CN101912442A - Micro-enema for treating upper respiratory track infection and preparation method thereof - Google Patents
Micro-enema for treating upper respiratory track infection and preparation method thereof Download PDFInfo
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- CN101912442A CN101912442A CN 201010241915 CN201010241915A CN101912442A CN 101912442 A CN101912442 A CN 101912442A CN 201010241915 CN201010241915 CN 201010241915 CN 201010241915 A CN201010241915 A CN 201010241915A CN 101912442 A CN101912442 A CN 101912442A
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Abstract
The invention discloses a micro-enema for treating upper respiratory track infection and a preparation method thereof. The micro-enema is prepared from the following raw materials by weight: 10 to 200g of lonicera confusa, 10 to 200g of scutellaria baicalensis, and 10 to 200g of bupleurum. The preparation method comprises the following steps of: decocting and extracting the scutellaria baicalensis, adjusting the pH value of the decocted mixture by using sodium hydroxide solution in each decocting process, mixing the obtained decoction liquid so as to obtain liquid A; adding water into the bupleurum for distillation, collecting distillate produced in the first 30 to 40 minutes so as to obtain liquid B; adding water into the produced dregs of a decoction of the bupleurum and the lonicera confusa for decoction, mixing the obtained two-time decoction liquid and the residual liquid of the bupleurum subjected to distillation, concentrating and filtering the obtained liquid, and adjusting the PH value of the obtained filter liquid so as to obtain liquid C; and finally, mixing 30 to 35 volume percent of liquid A, 5 to 10 volume percent of liquid B and 55 to 60 volume percent of liquid C, and then carrying out separated-loading and sterilization on the obtained liquid so as to obtain the micro-enema. The micro-enema product produced by the method of the invention has the advantages of quick response to and good curative effect on infantile hyperpyretic symptoms and convenient use.
Description
Technical field
The present invention relates to a kind of enema, be specifically related to a kind of micro-enema for the treatment of upper respiratory tract infection and preparation method thereof.
Background technology
The Chinese traditional treatment emergency case is one of modern difficult point of the traditional Chinese medical science, owing to be subjected to the restriction of form of Chinese drug, to be considered to be speciality with the treatment of chronic diseases only to the traditional Chinese medical science for a long time, is difficult to show the advantage for the treatment of emergency case.In order to solve this difficult problem, Chinese medicine has been studied decades, because Chinese medicine mostly is compound preparation, complicated component, and the strictness of injection prescription, volume is little, the clarity height, and Chinese medicine is in the preparation technology who removes crudely and store essence, often be difficult to keep stable curative effect, add that medicinal raw material difference is big, quality is wayward, and problems such as anaphylaxis, zest are often arranged.Therefore, Chinese medicine can not enter Chinese Pharmacopoeia always, and the kind of Shi Yonging is also few clinically.The Chinese medicine micro-enema can solve the difficult problem of Chinese medicine, the same liquid medicine that is both of Chinese medicine micro-enema with Chinese medicine, volume is also only below 5ml, but the Chinese medicine micro-enema does not require clarity, can be made into high concentration, full-bodied solution, the ingredient that comprises is many, can keep stable curative effect.Because the administration of Chinese medicine micro-enema per anum, the medicine per rectum directly enters the blood of human body systemic circulation after absorbing, and can avoid effective ingredient to be subjected to the destruction of gastric acid, enteral digestion liquid, also avoids the first-pass effect of liver, thereby keeps drug effect.
Infantile hyperpyrexia (fever) is one of modal symptom that causes owing to upper respiratory tract infection, because children's's health is in growth and development stage, its nervous system development is still incomplete.Because central nervous system's regulatory function of children's is poor, sweat gland of skin is grown and is gone back imperfection, and the thermoregulation function is very poor, and children's is very easy to heating.The hyperpyrexia (more than 39 ℃) that generates heat particularly continued of a specified duration, threatened very big to child health.Statistics shows that the infantile hyperpyrexia sickness rate is 3%～8%, and the relapse rate height is about 35%, and the recurrence frequency is high more, causes that the probability of brain injury is big more, and the serious harm children's's is healthy.The class infantile hyperpyrexia medication of existing Chinese and Western is a lot, the Chinese patent medicine of medication as usual has children's's granule etc. that induces sweat, Western medicine is representative with children's's acetaminophen then, but no matter be that Chinese patent medicine or Western medicine all come with some shortcomings, because Chinese patent medicine is bitter, the fitness that children's does not take medicine is not high, and the side effect of Western medicine is bigger, this makes that also the children's head of a family has a misgiving in medication, the herbal enema agent has then solved the problem that children's is unwilling to take medicine and the Western medicine side effect is big preferably.
