CN104147394B - A kind of dendrobium candidum compound preparation and preparation method thereof - Google Patents
A kind of dendrobium candidum compound preparation and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of dendrobium candidum compound preparation, its preparation method, and its application in the medicine or health products that promote sleep is prepared.It by dendrobium candidum, rhizoma Gastrodiae is principal component that compound preparation disclosed by the invention, which is, the medicinal materials such as the seed of Oriental arborvitae, spina date seed, the vine of multiflower knotweed, fruit of Chinese wolfberry composition is equipped with, pulvis, extract is made or is equipped with the preparation that pharmaceutically acceptable auxiliary material or complementary composition are prepared.Dendrobium candidum compound preparation of the present invention can effectively facilitate sleep, improve sleep state, strengthen immunity is curative for effect, without it is additive, without accordance with tolerance, have no toxic side effect.
Description
Technical field：
The invention belongs to field of medicine preparing technology.Specifically the present invention relates to dendrobium candidum compound preparation and its preparation
Method.
Background technology：
Sleep-disorder or even insomnia are a kind of common diseases of Modern human populations, are that the length of one's sleep or sleep quality are unsatisfactory for
And influence a kind of subjective experience of routine work life.Sleep-disorder has transience, also have it is long-term, with social rhythm plus
It hurry up, stress increase, the incidence of disease of sleep-disorder is in steeply rise trend.Long-term sleep-disorder can influence the brain work(of people
Energy and blood pressure are, it is necessary to medicine conditioning and health care intervention.Meanwhile the immunity slept for human body also has very important work
With research shows, sleep deprivation person, and its internal NK cell value significantly reduces, immunity degradation；Extended sleep obstacle crowd, its
Immunity is generally relatively low.The medicine of currently used treatment sleep-disorder predominantly synthesizes chemicals, such as Benzodiazepines town
Quiet hypnotic, this kind of medicine have certain additive and side effect, still there is some limitations for prolonged application.And treatment by Chinese herbs
For sleep-disorder because its composition is various, action target spot is multiple, it is low with respect to toxic side effect the characteristics of be increasingly valued by the people recently.
Dendrobium candidum medicinal history is long,《Chinese Pharmacopoeia》The one record dendrobium candidum reinforcing stomach reg fluid of version in 2010, enriching yin
Heat-clearing.Rhizoma Gastrodiae is also a kind of rare Chinese medicine, has protection nerve cell, anticonvulsion, calm, the effect such as hypnosis.This two taste
Chinese medicine is all orchid family Common Medicinal Herbs, Papillary, is equipped with the medicinal materials such as the seed of Oriental arborvitae, spina date seed, the vine of multiflower knotweed, the fruit of Chinese wolfberry, function
Nourishing Yin and clearing heat, antitoxic heart-soothing and sedative, there is promoting sleeping, for treatment of sleep disorders and health-care assistance.Meanwhile dendrobium candidum,
Rhizoma Gastrodiae, matrimony vine etc. are rich in polysaccharide, have been demonstrated that body immunity can be strengthened, and compound uses, and can reach promotion improves sleep
To strengthen the effect of body immunity.
At present, the research and development on dendrobium candidum compound preparation are mainly increased using the immunity of Dendrobium officinale polysaccharide
Pretend and use, more with the compatible use such as American Ginseng, for strengthening body immunity, have no and slept using dendrobium candidum prescription from improvement
The compound preparation report of the further exciting human immunity enhancing of dormancy angle.
The content of the invention：
The technical problem to be solved in the present invention is to provide the compound based on a kind of dendrobium candidum and rhizoma Gastrodiae, the present invention
From sleep improvement angle, the effect of using dendrobium candidum enriching yin, with the use of this calming the liver to stop the wind Chinese medicine of tradition of rhizoma Gastrodiae, then
Plus the yin-nourishing spirit quieting medicine such as the seed of Oriental arborvitae, spina date seed, the vine of multiflower knotweed, fruit of Chinese wolfberry, improve and sleep with the lifting of exciting human immunity,
Simultaneously by dendrobium candidum, rhizoma Gastrodiae, LBP-X the effect of, reach inside and outside minor, strengthen the purpose of body immunity.The present invention
Carry out promoting sleep product development with dendrobium candidum prescription first, obtain effectively facilitating sleep, improve the health-care of immunity
Product.
