CN101450133A - Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion - Google Patents
Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion Download PDFInfo
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- CN101450133A CN101450133A CNA2007101971991A CN200710197199A CN101450133A CN 101450133 A CN101450133 A CN 101450133A CN A2007101971991 A CNA2007101971991 A CN A2007101971991A CN 200710197199 A CN200710197199 A CN 200710197199A CN 101450133 A CN101450133 A CN 101450133A
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Abstract
The invention discloses a pharmaceutical composition for preventing belly postoperative adhesion and preparation method thereof. The pharmaceutical composition consists of astragalus or Radix Codonopsis, red sage root, banksia rose, bitter orange, rheum officinale or senna leaf, saltcake, magnolia cortex, Chinese angelica and licorice. The composition is prepared by: decocting by water, collecting the volatile oil; removing the residues; concentrating the extract, adding 95% ethanol to raise the alcohol content to 40-60%; leaving statically for 24 hours; centrifuging, removing deposition, recovering ethanol from supernatant and adding volatile oil. And the medicine can be made into oral liquid, tablet, soluble granules, capsule and injection by adding pharmaceutics acceptable auxiliary materials according to common technology. The composition achieves the effects of supplementing qi, removing blood stasis, promoting qi circulation and clearing hollow viscera, can be used for treating belly postoperative adhesion which belongs to qi-deficiency blood stasis qi stagnation hollow viscera filled disease.
Description
Technical field
The present invention relates to field of medicaments, a kind of in more detail Chinese medicine preparation that is used to prevent and treat tissue adhesion.
Background technology
Tissue adhesion is an operation back common complication, its incidence rate is up to more than 90%, and the clinical onset rate is the main cause of abdominal part chronic pain, infertility etc. also up to 40%, severe patient also can cause adhesive ileus (sickness rate is up to 9.7%), belongs to common clinical and prevents and treats one of difficult point.At present domestic still do not have specially at the medicine of preventing and treating tissue adhesion.At present, the control of tissue adhesion is mainly set about from the following aspects:
1. reduce tissue injury: soft operation, careful hemostasis, the control of lavation fully foreign body is residual etc.Not enough: tissue injury is inevitable.
2. prevent the local organization ischemia: intraperitoneal procaine blood vessel dilating, the FUFANG DANSHEN ZHUSHEYE microcirculation improvement prevents tissue ischemia.Not enough: zest is big, brings the chance of infection.
3. prevent fiber laydown: the application of corticosteroid and nonsteroidal and-inflammatory drug, somatostatin class thing, the gentle kallikrein inhibitor of blood plasma enzyme etc.Not enough: immunosuppressant influences wound healing etc.
4. promotion fibrolysis: cytokines such as recombinant tissue plasminogen activator.Not enough: effective dose influences wound healing, and extractive technique is limited, costs an arm and a leg.
5. serosa surface is isolated: medicine barrier such as full-bodied solution or hydrogel etc.Mechanical barrier such as Fibrin Glue etc.Not enough: the sterile working requires high, easily brings infection, and clinical compliance is not enough.
6. Chinese medicine: antiinflammatory, exudation, edema, and the application of Chinese medicine such as blood circulation promoting and blood stasis dispelling.Not enough: main clinical proved recipe and hospital preparation, do not have the listing product.
Summary of the invention
Purpose of the present invention: provide a kind of super quality and competitive price, effectively the new Chinese medicine of prevention of postoperative adhesion; And the preparation method that the new Chinese medicine of its prevention of postoperative adhesion is provided.
