CN102416139B - Chinese medicine composition for treating breast diseases - Google Patents
Chinese medicine composition for treating breast diseases Download PDFInfo
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- CN102416139B CN102416139B CN 201010502296 CN201010502296A CN102416139B CN 102416139 B CN102416139 B CN 102416139B CN 201010502296 CN201010502296 CN 201010502296 CN 201010502296 A CN201010502296 A CN 201010502296A CN 102416139 B CN102416139 B CN 102416139B
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Abstract
The invention discloses a Chinese medicine composition for treating breast diseases, comprising the following ingredients: 90-110 weight portions of Chinese angelica, 80-100 weight portions of white peony root, 60-70 weight portions of cortex moutan, 50-70 weight portions of obcordateleaf raspberry root, 50-70 weight portions of rhizoma cyperi, 40-60 weight portions of Ligusticum wallichii, 40-60 weight portions of green tangerine peel, 40-60 weight portions of radix aucklandiae, 40-60 weight portions of radix curcumae, 40-60 weight portions of sparganium, 40-60 weight portions of rhizoma curcuma, 40-60 weight portions of immature bitter orange, 40-60 weight portions of radix paeoniae rubrathe, 40-60 weight portions of cistanche salsa, 40-60 weight portions of longspur epimedium, 30-50 weight portions of folium artemisiae argyi, 30-50 weight portions of rhizoma corydalis, 30-50 weight portions of peach seed, 10-30 weight portions of radix bupleuri, 10-30 weight portions of licorice, and 0.5-1.5 weight portions of saffron crocus. The Chinese medicine composition disclosed herein can be used for treating mammary gland hyperplasia and other breast diseases.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition that is used for the treatment of mastopathy.
Background technology
The existing innerwear Chinese medicine preparation kind that is used for the treatment of mastopathy is less, and Chinese patent application CN101099826A discloses a kind of Chinese medicinal tablet and preparation method thereof, and Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra are added alcohol reflux, extracting solution is condensed into thick paste, Pericarpium Trichosanthis, Herba Taraxaci, Rhizoma Bolbostematis, Radix Bupleuri decoct with water, and filtrate decompression is condensed into thick paste, mix with above-mentioned thick paste, stir, add the Rhizoma Corydalis fine powder, stir drying, be ground into fine powder, add starch, mixing, alcohol granulation, dry, add lubricant, mix homogeneously, tabletting, film coating, namely.Its Chinese medicinal tablet that makes has that preparation technology is simple, with low cost, easy to use, bioavailability is high, mouthfeel good, the advantage of taking convenience, can be used for treating depression of liver-QI, disease such as the cyclomastopathy due to the toxicity-stasis mutual resistance, mammitis.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition that is used for the treatment of mastopathy.
For achieving the above object, technical scheme of the present invention provides a kind of Chinese medicine composition that is used for the treatment of mastopathy, and its crude drug is: Radix Angelicae Sinensis 90-110 weight portion; Radix Paeoniae Alba 80-100 weight portion; Cortex Moutan 60-70 weight portion; Radix Rubi obcordati 50-70 weight portion; Rhizoma Cyperi 50-70 weight portion; Rhizoma Chuanxiong 40-60 weight portion; Pericarpium Citri Reticulatae Viride 40-60 weight portion; Radix Aucklandiae 40-60 weight portion; Radix Curcumae 40-60 weight portion; Rhizoma sparganic 40-60 weight portion; Rhizoma Curcumae 40-60 weight portion; Fructus Aurantii Immaturus 40-60 weight portion; Radix Paeoniae Rubra 40-60 weight portion; Herba Cistanches 40-60 weight portion; Herba Epimedii 40-60 weight portion; Folium Artemisiae Argyi 30-50 weight portion; Rhizoma Corydalis 30-50 weight portion; Semen Persicae 30-50 weight portion; Radix Bupleuri 10-30 weight portion; Radix Glycyrrhizae 10-30 weight portion; Stigma Croci 0.5-1.5 weight portion.
