CN104274602A - Liquor capable of dredging collaterals and protecting kidneys and preparation process thereof - Google Patents
Liquor capable of dredging collaterals and protecting kidneys and preparation process thereof Download PDFInfo
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- CN104274602A CN104274602A CN201410323560.0A CN201410323560A CN104274602A CN 104274602 A CN104274602 A CN 104274602A CN 201410323560 A CN201410323560 A CN 201410323560A CN 104274602 A CN104274602 A CN 104274602A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 49
- 229940079593 drug Drugs 0.000 claims abstract description 33
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 18
- 206010022437 insomnia Diseases 0.000 claims abstract description 18
- 239000009636 Huang Qi Substances 0.000 claims abstract description 17
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- 235000003599 food sweetener Nutrition 0.000 claims abstract description 7
- 239000003765 sweetening agent Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 17
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- 239000000843 powder Substances 0.000 claims description 12
- 239000005720 sucrose Substances 0.000 claims description 12
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 11
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 11
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 11
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 11
- 235000019202 steviosides Nutrition 0.000 claims description 11
- 235000010447 xylitol Nutrition 0.000 claims description 11
- 239000000811 xylitol Substances 0.000 claims description 11
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 11
- 229960002675 xylitol Drugs 0.000 claims description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- PVXPPJIGRGXGCY-TZLCEDOOSA-N 6-O-alpha-D-glucopyranosyl-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 PVXPPJIGRGXGCY-TZLCEDOOSA-N 0.000 claims description 9
- 241001620634 Roger Species 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 8
- 238000005352 clarification Methods 0.000 claims description 8
- 238000005325 percolation Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000002398 materia medica Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- NBGXQZRRLOGAJF-UHFFFAOYSA-N Maltulose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)(CO)OCC1O NBGXQZRRLOGAJF-UHFFFAOYSA-N 0.000 claims description 3
- JCQLYHFGKNRPGE-HFZVAGMNSA-N maltulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-HFZVAGMNSA-N 0.000 claims description 3
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- YTBSYETUWUMLBZ-IUYQGCFVSA-N D-erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 claims description 2
- 206010056474 Erythrosis Diseases 0.000 claims description 2
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- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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Abstract
The invention provides liquor capable of dredging collaterals and protecting kidneys. The liquor is prepared from crude medicines and auxiliary materials acceptable in the Science of Chinese Pharmacology, wherein the auxiliary materials acceptable in the Science of Chinese Pharmacology comprise liquor and sweetening agents; the crude medicines comprise radix astragali, black ants, barbary wolfberry fruit, desertliving cistanche and epimedium herb. The medicinal liquor can be used for removing pain, calming the nerves and improving the insomnia symptoms, and the like. Besides, the invention also provides a preparation method of the medicinal liquor.
Description
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of Traditional Chinese medicinal liquor, it has effect that dredging collateral protects kidney, the pain that can be used for dispelling, calms the nerves and treatment of insomnia patients etc.
Background technology
Development in thousand gone through by Chinese medicine, theoretical of extensive knowledge and profound scholarship, advocates wholistic therapy, concerted application of drugs.Namely distinguished by " four natures and five flavors of drug " according to the property of medicine of medicine, simultaneously again according to disease return through principle, also returning of Chinese medicine is come through difference.The pharmacist of Chinese medicine list simply according to disease or number taste to the medicable medicine of symptom, and return through the property of medicine such as, the five tastes four gas in addition primary and secondary compatibility with reference to these medicines, namely what is often called monarch, thus the Chinese herbal medicine prescription developing magical curative effect is come.Wherein some prescription crude drug kind is a bit similar, but proportioning and drug effect are widely different.
