CN101249223A - Chinese native medicine and western medicine compound preparations for curing coryza cold - Google Patents
Chinese native medicine and western medicine compound preparations for curing coryza cold Download PDFInfo
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Abstract
The invention discloses a Chinese and western medicine compound preparation for curing cold, which is composed of ten species of Chinese and western medicine materials, such as honey suckle, forsythia fruit, herb of wild mint, herba schizonepetae, fermented soybean, achene of creat burdock, balloonflower root, henom bamboo leaf, licorice root and acetaminopher. The invention is verified through the clinical effect safety evaluation to be safe and effective to the treatment of cold. The invention discloses a preparing method.
Description
Technical field:
The present invention relates to Chinese medicine preparation, be specifically related to a kind of compound preparation for the treatment of Common Cold and preparation method thereof.
Background technology:
Flu is commonly called as " cold ", is owing to multiple virus (rhinovirus, coronavirus, influenza A and anomaly etc.) infects the upper respiratory tract acute inflammation that causes.All can fall ill throughout the year, much more comparatively see in You Yidong, spring.Flu is divided into upper respiratory tract infection (going up sense) and influenza (influenza), and is strong with the latter's infectiousness, propagates rapidly.Flu is again a kind of commonly encountered diseases, frequently-occurring disease, because the idea of common customs thinks that flu does not include disease and delay treatment, so that influences people's health level.For the different infants and the different phase of the course of disease, the flu light and heavy degree has very big difference, and general youngster occurring degree is lighter, and old man and infant then serious symptom are more; Because the flu onset is lighter in early days, delay treatment then can cause comparatively severe complications, as otitis media, septicemia etc.Thereby be still the problem that needs research for the treatment of flu.
The treatment of flu is intended to remove nasal mucosa hyperemia, alleviates the swelling of blood capillary in the nasal cavity and alleviates the nasal obstruction sense, reduces nasal discharge.Help to keep pharyngotympanic tube and hole mouth unimpeded in addition, thereby prevent secondary infection.Because the flu morbidity is rapid, the symptom complexity is various, and therefore, the treatment coldrex adopts compound preparation more.
Many in the prescription collocation commonly used at present based on chemicals, as: antipyretic analgesic, nasal mucosa vasoconstriction, histamine antagonist, central stimulants, antiviral agents etc., but these medicines are controlled table often, can not solve its root problem.Therefore, seek to control double the effecting a permanent cure of table, the Chinese medicine that table is originally taken into account has become the research topic of paying close attention to, and the pure Chinese medicinal preparation or the bonded coldrex of Chinese medicine and western medicine of some treatment flu are also arisen at the historic moment, but the effect of these medicines is also undesirable.Therefore, seeking more, the rational and effective Chinese medicine preparation is the direction with Practical significance research.
Summary of the invention:
The technical problem to be solved in the present invention is to overcome above-mentioned weak point, the Chinese medicine and western medicine compound preparation of the treatment Common Cold that a kind of good effect of research design, side effect are little.
The invention provides a kind of Chinese medicine and western medicine compound preparation for the treatment of Common Cold.
Chinese medicine and western medicine compound preparation of the present invention has the Chinese medicine and western medicine raw material constituent of following percentage by weight:
Flos Lonicerae 1.51%～28.67, Fructus Forsythiae 1.51%～28.67%, Herba Menthae 0.91%～17.20%, Herba Schizonepetae 0.60%～11.48, Semen Sojae Preparatum 0.75%～14.33%, Fructus Arctii 0.91%～17.20%, Radix Platycodonis 0.91%～17.20%, Herba Lophatheri 0.60%～11.48%, Radix Glycyrrhizae 0.75%～14.33%, acetaminophen 1.55%～29.46%.Or;
Chinese medicine and western medicine compound preparation of the present invention has the Chinese medicine and western medicine raw material constituent of following percentage by weight:
Flos Lonicerae 13.58%～16.60%, Fructus Forsythiae 13.58%～16.60%, Herba Menthae 8.15%～9.96%, Herba Schizonepetae 5.43%～6.64%, Semen Sojae Preparatum 6.79%～8.30%, Fructus Arctii 8.15%～9.96%, Radix Platycodonis 8.15%～9.96%, Herba Lophatheri 5.44%～6.64%, Radix Glycyrrhizae 6.79%～8.29%, acetaminophen 13.96%～17.06%.
