CN106360716A - Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof Download PDFInfo
- Publication number
- CN106360716A CN106360716A CN201610703187.0A CN201610703187A CN106360716A CN 106360716 A CN106360716 A CN 106360716A CN 201610703187 A CN201610703187 A CN 201610703187A CN 106360716 A CN106360716 A CN 106360716A
- Authority
- CN
- China
- Prior art keywords
- extract
- sleep
- parts
- tablet
- organisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000007958 sleep Effects 0.000 title claims abstract description 89
- 230000036039 immunity Effects 0.000 title claims abstract description 66
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000000284 extract Substances 0.000 claims abstract description 120
- 239000003826 tablet Substances 0.000 claims description 68
- 210000000582 semen Anatomy 0.000 claims description 45
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 33
- 239000002994 raw material Substances 0.000 claims description 33
- 239000003795 chemical substances by application Substances 0.000 claims description 30
- 239000000463 material Substances 0.000 claims description 30
- 239000003085 diluting agent Substances 0.000 claims description 23
- 239000011230 binding agent Substances 0.000 claims description 21
- 239000000314 lubricant Substances 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000008187 granular material Substances 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 235000013402 health food Nutrition 0.000 claims description 11
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 10
- 239000007968 orange flavor Substances 0.000 claims description 10
- 108010011485 Aspartame Proteins 0.000 claims description 9
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 9
- 239000000605 aspartame Substances 0.000 claims description 9
- 229960003438 aspartame Drugs 0.000 claims description 9
- 235000010357 aspartame Nutrition 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- 229920001592 potato starch Polymers 0.000 claims description 6
- 229930182490 saponin Natural products 0.000 claims description 6
- 150000007949 saponins Chemical class 0.000 claims description 6
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 claims description 5
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 235000021286 stilbenes Nutrition 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- PUQSUZTXKPLAPR-KSSYENDESA-N 4-(beta-D-Glucopyranosyloxy) benzyl alcohol Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1ccc(CO)cc1 PUQSUZTXKPLAPR-KSSYENDESA-N 0.000 claims description 3
- 229930193974 gastrodin Natural products 0.000 claims description 3
- 229930182478 glucoside Natural products 0.000 claims description 3
- PUQSUZTXKPLAPR-NZEXEKPDSA-N helicidol Natural products O([C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](CO)O1)c1ccc(CO)cc1 PUQSUZTXKPLAPR-NZEXEKPDSA-N 0.000 claims description 3
- -1 stilbene glucoside Chemical class 0.000 claims description 3
- 239000007767 bonding agent Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 238000005304 joining Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 41
- 239000008280 blood Substances 0.000 abstract description 15
- 210000004369 blood Anatomy 0.000 abstract description 14
- 210000002216 heart Anatomy 0.000 abstract description 13
- 210000004185 liver Anatomy 0.000 abstract description 12
- 240000005373 Panax quinquefolius Species 0.000 abstract description 11
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract description 11
- 210000000952 spleen Anatomy 0.000 abstract description 10
- 201000010099 disease Diseases 0.000 abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 9
- 210000004072 lung Anatomy 0.000 abstract description 9
- 210000003734 kidney Anatomy 0.000 abstract description 8
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 230000033228 biological regulation Effects 0.000 abstract description 3
- 206010012335 Dependence Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 32
- 230000036541 health Effects 0.000 description 32
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 30
- 206010022437 insomnia Diseases 0.000 description 30
- 241000699670 Mus sp. Species 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 15
- 230000006870 function Effects 0.000 description 15
- FTOAOBMCPZCFFF-UHFFFAOYSA-N barbitone sodium Natural products CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 14
- 239000000047 product Substances 0.000 description 12
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 11
- 239000012467 final product Substances 0.000 description 11
- 229960002275 pentobarbital sodium Drugs 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 10
- 238000003304 gavage Methods 0.000 description 10
- 235000015165 citric acid Nutrition 0.000 description 9
- 229960000796 barbital sodium Drugs 0.000 description 8
- RGHFKWPGWBFQLN-UHFFFAOYSA-M sodium;5,5-diethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CCC1(CC)C([O-])=NC(=O)NC1=O RGHFKWPGWBFQLN-UHFFFAOYSA-M 0.000 description 8
- 230000006872 improvement Effects 0.000 description 7
- 230000004620 sleep latency Effects 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 235000008434 ginseng Nutrition 0.000 description 6
- 235000019640 taste Nutrition 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241000345998 Calamus manan Species 0.000 description 4
- 241000222336 Ganoderma Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 235000012950 rattan cane Nutrition 0.000 description 4
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 4
- 235000017709 saponins Nutrition 0.000 description 4
- 238000004904 shortening Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000668709 Dipterocarpus costatus Species 0.000 description 3
- 240000001341 Reynoutria japonica Species 0.000 description 3
- 235000018167 Reynoutria japonica Nutrition 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 229960002319 barbital Drugs 0.000 description 3
- 230000005059 dormancy Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 208000019116 sleep disease Diseases 0.000 description 3
- 208000020685 sleep-wake disease Diseases 0.000 description 3
- 235000015424 sodium Nutrition 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- DUUGKQCEGZLZNO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Chemical compound C1=C(O)C=C2C(CC(=O)O)=CNC2=C1 DUUGKQCEGZLZNO-UHFFFAOYSA-N 0.000 description 2
- 206010003084 Areflexia Diseases 0.000 description 2
- 241001289529 Fallopia multiflora Species 0.000 description 2
- 241000305492 Gastrodia Species 0.000 description 2
- 241000305491 Gastrodia elata Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 2
- 241001247821 Ziziphus Species 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000000469 ethanolic extract Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 2
- 229960003987 melatonin Drugs 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000003305 oral gavage Methods 0.000 description 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000028527 righting reflex Effects 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- RANQPHKSRUUPKK-UHFFFAOYSA-N 3-O-[alpha-L-arabinofuranosyl-(1->2)-O-{beta-D-glucopyranosyl-(1->3)}-(alpha-L-arabinopyranosyl)]jujubogenin Natural products CC(C)=CC1CC(C)(O)C2C3CCC4C5(C)CCC(OC6OCC(O)C(OC7OC(CO)C(O)C(O)C7O)C6OC6OC(CO)C(O)C6O)C(C)(C)C5CCC4(C)C33COC2(C3)O1 RANQPHKSRUUPKK-UHFFFAOYSA-N 0.000 description 1
- RVWZUOPFHTYIEO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Natural products C1=C(O)C=C2C(C(=O)O)=CNC2=C1 RVWZUOPFHTYIEO-UHFFFAOYSA-N 0.000 description 1
- 239000003310 5-hydroxyindoleacetic acid Substances 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 208000012639 Balance disease Diseases 0.000 description 1
- 101800005049 Beta-endorphin Proteins 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 102000002512 Orexin Human genes 0.000 description 1
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000612118 Samolus valerandi Species 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 102100027690 Spexin Human genes 0.000 description 1
- 101710175975 Spexin Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000004056 anthraquinones Chemical group 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 231100000880 dysequilibrium Toxicity 0.000 description 1
- 230000000517 effect on sleep Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229930192286 jujuboside Natural products 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000002474 noradrenergic effect Effects 0.000 description 1
- 108060005714 orexin Proteins 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000010341 ping gan Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- SQMCFUSVGSBKFK-UHFFFAOYSA-M sodium;5-(cyclohexen-1-yl)-1,5-dimethylpyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].O=C1N(C)C(=O)[N-]C(=O)C1(C)C1=CCCCC1 SQMCFUSVGSBKFK-UHFFFAOYSA-M 0.000 description 1
- 230000002557 soporific effect Effects 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229930182493 triterpene saponin Natural products 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to a traditional Chinese medicinal composition for improving body immunity and sleep, and a preparation method thereof. The traditional Chinese medicinal composition comprises, by weight, 6-13 parts of American ginseng, 20-35 parts of spine date seed extract, 20-35 parts of rhizoma gastrodiae extract and 20-35 parts of Caulis Polygoni Multiflori extract. The American ginseng, the spine date seed extract, the rhizoma gastrodiae extract and the Caulis Polygoni Multiflori extract are combined to realize regulation of bodies from the heart, the liver, the spleen, the lung, the kidney, qi, blood, yin and yang, so sleep is improved through improving the body immunity, both manifestation and root cause of disease are treated; and a tablet has the characteristics of good safety and effectiveness, no toxic or side effects, no addiction, convenience in carrying, and convenience in taking.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition improving immunity of organisms and sleep and preparation method thereof simultaneously, belong to guarantor
Health food technical field.
