CN104274692A - Jinfo nerve calming liquor and preparation process thereof - Google Patents
Jinfo nerve calming liquor and preparation process thereof Download PDFInfo
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- CN104274692A CN104274692A CN201410324171.XA CN201410324171A CN104274692A CN 104274692 A CN104274692 A CN 104274692A CN 201410324171 A CN201410324171 A CN 201410324171A CN 104274692 A CN104274692 A CN 104274692A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention provides Jinfo nerve calming liquor. The liquor is prepared from crude medicines and auxiliary materials acceptable in the Science of Chinese Pharmacology, wherein the auxiliary materials acceptable in the Science of Chinese Pharmacology comprise liquor and sweetening agents; the crude medicines comprise manyprickle acathopanax root, salvia miltiorrhiza, rhizoma polygonati, atractylodes macrocephala and Chinese magnoliavine fruit. The medicinal liquor can be used for calming the nerves and improving the insomnia symptoms, and the like. Besides, the invention also provides a preparation method of the medicinal liquor.
Description
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of Traditional Chinese medicinal liquor, it has the effect of calming the nerves, and can be used for treatment of insomnia patients etc.
Background technology
Development in thousand gone through by Chinese medicine, theoretical of extensive knowledge and profound scholarship, advocates wholistic therapy, concerted application of drugs.Namely distinguished by " four natures and five flavors of drug " according to the property of medicine of medicine, simultaneously again according to disease return through principle, also returning of Chinese medicine is come through difference.The pharmacist of Chinese medicine list simply according to disease or number taste to the medicable medicine of symptom, and return through the property of medicine such as, the five tastes four gas in addition primary and secondary compatibility with reference to these medicines, namely what is often called monarch, thus the Chinese herbal medicine prescription developing magical curative effect is come.Wherein, golden Buddhist wine is exactly a kind of representative.
Gold Buddhist wine is the Chinese medicine tincture of Traditional Chinese medicine historical preparation standard WS3-B-1157-92, the crude drug that its formula comprises has Fructus Citri Sarcodactylis, Rhizoma Polygonati, Radix Salviae Miltiorrhizae and the Rhizoma Atractylodis Macrocephalae, then use these crude drug powder of soaking in Chinese liquor and percolation collection, then add sugarcane sugar and starch, obtain the medicated wine of 30 ~ 37 degree.This medicated wine has resolving depression of regulating the flow of vital energy, the chest stuffiness relieving is invigorated blood circulation, the effect of stomach invigorating of nourishing blood, and is used for the treatment of the diseases such as the vexed rib of gastral cavity is swollen, loss of appetite, poor sleep.
But, through the present inventor for a long time to traditional theory and the modern pharmacy of Chinese medicine, the research and practice of the different field such as pharmaceutics, find that the effective ingredient of Fructus Citri Sarcodactylis needs could effectively play in compared with the wine of high alcohol content, not good for compliance a large amount of patient being unequal to capacity for liquor, and the present inventor obtains unexpectedly new Traditional Chinese medicinal liquor, have adjusted part crude drug kind, especially principal agent Fructus Citri Sarcodactylis is removed, significantly change crude drug proportioning, monarch relation significantly changes, effect of calming the nerves of medicated wine is significantly improved, be specially adapted to the more effectively treatment of insomnia, and this medicated wine can play drug effect with the wine being low to moderate 18 degree, patient's subject range is wider.Especially surprisingly, the present inventor, by the adjustment to adjuvant, can improve the curative effect of insomnia further.In addition, the present inventor has also found out the preparation technology of this medicated wine, is particularly suitable for large-scale production.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition, it is medicated wine, and it has the effect of calming the nerves, and can be used for treatment of insomnia patients etc.In addition, the present invention also aims to the preparation method and application etc. that this medicated wine is provided.
Specifically, in first aspect, the invention provides golden Buddhist sedative wine, it is made up of adjuvant acceptable on crude drug and Chinese materia medica, and on described Chinese materia medica, acceptable adjuvant comprises wine and sweeting agent, described crude drug and weight portion as follows:
Radix Et Caulis Acanthopanacis Senticosi 40 ~ 60 parts, Radix Salviae Miltiorrhizae 40 ~ 60 parts, Rhizoma Polygonati 24 ~ 36 parts, the Rhizoma Atractylodis Macrocephalae 16 ~ 24 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts.
