CN101301422B - Chinese medicinal composition for treating mastitis of milk cattle and preparation and application thereof - Google Patents
Chinese medicinal composition for treating mastitis of milk cattle and preparation and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for curing mastitis of a milk cow. The composition is made of the traditional Chinese raw materials which are purslane, wild chrysanthemum flower, dandelion, borneol, bunge corydalis herb, mongolian snakegourd root, radix paeoniae rubra, senso, garlic, cyrtomium rhizome, indigo and Baikal skullcap root. The invention also relates to a method for making the composition and use of the medicine for curing the mastitis of the milk cow. The product of the invention has evident curing effect on the mastitis of the milk cow, particularly on the intractable mastitis.
Description
Technical field
The present invention relates to decoct the brown transparency liquid that extracts through High Temperature High Pressure from natural Chinese medicinal herb, has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, anti-inflammatory analgetic, be used for the treatment of Chinese medicine composition of all kinds of bovine mastitis diseases and preparation method thereof, also relate to the application of said composition in preparation bovine mastitis medicine.
Background technology
Bovine mastitis is one of common disease of milch cow, and it not only influences the cow in milk milk yield, reduces the economic benefit of cattle, even has influence on the lactogenic function of cattle, finally is forced to eliminate, and also has a strong impact on the quality of breast simultaneously, influences health.According to external, the bovine mastitis sickness rate is 20%～60%, the several big culture zone investigation of China, and this disease sickness rate is 20%～70%, influences the development of China's dairy for many years.The annual direct economic loss that causes dairy by mastitis disease in the whole world is up to more than 300 hundred million dollars, and is single with regard to China, only treats and also will spend nearly hundred million yuans an every year.
The raising of China milch cow at present develops to the industrialization direction, and the intensification degree that the milk source produces improves constantly, and bovine mastitis is the serious hindrance of this industry development always.At present a lot of medication effects are poor, and the high yield cow of oneself is watched because of mastitis disease in a lot of cowboying families, and therapeutic effect is poor, and the performance of giving milk descends or total loss greatly.Bring enormous economic loss to oneself.Greatly dampened the foster milch cow enthusiasm at foster milch cow family, brought serious loss to dairy.
Adopting the means of Chinese medicine to treat the bovine mastitis disease, is a channel extremely leaved for development, and this is because therefore Chinese medicine characteristics such as to have the property of medicine gentle, applied widely are having its original effect aspect the bovine mastitis treatment.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of bovine mastitis, said composition is prepared from by following Chinese medicine raw materials by weight proportion:
Herba Portulacae 3-15 part, Flos Chrysanthemi Indici 2-15 part, Herba Taraxaci 2-15 part, Borneolum Syntheticum 0.1-1 part, Herba Violae 2-15 part, Radix Trichosanthis 2-15 part, Radix Paeoniae Rubra 2-10 part, Venenum Bufonis 0.2-0.5 part, Bulbus Allii 2-15 part, Rhizoma Osmundae 2-8 part, Indigo Naturalis 1-2 part, Radix Scutellariae 2-10 part.
Preferably, said composition is prepared from by following Chinese medicine raw materials by weight proportion:
Herba Portulacae 5-10 part, Flos Chrysanthemi Indici 5-10 part, Herba Taraxaci 5-10 part, Borneolum Syntheticum 0.5-1 part, Herba Violae 5-10 part, Radix Trichosanthis 5-10 part, Radix Paeoniae Rubra 5-8 part, Venenum Bufonis 0.2-0.5 part, Bulbus Allii 5-10 part, Rhizoma Osmundae 4-6 part, Indigo Naturalis 1-2 part, Radix Scutellariae 3-8 part.
Most preferably, said composition is prepared from by following Chinese medicine raw materials by weight proportion:
8 parts of Herba Portulacaes, 8 parts of Flos Chrysanthemi Indicis, 8 parts of Herba Taraxacis, 0.6 part of Borneolum Syntheticum, 8 parts of Herba Violaes, 8 parts of Radix Trichosanthis, 6 parts of Radix Paeoniae Rubras, 0.3 part of Venenum Bufonis, 10 parts in Bulbus Allii, 6 parts of Rhizoma Osmundae, 1.5 parts of Indigo Naturaliss, 6 parts of Radix Scutellariaes.
