CN110638909B - Traditional Chinese medicine composition for improving Jichuan decoction and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for improving Jichuan decoction and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving Jichuan decoction, a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 5-20 parts of prepared fleece-flower root, 2-10 parts of peach kernel, 2-10 parts of Chinese date, 2-10 parts of bunge cherry seed, 2-10 parts of rhizoma alismatis, 2-10 parts of fructus aurantii and 2-10 parts of rhizoma cimicifugae, and the medicaments are combined to play the effects of tonifying kidney and benefiting liver, promoting blood circulation to remove blood stasis, nourishing blood and moistening intestines and relaxing bowel. Has obvious curative effect on intractable constipation, has total effective rate of 97.2 percent after 2 courses of treatment, can obviously relieve clinical symptoms, and has less medicinal ingredients, quick response, no adverse reaction and low recurrence rate.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for improving Jichuan decoction, and a preparation method and application thereof.
Background
Constipation is a common clinical symptom, manifested by dry stools, difficulty in defecation, and reduction in stool weight and frequency. With the aging of society, the change of modern life rhythm and eating habits, the change of disease spectrum and other influences on diseases, constipation becomes one of important factors influencing the life quality of modern people and is closely related to the onset of colorectal cancer. Constipation is caused by various causes such as neurogenic and systemic diseases, and is called secondary constipation. For example, constipation does not have an organic lesion causing constipation, which is called functional constipation, and it has been considered that simple constipation, habitual constipation, idiopathic constipation, and the like. The use of purgative bowel disease and colonic melanosis in constipation sufferers has attracted considerable attention because colonic melanosis is associated with colon cancer and the treatment of functional constipation is therefore becoming more and more important. Constipation includes general constipation and intractable constipation. Among them, intractable constipation is often found in the elderly, which means chronic and chronic functional constipation. However, there are also students who consider that habitual constipation is not limited to functional constipation. It also includes colonic constipation and rectal constipation. Therefore, the elderly suffering from habitual constipation should seek medical advice and find out the cause of the constipation at an early stage. In general, intractable constipation has the following characteristics: intractable constipation is a disease that gradually causes difficulty in defecation at different ages due to anatomical variation of the congenital node and rectum. Intractable constipation can not be treated by non-operative treatment, and also can not be cured by drug treatment. Intractable constipation is not functional but has obvious organic lesion of colon and rectum, and has the problems of great treatment difficulty and easy relapse. Therefore, there is a need for a drug having an effective therapeutic effect on intractable constipation.
Chinese patent document CN105617284A discloses a pharmaceutical composition for treating habitual intractable constipation, wherein the active ingredients of the traditional Chinese medicine are prepared from the following raw materials by weight: 40 parts of cistanche, 40 parts of rhizoma acori graminei, 40 parts of semen cassiae, 35 parts of dandelion, 35 parts of almond, 35 parts of rhizoma alismatis, 35 parts of mulberry, 30 parts of radix curcumae, 30 parts of trichosanthes kirilowii maxim, 30 parts of immature bitter orange, 28 parts of inula flower root, 28 parts of burdock, 28 parts of cortex phellodendri, 25 parts of rhizoma atractylodis macrocephalae, 25 parts of angelica, 25 parts of pericarpium citri reticulatae, 20 parts of polygala tenuifolia, 20 parts of myrrh, 20 parts of ligusticum wallichii, 20 parts of poria cocos, 15 parts of liquorice, 10 parts of Chinese yam and 10 parts of peach kernel; clinical verification shows that the traditional Chinese medicine composition can be used for treating intractable constipation, but has the defects of slow response, low cure rate, high recurrence rate, large medicine dosage, various medicine varieties, high cost and the like.
Disclosure of Invention
Therefore, the invention aims to provide a traditional Chinese medicine composition, a preparation method and application thereof, which can effectively treat intractable constipation.
The invention provides a traditional Chinese medicine composition which comprises the following raw material medicines in parts by weight: 5-20 parts of prepared fleece-flower root, 2-10 parts of peach kernel, 2-10 parts of Chinese date, 2-10 parts of bunge cherry seed, 2-10 parts of rhizoma alismatis, 2-10 parts of fructus aurantii and 2-10 parts of cimicifugae foetidae.