Summary of the invention
It is simple that the technical problem to be solved in the present invention provides a kind of raw material, and dosage is little, concentration is high, the micro-enema of easy absorption, rapid-action, good effect, treatment upper respiratory tract infection easy to use and preparation method thereof.
For solving the problems of the technologies described above, the present invention by the following technical solutions:
A kind of micro-enema for the treatment of upper respiratory tract infection, it is to be made by following raw materials by weight proportions:
Flos Lonicerae 10～200, Radix Scutellariae 10～200, Radix Bupleuri 10～200.
The preferred weight proportion of above-mentioned each crude drug is:
Flos Lonicerae 100～200, Radix Scutellariae 40～100, Radix Bupleuri 50～150.
The weight proportion of each crude drug the best is:
Flos Lonicerae 180, Radix Scutellariae 50, Radix Bupleuri 120.
In the above-mentioned prescription, Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication; The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating; Radix Bupleuri is delivered and is brought down a fever.The three share the effect that can strengthen the clearing away heat-fire detoxifcation.Modern study shows that Radix Scutellariae, Flos Lonicerae have fine antibacterial and anti-inflammation functions, and expansion bacterium scope is wide, also has obvious antipyretic effect.Radix Bupleuri also has strong inhibitory action to influenza virus except having stronger antipyretic effect.
The preparation method of the micro-enema of treatment upper respiratory tract infection provided by the invention, step is as follows:
1) getting Radix Scutellariae pulverizes, decoct with water 1～3 time, merge decoction liquor, hydrochloric acid adjust pH to 1.5～2.5, in 75～85 ℃ of insulation 30～40min, cooling, standing over night is filtered, precipitation is washed till near neutral with 60～70% ethanol, with the sodium hydroxide solution dissolving, the hydrochloric acid adjust pH is 5.5～6.0, gets A liquid then; Wherein, decoct after carrying out 10～15min at every turn, transfer pH value to 6.0～7.0 that decoct mixture with sodium hydroxide solution earlier, continue to decoct 1～2h again;
2) get Radix Bupleuri and pulverize, add the water distillation, collect the distillate of front 30～40min, get B liquid, residual liquid and the Radix Bupleuri medicinal residues after the collection distillation are standby respectively;
3) get Radix Bupleuri medicinal residues and Flos Lonicerae and decoct with water 1～2h, filter, filtering residue decocts with water 0.5～1.5h again, filter, merge the residual liquid after secondary decoction liquor and Radix Bupleuri distill, get mixed liquor, concentrate, cooling adds ethanol and makes it contain the alcohol amount to 60～70%, standing over night, filter, be concentrated into 0.3～0.4 times of Radix Bupleuri crude drug weight behind the filtrate recycling ethanol, regulating pH value is 5.5～6.0, C liquid;
4) A liquid, B liquid and C liquid are mixed by 30～35%: 5～10%: 55～60% percent by volume, the percent by volume sum of above-mentioned three kinds of liquid is 100%, stir after the mixing, and packing, sterilization, promptly.
In the above-mentioned preparation method:
In the step 1), the mass concentration of sodium hydroxide solution is 10～15%.And the consumption that is used for the sodium hydroxide solution of dissolution precipitation is 0.3～0.4 times of Radix Scutellariae crude drug weight.Except sodium hydroxide solution, also available sodium carbonate or sodium bicarbonate solution replace, and its concentration is constant.
In the step 1), the addition of water is 6～12 times of Radix Scutellariae crude drug weight when decocting at every turn.The granularity that Radix Scutellariae is pulverized can be 10～100 orders.
Step 2) in, the addition of water is 7～10 times of Radix Bupleuri crude drug weight during distillation.The granularity that Radix Bupleuri is pulverized can be 10～100 orders.
In the step 3), the addition of water is Radix Bupleuri and Flos Lonicerae crude drug gross weight 6～12 times when decocting at every turn.Mixed liquor is concentrated into Radix Bupleuri and Flos Lonicerae crude drug gross weight 0.9～1.1 times.
The effective ingredient that the micro-enema that is made by said method is every milliliter is equivalent to 4.48 gram crude drug raw materials, generally is distributed into 4ml/ and props up.