Such as, dredging collateral kidney-tonifying wine is the Chinese medicine tincture of the accurate word B20020587 of traditional Chinese medicines, its formula also appears in No. 200310101139, the Chinese patent after this applied for, the crude drug comprised has Formica fusca, myrtle fruit, the Radix Astragali, Fructus Lycii and Herba Cistanches, then these crude drug powder of soaking in Chinese liquor are used and percolation collection, add sugarcane sugar and starch again, obtain medicated wine.This medicated wine has effect of vigorate qi and replenish the blood, the lumbus strengthening and the kidney invigorating, dredge the meridian passage, expelling wind and removing dampness, can also improve human plasma testosterone concentration, and can improve alopecia symptom.But this medicated wine is calmed the nerves effect not obvious, does not have to point out the treatment being used for insomnia.
But, through the present inventor for a long time to the traditional theory of Chinese medicine and the research and practice of the different field such as modern pharmacy, pharmaceutics, obtain unexpectedly new Traditional Chinese medicinal liquor, have adjusted part crude drug kind, significantly change crude drug proportioning, monarch relation significantly changes, but can on the basis of effect remaining activating meridians to stop pain, make medicated wine have effect of calming the nerves significantly, be specially adapted to the treatment of insomnia.More surprisingly, the present inventor, by the adjustment to adjuvant, improves the curative effect of insomnia further.In addition, the present inventor has also found out the preparation technology of this medicated wine, is particularly suitable for large-scale production.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition, it is medicated wine, and it has effect that dredging collateral protects kidney, the pain that can be used for dispelling, calms the nerves and treatment of insomnia patients etc.In addition, the present invention also aims to the preparation method and application etc. that this medicated wine is provided.
Specifically, in first aspect, the invention provides dredging collateral and protect kidney wine, it is made up of adjuvant acceptable on crude drug and Chinese materia medica, and on described Chinese materia medica, acceptable adjuvant comprises wine and sweeting agent, described crude drug and weight portion as follows:
The Radix Astragali 24 ~ 36 parts, Formica fusca 16 ~ 24 parts, Fructus Lycii 16 ~ 24 parts, Herba Cistanches 16 ~ 24 parts, Herba Epimedii 12 ~ 18 parts.
In this article, the Radix Astragali, Formica fusca, Fructus Lycii, Herba Cistanches and Herba Epimedii are and can buy by market channel the crude drug (traditional Chinese medicinal material raw materials) obtained.Although some another name or different name, those skilled in the art can buy corresponding crude drug by above-mentioned title completely.Preferably in this article, Formica fusca is Polyhachis vicina Roger.
Preferably protect in kidney wine at the dredging collateral of first aspect present invention, described crude drug and weight portion as follows:
The Radix Astragali 27 ~ 33 parts, Formica fusca 18 ~ 22 parts, Fructus Lycii 18 ~ 22 parts, Herba Cistanches 18 ~ 22 parts, Herba Epimedii 13.5 ~ 16.5 parts.
More preferably protect in kidney wine at the dredging collateral of first aspect present invention, described crude drug and weight portion as follows:
The Radix Astragali 30 parts, Formica fusca 20 parts, Fructus Lycii 20 parts, Herba Cistanches 20 parts, Herba Epimedii 15 parts.
Also preferably the dredging collateral of first aspect present invention protects kidney wine and prepares by the following method:
(1) pulverize and mix the Radix Astragali, Formica fusca (preferably Polyhachis vicina Roger), Fructus Lycii, Herba Cistanches and Herba Epimedii, obtaining crude drug powder:
(2) soak crude drug powder with the wine of alcohol by volume content 46 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 46 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 25 ~ 45%, as 30 ~ 37%) leave standstill clarification.
The usual expenditure of alcohol by volume content in wine or " ° " represent, the ethanol number of degrees as the wine of alcohol by volume content 50% are 50 degree.Preferably in this article, wine is Chinese liquor.Also the preferred dredging collateral in first aspect present invention protects in kidney wine, and (namely each preparation process adds up and the final alcoholic liquid part produced after optional dilution the wine in acceptable adjuvant; In the wine of final 30 degree, the wine of other number of degrees can convert) be 800 ~ 1200: 24 ~ 36 (L/kg) with the volume mass ratio of the Radix Astragali in crude drug, preferably 900 ~ 1100: 27 ~ 33 (L/kg), are most preferably 1000: 30 (L/kg).