Background technology
People in life, accounts for therein 1/3 the length of one's sleep, and the therefore height of sleep quality affects all one's life of people, bag
Include the learning efficiency, work efficiency, quality of life, the every aspect such as health.Modern modal sleep disorder is insomnia, loses
The symptom slept is mainly shown as that the length of one's sleep is not enough or sleep is not yet done.Accelerate with social rhythm, stress increases, and sleeps
The sickness rate of dormancy obstacle is in steeply rise trend.At present, the medicine for the treatment of insomnia both at home and abroad is mainly Chinese medicine based on Western medicine
Supplemented by, but Western medicine, such as stable and melatonin etc., long-term taking has certain additive, dependency and has a sleepless night back after being discontinued
Jump etc. side effect and bad should, and derive from the Chinese medicine of natural plants, because its composition is various, achievable Mutiple Targets are worked in coordination with
Effect, and toxic and side effects are low, then be comparatively safe effective clinical application, more worth are exploited.
Traditional Chinese medical science insomnia is called to be insomnia, and the cause of disease is eating and drinking without temperance, abnormal emotion, body void lose foster, maladjustment in work and rest etc., and pathogenesis is main
Have battalion to defend imbalance, yin and yang imbalance, internal organs damage, deficiency of qi and blood, stagnation of QI due to depression of the liver, phlegm-blood stasis internal resistance, sick position in the heart, with liver, spleen, lung,
Kidney is closely related it is seen that insomnia is to be led to by internal body viscera internal organs function general disturbance, is also caused because body itself is weak, therefore
From the angle adjusting body vital organs of the human body function, YIN and YANG balance regulating and raising and immunity of organisms, insomnia is treated, can be real
The treating both the principal and secondary aspects of a disease now having a sleepless night.
Semen Ziziphi Spinosae is rhamnaceae plant wild jujube ziziphus jujaba mill.var.spinosa (bunge) hu ex
The dry mature seed of h.f.chou.Enter the heart, liver, gallbladder meridian, can nourishing heart cloudy, the liver benefiting blood and have the effect calmed the nerves, be tranquilizing by nourishing the heart it
Key medicine, the treatment to the disease of " consumptive disease with restlessness insomnia " has special effect.The main chemical compositions of this product are triterpene saponin and flavonoid
Composition, additionally contains fatty oil and several amino acids, vitamin, polysaccharide etc..Modern pharmacological research shows, jujuboside,
Flavonoid glycoside, water extraction and its ethanol extract all have functions that tranquilizing soporific.
Rhizoma Gastrodiae is the dry tuber of orchid Rhizoma Gastrodiae gastrodia elata bl..Enter Liver Channel, this product can cease liver
Wind, and energy Pinggan Yang, for controlling the key medicine of dizziness, headache.The main effective ingredient of this product is Gastrodine, gastrodine etc., Shang Han
There are polysaccharide, vitamin, the composition such as aminoacid.Modern pharmacological research shows, the water extract of Rhizoma Gastrodiae, ethanol extract and its different preparation,
Can be all that the voluntary activity of mice significantly reduces, and barbital sodium can be extended, mice sleep that hexobarbitone sodium causes
Time.Gastrodia elata polysaccharide has functions that enhancing human body immunity power, and modern clinic test also indicates that, the injection of Rhizoma Gastrodiae can be used for controlling
Treat the diseases such as dizziness, headache, sleep disorder, its mechanism of action is to recover the excited dysequilibrium and between process of inhibition of cerebral cortex,
It has preferable therapeutic effect to intractable insomnia and non-simple insomnia.
Caulis Polygoni Multiflori be polygonum multiflorum thunb polygonum multiflorum thunb. rattan is dried.Enter the heart, liver
Warp, can take a tonic or nourishing food to build up one's health cloudy blood, and tranquilizing by nourishing the heart is it is adaptable to the insomnia of deficiency of YIN insufficiency of blood.This product effective ingredient is Anthraquinones and stilbene
Methods of glycosides, and its extract also has the preferable function of improving immunity of organisms.
Radix Panacis Quinquefolii is the root of Araliaceae Radix Panacis Quinquefolii panax quinquefolium l..Enter lung, the heart, kidney, spleen channel, energy
Tonification vigour, yin nourishing of relieving inflammation or internal heat, and the work(of its tonification vigour is slightly gentle compared with Radix Ginseng, and more notable to spleen and lung deficiency of both QI and YIN curative effect, long
Phase takes and has the obvious activity increasing immunity of organisms.
Health food about improving the health care of sleep function is broadly divided into three classes: hormoness (as melatonin etc.), Chinese medicine class at present
And both mixing classes.The product adding hormoness has more toxic and side effects because of it, is unfavorable for taking for a long time, and with
The continuous improvement of people's health consciousness, pure Chinese medicine class product accounts for its market share proportion and will raise year by year, but will change at present
The product that the medicinal and edible Chinese medicine of kind sleep is combined with the Chinese medicine of the medicine-food two-purpose improving immunity of organisms is less, from raising machine
The angle of body immunity to excite the Product Report of the curative effect improving the health care of sleep less further.