Compared with prior art, micro-enema raw material of the present invention is formed simple, method is simple and easy to control, the special pH value that adds sodium hydroxide adjusting decoction liquor (acidity of decoction liquor is stronger) when extracting Radix Scutellariae, to prevent that effective ingredient baicalin in the Radix Scutellariae from being cleared up into glycoside unit and sugared under sour environment, well kept the effective ingredient in the Radix Scutellariae; Products obtained therefrom dosage is little, concentration is high, easy absorption,, good effect rapid-action to the infantile hyperpyrexia symptom, and also easy to use.
The specific embodiment
Embodiment 1
Crude drug prescription: Flos Lonicerae 500g Radix Scutellariae 1000g Radix Bupleuri 1000g
Preparation method:
1) getting Radix Scutellariae powder and be broken to 10 orders, add the water of 12 times of Radix Scutellariae raw material weights, decoct 10min (picking up counting) after water is opened, is that 10% sodium hydroxide solution is transferred the pH value to 6.5 that decocts mixture with mass concentration, continues decoction 1.5h again; Filter, filtering residue adds the water of 8 times of Radix Scutellariae raw material weights, decoct 10min (after water is opened, picking up counting), with mass concentration is that 10% sodium hydroxide solution is transferred the pH value to 6.5 that decocts mixture, continue to decoct 1.0h again, filter, merge decoction liquor, transfer its pH value to 2.0 with hydrochloric acid, in 80 ℃ of insulation 30min, cooling, standing over night is filtered, precipitation is that to be washed till pH value be 6.0 to 70% ethanol with volumetric concentration, being the dissolving of 10% sodium hydroxide solution with 0.35 times of Radix Scutellariae raw material weight, mass concentration then, is 5.8 with the hydrochloric acid adjust pH afterwards, must A liquid;
2) get Radix Bupleuri and be crushed to 10 orders, add the distillation of 10 times of water of Radix Bupleuri raw material weight, collect from have distillate begin after the distillate of 30min, B liquid, collect residual liquid and Radix Bupleuri medicinal residues after distilling respectively, standby;
3) get Radix Bupleuri medicinal residues and Flos Lonicerae, (for the first time the addition of water is 10 times of Radix Bupleuri and Flos Lonicerae raw material gross weights to decoct with water 2 times, decoct 1.5h, for the second time the addition of water is 8 times of Radix Bupleuri and Flos Lonicerae raw material gross weights, decoct 1h), filter, merge the residual liquid after secondary decoction liquor and Radix Bupleuri distill, get mixed liquor, mixed liquor is concentrated into 1.0 times that are equivalent to Radix Bupleuri and Flos Lonicerae crude drug gross weight, get once concentration liquid, cooling, add ethanol make once concentration liquid to contain the alcohol amount be 70%, standing over night is filtered, be concentrated into 0.35 times of Radix Bupleuri crude drug weight behind the filtrate recycling ethanol, get secondary concentration liquid, the pH value of regulating secondary concentration liquid with hydrochloric acid or sodium hydroxide solution is 5.8, gets C liquid;
4) A liquid, B liquid and C liquid are mixed by 35%: 5%: 60% percent by volume, stir, be distributed into 4ml/ and prop up, sterilization, promptly.
The effective ingredient that the gained micro-enema is every milliliter is equivalent to 4.48 gram crude drug raw materials.