The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 20 parts of prepared fleece-flower root, 10 parts of peach kernel, 10 parts of Chinese date, 10 parts of bunge cherry seed, 10 parts of oriental waterplantain rhizome, 10 parts of bitter orange and 10 parts of cimicifuga foetida.
The traditional Chinese medicine composition is added with conventional auxiliary materials according to a conventional process to prepare a clinically acceptable pharmaceutical preparation.
The invention also provides a medicinal preparation prepared by adding conventional auxiliary materials into any one of the traditional Chinese medicine compositions according to a conventional process.
The medicinal preparation comprises decoction, tablets, granules, capsules, pills and solutions.
The invention also provides a method for preparing any one of the traditional Chinese medicine compositions, which comprises the following steps:
(a) respectively crushing prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to the selected weight parts, and then mixing or mixing and crushing to obtain medicinal powder;
(b) and adding conventional adjuvants into the above medicinal powder, and making into clinically acceptable decoction, tablet, granule, capsule, pill or solution by conventional method.
The invention also provides a method for preparing any one of the traditional Chinese medicine compositions, which comprises the following steps:
(a) respectively crushing prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to the selected weight parts, and then mixing or mixing and crushing to obtain medicinal powder;
(b) soaking the medicinal powder in 50-95vt% ethanol, and percolating with 50-95vt% ethanol as solvent to obtain percolate;
(c) taking the percolate of the traditional Chinese medicine composition, adding conventional auxiliary materials, and preparing into clinically acceptable decoction, tablets, granules, capsules, pills or solutions according to a conventional process.
Further, the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing semen Persicae, fructus Jujubae, Alismatis rhizoma, fructus Aurantii, and cimicifugae rhizoma, adding 8-12 times of water, leaching for 2-10 hr, extracting for 5-15 hr by steam distillation, and collecting volatile oil and water extractive solution;
(2) weighing radix Polygoni Multiflori Preparata and semen Pruni, adding water 8-12 times of the total weight of the medicinal materials, and leaching for 0.5-2 hr to obtain water extractive solution;
(3) mixing the water extractive solutions, precipitating with 50-95vt% ethanol for 8-10 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with relative density of 1.20-1.40, and drying to obtain extract powder;
(4) and (2) adding cyclodextrin which is 6 times of the weight of the volatile oil into the volatile oil prepared in the step (1), grinding and clathrating for 20-40min to prepare a clathrate compound, adding the extract powder prepared in the step (3), uniformly mixing to prepare a medicinal active ingredient, adding conventional auxiliary materials, and preparing a clinically acceptable decoction, tablet, granule, capsule, pill or solution according to a conventional process.
The invention also provides a traditional Chinese medicine composition, a pharmaceutical preparation and an application of the traditional Chinese medicine composition prepared by the method in preparation of a medicine for treating constipation.
Further, the traditional Chinese medicine composition is applied to preparation of a medicine for treating intractable constipation.
The technical scheme of the invention has the following advantages:
the traditional Chinese medicine composition provided by the invention is improved on the basis of the traditional prescription of Jichuan decoction, wherein prepared fleece-flower root in the prescription has the effects of tonifying kidney and liver, moistening intestines and relaxing bowels, peach kernel has the effects of promoting blood circulation and removing meridian obstruction, and breaking blood and removing stasis, and is a monarch drug; the Chinese dates tonify middle-jiao and Qi, nourish blood and tranquilize mind, the bunge cherry seeds have the functions of relaxing bowel, descending qi and promoting diuresis; is used as a ministerial drug; rhizoma alismatis promotes diuresis, excretes dampness, dissolves turbidity and reduces lipid as adjuvant drugs, fructus aurantii regulates qi, relieves epigastric distention, moves stagnancy and relieves distension, rhizoma cimicifugae gives out exterior and promotes eruption, and heat-clearing and detoxifying as messenger drugs; the medicines are combined to play the effects of tonifying the kidney and benefiting the liver, activating blood circulation to dissipate blood stasis, regulating qi and promoting diuresis, nourishing blood and moistening intestines, and relaxing bowel. Has obvious curative effect on intractable constipation, has total effective rate of 91.50-97.2% after 2 courses of treatment, can obviously relieve clinical symptoms, and has the advantages of less medicinal ingredients, quick response, no adverse reaction and low recurrence rate.
