CN104739742A - Traditional Chinese medicine mouth wash for treating gum bleeding and preparation method of traditional Chinese medicine mouth wash - Google Patents
Traditional Chinese medicine mouth wash for treating gum bleeding and preparation method of traditional Chinese medicine mouth wash Download PDFInfo
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- CN104739742A CN104739742A CN201510095723.9A CN201510095723A CN104739742A CN 104739742 A CN104739742 A CN 104739742A CN 201510095723 A CN201510095723 A CN 201510095723A CN 104739742 A CN104739742 A CN 104739742A
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Abstract
The invention discloses a traditional Chinese medicine mouth wash for treating gum bleeding and a preparation method of the traditional Chinese medicine mouth wash, and belongs to the traditional Chinese medicine field. The Chinese medicine mouth wash comprises the raw materials: 4-10 parts of honeysuckle solution extract, 3-7 parts of Chinese Gall alcohol extract, 5-10 parts of pseudo-ginseng alcohol extract, 2-5 parts of cherokee rose fruit ethyl acetate extract, 4-7 parts of subprostrate sophora ethyl acetate extract, 4-9 parts of tween-60, 3-6 parts of span-40, 4-8 parts of glycerinum, 5-10 parts of sodium carboxymethylcellulose and 250-350 parts of water. The preparation method of the traditional Chinese medicine mouth wash comprises the steps of crushing, heating, stirring, extracting, centrifuging, concentrating in vacuum and stirring to obtain the traditional Chinese medicine mouth wash for treating the gum bleeding. The prepared traditional Chinese medicine mouth wash can effectively prevent the gum bleeding.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of collutory and preparation method thereof, particularly relate to a kind of Chinese medicine mouth wash preventing and treating gingival hemorrhage and preparation method thereof.
Background technology
Gingival hemorrhage is one of department of stomatology common sympton, and what refer to that gingiva is idiopathic or cause due to minimal irritation bleeds on a small quantity.The lighter show as only sucking, brush teeth, when chewing harder food in saliva with the blood streak, severe one is when gingiva is subject to minimal irritation and hemorrhage more even hematostaxis.Generally speaking, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingival hemorrhage is more common in periodontitis and gingivitis patients.Cause the reason of gingival hemorrhage to have: 1, a lot of dental calculus is attached to neck portion, having a lot of pathogenic bacterias stimulates gingiva, causes various focusing depths represented, occurs the phenomenon of gingival hemorrhage.If the cavity on 2 teeth is mended not in time, just likely can stimulate gingiva, cause gingival hemorrhage.3, periodontitis is modal phenomenon, due to the lesion tissue of tooth surrounding, makes gingival edema, telangiectasis hyperemia, once chew harder food or brush teeth not at that time, often can cause gingival hemorrhage.The method for the treatment of gingival hemorrhage is also more, by taking Chinese medicine or alleviating with mouthwash and cure.The Chinese medicine mouth wash of conventional control gingival hemorrhage is less, and the effect of its control gingival hemorrhage is also poor.
Summary of the invention
The technical problem solved: the object of this invention is to provide a kind of Chinese medicine mouth wash preventing gingival hemorrhage and preparation method thereof, solves conventional collutory curative effect in control gingival hemorrhage not remarkable, can not effectively to the problem that gingival hemorrhage is prevented and treated.
Technical scheme: the invention discloses a kind of Chinese medicine mouth wash preventing and treating gingival hemorrhage and preparation method thereof, the Chinese medicine mouth wash of described control gingival hemorrhage comprises following composition by weight:
Honeysuckle aqueous extract 4-10 part,
Galla Chinensis ethanol extraction 3-7 part,
Radix Notoginseng ethanol extraction 5-10 part,
Fructus Rosae Laevigatae ethyl acetate extract 2-5 part,
Radix Sophorae Tonkinensis ethyl acetate extract 4-7 part,
Tween-60 4-9 part,
Si Ban-40 3-6 part,
Glycerol 4-8 part,
Sodium carboxymethyl cellulose 5-10 part,
Water 250-350 part.