Embodiment 2
Crude drug prescription: Flos Lonicerae 1000g Radix Scutellariae 1500g Radix Bupleuri 500g
Preparation method:
1) getting Radix Scutellariae powder and be broken to 40 orders, add the water of 10 times of Radix Scutellariae raw material weights, decoct 10min (picking up counting) after water is opened, is that 10% sodium hydroxide solution is transferred the pH value to 7.0 that decocts mixture with mass concentration, continues decoction 1.5h again; Filter, filtering residue adds the water of 8 times of Radix Scutellariae raw material weights, decocts 15min (picking up counting after water is opened), is that 10% sodium hydroxide solution is transferred the pH value to 6.0 that decocts mixture with mass concentration, continues decoction 1.0h again; Filter, filtering residue adds the water of 6 times of Radix Scutellariae raw material weights, decocts 10min (picking up counting after water is opened), is that 10% sodium hydroxide solution is transferred the pH value to 6.5 that decocts mixture with mass concentration, continues decoction 1.0h again; Filter, merge decoction liquor, transfer its pH value to 1.8 with hydrochloric acid, in 75 ℃ of insulation 35min, cooling, standing over night, filter, precipitation with volumetric concentration be 65% ethanol to be washed till pH value be 7.0, be that 15% sodium hydroxide solution dissolves with 0.4 times of Radix Scutellariae raw material weight, mass concentration then, be 6.0 with the hydrochloric acid adjust pH afterwards, get A liquid;
2) get Radix Bupleuri and be crushed to 10 orders, add the distillation of 8 times of water of Radix Bupleuri raw material weight, collect from have distillate begin after the distillate of 40min, B liquid, collect residual liquid and Radix Bupleuri medicinal residues after distilling respectively, standby;
3) get Radix Bupleuri medicinal residues and Flos Lonicerae, (for the first time the addition of water is 12 times of Radix Bupleuri and Flos Lonicerae raw material gross weights to decoct with water 2 times, decoct 2h, for the second time the addition of water is 6 times of Radix Bupleuri and Flos Lonicerae raw material gross weights, decoct 0.5h), filter, merge the residual liquid after secondary decoction liquor and Radix Bupleuri distill, get mixed liquor, mixed liquor is concentrated into 0.9 times that is equivalent to Radix Bupleuri and Flos Lonicerae crude drug gross weight, get once concentration liquid, cooling, add ethanol make once concentration liquid to contain the alcohol amount be 65%, standing over night is filtered, be concentrated into 0.3 times of Radix Bupleuri crude drug weight behind the filtrate recycling ethanol, get secondary concentration liquid, the pH value of regulating secondary concentration liquid with hydrochloric acid or sodium hydroxide solution is 6.0, gets C liquid;
4) A liquid, B liquid and C liquid are mixed by 32%: 8%: 58% percent by volume, stir, be distributed into 4ml/ and prop up, sterilization, promptly.
The effective ingredient that the gained micro-enema is every milliliter is equivalent to 4.48 gram crude drug raw materials.
Embodiment 3
Crude drug prescription: Flos Lonicerae 1500g Radix Scutellariae 1000g Radix Bupleuri 1500g
Preparation method:
1) getting Radix Scutellariae powder and be broken to 80 orders, add the water of 12 times of Radix Scutellariae raw material weights, decoct 10min (picking up counting) after water is opened, is that 10% sodium hydroxide solution is transferred the pH value to 6.0 that decocts mixture with mass concentration, continues decoction 2h again; Filter, decoction liquor, transfer its pH value to 2.5 with hydrochloric acid, in 85 ℃ of insulation 30min, cooling, standing over night, filter, precipitation with volumetric concentration be 65% ethanol to be washed till pH value be 6.5, be that 10% sodium hydroxide solution dissolves with 0.3 times of Radix Scutellariae raw material weight, mass concentration then, be 5.5 with the hydrochloric acid adjust pH afterwards, get A liquid;
2) get Radix Bupleuri and be crushed to 40 orders, add the distillation of 7 times of water of Radix Bupleuri raw material weight, collect from have distillate begin after the distillate of 35min, B liquid, collect residual liquid and Radix Bupleuri medicinal residues after distilling respectively, standby;
3) get Radix Bupleuri medicinal residues and Flos Lonicerae, (for the first time the addition of water is 8 times of Radix Bupleuri and Flos Lonicerae raw material gross weights to decoct with water 2 times, decoct 1.0h, for the second time the addition of water is 8 times of Radix Bupleuri and Flos Lonicerae raw material gross weights, decoct 1.0h), filter, merge the residual liquid after secondary decoction liquor and Radix Bupleuri distill, get mixed liquor, mixed liquor is concentrated into 1.1 times that are equivalent to Radix Bupleuri and Flos Lonicerae crude drug gross weight, get once concentration liquid, cooling, add ethanol make once concentration liquid to contain the alcohol amount be 60%, standing over night is filtered, be concentrated into 0.4 times of Radix Bupleuri crude drug weight behind the filtrate recycling ethanol, get secondary concentration liquid, the pH value of regulating secondary concentration liquid with hydrochloric acid or sodium hydroxide solution is 5.5, gets C liquid;
4) A liquid, B liquid and C liquid are mixed by 30%: 10%: 60% percent by volume, stir, be distributed into 4ml/ and prop up, sterilization, promptly.
The effective ingredient that the gained micro-enema is every milliliter is equivalent to 4.48 gram crude drug raw materials.