In order to realize the above-mentioned purpose of the present invention, the invention provides following technical scheme：
A kind of dendrobium candidum compound preparation, the by weight percentage compound preparation are composed of the following components, and each component
Summation is equal to 100%,
A kind of dendrobium candidum compound preparation as mentioned, the compound preparation are directly to crush the powder formed by each component
Agent, or the extract that each component extracts to obtain via water or organic solvent, or by percentage by weight be 10%~90%
The pharmaceutical preparation that the extract of each component and 90%~10% excipient substance or complementary composition are prepared.
A kind of dendrobium candidum compound preparation as mentioned, the powdered extract of described dendrobium candidum each component extract are every
100 grams are more than 10 grams containing polysaccharide, and every 100 grams are more than 0.05 gram containing Gastrodin.
Application of the described compound preparation in the medicine for promoting sleep is prepared.
Application of the described compound preparation in the health products for promoting sleep are prepared.
Application of the described compound preparation in the health products for preparing strengthen immunity.
The preparation method of described compound preparation, this method comprise the steps：
A, dendrobium candidum, rhizoma Gastrodiae, the seed of Oriental arborvitae, spina date seed, the vine of multiflower knotweed, the fruit of Chinese wolfberry are directly beaten into powder and obtains powder；Or will be above-mentioned
Extracted after pulverizing medicinal materials with hot-water soak, compound extract medicinal extract is obtained after gained Aqueous extracts recycle-water；Or by above-mentioned pulverizing medicinal materials
Extracted afterwards with 20%~95% alcohol reflux, compound extract medicinal extract is obtained after gained extract solution recycling design；
B, compound medicinal powder obtained by a or extract medicinal extract are added into pharmaceutically acceptable auxiliary material or complementary composition system
It is standby into common dosage forms pharmaceutically.
A kind of dendrobium candidum compound preparation as mentioned, described pulvis refer to that medicine is more than 300 mesh super through being crushed to
Fine powder.
Dendrobium candidum compound preparation disclosed by the invention is by dendrobium candidum, rhizoma Gastrodiae, the seed of Oriental arborvitae, spina date seed, the vine of multiflower knotweed, Chinese holly
Matrimony vine forms, the pulvis being directly ground to by these medicinal materials using micropowder technology；Or extract what is obtained via water or organic solvent
Extract；Or prepared by percentage by weight for 10%~90% compound extract and 90%~10% auxiliary material or complementary composition
The pharmaceutical preparation formed.Wherein compound is configured to dendrobium candidum 10%~50%, rhizoma Gastrodiae 10%~50%, and the seed of Oriental arborvitae 5%~
30%th, spina date seed 5%~30%, the vine of multiflower knotweed 5%~30%, the fruit of Chinese wolfberry 5%~30%.Compound medicinal substances extract powdered extract is more
Sugared content is more than 10%, is more than 0.05% containing gastrodin content.
Pharmaceutical preparation of the present invention is oral pulvis, extract, granule, capsule, tablet, tincture, oral liquid.
Pharmaceutically acceptable carrier of the present invention refers to the conventional pharmaceutical carrier of pharmaceutical field, such as：Diluent, excipient such as water
Deng filler such as starch, sucrose etc.；Binder such as cellulose derivative, alginates, gelatin and polyvinylpyrrolidone；Moistening
Agent such as glycerine；Disintegrant such as agar, calcium carbonate and sodium acid carbonate；Sorbefacient such as quaternary ammonium compound；Surfactant such as ten
Six alkanols；Absorption carrier such as kaolin and soap clay；Lubricant such as talcum powder, calcium stearate and magnesium and with polyethylene glycol etc..
