CN112641855B - A Chinese medicinal composition for treating or preventing common cold, and its preparation method - Google Patents
A Chinese medicinal composition for treating or preventing common cold, and its preparation method Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating or preventing cold and a preparation method thereof, wherein folium isatidis, desmodium triquetrum, sarcandra glabra and wild chrysanthemum are compatible in the formula for clearing away heat and toxic materials; the combination of holly root, screwtree root, radix achyranthis bidentatae and the like has the effects of relieving exterior syndrome with pungent and cool natured drugs, dispelling wind and heat, detoxifying and relieving sore throat, clearing and benefiting head and eyes, cooling blood by indigowoad leaf, and promoting diuresis, eliminating stagnation and reducing swelling by cucurbit; herba Pileae Scriptae has effects of clearing away heat and toxic materials, dispelling pathogenic wind, and promoting blood circulation; flos Chrysanthemi Indici has effects of purging pathogenic fire and calming liver; flos Ilicis Asprellae has effects of promoting fluid production and promoting blood circulation; the radix achyranthis bidentatae in Guangdong has the functions of dissipating blood stasis and easing joint movement, so that the whole formula has the effects of relieving exterior syndrome with pungent and cool natured drugs, clearing away heat and toxic materials, and reducing phlegm and relieving asthma. Meanwhile, the preparation process is simple, after the treatment of decoction, filtration, extraction, concentration and the like, the raw material components are effectively cooperated, the prepared traditional Chinese medicine composition not only keeps the characteristics of strong effect and quick response of the traditional decoction, but also avoids the loss of effective components caused by long-time decoction, does not contain western medicine components, is safe and has no toxic or side effect, has obvious effect of preventing and treating cold, and has wide application prospect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating or preventing cold and a preparation method thereof.
Background
Cold is a very common and very harmful disease. The common cold is classified into common cold and influenza. Common cold can be classified into wind-cold type, wind-heat type and damp-heat type. The symptoms of wind-cold type common cold are light fever, no sweat, headache, body pain, nasal obstruction, rhinorrhea, cough, white phlegm, thirst and white tongue fur; wind-heat type common cold is manifested by sweating, dry mouth and nose, sore throat, cough, sticky sputum, yellow nasal discharge, and yellow or yellowish tongue fur; the damp-heat cold is caused by the BD virus spreading to the gastrointestinal tract and is often accompanied by symptoms such as abdominal pain, diarrhea, fever and the like; influenza is an acute respiratory infectious disease caused by influenza virus, which exists in the respiratory tract of a patient and is transmitted to other people through droplets when the patient coughs and sneezes, and is manifested by high fever, aversion to cold, headache, dizziness, soreness and pain of limbs, sore throat, thin and yellow tongue coating and the like. At present, common western medicines are clinically used for symptomatic treatment of cold, but the treatment effect is limited, the influence on a human body is large after long-term administration, drug resistance is easy to generate, the side effect is large, and the cost is high.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating or preventing cold and a preparation method thereof, which are used for solving one or more technical problems in the prior art and providing at least one beneficial choice or creation condition.
In order to overcome the technical problems, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition comprises the following raw material components: folium Isatidis, herba Desmodii Triquetri, herba Pileae Scriptae, flos Chrysanthemi Indici, flos Ilicis Asprellae, fructus Rhododendri mollis, and radix Achyranthis bidentatae.
As a further improvement of the scheme, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 350 parts of folium isatidis, 500 parts of common gourd tea, 500 parts of sarcandra glabra, 350 parts of wild chrysanthemum flower, 500 parts of holly leaf, 200 parts of screwtree root and 500 parts of achyranthes aspera.
As a further improvement of the scheme, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 320 parts of dyers woad leaf, 470 parts of hyacinth tea 430, 470 parts of sarcandra glabra 430, 320 parts of wild chrysanthemum flower, 470 parts of roughhaired holly fruit 430, 170 parts of screwtree root 130 and 470 parts of achyranthes aspera 430; preferably 300 parts of folium isatidis, 450 parts of desmodium triquetrum, 450 parts of sarcandra glabra, 300 parts of wild chrysanthemum, 450 parts of holly, 150 parts of screwtree root and 450 parts of achyranthes aspera.
As a further improvement of the scheme, the traditional Chinese medicine composition also comprises sucrose, and the adding amount of the sucrose is 100-200 parts by weight, preferably 150 parts by weight.
