CN101897658A - Mouth rinse for removing halitosis and preparation method thereof - Google Patents
Mouth rinse for removing halitosis and preparation method thereof Download PDFInfo
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- CN101897658A CN101897658A CN2010102179145A CN201010217914A CN101897658A CN 101897658 A CN101897658 A CN 101897658A CN 2010102179145 A CN2010102179145 A CN 2010102179145A CN 201010217914 A CN201010217914 A CN 201010217914A CN 101897658 A CN101897658 A CN 101897658A
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- mouth rinse
- herbal medicine
- chinese herbal
- removing halitosis
- halitosis
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- 206010006326 Breath odour Diseases 0.000 title claims abstract description 46
- 208000032139 Halitosis Diseases 0.000 title claims abstract description 46
- 239000002324 mouth wash Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 29
- 241000411851 herbal medicine Species 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000008367 deionised water Substances 0.000 claims abstract description 19
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 19
- 229940079593 drug Drugs 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 17
- 239000004094 surface-active agent Substances 0.000 claims abstract description 15
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011187 glycerol Nutrition 0.000 claims abstract description 10
- 229960000282 metronidazole Drugs 0.000 claims abstract description 9
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 9
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 26
- 241000628997 Flos Species 0.000 claims description 23
- 239000007788 liquid Substances 0.000 claims description 19
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- IPWKIXLWTCNBKN-UHFFFAOYSA-N Madelen Chemical compound CC1=NC=C([N+]([O-])=O)N1CC(O)CCl IPWKIXLWTCNBKN-UHFFFAOYSA-N 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 229960002313 ornidazole Drugs 0.000 claims description 6
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims description 5
- 229960005053 tinidazole Drugs 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 238000002386 leaching Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 229960003943 hypromellose Drugs 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 16
- 210000000214 mouth Anatomy 0.000 description 15
- 208000015181 infectious disease Diseases 0.000 description 7
- 238000012360 testing method Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical compound OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 241001046548 Anaerobium Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The method discloses a mouth rinse for removing halitosis and a preparation method thereof. The mouth rinse for removing halitosis comprises nidazole medicines, Chinese herbal medicine extracts, menthol, glycerin, a surface active agent and deionized water. In the invention, the mouth rinse for removing halitosis takes the nidazole medicines as a main therapeutic ingredient, and enhances therapeutic effect by adding the Chinese herbal medicine extracts for health care. Compared with the mouth rinse with a single active ingredient, the mouth rinse of the invention can be applicable to more indications, has more obvious therapeutic effect on removing oral abnormal odor, can effectively improve oral inflammation without destroying normal oral floras, and has the advantages of short use time, good drug resistance, convenient use, good mouth feel and easy acceptance of patients.
Description
Technical field
The present invention relates to a kind of mouth rinse for removing halitosis and preparation method thereof.
Background technology
Halitosis is by anaerobe, and the food fermentation that perhaps residues in the oral cavity produces due to the sulfide.In the oral cavity infection patient, the anaerobic infection rate accounts for 96% in odontogenic infection, and non-odontogenic infection accounts for 73.7%, and the visible proportion of anaerobe in oral cavity infection is big.For making the disease of patient treatment obtain better curative effect, require the patient after clinical improvement, to be used collutory.Therefore, select suitable anti-anaerobism collutory, become the important step of treatment oral cavity anaerobium infectious disease.
(Food and Drug Administration, FDA) Ren Zheng collutory has two classes: contain quintessence oil and the collutory that contains hibitane for U.S. food and drug administration.Quintessence oil class collutory alcohol content is higher, can cause the easier infiltration of carcinogen oral cavity inwalls such as nicotine, and the carcinogenic product acetaldehyde of the metabolism of ethanol is piled up in the oral cavity by the process of gargling easily.The shortcoming that contains the collutory life-time service of hibitane is to cause that easily tartar forms, facing is painted and the sense of taste changes.
Given this, the specific nitre azole drug of anaerobe (metronidazole, tinidazole and ornidazole) is used in a large number, becomes routine administration.Chinese patent application number is 200510013566.9, and denomination of invention is ornidazole gargarisma and preparation method thereof, discloses a kind of collutory that comprises ornidazole, and the treatment of the oral diseases such as periodontal disease of non-systemic infection is had curative effect.Yet the collutory effective ingredient of this patent disclosure is single, and suitable disease is wideless, and curative effect is not remarkable.
Summary of the invention
The object of the present invention is to provide a kind of new mouth rinse for removing halitosis.