Prescription of the present invention is with relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, and the Flos Lonicerae of heat-clearing and toxic substances removing, Fructus Forsythiae are monarch drug; Radix Platycodonis, Fructus Arctii using pungent drugs for dispersion and bitter drugs for purgation lung qi, sliding throat is ministerial drug; Surplus medicine is an adjuvant, and Herba Schizonepetae, Herba Menthae, Semen Sojae Preparatum dispelling wind and heat pathogens assist Flos Lonicerae, Fructus Forsythiae to eliminate the etiological treatment primary symptom, Herba Lophatheri, Radix Glycyrrhizae heat clearing away, the double disease of holding under the arm of treatment of promoting the production of body fluid, quench the thirst.It is strong that acetaminophen is separated heating power.Full side's mutual aid reaches dispelling wind and heat pathogens, heat-clearing and toxic substances removing, the effect of treatment Common Cold.
Another object of the present invention has provided a kind of preparation method for the treatment of Common Cold Chinese medicine and western medicine compound preparation.
The inventive method comprises the following steps:
(1) extracts
(1) extracting honeysuckle is put in the extractor, by weight/volume ratio, add the water of 8 times of amounts the first time, add the water of 6 times of amounts for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, extracted twice liquid is merged, centrifugal filtration gets A liquid;
(2) get Herba Schizonepetae, Herba Menthae, put respectively that to add an amount of water in the extractor moistening, adopt steam distillation to extract volatile oil, get Herba Schizonepetae oil, Oleum menthae, medicinal residues merge are decocted 2 times, by weight/volume ratio, add for the first time 8 times of amounts water, add the water of 6 times of amounts for the second time, decoct twice, decocted 1.5 hours for the first time, decocted 1 hour for the second time, merge extracted twice liquid, centrifugal filtration gets B liquid;
(3) get Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Fructus Arctii, Radix Platycodonis (total amount 3.5%), decoct with water and extract twice, by weight/volume ratio, the water that adds for the first time 8 times of amounts, add the water of 6 times of amounts the second time, decocted 2 hours at every turn, merge extracted twice liquid, filter, get C liquid;
(4) get Semen Sojae Preparatum and put in the extractor, by weight/volume ratio, add the water of 8 times of amounts the first time, add the water of 6 times of amounts for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, merge extracted twice liquid, filter, boiled 40 minutes in normal pressure, get D liquid;
(5) get above-mentioned A, B, C, the merging of D liquid, be concentrated into 2.2% of original volume, relative density is 1.20～1.26 (double dilution method surveys), promptly gets extractum;
(2) pulverize, sterilize
Get the Radix Platycodonis total amount 97%, acetaminophen, and pulverize total amount by medicine, add 14% sucrose and 2% Paris white and be broken into fine powder, cross 100 mesh sieves, put in the mixer behind the mix homogeneously, pack in the clean cloth bag, use ethylene oxide sterilizing, get fine powder;
(3) preparation granule
Get sterilization back fine powder and put in the granulator, other gets step (5) extractum and adds as binding agent in 10: 1 ratio dilute with waters, puts in the granulator and mixes, do timing by the granule total amount, add 1% magnesium stearate, spray into 0.05% Herba Schizonepetae oil and 0.05% Oleum menthae, the preparation granule;
(4) make preparation
The granule and the pharmaceutic adjuvant of step (three) are made preparation.
Chinese medicine and western medicine compound preparation of the present invention can be made oral tablet, capsule, oral liquid, granule or powder etc. according to a conventional method with pharmaceutic adjuvant.
The compound Chinese medicinal preparation that the present invention treats flu has relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, the effect of antipyretic-antalgic is as follows through clinical efficacy and safety evaluatio result:
One, case source: all case derives from HuaZhong Science University, TongJi medical school, TongJi Hospital, Wuhan No.4 Hospital and the hospital of traditional Chinese hospital, Wuhan City etc.Hospital's department of Chinese medicine, internal medicine outpatient service and inpatient are according to Chinese medical discrimination diagnostic criteria and the Western medicine diagnose standard in " the clinical research guideline of new Chinese medicine treatment flu ".Selected observation case all meets above-mentioned diagnostic criteria, the age: 18-65 is between year.