Further, described a kind of Chinese medicine mouth wash preventing and treating gingival hemorrhage, comprises following composition by weight:
Honeysuckle aqueous extract 5-8 part,
Galla Chinensis ethanol extraction 4-6 part,
Radix Notoginseng ethanol extraction 6-9 part,
Fructus Rosae Laevigatae ethyl acetate extract 3-4 part,
Radix Sophorae Tonkinensis ethyl acetate extract 5-6 part,
Tween-60 6-8 part,
Si Ban-40 4-5 part,
Glycerol 5-7 part,
Sodium carboxymethyl cellulose 6-9 part,
Water 280-330 part.
Further, described a kind of Chinese medicine mouth wash preventing and treating gingival hemorrhage, comprises following composition by weight:
Honeysuckle aqueous extract 7 parts,
Galla Chinensis ethanol extraction 5 parts,
Radix Notoginseng ethanol extraction 8 parts,
Fructus Rosae Laevigatae ethyl acetate extract 3 parts,
Radix Sophorae Tonkinensis ethyl acetate extract 6 parts,
Tween-60 7 parts,
Si Ban-40 5 parts,
Glycerol 6 parts,
Sodium carboxymethyl cellulose 8 parts,
310 parts, water.
Prevent and treat a preparation method for the Chinese medicine mouth wash of gingival hemorrhage, the preparation method of described Chinese medicine mouth wash comprises the following steps:
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain honeysuckle aqueous extract and Galla Chinensis water extract respectively;
(2), after being pulverized with pulverizer by Radix Notoginseng, stirring solvent extraction is carried out with ethanol, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction;
(3) by after Fructus Rosae Laevigatae and Radix Sophorae Tonkinensis drying, carry out mechanical activation comminution again, stirring solvent extraction is carried out by ethyl acetate after pulverizing, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract respectively;
(4) extracting honeysuckle water extract 4-10 part, Galla Chinensis ethanol extraction 3-7 part, Radix Notoginseng ethanol extraction 5-10 part, Fructus Rosae Laevigatae ethyl acetate extract 2-5 part, Radix Sophorae Tonkinensis ethyl acetate extract 4-7 part, Tween-60 are 4-9 part respectively by weight, Si Ban-40 is 3-6 part, glycerol is 4-8 part, sodium carboxymethyl cellulose is 5-10 part, water is 250-350 part, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
Described a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage, in step (1), Flos Lonicerae and Chinese Gall deionized water are carried out feed liquid weight ratio when heated and stirred is extracted and be 1:4, heating-up temperature is 70 DEG C, and heat time heating time is 3h.
Described a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage, after being pulverized with pulverizer by Radix Notoginseng in step (2), when carrying out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, and heating-up temperature is 50 DEG C, and heat time heating time is 4h.
Described a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage, the feed liquid weight ratio that the middle Fructus Rosae Laevigatae of step (3) and Radix Sophorae Tonkinensis ethyl acetate carry out stirring solvent extraction is 1:10, and heating-up temperature is 40 DEG C, and heat time heating time is 3h.
Described a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage, in step (4), speed of agitator is 50rpm-200rpm.
Beneficial effect: the Chinese medicine mouth wash of control gingival hemorrhage of the present invention is different from conventional collutory, antimicrobial component basis adds Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract, improves the curative effect of Chinese medicine mouth wash of the present invention on control gingival hemorrhage significantly.
