CN104840967A - Taste correction method for oral liquid preparation of traditional Chinese medicine containing ethyl alcohol - Google Patents
Taste correction method for oral liquid preparation of traditional Chinese medicine containing ethyl alcohol Download PDFInfo
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- CN104840967A CN104840967A CN201510241278.2A CN201510241278A CN104840967A CN 104840967 A CN104840967 A CN 104840967A CN 201510241278 A CN201510241278 A CN 201510241278A CN 104840967 A CN104840967 A CN 104840967A
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Abstract
The invention disclose a taste correction method for oral liquid preparation of traditional Chinese medicine containing ethyl alcohol, and the taste correction method comprises the following steps of adding an auxiliary material used for correcting taste into the oral liquid preparation of traditional Chinese medicine containing ethyl alcohol, dissolving and mixing evenly. The taste correction method provided by the invention can eventually achieve the purpose that the needs of different groups can be met and the bad taste of the oral liquid preparation of traditional Chinese medicine containing ethyl alcohol can be corrected. The taste correction method has the advantages that the operation is simple, the application is wide, the product taste is significantly improved, and the method is suitable for industrialized production, can ensure the different needs of different groups on medicine taste, meet the needs of special populations on taste correction agent, and the products are suitable for old people, children, and diabetes.
Description
Technical field
The present invention relates to a kind of method to modify taste of oral preparation of Chinese traditional medicinal, particularly relate to a kind of method to modify taste containing ethanol Chinese medicinal liquor oral formulations.
Background technology
Mouthfeel difference is one of inherent shortcoming of oral preparation of Chinese traditional medicinal, is also the biggest obstacle affecting patient consumes's compliance.Chinese medicine taste masking research conventional means is that dosage form changes, certain formulations technique changes and add correctives, and wherein adding correctives is the method to modify taste that technology is the simplest, cost is most economical, the good results are evident.There is now a lot of listing and have employed the lifting that the method for adding correctives carries out mouthfeel grinding herbal species.
For conventional dosage form as tablet, pill, granule, oral liquid etc., method to modify taste is fairly simple, less on the impact of sample after adding correctives; But the method to modify taste containing ethanol Chinese medicinal liquor oral formulations is comparatively complicated, difficulty is very big, mainly be: the ethanol of high concentration brings stronger zest, and after being combined with the bitter taste of Chinese medicine ingredients and the special penetrating odor of Chinese medicine, patient is reduced greatly to the drug compliance containing ethanol Chinese medicine preparation, easily the determinant attributes such as the clarity of product are impacted adding of correctives simultaneously.Literature search shows, and there is no pertinent literature or patent report the method at present both at home and abroad.
Therefore, the method to modify taste containing ethanol Chinese medicinal liquor oral formulations of a kind of practicality of research and development is needed badly.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of method to modify taste containing ethanol Chinese medicinal liquor oral formulations of novel practical, the method can for providing taste masking technical scheme containing ethanol Chinese medicinal liquor oral formulations, its mouthfeel is obtained significantly improve, improve the drug compliance of patient.
For solving the problems of the technologies described above, a kind of novel method to modify taste containing ethanol Chinese medicinal liquor oral formulations of the present invention, comprises the steps:
Adjuvant for taste masking adds in the Chinese medicinal liquor oral formulations containing ethanol, dissolves, mix homogeneously.
As preferred technical scheme, preparation Chinese medicine used comprises animal tcm, plant medicine and animals and plants mixing Chinese medicine, and preparation type comprises medicated wine and tincture, and ethanol content is 10%-70%.
