CN101199669A - Chinese medicine compound agent for treating female sperm quality lowclass - Google Patents
Chinese medicine compound agent for treating female sperm quality lowclass Download PDFInfo
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- CN101199669A CN101199669A CNA2006101301336A CN200610130133A CN101199669A CN 101199669 A CN101199669 A CN 101199669A CN A2006101301336 A CNA2006101301336 A CN A2006101301336A CN 200610130133 A CN200610130133 A CN 200610130133A CN 101199669 A CN101199669 A CN 101199669A
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- herba
- radix
- radix rehmanniae
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- 239000003814 drug Substances 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 title claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 claims abstract description 31
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 238000009472 formulation Methods 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 239000006187 pill Substances 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 210000000582 semen Anatomy 0.000 claims description 6
- 241000005787 Cistanche Species 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 9
- 239000008187 granular material Substances 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 208000007466 Male Infertility Diseases 0.000 abstract description 2
- 241000411851 herbal medicine Species 0.000 abstract description 2
- 235000008216 herbs Nutrition 0.000 abstract 2
- 241000336315 Cistanche salsa Species 0.000 abstract 1
- 241000804384 Cynomorium songaricum Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241000208688 Eucommia Species 0.000 abstract 1
- 241000096284 Gynochthodes officinalis Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 241000221013 Viscum album Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- -1 troches Substances 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 description 6
- 230000036512 infertility Effects 0.000 description 6
- 231100000535 infertility Toxicity 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 230000035935 pregnancy Effects 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 206010003883 azoospermia Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000019100 sperm motility Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 241000756943 Codonopsis Species 0.000 description 1
- 241001550206 Colla Species 0.000 description 1
- 241000209020 Cornus Species 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 206010021929 Infertility male Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese herbal compound preparation for treating inferior quality of male sperms, belonging to the drug preparations containing traditional herbs or the medical preparation extracted from plants. The invention is prepared by the raw materials of Herba Epimedii, Morinda officinalis, Cistanche salsa, salted Eucommia Bark, Viscum album, Himalayan Teasel Root, Dodder Seed, Cynomorium songaricum, Barbary Wolfberry Fruit, Radix Rehmanniae and Radix Rehmanniae Preparata. After twice water decoction, the decoction of all the herbs is mixed, filtered and concentrated into clear paste with 1.2 relative concentration under 50 DEG C; the clear paste is finally prepared into needed preparation formulations under the conventional Chinese herbal medicine preparation technology, such as pills, troches, capsules, granules and oral liquid. The invention which is used for treating male infertility can help improve the quality of male sperms, increase the number of sperms and strength the activity of sperms.
Description
Technical field
The present invention relates to contain the pharmaceutical preparation from traditional herbal medicines, or derive from the pharmaceutical product of plant, specifically is a kind of low compound Chinese medicinal preparation of mankind spermatozoon quality for the treatment of.
Background technology
At present, because the aggravation of social competition, the male is faced with increasing operating pressure.Add increasing environmental pollution again, more influence sperm generation and sophisticated chemical substance and absorbed by the male that cause the spermatiferous quantity of male to descend, the activity of sperm reduces through various approach.Occur increasing in the society because the infertility that male aspect reason causes.Yet Chinese medicine has original advantage aspect the mankind spermatozoon quality improving, and by the adjustment of Chinese medicine, improves the quality of sperm, can improve pregnancy rate greatly.
Chinese patent 1327817 discloses a kind of " pregnancy promoting medicine of treatment male endocrine infertility and preparation method thereof ", it is the medicament of being made by the following weight proportion raw material: 10～15 parts of Semen Cuscutae, 4.5～10 parts of Radix Achyranthis Bidentataes, 5～12 parts of Semen Plantaginiss, 6～15 parts of Fructus Lycii, 3～6 parts of Fructus Schisandrae Chinensis, 3～10 parts of Fructus Rubies, 10～30 parts of Rhizoma Polygonatis, 3～10 parts of Ramulus Cinnamomi, 3～15 parts of Herba Epimedii, 6～12 parts of Colla cornus cervis, 9～30 parts of Radix Astragali, 9～15 parts of Radix Codonopsis, 4.5～12 parts of Radix Angelicae Sinensis, 3～10 parts of Rhizoma Curculiginises, 2～10 parts of grades of Radix Glycyrrhizae, 15 flavor Chinese crude drugs.Medicine of the present invention shows to have the effect and the effect of the kidney warming replenishing essence, benefiting vital QI and blood through clinical use, mainly is adapted to male's azoospermia, azoospermia, essence and dyssecretosis infertility within dysspermatism and the cacospermia such as coagulates.