It can in addition contain add other assistant agents such as flavouring agent, sweetener etc. in the composition.
Dosage of the present invention is equivalent to polysaccharide 100~500mg/ times, Gastrodin aglycon 2~30mg/ times.
Compared with prior art or product, the invention has the advantages that：
1. major ingredient dendrobium candidum nourishing Yin and clearing heat used in product involved in the present invention, can effectively improve human body function,
Strengthen immunity, it is equipped with the tranquilizing and allaying excitement medicinal material such as rhizoma Gastrodiae, the seed of Oriental arborvitae, spina date seed, the vine of multiflower knotweed, fruit of Chinese wolfberry, and product active ingredient
Content is high, can effectively improve the human body state of mind, alleviates nervous and pressure, makes human body be easier to enter sleep state, obtain
To more preferable sleep quality, recover condition.
2. product preparation method involved in the present invention, it is not necessary to add any non-nutritive or functional additive, produce
When process using water is Extraction solvent, belong to all-natural product, it is safe and healthy, without because of side effect caused by foreign substance.
3. product preparation method involved in the present invention, simple and easy to do, production cost is low, and medicinal material used in compound preparation utilizes
Rate is high, good in economic efficiency.
4. technical process involved in the present invention discharges without sewage, waste gas, medicinal material slag can also do it again with (such as function is eaten
Product, feed etc.).
5. product purpose involved in the present invention is extensive, it can not only be used for intermediate and be used for opening for dendrobium candidum medicine series
Hair, can also be directly as health products human consumption.
Dendrobium candidum compound preparation of the present invention is made up of common Chinese medicine, and pertinent literature and forefathers' Research foundation show in these
Medicine toxic side effect is low, no teratogenesis, mutagenesis.
Embodiment：
The essentiality content of the present invention is further illustrated with embodiments of the invention below, but is not come in any way
The limitation present invention.
Embodiment 1：
Dendrobium candidum：150 grams；Rhizoma Gastrodiae：80 grams；The seed of Oriental arborvitae：60 grams；Spina date seed：100 grams；The vine of multiflower knotweed：60 grams；The fruit of Chinese wolfberry：
100 grams.The taste of the above 6, add water to cook secondary, 2 hours first times, second 1.5 hours, decocting liquid filtration, merge, concentration, must soak
204.1 grams of cream, recovery rate：38.51%.
Gained medicinal extract takes 10 grams, is dissolved with 50 milliliter of 40% ethanol, adds 5 grams of lactose, 2.5 grams of mannose, and solubility is formed sediment
80 grams of powder, with 20 mesh sieve hole wet granulations, shaping is dried, cross 20 mesh sieve holes and obtain 90 grams of particle.
Embodiment 2：
Dendrobium candidum：600 grams；Rhizoma Gastrodiae：300 grams；The seed of Oriental arborvitae：180 grams；Spina date seed：100 grams；The vine of multiflower knotweed：180 grams；Matrimony vine
Son：100 grams.
The taste herb powder of the above 6 is taken, is added water to cook secondary.Add the water of 12 times of amounts for the first time, decoct 3h；2nd 10 times of amounts
Water, decoct 2h, merge 2 decoction liquors, precipitate 24h, filtering, take filtrate, be concentrated under reduced pressure into relative density to 1.20~1.28
(60 DEG C), stirring the lower slow ethanol that adds makes alcohol content be 50%, cold heavy 24h, filtering, takes filtrate decompression concentration relative density extremely
Thick pastes more than 1.35 (80 DEG C), decompression drying, be ground into fine powder (cross 100 mesh sieves), take fine powder add recipe quantity propane diols with
PEG 400, mix, load capsule, produce capsule 1000, pack.
Embodiment 3：
Dendrobium candidum：600 grams；Rhizoma Gastrodiae：300 grams；The seed of Oriental arborvitae：180 grams；Spina date seed：100 grams；The vine of multiflower knotweed：180 grams；Matrimony vine
Son：100 grams.