Chinese medicine composition of the present invention can be made various types of pharmaceutical preparatioies according to actual needs, for example makes oral liquid or injection, and is preferred but be not limited to oral liquid.In order to prepare these preparations, can in compositions of the present invention, add conventional pharmaceutically acceptable auxiliaries as required, selection for adjuvant, those skilled in the art can carry out according to the requirement of dosage form, when for example preparing oral liquid, in the present composition, can add sweeting agent, flavoring agent and antiseptic.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention provides a kind of preparation method of the present composition, it is characterized in that: may further comprise the steps:
1. described Herba Portulacae, Flos Chrysanthemi Indici, Herba Taraxaci, Borneolum Syntheticum, Herba Violae, Radix Trichosanthis, Radix Paeoniae Rubra, Venenum Bufonis, Bulbus Allii, Rhizoma Osmundae, Indigo Naturalis, the dried medicine raw material of Radix Scutellariae 12 flavor Chinese medicines are cleaned, weigh by weight ratio, wash, place and add 5～10 times of amounts of water in the High Temperature High Pressure boiling machine, under 1.5～2.0 pounds of vapour pressures, heat and boiled medicine 40-60 minute, the discharging medicinal liquid, filter by two-layer husky cloth, win time filtrate is standby;
2. for the second time add water 3-5 in the High Temperature High Pressure boiling machine and doubly measure, heat under 1.5-2.0 pound vapour pressure and boiled medicine 20-40 minute, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the second time, and is standby;
3. add water 1-2 for the third time and doubly measure in the High Temperature High Pressure boiling machine, soaked 10-20 minute at normal temperature and pressure, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the third time, and is standby;
4. first time that step 1, step 2, step 3 is standby, for the second time, filtrate places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with the Chinese medicine vaporizer, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6. step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 24-48 hour, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7. step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8. step 7 gained Chinese medicine extraction liquid is regulated pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing promptly gets qualified Chinese medicine composition.
Subsequently, can preparation of compositions of the present invention be become various dosage forms according to the ordinary skill in the art.For example get above standby filtrate, can add flavoring agent and/or antiseptic if desired, regulate pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount, embedding, sterilization, packing promptly gets oral liquid of the present invention.
Described High Temperature High Pressure boiling machine is the High Temperature High Pressure boiling machine of being made by Shandong Province's Qingzhou City absolute sincerity machine-building company limited.
Described Chinese medicine vaporizer is the Chinese medicine vaporizer of being made by device fabrication company limited in the river, Jiangyin City, Jiangsu Province.
Described alcohol recovering device is the alcohol recovering device of being made by Wuxi City, Jiangsu Province Haidah chemical machinery company limited.
Described ethanol is the medical ethanol that meets national standard.
Described water is the tap water that meets national standard for drinking.
Above-mentioned raw material and equipment are all commercially available to be arrived.
Need to prove that method of the present invention is a kind of preferable preparation technique but is not limited to this.Product by the inventive method preparation has good stability.
For many years, adopt Chinese medicine composition of the present invention, particularly the oral liquid treatment bovine mastitis obtains better curative effect, does not see any toxic and side effects.
The present invention be directed to the bovine mastitis disease, particularly the intractable mastitis disease.The source of disease of mastitis disease is that the combination of the composition in the prescription is the various pathogenic bacterium of the pin mastitis characteristics prescriptions extremely responsive to this medicine due to the sense beams such as staphylococcus, streptococcus agalactiae, streptococcus dysgalactiae and other funguses, there is very strong killing action this medicine combination back to mastitis pathogenic bacterium, prescription combination is according to the traditional Chinese medical science, monarch, minister, the formulation principle prescription helping, make, each medicine form the back produce very strong collaborative or shape the antibacterial action of making a concerted effort.Can improve tens of times of curative effects.
The functional component of the Chinese medicine composition of treatment bovine mastitis of the present invention is Herba Portulacae, Flos Chrysanthemi Indici, Herba Taraxaci, Borneolum Syntheticum, Herba Violae, Radix Trichosanthis, Radix Paeoniae Rubra, Venenum Bufonis, Bulbus Allii, Rhizoma Osmundae, Indigo Naturalis, Radix Scutellariae.