Also the preferred dredging collateral in first aspect present invention protects in kidney wine, and sweeting agent is sucrose or non-sucrose sweetener.In the specific embodiment of the present invention, be no matter sucrose as sweeting agent, be also non-sucrose sweetener as sweeting agent, the combination drug effect of crude drug composition can be kept, the pain that can be used for dispelling, to calm the nerves and treatment of insomnia patients.But, surprisingly, non-sucrose sweetener, the sweeting agent of especially allotment meticulously in the specific embodiment of the invention, although maintain almost with add the same mouthfeel of sucrose, for the drug effect for the treatment of of insomnia patients but than employing sucrose significantly improving as sweeting agent.Its mechanism we also among further research, but do not limit by theoretical, more preferably protect in kidney wine at the dredging collateral of first aspect present invention, sweeting agent is non-sucrose sweetener, as isomaltulose, xylitol, stevioside, Momordica-Glycosides and/or erythrose.
In the specific embodiment of the present invention, sweeting agent comprises isomaltulose, xylitol and stevioside, is preferably made up of isomaltulose, xylitol and stevioside.More preferably protect in kidney wine at the dredging collateral of first aspect present invention, isomaltulose, xylitol and stevioside and weight portion as follows:
Maltulose 24 ~ 36 parts (preferably 27 ~ 33 parts, as 30 parts), xylitol 16 ~ 24 parts (preferably 18 ~ 22 parts, as 20 parts), stevioside 0.08 ~ 0.12 part (preferably 0.09 ~ 011 part, as 0.1 part).
The preferred dredging collateral in first aspect present invention protects in kidney wine in addition, and the mass ratio of maltulose and the Radix Astragali is 24 ~ 36: 24 ~ 36, and preferably 27 ~ 33: 27 ~ 33 (L/kg), are most preferably 30: 30.
In second aspect, the dredging collateral that the invention provides first aspect present invention protects the preparation method of kidney wine, and it comprises,
(1) pulverize and mix the Radix Astragali, Formica fusca (preferably Polyhachis vicina Roger), Fructus Lycii, Herba Cistanches and Herba Epimedii, obtaining crude drug powder:
(2) soak crude drug powder with the wine of alcohol by volume content 46 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 46 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 25 ~ 45%, as 30 ~ 37%) leave standstill clarification.
In the preparation method of second aspect present invention, can each preferred feature of preferred first aspect present invention, only otherwise produce contradiction.In addition, preferably in the preparation method of second aspect present invention, wine in step (2) is (in the wine of 50 degree, the wine of other number of degrees can convert) be 160 ~ 240: 24 ~ 36 (L/kg) with the volume mass ratio of the Radix Astragali in crude drug, preferably 180 ~ 220: 27 ~ 33 (L/kg), are most preferably 200: 30 (L/kg).Preferably in the preparation method of second aspect present invention, the amount of the wine in step (3) is subject to the ethanol number of degrees restriction that the final dredging collateral obtained protects kidney wine.
Till the preparation method of second aspect present invention can proceed to step (4), but to protect the kidney wine ethanol number of degrees higher for the dredging collateral obtained, and is not suitable for taking of more extensive patients colony, therefore preferred also further implementation step (5).
In the third aspect, the dredging collateral that the invention provides first aspect present invention protect kidney wine for the preparation of pain of dispelling, calm the nerves and treatment of insomnia patients medicine in application.Wherein, the dredging collateral preferably providing first aspect present invention protects kidney wine for the preparation of the application in the medicine for the treatment of of insomnia patients; Also the dredging collateral preferably providing first aspect present invention protects kidney wine for the preparation of the application of dispelling in the medicine of pain.