A kind of Chinese patent document cn1872293a (application number: 200610051027.9) disclose Chinese medicine improving the health care of sleep
Health product, are related to health product.It is with 30～56 parts of Rhizoma Gastrodiaes, 20～36 parts of Radix Panacis Quinquefoliis, 11～21 parts of Semen Ziziphi Spinosaes, 25～45 parts of spirits
Sesame, 12～22 portions of Bulbus Liliies, 7～15 parts of Rhizoma Polygonatis, 5～9 parts of Radix Salviae Miltiorrhizaes are principal agent, add appropriate amount of auxiliary materials cereal starch or potato class are formed sediment
Powder or dextrin or wild plant starch form.This prescription has certain therapeutic effect to insomnia of the middle aged and elderly, but its prescription with
Rhizoma Gastrodiae, Radix Panacis Quinquefolii and Ganoderma are principal agent, be more suitable for the treatment of deficiency of vital energy institute induced insomnia, and Semen Ziziphi Spinosae is as the key medicine for the treatment of insomnia
Required onset amount is larger, and in the party, Semen Ziziphi Spinosae proportion is relatively low, therefore this prescription product may be taken by raising
Dosage or extend Time of Administration and play therapeutic effect.
A kind of Chinese patent document cn103202478a (application number: 201310159071.1) disclose guarantor improving the health care of sleep
Health food and preparation method thereof, is made up of 10% Radix Panacis Quinquefolii, 25% Ganoderma, 20% Fructus Schisandrae Chinensis, 30% Poria, 15% Semen Ziziphi Spinosae.
Through Ganoderma, Fructus Schisandrae Chinensis, Poria, Semen Ziziphi Spinosae raw material extracts powder processed and Radix Panacis Quinquefolii powder allotment is mixed to prepare.This prescription reuse Ganoderma and
Poria, more stresses and the insomnia caused by QI invigorating diuretic and deficiency of both the heart and spleen insufficiency of vital energy and blood, and Semen Ziziphi Spinosae proportion in this prescription
Also relatively low.
Chinese patent document cn 104013834a (application number: 201410281080.2) disclose one kind there is improvement and sleep
The granule of dormancy effect, it with 3～9 parts of Radix Panacis Quinquefoliis, 10～15 parts of Rhizoma Gastrodiaes, 10～15 parts of Semen Ziziphi Spinosaes, 10～20 parts of Cortexs Eucommiae, 5～
10 parts of Radix Ginsengs are principal agent, are mixed to prepare.Intimate Radix Panacis Quinquefolii and Radix Ginseng two taste traditional tonic medicine is contained in this prescription, and Radix Ginseng
Ratio in prescription is relatively higher, and because void is not mended, excessive use Radix Ginseng may increase the insomnia of some insomniaies
Symptom.
Chinese patent document cn 105412271a (application number: 201510802277.0) disclose one kind and sleep for improvement
The compositionss and preparation method thereof slept, it with 10～60 parts of Golden jujube extracting solution, 10～45 parts of Semen Ziziphi Spinosae extracting solution, 10～45
Part Caulis Polygoni Multiflori extracting solution is main component, is mixed to prepare.This prescription lays particular emphasis on benefiting qi and nourishing blood, is more suitable for caused by insufficiency of vital energy and blood
Insomnia.
Therefore it provides one kind can carry out body regulation from the heart, liver, spleen, lung, kidney, gas, blood, yin, yang Multi-angle omnibearing,
For improving immunity of organisms and improving the Chinese medicine composition of the insomnia that many reasons lead to, imperative.
Content of the invention
For the deficiencies in the prior art, the present invention provides a kind of Chinese medicine composition simultaneously improving immunity of organisms and sleep
And preparation method thereof, the medicinal and edible Chinese medicine being usually used in improving immunity of organisms and improving the health care of sleep is extracted by the compositionss of the present invention
Thing carries out scientific and reasonable proportioning, realizes adjusting from Multi-angle omnibearings such as the heart, liver, spleen, lung, kidney, gas, blood, yin, yangs, to multiple
The insomnia that reason leads to all has a better role, and can achieve the dual-use function simultaneously improving immunity of organisms and sleep, right
Human body has no adverse reaction.
Technical scheme is as follows:
A kind of compositionss simultaneously improving immunity of organisms and sleep, the raw material including following weight portion forms:
6～13 parts of Radix Panacis Quinquefolii, 20～35 parts of Semen Ziziphi Spinosae extract, 20～35 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 20
～35 parts.
According to the invention it is preferred to, improve immunity of organisms and the compositionss of sleep while described, including following weight
The raw material composition of part:
8～12 parts of Radix Panacis Quinquefolii, 26～34 parts of Semen Ziziphi Spinosae extract, 26～34 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 26
～34 parts.
According to the invention it is preferred to, improve immunity of organisms and the compositionss of sleep while described, including following weight
The raw material composition of part:
9～11 parts of Radix Panacis Quinquefolii, 28～32 parts of Semen Ziziphi Spinosae extract, 28～32 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 28
～32 parts.
According to the invention it is preferred to, improve immunity of organisms and the compositionss of sleep while described, including following weight
The raw material composition of part:
10 parts of Radix Panacis Quinquefolii, 30 parts of Semen Ziziphi Spinosae extract, 30 parts of Rhizoma Gastrodiae extract, 30 parts of Caulis Polygoni Multiflori extract.
According to the invention it is preferred to, total saponin content >=2.5wt% in described Radix Panacis Quinquefolii extract.
According to the invention it is preferred to, total saponin content >=2.2wt% in described Semen Ziziphi Spinosae extract.
According to the invention it is preferred to, stilbene glucoside content >=0.2wt% in described Caulis Polygoni Multiflori extract.
According to the invention it is preferred to, gastrodin content >=1.0wt% in described Rhizoma Gastrodiae extract.
According to the present invention, a kind of health food simultaneously improving immunity of organisms and sleep, can improve machine with above-mentioned simultaneously
The compositionss of body immunity and sleep are effective ingredient, add pharmaceutic adjuvant, make tablet, granule or capsule, medicinal auxiliary
The addition of material accounts for effective ingredient and the 16-25% of pharmaceutic adjuvant gross weight.
Health food according to the present invention it is preferred that described pharmaceutic adjuvant be diluent, binding agent, disintegrating agent and rectify
Taste agent.Effective ingredient and pharmaceutic adjuvant make tablet through pelletize, tabletting.Preferably, the addition of diluent, binding agent and disintegrating agent
Amount accounts for the 15-22% of total weight of tablet, and the addition of correctivess accounts for the 0.5-2% of total weight of tablet；It is further preferred that it is described
Diluent be potato starch, binding agent and disintegrating agent are Microcrystalline Cellulose, diluent, binding agent, the quality of disintegrating agent
Than for 3: 1: 1～1: 3: 3, correctivess are the mixture of aspartame, citric acid and orange flavor, aspartame and citric acid
Mass ratio is 1: 1～1: 2, and the addition of orange flavor accounts for the 0.5-1% of tablet total amount.