As preferred technical scheme, the described adjuvant for taste masking, upset the correctives of human body taste and smell organ to the perception of the taste of medicine own or abnormal smells from the patient by self taste and abnormal smells from the patient, comprise sweeting agent, bitter tasting retarding agent and aromatic three major types, this three classes taste masking adjuvant can be used in combination, wherein sweeting agent plays the Main Function of taste masking, can be used alone, and all the other two kinds of correctivess of also can arranging in pairs or groups are used in combination.The described adjuvant for taste masking is containing pharmaceutic adjuvant and the food additive in ethanol Chinese medicinal liquor oral formulations with good solubility; Wherein two or more preferably in saccharin sodium, sucralose, aspartame, neotame, acesulfame potassium of sweeting agent; One or more preferably in glycerol, propylene glycol of bitter tasting retarding agent; One or more preferably in mint aroma essence, lemon flavor essence, Fructus Jujubae flavor essence, Fructus Fortunellae Margaritae flavor essence, osmanthus flower fragrant essence, Cortex Cinnamomi flavor essence, vanillin, geraniol and citral of aromatic, this three classes taste masking adjuvant can be used in combination.The described adjuvant for taste masking is dissolved in containing in ethanol Chinese medicinal liquor oral formulations, dissolves and mixed method comprises ultrasonic, jolting and stirring.The described adjuvant for taste masking is dissolved in containing in ethanol Chinese medicinal liquor oral formulations, in sweeting agent, bitter tasting retarding agent and aromatic three major types, of a sortly adds without sequencing, can add simultaneously; If use the correctives of different large class, sweeting agent and bitter tasting retarding agent first add, and the link of the preparation process flow process added comprises extraction, mixing, leaves standstill, and adds after aromatic, and its link added comprises mixing, leaves standstill.
The sweeting agent of high sugariness multiple is used alone and improves poor effect to the mouthfeel containing ethanol Chinese medicinal liquor oral formulations, and 2 kinds or sweeting agent of more than two kinds use simultaneously and effectively can suppress its zest, convergence bitterness, reduce the bitterness residence time in the oral cavity.Use with sweeting agent, bitter tasting retarding agent effectively can assist the diffusion in the oral cavity of convergence bitterness, and shortens the persistent period of bitterness simultaneously.The use of aromatic can increase the fragrance of liquid preparation, covers bad smell, helps out to improving taste.
The proportioning of the described adjuvant for taste masking be study by experiment effect be improved on the mouthfeel of medicine, do not affect curative effect of medication, do not affect the clarity of liquid preparation, consumption when not affecting drug safety.
As preferred technical scheme, the gross mass of described correctives accounts for the 0.5%-15% containing ethanol Chinese medicinal liquor oral formulations gross mass; Or the cumulative volume of the described adjuvant for taste masking accounts for the 0.5%-15% containing ethanol Chinese medicinal liquor oral formulations cumulative volume.
As preferred technical scheme, describedly comprise liquid preparation prepared by Chinese medicine extract containing ethanol Chinese medicinal liquor oral formulations, particularly include prepared by one or more Chinese medicine extract following containing ethanol liquid preparation: Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Calyx Seu Fructus Physalis, Fructus Gardeniae, Radix Achyranthis Bidentatae, Rhizoma Paridis, Fructus Forsythiae, Radix Isatidis, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Andrographis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Picrorhizae, Herba Artemisiae Annuae, Rhizoma Belamcandae, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Rhizoma Polygoni Cuspidati, Fructus Aurantii, Pericarpium Citri Reticulatae, Fructus Chaenomelis, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae, Rhizoma Sparganii, Borneolum Syntheticum, Rhizoma Et Radix Notopterygii, Radix Polygalae, Radix Ginseng, Leptoradix Ginseng, Cortex Periplocae, Radix Clematidis, the Radix Aucklandiae, Herba Asari, Cortex Acanthopancis, Spica Prunellae, Herba Leonuri, Camphora, Fructus Foeniculi, Cortex Cinnamomi, Rhizoma Atractylodis, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Caulis Spatholobi, Caulis Trachelospermi, Radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, Agkistrodon, Pheretima.
The present invention, by the interpolation of different correctives, effectively suppresses its bitterness and penetrating odor, significantly can improve the mouthfeel containing ethanol Chinese medicinal liquor oral formulations, be widely used, simple to operate, is applicable to suitability for industrialized production.