In the prescription of treatment bovine mastitis of the present invention: put down in writing according to the Chinese medicine voluminous dictionary:
Herba Portulacae---[function cures mainly]: heat-clearing and toxic substances removing, the blood detumescence of loosing; Control the hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.
Flos Chrysanthemi Indici---[function cures mainly]: wind and heat dispersing, subduing swelling and detoxicating; Control anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters.
Herba Taraxaci---[function cures mainly]: heat-clearing and toxic substances removing, diuresis eliminating stagnation; Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Borneolum Syntheticum---[function cures mainly]: logical all keys, the stagnated fire ， Qu Yi that looses makes eye bright reducing swelling and alleviating pain; Control the apoplexy locked mouth, calentura coma, deafness with qi stagnation, aphtha, otitis media, carbuncle, hemorrhoid, Mu Chi Yi film.
Herba Violae---[function cures mainly]: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling; Control furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.
Radix Trichosanthis---[function cures mainly]: promote the production of body fluid, quench the thirst, pathogenic fire reducing is moisturized, evacuation of pus, detumescence; It is thirsty to control calentura, quenches one's thirst jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.
Radix Paeoniae Rubra---[function cures mainly]: clots absorbing, pain relieving, removing heat from blood, detumescence; Control the stagnant amenorrhea of the stasis of blood, the hernia abdominal mass is gathered, stomachache, costalgia, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.
Venenum Bufonis---[function cures mainly]: detoxifcation, detumescence, heart tonifying, pain relieving; Carbuncle, carbuncle on the back, scrofula, chronic osteomyelitis, laryngopharynx swelling and pain, infantile malnutrition, heart failure, wind, carious pain.
Bulbus Allii---[function cures mainly]: the stagnant gas of row, warming the spleen and stomach, eliminating mass is long-pending, detoxifcation, parasite killing; Control eating accumulation, coldness and pain in the epigastrium, the edema distension is had loose bowels, dysentery, malaria, pertussis, carbuncle infantile malnutrition toxic swelling, white bald tinea skin ulcer, snake bite and insect sting.
Rhizoma Osmundae---[function cures mainly]: kill ascarid, silk ribbon, pinworm, heat clearing away, detoxifcation, removing heat from blood, hemostasis; Control anemopyretic cold, warm skin eruption is spitted blood epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia.
Indigo Naturalis---[function cures mainly]: heat clearing away, removing heat from blood, detoxifcation; Control the epidemic febrile disease intenseness of heat, macule is spitted blood, spitting of blood, and skin ulcer is swollen, erysipelas, snake bite and insect sting.
Radix Scutellariae---[function cures mainly]: the removing the relative excess fire, except that damp and hot, hemostasis, antiabortive; Control the high fever excessive thirst, the cough due to lung-heat, warm dysentery, jaundice, pyretic stranguria is told, collapses, is leaked, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
With the medical material in the above-mentioned prescription by weight ratio complex group fit over together, have following effect:
1, pure Chinese medicinal preparation is pure green medicine, and is pollution-free to milk, and noresidue has no side effect.
2, dosage form is many, and what veterinary's technology arranged can medication, and the people of no veterinary's technology also can medication, and is easy to use.
3, curative effect is outstanding, and effect is remarkable, dosage is little, the medication number of times is few, and cost is low, short treating period, and instant effect, cure rate are absolutely.
4, ill curing the disease, anosis medication can prevent the generation of mastadenitis.
5, this Chinese medicine composition can replace the conventional medicament with antibiotics, chemical antimicrobial drug treatment bovine mastitis disease fully, and it is long to have overcome traditional courses of pharmaceuticals, and weak effect pollutes milk, influences the defective of quality of dairy products.This Chinese medicine composition invention has solved foster milch cow in response to treating mastitis disease with antibiotics, chemical antimicrobial drug, the difficult problem of milk of selling that is caused.
For this reason, another object of the present invention provides the application of a kind of present composition in preparation treatment bovine mastitis medicine.
Description of drawings
Accompanying drawing is preparation technology's flow chart of oral liquid of the Chinese medicine composition of invention.