Health food according to the present invention, it is preferred that described tablet, also includes lubricant, the addition of lubricant accounts for
The 1-3% of total weight of tablet, described lubricant is magnesium stearate.
According to the health food of the present invention, the preparation method of described tablet, comprise the following steps that
1) Semen Ziziphi Spinosae extract, Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract and Radix Panacis Quinquefolii were pulverized 60-80 mesh sieve respectively,
Weigh screened material by proportioning respectively, mix homogeneously obtains mixed material powder；
2) press amount ratio and add diluent, binding agent and disintegrating agent, mix homogeneously in above-mentioned mixed material powder, mixed
Compound material；
3) mixed material is heated pelletize, first mix 5～15 minutes, when pelletize leaving air temp reaches 30～60 DEG C, spray
Ethanol solution, at 50～80 DEG C drying so that material moisture is controlled in below 5.0wt%, then cross 14～20 mesh sieves carry out whole
Grain；
4) by step 3) granule after granulate adds correctivess and mix lubricant 10-15 minute, and tabletting is obtained can be simultaneously
Improve immunity of organisms and the tablet of sleep.
According to the invention it is preferred to, this can improve immunity of organisms and the tablet weight of sleep simultaneously is 0.8-1.2g, piece
The different limit of the method for double differences is ± 5%, and daily 3 times, 4 tablets once, can meet the health care work(improving the health care of sleep and improving immunity of organisms
Energy.
Preparation method according to Tablets is it is preferred that step 3) in the concentration of ethanol solution be 70～90wt%, excellent
Choosing, the concentration of ethanol solution is 85wt%.
According to the invention it is preferred to, can improve immunity of organisms and the tablet of sleep is tabletting or chewable tablet simultaneously.
The invention by clinically prove, the effective medicine-food two-purpose for the treatment of safety to the insomnia of different reasons
Chinese medicine (Semen Ziziphi Spinosae, Rhizoma Gastrodiae, Caulis Polygoni Multiflori) is compatible with the Radix Panacis Quinquefolii that can significantly improve immunity of organisms, through reasonably combined, can
Realize adjusting from Multi-angle omnibearings such as the heart, liver, spleen, lung, kidney, gas, blood, yin, yangs, side is small but excellent, have and improve the health care of sleep, calm
Calm the nerves, benefiting qi and nourishing blood, nourishing YIN for suppressing the hyperactive YANG the effects such as, the sleep disorder (physiological or pathologic) to many reasons all has preferably
Alleviate and therapeutic effect, and have no toxic side effect and additive, taking convenience, be easy to carry.
Through many experiments, the present inventor has been surprisingly found that Semen Ziziphi Spinosae extract, Caulis Polygoni Multiflori extract, Rhizoma Gastrodiae extract
Thing and Radix Panacis Quinquefolii compound and have reached unexpected effect, Semen Ziziphi Spinosae extract, Caulis Polygoni Multiflori extract and Rhizoma Gastrodiae extract treatment
The mechanism of insomnia is respectively and changes the amount (5-hydroxy tryptamine, 5-hydroxyindoleacetic acid and beta-endorphin) of monoamine neurotransmitter, raises
Benzodiazepine receptoroid, reduces intracerebral no level and il-1 β, tnf- α, the content of sp and orexin a, reduces intracerebral nor-
Adrenergic content, therefore three shares, can achieve the insomnia that many reasons are caused and the good treatment of intractable insomnia
Effect, the addition of Radix Panacis Quinquefolii has obvious facilitation, boosting qi and nourishing yin to the raising effect of immunity of organisms, thus can enter
One step promotes the effect improving the health care of sleep of Semen Ziziphi Spinosae extract, Caulis Polygoni Multiflori extract and Rhizoma Gastrodiae extract complex, fundamentally
Play double effects to improving the health care of sleep and improving immunity of organisms, reached raising immunity of organisms, improved the health care of sleep and run neck and neck
Effect, the present invention can be eaten for a long time, and will not produce any dependence effect, to conscience spleen and lung kidney negative and positive of qi and blood bootstrap, can be effective
Improve insomnia and enhancing human body immunity power, play the role of auxiliary treatment to Other diseases.
Advantages of the present invention:
1st, Radix Panacis Quinquefolii extract and Semen Ziziphi Spinosae extract, Rhizoma Gastrodiae extract fleece-flower root rattan extract compatibility are used by the present invention
Medicine, can achieve the regulation to body from multi-angles such as the heart, liver, spleen, lung, kidney, gas, blood, yin, yangs.
2nd, the present invention realizes, to the improvement slept, playing the effect for the treatment of both the principal and secondary aspects of a disease from the angle improving immunity of organisms.
3rd, the tablet of the present invention has safely and effectively, has no toxic side effect, no additive, easy to carry, is easy to the spy taking
Point.
Specific embodiment
With reference to specific embodiment, the present invention is further illustrated.
Used in embodiment, raw material is conventional commercial products, wherein:
Radix Panacis Quinquefolii extract is purchased from Shaanxi Risperdal Consta hall plant material company limited, and specification is 10:1 (10 parts of crude drug outputs 1
Part extract), American ginseng total saponins content is more than or equal to 2.5wt%.
Semen Ziziphi Spinosae extract is purchased from Shaanxi Risperdal Consta hall plant material company limited, and specification is 10:1 (10 parts of crude drug outputs 1
Part extract), Semen Ziziphi Spinosae total saponins content is more than or equal to 2.2wt%.
Rhizoma Gastrodiae extract is purchased from Shaanxi Risperdal Consta hall plant material company limited, and specification is 10:1 (1 part of 10 parts of crude drug outputs
Extract), gastrodin content is more than or equal to 1.0wt%.
Caulis Polygoni Multiflori extract is purchased from Shaanxi Risperdal Consta hall plant material company limited, and specification is 10:1 (10 parts of crude drug outputs 1
Part extract), stilbene glucoside content is not less than 0.2%.
Embodiment 1
A kind of compositionss that can simultaneously improve immunity of organisms and sleep, the raw material including following weight portion forms:
10.00 parts of Radix Panacis Quinquefolii, 30.00 parts of Semen Ziziphi Spinosae extract, 30.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 30.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product the compositionss that can simultaneously improve immunity of organisms and sleep.
With the above-mentioned tablet as effective ingredient for the compositionss that can improve immunity of organisms and sleep simultaneously, by above-mentioned have carry
High immunity of organisms and the compositionss improving the health care of sleep add diluent, binding agent, disintegrating agent and correctivess through pelletize, tabletting system
?.The addition of wherein diluent, binding agent and disintegrating agent accounts for the 20% of tablet gross mass, and it is total that the addition of correctivess accounts for tablet
The 1% of quality, described diluent is potato starch, and binding agent and disintegrating agent are Microcrystalline Cellulose, diluent, bonding
Agent, disintegrating agent mass ratio be 3: 1: 1, correctivess be aspartame, citric acid and orange flavor mixture, aspartame with
The mass ratio of citric acid is 1: 1, accounts for the 0.5% of tablet gross mass, orange flavor accounts for the 0.5% of tablet gross mass.