As a further improvement of the scheme, the dosage form of the traditional Chinese medicine composition is any one of tablets, granules, capsules, pills, oral liquid or syrup.
The preparation method of the traditional Chinese medicine composition comprises the following steps: mixing folium Isatidis, herba Desmodii Triquetri, herba Pileae Scriptae, flos Chrysanthemi Indici, flos Ilicis Asprellae, fructus Rhododendri mollis and radix Achyranthis bidentatae, adding solvent, decocting, and filtering to obtain filtrate; adding sucrose into the filtrate, stirring, adding alcohol after the sucrose is melted, standing, filtering, collecting supernatant, recovering alcohol, concentrating to obtain paste, granulating, drying, grading, and mixing to obtain the granular Chinese medicinal composition.
As a further improvement of the above, the solvent is water; the addition amount of the solvent is 3 to 8 times, preferably 5 times of the total amount of the raw material components.
As a further improvement of the above scheme, the number of times of decoction is 2-4 times, preferably 3 times; the decoction time is 1-2h, preferably 1.5 h.
As a further improvement of the scheme, the standing time is 8-12h, and preferably 10 h.
The Chinese medicinal composition is applied to preparing medicaments for treating or preventing cold, and comprises the application of preventing and treating cold symptoms caused by upper respiratory tract infection, acute and chronic pharyngitis, tonsillitis, bronchitis and the like.
The raw material components used in the invention have the following properties and effects:
folium isatidis, nature and taste: bitter taste and cold nature. Meridian tropism: it enters heart, lung and stomach meridians. The efficacy is as follows: clear heat and remove toxicity, cool blood and remove macula. Can be used for treating epidemic febrile disease, hyperpyrexia, coma, speckle, eruption, mumps, pharyngitis, erysipelas, and carbuncle.
Calabash tea, nature and taste: bitter and astringent taste, cold and slightly cold nature. Meridian tropism: it enters stomach, kidney and small intestine meridians. The efficacy is as follows: has the effects of clearing away heat, promoting diuresis, eliminating stagnation, killing parasite, and inducing diuresis for removing edema; can be used for treating common cold, pharyngalgia, enteritis, dysentery, jaundice, rheumatic arthralgia, ancylostomiasis, vomiting of pregnancy, infantile malnutrition, sore, and scabies.
Sarcandra glabra, nature and taste: pungent flavor and mild property. Clearing away heat and toxic material, dispelling pathogenic wind, promoting blood circulation, relieving swelling and pain, and resisting bacteria and inflammation. Can be used for treating influenza, Japanese encephalitis, pneumonia, appendicitis, pelvic inflammatory disease, traumatic injury, rheumatic arthralgia, amenorrhea, wound infection, and bacillary dysentery.
Wild chrysanthemum, nature and taste: bitter and slightly pungent in flavor and slightly cold in nature. Meridian tropism: it enters liver and lung meridians. Clear heat and remove toxicity, purge fire and pacify liver. Can be used for treating furuncle, carbuncle, swelling, conjunctival congestion, swelling and pain, headache, and vertigo.
The roughhaired holly root, radix Ilicis Asprellae, with bitter, sweet and cold nature. Has the effects of clearing away heat, promoting salivation, promoting blood circulation, and removing toxic materials. Can be used for treating common cold, headache, vertigo, fever with dryness, acute respiratory syndrome, pyretic diarrhea, pulmonary abscess, and hemoptysis. Laryngalgia, hemorrhoidal bleeding, gonorrhea, carbuncle, and traumatic injury.
Wild sesame, nature and taste: bitter taste and cool nature. Meridian tropism: it enters stomach meridian. Relieve cough, relieve exterior syndrome, clear heat, relieve swelling and remove toxicity. Can be used for treating headache, thirst, measles, dysentery, enteritis, carbuncle, lymphoid tuberculosis, skin sore, eczema, hemorrhoid, common cold, and fever.
Guangdong Tu niu xi is slightly bitter in nature and cool. Has the effects of promoting blood circulation, removing blood stasis, promoting joint movement, clearing away heat and toxic materials, relieving swelling, and promoting urination. Can be used for treating amenorrhea, dysmenorrhea, chronic rheumatic arthritis, lumbar muscle strain, sore throat, rheumatic heart disease, edema, urinary system infection, stomach fire toothache, and venomous snake bite.