The specific embodiment
Embodiment 1
Oral liquid:
1. with Herba Portulacae, Flos Chrysanthemi Indici, Herba Taraxaci, Borneolum Syntheticum, Herba Violae, Radix Trichosanthis, Radix Paeoniae Rubra, Venenum Bufonis, Bulbus Allii, Rhizoma Osmundae, Indigo Naturalis, the dried medicine raw material of Radix Scutellariae 12 flavor Chinese medicines cleans, weigh by weight ratio 8 kilograms of Herba Portulacaes, 8 kilograms of Flos Chrysanthemi Indicis, 8 kilograms of Herba Taraxacis, 0.6 kilogram of Borneolum Syntheticum, 8 kilograms of Herba Violaes, 8 kilograms of Radix Trichosanthis, 6 kilograms of Radix Paeoniae Rubras, 0.3 kilogram of Venenum Bufonis, 10 kilograms in Bulbus Allii, 6 kilograms of Rhizoma Osmundae, 1.5 kilograms of Indigo Naturaliss, 6 kilograms of Radix Scutellariaes, washing, place and add 563 kilograms in water (8 times of amounts) in the High Temperature High Pressure boiling machine, under 1.5 pounds of vapour pressures, heat and boiled medicine 50 minutes, the discharging medicinal liquid, filter by two-layer husky cloth, win time filtrate is standby;
2. for the second time add 352 kilograms in water (5 times of amounts) in the High Temperature High Pressure boiling machine, heat under 1.5 pounds of vapour pressures and boiled medicine 30 minutes, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the second time, and is standby;
3. add 140 kilograms in water (2 times of amounts) for the third time in High Temperature High Pressure is boiled medicine filling, soaked 15 minutes at normal temperature and pressure, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the third time, and is standby;
4. first time that step 1, step 2, step 3 is standby, for the second time, filtrate places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with the Chinese medicine vaporizer, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6. step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 30 hours, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7. step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8) step 7 gained Chinese medicine extraction liquid is regulated pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing promptly gets qualified Chinese medicine composition.
Character: this product is brown transparency liquid; Gas perfume (or spice), puckery, little hardship.
Differentiate: get this product 200ml, put in the round-bottomed flask, connect condensing tube (should be short and small) heating and be distilled to about 1 minute of boiling, when treating that crystallization appears in the condensing tube inwall, withdraw thermal source immediately, collect agglomerative crystallization on distillate (about 2-3ml) and the condensing tube inwall.
(1) it is an amount of to take by weighing the crystallization of separating out, and adds ethanol and makes its dissolving, and make the solution that every 1ml contains 2.5mg, as need testing solution.According to ultraviolet-visible spectrophotometer method (appendix VA of Chinese Pharmacopoeia version in 2005) test, be blank with ethanol.Measure absorption curve between wavelength 230-350nm, its absorption curve should be consistent with the absorption curve of Herba Portulacae reference substance solution (1ml contains 2.5ml), at wavelength 289 ± 1nm place one maximum absorption band should be arranged.
(2) getting this product distillate, according to ultraviolet visible spectrophotometry (appendix VA of Chinese Pharmacopoeia version in 2005) test, is blank with water.Wavelength place at wavelength 250-350nm measures absorption curve, at 277 ± 1nm place, a maximum absorption band should be arranged.
Check: relative density should be not less than 0.9 (an appendix VII of Chinese Pharmacopoeia version in 2005 A).
PH value should be 5.5-7.5 (an appendix VII of Chinese Pharmacopoeia version in 2005 G).
Other should meet every regulation relevant under the mixture item (appendix IJ of Chinese Pharmacopoeia version in 2005).
Usage and consumption: oral liquid, a 100-200 milliliter, 2-3 time on the one, or follow the doctor's advice.