Also include lubricant, the addition of lubricant accounts for the 2% of tablet total amount, and described lubricant is magnesium stearate.
The preparation method of the tablet as effective ingredient for the above-mentioned compositionss can improve immunity of organisms and sleep simultaneously, bag
Include step as follows:
1) Radix Panacis Quinquefolii, Semen Ziziphi Spinosae extract, Caulis Polygoni Multiflori extract and Rhizoma Gastrodiae extract were pulverized 80 mesh sieves respectively, by joining
Than weighing screened material respectively, mix homogeneously obtains mixed material powder；
2) press amount ratio and add diluent, binding agent and disintegrating agent in above-mentioned mixed material powder, mix 30 minutes, mixing
Uniformly, obtain mixed material；
3) mixed material is added and in granulator, heat pelletize, first mix 10 minutes, when leaving air temp reaches 43 DEG C, spray
85wt% ethanol solution, drying at 55 DEG C makes material moisture control in below 5.0wt%, then crosses 14 mesh nylon mesh and carries out
Granulate；
4) by step 3) granule after granulate adds correctivess and mix lubricant 12 minutes, and tabletting is obtained and can improve simultaneously
Immunity of organisms and the tabletting of sleep.
Embodiment 2
A kind of compositionss that can simultaneously improve immunity of organisms and sleep, the raw material including following weight portion forms:
7.00 parts of Radix Panacis Quinquefolii, 31.00 parts of Semen Ziziphi Spinosae extract, 31.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 31.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product the compositionss that can simultaneously improve immunity of organisms and sleep.
The tablet with the compositionss of sleep as effective ingredient for the immunity of organisms can be improved with above-mentioned simultaneously, above-mentioned improvement is slept
The compositionss sleeping and improving immunity of organisms add diluent, binding agent, disintegrating agent and correctivess to be obtained through pelletize, tabletting, its
The addition of middle diluent, binding agent and disintegrating agent accounts for the 20% of tablet total amount, and the addition of correctivess accounts for tablet total amount
1%, described diluent is potato starch, and binding agent and disintegrating agent are Microcrystalline Cellulose, diluent, the quality of binding agent
Ratio for 3: 1, accounts for the 17% of tablet gross mass, and disintegrating agent is additional dried starch, accounts for the 3% of tablet gross mass；Correctivess are A Si
Ba Tian, citric acid and orange flavor, aspartame: the mass ratio of citric acid is 1:1, account for the 0.5% of tablet gross mass, Fructus Citri sinensiss are fragrant
Essence accounts for the 0.5% of tablet gross mass.
Also include lubricant, the addition of lubricant accounts for the 2% of tablet total amount, and described lubricant is magnesium stearate.
Preparation method is with embodiment 1.
Embodiment 3
A kind of have the compositionss that can simultaneously improve immunity of organisms and sleep, and the raw material including following weight portion forms:
13.00 parts of Radix Panacis Quinquefolii, 29.00 parts of Semen Ziziphi Spinosae extract, 29.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 29.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product and there are the compositionss improving immunity of organisms and improving the health care of sleep.
With the above-mentioned tablet having and improving immunity of organisms and the compositionss that improve the health care of sleep as effective ingredient, have above-mentioned
Improve immunity of organisms and add diluent, binding agent, disintegrating agent and correctivess through pelletize, tabletting system with the compositionss improving the health care of sleep
, the addition of wherein diluent, binding agent and disintegrating agent accounts for the 20% of tablet gross mass, and it is total that the addition of correctivess accounts for tablet
The 1% of quality, described diluent is potato starch, and binding agent and disintegrating agent are Microcrystalline Cellulose, diluent, binding agent
Mass ratio be 3: 1, account for the 16% of tablet gross mass, disintegrating agent be additional dried starch, account for the 4% of tablet gross mass；Correctivess
For aspartame, citric acid and orange flavor, aspartame: the mass ratio of citric acid is 1:1, accounts for the 0.5% of tablet gross mass,
Orange flavor accounts for the 0.5% of tablet gross mass.
Also include lubricant, the addition of lubricant accounts for the 2% of tablet gross mass, and described lubricant is magnesium stearate.
Preparation method is with embodiment 1.
Embodiment 4
A kind of have the compositionss that can simultaneously improve immunity of organisms and sleep, and the raw material including following weight portion forms:
10.00 parts of Radix Panacis Quinquefolii, 33.00 parts of Semen Ziziphi Spinosae extract, 24.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 33.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product and there are the compositionss improving immunity of organisms and improving the health care of sleep.
The compositionss of the present embodiment are prepared tablet, preparation method is with embodiment 1.
Embodiment 5
A kind of have the compositionss that can simultaneously improve immunity of organisms and sleep, and the raw material including following weight portion forms:
10.00 parts of Radix Panacis Quinquefolii, 31.00 parts of Semen Ziziphi Spinosae extract, 31.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 28.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product and there are the compositionss improving immunity of organisms and improving the health care of sleep.
The compositionss of the present embodiment are prepared tablet, preparation method is with embodiment 1.
Embodiment 6
A kind of have the compositionss that can simultaneously improve immunity of organisms and sleep, and the raw material including following weight portion forms:
9.00 parts of Radix Panacis Quinquefolii, 33.00 parts of Semen Ziziphi Spinosae extract, 32.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 26.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product and there are the compositionss improving immunity of organisms and improving the health care of sleep.
The compositionss of the present embodiment are prepared tablet, preparation method is with embodiment 1.
Embodiment 7
A kind of have the compositionss that can simultaneously improve immunity of organisms and sleep, and the raw material including following weight portion forms:
12.00 parts of Radix Panacis Quinquefolii, 28.00 parts of Semen Ziziphi Spinosae extract, 32.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 28.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product and there are the compositionss improving immunity of organisms and improving the health care of sleep.
The compositionss of the present embodiment are prepared tablet, preparation method is with embodiment 1.
Embodiment 8
A kind of have the compositionss that can simultaneously improve immunity of organisms and sleep, and the raw material including following weight portion forms:
6.00 parts of Radix Panacis Quinquefolii, 34.00 parts of Semen Ziziphi Spinosae extract, 30.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 30.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product and there are the compositionss improving immunity of organisms and improving the health care of sleep.
The compositionss of the present embodiment are prepared tablet, preparation method is with embodiment 1.
Comparative example 1
Without the compositionss of Radix Panacis Quinquefolii, the raw material including following weight portion forms:
34.00 parts of Semen Ziziphi Spinosae extract, 33.00 parts of Rhizoma Gastrodiae extract, 33.00 parts of Caulis Polygoni Multiflori extract, without Radix Panacis Quinquefolii.