Beneficial effect of the present invention is, medicated wine of the present invention can be effective to dispel pain, calm the nerves and treatment of insomnia patients etc., the especially determined curative effect for the treatment of of insomnia patients; Medicated wine of the present invention can improve unexpectedly the curative effect for the treatment of of insomnia patients further after adjuvant improves; The preparation method of medicated wine of the present invention is easy, is convenient to standardization and quality control, is applicable to large-scale production.
For the ease of understanding, below will present invention is described by specific embodiment.It is important to note that these descriptions are only exemplary descriptions, do not form limitation of the scope of the invention.
Detailed description of the invention
Formula of medicated wine of the present invention and preparation method thereof is set forth further below by example, but the scope do not limited the present invention in any way.
The preparation of embodiment 1 medicated wine
Get the 3kg Radix Astragali, 2kg Polyhachis vicina Roger, 2kg Fructus Lycii, 2kg Herba Cistanches and 1.5kg Herba Epimedii, be ground into the coarse powder crossing 120 mesh sieves respectively, mix homogeneously, namely obtain crude drug powder.Getting 20L50 degree Chinese liquor adds in above-mentioned crude drug powder, after stirring, places 8 days in room temperature (about 25 DEG C), period every other day stirs once, filters after expiring, and filters and proceeds to finally extrude medicinal residues, to squeeze out the liquid in medicinal residues, thus fully obtain filtrate.Get the medicinal residues of 43L50 degree Chinese liquor percolation by above-mentioned extruding further, collect percolate, and mix with above-mentioned filtrate, then leave standstill one day in room temperature, filter, obtain clear liquor.Isomaltulose 3kg, xylitol 2kg and the stevioside 10g by a small amount of dissolved in purified water is added to above-mentioned clear liquor, after mix homogeneously, add pure water (if desired, if abovementioned steps loss is comparatively large, a small amount of 50 degree of Chinese liquor also can be added) be diluted to 100L, wherein the ethanol number of degrees are 30 degree, 120 hours are left standstill in 5 DEG C of cold preservations, filter, obtain the preferred dredging collateral of the present invention and protect kidney wine (medicated wine 1), subpackage medicated wine 125mL/ bottle.
Basic repetition said process, difference is that sweeting agent 6.5kg sucrose replaces, and preparation cost is invented general dredging collateral and protected kidney wine (medicated wine 2).Medicated wine 1 is substantially identical with the taste of medicated wine 2.
Get 50 degree of Chinese liquor and be diluted to 30 degree of Chinese liquor, in contrast 1; According to the standard production dredging collateral kidney-tonifying wine of the accurate word B20020587 of traditional Chinese medicines, in contrast 2.
The clinical trial of embodiment 2 Cure for insomnia
86 insomniacs are divided into 4 groups at random, the patient often organized respectively at during dinner every day oral prepare according to method described in embodiment 1 medicated wine 1, medicated wine 2, contrast 1 and contrast 2, each serving with 25mL, 8 days courses for the treatment of, stop using 2 days after the course for the treatment of.Carry out 3 post-evaluations course for the treatment of to the effect of Insomnia therapy, wherein contrasting in 1 group has 5 patients to represent to be not suitable with Chinese liquor taste and finally not complete whole course for the treatment of, rejecting the data of these patients; The patient of other groups all completes whole course for the treatment of.The evaluation criterion of curative effect is as follows:
Recovery from illness: more than 6 hours continuous length of one's sleep of night;
Effective: more than when the continuous length of one's sleep in night is less than the front increase by 3 for the treatment of;
Effective: the continuous length of one's sleep in night increases than before treatment, but less than 3 hours;
Invalid: the continuous length of one's sleep in night does not increase than before treatment, even reduces.
