CN114028327A

CN114028327A - Oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride and preparation and use methods thereof

Info

Publication number: CN114028327A
Application number: CN202111604119.6A
Authority: CN
Inventors: 许力心; 孙慧; 蔡飞翔; 齐迎珍; 魏雪倩
Original assignee: Xiling Zhenjiang Medical Technology Co ltd
Current assignee: Xiling Zhenjiang Medical Technology Co ltd
Priority date: 2021-12-24
Filing date: 2021-12-24
Publication date: 2022-02-11
Anticipated expiration: 2041-12-24
Also published as: CN114028327B

Abstract

The invention discloses a traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride for oral cavity and a preparation method and a use method thereof, wherein the effective components of the antibacterial gel comprise baicalin extract, honeysuckle extract, pseudo-ginseng extract, ectoin and strontium chloride; and the components by mass percentage are as follows: 1-3% of ectoin, 1-5% of strontium chloride, 1-5% of baicalin extract, 1-7% of honeysuckle extract, 1-5% of pseudo-ginseng extract, 0.5-1% of carbomer and the balance of deionized water. The Chinese herbal medicine composition mainly contains the Chinese herbal medicine components, does not contain any antibiotic component, does not cause drug resistance of periodontitis bacteria, and has no side effect on human bodies; the antibacterial gel promotes alveolar bone injury repair by adding the ectoin and the strontium chloride, reduces osteoblast injury and simultaneously promotes osteoblast activity under the synergistic effect of the ectoin and the strontium chloride, achieves the purposes of promoting alveolar bone injury repair, reducing cell injury and inflammatory reaction and preventing tooth sensitivity, and has good application value.

Description

Oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride and preparation and use methods thereof

Technical Field

The invention relates to an oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride and a preparation method and a use method thereof.

Background

People eat the food as the day and eat the teeth as the first in a common way, and along with the improvement of the living standard of people, the oral hygiene and health are more and more emphasized. Plaque and harmful substances in the plaque accumulated on the gingival-tooth joint part act on gingiva for a long time to cause inflammation, and the plaque accumulation and the inflammation of the gingiva are aggravated by the existence of tartar, bad restoration bodies, food impaction, tooth dislocation crowding, mouth respiration and the like to cause gingivitis. If the gingivitis cannot be timely treated, inflammation can be deeply diffused to periodontal ligament, alveolar bone and cementum from the gingiva to develop into periodontitis, the periodontal ligament is damaged due to the expansion of the inflammation, the alveolar bone is gradually absorbed, the gingiva is separated from the tooth root, the gingival sulcus is deepened to form a periodontal pocket, periodontal tissues are damaged, particularly when the absorption of the alveolar bone is aggravated, the phenomena of insufficient tooth strength, tooth loosening, tooth displacement and the like occur, and periodontal abscess can be formed when the body resistance is reduced and the drainage of periodontal pocket seepage is not smooth. In addition, when a patient carries out corresponding oral treatment such as scaling, periodontal surgery and the like, oral microorganisms widely exist in dental plaque, oral mucosa, dental calculus, gingival pocket, saliva and dental pulp after surgery, and easily enter a wound to cause dental plaque and bacterial infection, so oral bacteriostatic nursing is particularly important.

At present, oral care gel products in the market mostly achieve the antibacterial and anti-inflammatory effects by adding antibiotic drugs such as nitrozole, imidazole derivatives, tetracyclines and the like. For example, the dental implant oral care gel disclosed in chinese patent document CN110856702A inhibits dental plaque by adding imidazoline, and reduces postoperative infection; another chinese patent document CN111358770A discloses a method for synthesizing a gel patch preparation for treating periodontitis by adding metronidazole to kill porphyromonas gingivalis, prevotella intermedia, and the like. These methods can effectively kill the bacteria in periodontitis, but the bacteria in periodontitis can easily generate antibiotic resistance after long-term use of the products, and corresponding side effects can be generated on human bodies. Furthermore, none of these products can repair alveolar bone, which is damaged when periodontal pockets are formed as described above, and although existing oral care gel products can kill periodontitis bacteria, alveolar bone damage still exists and oral microorganisms widely exist, periodontitis is again initiated when body resistance is reduced, and gingivitis is repeated and not completely cured.