Make tablet, preparation method is as follows:
1) Semen Ziziphi Spinosae extract, Caulis Polygoni Multiflori extract and Rhizoma Gastrodiae extract were pulverized 80 mesh sieves respectively, by proportioning respectively
Weigh screened material, mix homogeneously obtains mixed material powder.
2) add in above-mentioned mixed material powder and account for the potato starch of total weight of tablet 20% and the matter of Microcrystalline Cellulose
The mixture than 3:1 for the amount, mixes 20-30 minute, mix homogeneously, obtains mixed material.
3) mixed material is added and heats pelletize in granulator, first mix 10 minutes, when going out a point temperature and reaching 45 DEG C, spray
The ethanol solution of 85wt%, in 60 DEG C of dryings, makes water content control in material below 5.0%, then cross 14 mesh nylon mesh and enter
Row granulate.
4) by step 3) granule after granulate adds dried starch, magnesium stearate, aspartame, citric acid and orange flavor to mix
Close 12 minutes, tabletting is obtained the mixing tablet without Radix Panacis Quinquefolii raw material.
Comparative example 2
A kind of compositionss, the raw material including following weight portion forms:
25.00 parts of Radix Panacis Quinquefolii, 10.00 parts of Semen Ziziphi Spinosae extract, 35.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 30.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product compositionss.
The compositionss of this comparative example are prepared tablet, preparation method is with embodiment 1.
Comparative example 3
A kind of compositionss, the raw material including following weight portion forms:
25.00 parts of Radix Panacis Quinquefolii, 30.00 parts of Semen Ziziphi Spinosae extract, 10.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 35.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product compositionss.
The compositionss of this comparative example are prepared tablet, preparation method is with embodiment 1.
Comparative example 4
A kind of compositionss, the raw material including following weight portion forms:
25.00 parts of Radix Panacis Quinquefolii, 35.00 parts of Semen Ziziphi Spinosae extract, 30.00 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 10.00
Part.Above-mentioned raw materials are sufficiently mixed, obtain final product compositionss.
The compositionss of this comparative example are prepared tablet, preparation method is with embodiment 1.
Experimental example
Embodiment 1 and comparative example 1-4 composition tablet are improved the health care of sleep function human experiment and zoopery.
Experimental example 1
Extend the pentobarbital sodium experiment length of one's sleep
Take mice 40, male and female half and half, after weighing, be randomly divided into 4 groups, every group 40, animal is weighed daily, and presses
2.0ml/100g the oral gavage of body weight, continuous 30 days.Blank group daily gavage distilled water, the test group daily gavage present invention is implemented
The tablet suspension of example 1 preparation, the Radix Panacis Quinquefolii extract solution of contained Radix Panacis Quinquefolii equivalent in the daily gavage of Radix Panacis Quinquefolii group and tablet,
The solution of tablet in contrast groups daily gavage comparative example 1-4, continuous 30 days.After last gavage 15min, to each group animal abdominal cavity
Injection 45mg/kg bw pentobarbital sodium, injection volume is 0.2ml/20g bw, with righting reflex loss for sleep criterion, sees
Examine whether given the test agent extends pentobarbital sodium length of one's sleep, experimental result is shown in Table 1.
Table 1: experimental result
Note: * represents has significant difference, p < 0.05 compared with blank group；
* represents has significant difference, p < 0.01 compared with blank group；
Represent and there is compared with Radix Panacis Quinquefolii group significant difference, p < 0.05；
Represent and there is compared with test group significant difference, p < 0.05.
Test result indicate that, compared with blank group, test group has fabulous prolongation mice pentobarbital sodium to make the length of one's sleep
With there is compared with blank group pole significant difference, each contrast groups also have and preferable extend mice pentobarbital sodium length of one's sleep
Effect, has significant difference compared with blank group, shows that Semen Ziziphi Spinosae extract, Caulis Polygoni Multiflori extract and Rhizoma Gastrodiae extract have
The function of improving the health care of sleep, and when in formula, this three tastes Chinese medicine proportion reduces, can be by improving Radix Panacis Quinquefolii in formula
Shared ratio reaches the preferable function of extending mice no barbital sleep, and three taste Chinese medicines and Radix Panacis Quinquefolii compare as described in test group
After example is reasonably combined, four medicines share, and the effect extending mice no barbital length of one's sleep becomes apparent from, and can reach low cost and drug effect
High effect.
Compared with Radix Panacis Quinquefolii group, test group plays the role of preferably to extend mice pentobarbital sodium length of one's sleep to test group,
And there is significant difference, in conjunction with the experimental data of each contrast groups and Radix Panacis Quinquefolii group, each contrast groups can extend little compared with Radix Panacis Quinquefolii group
Mus pentobarbital sodiums length of one's sleep, and assume significant difference, further demonstrate that, extend the main of mice pentobarbital sodium sleep
Composition is Semen Ziziphi Spinosae extract, Caulis Polygoni Multiflori extract and Rhizoma Gastrodiae extract, but the addition of Radix Panacis Quinquefolii, to prolongation mice penta bar ratio
Appropriate sodium sleep has facilitation, shows can improve the health care of sleep further by improving immunity of organisms.
Experimental result in conjunction with each contrast groups and test group is it is seen that during the prolongation mice pentobarbital sodium sleep of each contrast groups
Between compared with test group, test group has the more preferable effect extending the mice pentobarbital sodium length of one's sleep, and assumes significance
Difference；The prolongation mice pentobarbital sodium of comparative example 2 sample is relatively minimum for the length of one's sleep, meets onset amount needed for Semen Ziziphi Spinosae larger
The fact；Comparative example 1 is similar for the length of one's sleep with the prolongation mice pentobarbital sodium of comparative example 3-4, shows by adding more amount
Radix Panacis Quinquefolii can compensate for the function of Rhizoma Gastrodiae/Caulis Polygoni Multiflori, you can to improve insomnia by improving immunity of organisms auxiliary, but improve
Insomnia effect is still not so good as the effect of proportioning described in test group, shows, using the drug ratio shown in test group, can make in four tastes
Medicine preferably plays the effect that it improves the health care of sleep, and realizes that dose is few, low cost and the significant effect of effect.
Experimental example 2
Barbital sodium Sleep latency is tested
Take mice 40, male and female half and half, after weighing, be randomly divided into 4 groups, every group 10, animal is weighed daily, and presses
2.0ml/100g the oral gavage of body weight, continuous 30 days.Blank group daily gavage distilled water, the test group daily gavage present invention is implemented
The tablet suspension of example 1 preparation, the Radix Panacis Quinquefolii solution of contained Radix Panacis Quinquefolii equivalent, contrast groups in the daily gavage of Radix Panacis Quinquefolii group and tablet
The suspension of the tablet in daily gavage comparative example 1-4, continuous 30 days.After last gavage 15min, to each group animal abdominal cavity note
Penetrate 280mg/kg bw barbital sodium, injection volume is 0.2ml/20g bw, with righting reflex loss as index, observe given the test agent
Impact to barbital sodium Sleep latency, experimental result is shown in Table 2.