Chinese medicine composition of the present invention, preferred crude drug is: Radix Angelicae Sinensis 100 weight portions; The Radix Paeoniae Alba 90 weight portions; Cortex Moutan 65 weight portions; Radix Rubi obcordati 60 weight portions; Rhizoma Cyperi 60 weight portions; Rhizoma Chuanxiong 50 weight portions; Pericarpium Citri Reticulatae Viride 50 weight portions; The Radix Aucklandiae 50 weight portions; Radix Curcumae 50 weight portions; Rhizoma sparganic 50 weight portions; Rhizoma Curcumae 50 weight portions; Fructus Aurantii Immaturus 50 weight portions; Radix Paeoniae Rubra 50 weight portions; Herba Cistanches 50 weight portions; Herba Epimedii 50 weight portions; Folium Artemisiae Argyi 40 weight portions; Rhizoma Corydalis 40 weight portions; Semen Persicae 40 weight portions; Radix Bupleuri 20 weight portions; Radix Glycyrrhizae 20 weight portions; Stigma Croci 1 weight portion.
Chinese medicine composition of the present invention can be used for preparing the medicine of mastopathy such as treatment cyclomastopathy or acute mastitis disease.It can make clinical various dosage forms commonly used for above-mentioned Chinese medicine composition and any pharmaceutically acceptable carrier, as tablet, pill, capsule, granule, electuary, oral liquid, syrup, mixture or powder etc.Wherein preferred dosage form is oral liquid.Its clinical taking convenience, production technology is simple.
According to a preferred embodiment of the invention, the invention provides a kind of newborn recovery oral liquid Chinese patent medicine product, its preparation method is: above-mentioned 20 crude drug simply, and except Stigma Croci, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Aucklandiae, that Semen Persicae extracts volatile oil is standby, ten Six-elements such as the aqueous solution after medicinal residues and the distillation and all the other Radix Paeoniae Albas decoct with water 2 times, 2h for the first time, 1h for the second time, collecting decoction, filter, filtrate concentrates, and adds sodium benzoate, stirs evenly, leave standstill filtration, get filtrate, it is an amount of to add the Stigma Croci extracting solution, adds syrup, stir evenly, namely.
Technique scheme has following advantage:
The Chinese medicine composition that is used for the treatment of mastopathy provided by the invention has the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, hard masses softening and resolving, promoting blood circulation and breaking stagnation, regulating QI to relieve pain.Clinical mainly for treating mammary gland hypertrophy and acute mastitis disease.Have determined curative effect, instant effect, characteristics that cure rate is high.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: newborn recovery oral liquid
One, prescription
Radix Angelicae Sinensis 100g Radix Paeoniae Alba 90g Cortex Moutan 65g Radix Rubi obcordati 60g Rhizoma Cyperi 60g
Rhizoma Chuanxiong 50g Pericarpium Citri Reticulatae Viride 50g Radix Aucklandiae 50g Radix Curcumae 50g rhizoma sparganic 50g
Rhizoma Curcumae 50g Fructus Aurantii Immaturus 50g Radix Paeoniae Rubra 50g Herba Epimedii 50g Herba Cistanches 50g
Semen Persicae 40g Rhizoma Corydalis 40g Folium Artemisiae Argyi 40g Radix Glycyrrhizae 20g Radix Bupleuri 20g
Stigma Croci 1g
Two, method for making
20 simply, and except Stigma Croci, it is standby that Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Aucklandiae, Semen Persicae extract volatile oil, ten Six-elements such as the aqueous solution after medicinal residues and the distillation and all the other Radix Paeoniae Albas decoct with water 2 times, for the first time 2h, 1h for the second time, collecting decoction filters, and filtrate is concentrated in right amount, add sodium benzoate 3g, stir evenly, leave standstill filtration, get filtrate, it is an amount of to add the Stigma Croci extracting solution, adds simple syrup to 1000ml, stir evenly, namely.
Three, character
This product is brown liquid, bitter in the mouth.