The taste herb powder of the above 6 is taken, 70% alcohol reflux extracts 2 times, each 2h, filtering, is concentrated after filtrate recycling ethanol
It is standby after to the medicinal extract of relative density 1.20；Residue adds water to cook twice, the 1st 2h, the 2nd 1.5h, collecting decoction, is concentrated into
It is standby after the medicinal extract of relative density 1.2.Appropriate amount of starch, dextrin are placed in suitable vessels, add hot dipping cream, rapid stirring is equal
It is even, softwood is made, in wet granular is made in oscillating granulator, particle is spread out in suitable vessels (use to be dried), and drying temperature is
60 DEG C, particle is stirred in drying process in time, dried particle adds magnesium stearate toward sieving whole grain is carried out after whole grain,
Mix, calculate tabletting after piece weight, produce 2000, tablet, pack.
Embodiment 4：
Carry out promoting sleeping animal to test with the dendrobium candidum compound extraction medicinal extract of the above embodiment of the present invention 1：
1st, purpose
Up to more than 1min it is to be commented into index of sleeping with mouse righting reflex loss using the sub-threshold dose method of yellow Jackets
Valency evaluates sleep peacefully piece, the sedative-hypnotic effect of Chinese medicine compound prescription.
2nd, experiment material
2.1 laboratory sample：
Sleep peacefully piece (tablet, crush, cross 100 mesh sieves)
Chinese medicine compound prescription, recovery rate：38.5%
2.2 medicines and reagent
Diazepam tablet (stable content 2.5mg/ every)
Yellow Jackets：BIOSHARP, lot number：821028
Physiological saline：SIGMA ALDRICH, lot number：050M0135V.
Tween-20 (guaranteed reagent RG)：Beijing Suo Laibao Science and Technology Ltd, lot number：T8220.
2.3 laboratory apparatus
Electronic analytical balance：PrecisaXS125A.
Electronic balance：Yuyao City Jin Nuo balance equipments Co., Ltd.
ZZ-6 mouse autonomic activities testers：Chengdu TME Technology Co., Ltd.
2.4 experimental animal
Kunming mouse, cleaning grade, body weight 18g-24g, male and female half and half, provided by Kunming Medical University.Quality certification number：
SCXK (river) 2008-24 lot numbers：Dossy2012-4.
The preparation of 2.5 stocks of drugs
1. the configuration of yellow Jackets 60mg/kg mother liquors：Every mouse presses 0.2ml/10g volume administrations, then required penta bar
It is than appropriate sodium solution concentration：60mg/20ml=3mg/ml, used according to mouse 96 used, every body weight about 25g, estimation
Nembutal sodium solution volume is：0.2ml/10g × 25g × 96=48ml, then required yellow Jackets be quality 3mg/ml ×
48ml=144mg.
With method：Precision weighs yellow Jackets 144mg, and physiological saline is dissolved to 48ml.
2. the configuration for piece of sleeping peacefully：Dosage：High dose is 1.2g/kg, middle dosage 900mg/kg, low dosage 600mg/
Kg, every mouse press 0.2ml/10g volume administrations, then administration concentration is high dose 60mg/ml, middle dosage 45mg/ml, low dosage
30mg/ml, the volume for needing various concentrations decoction altogether is 25g/ × 12 × 1 day × 0.2ml/10g=6ml, then required to sleep peacefully
Tablet quality is high dose 60mg/ml × 6ml=360mg, middle dosage 45mg/ml × 6ml=270mg, 30mg/ml × 6ml=
180mg。
With method：Precision weighs constant weight thing 360mg and in beaker, takes Tween-20 a small amount of slowly with distilled water with liquid-transfering gun
(preventing from emulsifying) is added in beaker in equal volume, is fully dissolved when adding Tween-20 3ml, this liquid is transferred in graduated cylinder, is used
Distilled water is dissolved to 6ml.
3. diazepam tablet configures：Dosage is 50mg/kg, and every mouse presses 0.2ml/10g volume administrations, then administration concentration is
2.5mg/ml.The volume of decoction needed for daily is 25g/ × 12 × 0.2ml/10g=6ml, then required stable quality is
15mg (needs 6 diazepam tablets).