Disclosure of Invention

Aiming at the problems, the invention provides the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride and the use method thereof. The specific technical scheme is as follows:

firstly, the invention provides an oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, and the effective components of the antibacterial gel comprise baicalin extract, honeysuckle extract, pseudo-ginseng extract, ectoin and strontium chloride.

The oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride comprises the following components in percentage by mass: 1-3% of ectoin, 1-5% of strontium chloride, 1-5% of baicalin extract, 1-7% of honeysuckle extract, 1-5% of pseudo-ginseng extract, 0.5-1% of carbomer and the balance of deionized water.

Preferably, the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride comprises the following components in percentage by mass: the preferable content of the ectoine is 1-2%, the preferable content of the strontium chloride is 1-2%, the preferable content of the scutellaria baicalensis is 2-3%, the preferable content of the honeysuckle is 2-5%, the preferable content of the panax notoginseng is 2-3%, and the preferable content of the carbomer is 0.5-0.7%.

Secondly, the invention provides a preparation method of the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, which comprises the following steps:

1) preparing a traditional Chinese medicine extract: preparing baicalin extract, honeysuckle extract and pseudo-ginseng extract respectively according to requirements for later use;

2) preparing an effective component A: weighing the prepared baicalin extract, honeysuckle extract and pseudo-ginseng extract according to the weight percentage, and stirring in a proper amount of deionized water until the baicalin extract, the honeysuckle extract and the pseudo-ginseng extract are completely dissolved to obtain an effective component A for later use;

3) preparing an effective component B: weighing the ectoin and the strontium chloride according to the weight percentage, and stirring the ectoin and the strontium chloride in a proper amount of deionized water until the ectoin and the strontium chloride are completely dissolved to obtain an effective component B for later use;

4) preparation of carbomer swell: weighing carbomer raw materials according to the weight percentage, dissolving the carbomer raw materials in the balance of deionized water, and adding a certain amount of NaOH to adjust the pH to 6-8 to obtain carbomer swelling substances for later use;

5) preparing bacteriostatic gel: firstly, adding the prepared effective component A into the prepared carbomer swelling substance, stirring until gel is formed, then adding the prepared effective component B, and uniformly mixing to obtain the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride.

As a preferable technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, in the step 1), the preparation method of the baicalin extract comprises the following steps: removing fibrous roots and silt from the dried roots of scutellaria baicalensis, removing coarse bark, crushing, putting the raw materials into a tank, boiling and decocting the raw materials for 2 hours by 10 times of boiling water for the first time, adding 8 times of water for decocting for the second time and the third time respectively, decocting for 1 hour each time, combining the decoction liquids, concentrating to a proper amount, adjusting the pH value to 1.0-2.0 by using hydrochloric acid, preserving heat at 80 ℃, standing, filtering to obtain a precipitate, washing with water until the pH value is about 5.0, then washing with 70% ethanol until the pH value is about 7.0, drying at low temperature, volatilizing the ethanol, and drying under reduced pressure to obtain a finished product of the baicalin extract.

As a preferable technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, in step 1), the preparation method of the honeysuckle extract comprises the following steps: cutting dried flos Lonicerae, decocting with 10 times of water for 2 hr, filtering, decocting with 8 times of water for 2 hr, filtering, mixing filtrates, concentrating under reduced pressure, and drying the concentrated solution under reduced pressure to obtain flos Lonicerae extract.

As a preferable technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, in step 1), the preparation method of the panax notoginseng extract comprises the following steps: crushing dried pseudo-ginseng roots, adding 5-8 times of 70% ethanol for leaching for 2-3 hours, collecting filtrate, carrying out reduced pressure concentration treatment to obtain concentrated solution, and carrying out spray drying to obtain the pseudo-ginseng extract.