In this article, Radix Et Caulis Acanthopanacis Senticosi, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and Fructus Schisandrae Chinensis are and can buy by market channel the crude drug (traditional Chinese medicinal material raw materials) obtained.Although some another name or different name, those skilled in the art can buy corresponding crude drug by above-mentioned title completely.
Preferably in the golden Buddhist sedative wine of first aspect present invention, described crude drug and weight portion as follows:
Radix Et Caulis Acanthopanacis Senticosi 45 ~ 55 parts, Radix Salviae Miltiorrhizae 45 ~ 55 parts, Rhizoma Polygonati 27 ~ 33 parts, the Rhizoma Atractylodis Macrocephalae 18 ~ 22 parts, Fructus Schisandrae Chinensis 9 ~ 11 parts.
More preferably in the golden Buddhist sedative wine of first aspect present invention, described crude drug and weight portion as follows:
Radix Et Caulis Acanthopanacis Senticosi 50 parts, Radix Salviae Miltiorrhizae 50 parts, Rhizoma Polygonati 30 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Schisandrae Chinensis 10 parts.
Also preferably the golden Buddhist sedative wine of first aspect present invention is prepared by the following method:
(1) pulverize and mix Radix Et Caulis Acanthopanacis Senticosi, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and Fructus Schisandrae Chinensis, obtaining crude drug powder:
(2) soak crude drug powder with the wine of alcohol by volume content 45 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 45 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 15 ~ 36%, more preferably 16-29%, as 18%) leave standstill clarification.
The usual expenditure of alcohol by volume content in wine or " ° " represent, the ethanol number of degrees as the wine of alcohol by volume content 50% are 50 degree.Preferably in this article, wine is Chinese liquor.Also preferred in the golden Buddhist sedative wine of first aspect present invention, (namely each preparation process adds up and the final alcoholic liquid part produced after optional dilution the wine in acceptable adjuvant; In the wine of final 18 degree, the wine of other number of degrees can convert) be 800 ~ 1200: 40 ~ 60 (L/kg) with the volume mass ratio of the Radix Et Caulis Acanthopanacis Senticosi in crude drug, preferably 900 ~ 1100: 45 ~ 55 (L/kg), are most preferably 1000: 50 (L/kg).
Gold Buddhist wine needs the drug effect playing Fructus Citri Sarcodactylis in the wine compared with high alcohol content number, but the large usage quantity needed for the onset of golden Buddhist wine, comparatively high alcohol content number will cause some patients not feel well owing to being unequal to capacity for liquor.Golden Buddhist sedative wine of the present invention overcomes such defect, can play drug effect with the lower ethanol number of degrees.The alcohol by volume content of the golden Buddhist sedative wine of first aspect present invention is less than the alcohol by volume content of golden Buddhist wine, as being less than 30 ~ 37%.The golden Buddhist sedative wine of preferred first aspect present invention is the medicated wine of alcohol by volume content 15 ~ 36%, more preferably the golden Buddhist sedative wine of first aspect present invention is the medicated wine of alcohol by volume content 16 ~ 29%, in the specific embodiment of the present invention, the golden Buddhist sedative wine of first aspect present invention is the medicated wine of alcohol by volume content 18%.
Also preferred in the golden Buddhist sedative wine of first aspect present invention, sweeting agent is sucrose or non-sucrose sweetener.In the specific embodiment of the present invention, be no matter sucrose as sweeting agent, be also non-sucrose sweetener as sweeting agent, the combination drug effect of crude drug composition can be kept, can be used for calming the nerves and treatment of insomnia patients.But, surprisingly, non-sucrose sweetener, the sweeting agent of especially allotment meticulously in the specific embodiment of the invention, although maintain almost with add the same mouthfeel of sucrose, for the drug effect for the treatment of of insomnia patients but than employing sucrose significantly improving as sweeting agent.Its mechanism we also among further research, but do not limit by theoretical, more preferably in the golden Buddhist sedative wine of first aspect present invention, sweeting agent is non-sucrose sweetener, as isomaltulose, xylitol, stevioside, Momordica-Glycosides and/or erythrose.