With method：Take and stabilize 6 in beaker, grind, take Tween-20 slowly (to be prevented on a small quantity with distilled water with liquid-transfering gun
Emulsification) add in equal volume in beaker, fully dissolved when adding Tween-20 3ml, this liquid is transferred in graduated cylinder, uses distilled water
It is dissolved to 6ml.
4. configured with 2 Chinese medicine compound prescriptions：Medicinal extract 360mg is taken, same volume hot water is added, is settled to 6ml.
5. the configuration of the distilled water containing Tween-20：Physiological saline 3ml is taken with graduated cylinder, adds Tween-20 3ml, it is fully molten
Solution, distilled water are settled to 15ml.
Note：The equal 4 DEG C of preservations after preparing of above decoction
3rd, experimental method
3.1 animal packets (in experiment the previous day)
Healthy Kunming mouse 96 is taken, male and female half and half, it is following (shown in table 1) to be randomly divided into 8 groups：
The Kunming mouse of table 1 is grouped
| Kunming mouse sum is total | Kunming mouse packet count |
| Mouse 96 (male and female half and half) | Blank group 12 (male and female half and half) |
| Positive group 12 (male and female half and half) | |
| Sleep peacefully piece low dosage 12 (male and female half and half) | |
| Piece middle dosage of sleeping peacefully 12 (male and female half and half) | |
| Sleep peacefully piece high dose 12 (male and female half and half) | |
| Compound low dosage 12 (male and female half and half) | |
| Compound middle dosage 12 (male and female half and half) | |
| Compound high dose 12 (male and female half and half) |
3.2 animals are administered
Do and first carry out preliminary experiment with 12 mouse before formally testing, determine pentobarbital sodium sub-threshold lull dosage (penta bar of ratio
Appropriate sodium 40mg/kg body weight), formally tested with this dosage.Water 6h is can't help in fasting before administration, and every mouse presses 0.2ml/10g
Volume gastric infusion, respectively by senior middle school's low dosage administration, it is administered 7 days, in administration half an hour after test mouse autonomic activities every time
Number, mouse is put into respectively in autonomic activities tester after 5 minutes, number of activities in start recording mouse 2 minutes, in last
The yellow Jackets of administration 1 hour pneumoretroperitoneum injection sub-threshold dose, with righting reflex loss up to more than 1min be into index of sleeping,
Observe the sleep number of elements of each group mouse.
4th, experimental result
Experimental result is shown in Table 2, table 3.
The mouse autonomic activities test result of table 2
| Group | Total mice | Number of activities | Standing number |
| Blank group | 12 | 3.33±2.348 | 25.25±6.797 |
| Positive controls | 12 | 1.20±2.251 | 3.30±5.229 |
| Sleep peacefully piece low dose group | 11 | 3.36±2.501 | 18.55±13.859 |
| Sleep peacefully piece middle dose group | 12 | 4.45±4.132 | 11.45±8.847 |
| Sleep peacefully piece high dose group | 12 | 3.50±2.576 | 11.83±10.786 |
| Chinese medicine compound prescription low dose group | 12 | 2.00±1.348 | 15.67±7.947 |
| Chinese medicine compound prescription middle dose group | 12 | 2.50±3.503 | 11.83±8.657 |
| Chinese medicine compound prescription high dose group | 12 | 2.08±2.251 | 10.33±7.303 |
The mouse sleep rate test result of table 3
| Group | Total mice | Sleep number of elements | Sleep rate % |
| Blank group | 12 | 2 | 16.7 |
| Positive controls | 12 | 12 | 100 |
| Sleep peacefully piece low dose group | 11 | 4 | 36.4 |
| Sleep peacefully piece middle dose group | 12 | 5 | 41.6 |
| Sleep peacefully piece high dose group | 12 | 7 | 58.3 |
| Chinese medicine compound prescription low dose group | 12 | 6 | 50 |
| Chinese medicine compound prescription middle dose group | 12 | 6 | 50 |
| Chinese medicine compound prescription high dose group | 12 | 7 | 58.3 |
From experimental result as can be seen that the dendrobium candidum compound extract prepared by embodiment 1 can significantly reduce mouse
Number of activities, standing number, with blank control significant difference.The dendrobium candidum compound extract prepared by embodiment 1, which is carried out, to be promoted
The sleep experiment for entering pentobarbital sodium sub-threshold lull dosage mouse shows：1, dendrobium candidum compound group promote sleeper effect with it is current
Quasi-font size medicine piece of sleeping peacefully compares, and difference is not notable during p=0.05, and 2, dendrobium candidum compound group is compared with control group, in p=
When 0.05 and 0.01, difference is all extremely notable.Sleep can be effectively facilitated by showing the dendrobium candidum compound of the present invention, and its promotion is slept
Dormancy effect and quasi-font size medicine piece of sleeping peacefully are suitable.