Two, physical data: this group case is through internal medicine or department of Chinese medicine inspection, and diagnosis upper respiratory tract infection mainly by the popular contact history of flu is arranged, has the dry pharynx pharyngalgia, nasal obstruction sneeze, watery nasal discharge, cough, heating, headache, systemic pain, symptoms such as weak poor appetite.Meet simultaneously Chinese medical discrimination belong to 1. wind-heat syndrome (fever of the body is more outstanding, and micro evil wind, antiperspirant are let out not smooth, distending pain in the head, cough, expectorant is sticking or yellow, parched throat, or red swelling and pain of throat, nasal obstruction, stream turbid nasal discharge, thirst with desire to drink, tongue tip side of red, the little Huang of thin white fur of tongue, floating and rapid pulse.) 2. syndrome of summer-heat-dampness (sweating is not smooth for fever of the body, micro evil wind, vague aching of limbs or pain, dizzy and headache, cough with ropy sputum, turbid nasal discharge, restlessness and thirst, or mouthful in sticky, polydipsia not is uncomfortable in chest yearningly, nausea, oliguria with reddish urine, tongue fur BOHUANG and be bored with soft and rapid pulse.)
Observed patient is divided into two groups at random: treatment group (powerful common cold tablet group) 304 examples, matched group (Vc YINQIAO sheet group) 100 examples.Two groups of cases are learned by statistics and are handled equal no significant difference at aspects such as sex, age, the course of disease and Chinese medical discrimination typings, and comparability (seeing Table 1-2) is arranged
Table 1 liang group sex, mean age, average course of disease situation are relatively
Annotate: relatively, P all＞0.05 between group
Table 2 liang group case Chinese medical discrimination typing distribution situation is (X relatively
2)
Annotate: between group relatively, P all＞0.05, two group between traditional Chinese medical science typing distribution-free difference.
Three, case choice criteria
(1) diagnostic criteria
1, Western medicine diagnose standard
Diagnosis upper respiratory tract infection is mainly by there being the popular contact history of catching a cold, clinical manifestation, and x line finding and numeration of leukocyte, and to the reaction of antibiotic therapy.
(1) clinical manifestation: dry pharynx pharyngalgia, nasal obstruction sneeze, watery nasal discharge, cough, heating, headache, systemic pain, weak poor appetite etc.
(2) numeration of leukocyte is normal or on the low side.
(3) inspection such as immunofluorescence virus separation can be determined etiological diagnosis.
2, Chinese medical discrimination standard
(1) wind-heat syndrome
Fever of the body is more outstanding, and micro evil wind, antiperspirant are let out not smooth, distending pain in the head, and cough, expectorant is sticking or yellow, parched throat, or red swelling and pain of throat, nasal obstruction, stream turbid nasal discharge, thirst with desire to drink, tongue tip side of red, the little Huang of thin white fur of tongue, floating and rapid pulse.
(2) syndrome of summer-heat-dampness
Fever of the body, micro evil wind, sweating is not smooth, vague aching of limbs or pain, dizzy and headache, cough with ropy sputum, turbid nasal discharge, restlessness and thirst, or mouthful in sticky, polydipsia not is uncomfortable in chest yearningly, nausea, oliguria with reddish urine, tongue fur BOHUANG and be bored with soft and rapid pulse.
3, include the case standard in
In meeting, Western medicine diagnose standard and Chinese medical discrimination, body temperature is more than 38 ℃, the course of disease is the person within 48 hours, can include the test case in.
4, get rid of the case standard
(1) used the medicine person.
(2) age under-18s or 65 years old and, gestation and women breast-feeding their children, allergic constitution and to this medicine allergy sufferers.
(3) merge serious primary disease person such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system, psychotic.
(4) do not meet the standard of including in, not medication in accordance with regulations can't be judged curative effect, or data is not congruent affects the treatment or safety judgement person.
Therapeutic Method
One, observation index
1, safety observation
(1) general physical examination project.
(2) blood, the urine inspection that just routinizes.
(3) heart, liver, kidney function test.
2, health giving quality observation
(1) observation of symptoms: nasal obstruction watery nasal discharge, sneeze, cough, headache, fever with aversion to cold, general malaise etc.
(2) temperature taking, every day 2-3 time.
(3) picture of the tongue, pulse condition.
(4) total white blood cells adds classification.
Two, efficacy assessment standard
Be divided into recovery from illness, produce effects, standard such as effective and invalid according to " new Chinese medicine treatment flu clinical research guideline ".
1, the recovery from illness: treat 3 days normal with interior temperature recovery, the symptom of flu all disappears.
2, produce effects: treat 3 days normal with body temperature, most of transference cure of flu.
3, effective: treat and reduced than before with interior body temperature in 3 days, the cardinal symptom of flu partly disappears.
4, invalid: treat and do not fall with interior body temperature or raise in 3 days, the cardinal symptom of flu does not have improvement.
Three, method of administration
Include standard in and reject the Standard Selection case according to case in " the clinical research guideline that the new Chinese medicine treatment is caught a cold ", include in and observe inactive earlier other treatment coldrex of case, be divided into treatment group and matched group at random.