In the specific embodiment of the present invention, sweeting agent comprises isomaltulose, xylitol and stevioside, is preferably made up of isomaltulose, xylitol and stevioside.More preferably in the golden Buddhist sedative wine of first aspect present invention, isomaltulose, xylitol and stevioside and weight portion as follows:
Maltulose 32 ~ 48 parts (preferably 36 ~ 44 parts, as 40 parts), xylitol 20 ~ 30 parts (preferably 22.5 ~ 27.5 parts, as 25 parts), stevioside 0.08 ~ 0.12 part (preferably 0.09 ~ 011 part, as 0.1 part).
Preferred in addition in the golden Buddhist sedative wine of first aspect present invention, the mass ratio of maltulose and Radix Et Caulis Acanthopanacis Senticosi is 32 ~ 48: 40 ~ 60, and being preferably 36 ~ 44: 45 ~ 55, is most preferably 1000: 50.
In second aspect, the invention provides the preparation method of the golden Buddhist sedative wine of first aspect present invention, it comprises,
(1) pulverize and mix Radix Et Caulis Acanthopanacis Senticosi, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and Fructus Schisandrae Chinensis, obtaining crude drug powder:
(2) soak crude drug powder with the wine of alcohol by volume content 45 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 45 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 15 ~ 36%, more preferably 16-29%, as 18%) leave standstill clarification.
In the preparation method of second aspect present invention, can each preferred feature of preferred first aspect present invention, only otherwise produce contradiction.In addition, preferably in the preparation method of second aspect present invention, wine in step (2) is (in the wine of 50 degree, the wine of other number of degrees can convert) be 200 ~ 300: 40 ~ 60 (L/kg) with the volume mass ratio of the Radix Et Caulis Acanthopanacis Senticosi in crude drug, preferably 225 ~ 275: 45 ~ 55 (L/kg), are most preferably 250: 50 (L/kg).Preferably in the preparation method of second aspect present invention, the amount of the wine in step (3) is subject to the ethanol number of degrees restriction of the final golden Buddhist sedative wine obtained.
Till the preparation method of second aspect present invention can proceed to step (4), but the golden Buddhist sedative wine ethanol number of degrees obtained are higher, are not suitable for taking of more extensive patients colony, therefore preferred also further implementation step (5).
In the third aspect, the golden Buddhist sedative wine that the invention provides first aspect present invention for the preparation of calm the nerves and treatment of insomnia patients medicine in application.Wherein, the golden Buddhist sedative wine preferably providing first aspect present invention is for the preparation of the application in the medicine for the treatment of of insomnia patients.
Beneficial effect of the present invention is, the medicated wine ethanol number of degrees of the present invention are lower, can improve the compliance that patient takes; Medicated wine of the present invention can be effective to calm the nerves and treatment of insomnia patients etc., the especially determined curative effect for the treatment of of insomnia patients; Medicated wine of the present invention can improve unexpectedly the curative effect for the treatment of of insomnia patients further after adjuvant improves; The preparation method of medicated wine of the present invention is easy, is convenient to standardization and quality control, is applicable to large-scale production.
For the ease of understanding, below will present invention is described by specific embodiment.It is important to note that these descriptions are only exemplary descriptions, do not form limitation of the scope of the invention.
Detailed description of the invention
Formula of medicated wine of the present invention and preparation method thereof is set forth further below by example, but the scope do not limited the present invention in any way.