Claims (5)
1. a kind of dendrobium candidum compound preparation, the by weight percentage compound preparation are made up of following components, and each component is total
With equal to 100%,
The compound preparation is directly to crush the pulvis formed by above-mentioned each component, and it is more than 300 mesh ultra-fine through being crushed to refer to medicine
Powder, or the extract that above-mentioned each component extracts to obtain via water or organic solvent, or by percentage by weight be 10%~90%
The pharmaceutical preparation that the extract of above-mentioned each component and 90%~10% excipient substance or complementary composition are prepared；Described
Every 100 grams of the powdered extract of dendrobium candidum each component extract is more than 10 grams containing polysaccharide, and every 100 grams are more than 0.05 containing Gastrodin
Gram.
2. the preparation method of a kind of dendrobium candidum compound preparation described in claim 1, it is characterised in that this method includes following
Step：
A, dendrobium candidum, rhizoma Gastrodiae, the seed of Oriental arborvitae, spina date seed, the vine of multiflower knotweed, the fruit of Chinese wolfberry are directly beaten into powder and obtains powder；Or by above-mentioned medicinal material
Extracted after crushing with hot-water soak, compound extract medicinal extract is obtained after gained Aqueous extracts recycle-water；Or it will be used after above-mentioned pulverizing medicinal materials
20%~95% alcohol reflux is extracted, and compound extract medicinal extract is obtained after gained extract solution recycling design；
B, compound medicinal powder obtained by a or extract medicinal extract are added into pharmaceutically acceptable auxiliary material or complementary composition is prepared into
Common dosage forms pharmaceutically.
3. application of the compound preparation in the medicine for promoting sleep is prepared described in claim 1.
4. application of the compound preparation in the health products for promoting sleep are prepared described in claim 1.
5. application of the compound preparation in the health products for preparing strengthen immunity described in claim 1.
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| CN104606510B (en) * | 2014-12-31 | 2017-09-15 | 浙江济公缘药业有限公司 | Dendrobium candidum compound preparation for treating cancer-related sleep-disorder |
| CN105920186B (en) * | 2016-06-07 | 2019-12-31 | 华南师范大学 | A Chinese medicinal composition for treating hemorrhoid, and its preparation method |
| CN106360716A (en) * | 2016-08-22 | 2017-02-01 | 蓬莱海洋（山东）股份有限公司 | Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof |
| CN113181205B (en) * | 2021-04-19 | 2023-07-14 | 苏州人本药业有限公司 | Pharmaceutical composition comprising NMN and use thereof |
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| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
| CN103843952A (en) * | 2014-01-15 | 2014-06-11 | 云南云尚生物技术有限公司 | Processing method of dendrobium officinale leaf tea |
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| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
| CN103843952A (en) * | 2014-01-15 | 2014-06-11 | 云南云尚生物技术有限公司 | Processing method of dendrobium officinale leaf tea |
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| 二仁二子汤治疗顽固性失眠127例;陈小明;《实用中医药杂志》;20030630;第19卷(第06期);294 * |
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