For achieving the above object, the present invention has taked following technical scheme:
A kind of mouth rinse for removing halitosis, in weight percentage, this collutory comprises following component:
Nitre azole drug 0.001～0.7%
Chinese herbal medicine extract 0.05～0.2%
Mentholum 0.01～0.03%
Glycerol 1～5%
Surfactant 0.1～0.3%
Deionized water adds to 100%
Described Chinese herbal medicine extract comprises the extract of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi and Herba Lophatheri.
Preferably, described Chinese herbal medicine extract also comprises the extract of Flos Lonicerae and/or Rhizoma Smilacis Glabrae; Preferably, in weight percentage, described mouth rinse for removing halitosis also comprises 0.05～0.2% essence.
More preferably, in weight percentage, this collutory comprises following component:
Nitre azole drug 0.05～0.2%
Chinese herbal medicine extract 0.1～0.2%
Mentholum 0.01～0.02%
Glycerol 2～3%
Surfactant 0.1～0.2%
Deionized water adds to 100%
Described Chinese herbal medicine extract is the extract of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi, Herba Lophatheri, Flos Lonicerae and Rhizoma Smilacis Glabrae.
Described nitre azole drug is one or more in metronidazole, tinidazole and the ornidazole; Described surfactant is one or more in sarcosyl, hypromellose sodium and the sodium carboxymethyl cellulose.
The present invention also provides the preparation method of above-mentioned mouth rinse for removing halitosis.
A kind of preparation method of mouth rinse for removing halitosis may further comprise the steps:
(1) fully soak the Chinese herbal medicine after-filtration with hot water and ethanol successively, filtrate merges the back concentrating under reduced pressure and gets Chinese herbal medicine extract; Get the mixed liquor that described Chinese herbal medicine extract is dissolved in deionized water, glycerol, surfactant, get A liquid;
(2) Mentholum is ground be mixed in the A liquid B liquid;
(3) the nitre azole drug is dissolved in the deionized water C liquid;
(4) with after the described B liquid of step (2), the described C liquid mixing of step (3), add deionized water, fully stir, cross leaching filtrate promptly to full dose.
It is main component that the present invention's employing has the nitre azole drug of special efficacy to the anaerobe that causes halitosis; Adding has the Chinese herbal medicine extract (mainly being Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi and Herba Lophatheri) of caring effect to the oral cavity, and the antibacterial and balance oral cavity normal flora of collaborative nitre azole drug is to strengthen therapeutic effect; Adding has the bitterness that refrigerant tasty and refreshing Mentholum is corrected the nitre azole drug, and is easy for patients to accept; Be aided with viscosity and prolongation the holdup time in oral cavity of glycerol, heighten the effect of a treatment and mouthfeel, simultaneously also as the auxiliary solvent of Mentholum in water to increase collutory; Be equipped with surfactant hydrotropy and adjuvants such as an amount of essence, deionized water at last.
Compared with prior art, the present invention has following beneficial effect:
Mouth rinse for removing halitosis of the present invention is main therapeutic component with the nitre azole drug, and the Chinese herbal medicine extract caring heightens the effect of a treatment in addition; Compared to the collutory of single active ingredient, it is wider that collutory of the present invention is suitable for disease, removes oral cavity foreign odor more remarkable effect, can improve oral inflammation and not destroy the oral cavity normal flora, service time is short, and drug resistance is good, easy to use, good mouthfeel, easy for patients to accept.
The specific embodiment
The part by weight of the Chinese herbal medicine in following examples is a preferred version, but be not limited to this, the approximate weight ratio of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi, Herba Lophatheri, Flos Lonicerae and Rhizoma Smilacis Glabrae is 10～20: 15～25 usually: 25～35: 5～15: 25～35: 15～25.
Embodiment 1
A kind of mouth rinse for removing halitosis comprises following component:
Ornidazole and tinidazole 0.5g
Chinese herbal medicine (Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi and Herba Lophatheri) extract 1.0g
Mentholum 0.2g
Glycerol (glycerol) 20mL
Surfactant (sodium carboxymethyl cellulose) 1.0g
Deionized water adds to 1000mL
The mouth rinse for removing halitosis of embodiment 1 is to get by the following steps preparation:
(1) according to a conventional method, (the approximate weight ratio of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi and Herba Lophatheri is 15: 20: 30: 10 to get Chinese herbal medicine.) fully soak with hot water and ethanol successively after, the gained liquid filtering, filtrate merges the back concentrating under reduced pressure and gets Chinese herbal medicine extract, gets the mixed liquor that this Chinese herbal medicine extract is dissolved in deionized water, glycerol, surfactant, A liquid;
(2) the Mentholum grinding is mixed in the A liquid, gets B liquid;
(3) metronidazole is dissolved in the aqueous solution that must contain metronidazole 10～20% in the deionized water, gets C liquid;
(4) with after above-mentioned B liquid, the mixing of C liquid, add deionized water, fully stir, cross leaching filtrate promptly to full dose.