In a preferable technical scheme, in the step 2), the stirring time for preparing the effective component A is 1-2 hours.

In a preferable technical scheme, in the step 3), the stirring time for preparing the effective component B is 20-30 min.

In addition, the invention also provides a use method of the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, which specifically comprises the following steps: injecting the antibacterial gel coating into periodontal pocket of gingival sulcus treatment region after conventional periodontal treatment to wrap teeth until overflowing slightly; no food, no water and no mouth wash are needed within 30 minutes; the preparation is administered once daily for 7 days as a treatment course.

The invention has the beneficial effects that:

(1) the bacteriostatic gel mainly contains Chinese herbal medicine components, does not contain any antibiotic component, does not cause drug resistance of periodontitis bacteria, and has no side effect on human bodies.

(2) The antibacterial gel promotes alveolar bone injury repair by adding the ectoine and the strontium chloride, wherein the ectoine can form a protective layer around cells to effectively reduce cell injury and protect osteoblasts, and the strontium chloride can promote the activity of osteoblasts and increase the proliferation of osteoblasts.

(3) The antibacterial gel disclosed by the invention achieves the effects of inhibiting bacteria, diminishing inflammation, preventing and treating post-swelling and pain by adding the baicalin extract and the honeysuckle extract; the notoginseng extract is added to help the gum stop bleeding and accelerate the healing of mucous membrane; the method combines the effects of ectoin and strontium chloride on promoting the repair of alveolar bone injury, achieves the aim of one-step treatment and repair, and solves the problem that periodontitis is difficult to cure repeatedly.

(4) The preparation method of the bacteriostatic gel provided by the invention concentrates the baicalin extract to improve the bactericidal and bacteriostatic effects; the concentrated solution of the honeysuckle extract is dried under reduced pressure, so that the pharmacological active ingredients such as chlorogenic acid, luteolin glycoside and the like are retained to the maximum extent, and the inhibition of the concentrated solution on periodontitis bacteria is ensured; spray drying the concentrated solution of Notoginseng radix extract to ensure the activity of saponins, polysaccharides, flavonoids, alkynes, alcohols, etc., and ensure that it can induce platelets to release hemostatic active substances such as ADP, platelet factor and Ca2+, etc., and promote blood coagulation and oral mucosa repair.

(5) According to the preparation method of the antibacterial gel, the ectoin, the strontium chloride and the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract are prepared separately and then added into the carbomer swelling material in sequence, so that the strontium salt is effectively prevented from reacting with flavonoid and other ingredients in the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract, and the problem that the effective ingredients cannot be uniformly dispersed and dissolved due to the fact that the effective ingredients are directly mixed with carbomer is solved.

(6) The antibacterial gel prepared by the invention has wide application range, not only can be suitable for antibacterial and anti-inflammatory corresponding oral treatment such as scaling, periodontal surgery and the like, but also can be suitable for relieving the tooth sensitivity problem after tooth washing, tooth whitening and the like.

Drawings

FIG. 1 shows the observation of various indexes before the application of the bacteriostatic gel;

FIG. 2 shows the observation of each index of the bacteriostatic gel after being applied for 3 days;

FIG. 3 shows the results of 7-day observation of various indexes of the bacteriostatic gel.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the embodiments.

Example 1

The embodiment is to prepare a traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride for oral cavity, and the antibacterial gel comprises the following components in percentage by mass: 3% of ectoin, 4% of strontium chloride, 2% of baicalin extract, 2% of honeysuckle extract, 1% of pseudo-ginseng extract, 1% of carbomer and the balance of deionized water. The preparation method comprises the following specific steps:

1) preparing a traditional Chinese medicine extract: preparing baicalin extract, honeysuckle extract and pseudo-ginseng extract respectively according to requirements for later use. Wherein the content of the first and second substances,

the preparation method of the baicalin extract comprises the following steps: removing fibrous roots and silt from the dried roots of scutellaria baicalensis, removing coarse bark, crushing, putting the raw materials into a tank, boiling and decocting the raw materials for 2 hours by 10 times of boiling water for the first time, adding 8 times of water for decocting for the second time and the third time respectively, decocting for 1 hour each time, combining the decoction liquids, concentrating to a proper amount, adjusting the pH value to 1.0-2.0 by using hydrochloric acid, preserving heat at 80 ℃, standing, filtering to obtain a precipitate, washing with water until the pH value is about 5.0, then washing with 70% ethanol until the pH value is about 7.0, drying at low temperature, volatilizing the ethanol, and drying under reduced pressure to obtain a finished product of the baicalin extract.

The preparation method of the honeysuckle extract comprises the following steps: cutting dried flos Lonicerae, decocting with 10 times of water for 2 hr, filtering, decocting with 8 times of water for 2 hr, filtering, mixing filtrates, concentrating under reduced pressure, and drying the concentrated solution under reduced pressure to obtain flos Lonicerae extract.

The preparation method of the pseudo-ginseng extract comprises the following steps: crushing dried pseudo-ginseng roots, adding 5-8 times of 70% ethanol for leaching for 2-3 hours, collecting filtrate, carrying out reduced pressure concentration treatment to obtain concentrated solution, and carrying out spray drying to obtain the pseudo-ginseng extract.

2) Preparing an effective component A: dissolving the prepared baicalin extract, honeysuckle extract and pseudo-ginseng extract in a proper amount of deionized water according to the weight percentage, and stirring for 1-2 hours until the extracts are completely dissolved to obtain an effective component A for later use.

3) Preparing an effective component B: weighing the ectoin and the strontium chloride according to the weight percentage, dissolving the ectoin and the strontium chloride in a proper amount of deionized water, and stirring for 20-30 min until the ectoin and the strontium chloride are completely dissolved to obtain an effective component B for later use.

4) Preparation of carbomer swell: weighing carbomer raw materials according to the weight percentage, dissolving the carbomer raw materials in the residual deionized water, and adding a certain amount of NaOH to adjust the pH value to 6-8 to obtain carbomer swelling substances for later use, wherein white powder cannot be seen on the surface and white agglomerates cannot be seen in the solution.

Example 2

The embodiment also prepares a traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride for oral cavity, and the antibacterial gel comprises the following components in percentage by mass: 2% of ectoin, 2% of strontium chloride, 3% of baicalin, 5% of honeysuckle extract, 3% of pseudo-ginseng extract, 0.7% of carbomer and the balance of deionized water. The specific preparation method is the same as that of example 1.

Example 3

The embodiment also prepares a traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride for oral cavity, and the antibacterial gel comprises the following components in percentage by mass: 1% of ectoin, 1% of strontium chloride, 5% of baicalin, 7% of honeysuckle extract, 5% of pseudo-ginseng extract, 0.5% of carbomer and the balance of deionized water. The specific preparation method is the same as that of example 1.

Examples of effects

In order to verify the synergistic effect of the ectoin and the strontium chloride to promote the repair of alveolar bone injury, and the effects of inhibiting bacteria and diminishing inflammation of traditional Chinese medicine extract components, helping gum to stop bleeding and accelerating mucous membrane healing. In this example, the verification was performed in a comparative example, and the specific verification method was as follows:

first, this example provides three sets of comparative examples, and provides a blank control, wherein:

comparative example 1: the prepared traditional Chinese medicine antibacterial gel for the oral cavity comprises the following components in percentage by mass: 2% of baicalin, 2% of honeysuckle extract, 1% of pseudo-ginseng extract, 1% of carbomer and the balance of deionized water. The specific preparation method is the same as that of example 1.

Comparative example 2: the prepared traditional Chinese medicine antibacterial gel for the oral cavity comprises the following components in percentage by mass: 4% of strontium chloride, 2% of baicalin, 2% of honeysuckle extract, 1% of pseudo-ginseng extract, 1% of carbomer and the balance of deionized water. The specific preparation method is the same as that of example 1.