(1) treatment group
1, is subjected to the reagent thing
Title: powerful common cold tablet
Source: Wuhan Zhonglian Pharmaceutical Group Co. Ltd.
Specification: 0.5 gram/sheet
Lot number: 000601
Preservation condition: sealing, put shady and cool dry place.
2, dosage regimen
Dosage: one time 2,3 times on the one
The course of treatment: 7 days is a course of treatment
Usage: oral
(2) matched group
1, is subjected to the reagent thing
Title: Vc YINQIAO sheet
Source: Hubei Minkang Pharmaceutical Co., Ltd
Specification: 18 slices/bag
Lot number: 020402
Preservation condition: sealing, protection against the tide.
2, dosage regimen
Dosage: one time 4,3 times on the one
The course of treatment: 7 days is a course of treatment
Usage: oral
Every routine patient all observes safety observation project before and after the treatment, other curative of stopping using during the clinical observation.Patient's further consultation weekly once writes down main clinic symptoms and improves situation and relevant medication untoward reaction, finishes the back check course of treatment about checking index.
Therapeutic outcome
Statistical processing methods: the grade classified data is analyzed with Ridit, enumeration data X
2Check, measurement data is checked with t.
One, two groups of total clinical efficacies relatively
Powerful common cold tablet group (treatment group) is improved its 62 examples of fully recovering of cold symptoms, accounts for 20.39%, and its produce effects 103 examples account for 33.88%, and effective 115 examples account for 37.78%, and invalid 24 examples occupy 7.89%, and total effective rate is 280 examples, accounts for 92.10%; Vc YINQIAO sheet (matched group) should be recovery from illness 6 examples mutually, accounts for 6%, produce effects 44 examples (44.0%), and effective 40 examples (40%), invalid 16 examples (16.0%), total effective rate is 84.0%.Two groups are compared no significant difference (P＞0.05), see Table 3
The table 3 liang clinical total effects of group treatment flu is (X relatively
2)
Annotate: two groups are compared P＞0.05.
Two, two groups of main clinic symptoms and the comparative analysis of sign curative effect
The main clinic symptoms curative effects such as watery nasal discharge, sneeze, cough, headache, fever with aversion to cold, general malaise of having a stuffy nose after two groups of Drug therapys relatively see Table 4
The curative effect that table 4 pair cardinal symptom sign is improved is (X relatively
2)
Annotate: two groups are compared P
All＞0.05, relatively there was no significant difference of two groups of group symptom curative effects is described.
Three, two groups of different TCM Syndrome Type efficacy analysis relatively
Two groups of TCM Syndrome Type wind-heat syndromes, syndrome of summer-heat-dampness curative effects relatively see Table 5
The table 5 liang different TCM Syndrome Type curative effects of group are (X relatively
2)
Annotate: two groups are compared P
All＞0.05, relatively there was no significant difference of two groups of medicine pattern of syndrome curative effects is described.
Four, change before and after the safety indexes treatment
All observe routine blood test, routine urinalysis, stool routine examination, hepatic and renal function and Electrocardioscopy before and after two groups of treatments.The results are shown in Table 6, table 7, table 8
Routine blood test result comparison before and after the table 6 liang group treatment (X ± S)
Annotate: two groups are compared * P before and after the treatment
All＜0.05, powerful common cold tablet has the WBC of falling and classification effect.
Routine urinalysis, stool routine examination and electrocardiogram result compare (X before and after the table 7 liang group treatment
2)
Annotate: compare P before and after two groups of treatments
All＞0.05, safety indexes there is not influence.
Before and after the treatment of table 8 liang group liver, renal function result relatively (X ± S),
Annotate: compare P before and after two treatments
All＞0.05.
Five, the untoward reaction of taking medicine
Two groups of patients there is no digestive tract irritant reaction and skin allergy symptom in period in a medicine three tame hospitals.Illustrate that powerful common cold tablet treatment acute upper respiratory tract infection (flu) is oral safe and effective.
Conclusion
1, powerful common cold tablet treatment acute upper respiratory tract infection (flu) total effective rate is 92.10%, and cure rate is 20.39%.Matched group (Vc YINQIAO sheet) is respectively 90.00% and 6.00%.Learn more by statistics for two groups and handle there was no significant difference P＞0.05.
2, powerful common cold tablet is good to the curative effect of improving acute upper respiratory tract infection (flu) main clinic symptoms nasal obstruction watery nasal discharge, sneeze, cough, headache, fever with aversion to cold, general malaise etc.Wherein better to fever with aversion to cold, sneeze, headache curative effect, be respectively 93.42%, 90.90% and 90.14%, be excellent than Vc YINQIAO sheet.