The abdominal post-operation adhesion is a common clinical.The traditional Chinese medical science thinks, the showing as of abdominal post-operation adhesion: abdominal distention, and stomachache, localized pain, weak, weak breath etc. belong to syndrome of deficiency of QI.Because of operation also is easy to consume the body healthy energy of hurting sb.'s feelings in the excision focus, cause the deficiency of vital energy and blood stasis, but and secondary local blood stasis, i.e. blood stasis due to qi deficiency.Therefore, should be based on benefiting qi and removing blood stasis, the circulation of qi promoting purging FU-organs is auxilliary.We find clinically: postoperative patient has deficiency of vital energy person to account for 83%, and the person accounts for 68% the blood stasis, has blood stasis due to qi deficiency person to account for 59%; And think for patient's analysis of abdominal post-operation adhesion: blood stasis due to qi deficiency syndrome person accounts for 88%.Therefore, can think that the pathogenesis characteristics of tissue adhesion are blood stasis due to qi deficiency, treatment should be with benefiting qi and removing blood stasis, and circulation of qi promoting purging FU-organs, reinforcement and elimination in combination are rule of treatment.
According to Chinese medical theory.Select the Radix Astragali, Radix Angelicae Sinensis QI invigorating and blood producing for use; Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, the Cortex Magnoliae Officinalis purging FU-organs of regulating the flow of vital energy; Radix Et Rhizoma Rhei, Natrii Sulfas, Folium Sennae are rushed down blood stasis dispelling down; Radix Salviae Miltiorrhizae, Flos Carthami, pseudo-ginseng blood-circulation-invigovating blood stasis dispelling.The pathogenesis that suits the Postoperative Peritoneal Adhesion blood stasis due to qi deficiency.
The Chinese medicine preparation that is used to prevent and treat tissue adhesion of the present invention is characterized in that being made by the Chinese medicine of following ratio of weight and number: the Radix Astragali 15～25, Radix Salviae Miltiorrhizae 15～25, Radix Et Rhizoma Rhei 5～15, Fructus Aurantii Immaturus 5～15, Radix Angelicae Sinensis 1～5, Cortex Magnoliae Officinalis 1～5.
The Chinese medicine preparation that is used to prevent and treat tissue adhesion of the present invention is characterized in that being made by the Chinese medicine of following ratio of weight and number: Radix Codonopsis 15～25, Radix Salviae Miltiorrhizae 15～25, Folium Sennae 5～15, Fructus Aurantii Immaturus 5～15, Rhizoma Cyperi 1～5, Rhizoma Corydalis 1～5.
The Chinese medicine preparation that is used to prevent and treat tissue adhesion of the present invention is characterized in that being made by the Chinese medicine of following ratio of weight and number: the Radix Astragali 15～25, Flos Carthami 15～25, Natrii Sulfas 5～15, Fructus Aurantii 5～15, Radix Angelicae Sinensis 1～5, the Radix Aucklandiae 1～5.
The Chinese medicine preparation that is used to prevent and treat tissue adhesion of the present invention is characterized in that being made by the Chinese medicine of following ratio of weight and number: the Radix Astragali 15～25, Radix Notoginseng 15～25, Natrii Sulfas 5～15, Fructus Aurantii 5～15, Radix Angelicae Sinensis 1～5, the Radix Aucklandiae 1～5.
More than the Chinese medicine preparation of four kinds of proportionings, it is characterized in that described preparation is tablet (comprising tablets such as dispersible tablet, slow releasing tablet and effervescent tablet) granule, oral liquid formulation, injection.
Above-mentioned each component is made medicine production method of the present invention is:
The preparation method of tablet (comprising tablets such as dispersible tablet, slow releasing tablet and effervescent tablet), granule is characterized in that:
1. get Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae with 70% alcohol reflux 2h, extracting solution reclaims ethanol, 60 ℃ of oven dry.
2. the residue after the alcohol extraction adds remaining medical material and mixes and decoct with water in the rearmounted multi-function extractor 2 times, each 3h, and merge extractive liquid, concentrates 80 ℃ of oven dry.
3. 1,2 following gained oven dry product is pulverized, mixed, add an amount of excipient and make tablet (comprising tablets such as dispersible tablet, slow releasing tablet and effervescent tablet) or granule.