Effect after each group for the treatment of is as shown in table 1, and due to the limitation of the taste adaptation population of Chinese liquor, therefore patient's compliance of contrast 1 is not good, and the medicated wine of medicated wine of the present invention and contrast 2 all effectively overcomes this defect, and respective patient is completed whole course for the treatment of; Relative to contrast 1, the medicated wine of contrast 2 does not almost improve the total effective rate of Cure for insomnia, and two kinds of medicated wine of the present invention all greatly improve total effective rate, especially be greatly improve cure rate and obvious effective rate, wherein more unexpectedly be, improvement only on adjuvant sweeting agent, also causes medicated wine 1 of the present invention significantly to improve than the total effective rate of medicated wine 2 and cure rate, illustrates that medicated wine 1 of the present invention is more preferably.
Table 1 Insomnia therapy effectiveness comparison
Embodiment 3 dispel pain therapeutic test
Owing to also not obtaining the clinical trial official written reply of corresponding disease, therefore when informed consent, to there being the trial volunteer of history of drinking history to provide medicated wine of the present invention as follows, and receive the Active report that they drink rear effect:
Patient 1: male, 55 years old, and meeting sitting stands up all to feel that health is felt nervous, and waist was once sprained, and health is difficult to rotate, hurt like hell.Take medicated wine 250mL of the present invention, pain relief after 1 hour, after 4 hours, take 50mL again, recover completely after 12 hours.
Patient 2: women, 46 years old, and work sitting is stood up, and feel lumbar strain suddenly, health is heavy, and be difficult to rotate, pain endlessly.Take medicated wine 250mL of the present invention, pain relief after 2 hours, after 4 hours, take this health promoting wine 50mL again, physical recovery (subjective assessment recovers 80%) after 12 hours.After this, take medicated wine of the present invention every day 22 times, each 50mL, after taking 3 days continuously, report recovery from illness.
Patient 3: male, 60 years old, soreness of the waist and knees, arthralgia, movable difficulty, tired for many years weak.Daily medicated wine of the present invention 11 times, each 100mL, Time of Administration is normally after dinner.After continuing to carry out two weeks, muscle power is obviously recovered, soreness of the waist and knees transference cure, and joint motion is convenient, and pain disappears.
Patient 4: male, 45 years old, and sitting is stood up to dash forward and felt numbness of lower limbs, and waist is prominent to be sprained, and health is difficult to rotate, hurt like hell.Take medicated wine 150mL of the present invention, pain relief after 1 hour, after 4 hours, take 50mL again, recover completely after 12 hours.
Patient 5: women, 56 years old, and waist sprains history, and health is heavy, soreness of the waist and knees.Take medicated wine 1 of the present invention, every day 2 times, each 50mL, feel hale and hearty after continuing to take 60 days, without soreness of the waist and knees symptom.
Patient 6: male, 65 years old, soreness of the waist and knees, qi stagnation blood stasis, tired for many years weak.Daily medicated wine of the present invention 11 times, each 100mL, Time of Administration is normally after dinner.After continuing to carry out six weeks, muscle power is obviously recovered, soreness of the waist and knees transference cure.
Claims (10)
1. dredging collateral protects kidney wine, and it is made up of adjuvant acceptable on crude drug and Chinese materia medica, and on described Chinese materia medica, acceptable adjuvant comprises wine and sweeting agent, described crude drug and weight portion as follows:
The Radix Astragali 24 ~ 36 parts, Formica fusca (preferably Polyhachis vicina Roger) 16 ~ 24 parts, Fructus Lycii 16 ~ 24 parts, Herba Cistanches 16 ~ 24 parts, Herba Epimedii 12 ~ 18 parts.
2. dredging collateral according to claim 1 protects kidney wine, wherein said crude drug and weight portion as follows:
The Radix Astragali 27 ~ 33 parts, Formica fusca (preferably Polyhachis vicina Roger) 18 ~ 22 parts, Fructus Lycii 18 ~ 22 parts, Herba Cistanches 18 ~ 22 parts, Herba Epimedii 13.5 ~ 16.5 parts.