Use the collutory of this embodiment to gargle 30 seconds, it is respond well to remove the oral cavity foreign odor.
Embodiment 2
A kind of mouth rinse for removing halitosis comprises following component:
Metronidazole 5.0g
Chinese herbal medicine (Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi and Herba Lophatheri) extract 2.0g
Mentholum 0.3g
Glycerol (glycerol) 18mL
Surfactant (sodium carboxymethyl cellulose) 3.0g
Deionized water adds to 1000mL
The approximate weight ratio of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi and Herba Lophatheri is 15: 20: 30: 10.
The mouth rinse for removing halitosis for preparing present embodiment according to the preparation method of embodiment 1.Use the collutory of this embodiment to gargle 30 seconds, it is relatively good to remove oral cavity foreign odor effect.
Embodiment 3
A kind of mouth rinse for removing halitosis comprises following component:
Tinidazole 0.05g
Chinese herbal medicine (Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi, Herba Lophatheri, Flos Lonicerae and Rhizoma Smilacis Glabrae) extract 2.0g
Mentholum 0.1g
Glycerol 25mL
Surfactant (sarcosyl) 1.0g
Essence 1.0g
Deionized water adds to 1000mL
The approximate weight ratio of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi, Herba Lophatheri, Flos Lonicerae and Rhizoma Smilacis Glabrae is 15: 20: 30: 10: 30: 20.
The mouth rinse for removing halitosis (in step 4, adding essence) for preparing present embodiment according to the preparation method of embodiment 1.Use the collutory of this embodiment to gargle 30 seconds, it is relatively good to remove oral cavity foreign odor effect.
Embodiment 4
A kind of mouth rinse for removing halitosis comprises following component:
Metronidazole 2.0g
Chinese herbal medicine (Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi, Herba Lophatheri, Flos Lonicerae and Rhizoma Smilacis Glabrae) extract 1.0g
Mentholum 0.1g
Glycerol (glycerol) 20mL
Surfactant (sarcosyl) 1.0g
Essence 1.0g
Deionized water adds to 1000mL
The approximate weight ratio of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi, Herba Lophatheri, Flos Lonicerae and Rhizoma Smilacis Glabrae is 15: 20: 30: 10: 30: 20.
The mouth rinse for removing halitosis for preparing present embodiment according to the preparation method (in step 4, adding essence) of embodiment 1.Use the collutory of this embodiment to gargle 30 seconds, it is better slightly than the effect of embodiment 1 to remove oral cavity foreign odor effect, but more remarkable than embodiment 2 and 3.
The test example
1. halitosis classification
Adopt direct olfactory sensation method (direct sniffing-organoleptic method) that halitosis is divided into six grades, standards at different levels are respectively:
One-level: no halitosis;
Secondary: very slight halitosis;
Three grades: slight halitosis;
Level Four: moderate halitosis;
Pyatyi: strong halitosis;
Six grades: very intensive halitosis.
2. test collutory
Test group: the mouth rinse for removing halitosis that uses embodiment 3;
Matched group: the reference substance collutory comprises other all components except that Chinese herbal medicine extract of embodiment 4.
3. test method and result
There is the volunteer of level Four or above halitosis to gargle 30 seconds, accepts the halitosis classified estimation again after 2 hours at mouth rinse for removing halitosis and matched group collutory with embodiment 3.Rank reduces secondary or above person is a produce effects; It is effective reducing one-level person; The no change person is invalid.
The halitosis rank value of volunteer before and after gargling done pairing t-check.
Test group result shows that in 100 volunteers that the mouth rinse for removing halitosis of use embodiment 3 is gargled, produce effects person is 85 people (85%), and the responder is 14 people (14%), nonresponder 1 people (1%), and total effective rate is 99%.Pairing t-assay has significance (P＜0.01).
The matched group result shows that in 87 volunteers that use reference substance collutory is gargled, produce effects person is 46 people (52.9%), and the responder is 33 people (37.9%), nonresponder 8 people (5.7%), and total effective rate is 90.8%.Pairing t-assay has significance (P＜0.01).
4. conclusion
Volunteer investigation through two groups of experiments shows that compared to matched group, the halitosis of test group volunteer is removed more remarkable effect, and oral inflammations such as while periodontitis have clear improvement, and taste is easier to be accepted.