The preparation method of oral liquid formulation is characterized in that:
Prescription Chinese crude drug mixing and water adding is put in the multi-function extractor and is decocted 2 times, and each 3h collects volatile oil, and is standby.Discard residue.Add 95% ethanol after extracting solution concentrates and make and contain the alcohol amount and reach 40～60%, static 24h, centrifugal, discard precipitation, after supernatant reclaims ethanol, add volatile oil, sucrose is made oral liquid.
The preparation method of injection is characterized in that:
Prescription Chinese crude drug mixing and water adding is put in the multi-function extractor and is decocted 2 times, and each 3h discards residue.Merge extractive liquid,, add 95% ethanol after concentrating and make and contain the alcohol amount and reach 40～50%, static 24h is centrifugal, discard precipitation, supernatant adds 95% ethanol to be made and contains alcohol amount and reach 50～70%, and static 24h is centrifugal, discard precipitation, supernatant adds 95% ethanol to be made and contains alcohol amount and reach 70～80%, reclaim ethanol after, be prepared into injection.
In this preparation method, the extracting solution alcohol precipitation process after concentrating is the gradient precipitate with ethanol, and optium concentration is: contain the alcohol amount for the 1st time and reach and contain the alcohol amount for 50%, the 2 time and reach and contain the alcohol amount 70%, the 3 time and reach 80%.
The end product quality standard of Chinese medicine preparation:
Differentiate: adopt astragaloside, the danshensu in the Radix Salviae Miltiorrhizae and the chrysophanic acid in the Radix Et Rhizoma Rhei in the thin layer chromatography discriminating Radix Astragali.
Assay: adopt the danshensu in the high effective liquid chromatography for measuring monarch drug Radix Salviae Miltiorrhizae, the danshensu sodium reference substance that provides with natural drug teaching and research room of pharmaceutical college of Fudan University compares.Chromatographic column is the octadecylsilane chemically bonded silica post, and mobile phase is that methanol-phosphate buffer (phosphoric acid 0.3ml with sodium dihydrogen phosphate 2g mixing adding distil water to 1000ml) ratio is 5:95, and the detection wavelength is 220nm.Average average recovery is 100.02%, and RSD is 1.68%.
Following animal experiment can prove the drug effect of Chinese medicine preparation of the present invention in the adhesion of control abdominal post-operation.
2 kinds of animal tissue adhesion pathological models are adopted in test, and promptly rat and rabbit tissue adhesion model carry out the whole animal test.Route of administration is oral identical with the clinical application approach.
Medicine of the present invention is to the influence of intestinal adhesion animal the lattice of tabulating as follows.
Table 1 is taken behind the medicine of the present invention in the intestinal adhesion rat tissue in OHP, the blood variation of t-PA level (again ± s)
Annotate: compare with model control group,
*P＜0.05
*P＜0.01
* *P＜0.001 (down together)
Compare #P＜0.05 ##P＜0.01 ###P＜0.001 (down together) with the normal control group
Table 1 result shows: compare with the blank group, model control group ileum and abdominal wall tissue hydroxyproline (OHP) level significantly increase, the tissue plasmin activity factor, (t-PA) significantly reduce (P〉0.001), the success of modeling type is described.Can significantly reduce ileum and abdominal wall tissue OHP level and increase t-PA (P＜0.05) with 2,3 groups of model control group comparative tests, test 1 group and also can significantly reduce abdominal wall tissue OHP and rising t-PA (P＜0.05), but organize the OHP effect not remarkable ileum.
Table 2 is taken behind the medicine of the present invention influence to intestinal adhesion rat intestine adhesion degree
Table 6 result shows: preparation all can significantly alleviate rat postoperative intestinal adhesion degree (P＜0.05～0.01) for 1,2,3 groups.