Four, differentiate
(1) get this product 20ml, the jolting that adds diethyl ether is extracted 3 times, each 20ml, and water liquid is standby, merges ether solution, volatilizes, and residue adds ethyl acetate 1ml makes dissolving, as need testing solution.Other gets Radix Angelicae Sinensis control medicinal material, each 0.5g of Rhizoma Chuanxiong control medicinal material, the 15ml that adds diethyl ether respectively, and supersound process 5 minutes filters, and filtrate volatilizes, and it is dissolving, medical material solution in contrast that residue adds ethyl acetate 1ml.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2010 B) test, draw each 10 μ l of above-mentioned three kinds of solution, put respectively on same silica gel g thin-layer plate, be developing solvent with normal hexane-ethyl acetate (9: 1), launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph, show the fluorescence principal spot of same color.
(2) get the water liquid behind the ether extraction under the item of [discriminating] (1), extract 2 times with water saturated n-butyl alcohol jolting, each 20ml, merge n-butyl alcohol liquid, with the saturated water washing of n-butyl alcohol 2 times, each 20ml, n-butyl alcohol liquid evaporate to dryness, residue add ethanol 1ml makes dissolving, as need testing solution.Other gets the peoniflorin reference substance, adds ethanol and makes the solution that 1ml contains 2mg, in contrast product solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2010 B), draw each 5 μ l of above-mentioned two liquid, put respectively on same silica gel thin-layer plate, with chloroform-ethyl acetate-methanol-formic acid (40: 5: 10: 0.2) be developing solvent, launch, take out, dry, spray is with 5% Rhizoma et radix valerianae vinegar sulfuric acid solution, and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Five, check
Relative density: should be not less than 1.05 (an appendix VII of Chinese Pharmacopoeia version in 2010 A).
PH value: 3.5～5.5 (an appendix VII of Chinese Pharmacopoeia version in 2010 G).
Other: should meet every regulation relevant under the mixture item (an appendix I of Chinese Pharmacopoeia version in 2010 J).
Six, function cures mainly
Dispersing the stagnated live-QI to relieve the stagnation of QI, hard masses softening and resolving, promoting blood circulation and breaking stagnation, regulating QI to relieve pain.Mainly for treating mammary gland hypertrophy and acute mastitis disease.
Seven, usage and dosage
Adult every day three times, each 20ml, 20 days is a course for the treatment of, 5～7 days at interval.Continued for second course for the treatment of, but also continuous use.The woman patient is suitable for menstrual onset beginning in preceding 10～15 days medication.The careful usefulness of pregnant and lactate women.
Eight, specification
The 120ml/ bottle.Airtight preservation.
The clinical practice result of the oral liquid of test example 1: embodiment 1
1, clinical data is observed female patient 103 examples, average 32 years old altogether.The course for the treatment of the longest 15d, the shortest 3d.
2, Therapeutic Method and course of therapy group are oral with this product, each 10mL, and every day 3 times, 20 days was 1 course for the treatment of; The peaceful granule of matched group breast, boiled water is taken after mixing it with water, and each one bag, every day 3 times, 20 days was 1 course for the treatment of.The peaceful sources of particles of the breast that matched group adopts is from Chinese Pharmacopoeia peaceful granule of version breast in 2010, main component: Radix Bupleuri, Radix Angelicae Sinensis, Rhizoma Cyperi (processed with vinegar), Radix Salviae Miltiorrhizae, Radix Paeoniae Alba (parched), Semen Vaccariae, Radix Paeoniae Rubra, Rhizoma Atractylodis Macrocephalae (parched), Poria, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Herba Menthae.
3, criterion of therapeutical effect and result
3.1 criterion of therapeutical effect
Be indication with mastalgia, lump in breast.Produce effects: clinical symptom disappearance.Effectively: clinical symptoms is significantly improved, and attack times reduces; Invalid: symptom does not have change.
3.2 therapeutic outcome
The treatment group: mastalgia, lump in breast 103 examples, wherein cure 71 examples (68.93%), effective 25 examples (24.27%), invalid 7 examples (6.79%), total effective rate is 93.20%.
Matched group: mastalgia, lump in breast 103 examples, wherein cure 59 examples (57.28%), effective 18 examples (17.47%), invalid 26 examples (25.24%), total effective rate 74.75%.