Use the mouth rinse for removing halitosis of embodiment 1-3, through above-mentioned identical experiment, find also can reach good halitosis and remove effect, concrete data are omitted.
Claims (7)
1. a mouth rinse for removing halitosis is characterized in that, in weight percentage, this collutory comprises following component:
Nitre azole drug 0.001～0.7%
Chinese herbal medicine extract 0.05～0.2%
Mentholum 0.01～0.03%
Glycerol 1～5%
Surfactant 0.1～0.3%
Deionized water adds to 100%
Described Chinese herbal medicine extract comprises the extract of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi and Herba Lophatheri.
2. mouth rinse for removing halitosis according to claim 1 is characterized in that described Chinese herbal medicine extract also comprises the extract of Flos Lonicerae and/or Rhizoma Smilacis Glabrae.
3. mouth rinse for removing halitosis according to claim 1 is characterized in that, in weight percentage, this collutory comprises following component:
Nitre azole drug 0.05～0.2%
Chinese herbal medicine extract 0.1～0.2%
Mentholum 0.01～0.02%
Glycerol 2～3%
Surfactant 0.1～0.2%
Deionized water adds to 100%
Described Chinese herbal medicine extract is the extract of Herba Lobeliae Chinensis, Galla Chinensis, Flos Chrysanthemi, Herba Lophatheri, Flos Lonicerae and Rhizoma Smilacis Glabrae.
4. according to the described mouth rinse for removing halitosis of claim 1-3, it is characterized in that in weight percentage, this collutory also comprises 0.05～0.2% essence.
5. mouth rinse for removing halitosis according to claim 1 is characterized in that, described nitre azole drug is one or more in metronidazole, tinidazole and the ornidazole.
6. mouth rinse for removing halitosis according to claim 1 is characterized in that, described surfactant is one or more in sarcosyl, hypromellose sodium and the sodium carboxymethyl cellulose.
7. the preparation method of claim 1 or 2 described mouth rinse for removing halitosis is characterized in that, may further comprise the steps:
(1) fully soak the Chinese herbal medicine after-filtration with hot water and ethanol successively, filtrate merges the back concentrating under reduced pressure and gets Chinese herbal medicine extract; Get the mixed liquor that described Chinese herbal medicine extract is dissolved in deionized water, glycerol, surfactant, get A liquid;
(2) Mentholum is ground be mixed in the A liquid B liquid;
(3) the nitre azole drug is dissolved in the deionized water C liquid;
(4) with after the described B liquid of step (2), the described C liquid mixing of step (3), add deionized water, fully stir, cross leaching filtrate promptly to full dose.
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| CN2010102179145A CN101897658B (en) | 2010-07-02 | 2010-07-02 | Mouth rinse for removing halitosis and preparation method thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103462819A (en) * | 2013-08-13 | 2013-12-25 | 上海方木精细化工有限公司 | Toothpaste suitable for oral ulcer patients |
| ITMI20130892A1 (en) * | 2013-05-31 | 2014-12-01 | Ver Alit S A S Di Furbini Sparta Co | COMPOSITION IN THE FORM OF STRUCTURAL OR GEL FOR USE IN THE TREATMENT OF HUMAN OR ANIMAL PERMANENT ALITOSIS WITH BACTERIAL ETIOLOGY |
| CN104739742A (en) * | 2015-03-04 | 2015-07-01 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine mouth wash for treating gum bleeding and preparation method of traditional Chinese medicine mouth wash |
| CN104873418A (en) * | 2015-05-18 | 2015-09-02 | 李学刚 | Oral care solution |
| CN106109366A (en) * | 2016-08-30 | 2016-11-16 | 南京巨鲨显示科技有限公司 | A kind of collutory and preparation method thereof |
| CN107714595A (en) * | 2016-08-12 | 2018-02-23 | 张彬梅 | One kind cleaning mouthwash formula and production method |
| CN107714569A (en) * | 2017-12-07 | 2018-02-23 | 威海职业学院 | A kind of preparation method of fragrant plant mouthwash |
| CN107744491A (en) * | 2017-11-27 | 2018-03-02 | 钱卫萍 | A kind of mouth rinse for removing halitosis |
| CN108653072A (en) * | 2017-03-29 | 2018-10-16 | 黄月 | A kind of botanical herbs mouthwash |
| CN112675059A (en) * | 2021-01-08 | 2021-04-20 | 安徽万光生物科技有限公司 | Mouthwash containing didecyl dimethyl ammonium chloride and preparation method thereof |
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|---|---|---|---|---|
| CN101574445A (en) * | 2008-05-08 | 2009-11-11 | 党化宁 | Traditional Chinese medicine composition with oral health efficacy |
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