Table 3 is taken behind the medicine of the present invention influence to intestinal adhesion Sanguis Leporis seu oryctolagi WBC (x ± s)
Table 3 is the result show: compare with the blank group, model control group WBC significantly increases (P＜0.05).Compare with model control group, test 3 groups of amounts and can significantly reduce WBC (P＜0.05), test 1,2 also has reduction, but there was no significant difference.
Table 4 is taken medicine of the present invention to the influence of intestinal adhesion rabbit intestinal and stomach wall OHP (x ± s)
Table 4 is the result show: with the blank group relatively, model control group ileum OHP level significantly raise (P＜0.001).Test 2,3 all can significantly reduce ileum OHP level (P＜0.05～0.01), and to there was no significant difference between each group of influence of stomach wall OHP.
Table 5 is taken behind the medicine of the present invention influence to intestinal adhesion rabbit intestinal adhesion degree
Table 5 is the result show: compare with the blank group, model control group intestinal adhesion degree is (P＜0.01) significantly.Compare with model control group, test 3 can significantly alleviate rabbit postoperative intestinal adhesion degree (P＜0.01).
Below in conjunction with example in detail content of the present invention.
Embodiment 1
The preparation technology of oral liquid formulation is: get Radix Salviae Miltiorrhizae 25kg with 70% alcohol reflux 2 times, each 1h filters filtrate for later use.Medicinal residues and Radix Astragali 25kg, Natrii Sulfas 15kg, Fructus Aurantii 15kg, Radix Angelicae Sinensis 5kg, Radix Aucklandiae 5kg merge, and decocting boils 2 times, and each 3.5h collects Aromatic water 200ml simultaneously, and device is preserved standby in addition.Merge aqueous extract and be concentrated into about 1.17 (50 ℃) of relative density, the ethanol that adds alcohol extract and 95% makes and contains the alcohol amount and reach 60%, and cold preservation 24h is centrifugal.After supernatant reclaimed ethanol, concentrated solution added suitable quantity of water, and cold preservation 24h is centrifugal.Supernatant adds Aromatic water, simple syrup, transfers pH5.0～7.0, and distilled water adds to 1000ml.Filter, embedding, sterilization, promptly.
Embodiment 2
The preparation technology of oral liquid formulation is: get Radix Salviae Miltiorrhizae 15kg with 70% alcohol reflux 2 times, each 1h filters filtrate for later use.Medicinal residues and Radix Astragali 15kg, Natrii Sulfas 5kg, Fructus Aurantii 5kg, Radix Angelicae Sinensis 1kg, Radix Aucklandiae 1kg merge, and decocting boils 2 times, and each 3.5h collects Aromatic water 200ml simultaneously, and device is preserved standby in addition.Merge extractive liquid, is concentrated into about 1.17 (50 ℃) of relative density, and the ethanol that adds alcohol extract and 95% makes and contains the alcohol amount and reach 60%, and cold preservation 24h is centrifugal.After supernatant reclaimed ethanol, concentrated solution added suitable quantity of water, and cold preservation 24h is centrifugal.Supernatant adds Aromatic water, simple syrup, transfers pH5.0～7.0, and distilled water adds to 1000ml.Filter, embedding, sterilization, promptly.
Embodiment 3
The preparation technology of oral liquid formulation is: get Radix Salviae Miltiorrhizae 25kg with 70% alcohol reflux 2 times, each 1h filters filtrate for later use.Medicinal residues and Radix Codonopsis 25kg, Folium Sennae 15kg, Fructus Aurantii 15kg, Rhizoma Cyperi 5kg, Rhizoma Corydalis 5kg merge, and decocting boils 2 times, and each 3.5h collects Aromatic water 200ml simultaneously, and device is preserved standby in addition.Merge aqueous extract and be concentrated into about 1.17 (50 ℃) of relative density, the ethanol that adds alcohol extract and 95% makes and contains the alcohol amount and reach 60%, and cold preservation 24h is centrifugal.After supernatant reclaimed ethanol, concentrated solution added suitable quantity of water, and cold preservation 24h is centrifugal.Supernatant adds Aromatic water, simple syrup, transfers pH5.0～7.0, and distilled water adds to 1000ml.Filter, embedding, sterilization, promptly.