Embodiment 2: RUKANG PIAN
Adopt following prescription, the aforesaid extraction step of preparation method is with embodiment 1, after with extract routinely formulation method make tablet.
Prescription:
Radix Angelicae Sinensis 90g Radix Paeoniae Alba 100g Cortex Moutan 60g Radix Rubi obcordati 70g Rhizoma Cyperi 50g
Rhizoma Chuanxiong 60g Pericarpium Citri Reticulatae Viride 40g Radix Aucklandiae 60g Radix Curcumae 40g rhizoma sparganic 60g
Rhizoma Curcumae 40g Fructus Aurantii Immaturus 60g Radix Paeoniae Rubra 40g Herba Epimedii 60g Herba Cistanches 40g
Semen Persicae 50g Rhizoma Corydalis 30g Folium Artemisiae Argyi 50g Radix Glycyrrhizae 10g Radix Bupleuri 30g
Stigma Croci 0.5g.
Embodiment 3: newborn recovering capsule
Adopt following prescription, the aforesaid extraction step of preparation method is with embodiment 1, after with extract after formulation method incapsulates routinely namely.
Prescription:
Radix Angelicae Sinensis 110g Radix Paeoniae Alba 80g Cortex Moutan 70g Radix Rubi obcordati 50g Rhizoma Cyperi 70g
Rhizoma Chuanxiong 40g Pericarpium Citri Reticulatae Viride 60g Radix Aucklandiae 40g Radix Curcumae 60g rhizoma sparganic 40g
Rhizoma Curcumae 60g Fructus Aurantii Immaturus 40g Radix Paeoniae Rubra 60g Herba Epimedii 40g Herba Cistanches 60g
Semen Persicae 30g Rhizoma Corydalis 50g Folium Artemisiae Argyi 30g Radix Glycyrrhizae 30g Radix Bupleuri 10g
Stigma Croci 1.5g.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (8)
1. a Chinese medicine composition that is used for the treatment of cyclomastopathy and acute mastitis disease is characterized in that, is formed by following feedstock production: Radix Angelicae Sinensis 90-110 weight portion; Radix Paeoniae Alba 80-100 weight portion; Cortex Moutan 60-70 weight portion; Radix Rubi obcordati 50-70 weight portion; Rhizoma Cyperi 50-70 weight portion; Rhizoma Chuanxiong 40-60 weight portion; Pericarpium Citri Reticulatae Viride 40-60 weight portion; Radix Aucklandiae 40-60 weight portion; Radix Curcumae 40-60 weight portion; Rhizoma sparganic 40-60 weight portion; Rhizoma Curcumae 40-60 weight portion; Fructus Aurantii Immaturus 40-60 weight portion; Radix Paeoniae Rubra 40-60 weight portion; Herba Cistanches 40-60 weight portion; Herba Epimedii 40-60 weight portion; Folium Artemisiae Argyi 30-50 weight portion; Rhizoma Corydalis 30-50 weight portion; Semen Persicae 30-50 weight portion; Radix Bupleuri 10-30 weight portion; Radix Glycyrrhizae 10-30 weight portion; Stigma Croci 0.5-1.5 weight portion.
2. Chinese medicine composition as claimed in claim 1 is characterized in that, is formed by following feedstock production: Radix Angelicae Sinensis 100 weight portions; The Radix Paeoniae Alba 90 weight portions; Cortex Moutan 65 weight portions; Radix Rubi obcordati 60 weight portions; Rhizoma Cyperi 60 weight portions; Rhizoma Chuanxiong 50 weight portions; Pericarpium Citri Reticulatae Viride 50 weight portions; The Radix Aucklandiae 50 weight portions; Radix Curcumae 50 weight portions; Rhizoma sparganic 50 weight portions; Rhizoma Curcumae 50 weight portions; Fructus Aurantii Immaturus 50 weight portions; Radix Paeoniae Rubra 50 weight portions; Herba Cistanches 50 weight portions; Herba Epimedii 50 weight portions; Folium Artemisiae Argyi 40 weight portions; Rhizoma Corydalis 40 weight portions; Semen Persicae 40 weight portions; Radix Bupleuri 20 weight portions; Radix Glycyrrhizae 20 weight portions; Stigma Croci 1 weight portion.