The preparation of embodiment 1 medicated wine
Get 5kg Radix Et Caulis Acanthopanacis Senticosi, 5kg Radix Salviae Miltiorrhizae, 3kg Rhizoma Polygonati, the 2kg Rhizoma Atractylodis Macrocephalae and 1kg Fructus Schisandrae Chinensis, be ground into the coarse powder crossing 120 mesh sieves respectively, mix homogeneously, namely obtain crude drug powder.Getting 25L50 degree Chinese liquor adds in above-mentioned crude drug powder, after stirring, places 8 days in room temperature (about 25 DEG C), period every other day stirs once, filters after expiring, and filters and proceeds to finally extrude medicinal residues, to squeeze out the liquid in medicinal residues, thus fully obtain filtrate.Get the medicinal residues of 12L50 degree Chinese liquor percolation by above-mentioned extruding further, collect percolate, and mix with above-mentioned filtrate, then leave standstill one day in room temperature, filter, obtain clear liquor.Isomaltulose 4kg, xylitol 2.5kg and the stevioside 10g by a small amount of dissolved in purified water is added to above-mentioned clear liquor, after mix homogeneously, add pure water (if desired, if abovementioned steps loss is comparatively large, a small amount of 50 degree of Chinese liquor also can be added) be diluted to 100L, wherein the ethanol number of degrees are 18 degree, 120 hours are left standstill in 5 DEG C of cold preservations, filter, obtain the preferred golden Buddhist sedative wine (medicated wine 1) of the present invention, subpackage medicated wine 125mL/ bottle.
Basic repetition said process, difference is that sweeting agent 8kg sucrose replaces, and preparation cost invents general golden Buddhist sedative wine (medicated wine 2).Medicated wine 1 is substantially identical with the taste of medicated wine 2.
Get 50 degree of Chinese liquor and be diluted to 18 degree of Chinese liquor, in contrast 1; Produce golden Buddhist wine according to Traditional Chinese medicine historical preparation standard WS3-B-1157-92, wherein the ethanol number of degrees are 33 degree, in contrast 2.
The clinical trial of embodiment 2 Cure for insomnia
65 insomniacs are divided into 4 groups at random, the patient often organized respectively at during dinner every day oral prepare according to method described in embodiment 1 medicated wine 1, medicated wine 2, contrast 1 and contrast 2, each serving with 100mL, 7 days courses for the treatment of.Carry out 1 post-evaluation course for the treatment of to the effect of Insomnia therapy, wherein contrasting in 1 group has 1 patient to represent to be not suitable with Chinese liquor taste and finally not complete this course for the treatment of, there are 3 patients to represent due to discomfort of drinking in matched group 2, also finally do not complete this course for the treatment of, reject the data of these patients; The patient of other groups all completes this course for the treatment of.The evaluation criterion of curative effect is as follows:
Recovery from illness: more than 6 hours continuous length of one's sleep of night;
Effective: more than when the continuous length of one's sleep in night is less than the front increase by 3 for the treatment of;
Effective: the continuous length of one's sleep in night increases than before treatment, but less than 3 hours;
Invalid: the continuous length of one's sleep in night does not increase than before treatment, even reduces.
Effect after each group for the treatment of is as shown in table 1, due to the taste of Chinese liquor and the limitation of ethanol number of degrees adaptation population, therefore the patient's compliance contrasting 1 and 2 (especially the latter) is not good, and medicated wine of the present invention all effectively overcomes this defect, and respective patient is completed whole course for the treatment of; Relative to contrast 1, medicated wine and two kinds of medicated wine of the present invention of contrast 2 all greatly improve total effective rate, especially be greatly improve cure rate and obvious effective rate, wherein the medicated wine of contrast 2 is substantially identical with the curative effect of medicated wine 2 of the present invention, but unexpectedly, improvement only on adjuvant sweeting agent, causes medicated wine 1 of the present invention significantly to improve than medicated wine 2 and the total effective rate and cure rate contrasting 2, illustrates that medicated wine 1 of the present invention is more preferably.
Table 1 Insomnia therapy effectiveness comparison
Claims (10)
1. gold Buddhist sedative wine, it is made up of adjuvant acceptable on crude drug and Chinese materia medica, and on described Chinese materia medica, acceptable adjuvant comprises wine and sweeting agent, described crude drug and weight portion as follows:
Radix Et Caulis Acanthopanacis Senticosi 40 ~ 60 parts, Radix Salviae Miltiorrhizae 40 ~ 60 parts, Rhizoma Polygonati 24 ~ 36 parts, the Rhizoma Atractylodis Macrocephalae 16 ~ 24 parts, Fructus Schisandrae Chinensis 8 ~ 12 parts.