Sweeting agent used in the present invention is not by the high sugariness multiple sweeting agent (being commonly called as " health sugar ") of body metabolism, sugariness adjustable magnification saves, mouthfeel type can be allocated as requested, ensure that different crowd needs the difference of preparation mouthfeel, mouthfeel is good, be widely used, meet the requirement of special population to correctives, product is particularly suitable for old man, child, has the patient of diabetes to take.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1 osteodynia spirit tincture
Original prescription forms: Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 80g, Rhizoma Zingiberis 110g, Sanguis Draxonis 1g, Olibanum 5g, Myrrha 5g, Borneolum Syntheticum 1.5g.
Each medical material prepares 1000ml tincture according to the process of 2010 editions Chinese Pharmacopoeias.In manufacturing process, get sucralose 15g, in the percolate left standstill after joining mixing, leave standstill 48h, filter, filtrate water and ethanol are adjusted to 1000ml, to obtain final product.
In the present embodiment, the link that adds of sweeting agent is standing, can ensure the clarity of final products.The osteodynia spirit tincture prepared through the method enters sweet taste in the mouth, and zest is strong, the micro-hardship of entrance, and zest is residual strong, and patient's taking dose is constant.
The present embodiment is used alone a kind of sweeting agent, effectively cannot cover the zest of preparation entrance.
Embodiment 2 osteodynia spirit tincture
Original prescription forms: Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 80g, Rhizoma Zingiberis 110g, Sanguis Draxonis 1g, Olibanum 5g, Myrrha 5g, Borneolum Syntheticum 1.5g.
Each medical material prepares 1000ml tincture according to the process of 2010 editions Chinese Pharmacopoeias.In manufacturing process, get sucralose 7.5g, saccharin sodium 12.5g, vanillin 5g, in the percolate left standstill after joining mixing, leave standstill 48h, filter, filtrate water and ethanol are adjusted to 1000ml, to obtain final product.
In the present embodiment, the link that adds of sweeting agent and aromatic is standing, can ensure the clarity of final products.The osteodynia spirit tincture prepared through the method enters sweet taste in the mouth, and zest is weak, and gas is fragrant, and the micro-hardship of entrance, bitterness and zest remain weak, and patient's taking dose is constant.
Meet the pharmaceutic adjuvant of 2010 editions Chinese Pharmacopoeias and relevant food additive requirement for the adjuvant of taste masking in the present embodiment, significantly can improve the mouthfeel of tincture.
Investigate through stability test, after acceleration investigation June and room temperature place 18 months, adopt the clarity of the osteodynia of this method to modify taste spirit tincture to meet the requirements.
Embodiment 3 rheocamphoradin
Original prescription forms: Camphora 25g, Rhizoma Zingiberis 25g, Radix Et Rhizoma Rhei 20g, Fructus Foeniculi 10g, Cortex Cinnamomi 10g, Fructus Capsici 5g, Oleum Eucalypti 12.5ml.
Each medical material prepares 1000ml tincture according to the process of 2010 editions Chinese Pharmacopoeias.In production process, get sucralose 1g, acesulfame potassium 15g, geranial 4g, glycerol 120ml and lemon flavor essence 10ml, add in the percolate of collection, be stirred to dissolve, to obtain final product.
In the present embodiment, the link that adds of sweeting agent and aromatic is mixing, can ensure the clarity of final products.The rheocamphoradin prepared through the method enters sweet taste in the mouth, and zest is weak, and gas is fragrant, and the micro-hardship of entrance, bitterness and zest remain weak, and patient's taking dose is constant.
Meet the pharmaceutic adjuvant of 2010 editions Chinese Pharmacopoeias and relevant food additive requirement for the adjuvant of taste masking in the present embodiment, significantly can improve the mouthfeel of tincture.
Investigate through stability test, after acceleration investigation June and room temperature place 18 months, adopt the clarity of the rheocamphoradin of this method to modify taste to meet the requirements.