Detailed description of the invention
Embodiment 1
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, and feed liquid weight ratio is 1:4, heating-up temperature is 70 DEG C, heat time heating time is 3h, after extraction, extracting solution is centrifugal, discards precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains honeysuckle aqueous extract and Galla Chinensis water extract respectively; (2), after being pulverized with pulverizer by Radix Notoginseng, carry out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, heating-up temperature is 50 DEG C, and heat time heating time is 4h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction; (3) by after Fructus Rosae Laevigatae and Radix Sophorae Tonkinensis drying, carry out mechanical activation comminution again, stirring solvent extraction is carried out by ethyl acetate after pulverizing, feed liquid weight ratio is 1:10, and heating-up temperature is 40 DEG C, and heat time heating time is 3h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract respectively; (4) extracting honeysuckle water extract 10 parts, Galla Chinensis ethanol extraction 3 parts, Radix Notoginseng ethanol extraction 5 parts, Fructus Rosae Laevigatae ethyl acetate extract 5 parts, Radix Sophorae Tonkinensis ethyl acetate extract 7 parts, Tween-60 are 4 parts respectively by weight, Si Ban-40 is 6 parts, glycerol is 8 parts, sodium carboxymethyl cellulose is 5 parts, water is 350 parts, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
Embodiment 2
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, and feed liquid weight ratio is 1:4, heating-up temperature is 70 DEG C, heat time heating time is 3h, after extraction, extracting solution is centrifugal, discards precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains honeysuckle aqueous extract and Galla Chinensis water extract respectively; (2), after being pulverized with pulverizer by Radix Notoginseng, carry out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, heating-up temperature is 50 DEG C, and heat time heating time is 4h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction; (3) by after Fructus Rosae Laevigatae and Radix Sophorae Tonkinensis drying, carry out mechanical activation comminution again, stirring solvent extraction is carried out by ethyl acetate after pulverizing, feed liquid weight ratio is 1:10, and heating-up temperature is 40 DEG C, and heat time heating time is 3h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract respectively; (4) extracting honeysuckle water extract 4 parts, Galla Chinensis ethanol extraction 7 parts, Radix Notoginseng ethanol extraction 10 parts, Fructus Rosae Laevigatae ethyl acetate extract 2 parts, Radix Sophorae Tonkinensis ethyl acetate extract 4 parts, Tween-60 are 9 parts respectively by weight, Si Ban-40 is 3 parts, glycerol is 4 parts, sodium carboxymethyl cellulose is 10 parts, water is 250 parts, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
Embodiment 3
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, and feed liquid weight ratio is 1:4, heating-up temperature is 70 DEG C, heat time heating time is 3h, after extraction, extracting solution is centrifugal, discards precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains honeysuckle aqueous extract and Galla Chinensis water extract respectively; (2), after being pulverized with pulverizer by Radix Notoginseng, carry out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, heating-up temperature is 50 DEG C, and heat time heating time is 4h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction; (3) by after Fructus Rosae Laevigatae and Radix Sophorae Tonkinensis drying, carry out mechanical activation comminution again, stirring solvent extraction is carried out by ethyl acetate after pulverizing, feed liquid weight ratio is 1:10, and heating-up temperature is 40 DEG C, and heat time heating time is 3h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract respectively; (4) extracting honeysuckle water extract 8 parts, Galla Chinensis ethanol extraction 6 parts, Radix Notoginseng ethanol extraction 6 parts, Fructus Rosae Laevigatae ethyl acetate extract 4 parts, Radix Sophorae Tonkinensis ethyl acetate extract 5 parts, Tween-60 are 8 parts respectively by weight, Si Ban-40 is 5 parts, glycerol is 7 parts, sodium carboxymethyl cellulose is 6 parts, water is 280 parts, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
Embodiment 4