The cane sugar is from the sugarcane, and the sugarcane is sweet in nature and taste and cold in nature. Has the effects of clearing heat, promoting the production of body fluid, moistening dryness and descending qi. It can be used for treating fever, body fluid consumption, vexation, thirst, regurgitation, emesis, cough due to lung dryness, and constipation.
The invention has the beneficial effects that:
the invention provides a traditional Chinese medicine composition for treating or preventing cold and a preparation method thereof, the raw material components are reasonably compatible and effectively cooperated, and folium isatidis, desmodium triquetrum, sarcandra glabra and wild chrysanthemum are compatible for clearing away heat and toxic materials; the combination of holly root, screwtree root, radix achyranthis bidentatae and the like has the effects of relieving exterior syndrome with pungent and cool natured drugs, dispelling wind and heat, detoxifying and relieving sore throat, clearing and benefiting head and eyes, cooling blood by indigowoad leaf, and promoting diuresis, eliminating stagnation and reducing swelling by cucurbit; herba Pileae Scriptae has effects of clearing away heat and toxic materials, dispelling pathogenic wind, and promoting blood circulation; flos Chrysanthemi Indici has effects of purging pathogenic fire and calming liver; flos Ilicis Asprellae has effects of promoting fluid production and promoting blood circulation; the radix achyranthis bidentatae in Guangdong has the functions of dissipating blood stasis and easing joint movement, so that the whole formula has the effects of relieving exterior syndrome with pungent and cool natured drugs, clearing away heat and toxic materials, and reducing phlegm and relieving asthma. Meanwhile, the preparation process of the traditional Chinese medicine composition is simple, after the treatment of decoction, filtration, extraction, concentration and the like, the raw material components can be effectively cooperated, the prepared traditional Chinese medicine composition not only keeps the characteristics of strong effect and quick response of the traditional decoction, but also avoids the loss of effective components caused by long-time decoction, can enhance the immune system of a human body and effectively treat or prevent cold symptoms, and the obtained traditional Chinese medicine composition does not contain western medicine components, is safe in medicine, has no toxic or side effect, has obvious prevention and treatment effects, is an effective traditional Chinese medicine composition capable of treating or preventing cold, has wide application prospect and is suitable for wide popularization.
Detailed Description
The present invention is specifically described below with reference to examples in order to facilitate understanding of the present invention by those skilled in the art. It should be particularly noted that the examples are given solely for the purpose of illustration and are not to be construed as limitations on the scope of the invention, as non-essential improvements and modifications to the invention may occur to those skilled in the art, which fall within the scope of the invention as defined by the appended claims. Meanwhile, the raw materials mentioned below are not specified in detail and are all commercially available products; the process steps or extraction methods not mentioned in detail are all process steps or extraction methods known to the person skilled in the art.
Example 1
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 280 parts of dyers woad leaf, 430 parts of desmodium triquetrum, 430 parts of sarcandra, 280 parts of wild chrysanthemum flower, 430 parts of roughhaired holly root, 130 parts of screwtree root, 430 parts of achyranthes aspera and 130 parts of cane sugar.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing 280 parts of folium isatidis, 430 parts of desmodium triquetrum, 430 parts of sarcandra glabra, 280 parts of wild chrysanthemum, 430 parts of roughhaired holly root, 130 parts of screwtree root and 430 parts of eupatorium kwangsiense, selecting, cleaning, cutting into sections with the length of 1-2 cm, putting into a multifunctional extraction tank, adding 5 times of water, and decocting for three times, wherein each time is 1.5 hours; filtering to obtain filtrate, and mixing the three filtrates; adding sucrose into the combined filtrate, stirring, adding ethanol after the sucrose is melted, standing for 10h, filtering, collecting supernatant, recovering ethanol, concentrating to obtain paste, placing the auxiliary materials into a trough mixer, premixing for 5min, adding the extract, and mixing to obtain soft material; and then granulating, drying, finishing and totally mixing to obtain a granular finished product 1 of the traditional Chinese medicine composition for treating or preventing cold.
Example 2
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 320 parts of dyers woad leaf, 470 parts of desmodium triquetrum, 470 parts of sarcandra glabra, 320 parts of wild chrysanthemum, 470 parts of roughhaired holly leaf, 170 parts of screwtree root, 470 parts of radix achyranthis bidentatae and 170 parts of cane sugar.