Embodiment 4 HUOXIANG ZHENGQI SHUI
Original prescription forms: Rhizoma Atractylodis 160g, Pericarpium Citri Reticulatae 160g, Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 160g, Radix Angelicae Dahuricae 240g, Poria 240g, Pericarpium Arecae 240g, Rhizoma Pinelliae 160g, Radix Glycyrrhizae extractum 20g, patchouli oil 1.6ml, Folium perillae acutae oil 0.8ml.
Each medical material prepares tincture 2050ml according to the process of 2010 editions Chinese Pharmacopoeias.In production process, get saccharin sodium 10g, neotame 1g joins in 60% alcohol dipping liquid, seepage pressure effects after dipping 24h; Separately get propylene glycol 70ml, hami melon flavor essence 15ml and citral 4g, join 7 taste herbal extracts and the mixed concentrated solution of Radix Glycyrrhizae extractum, stirring and evenly mixing together with the alcoholic solution of patchouli oil, Folium perillae acutae oil, ethanol content is adjusted in right amount with ethanol and water, and make full dose become 2050ml, leave standstill, filter, fill.
In the present embodiment, the link that adds of sweeting agent is extract, and the link that adds of aromatic is mixing, can ensure the clarity of final products.The ageratum water inlet prepared through the method is sweet, and zest is weak, and gas fragrance, the micro-hardship of entrance, bitterness and zest remain weak, and patient's taking dose is constant.
Meet the pharmaceutic adjuvant of 2010 editions Chinese Pharmacopoeias and relevant food additive requirement for the adjuvant of taste masking in the present embodiment, significantly can improve the mouthfeel of tincture.
Investigate through stability test, after acceleration investigation June and room temperature place 18 months, adopt the clarity of the HUOXIANG ZHENGQI SHUI of this method to modify taste to meet the requirements.
Embodiment 5 relaxing muscles and tendons rheumatism wine
Original prescription forms: Herba Alyxiae Sinensis 30g, Caulis Trachelospermi 30g, Caulis Spatholobi 30g, Radix seu Caulis Verntilaginis Leiocarpae 20g, Fructus Rhodomyrti 30g, Rhizoma Polygoni Cuspidati 10g, water Koryo 30g, kadsura root 20g, sucrose 85g.
Each medical material prepares medicated wine 1000ml according to the process of State Food and Drug Administration drug standard WS-10957 (ZD-0957)-2002-2012Z.In production process, get sucralose 1.5g, Aspartane 2.5g and mint aroma essence 1ml, with 8 taste herbal extracts stirring and evenly mixing together with sucrose simple syrup, add Chinese liquor to prescribed volume, mixing, filter, fill.
In the present embodiment, the link that adds of sweeting agent and aromatic is mixing, can ensure the clarity of final products.The relaxing muscles and tendons rheumatism wine prepared through the method enters sweet taste in the mouth, and zest is weak, and gas is pure and fresh, and the micro-hardship of entrance, bitterness and zest remain weak, and when patient uses, dosage is constant.
Meet the pharmaceutic adjuvant of 2010 editions Chinese Pharmacopoeias and relevant food additive requirement for the adjuvant of taste masking in the present embodiment, significantly can improve the mouthfeel of medicated wine.
Investigate through stability test, after acceleration investigation June and room temperature place 18 months, adopt the clarity of the relaxing muscles and tendons rheumatism wine of this method to modify taste to meet the requirements.
Embodiment 6 relaxing muscles and tendons rheumatism wine
Original prescription forms: Herba Alyxiae Sinensis 30g, Caulis Trachelospermi 30g, Caulis Spatholobi 30g, Radix seu Caulis Verntilaginis Leiocarpae 20g, Fructus Rhodomyrti 30g, Rhizoma Polygoni Cuspidati 10g, water Koryo 30g, kadsura root 20g, sucrose 85g.
Each medical material prepares medicated wine 1000ml according to the process of State Food and Drug Administration drug standard WS-10957 (ZD-0957)-2002-2012Z.In production process, get saccharin sodium 5g and acesulfame potassium 12.5g, with 8 taste herbal extracts stirring and evenly mixing together with sucrose simple syrup, add Chinese liquor to prescribed volume, mixing, filter, fill.