3. claim 1 or the 2 described Chinese medicine compositions application in the medicine of preparation treatment cyclomastopathy or acute mastitis disease.
4. a Chinese medicine preparation that is used for the treatment of cyclomastopathy and acute mastitis disease is characterized in that, comprises claim 1 or 2 described Chinese medicine compositions and pharmaceutically acceptable carrier.
5. Chinese medicine preparation as claimed in claim 4 is characterized in that, described preparation is acceptable tablet, pill, capsule, electuary, syrup, mixture or powder clinically.
6. Chinese medicine preparation as claimed in claim 5 is characterized in that, described electuary is granule.
7. Chinese medicine preparation as claimed in claim 5 is characterized in that, it is oral liquid.
8. the preparation method of the described Chinese medicine preparation of claim 7 is characterized in that, described 20 crude drug simply are except Stigma Croci, it is standby that Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Aucklandiae, Semen Persicae extract volatile oil, and ten Six-elements such as the aqueous solution after medicinal residues and the distillation and all the other Radix Paeoniae Albas decoct with water 2 times, the first time 2h, 1h for the second time, collecting decoction filters, filtrate concentrates, and adds sodium benzoate, stirs evenly, leave standstill filtration, get filtrate, it is an amount of to add the Stigma Croci extracting solution, add syrup, stir evenly, namely.
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| CN 201010502296 CN102416139B (en) | 2010-09-28 | 2010-09-28 | Chinese medicine composition for treating breast diseases |
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| CN102416139B true CN102416139B (en) | 2013-07-03 |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697984B (en) * | 2012-06-01 | 2014-08-06 | 薛冬梅 | Chinese medicinal external application preparation for treating acute mastitis |
| CN102755515B (en) * | 2012-06-27 | 2013-12-18 | 蔡爱宁 | Traditional Chinese medicine decoction for treating hyperplasia of mammary glands |
| CN103083476B (en) * | 2013-02-28 | 2014-08-20 | 董志敏 | Traditional Chinese medicine for treating acute mastitis |
| CN103446546B (en) * | 2013-09-18 | 2014-12-10 | 司继爱 | Capsule for eliminating illness and removing stasis and preparation method thereof |
| CN103705611A (en) * | 2014-01-06 | 2014-04-09 | 王国强 | Traditional Chinese medicine composition and capsule application thereof |
| CN104758821A (en) * | 2015-03-23 | 2015-07-08 | 周栋 | A capsule for treating hyperplasia of mammary glands and a preparing method thereof |
| CN105327069A (en) * | 2015-12-15 | 2016-02-17 | 无限极（中国）有限公司 | Formulation, preparation method and application of liver soothing traditional Chinese herbal medicine composition |
| CN105456992A (en) * | 2015-12-18 | 2016-04-06 | 青岛友诚高新技术有限公司 | Traditional Chinese medicinal composition for treating breast diseases and preparation method of traditional Chinese medicinal composition |
| CN105963461A (en) * | 2016-07-28 | 2016-09-28 | 王美千和 | Traditional Chinese medicine composition for treating mammary gland impassability and preparation method thereof |
| CN108671001A (en) * | 2018-05-21 | 2018-10-19 | 成都中医药大学华神药业有限责任公司 | A kind of charred FOLIUM ARTEMISIAE ARGYI and preparation method thereof, detection method |
| CN115998828B (en) * | 2022-07-04 | 2023-12-22 | 苏州市中医医院 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
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| CN1138472A (en) * | 1995-11-23 | 1996-12-25 | 李新民 | Presciption and prepn. technique of "Ruzengning", for treatment of hyperplasia of mammary glands |
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|---|---|---|---|---|
| CN1138472A (en) * | 1995-11-23 | 1996-12-25 | 李新民 | Presciption and prepn. technique of "Ruzengning", for treatment of hyperplasia of mammary glands |
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| 等.中药外敷并内服治疗乳腺增生80例.《中国中医急症》.2006,第15卷(第5期),546. * |
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