Embodiment 4
The preparation technology of oral liquid formulation is: get Radix Salviae Miltiorrhizae 15kg with 70% alcohol reflux 2 times, each 1h filters filtrate for later use.Medicinal residues and Radix Codonopsis 15kg, Folium Sennae 5kg, Fructus Aurantii 5kg, Rhizoma Cyperi 1kg, Rhizoma Corydalis 1kg merge, and decocting boils 2 times, and each 3.5h collects Aromatic water 200ml simultaneously, and device is preserved standby in addition.Merge aqueous extract and be concentrated into about 1.17 (50 ℃) of relative density, the ethanol that adds alcohol extract and 95% makes and contains the alcohol amount and reach 60%, and cold preservation 24h is centrifugal.After supernatant reclaimed ethanol, concentrated solution added suitable quantity of water, and cold preservation 24h is centrifugal.Supernatant adds Aromatic water, simple syrup, transfers pH5.0～7.0, and distilled water adds to 1000ml.Filter, embedding, sterilization, promptly.
Embodiment 5
The preparation technology of oral liquid formulation is: get Radix Salviae Miltiorrhizae 25kg with 70% alcohol reflux 2 times, each 1h filters filtrate for later use.Medicinal residues and Radix Codonopsis 25kg, Folium Sennae 15kg, Fructus Aurantii 15kg, Radix Angelicae Sinensis 5kg, Cortex Magnoliae Officinalis 5kg merge, and decocting boils 2 times, and each 3.5h collects Aromatic water 200ml simultaneously, and device is preserved standby in addition.Merge aqueous extract and be concentrated into about 1.17 (50 ℃) of relative density, the ethanol that adds alcohol extract and 95% makes and contains the alcohol amount and reach 60%, and cold preservation 24h is centrifugal.After supernatant reclaimed ethanol, concentrated solution added suitable quantity of water, and cold preservation 24h is centrifugal.Supernatant adds Aromatic water, simple syrup, transfers pH5.0～7.0, and distilled water adds to 1000ml.Filter, embedding, sterilization, promptly.
Embodiment 6
The preparation technology of oral liquid formulation is: get Radix Salviae Miltiorrhizae 15kg with 70% alcohol reflux 2 times, each 1h filters filtrate for later use.Medicinal residues and Radix Astragali 15kg, Radix Et Rhizoma Rhei 5kg, Fructus Aurantii 5kg, Radix Angelicae Sinensis 1kg, Cortex Magnoliae Officinalis 1kg merge, and decocting boils 2 times, and each 3.5h collects Aromatic water 200ml simultaneously, and device is preserved standby in addition.Merge extractive liquid, is concentrated into about 1.17 (50 ℃) of relative density, and the ethanol that adds alcohol extract and 95% makes and contains the alcohol amount and reach 60%, and cold preservation 24h is centrifugal.After supernatant reclaimed ethanol, concentrated solution added suitable quantity of water, and cold preservation 24h is centrifugal.Supernatant adds Aromatic water, simple syrup, transfers pH5.0～7.0, and distilled water adds to 1000ml.Filter, embedding, sterilization, promptly.
Embodiment 7
The preparation technology of granule dosage form: get Radix Salviae Miltiorrhizae 25kg, Radix Et Rhizoma Rhei 15kg with 70% alcohol reflux 2 times, each 1h filters filtrate for later use.Radix Astragali 15kg, Fructus Aurantii 5kg, Radix Angelicae Sinensis 1kg, Cortex Magnoliae Officinalis 1kg and Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei medicinal residues add 3,2 times of water gagings respectively and extract in multi-function extractor 2 times, extraction time is respectively the 2.5h merging filtrate, is concentrated into relative density 1.2, mixes with alcohol extract, spray drying, packing.