Comparative example 3: the prepared traditional Chinese medicine antibacterial gel for the oral cavity comprises the following components in percentage by mass: 3% of ectoin, 2% of baicalin, 2% of honeysuckle extract, 1% of pseudo-ginseng extract, 1% of carbomer and the balance of deionized water. The specific preparation method is the same as that of example 1.

The components and contents of the oral traditional Chinese medicine bacteriostatic gel prepared in each proportion, the comparative example and the example are shown in table 1.

TABLE 1 oral bacteriostatic gel product component contents used in each group

Components

Blank control group

Comparative example 1

Comparative example 2

Comparative example 3

Example 1

Example 2

Example 3

Ectoin

0

--

3％

2％

1％

Strontium chloride

0

--

4％

--

4％

2％

1％

Baicalin extract

0

2％

3％

5％

Honeysuckle extract

0

2％

7％

Notoginseng radix extract

0

1％

5％

Carbomer

0

1％

0.7％

0.5％

Deionized water

0

94％

90％

91％

87％

80.3％

80.5％

Physiological saline

100％

0

The experimental method comprises the following steps: in order to ensure the real effectiveness of the effect, 140 cases of adult periodontitis patients are selected as study objects in the experiment, and the age of the patients is as follows: the test group is 18-60 years old, and is randomly and averagely divided into an experimental group, a comparison group and a blank control group. The blank control group was subjected to conventional periodontal scaling and scaling, and was washed with normal saline after the operation. The experimental group was subjected to conventional periodontal scaling and scaling, and the antibacterial gel product for oral cavity prepared in examples 1 to 3 was applied after the operation, and the film was injected into the periodontal pocket in the gingival sulcus and the treatment area to wrap the teeth until the teeth were slightly overflowed. Within 30 minutes, no food, no water and no mouth wash. It is administered once daily. The comparative group was treated in exactly the same manner as the experimental group except that the antibacterial gel products for oral use prepared in comparative examples 1 to 3 were used. The component contents of the oral bacteriostatic gel product used in each group are shown in table 1. And respectively observing and counting the Gingival Index (GI), the plaque index (PLI), the gingival Sulcus Bleeding Index (SBI) and the Probing Depth (PD) of the patient before treatment, 3 days after treatment and 7 days after treatment.

The experimental results are as follows: the two groups of observation indexes before and after treatment are shown in table 2, table 3 and table 4 and figures 1 to 3.

TABLE 2 Observation of indices before administration

Index (I)

Blank control group

Control group

1

Control group 2

Control group 3

Experimental group 1

Experimental group 2

Experimental group 3

GI

1.93±0.27

1.92±0.35

1.93±0.24

1.95±0.37

1.95±0.55

1.92±0.53

1.95±0.52

PLI

2.11±0.15

2.08±0.29

2.10±0.11

2.05±0.20

2.02±0.31

2.06±0.37

2.10±0.11

SBI

3.08±0.30

3.14±0.25

3.20±0.35

3.05±0.31

3.17±0.47

3.29±0.37

3.10±0.35

PD

5.01±0.97

4.95±0.86

5.13±0.62

4.96±0.59

4.98±1.01

5.03±0.88

4.98±0.92

TABLE 3 observation index for 3 days after taking medicine

Index (I)

Blank control group

Control group

1

Control group 2

Control group 3

Experimental group 1

Experimental group 2

Experimental group 3

GI

1.61±0.39

1.12±0.33

1.09±0.52

1.11±0.38

1.02±0.34

1.12±0.55

1.05±0.39

PLI

1.76±0.39

1.25±0.31

1.17±0.35

1.20±0.36

1.13±0.19

1.16±0.42

1.10±0.53

SBI

1.97±0.51

1.44±0.35

1.41±0.40

1.45±0.53

1.40±0.36

1.42±0.34

1.46±0.38

PD

4.62±0.93

4.65±0.71

4.50±0.51

4.54±0.50

4.33±0.91

4.35±0.70

4.38±0.62

TABLE 4 7 days of drug administration

Index (I)