3, as seen from Table 5, powerful common cold tablet is excellent to the wind-heat syndrome curative effect, reaches 92.22%, is 89.10% to the syndrome of summer-heat-dampness curative effect, all no difference of science of statistics (P＞0.05) to different TCM Syndrome Type efficacy analysis.
4, to the influence of safety indexes: during the powerful common cold tablet treatment blood, urine, stool routine examination, hepatic and renal function and electrocardiogram are not all had influence.
5, period in a medicine does not find that powerful common cold tablet has any digestive tract stimulation and skin allergy, illustrates that powerful common cold tablet treatment acute upper respiratory tract infection (flu) is safe and effective.
The specific embodiment:
Example 1: the preparation of powerful common cold tablet
Prescription:
Flos Lonicerae 144kg Fructus Forsythiae 144kg Herba Menthae 86.4kg Herba Schizonepetae 57.6kg
Semen Sojae Preparatum 72kg Fructus Arctii 86.4kg Radix Platycodonis 86.4kg Herba Lophatheri 57.6kg
Radix Glycyrrhizae 72kg acetaminophen 148kg
Preparation
(1) extracts
(1) extracting honeysuckle is put in the extractor, adds the water of 1152kg for the first time, adds the water of 864kg for the second time, in 70～80 ℃ of warm macerating twice, and each 2 hours, extracted twice liquid is merged, centrifugal filtration gets A liquid (1900kg);
(2) get Herba Schizonepetae, Herba Menthae, put respectively that to add an amount of water in the extractor moistening, adopt steam distillation to extract volatile oil, Herba Schizonepetae oil, Oleum menthae, medicinal residues are merged decoction 2 times, add for the first time 1152kg water, add the water of 864kg for the second time, decoct twice, decocted 1.5 hours for the first time, decocted 1 hour for the second time, merge extracted twice liquid, centrifugal filtration gets B liquid (1900kg);
(3) get Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Fructus Arctii, Radix Platycodonis (total amount 3.5%), decoct with water and extract twice, add the water of 2904kg for the first time, add the water of 2178kg for the second time, decocted 2 hours at every turn, merge extracted twice liquid, filter, C liquid (4800kg);
(4) get Semen Sojae Preparatum and put in the extractor, add the water of 576kg for the first time, add the water of 432kg for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, merge extracted twice liquid, filter, boiled 40 minutes in normal pressure, get D liquid (900kg);
(5) get above-mentioned A, B, C, the merging of D liquid, be concentrated into 2.2% of original volume, relative density is 1.20～1.26 (double dilution method surveys), promptly gets extractum;
(2) pulverize, sterilize
Get 83.4kg Radix Platycodonis, acetaminophen, sucrose 32.5kg, calcium carbonate 5kg.Pulverize, cross 100 mesh sieves, put in the mixer behind the mix homogeneously, pack in the clean cloth bag, use ethylene oxide sterilizing, must fine powder;
(3) preparation granule
Get sterilization back fine powder and insert in the one-step-granulating method, get extractum 250kg in 10: 1 ratio dilute with waters as binding agent, mix; do timing and add the .3.6kg magnesium stearate; spray into Herba Schizonepetae oil 175ml and Oleum menthae 170ml, be pressed into 0.5g heavy slice, thin piece, coating, make finished product.Every contains acetaminophen 180-220mg.