Embodiment 8
The preparation technology of granule dosage form: get Radix Salviae Miltiorrhizae 15kg, Radix Et Rhizoma Rhei 5kg with 70% alcohol reflux 2 times, each 1h filters filtrate recycling ethanol.Radix Astragali 15kg, Fructus Aurantii Immaturus 5kg, Radix Angelicae Sinensis 1kg, Cortex Magnoliae Officinalis 1kg and Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei residue add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, mixes spray drying, packing with alcohol extract.
Embodiment 9
The preparation technology of granule dosage form: get Radix Salviae Miltiorrhizae 25kg with 70% alcohol reflux 2 times, each 1h filters filtrate recycling ethanol.Radix Codonopsis 25kg, Folium Sennae 15kg, Fructus Aurantii 15kg, Rhizoma Cyperi 5kg, Rhizoma Corydalis 5kg and Radix Salviae Miltiorrhizae residue add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, mixes spray drying, packing with alcohol extract.
Embodiment 10
The preparation technology of granule dosage form: get Radix Salviae Miltiorrhizae 15kg with 70% alcohol reflux 2 times, each 1h filters filtrate recycling ethanol.Radix Codonopsis 15kg, Folium Sennae 5kg, Fructus Aurantii 5kg, Rhizoma Cyperi 1kg, Rhizoma Corydalis 1kg and Radix Salviae Miltiorrhizae residue add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, mixes spray drying, packing with alcohol extract.
Embodiment 11
The preparation technology of granule dosage form: get Radix Salviae Miltiorrhizae 25kg with 70% alcohol reflux 2 times, each 1h filters filtrate recycling ethanol.Radix Astragali 25kg, Natrii Sulfas 15kg, Fructus Aurantii 15kg, Radix Angelicae Sinensis 5kg, Radix Aucklandiae 5kg and Radix Salviae Miltiorrhizae residue add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, mixes spray drying, packing with alcohol extract.
Embodiment 12
The preparation technology of granule dosage form: get Radix Salviae Miltiorrhizae 15kg with 70% alcohol reflux 2 times, each 1h filters filtrate recycling ethanol.Radix Astragali 15kg, Natrii Sulfas 5kg, Fructus Aurantii 5kg, Radix Angelicae Sinensis 1kg, Radix Aucklandiae 1kg and Radix Salviae Miltiorrhizae residue add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, mixes spray drying, packing with alcohol extract.
Embodiment 13
The preparation technology of injection type: get each 25kg of Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei 15kg, Cortex Magnoliae Officinalis 5kg add 2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, adds 95% ethanol and makes medicinal liquid contain the alcohol amount to reach 50%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 60%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 70%, leave standstill 24h, centrifugal removal precipitation.Reclaim ethanol.An amount of cold preservation 24h of medicinal liquid adding distil water, centrifugal, supernatant is transferred pH, adds 1% active carbon, boils 30min, cold after-filtration, filtrate is added water for injection makes into full dose, packing, sterilization, promptly.
Embodiment 14
The preparation technology of injection type: get each 15kg of Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei 5kg, Cortex Magnoliae Officinalis 1kg add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, adds 95% ethanol and makes medicinal liquid contain the alcohol amount to reach 50%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 60%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 70%, leave standstill 24h, centrifugal removal precipitation.Reclaim ethanol.An amount of cold preservation 24h of medicinal liquid adding distil water, centrifugal, supernatant is transferred pH, adds 1% active carbon, boils 30min, cold after-filtration, filtrate is added water for injection makes into full dose, packing, sterilization, promptly.
Embodiment 15
The preparation technology of injection type: get each 15kg of Radix Salviae Miltiorrhizae, Folium Sennae 15kg, Fructus Aurantii Immaturus 5kg add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, adds 95% ethanol and makes medicinal liquid contain the alcohol amount to reach 50%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 60%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 70%, leave standstill 24h, centrifugal removal precipitation.Reclaim ethanol.An amount of cold preservation 24h of medicinal liquid adding distil water, centrifugal, supernatant is transferred pH, adds 1% active carbon, boils 30min, cold after-filtration, filtrate is added water for injection makes into full dose, packing, sterilization, promptly.