Blank control group

Control group

1

Control group 2

Control group 3

Experimental group 1

Experimental group 2

Experimental group 3

GI

0.98±0.62

0.65±0.37

0.58±0.21

0.62±0.35

0.53±0.52

0.59±0.41

0.65±0.48

PLI

1.13±0.39

0.88±0.26

0.84±0.31

0.85±0.20

0.79±0.28

0.86±0.33

0.83±0.42

SBI

0.70±0.48

0.31±0.29

0.27±0.33

0.30±0.51

0.28±0.29

0.31±0.54

0.30±0.41

PD

4.31±0.90

4.32±0.53

4.10±0.71

4.16±0.64

3.87±0.89

3.90±0.58

3.88±0.67

The observation indexes of the experimental group and the control group are processed by SPSS software, and are statistically processed by t test, and the two groups have significant difference P less than 0.05. Test results show that the antibacterial gel for the oral cavity can achieve better clinical effect when being applied to adjuvant therapy of periodontitis, and can effectively inhibit bacteria, diminish inflammation and stop bleeding and recover.

Meanwhile, fig. 1 to 3 also show that, compared with the recovery conditions of the blank control group and the control group before and after the drug administration for 3 days, the indexes of GI, PLI and SBI of the control group are obviously superior to those of the blank control group, which indicates that the traditional Chinese medicine extract in the oral bacteriostatic gel can achieve the effects of inhibiting bacteria, diminishing inflammation, helping gum hemostasis and accelerating mucosa healing. Compared with the recovery conditions of the control group and the experimental group before and 7 days after the administration, the PD index of the experimental group is smaller than that of the control group, which shows that under the synergistic effect of the ectoin and the strontium chloride, the alveolar bone injury repair can be promoted to a certain extent.

Generally, the bacteriostatic gel disclosed by the invention mainly contains Chinese herbal medicine components, does not contain any antibiotic component, does not cause drug resistance of periodontitis bacteria, and has no side effect on human bodies. The antibacterial gel promotes alveolar bone injury repair by adding the ectoine and the strontium chloride, wherein the ectoine can form a protective layer around cells to effectively reduce cell injury and protect osteoblasts, and the strontium chloride can promote the activity of osteoblasts and increase the proliferation of osteoblasts. The antibacterial gel disclosed by the invention achieves the effects of inhibiting bacteria, diminishing inflammation, preventing and treating post-swelling and pain by adding the baicalin extract and the honeysuckle extract; the notoginseng extract is added to help the gum stop bleeding and accelerate the healing of mucous membrane; the method combines the effects of ectoin and strontium chloride on promoting the repair of alveolar bone injury, achieves the aim of one-step treatment and repair, and solves the problem that periodontitis is difficult to cure repeatedly. The preparation method of the bacteriostatic gel provided by the invention concentrates the baicalin extract to improve the bactericidal and bacteriostatic effects; the concentrated solution of the honeysuckle extract is dried under reduced pressure, so that the pharmacological active ingredients such as chlorogenic acid, luteolin glycoside and the like are retained to the maximum extent, and the inhibition of the concentrated solution on periodontitis bacteria is ensured; spray drying the concentrated solution of Notoginseng radix extract to ensure the activity of saponins, polysaccharides, flavonoids, alkynes, alcohols, etc., and ensure that it can induce platelets to release hemostatic active substances such as ADP, platelet factor and Ca2+, and promote blood coagulation and oral mucosa repair. According to the preparation method of the antibacterial gel, the ectoin, the strontium chloride and the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract are prepared separately and then added into the carbomer swelling material in sequence, so that the strontium salt is effectively prevented from reacting with flavonoid and other ingredients in the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract, and the problem that the effective ingredients cannot be uniformly dispersed and dissolved due to the fact that the effective ingredients are directly mixed with carbomer is solved. The antibacterial gel prepared by the invention has wide application range, can be suitable for antibacterial and anti-inflammatory corresponding oral treatment such as scaling, periodontal surgery and the like, can also be suitable for relieving the problem of tooth sensitivity after tooth washing, tooth whitening and the like, and has good application value.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive. Furthermore, it should be understood that although the present specification describes embodiments, this does not include only one embodiment, and such description is for clarity only, and those skilled in the art should be able to make the specification as a whole, and the embodiments may be appropriately combined to form other embodiments understood by those skilled in the art.