Embodiment 2
Injection:
1. with Herba Portulacae, Flos Chrysanthemi Indici, Herba Taraxaci, Borneolum Syntheticum, Herba Violae, Radix Trichosanthis, Radix Paeoniae Rubra, Venenum Bufonis, Bulbus Allii, Rhizoma Osmundae, Indigo Naturalis, the dried medicine raw material of Radix Scutellariae 12 flavor Chinese medicines cleans, weigh by weight ratio 3 kilograms of Herba Portulacaes, 10 kilograms of Flos Chrysanthemi Indicis, 5 kilograms of Herba Taraxacis, 0.1 kilogram of Borneolum Syntheticum, 15 kilograms of Herba Violaes, 6 kilograms of Radix Trichosanthis, 10 kilograms of Radix Paeoniae Rubras, 0.3 kilogram of Venenum Bufonis, 15 kilograms in Bulbus Allii, 2 kilograms of Rhizoma Osmundae, 1 kilogram of Indigo Naturalis, 10 kilograms of Radix Scutellariaes, washing, place and add 697 kilograms in water (9 times of amounts) in the High Temperature High Pressure boiling machine, under 1.5 pounds of vapour pressures, heat and boiled medicine 40 minutes, the discharging medicinal liquid, filter by two-layer husky cloth, win time filtrate is standby;
2. for the second time add 232 kilograms in water (3 times of amounts) in the High Temperature High Pressure boiling machine, heat under 1.5 pounds of vapour pressures and boiled medicine 20 minutes, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the second time, and is standby;
3. add 155 kilograms in water (2 times of amounts) for the third time in High Temperature High Pressure is boiled medicine filling, soaked 20 minutes at normal temperature and pressure, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the third time, and is standby;
4. first time that step 1, step 2, step 3 is standby, for the second time, filtrate places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with the Chinese medicine vaporizer, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6. step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 24 hours, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7. step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8) step 7 gained Chinese medicine extraction liquid is regulated pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing promptly gets qualified Chinese medicine composition.
Embodiment 3
Injection:
1. with Herba Portulacae, Flos Chrysanthemi Indici, Herba Taraxaci, Borneolum Syntheticum, Herba Violae, Radix Trichosanthis, Radix Paeoniae Rubra, Venenum Bufonis, Bulbus Allii, Rhizoma Osmundae, Indigo Naturalis, the dried medicine raw material of Radix Scutellariae 12 flavor Chinese medicines cleans, weigh by weight ratio 15 kilograms of Herba Portulacaes, 15 kilograms of Flos Chrysanthemi Indicis, 10 kilograms of Herba Taraxacis, 1 kilogram of Borneolum Syntheticum, 10 kilograms of Herba Violaes, 12 kilograms of Radix Trichosanthis, 5 kilograms of Radix Paeoniae Rubras, 0.5 kilogram of Venenum Bufonis, 10 kilograms in Bulbus Allii, 8 kilograms of Rhizoma Osmundae, 1 kilogram of Indigo Naturalis, 2 kilograms of Radix Scutellariaes, washing, place and add 537 kilograms in water (6 times of amounts) in the High Temperature High Pressure boiling machine, under 1.5 pounds of vapour pressures, heat and boiled medicine 60 minutes, the discharging medicinal liquid, filter by two-layer husky cloth, win time filtrate is standby;
2. for the second time add 447 kilograms in water (5 times of amounts) in the High Temperature High Pressure boiling machine, heat under 1.5 pounds of vapour pressures and boiled medicine 30 minutes, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the second time, and is standby;
3. add 134 kilograms in water (1.5 times of amounts) for the third time in High Temperature High Pressure is boiled medicine filling, soaked 15 minutes at normal temperature and pressure, the discharging medicinal liquid filters by two-layer husky cloth, gets filtrate for the third time, and is standby;
4. first time that step 1, step 2, step 3 is standby, for the second time, filtrate places container to mix for the third time, precipitation is filtered, filtrate, standby;
5. step 4 gained filtrate is concentrated with the Chinese medicine vaporizer, concentrated concentration is 1/10th of filtrate, gets concentrated solution, and is standby;
6. step 5 gained concentrated solution is added the ethanol of 3 times of amount ethanol contents 95%, room temperature left standstill 36 hours, supernatant porcelain rod sucking filtration, and medicinal residues hang filter with cloth bag, and merging filtrate gets ethanol and mixes filtrate, and is standby;
7. step 6 gained ethanol is mixed filtrate and reclaim ethanol with alcohol recovering device, the filtrate behind the recovery ethanol promptly gets Chinese medicine extraction liquid with filter paper or micro-pore-film filtration, and is standby;
8) step 7 gained Chinese medicine extraction liquid is regulated pH value to 7.0 with sodium hydroxide, and unit of adjustment's total amount is to 1000ml, embedding, sterilization, packing promptly gets qualified Chinese medicine composition.