Embodiment 16
The preparation technology of injection type: get each 15kg of Radix Salviae Miltiorrhizae, Folium Sennae 5kg, Fructus Aurantii Immaturus 1kg add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, adds 95% ethanol and makes medicinal liquid contain the alcohol amount to reach 50%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 60%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 70%, leave standstill 24h, centrifugal removal precipitation.Reclaim ethanol.An amount of cold preservation 24h of medicinal liquid adding distil water, centrifugal, supernatant is transferred pH, adds 1% active carbon, boils 30min, cold after-filtration, filtrate is added water for injection makes into full dose, packing, sterilization, promptly.
Embodiment 17
The preparation technology of injection type: get each 15kg of Radix Salviae Miltiorrhizae, Natrii Sulfas 15kg, Radix Aucklandiae 5kg add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, adds 95% ethanol and makes medicinal liquid contain the alcohol amount to reach 50%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 60%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 70%, leave standstill 24h, centrifugal removal precipitation.Reclaim ethanol.An amount of cold preservation 24h of medicinal liquid adding distil water, centrifugal, supernatant is transferred pH, adds 1% active carbon, boils 30min, cold after-filtration, filtrate is added water for injection makes into full dose, packing, sterilization, promptly.
Embodiment 18
The preparation technology of injection type: get each 15kg of Radix Salviae Miltiorrhizae, Natrii Sulfas 5kg, Radix Aucklandiae 1kg add 3,2 times of water gagings respectively and extract 2 times in multi-function extractor, and extraction time is respectively 2.5h.Merging filtrate is concentrated into relative density 1.2, adds 95% ethanol and makes medicinal liquid contain the alcohol amount to reach 50%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 60%, leave standstill 24h, centrifugal removal precipitation.Supernatant adds 95% ethanol.Make medicinal liquid contain the alcohol amount and reach 70%, leave standstill 24h, centrifugal removal precipitation.Reclaim ethanol.An amount of cold preservation 24h of medicinal liquid adding distil water, centrifugal, supernatant is transferred pH, adds 1% active carbon, boils 30min, cold after-filtration, filtrate is added water for injection makes into full dose, packing, sterilization, promptly.
The invention discloses a kind of medicine for the treatment of abdomen pelvic disease postoperative intestinal adhesion and its production and use.This medicine is the Chinese medicine pharmaceutical composition, is principal agent with Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae and the Radix Astragali, is equipped with other supplementary material and makes, and is applied to treat abdomen pelvic disease postoperative intestinal adhesion.
Claims (12)
1, a kind of Chinese medicine preparation that is used to prevent and treat tissue adhesion is characterized in that following Chinese medicine makes by important portion rate: the Radix Astragali 15～25, Radix Salviae Miltiorrhizae 15～25, Radix Et Rhizoma Rhei 5～15, Fructus Aurantii Immaturus 5～15, Radix Angelicae Sinensis 1～5, Cortex Magnoliae Officinalis 1～5.
2, a kind of Chinese medicine preparation that is used to prevent and treat tissue adhesion is characterized in that following Chinese medicine makes by important portion rate: Radix Codonopsis 15～25, Radix Salviae Miltiorrhizae 15～25, Folium Sennae 5～15, Fructus Aurantii 5～15, Rhizoma Cyperi 1～5, Rhizoma Corydalis 1～5.
3, a kind of Chinese medicine preparation that is used to prevent and treat tissue adhesion is characterized in that following Chinese medicine makes by important portion rate: the Radix Astragali 15～25, Radix Salviae Miltiorrhizae 15～25, Natrii Sulfas 5～15, Fructus Aurantii 5～15, Radix Angelicae Sinensis 1～5, the Radix Aucklandiae 1～5.