Table 2: experimental result
Note: * represents has significant difference, p < 0.05 compared with blank group；
* represents has significant difference, p < 0.01 compared with blank group；
Represent and there is compared with Radix Panacis Quinquefolii group significant difference, p < 0.05；
Represent and there is compared with test group significant difference, p < 0.05.
Test result indicate that, compared with blank group, test group and each contrast groups are respectively provided with preferable shortening mice barbital
The effect of sodium Sleep latency, and there is significant difference, show Semen Ziziphi Spinosae extract, Rhizoma Gastrodiae extract fleece-flower root rattan extract
There is the function of promoting to fall asleep.
, compared with Radix Panacis Quinquefolii group, test group time for falling asleep is shorter for test group, and be in significant difference, each contrast groups with the West
Ginseng group is compared, and mice time for falling asleep is shorter, and assumes significant difference, shows Semen Ziziphi Spinosae extract, Rhizoma Gastrodiae extract fleece-flower root
Rattan extract is compounded with Radix Panacis Quinquefolii, can preferably shorten mice barbital sodium Sleep latency, shows to exempt from by improving body
Epidemic disease power can improve the health care of sleep further.
Experimental result in conjunction with each contrast groups and test group is it is seen that the shortening mice barbital sodium sleep latency of each contrast groups
Compared with test group, test group has the more preferable effect shortening mice barbital sodium Sleep latency, and presents for the effect of phase
Significant difference；The effect of the shortening mice barbital sodium Sleep latency of comparative example 1-4 is more or less the same, and shows by adding relatively
The Radix Panacis Quinquefolii of volume can compensate for the function of Rhizoma Gastrodiae/Caulis Polygoni Multiflori, you can to improve insomnia by improving immunity of organisms auxiliary, but
Improve the effect that insomnia effect is still not so good as proportioning described in test group, show, using the drug ratio shown in test group, four can be made
Taste Chinese medicine preferably plays the effect that it improves the health care of sleep, and realizes that dose is few, low cost and the significant effect of effect.
Experimental example 3
Trial population group 50, contrast groups 50, Radix Panacis Quinquefolii group 50, tested crowd meets following standard:
1) age: 18-70 one full year of life, men and women.
2) difficulty falling asleep, the length of one's sleep is too short, and night is easily awake, the person of having difficulty in going to sleep after waking up.
Observed using double-blind method, test group takes the tablet of the embodiment of the present invention 1 preparation, contrast groups take comparative example 1
Agent, Radix Panacis Quinquefolii group takes the tablet that American Ginseng powder is made, and 2 times a day, and 3 tablets once, continuously takes 4 weeks, simultaneously to medication four
Examination trencherman after week carries out Pittsburgh Sleep scale detection, and insomnia total mark reduces 95% and thinks clinical recovery, loses
Dormancy symptom total mark reduces 30% and thinks effective, and 70% thinks significantly effective, < thinks invalid, according to meter for 30%
Calculate result, count the therapeutic effect of each administration group, experimental result is shown in Table 3, and computing formula is as follows.
Table 3: Insomnia therapy effect statistical result
Test result indicate that, test group and contrast groups 1, the total effective rate up to more than 80% to sleep improvement, this formula
There is the function of preferably improving the health care of sleep.Radix Panacis Quinquefolii group also has some improvement function (>=50%), further demonstrates that by carrying
High immunity of organisms energy remote-effects insomnia.
Claims (10)
1. a kind of improve simultaneously immunity of organisms and sleep compositionss it is characterised in that said composition includes following weight portion
Raw material composition:
6～13 parts of Radix Panacis Quinquefolii, 20～35 parts of Semen Ziziphi Spinosae extract, 20～35 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 20～35
Part.
2. the compositionss simultaneously improving immunity of organisms and sleep according to claim 1 are it is characterised in that said composition
Raw material including following weight portion forms:
8～12 parts of Radix Panacis Quinquefolii, 26～34 parts of Semen Ziziphi Spinosae extract, 26～34 parts of Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract 26～34
Part.
3. the compositionss simultaneously improving immunity of organisms and sleep according to claim 1 are it is characterised in that said composition
Raw material including following weight portion forms:
10 parts of Radix Panacis Quinquefolii, 30 parts of Semen Ziziphi Spinosae extract, 30 parts of Rhizoma Gastrodiae extract, 30 parts of Caulis Polygoni Multiflori extract.
4. the compositionss simultaneously improving immunity of organisms and sleep according to claim 1 are it is characterised in that described west
Total saponin content >=2.5wt% in Radix Panacis Quinquefolii extract；
Preferably, total saponin content >=2.2wt% in described Semen Ziziphi Spinosae extract；
Preferably, stilbene glucoside content >=0.2wt% in described Caulis Polygoni Multiflori extract；
Preferably, gastrodin content >=1.0wt% in described Rhizoma Gastrodiae extract.
5. a kind of improve simultaneously immunity of organisms and sleep health food, with described in any one of claim 1-4 can be simultaneously
Improving immunity of organisms and the compositionss of sleep is effective ingredient, adds pharmaceutic adjuvant, makes tablet, granule or capsule,
The addition of pharmaceutic adjuvant accounts for effective ingredient and the 16-25% of pharmaceutic adjuvant gross weight.
6. health food according to claim 5 is it is characterised in that described pharmaceutic adjuvant is diluent, binding agent, collapses
Solution agent and correctivess, effective ingredient and pharmaceutic adjuvant make tablet through pelletize, tabletting.
7. health food according to claim 6 is it is characterised in that the addition of diluent, binding agent and disintegrating agent accounts for
The 15-22% of total weight of tablet, the addition of correctivess accounts for the 0.5-2% of total weight of tablet；
Preferably, described diluent is potato starch, and binding agent and disintegrating agent are Microcrystalline Cellulose, diluent, bonding
Agent, the mass ratio of disintegrating agent are 3:1:1～1:3:3, and correctivess are the mixture of aspartame, citric acid and orange flavor, Ah
This Ba Tian is 1:1～1:2 with the mass ratio of citric acid, and the addition of orange flavor accounts for the 0.5-1% of tablet total amount.
8. health food according to claim 6, it is characterised in that described tablet, also includes lubricant, lubricant
Addition accounts for the 1-3% of total weight of tablet, and described lubricant is magnesium stearate.