Summary of the invention
The present invention is exactly to descend in order to solve the spermatiferous quantity of male, the problem that the activity of sperm reduces, and a kind of patient's needs that can satisfy are provided, the low compound Chinese medicinal preparation of treatment mankind spermatozoon quality.
The present invention is achieved through the following technical solutions.
A kind of low compound Chinese medicinal preparation of mankind spermatozoon quality for the treatment of is characterized in that said preparation made by following raw materials in weight portion:
Herba Epimedii 30-50 part, Radix Morindae Officinalis 30-50 part, Herba Cistanches 30-50 part,
Cortex Eucommiae(processed with salt) 30-50 part, Herba Taxilli 30-50 part, Radix Dipsaci 30-50 part,
Semen Cuscutae 50-70 part, Herba Cynomorii 30-50 part, Fructus Lycii 50-70 part,
Radix Rehmanniae 30-50 part, Radix Rehmanniae Preparata 30-50 part;
Take by weighing above raw material and boil through 10 times of amounts, 2 decoctings of 8 times of amounts, collecting decoction filters, and is concentrated into the clear paste of 50 ℃ of relative densities 1.2, adopts Chinese medicine conventional formulation technology, is prepared into required dosage form.
Technique effect of the present invention:
The low compound Chinese medicinal preparation of treatment mankind spermatozoon quality of the present invention proves that through animal experiment, clinical practice it can improve the quality of sperm, and sperm quantity is increased, and spermatozoon activity strengthens, and can improve pregnancy rate greatly, is used for the treatment of male sterility.
The specific embodiment
Below in conjunction with embodiment compound Chinese medicinal preparation of the present invention is done concrete description.
In the following embodiments, used raw material is commercially available pharmaceutical grade.Specification is an example with the granule of 10g/ bag, but the also similar approach preparation of other preparation.
Take by weighing Herba Epimedii 40g, Radix Morindae Officinalis 40g, Herba Cistanches 40g, Cortex Eucommiae(processed with salt) 40g, Herba Taxilli 40g,
Radix Dipsaci 40g, Semen Cuscutae 60g, Herba Cynomorii 40g, Fructus Lycii 60g, Radix Rehmanniae 40g, Radix Rehmanniae Preparata 40g;
Above-mentioned raw materials decocts with water twice, 10 times of water gagings for the first time, and 8 times of water gagings decocted 2 hours for the first time for the second time, decocted 1 hour for the second time, and collecting decoction filters, and filtrate is concentrated into the clear paste of relative density 1.2 (50 ℃); The ratio that adds two parts of dextrin in a clear paste adds dextrin, and with 75% ethanol wet granulation, 60 ℃ of oven dry, granulate is made the about 1000g of granule, is distributed into the 10g/ bag, promptly.
Test of pesticide effectiveness result:
Said preparation is to male rat sperm count, sperm motility rate experimental study result: irritate stomach with Radix Tripterygii Wilfordii decocting liquid and cause rat sperm count, motility rate to reduce, investigate the effect of improving of said preparation, two week of medication the back detect sperm qualities, then by putting into female Mus at 1: 1, after becoming pregnant, detect the tire subnumber.The results are shown in Table 1.
Table 1 male rat sperm count, sperm motility rate experimental study result
Annotate: * and normal group be P＜0.01 relatively,
△Compare P＜0.01 with model group, visible said preparation can obviously improve the situation of the poor sperm quality that causes because of Radix Tripterygii Wilfordii, makes sperm quality and pregnancy rate return to normal level.
Said preparation sees Table 2 to the negative conversion rate experimental result of AsAb infertility rabbit.
Table 2 said preparation is to the negative conversion rate experimental result of AsAb infertility rabbit
In view of there are substantial connection in immune infertility and the AsAb positive, said preparation can make the positive model of rabbit AsAb turn out cloudy rapidly, and effect is obvious.
Said preparation was once treated low the inferior of 714 routine sperm qualities that Clinical detection goes out, and be 21-35 days the course of treatment, and the patient's sperm concentration more than 98%, motility rate etc. return to normal level.
Embodiment 2:
Prescription is with embodiment 1, and extraction process is with embodiment 1, but preparation process is a concentrated pill.Raw material decocts with water twice in the prescription, for the first time 10 times of water gagings, 8 times of water gagings for the second time, decocted 2 hours for the first time, decocted 1 hour for the second time, collecting decoction filters, filtrate is concentrated into the clear paste of relative density 1.2 (50 ℃), add starch 100g, mix 60 ℃ of oven dry, be ground into fine powder, adjusting total amount with starch is 200g.A small amount of 75% ethanol of spray makes it moistening in general ball pot, and a small amount of said mixture of spreading rotates general ball pot, brushes the powder that the wall of cooking adheres to, and sieve is got the granule between the 30-40 order, as parent nucleus.On parent nucleus, add 75% alcohol dampening repeatedly, dusting, round as a ball, sieve is got the piller between the 10-14 order, dries in the shade, and the qualified back of quality examination is with Aluminum-plastic composite bag packing, 2.0g/ bag.The said preparation taking convenience has remedied the deficiency that preparation must be taken after mixing it with water among the embodiment 1, can be easily with water delivery service or buccal.