4, a kind of Chinese medicine preparation that is used to prevent and treat tissue adhesion is characterized in that following Chinese medicine makes by important portion rate: Radix Salviae Miltiorrhizae 15～25, Radix Et Rhizoma Rhei 5～15, Fructus Aurantii Immaturus 5～15.
5, a kind of Chinese medicine preparation that is used to prevent and treat tissue adhesion is characterized in that following Chinese medicine makes by important portion rate: Radix Salviae Miltiorrhizae 15～25, Folium Sennae 5～15, Fructus Aurantii 5～15.
6, a kind of Chinese medicine preparation that is used to prevent and treat tissue adhesion is characterized in that following Chinese medicine makes by important portion rate: Radix Salviae Miltiorrhizae 15～25, Natrii Sulfas 5～15, the Radix Aucklandiae 1～5.
7,, it is characterized in that described preparation is tablet (comprising tablets such as dispersible tablet, slow releasing tablet and effervescent tablet), granule according to claim 1,2,3 described Chinese medicine preparation.
8,, it is characterized in that described preparation is an oral solutions according to claim 1,2,3 described Chinese medicine preparation.
9,, it is characterized in that described preparation is an injection according to claim 4,5,6 described Chinese medicine preparation.
10, the preparation method of Chinese medicine preparation according to claim 7 is characterized in that:
A. Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae 70% ethanol extraction, extracting solution reclaims ethanol, cold drying.
B. the residue after the alcohol extraction adds remaining medical material decocting and boils, and aqueous extract concentrates, oven dry.
C. gained oven dry product under A, the B item are mixed, pulverize, make tablet or electuary.
11, the preparation method of Chinese medicine preparation according to claim 8 is characterized in that: prescription Chinese crude drug mixing and water adding decocts, and collects volatile oil, and is standby.Discard residue.Add 95% ethanol after extracting solution concentrates and make and contain the alcohol amount and reach 40～60%, static 24h, centrifugal, discard precipitation, after supernatant reclaims ethanol, add volatile oil, make oral liquid.
12, the preparation method of Chinese medicine preparation according to claim 9 is characterized in that: prescription Chinese crude drug mixing and water adding decocts, and discards residue.Adding 95% ethanol after extracting solution concentrates makes and contains the alcohol amount and reach 40～50%, static 24h, centrifugal, discard precipitation, supernatant adds 95% ethanol to be made and contains alcohol amount and reach 50～70%, static 24h, centrifugal, discard precipitation, supernatant adds 95% ethanol to be made and contains alcohol amount and reach 70～80%, after reclaiming ethanol, be prepared into injection.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101971991A CN101450133A (en) | 2007-12-07 | 2007-12-07 | Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101971991A CN101450133A (en) | 2007-12-07 | 2007-12-07 | Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion |
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| CNA2007101971991A Pending CN101450133A (en) | 2007-12-07 | 2007-12-07 | Medicine for treating abdominopelvic cavity disease postoperative intestinal adhesion |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893288A (en) * | 2014-04-12 | 2014-07-02 | 蚌埠火鹤制药有限公司 | Chinese medicinal formula for treating constipation |
| CN110075176A (en) * | 2019-05-29 | 2019-08-02 | 南方医科大学南方医院 | It is a kind of for treating the Chinese medicine composition and application thereof of abdomen pelvic conditions post-operation adhesion |
-
2007
- 2007-12-07 CN CNA2007101971991A patent/CN101450133A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893288A (en) * | 2014-04-12 | 2014-07-02 | 蚌埠火鹤制药有限公司 | Chinese medicinal formula for treating constipation |
| CN110075176A (en) * | 2019-05-29 | 2019-08-02 | 南方医科大学南方医院 | It is a kind of for treating the Chinese medicine composition and application thereof of abdomen pelvic conditions post-operation adhesion |
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