3. dredging collateral according to claim 2 protects kidney wine, wherein said crude drug and weight portion as follows:
The Radix Astragali 30 parts, Formica fusca (preferably Polyhachis vicina Roger) 20 parts, Fructus Lycii 20 parts, Herba Cistanches 20 parts, Herba Epimedii 15 parts.
4. dredging collateral according to claim 1 protects kidney wine, and it is prepared by the following method:
(1) pulverize and mix the Radix Astragali, Formica fusca (preferably Polyhachis vicina Roger), Fructus Lycii, Herba Cistanches and Herba Epimedii, obtaining crude drug powder;
(2) soak crude drug powder with the wine of alcohol by volume content 46 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 46 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 25 ~ 45%, as 30-37%) leave standstill clarification.
5. dredging collateral according to claim 1 protects kidney wine, and wherein sweeting agent is sucrose or non-sucrose sweetener, is preferably non-sucrose sweetener, as isomaltulose, xylitol, stevioside, Momordica-Glycosides and/or erythrose.
6. dredging collateral according to claim 5 protects kidney wine, and wherein sweeting agent comprises isomaltulose, xylitol and stevioside, is preferably made up of isomaltulose, xylitol and stevioside.
7. dredging collateral according to claim 6 protects kidney wine, wherein isomaltulose, xylitol and stevioside and weight portion as follows:
Maltulose 24 ~ 36 parts (preferably 27 ~ 33 parts, as 30 parts), xylitol 16 ~ 24 parts (preferably 18 ~ 22 parts, as 20 parts), stevioside 0.08 ~ 0.12 part (preferably 0.09 ~ 011 part, as 0.1 part).
8. dredging collateral according to claim 1 protects the preparation method of kidney wine, and it comprises,
(1) pulverize and mix the Radix Astragali, Formica fusca (preferably Polyhachis vicina Roger), Fructus Lycii, Herba Cistanches and Herba Epimedii, obtaining crude drug powder;
(2) soak crude drug powder with the wine of alcohol by volume content 46 ~ 60% (as 50%) and filter, obtaining medicinal residues and filtrate;
(3) medicinal residues obtained by step (2) with the wine percolation of alcohol by volume content 46 ~ 60% (as 50%) also collect percolate;
(4) percolate that obtains of the filtrate that obtains of combining step (2) and step (3) after leaving standstill clarification, add sweeting agent; With,
(5) optional dilute with water (being preferably diluted to alcohol by volume content 25 ~ 45%, as 30 ~ 37%) leave standstill clarification.
9. the arbitrary described dredging collateral of claim 1 ~ 7 protects kidney wine for the preparation of the application in the medicine for the treatment of of insomnia patients.
10. the arbitrary described dredging collateral of claim 1 ~ 7 protects kidney wine for the preparation of the application of dispelling in the medicine of pain.
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| CN201310289374.5 | 2013-07-11 | ||
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| CN201410323560.0A CN104274602B (en) | 2013-07-11 | 2014-07-08 | Dredging collateral protects kidney wine and its preparation technology |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528877A (en) * | 2003-10-17 | 2004-09-15 | 广西半宙制药股份有限公司 | Meridians-activating and kidney-nourishing wine |
| CN101912518A (en) * | 2010-08-11 | 2010-12-15 | 杨莉 | Kidney-tonifying and yang-strengthening capsule |
| CN102008660A (en) * | 2010-12-10 | 2011-04-13 | 徐玉胜 | Formula of kidney-nourishing medicinal liquor |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528877A (en) * | 2003-10-17 | 2004-09-15 | 广西半宙制药股份有限公司 | Meridians-activating and kidney-nourishing wine |
| CN101912518A (en) * | 2010-08-11 | 2010-12-15 | 杨莉 | Kidney-tonifying and yang-strengthening capsule |
| CN102008660A (en) * | 2010-12-10 | 2011-04-13 | 徐玉胜 | Formula of kidney-nourishing medicinal liquor |
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