Example 2: the preparation of powerful cold relief capsule
Prescription:
Flos Lonicerae 144kg Fructus Forsythiae 144kg Herba Menthae 86.4kg Herba Schizonepetae 57.6kg
Semen Sojae Preparatum 72kg Fructus Arctii 86.4kg Radix Platycodonis 86.4kg Herba Lophatheri 57.6kg
Radix Glycyrrhizae 72kg acetaminophen 148kg
Preparation
(1) extracts
(1) extracting honeysuckle is put in the extractor, adds the water of 1152kg for the first time, adds the water of 864kg for the second time, in 70～80 ℃ of warm macerating twice, and each 2 hours, extracted twice liquid is merged, centrifugal filtration gets A liquid (1900kg);
(2) get Herba Schizonepetae, Herba Menthae, put respectively that to add 300kg water in the extractor moistening, adopt steam distillation to extract volatile oil, Herba Schizonepetae oil, Oleum menthae, medicinal residues are merged decoction 2 times, add for the first time 1152kg water, add the water of 864kg for the second time, decoct twice, decocted 1.5 hours for the first time, decocted 1 hour for the second time, merge extracted twice liquid, centrifugal filtration gets B liquid (1900kg);
(3) get Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Fructus Arctii, Radix Platycodonis (total amount 3.5%), decoct with water and extract twice, add the water of 2904kg for the first time, add the water of 2178kg for the second time, decocted 2 hours at every turn, merge extracted twice liquid, filter, C liquid (4800kg);
(4) get Semen Sojae Preparatum and put in the extractor, add the water of 576kg for the first time, add the water of 432kg for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, merge extracted twice liquid, filter, boiled 40 minutes in normal pressure, get D liquid (900kg);
(5) get above-mentioned A, B, C, the merging of D liquid, be concentrated into 2.2% of original volume, relative density is 1.20～1.26 (double dilution method surveys), promptly gets extractum;
(2) pulverize, sterilize
Get 83.4kg Radix Platycodonis, acetaminophen, sucrose 37.5kg.Pulverize, cross 100 mesh sieves, put in the mixer behind the mix homogeneously, pack in the clean cloth bag, use ethylene oxide sterilizing, must fine powder;
(3) granulation, encapsulated
Get sterilization back fine powder and put in the one-step-granulating method, get extractum 250kg and granulate as binding agent in 10: 1 ratio dilute with waters, spray into Herba Schizonepetae oil 175ml and Oleum menthae 170ml, incapsulate, every 0.5g makes finished product.Every contains acetaminophen 180-220mg.
3: the syrupy preparation of powerful flu
Prescription:
Flos Lonicerae 48kg Fructus Forsythiae 48kg Herba Menthae 28.8kg Herba Schizonepetae 19.2kg
Semen Sojae Preparatum 24kg Fructus Arctii 28.8kg Radix Platycodonis 28.8kg Herba Lophatheri 19.2kg
Radix Glycyrrhizae 24kg acetaminophen 49.33kg
Preparation
(1) extracts
(1) extracting honeysuckle is put in the extractor, adds the water of 384kg for the first time, adds the water of 288kg for the second time, in 70～80 ℃ of warm macerating twice, and each 2 hours, extracted twice liquid is merged, centrifugal filtration gets A liquid (640kg);
(2) get Herba Schizonepetae, Herba Menthae, it is moistening to put the water that adds 300kg in the extractor respectively, adopts steam distillation to extract volatile oil, gets Herba Schizonepetae oil, Oleum menthae, medicinal residues are merged decoction 2 times, add for the first time 384kg water, add the water of 288kg for the second time, decoct twice, decocted 1.5 hours for the first time, decocted 1 hour for the second time, merge extracted twice liquid, centrifugal filtration gets B liquid (640kg);
(3) get Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Fructus Arctii, Radix Platycodonis, decoct with water extraction twice, add the water of 1190kg for the first time, add the water of 893kg for the second time, decocted 2 hours at every turn, merge extracted twice liquid, filter, get C liquid (2000kg);
(4) get Semen Sojae Preparatum and put in the extractor, add the water of 192kg for the first time, add the water of 144kg for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, merge extracted twice liquid, filter, boiled 40 minutes in normal pressure, get D liquid (300kg);
(5) get above-mentioned A, B, C, the merging of D liquid, leave standstill, get supernatant, add acetaminophen, 900kg sugarcane candy and 3.6kg sodium benzoate, stirring makes dissolving, boils 30 minutes, and cold back adds Herba Schizonepetae oil 58ml and Oleum menthae 57ml mix homogeneously, adjust volume to 1200L, fill, every bottle of 100ml.Make finished product.Every 10ml contains acetaminophen 360-440mg.