2. golden Buddhist sedative wine according to claim 1, wherein said crude drug and weight portion as follows:
Radix Et Caulis Acanthopanacis Senticosi 45 ~ 55 parts, Radix Salviae Miltiorrhizae 45 ~ 55 parts, Rhizoma Polygonati 27 ~ 33 parts, the Rhizoma Atractylodis Macrocephalae 18 ~ 22 parts, Fructus Schisandrae Chinensis 9 ~ 11 parts.
3. golden Buddhist sedative wine according to claim 2, wherein said crude drug and weight portion as follows:
Radix Et Caulis Acanthopanacis Senticosi 50 parts, Radix Salviae Miltiorrhizae 50 parts, Rhizoma Polygonati 30 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Schisandrae Chinensis 10 parts.
4. golden Buddhist sedative wine according to claim 1, it is prepared by the following method:
(1) pulverize and mix Radix Et Caulis Acanthopanacis Senticosi, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and Fructus Schisandrae Chinensis, obtaining crude drug powder;
(2) soak crude drug powder with the wine of alcohol by volume content 45 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 45 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 15 ~ 36%, more preferably 16-29%, as 18%) leave standstill clarification.
5. golden Buddhist sedative wine according to claim 1, wherein sweeting agent is sucrose or non-sucrose sweetener, is preferably non-sucrose sweetener, as isomaltulose, xylitol, stevioside, Momordica-Glycosides and/or erythrose.
6. golden Buddhist sedative wine according to claim 5, wherein sweeting agent comprises isomaltulose, xylitol and stevioside, is preferably made up of isomaltulose, xylitol and stevioside.
7. golden Buddhist sedative wine according to claim 6, wherein isomaltulose, xylitol and stevioside and weight portion as follows:
Maltulose 32 ~ 48 parts (preferably 36 ~ 44 parts, as 40 parts), xylitol 20 ~ 30 parts (preferably 22.5 ~ 27.5 parts, as 25 parts), stevioside 0.08 ~ 0.12 part (preferably 0.09 ~ 011 part, as 0.1 part).
8. golden Buddhist sedative wine according to claim 1, it is the medicated wine of alcohol by volume content 15 ~ 25% (as 18%).
9. the preparation method of golden Buddhist sedative wine according to claim 1, it comprises,
(1) pulverize and mix Radix Et Caulis Acanthopanacis Senticosi, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, the Rhizoma Atractylodis Macrocephalae and Fructus Schisandrae Chinensis, obtaining crude drug powder;
(2) soak crude drug powder with the wine of alcohol by volume content 45 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 45 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 15 ~ 36%, more preferably 16-29%, as 18%) leave standstill clarification.
10. the arbitrary described golden Buddhist sedative wine of claim 1 ~ 8 is for the preparation of the application in the medicine for the treatment of of insomnia patients.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104694354A (en) * | 2015-03-20 | 2015-06-10 | 吉林大学 | Anti-fatigue health care wine and preparing method thereof |
| CN104694357A (en) * | 2015-03-20 | 2015-06-10 | 吉林大学 | Ginseng healthcare wine for boosting immunity and preparation method thereof |
| CN104694355A (en) * | 2015-03-20 | 2015-06-10 | 吉林大学 | Puerarin liver protection health care wine and preparation method thereof |
| CN104840967A (en) * | 2015-05-13 | 2015-08-19 | 上海中医药大学 | Taste correction method for oral liquid preparation of traditional Chinese medicine containing ethyl alcohol |
| CN105861254A (en) * | 2016-05-03 | 2016-08-17 | 广西慧宝源制药有限公司 | Precipitate removal method for Jinfo liquor production |
| CN110215494A (en) * | 2019-06-24 | 2019-09-10 | 广州中医药大学(广州中医药研究院) | A kind of Chinese medicinal granule and preparation method thereof adjusting sleep |
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