Embodiment 4
Crude drug prescription: Flos Lonicerae 1800g Radix Scutellariae 500g Radix Bupleuri 1200g
Preparation method:
1) getting Radix Scutellariae powder and be broken to 100 orders, add the water of 12 times of Radix Scutellariae raw material weights, decoct 10min (picking up counting) after water is opened, is that 10% sodium hydroxide solution is transferred the pH value to 6.0 that decocts mixture with mass concentration, continues decoction 1.5h again; Filter, filtering residue adds the water of 10 times of Radix Scutellariae raw material weights, decoct 15min (after water is opened, picking up counting), with mass concentration is that 10% sodium hydroxide solution is transferred the pH value to 6.0 that decocts mixture, continue to decoct 1.5h again, filter, merge decoction liquor, transfer its pH value to 2.0 with hydrochloric acid, in 80 ℃ of insulation 30min, cooling, standing over night is filtered, precipitation is that to be washed till pH value be 6.5 to 70% ethanol with volumetric concentration, being the dissolving of 10% sodium hydroxide solution with 0.4 times of Radix Scutellariae raw material weight, mass concentration then, is 6.0 with the hydrochloric acid adjust pH afterwards, must A liquid;
2) get Radix Bupleuri and be crushed to 60 orders, add the distillation of 9 times of water of Radix Bupleuri raw material weight, collect from have distillate begin after the distillate of 30min, B liquid, collect residual liquid and Radix Bupleuri medicinal residues after distilling respectively, standby;
3) get Radix Bupleuri medicinal residues and Flos Lonicerae, (for the first time the addition of water is 10 times of Radix Bupleuri and Flos Lonicerae raw material gross weights to decoct with water 2 times, decoct 2h, for the second time the addition of water is 6 times of Radix Bupleuri and Flos Lonicerae raw material gross weights, decoct 1h), filter, merge the residual liquid after secondary decoction liquor and Radix Bupleuri distill, get mixed liquor, mixed liquor is concentrated into 1.0 times that are equivalent to Radix Bupleuri and Flos Lonicerae crude drug gross weight, get once concentration liquid, cooling, add ethanol make once concentration liquid to contain the alcohol amount be 70%, standing over night is filtered, be concentrated into 0.3 times of Radix Bupleuri crude drug weight behind the filtrate recycling ethanol, get secondary concentration liquid, the pH value of regulating secondary concentration liquid with hydrochloric acid or sodium hydroxide solution is 6.0, gets C liquid;
4) A liquid, B liquid and C liquid are mixed by 35%: 10%: 55% percent by volume, stir, be distributed into 4ml/ and prop up, sterilization, promptly.
The effective ingredient that the gained micro-enema is every milliliter is equivalent to 4.48 gram crude drug raw materials.
The applicant once carried out clinical observation research with medicine of the present invention to 17 routine infantile hyperpyrexia patients in second Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, and data are as follows:
Adopt randomized blocks to observe infantile hyperpyrexia patient 17 examples, wherein 6 examples are treated with the micro-enema that the embodiment of the invention 1 makes, and 11 examples compare group with antifebrile suppository for children (Guangzhou Baiyunshan Hejigong Pharmaceutical Co., Ltd).The total effective rate of treatment group as a result is 82.35%, matched group 81.81%.Treatment group acceptance rate is 58.82%, matched group 36.36%, and treatment group effect has the trend that is better than matched group.
Claims (10)
1. micro-enema for the treatment of upper respiratory tract infection is characterized in that it is to be made by following raw materials by weight proportions:
Flos Lonicerae 10～200, Radix Scutellariae 10～200, Radix Bupleuri 10～200.
2. the micro-enema of treatment upper respiratory tract infection according to claim 1 is characterized in that: the weight proportion of each crude drug is:
Flos Lonicerae 100～200, Radix Scutellariae 40～100, Radix Bupleuri 50～150.
3. the micro-enema of treatment upper respiratory tract infection according to claim 2 is characterized in that: the weight proportion of each crude drug is:
Flos Lonicerae 180, Radix Scutellariae 50, Radix Bupleuri 120.