4: the preparation of powerful cold granules agent
Prescription:
Flos Lonicerae 48kg Fructus Forsythiae 48kg Herba Menthae 28.8kg Herba Schizonepetae 19.2kg
Semen Sojae Preparatum 24kg Fructus Arctii 28.8kg Radix Platycodonis 28.8kg Herba Lophatheri 19.2kg
Radix Glycyrrhizae 24kg acetaminophen 49.33kg
Preparation
(1) extracts
(1) extracting honeysuckle is put in the extractor, adds the water of 384kg for the first time, adds the water of 288kg for the second time, in 70～80 ℃ of warm macerating twice, and each 2 hours, extracted twice liquid is merged, centrifugal filtration gets A liquid (about 640kg);
(2) get Herba Schizonepetae, Herba Menthae, it is moistening to put the water that adds 300kg in the extractor respectively, adopts steam distillation to extract volatile oil, gets Herba Schizonepetae oil, Oleum menthae, medicinal residues are merged decoction 2 times, add for the first time 384kg water, add the water of 288kg for the second time, decoct twice, decocted 1.5 hours for the first time, decocted 1 hour for the second time, merge extracted twice liquid, centrifugal filtration gets B liquid (640kg);
(3) get Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Fructus Arctii, Radix Platycodonis, decoct with water extraction twice, add the water of 1190kg for the first time, add the water of 893kg for the second time, decocted 2 hours at every turn, merge extracted twice liquid, filter, get C liquid (2000kg);
(4) get Semen Sojae Preparatum and put in the extractor, add the water of 192kg for the first time, add the water of 144kg for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, merge extracted twice liquid, filter, boiled 40 minutes in normal pressure, get D liquid (300kg);
(5) get above-mentioned A, B, C, the merging of D liquid, be concentrated into 2.2% of original volume, relative density is 1.30～1.32 (double dilution method surveys), promptly gets extractum;
Two granulate
Get acetaminophen 49.33kg, extractum 90kg, by the extractum amount, add the about 520kg granulation of Icing Sugar that 5.5-6 doubly measures, drying sprays into Herba Schizonepetae oil 58ml and Oleum menthae 57ml, makes finished granule.Every packed 5g, every 5g contains acetaminophen 360-440mg.
5: the preparation of powerful flu powder
Prescription:
Flos Lonicerae 144kg Fructus Forsythiae 144kg Herba Menthae 86.4kg Herba Schizonepetae 57.6kg
Semen Sojae Preparatum 72kg Fructus Arctii 86.4kg Radix Platycodonis 86.4kg Herba Lophatheri 57.6kg
Radix Glycyrrhizae 72kg acetaminophen 148kg
Preparation
1, extracts
(1) gets Fructus Forsythiae, Semen Sojae Preparatum, decoct with water extraction twice, add the water of 1728kg for the first time, add the water of 1296kg for the second time, decocted 2 hours at every turn, merge extracted twice liquid, filter, get C liquid (2808kg);
(2) get above-mentioned A liquid, be concentrated into 43kg, relative density is 1.30～1.32 (double dilution method surveys), gets extractum;
2, after surplus medicine Flos Lonicerae, Herba Menthae, Herba Schizonepetae, Herba Lophatheri, Fructus Arctii, Radix Platycodonis, Radix Glycyrrhizae powder are broken into coarse powder,, get dry extract with above thick paste mixing, drying;
3, dry extract is ground into fine powder with acetaminophen, sieves, mix, the powder finished product is made in sterilization back packing.Every packed 2g, every 2g contains acetaminophen 360-440mg.
Claims (4)
1, a kind of Chinese medicine and western medicine compound preparation for the treatment of Common Cold is characterized in that described Chinese medicine and western medicine compound preparation has the Chinese medicine and western medicine raw material constituent of following percentage by weight:
Flos Lonicerae 1.51%～28.67, Fructus Forsythiae 1.51%～28.67%, Herba Menthae 0.91%～17.20%, Herba Schizonepetae 0.60%～11.48, Semen Sojae Preparatum 0.75%～14.33%, Fructus Arctii 0.91%～17.20%, Radix Platycodonis 0.91%～17.20%, Herba Lophatheri 0.60%～11.48%, Radix Glycyrrhizae 0.75%～14.33%, acetaminophen 1.55%～29.46%.
2, a kind of Chinese medicine and western medicine compound preparation for the treatment of Common Cold is characterized in that described Chinese medicine and western medicine compound preparation has the Chinese medicine and western medicine raw material constituent of following percentage by weight:
Flos Lonicerae 13.58%～16.60%, Fructus Forsythiae 13.58%～16.60%, Herba Menthae 8.15%～9.96%, Herba Schizonepetae 5.43%～6.64%, Semen Sojae Preparatum 6.79%～8.30%, Fructus Arctii 8.15%～9.96%, Radix Platycodonis 8.15%～9.96%, Herba Lophatheri 5.44%～6.64%, Radix Glycyrrhizae 6.79%～8.29%, acetaminophen 13.96%～17.06%.