In the present embodiment, the link that adds of sweeting agent and aromatic is mixing, can ensure the clarity of final products.The relaxing muscles and tendons rheumatism wine prepared through the method enters sweet taste in the mouth, and zest is weak, and the micro-hardship of entrance, bitterness and zest remain weak, and when patient uses, dosage is constant.
Meet the pharmaceutic adjuvant of 2010 editions Chinese Pharmacopoeias and relevant food additive requirement for the adjuvant of taste masking in the present embodiment, significantly can improve the mouthfeel of medicated wine.
Investigate through stability test, after acceleration investigation June and room temperature place 18 months, adopt the clarity of the relaxing muscles and tendons rheumatism wine of this method to modify taste to meet the requirements.
Embodiment 7 Sanliangban Yaojiu
Original prescription forms: Radix Angelicae Sinensis 100g, Radix Astragali Preparata 100g, Radix Achyranthis Bidentatae 100g, Radix Saposhnikoviae 50g.
Each medical material prepares medicated wine 1000ml according to the technique of Drug Standard of Ministry of Public Health of the Peoples Republic of China WS3-B-0180-90.In production process, get saccharin sodium 5g, acesulfame potassium 15g and Fructus Jujubae flavor essence 10ml, join 4 taste medicines and extract in percolate, be stirred to dissolve rear leaving standstill, filter, to obtain final product.
In the present embodiment, the link that adds of sweeting agent and aromatic is mixing, can ensure the clarity of final products.The Sanliangban Yaojiu prepared through the method enters sweet taste in the mouth, and zest is weak, and gas is fragrant, and zest remains weak, and when patient uses, dosage is constant.
Meet the pharmaceutic adjuvant of 2010 editions Chinese Pharmacopoeias and relevant food additive requirement for the adjuvant of taste masking in the present embodiment, significantly can improve the mouthfeel of medicated wine.
Investigate through stability test, after acceleration investigation June and room temperature place 18 months, adopt the clarity of the Sanliangban Yaojiu of this method to modify taste to meet the requirements.
Claims (8)
1. containing a method to modify taste for ethanol Chinese medicinal liquor oral formulations, it is characterized in that: comprise the steps: to add in the Chinese medicinal liquor oral formulations containing ethanol for the adjuvant of taste masking, dissolve, mix homogeneously.
2. the method to modify taste containing ethanol Chinese medicinal liquor oral formulations as claimed in claim 1, it is characterized in that: the described Chinese medicine used containing ethanol Chinese medicinal liquor oral formulations comprises animal tcm, plant medicine and animals and plants mixing Chinese medicine, preparation type comprises medicated wine and tincture, and ethanol content is 10%-70%.
3. the method to modify taste containing ethanol Chinese medicinal liquor oral formulations as claimed in claim 1, it is characterized in that: the described adjuvant for taste masking, upset the correctives of human body taste and smell organ to the perception of the taste of medicine own or abnormal smells from the patient by self taste and abnormal smells from the patient, comprise sweeting agent, bitter tasting retarding agent and aromatic three major types, this three classes taste masking adjuvant can be used in combination; Wherein sweeting agent plays the Main Function of taste masking, can be used alone, and all the other two kinds of correctivess of also can arranging in pairs or groups are used in combination.
4. the method to modify taste containing ethanol Chinese medicinal liquor oral formulations as claimed in claim 3, is characterized in that: the described adjuvant for taste masking is containing pharmaceutic adjuvant and the food additive in ethanol Chinese medicinal liquor oral formulations with good solubility; Described sweeting agent be selected from saccharin sodium, sucralose, aspartame, neotame, acesulfame potassium two or more; Described bitter tasting retarding agent be selected from glycerol, propylene glycol one or more; Described aromatic be selected from mint aroma essence, lemon flavor essence, Fructus Jujubae flavor essence, Fructus Fortunellae Margaritae flavor essence, osmanthus flower fragrant essence, Cortex Cinnamomi flavor essence, vanillin, geraniol and citral one or more.