Claims

1. An oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride is characterized in that: the effective components of the antibacterial gel comprise baicalin extract, honeysuckle extract, pseudo-ginseng extract, ectoin and strontium chloride.

2. The oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to claim 1, which is characterized in that: the antibacterial gel comprises the following components in percentage by mass: 1-3% of ectoin, 1-5% of strontium chloride, 1-5% of baicalin extract, 1-7% of honeysuckle extract, 1-5% of pseudo-ginseng extract, 0.5-1% of carbomer and the balance of deionized water.

3. The oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to claim 2, which is characterized in that: the antibacterial gel comprises the following components in percentage by mass: the preferable content of the ectoine is 1-2%, the preferable content of the strontium chloride is 1-2%, the preferable content of the scutellaria baicalensis is 2-3%, the preferable content of the honeysuckle is 2-5%, the preferable content of the panax notoginseng is 2-3%, and the preferable content of the carbomer is 0.5-0.7%.

4. A method for preparing the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to any one of claims 1 to 3, which is characterized in that: the method comprises the following steps:

5. The method for preparing the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to claim 4, is characterized in that: in the step 1), the preparation method of the baicalin extract comprises the following steps: removing fibrous roots and silt from the dried roots of scutellaria baicalensis, removing coarse bark, crushing, putting the raw materials into a tank, boiling and decocting the raw materials for 2 hours by 10 times of boiling water for the first time, adding 8 times of water for decocting for the second time and the third time respectively, decocting for 1 hour each time, combining the decoction liquids, concentrating to a proper amount, adjusting the pH value to 1.0-2.0 by using hydrochloric acid, preserving heat at 80 ℃, standing, filtering to obtain a precipitate, washing with water until the pH value is about 5.0, then washing with 70% ethanol until the pH value is about 7.0, drying at low temperature, volatilizing the ethanol, and drying under reduced pressure to obtain a finished product of the baicalin extract.

6. The method for preparing the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to claim 4, is characterized in that: in the step 1), the preparation method of the honeysuckle extract comprises the following steps: cutting dried flos Lonicerae, decocting with 10 times of water for 2 hr, filtering, decocting with 8 times of water for 2 hr, filtering, mixing filtrates, concentrating under reduced pressure, and drying the concentrated solution under reduced pressure to obtain flos Lonicerae extract.

7. The method for preparing the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to claim 4, is characterized in that: in the step 1), the preparation method of the pseudo-ginseng extract comprises the following steps: crushing dried pseudo-ginseng roots, adding 5-8 times of 70% ethanol for leaching for 2-3 hours, collecting filtrate, carrying out reduced pressure concentration treatment to obtain concentrated solution, and carrying out spray drying to obtain the pseudo-ginseng extract.

8. The method for preparing the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to claim 4, is characterized in that: in the step 2), the stirring time for preparing the effective component A is 1-2 h.

9. The method for preparing the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to claim 4, is characterized in that: in the step 3), the stirring time for preparing the effective component B is 20-30 min.

10. A method for using the oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride according to any one of claims 1-3, which is characterized in that: injecting the antibacterial gel coating into periodontal pocket of gingival sulcus treatment region after conventional periodontal treatment to wrap teeth until overflowing slightly; no food, no water and no mouth wash are needed within 30 minutes; the preparation is administered once daily for 7 days as a treatment course.