3, a kind of preparation method of Chinese medicine and western medicine compound preparation of treatment Common Cold as claimed in claim 1 or 2 is characterized in that this method comprises the following steps:
(1) extracts
(1) extracting honeysuckle is put in the extractor, by weight/volume ratio, add the water of 8 times of amounts the first time, add the water of 6 times of amounts for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, extracted twice liquid is merged, centrifugal filtration gets A liquid;
(2) get Herba Schizonepetae, Herba Menthae, put in the extractor respectively, by weight/volume ratio, the water that adds 2 times of amounts is moistening, adopt steam distillation to distill, collect the oil slick on the distillate, get Herba Schizonepetae oil, Oleum menthae respectively, two kinds of volatile oil are put airtight preservation in the glass container respectively, two kinds of medicinal residues merged decoct 2 times, by weight/volume ratio, add for the first time 8 times of amounts water, add the water of 6 times of amounts for the second time, decoct twice, decocted 1.5 hours for the first time, decocted 1 hour for the second time, merge extracted twice liquid, centrifugal filtration gets B liquid;
(3) get 3.5% Radix Platycodonis of Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Fructus Arctii, formula ratio, decoct with water and extract twice, by weight/volume ratio, add the water of 8 times of amounts for the first time, add the water of 6 times of amounts for the second time, decocted 2 hours at every turn, merge extracted twice liquid, filter, C liquid;
(4) get Semen Sojae Preparatum and put in the extractor, by weight/volume ratio, add the water of 8 times of amounts the first time, add the water of 6 times of amounts for the second time, in 70～80 ℃ of warm macerating twice, each 2 hours, merge extracted twice liquid, filter, boiled 40 minutes in normal pressure, get D liquid;
(5) get above-mentioned A, B, C, the merging of D liquid, be concentrated into 2.2% of original volume, it is 1.20～1.26 that double dilution method is surveyed its relative density, promptly gets extractum;
(2) pulverize, sterilize
Get the Radix platycodi formula amount 97%, acetaminophen, add by medicine and pulverize the sucrose of total amount 14% and 2% Paris white is broken into fine powder, cross 100 mesh sieves, put in the mixer behind the mix homogeneously, pack in the clean cloth bag, use ethylene oxide sterilizing, fine powder;
(3) preparation granule, tabletting
Get sterilization back fine powder and put in the granulator, other gets step (5) extractum and adds as binding agent in 10: 1 ratio dilute with waters, puts in the granulator and mixes, do timing by amount of the mixture, add 1% magnesium stearate, spray into 0.05% Herba Schizonepetae oil and 0.05% Oleum menthae, the preparation granule, tabletting;
(4) make preparation
The granule and the pharmaceutic adjuvant of step (three) are made preparation.
4, according to the described a kind of Chinese medicine and western medicine compound preparation for the treatment of Common Cold of claim 1, it is characterized in that described Chinese medicine and western medicine compound preparation is oral tablet, capsule, powder, granule or oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100359678A CN101249223A (en) | 2008-04-11 | 2008-04-11 | Chinese native medicine and western medicine compound preparations for curing coryza cold |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100359678A CN101249223A (en) | 2008-04-11 | 2008-04-11 | Chinese native medicine and western medicine compound preparations for curing coryza cold |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647547B (en) * | 2009-08-25 | 2012-08-29 | 张勇 | Burdock cooked with fermented soy beans |
| CN104083537A (en) * | 2014-06-20 | 2014-10-08 | 叶耀良 | Chinese and western medicine compound preparation for treating cold and preparing method thereof |
| CN106421257A (en) * | 2016-11-08 | 2017-02-22 | 漯河医学高等专科学校 | Chinese and western medicinal particles for treating cold and preparation method of Chinese and western medicinal particles |
| CN113350299A (en) * | 2021-06-28 | 2021-09-07 | 叶洪艳 | Slow-release medicine suitable for pets and preparation method thereof |
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2008
- 2008-04-11 CN CNA2008100359678A patent/CN101249223A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647547B (en) * | 2009-08-25 | 2012-08-29 | 张勇 | Burdock cooked with fermented soy beans |
| CN104083537A (en) * | 2014-06-20 | 2014-10-08 | 叶耀良 | Chinese and western medicine compound preparation for treating cold and preparing method thereof |
| CN106421257A (en) * | 2016-11-08 | 2017-02-22 | 漯河医学高等专科学校 | Chinese and western medicinal particles for treating cold and preparation method of Chinese and western medicinal particles |
| CN106421257B (en) * | 2016-11-08 | 2017-06-16 | 漯河医学高等专科学校 | It is a kind of to treat Chinese and Western medicine particle of flu and preparation method thereof |
| CN113350299A (en) * | 2021-06-28 | 2021-09-07 | 叶洪艳 | Slow-release medicine suitable for pets and preparation method thereof |
| CN113350299B (en) * | 2021-06-28 | 2022-09-06 | 陕西映诺嘉生物科技有限公司 | Slow-release medicine suitable for pets and preparation method thereof |
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Open date: 20080827 |