The present invention can adopt general process of Chinese medicine preparation and device fabrication.Adopt Chinese medicine conventional formulation technology, be prepared into dosage forms such as pill, tablet, capsule, electuary, oral liquid.
Should illustrate that the present invention of said components preparation also can adopt the method for ethanol extraction except that water extraction.Or a part of water extraction, blended method behind another part ethanol extraction.Or the blended method of the water of a part of raw material or organic solvent extract and all the other raw material fine powders.
Claims (3)
1. treat the low compound Chinese medicinal preparation of mankind spermatozoon quality for one kind, it is characterized in that said preparation made by following raw materials in weight portion:
Herba Epimedii 30-50 part, Radix Morindae Officinalis 30-50 part, Herba Cistanches 30-50 part,
Cortex Eucommiae(processed with salt) 30-50 part, Herba Taxilli 30-50 part, Radix Dipsaci 30-50 part,
Semen Cuscutae 50-70 part, Herba Cynomorii 30-50 part, Fructus Lycii 50-70 part,
Radix Rehmanniae 30-50 part, Radix Rehmanniae Preparata 30-50 part;
Take by weighing above raw material and boil through 10 times of amounts, 2 decoctings of 8 times of amounts, collecting decoction filters, and is concentrated into the clear paste of 50 ℃ of relative densities 1.2, adopts Chinese medicine conventional formulation technology, is prepared into required dosage form.
2. according to the described compound Chinese medicinal preparation of claim 1, it is characterized in that said preparation is made by following raw materials in weight portion:
40 parts of Herba Epimedii, 40 parts of Radix Morindae Officinaliss, 40 parts of Herba Cistanches,
40 parts of Cortex Eucommiae(processed with salt), 40 parts of Herba Taxillis, 40 parts of Radix Dipsacis,
60 parts of Semen Cuscutae, 40 parts of Herba Cynomoriis, 60 parts of Fructus Lycii,
40 parts in the Radix Rehmanniae, 40 parts in Radix Rehmanniae Preparata.
3. duplicate agent according to the described Chinese medicine of claim 1, it is characterized in that described required dosage form is to adopt Chinese medicine conventional formulation technology to be prepared into pill, tablet, capsule, electuary, oral liquid etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101301336A CN101199669A (en) | 2006-12-13 | 2006-12-13 | Chinese medicine compound agent for treating female sperm quality lowclass |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101301336A CN101199669A (en) | 2006-12-13 | 2006-12-13 | Chinese medicine compound agent for treating female sperm quality lowclass |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101199669A true CN101199669A (en) | 2008-06-18 |
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ID=39515151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101301336A Pending CN101199669A (en) | 2006-12-13 | 2006-12-13 | Chinese medicine compound agent for treating female sperm quality lowclass |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101199669A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491639B (en) * | 2009-03-09 | 2011-04-13 | 张定法 | Traditional Chinese medicine for treating poor sperm quality due to spermophlebectasia |
| CN103156191A (en) * | 2013-03-18 | 2013-06-19 | 陈树杰 | A health food for promoting male testosterone secretion |
| CN103250851A (en) * | 2013-02-24 | 2013-08-21 | 沈根林 | Traditional Chinese medicine kidney invigorating preserved fruit sausage |
| CN106177789A (en) * | 2016-08-29 | 2016-12-07 | 徐焕柱 | A kind of Chinese medicine preparation treating male sterility |
-
2006
- 2006-12-13 CN CNA2006101301336A patent/CN101199669A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491639B (en) * | 2009-03-09 | 2011-04-13 | 张定法 | Traditional Chinese medicine for treating poor sperm quality due to spermophlebectasia |
| CN103250851A (en) * | 2013-02-24 | 2013-08-21 | 沈根林 | Traditional Chinese medicine kidney invigorating preserved fruit sausage |
| CN103156191A (en) * | 2013-03-18 | 2013-06-19 | 陈树杰 | A health food for promoting male testosterone secretion |
| CN103156191B (en) * | 2013-03-18 | 2013-12-11 | 陈树杰 | Health food for promoting male testosterone secretion |
| CN106177789A (en) * | 2016-08-29 | 2016-12-07 | 徐焕柱 | A kind of Chinese medicine preparation treating male sterility |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080618 |