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, and feed liquid weight ratio is 1:4, heating-up temperature is 70 DEG C, heat time heating time is 3h, after extraction, extracting solution is centrifugal, discards precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains honeysuckle aqueous extract and Galla Chinensis water extract respectively; (2), after being pulverized with pulverizer by Radix Notoginseng, carry out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, heating-up temperature is 50 DEG C, and heat time heating time is 4h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction; (3) by after Fructus Rosae Laevigatae and Radix Sophorae Tonkinensis drying, carry out mechanical activation comminution again, stirring solvent extraction is carried out by ethyl acetate after pulverizing, feed liquid weight ratio is 1:10, and heating-up temperature is 40 DEG C, and heat time heating time is 3h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract respectively; (4) extracting honeysuckle water extract 5 parts, Galla Chinensis ethanol extraction 4 parts, Radix Notoginseng ethanol extraction 9 parts, Fructus Rosae Laevigatae ethyl acetate extract 3 parts, Radix Sophorae Tonkinensis ethyl acetate extract 6 parts, Tween-60 are 6 parts respectively by weight, Si Ban-40 is 4 parts, glycerol is 5 parts, sodium carboxymethyl cellulose is 9 parts, water is 330 parts, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
Embodiment 5
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, and feed liquid weight ratio is 1:4, heating-up temperature is 70 DEG C, heat time heating time is 3h, after extraction, extracting solution is centrifugal, discards precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains honeysuckle aqueous extract and Galla Chinensis water extract respectively; (2), after being pulverized with pulverizer by Radix Notoginseng, carry out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, heating-up temperature is 50 DEG C, and heat time heating time is 4h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction; (3) by after Fructus Rosae Laevigatae and Radix Sophorae Tonkinensis drying, carry out mechanical activation comminution again, stirring solvent extraction is carried out by ethyl acetate after pulverizing, feed liquid weight ratio is 1:10, and heating-up temperature is 40 DEG C, and heat time heating time is 3h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract respectively; (4) extracting honeysuckle water extract 7 parts, Galla Chinensis ethanol extraction 5 parts, Radix Notoginseng ethanol extraction 8 parts, Fructus Rosae Laevigatae ethyl acetate extract 3 parts, Radix Sophorae Tonkinensis ethyl acetate extract 6 parts, Tween-60 are 7 parts respectively by weight, Si Ban-40 is 5 parts, glycerol is 6 parts, sodium carboxymethyl cellulose is 8 parts, water is 310 parts, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
Comparative example 1
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, and feed liquid weight ratio is 1:4, heating-up temperature is 70 DEG C, heat time heating time is 3h, after extraction, extracting solution is centrifugal, discards precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains honeysuckle aqueous extract and Galla Chinensis water extract respectively; (2), after being pulverized with pulverizer by Radix Notoginseng, carry out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, heating-up temperature is 50 DEG C, and heat time heating time is 4h, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction; (3) extracting honeysuckle water extract 10 parts, Galla Chinensis ethanol extraction 3 parts, Radix Notoginseng ethanol extraction 5 parts, Tween-60 are 4 parts respectively by weight, Si Ban-40 is 6 parts, glycerol is 8 parts, sodium carboxymethyl cellulose is 5 parts, water is 350 parts, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
The patient of gingival hemorrhage is divided into 6 groups, and often organizing number is 15 people, respectively every day embodiment and the collutory of comparative example gargle, each 30mL, sooner or later each once, the cycle is one week.Whether also have gingival hemorrhage situation produce, gingiva still hemorrhage number is as follows if after one week, observing patient:
| Gingival hemorrhage number | The no longer hemorrhage number of gingiva | |
| Embodiment 1 | 8 | 7 |
| Embodiment 2 | 7 | 8 |
| Embodiment 3 | 5 | 10 |
| Embodiment 4 | 4 | 11 |
| Embodiment 5 | 1 | 14 |
| Comparative example 1 | 10 | 5 |
Claims (8)
1. prevent and treat a Chinese medicine mouth wash for gingival hemorrhage, it is characterized in that the Chinese medicine mouth wash of described control gingival hemorrhage comprises following composition by weight:
Honeysuckle aqueous extract 4-10 part,
Galla Chinensis ethanol extraction 3-7 part,
Radix Notoginseng ethanol extraction 5-10 part,
Fructus Rosae Laevigatae ethyl acetate extract 2-5 part,
Radix Sophorae Tonkinensis ethyl acetate extract 4-7 part,
Tween-60 4-9 part,
Si Ban-40 3-6 part,
Glycerol 4-8 part,
Sodium carboxymethyl cellulose 5-10 part,
Water 250-350 part.