The preparation method of the traditional Chinese medicine composition comprises the following steps: taking 320 parts of folium isatidis, 470 parts of desmodium triquetrum, 470 parts of sarcandra glabra, 320 parts of wild chrysanthemum, 470 parts of roughhaired holly, 170 parts of screwtree root, 470 parts of eupatorium fortunei and 170 parts of cane sugar by weight, selecting, cleaning, cutting into sections with the length of 1-2 cm, putting into a multifunctional extraction tank, adding 5 times of water for decocting for three times, and decocting for 1.5 hours each time; filtering to obtain filtrate, and mixing the three filtrates; adding sucrose into the combined filtrate, stirring, adding ethanol after the sucrose is melted, standing for 10h, filtering, collecting supernatant, recovering ethanol, concentrating to obtain paste, placing the auxiliary materials into a trough mixer, premixing for 5min, adding the extract, and mixing to obtain soft material; and then granulating, drying, finishing and totally mixing to obtain a granular finished product 2 of the traditional Chinese medicine composition for treating or preventing cold.
Example 3
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 300 parts of folium isatidis, 450 parts of desmodium triquetrum, 450 parts of sarcandra glabra, 300 parts of wild chrysanthemum, 450 parts of holly, 150 parts of screwtree root, 450 parts of radix achyranthis bidentatae and 150 parts of sucrose.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing 300 parts of folium isatidis, 450 parts of desmodium triquetrum, 450 parts of sarcandra glabra, 300 parts of wild chrysanthemum, 450 parts of roughhaired holly root, 150 parts of screwtree root, 450 parts of radix achyranthis bidentatae and 150 parts of cane sugar according to parts by weight, selecting, cleaning, cutting into sections with the length of 1-2 cm, putting into a multifunctional extraction tank, adding 5 times of water for decocting for three times, and decocting for 1.5 hours each time; filtering to obtain filtrate, and mixing the three filtrates; adding sucrose into the combined filtrate, stirring, adding ethanol after the sucrose is melted, standing for 10h, filtering, collecting supernatant, recovering ethanol, concentrating to obtain paste, placing the auxiliary materials into a trough mixer, premixing for 5min, adding the extract, and mixing to obtain soft material; and then granulating, drying, finishing and totally mixing to obtain a granular finished product 3 of the traditional Chinese medicine composition for treating or preventing cold.
Comparative example 1 (without wild chrysanthemum flower and Guangdong achyranthes aspera)
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 300 parts of folium isatidis, 450 parts of desmodium triquetrum, 450 parts of sarcandra glabra, 450 parts of roughhaired holly root, 150 parts of screwtree root and 150 parts of cane sugar.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing 300 parts of folium isatidis, 450 parts of desmodium triquetrum, 450 parts of sarcandra glabra, 450 parts of roughhaired holly, 150 parts of screwtree root and 150 parts of cane sugar according to parts by weight, selecting, cleaning, cutting into sections with the length of 1-2 cm, putting into a multifunctional extraction tank, adding 5 times of water, and decocting for three times, wherein each time of decoction is 1.5 hours; filtering to obtain filtrate, and mixing the three filtrates; adding sucrose into the combined filtrate, stirring, adding ethanol after the sucrose is melted, standing for 10h, filtering, collecting supernatant, recovering ethanol, concentrating to obtain paste, placing the auxiliary materials into a trough mixer, premixing for 5min, adding the extract, and mixing to obtain soft material; and then granulating, drying, finishing and totally mixing to obtain a granular finished product 1 of the traditional Chinese medicine composition comparative example for treating or preventing cold.
Clinical trial
300 cold patients were randomly selected, male and female are not limited, and the main symptoms are as follows: common cold caused by upper respiratory infection, acute and chronic pharyngitis, tonsillitis, bronchitis, etc. All clinical data, diagnosis and typing of cases meet the traditional Chinese medicine syndrome diagnosis standard issued by the State administration of medical government, have no obvious difference (P is more than 0.05), and have comparability. The 300 patients are randomly divided into 4 groups, 75 patients are taken in each group, the first group takes the finished traditional Chinese medicine composition product 1 for treating or preventing cold of the embodiment 1, the second group takes the finished traditional Chinese medicine composition product 2 for treating or preventing cold of the embodiment 2, the third group takes the finished traditional Chinese medicine composition product 3 for treating or preventing cold of the embodiment 3, the medicine is taken for 2 times a day, one bag (10g) is used for each time, the finished product is soaked in boiling water for 3-5 min when the medicine is taken, the medicine can be taken after slight stirring, the fourth group takes the finished traditional Chinese medicine composition comparative example product 1 for treating or preventing cold, 5-7 days are a treatment course, the number of effective, effective and ineffective patients is counted after 7 days, the total effective rate (%) is calculated, and clinical symptoms are observed at the same time.