9. the preparation method of the tablet described in any one of claim 6-8, comprises the following steps that
1) Semen Ziziphi Spinosae extract, Rhizoma Gastrodiae extract, Caulis Polygoni Multiflori extract and Radix Panacis Quinquefolii were pulverized 60-80 mesh sieve respectively, by joining
Than weighing screened material respectively, mix homogeneously obtains mixed material powder；
2) press amount ratio and add diluent, binding agent and disintegrating agent, mix homogeneously in above-mentioned mixed material powder, obtain mixture
Material；
3) mixed material is heated pelletize, first mix 5～15 minutes, when pelletize leaving air temp reaches 30～60 DEG C, spray ethanol
Solution, drying at 50～80 DEG C makes material moisture control in below 5.0wt%, then crosses 14～20 mesh sieves and carries out granulate；
4) by step 3) granule after granulate adds correctivess and mix lubricant 10-15 minute, and tabletting is obtained and can improve simultaneously
Immunity of organisms and the tablet of sleep.
10. according to claim 9 the preparation method of tablet it is characterised in that step 3) in the concentration of ethanol solution be 70
～90wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610703187.0A CN106360716A (en) | 2016-08-22 | 2016-08-22 | Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610703187.0A CN106360716A (en) | 2016-08-22 | 2016-08-22 | Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106360716A true CN106360716A (en) | 2017-02-01 |
Family
ID=57878624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610703187.0A Pending CN106360716A (en) | 2016-08-22 | 2016-08-22 | Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106360716A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106880004A (en) * | 2017-02-10 | 2017-06-23 | 天津金匮堂生物科技有限公司 | One kind improves the health care of sleep honey product and preparation method thereof |
| CN114344414A (en) * | 2022-01-29 | 2022-04-15 | 甘肃朴森药业有限公司 | Traditional Chinese medicine composition for soothing nerves and helping sleep as well as preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309565A (en) * | 2011-09-16 | 2012-01-11 | 刘德胜 | Traditional Chinese medicine composition for improving sleep and preparation method thereof |
| CN103584091A (en) * | 2013-10-22 | 2014-02-19 | 无锡市天赐康生物科技有限公司 | Health-care food capable of improving immunity and reducing blood fat and preparation method thereof |
| CN104147394A (en) * | 2014-08-27 | 2014-11-19 | 中国科学院昆明植物研究所 | Dendrobium candidum compound preparation and preparation method thereof |
| CN104189133A (en) * | 2014-08-12 | 2014-12-10 | 安徽衡济堂灵芝产业开发有限公司 | Traditional Chinese medicine capsule capable of improving sleeping and preparation method thereof |
| CN105055855A (en) * | 2015-08-13 | 2015-11-18 | 雷允上药业有限公司 | Traditional Chinese medicine composition having sleep improvement and immunity boost effects as well as preparation method and application of traditional Chinese medicine composition |
| CN105596605A (en) * | 2016-01-28 | 2016-05-25 | 蓬莱海洋（山东）股份有限公司 | Composition with bowel relaxing and sleep improving functions and preparation method thereof |
-
2016
- 2016-08-22 CN CN201610703187.0A patent/CN106360716A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309565A (en) * | 2011-09-16 | 2012-01-11 | 刘德胜 | Traditional Chinese medicine composition for improving sleep and preparation method thereof |
| CN103584091A (en) * | 2013-10-22 | 2014-02-19 | 无锡市天赐康生物科技有限公司 | Health-care food capable of improving immunity and reducing blood fat and preparation method thereof |
| CN104189133A (en) * | 2014-08-12 | 2014-12-10 | 安徽衡济堂灵芝产业开发有限公司 | Traditional Chinese medicine capsule capable of improving sleeping and preparation method thereof |
| CN104147394A (en) * | 2014-08-27 | 2014-11-19 | 中国科学院昆明植物研究所 | Dendrobium candidum compound preparation and preparation method thereof |
| CN105055855A (en) * | 2015-08-13 | 2015-11-18 | 雷允上药业有限公司 | Traditional Chinese medicine composition having sleep improvement and immunity boost effects as well as preparation method and application of traditional Chinese medicine composition |
| CN105596605A (en) * | 2016-01-28 | 2016-05-25 | 蓬莱海洋（山东）股份有限公司 | Composition with bowel relaxing and sleep improving functions and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106880004A (en) * | 2017-02-10 | 2017-06-23 | 天津金匮堂生物科技有限公司 | One kind improves the health care of sleep honey product and preparation method thereof |
| CN114344414A (en) * | 2022-01-29 | 2022-04-15 | 甘肃朴森药业有限公司 | Traditional Chinese medicine composition for soothing nerves and helping sleep as well as preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102078520B (en) | Chinese medicinal preparation for treating nervous headache and preparation method thereof | |
| CN103263608B (en) | Chinese medicinal raw powder for detoxifying and beautifying | |
| CN103784611A (en) | Composition capable of improving sleep and relieving pressure and application thereof | |
| CN103877263B (en) | A kind of antifatigue health preparation of the compound Chinese medicine such as red ginseng, maca, green-tea extract (theanine) | |
| CN103860969A (en) | Traditional Chinese medicine for increasing weight | |
| CN101357136A (en) | Composition of traditional Chinese medicine effective constituent for preventing and treating diseased associated with cerebral ischemia injury | |
| CN105031517A (en) | Dendrobium officinale healthcare tea capable of reducing blood fat, blood sugar, and blood pressure and preparation method thereof | |
| CN103169787B (en) | Composition with functions of improving sleep quality and extending deep sleep time and application thereof | |
| CN104223297B (en) | A kind of schisandra chinensis health-care oral liquid of slow down aging and preparation method thereof | |
| CN107188984B (en) | Polysaccharide composition and preparation method and application thereof | |
| CN103142848B (en) | Anti-aging Chinese medicine preparation and preparation method thereof | |
| CN106360716A (en) | Traditional Chinese medicinal composition for improving body immunity and sleep, and preparation method thereof | |
| KR20160000695A (en) | Herbal-medicine containing dha for recovering fatigue and enhancing memory, and method of manufacturing the same | |
| CN102357151B (en) | Chinese medicinal composition for delaying senility and preparation process thereof | |
| CN105796845A (en) | Application of medicine composition in preparing medicine for treating female climacteric syndromes | |
| CN105030858A (en) | Cynomorium songaricum healthcare tablet and preparation method thereof | |
| CN102784230B (en) | Pharmaceutical composition preparation for treating nutritional anemia | |
| CN112316066B (en) | Jasmine flower-containing traditional Chinese medicine brown sugar capable of soothing nerves and helping sleep and preparation method thereof | |
| CN103463456A (en) | Traditional Chinese medicine composition and preparation method thereof | |
| CN108452193B (en) | Ginseng-medlar original-nourishing wine and preparation method thereof | |
| CN105362630A (en) | Climacteric syndrome treatment pharmaceutical composition and preparation method thereof | |
| CN114081171A (en) | Functional food composition with function of assisting in improving sleep | |
| CN105833043A (en) | Application of traditional Chinese medicine composition in preparation of medicine for treating primary hypertension | |
| CN105362629A (en) | Female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae and preparation method of female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae | |
| CN105853766A (en) | Purpose of traditional Chinese medicinal preparation for preparing medicine for treating primary hypertension |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170201 |
|
| RJ01 | Rejection of invention patent application after publication |