5. the method to modify taste containing ethanol Chinese medicinal liquor oral formulations as claimed in claim 1, is characterized in that: the described adjuvant for taste masking is dissolved in containing in ethanol Chinese medicinal liquor oral formulations, dissolves and mixed method comprises ultrasonic, jolting and stirring.
6. the method to modify taste containing ethanol Chinese medicinal liquor oral formulations as claimed in claim 1, it is characterized in that: the described adjuvant for taste masking is dissolved in containing in ethanol Chinese medicinal liquor oral formulations, in sweeting agent, bitter tasting retarding agent and aromatic three major types, of a sortly add without sequencing, namely add simultaneously; Between different large class, sweeting agent and bitter tasting retarding agent first add, and the link of the preparation process flow process added comprises extraction, mixing, leaves standstill, and adds after aromatic, and its link added comprises mixing, leaves standstill.
7. the method to modify taste containing ethanol Chinese medicinal liquor oral formulations as claimed in claim 4, is characterized in that: the gross mass of the described adjuvant for taste masking accounts for the 0.5%-15% containing ethanol Chinese medicinal liquor oral formulations gross mass; Or the cumulative volume of the described adjuvant for taste masking accounts for the 0.5%-15% containing ethanol Chinese medicinal liquor oral formulations cumulative volume.
8. the method to modify taste containing ethanol Chinese medicinal liquor oral formulations as claimed in claim 1, it is characterized in that: described containing ethanol Chinese medicinal liquor oral formulations be include prepared by one or more Chinese medicine extract following containing ethanol liquid preparation: Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Calyx Seu Fructus Physalis, Fructus Gardeniae, Radix Achyranthis Bidentatae, Rhizoma Paridis, Fructus Forsythiae, Radix Isatidis, Radix Sophorae Flavescentis, Herba Taraxaci, Herba Andrographis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Picrorhizae, Herba Artemisiae Annuae, Rhizoma Belamcandae, bitter Rhizoma Alpiniae Officinarum, Herba Erodii, Rhizoma Polygoni Cuspidati, Fructus Aurantii, Pericarpium Citri Reticulatae, Fructus Chaenomelis, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Cortex Cinnamomi, Rhizoma Cyperi, Rhizoma Curcumae, Rhizoma Sparganii, Borneolum Syntheticum, Rhizoma Et Radix Notopterygii, Radix Polygalae, Radix Ginseng, Leptoradix Ginseng, Cortex Periplocae, Radix Clematidis, the Radix Aucklandiae, Herba Asari, Cortex Acanthopancis, Spica Prunellae, Herba Leonuri, Camphora, Fructus Foeniculi, Cortex Cinnamomi, Rhizoma Atractylodis, the Rhizoma Pinelliae, Cortex Magnoliae Officinalis, Caulis Spatholobi, Caulis Trachelospermi, Radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, Agkistrodon, Pheretima.
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| CN112684093A (en) * | 2020-12-08 | 2021-04-20 | 广西中医药大学 | Quality detection method of eleven-prescription medicinal liquor |
| CN112684093B (en) * | 2020-12-08 | 2022-11-25 | 广西中医药大学 | Quality detection method of eleven-prescription medicinal liquor |
| CN113082131A (en) * | 2021-04-20 | 2021-07-09 | 高世芬 | Medicinal liquor with analgesic function and preparation method thereof |
| CN115068546B (en) * | 2022-06-02 | 2023-08-22 | 石家庄市九洲兽药有限公司 | Traditional Chinese veterinary medicine oral liquid for preventing and treating poultry liver diseases and application thereof |
| CN115068546A (en) * | 2022-06-02 | 2022-09-20 | 石家庄市九洲兽药有限公司 | Traditional Chinese veterinary medicine oral liquid for preventing and treating liver diseases of poultry and application thereof |
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Application publication date: 20150819 |