.
(2) for the oral environment of uniqueness at night, add unique long-acting nursing composition in the three-dimensional fire-clearing toothpaste used at night: the compositions of the complexing agent of PVM/MA high-molecular copolymer and zinc citrate-NFD late factor of benefit and Rhizoma Euonymus Ilicis Purpureae extract, can long-acting inhibition dental plaque and the generation of dental calculus.
(3) for the oral environment on daytime, in the three-dimensional fire-clearing toothpaste used in the morning, interpolation Rhizoma Euonymus Ilicis Purpureae extract and tetrasodium pyrophosphate can reach antibacterial and antilithic effect.Sooner or later three-dimensional fire-clearing toothpaste can effectively suppress the generation of dental plaque and dental calculus, has fundamentally solved the cause of disease of periodontitis, can effectively improve gingival hemorrhage, red swelling of gingiva and halitosis problem.
The specific embodiment
Embodiment 1
The early beneficial late Qing Dynasty fire of benefit combined tooth-paste is comprised of the beneficial early fire-clearing toothpaste of use in morning and the benefit fire-clearing toothpaste in evening used evening:
A. the three-dimensional fire-clearing toothpaste formula used morning:
100 parts of total amounts
18 parts of sorbitol
Polyethylene Glycol-12 2 part
0.1 part of methyl hydroxybenzoate
0.8 part of sodium carboxymethyl cellulose
0.2 part of HANSHENGJIAO
0.8 part of tetrasodium pyrophosphate
0.2 part of saccharin sodium
Carbonic acid Ca45 part
4 parts, hydration Silicon stone
0.4 part of calcium hydrogen phosphate
1.5 parts of Rhizoma Euonymus Ilicis Purpureae extracts
2.2 parts of lauric acid sodium sulfovinates
1.2 parts, essence
0.1 part of pigment
The deionized water surplus
Accurately take saccharin sodium and tetrasodium pyrophosphate by above-mentioned formula, add sorbitol after adding deionized water dissolving; Separately methyl hydroxybenzoate heating is dissolved in Polyethylene Glycol-12, adds sodium carboxymethyl cellulose and HANSHENGJIAO to stir after cooling; Calcium carbonate, hydration Silicon stone, calcium hydrogen phosphate, Rhizoma Euonymus Ilicis Purpureae extract, lauric acid sodium sulfovinate, essence, pigment will be added after both mix homogeneously.The final vacuum that stirs is degassed, fill.
B. the three-dimensional fire-clearing toothpaste formula used evening
100 parts of total amounts
Sorbitol 20
Polyethylene Glycol-12 3
Glycerol 10
Methyl hydroxybenzoate 0.1
Sodium carboxymethyl cellulose 0.6
HANSHENGJIAO 0.5
Tetrasodium pyrophosphate 0.8
Saccharin sodium 0.2
Calcium carbonate 43
Hydration Silicon stone 4
Zinc citrate 1.0
Calcium hydrogen phosphate 0.5
Rhizoma Euonymus Ilicis Purpureae extract 1.5
Gantrez AN-119 2
Lauric acid sodium sulfovinate 2.2
Essence 1.2
Pigment 0.1
The deionized water surplus
Accurately take saccharin sodium and tetrasodium pyrophosphate by above-mentioned formula, add sorbitol after adding deionized water dissolving; Separately methyl hydroxybenzoate heating is dissolved in Polyethylene Glycol-12 and glycerol, adds sodium carboxymethyl cellulose and HANSHENGJIAO to stir after cooling; Calcium carbonate, hydration Silicon stone, zinc citrate, calcium hydrogen phosphate, Rhizoma Euonymus Ilicis Purpureae extract, Gantrez AN-119, lauric acid sodium sulfovinate, essence, pigment will be added after both mix homogeneously.The final vacuum that stirs is degassed, fill.
The benefit of using morning early after fire-clearing toothpaste and the benefit fire-clearing toothpaste in evening that uses evening to the clinical verification of dental plaque:
(1) object of observation:
177 people of selected improvement Quigley-Hein plaque index >=1.5 and Lee-Silneaa index of gingivitis >=1.0 participate in research.Experimental group 89 people, matched group matched group 88 people.
(2) plaque index detection method:
Adopt the Turesky plaque index of Quigley-Heln improvement to estimate supragingival plaque.To supragingival plaque dyeing and according to following standard recording:
0=is without bacterial plaque;
The bacterial plaque that 1=neck section marginal existence is dispersed in;
The visible continuous thin bacterial plaque band (reaching I mm wide) in 2=neck edge ;
3=neck section bacterial plaque band is greater than 1mm, but is less than 1/3 of facing;
The 4=bacterial plaque covers 1/3-2/3 of facing;
The 5=bacterial plaque covers facing more than 2/3.
Tooth detection buccal surface and lingual surface are earnestly 10 for the maximum note of each tooth.Each experimenter's plaque index all earnestly by the whole tooth detection gained of individual counting sums (each tooth 2 face), divided by total measurement honest (teeth number is multiplied by 2), obtain numerical value.