2. a kind of Chinese medicine mouth wash preventing and treating gingival hemorrhage according to claim 1, is characterized in that the Chinese medicine mouth wash of described control gingival hemorrhage comprises following composition by weight:
Honeysuckle aqueous extract 5-8 part,
Galla Chinensis ethanol extraction 4-6 part,
Radix Notoginseng ethanol extraction 6-9 part,
Fructus Rosae Laevigatae ethyl acetate extract 3-4 part,
Radix Sophorae Tonkinensis ethyl acetate extract 5-6 part,
Tween-60 6-8 part,
Si Ban-40 4-5 part,
Glycerol 5-7 part,
Sodium carboxymethyl cellulose 6-9 part,
Water 280-330 part.
3. a kind of Chinese medicine mouth wash preventing and treating gingival hemorrhage according to claim 1, is characterized in that the Chinese medicine mouth wash of described control gingival hemorrhage comprises following composition by weight:
Honeysuckle aqueous extract 7 parts,
Galla Chinensis ethanol extraction 5 parts,
Radix Notoginseng ethanol extraction 8 parts,
Fructus Rosae Laevigatae ethyl acetate extract 3 parts,
Radix Sophorae Tonkinensis ethyl acetate extract 6 parts,
Tween-60 7 parts,
Si Ban-40 5 parts,
Glycerol 6 parts,
Sodium carboxymethyl cellulose 8 parts,
310 parts, water.
4. prevent and treat a preparation method for the Chinese medicine mouth wash of gingival hemorrhage, it is characterized in that, the preparation method of described Chinese medicine mouth wash comprises the following steps:
(1) difference extracting honeysuckle and Galla Chinensis, pulverize with pulverizer, be crushed to after becoming powder, Flos Lonicerae and Chinese Gall deionized water are carried out heated and stirred extraction, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain honeysuckle aqueous extract and Galla Chinensis water extract respectively;
(2), after being pulverized with pulverizer by Radix Notoginseng, stirring solvent extraction is carried out with ethanol, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtain Radix Notoginseng ethanol extraction;
(3) by after Fructus Rosae Laevigatae and Radix Sophorae Tonkinensis drying, carry out mechanical activation comminution again, stirring solvent extraction is carried out by ethyl acetate after pulverizing, after extraction, extracting solution is centrifugal, discard precipitation, clear liquid is carried out vacuum concentration, after concentrated, obtains Fructus Rosae Laevigatae ethyl acetate extract and Radix Sophorae Tonkinensis ethyl acetate extract respectively;
(4) extracting honeysuckle water extract 4-10 part, Galla Chinensis ethanol extraction 3-7 part, Radix Notoginseng ethanol extraction 5-10 part, Fructus Rosae Laevigatae ethyl acetate extract 2-5 part, Radix Sophorae Tonkinensis ethyl acetate extract 4-7 part, Tween-60 are 4-9 part respectively by weight, Si Ban-40 is 3-6 part, glycerol is 4-8 part, sodium carboxymethyl cellulose is 5-10 part, water is 250-350 part, be stirred to evenly, for preventing and treating the Chinese medicine mouth wash of gingival hemorrhage.
5. a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage according to claim 4, it is characterized in that, in step (1), Flos Lonicerae and Chinese Gall deionized water are carried out feed liquid weight ratio when heated and stirred is extracted and be 1:4, heating-up temperature is 70 DEG C, and heat time heating time is 3h.
6. a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage according to claim 4, it is characterized in that, after Radix Notoginseng being pulverized with pulverizer in step (2), when carrying out stirring solvent extraction with ethanol, feed liquid weight ratio is 1:6, heating-up temperature is 50 DEG C, and heat time heating time is 4h.
7. a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage according to claim 4, it is characterized in that, the feed liquid weight ratio that the middle Fructus Rosae Laevigatae of step (3) and Radix Sophorae Tonkinensis ethyl acetate carry out stirring solvent extraction is 1:10, and heating-up temperature is 40 DEG C, and heat time heating time is 3h.
8. a kind of preparation method of preventing and treating the Chinese medicine mouth wash of gingival hemorrhage according to claim 4, is characterized in that, in step (4), speed of agitator is 50rpm-200rpm.
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| CN113143832A (en) * | 2021-04-29 | 2021-07-23 | 湖南中医药大学第一附属医院((中医临床研究所)) | Gargle and preparation method thereof |
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Application publication date: 20150701 |