Injection can be by injection fill a prescription ingredients packing, embedding, sterilization, finished product.
The usage and the consumption of " oral liquid or the injection of treatment bovine mastitis " of various dosage forms
Experimental result shows the using method dosage form, and consumption has substantial connection, and the vein effect is better than intramuscular injection, it is better that consumption is pressed high dose medication effect, and consumption is by middle low dosage medication, and effect is a little low, the effect of the effect of oral liquid and quiet injection, intramuscular injection is hanged down than all, and the course of treatment is longer.From this medicinal medicine approach optimum efficiency of above description of test is intravenous administration, secondly is intramuscular injection, dosage: be by dosage medication better effects if higher in the positive usual amounts.
Best usage and dosage is: the intravenous injection each consumption 40ml of milch cow that grows up, pig 10-20ml medication every day 2 times changed medication every day into 1 time after 3 days.Until recovery from illness.
The oral liquid medication is convenient, does not have veterinary's disposal technology, all can use, and usage is easy, and everybody can both medication, and oral liquid is popular drug formulation.
More than example of the present invention is had been described in detail, but described content only is a preferred embodiments of the present invention, can not be considered to be used to limit practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should belong within the patent covering scope of the present invention.
Claims (3)
1. Chinese medicine composition for the treatment of bovine mastitis, it is characterized in that: said composition is prepared from by following Chinese medicine raw materials by weight proportion:
Herba Portulacae 5-10 part, Flos Chrysanthemi Indici 5-10 part, Herba Taraxaci 5-10 part, Borneolum Syntheticum 0.5-1 part, Herba Violae 5-10 part, Radix Trichosanthis 5-10 part, Radix Paeoniae Rubra 5-8 part, Venenum Bufonis 0.2-0.5 part, Bulbus Allii 5-10 part, Rhizoma Osmundae 4-6 part, Indigo Naturalis 1-2 part, Radix Scutellariae 3-8 part.
2. a kind of Chinese medicine composition for the treatment of bovine mastitis according to claim 1, it is characterized in that: said composition is prepared from by following Chinese medicine raw materials by weight proportion:
8 parts of Herba Portulacaes, 8 parts of Flos Chrysanthemi Indicis, 8 parts of Herba Taraxacis, 0.6 part of Borneolum Syntheticum, 8 parts of Herba Violaes, 8 parts of Radix Trichosanthis, 6 parts of Radix Paeoniae Rubras, 0.3 part of Venenum Bufonis, 10 parts in Bulbus Allii, 6 parts of Rhizoma Osmundae, 1.5 parts of Indigo Naturaliss, 6 parts of Radix Scutellariaes.
3. according to claim 1 or 2 any described a kind of Chinese medicine compositions for the treatment of bovine mastitis, be characterised in that: described compositions is oral liquid or injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101326012A CN101301422B (en) | 2008-07-07 | 2008-07-07 | Chinese medicinal composition for treating mastitis of milk cattle and preparation and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101326012A CN101301422B (en) | 2008-07-07 | 2008-07-07 | Chinese medicinal composition for treating mastitis of milk cattle and preparation and application thereof |
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| Publication Number | Publication Date |
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| CN101301422A CN101301422A (en) | 2008-11-12 |
| CN101301422B true CN101301422B (en) | 2010-10-27 |
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| CN106389920A (en) * | 2016-11-17 | 2017-02-15 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicinal compound preparation for preventing and controlling livestock mastitis, and preparation method thereof |
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2008
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Non-Patent Citations (2)
| Title |
|---|
| 杜自忠.中药治疗牛急性乳腺炎37例.《中兽医学杂志》.1990,(第3期),9. * |
| 马保臣.奶牛乳腺炎的研究.《中国优秀硕士学文论文全文数据库 农业科技辑》.2003,(第3期),37-43. * |
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