(3) experimental technique:
The participant is completed to the inspection of bacterial plaque baseline.And be divided into two balance groups.Use embodiment 1 configuration combined tooth-paste be experimental group, the employing ordinary toothpaste be matched group.When using 3 months and 6 months, the program to experimenter's dental plaque situation according to the baseline inspection is detected.
(4) testing result and discussion:
The Clinical detection of the baseline check result of object of study and 3 months and 6 months the results are shown in Table 1:
Figure DEST_PATH_IMAGE001
From the Clinical detection result of 3 months and 6 months, experimental group than matched group the dental plaque slip be respectively 12.3% and 31.4%, the effect highly significant, the combined tooth-paste therefore used has the effect that significantly reduces dental plaque.
Embodiment 2
The benefit three-dimensional fire-clearing toothpaste formula in evening used evening
100 parts of total amounts
Sorbitol 17
Polyethylene Glycol-12 3
Glycerol 2
Methyl hydroxybenzoate 0.5
Sodium carboxymethyl cellulose 0.2
HANSHENGJIAO 0.3
Tetrasodium pyrophosphate 2
Calcium carbonate 16
Hydration Silicon stone 4
Zinc citrate 2.0
Calcium hydrogen phosphate 0.5
Rhizoma Euonymus Ilicis Purpureae extract 0.1
Gantrez AN-119 5
Lauric acid sodium sulfovinate 2.2
Essence 1.2
Pigment 0.1
The deionized water surplus
the clinical verification of the benefit three-dimensional fire-clearing toothpaste in evening used evening to dental calculus
Selection has volunteer 58 people of severe tartar (calculus index >=3.0), male 25 people, female 33 people.Check those selected situation of brushing teeth by the compliance measure, and measure calculus index, the record of filling in a form.Each object of observation is done to supragingival scaling, remove supragingival calculus.The benefit three-dimensional fire-clearing toothpaste (experimental group) in evening that embodiment 2 is configured to and ordinary toothpaste (matched group) random packet, to the experimenter, require to brush teeth in accordance with regulations.Experiment adopts double-blind method, and same doctor checks calculus index in first visit with after 3 months with habitual in the world V-M index respectively.Experimental result is done statistical analysis with rank test.The results are shown in Table 2:
Table 2
Figure DEST_PATH_IMAGE002
Two groups of tartar are poor does statistical calculations through rank test, and result is P<0. 02, illustrates that the benefit toothpaste in evening by embodiment 2 configurations has the effect that more obviously suppresses dental calculus.Its main cause is to be added with unique long-acting nursing composition in the late toothpaste of the present invention benefit: PVM/MA high-molecular copolymer, zinc citrate and Rhizoma Euonymus Ilicis Purpureae extract, and can long-acting inhibition dental plaque and the generation of dental calculus.
In addition, the rank of dental calculus and than matched group height one times can illustrate that the late toothpaste of the present invention benefit adds unique long-acting nursing composition: PVM/MA high-molecular copolymer, zinc citrate and Rhizoma Euonymus Ilicis Purpureae extract, can long-acting inhibition dental plaque and the generation of dental calculus.
The announcement of book and instruction according to the above description, those skilled in the art in the invention can also be changed and be revised above-mentioned embodiment.Therefore, the present invention is not limited to the specific embodiment disclosed and described above, to modifications and changes more of the present invention, also should fall in the protection domain of claim of the present invention.In addition, although used some specific terms in this description, these terms just for convenience of description, do not form any restriction to the present invention.

Claims (2)

1. the early beneficial late Qing Dynasty fire of benefit combined tooth-paste, is characterized in that, the beneficial early fire-clearing toothpaste of use in morning and the benefit fire-clearing toothpaste in evening used evening, consists of;
The raw material of described benefit fire-clearing toothpaste morning comprises medicinal herb components and the pyrophosphate of antiseptic, abrasive, wetting agent, thickening agent, anti-inflammation, and the described benefit early every 100 parts of parts by weight that comprise of fire-clearing toothpaste is as follows:
Figure FDA00003115445300011
The raw material of the late fire-clearing toothpaste of described benefit comprises medicinal herb components, zinc citrate and the vinyl methyl ether/copolymer-maleic anhydride of antiseptic, abrasive, wetting agent, thickening agent, anti-inflammation, and the every 100 parts of parts by weight that comprise of the late fire-clearing toothpaste of described benefit are as follows:
Figure FDA00003115445300012
2. the late fire-clearing toothpaste of benefit, it is characterized in that, raw material comprises medicinal herb components, zinc citrate and the vinyl methyl ether/copolymer-maleic anhydride of antiseptic, abrasive, wetting agent, thickening agent, anti-inflammation, and the every 100 parts of parts by weight that comprise of the late fire-clearing toothpaste of described benefit are as follows:
Figure FDA00003115445300022
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CN105232428A (en) * 2015-11-12 2016-01-13 施德望 High-efficiency enhancing night-benefiting toothpaste with functional active ingredients added and preparation method
CN106109357B (en) * 2016-08-25 2019-04-12 青岛魁宇本草生物科技有限公司 A kind of toothpaste and preparation method thereof
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