4. the preparation method of the micro-enema of the described treatment upper respiratory tract infection of claim 1 is characterized in that step is as follows:
1) getting Radix Scutellariae pulverizes, decoct with water 1～3 time, merge decoction liquor, hydrochloric acid adjust pH to 1.5～2.5, in 75～85 ℃ of insulation 30～40min, cooling, standing over night is filtered, precipitation is washed till near neutral with 60～70% ethanol, with the sodium hydroxide solution dissolving, the hydrochloric acid adjust pH is 5.5～6.0, gets A liquid then; Wherein, decoct when carrying out 10～15min at every turn, transfer pH value to 6.0～7.0 that decoct mixture with sodium hydroxide solution earlier, continue to decoct 1～2h again;
2) get Radix Bupleuri and pulverize, add the water distillation, collect the distillate of front 30～40min, get B liquid, residual liquid and the Radix Bupleuri medicinal residues after the collection distillation are standby respectively;
3) get Radix Bupleuri medicinal residues and Flos Lonicerae and decoct with water 1～2h, filter, filtering residue decocts with water 0.5～1.5h again, filter, merge the residual liquid after secondary decoction liquor and Radix Bupleuri distill, get mixed liquor, concentrate, cooling adds ethanol and makes it contain the alcohol amount to 60～70%, standing over night, filter, be concentrated into 0.3～0.4 times of Radix Bupleuri crude drug weight behind the filtrate recycling ethanol, regulating pH value is 5.5～6.0, C liquid;
4) A liquid, B liquid and C liquid are mixed by 30～35%: 5～10%: 55～60% percent by volume, the percent by volume sum of above-mentioned three kinds of liquid is 100%, stir after the mixing, and packing, sterilization, promptly.
5. the preparation method of the micro-enema of treatment upper respiratory tract infection according to claim 4 is characterized in that: in the step 1), the mass concentration of sodium hydroxide solution is 10～15%.
6. the preparation method of the micro-enema of treatment upper respiratory tract infection according to claim 5 is characterized in that: in the step 1), the consumption that is used for the sodium hydroxide solution of dissolution precipitation is 0.3～0.4 times of Radix Scutellariae crude drug weight.
7. the preparation method of the micro-enema of treatment upper respiratory tract infection according to claim 4 is characterized in that: in the step 1), the addition of water is 6～12 times of Radix Scutellariae crude drug weight when decocting at every turn.
8. the preparation method of the micro-enema of treatment upper respiratory tract infection according to claim 4 is characterized in that: step 2) in, the addition of water is 7～10 times of Radix Bupleuri crude drug weight during distillation.
9. the preparation method of the micro-enema of treatment upper respiratory tract infection according to claim 4 is characterized in that: in the step 3), the addition of water is Radix Bupleuri and Flos Lonicerae crude drug gross weight 6～12 times when decocting at every turn.
10. the preparation method of the micro-enema of treatment upper respiratory tract infection according to claim 4 is characterized in that: in the step 3), mixed liquor is concentrated into Radix Bupleuri and Flos Lonicerae crude drug gross weight 0.9～1.1 times.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198123A (en) * | 2011-03-31 | 2011-09-28 | 中国人民解放军第三军医大学第一附属医院 | Ibuprofen microenema preparation and preparation method thereof |
| CN103191206A (en) * | 2013-03-16 | 2013-07-10 | 高本安 | Traditional Chinese medicine enema for treating infantile exogenous prolonged high fever |
| CN105535608A (en) * | 2016-01-07 | 2016-05-04 | 安徽为民制药有限公司 | Traditional Chinese medicine for treating infantile upper respiratory infection |
-
2010
- 2010-07-30 CN CN 201010241915 patent/CN101912442A/en active Pending
Non-Patent Citations (2)
| Title |
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| 《中国实验方剂学杂志》 19990430 陈燕军 等 《复方银黄微型灌肠剂中柴胡与金银花提取工艺的优选》 第14、15页 5-10 第5卷, 第2期 2 * |
| 《中国实验方剂学杂志》 20061231 刘华钢 等 《复方银黄微型灌肠剂人体内药代动力学研究》 第10-12页 1-10 第12卷, 第12期 2 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198123A (en) * | 2011-03-31 | 2011-09-28 | 中国人民解放军第三军医大学第一附属医院 | Ibuprofen microenema preparation and preparation method thereof |
| CN102198123B (en) * | 2011-03-31 | 2012-10-31 | 中国人民解放军第三军医大学第一附属医院 | Ibuprofen microenema preparation and preparation method thereof |
| CN103191206A (en) * | 2013-03-16 | 2013-07-10 | 高本安 | Traditional Chinese medicine enema for treating infantile exogenous prolonged high fever |
| CN103191206B (en) * | 2013-03-16 | 2014-08-20 | 高本安 | Traditional Chinese medicine enema for treating infantile exogenous prolonged high fever |
| CN105535608A (en) * | 2016-01-07 | 2016-05-04 | 安徽为民制药有限公司 | Traditional Chinese medicine for treating infantile upper respiratory infection |
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