The curative effect standard is as follows: firstly, healing: the cold patients are completely recovered without cold symptoms; secondly, effect is displayed: the patient gradually improves, the symptoms are obviously relieved, and the effect is obviously improved; ③ effective: the symptoms are relieved and the effect is improved to a certain extent; fourthly, invalidation: no improvement or no significant effect. The results are shown in table 1 below:
TABLE 1 test results of the final products of examples 1-3 and comparative example 1, respectively, on cold sufferers
Clinical tests and as can be seen from table 1, the number of healing people and the total effective rate of the first three groups taking the finished traditional Chinese medicine composition for treating or preventing cold are obviously higher than those of the fourth group, namely, the effects and performances of the finished traditional Chinese medicine composition obtained in examples 1-3 are obviously better than those of the fourth group. Therefore, the components in the formula of the traditional Chinese medicine composition are reasonably compatible and effectively cooperated, the prepared traditional Chinese medicine composition not only keeps the characteristics of strong effect and quick response of the traditional decoction, but also avoids the loss of effective components caused by long-time decoction, can strengthen the immune system of a human body and effectively treat or prevent cold symptoms, and the traditional Chinese medicine composition does not contain western medicine components, has safe medicine, no toxic or side effect and obvious prevention and treatment effects, is an effective traditional Chinese medicine composition for treating or preventing cold, has wide application prospect and is suitable for wide popularization.
It will be obvious to those skilled in the art that many simple derivations or substitutions can be made without inventive effort without departing from the inventive concept. Therefore, simple modifications to the present invention by those skilled in the art according to the present disclosure should be within the scope of the present invention. The above embodiments are preferred embodiments of the present invention, and all similar processes and equivalent variations to those of the present invention should fall within the scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating cold is characterized by comprising the following raw materials in parts by weight: 350 parts of folium isatidis, 500 parts of common gourd tea, 500 parts of sarcandra glabra, 350 parts of wild chrysanthemum flower, 500 parts of holly leaf, 200 parts of screwtree root and 500 parts of achyranthes aspera.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 320 portions of dyers woad leaf, 430 portions of calabash tea, 470 portions of glabrous sarcandra herb, 430 portions of glabrous sarcandra herb, 320 portions of wild chrysanthemum flower, 470 portions of roughhaired holly leaf, 130 portions of screwtree root, 170 portions of screwtree root and 470 portions of achyranthes aspera flower.
3. The traditional Chinese medicine composition according to claim 2, which is characterized by comprising the following raw material components in parts by weight: 300 parts of folium isatidis, 450 parts of desmodium triquetrum, 450 parts of sarcandra glabra, 300 parts of wild chrysanthemum, 450 parts of holly, 150 parts of screwtree root and 450 parts of radix achyranthis bidentatae.
4. The Chinese medicinal composition as claimed in claim 1, further comprising sucrose in an amount of 100-200 parts by weight.
5. The traditional Chinese medicine composition as claimed in claim 1, wherein the dosage form of the traditional Chinese medicine composition is any one of tablets, granules, capsules, pills, oral liquid or syrup.
6. The method for preparing the traditional Chinese medicine composition of any one of claims 1 to 5, which is characterized by comprising the following steps: mixing folium Isatidis, herba Desmodii Triquetri, herba Pileae Scriptae, flos Chrysanthemi Indici, flos Ilicis Asprellae, fructus Rhododendri mollis and radix Achyranthis bidentatae, adding solvent, decocting, and filtering to obtain filtrate; adding sucrose into the filtrate, stirring, adding alcohol after the sucrose is melted, standing, filtering, collecting supernatant, recovering alcohol, concentrating to obtain paste, granulating, drying, grading, and mixing to obtain the granular Chinese medicinal composition.
7. The method according to claim 6, wherein the solvent is water; the addition amount of the solvent is 3-8 times of the total amount of the raw material components.
8. The method according to claim 6, wherein the number of the decoction is 2 to 4; the decoction time is 1-2 h.
9. The method of claim 6, wherein the standing time is 8 to 12 hours.
10. Use of a Chinese medicinal composition according to any one of claims 1 to 5 in the manufacture of a medicament for the treatment of cold.
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