Detailed Description
Example 1
10g of prepared fleece-flower root, 5g of peach kernel, 4g of Chinese date, 6g of bunge cherry seed, 3g of rhizoma alismatis, 3g of fructus aurantii and 3g of cimicifugae foetidae.
The preparation method comprises the following steps: (a) respectively crushing prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to the selected weight parts, and then mixing or mixing and crushing to obtain medicinal powder;
(b) soaking the above medicinal powder in 50 vt% ethanol, and percolating with 75 vt% ethanol to obtain percolate;
(c) taking the percolate of the traditional Chinese medicine composition, adding conventional auxiliary materials, and preparing into clinically acceptable tablets according to a conventional process.
Example 2
20g of prepared fleece-flower root, 10g of peach kernel, 10g of Chinese date, 10g of bunge cherry seed, 10g of rhizoma alismatis, 10g of fructus aurantii and 10g of rhizoma cimicifugae.
The preparation method comprises the following steps: (a) respectively crushing prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to the selected weight parts, and then mixing or mixing and crushing to obtain medicinal powder;
(b) and adding conventional adjuvants into the above medicinal powder, and making into clinically acceptable granule by conventional method.
Example 3
15g of prepared fleece-flower root, 10g of peach kernel, 8g of Chinese date, 8g of bunge cherry seed, 3g of rhizoma alismatis, 2g of fructus aurantii and 10g of rhizoma cimicifugae.
The preparation method comprises the following steps: (a) taking prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to selected weight parts, adding purified water, decocting for 2 times, each time for 2 hours, combining decoction, filtering by using 200-mesh silk cloth, filtering filtrate by using a ceramic microfiltration membrane, wherein the filtration pressure difference is 0.18MPa, the membrane surface flow rate is 6000L/hour, and taking the filtrate as a micro-filtrate;
(b) concentrating the micro-filtrate under reduced pressure to obtain soft extract with relative density of 1.20(80 deg.C), and cooling. Adding appropriate amount of sodium carboxymethylcellulose, mixing with the soft extract, adding 0.8% sucralose, granulating, and drying.
Example 4
15g of prepared fleece-flower root, 10g of peach kernel, 8g of Chinese date, 8g of bunge cherry seed, 3g of rhizoma alismatis, 2g of fructus aurantii and 10g of rhizoma cimicifugae.
The preparation method comprises the following steps: (1) weighing semen Persicae, fructus Jujubae, Alismatis rhizoma, fructus Aurantii, and cimicifugae rhizoma, adding 10 times of water, leaching for 5 hr, extracting for 15 hr by steam distillation, and collecting volatile oil and water extractive solution;
(2) weighing prepared polygonum multiflorum and bunge cherry seed, adding water with the weight being 8 times of the total weight of the medicinal materials, and leaching for 2 hours to obtain water extract;
(3) mixing the water extractive solutions, precipitating with 50 vt% ethanol for 10 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with relative density of 1.30(80 deg.C), and drying to obtain extract powder;
(4) and (2) adding cyclodextrin 6 times the weight of the volatile oil into the volatile oil prepared in the step (1), grinding and clathrating for 30min to prepare a clathrate compound, adding the extract powder prepared in the step (3), uniformly mixing to prepare a medicinal active ingredient, adding a proper amount of sodium carboxymethylcellulose, and preparing into clinically acceptable granules according to a conventional process.
Example 5
20g of prepared fleece-flower root, 5g of peach kernel, 5g of Chinese date, 2g of bunge cherry seed, 2g of rhizoma alismatis, 2g of fructus aurantii and 10g of rhizoma cimicifugae.
The preparation method comprises the following steps: (1) weighing semen Persicae, fructus Jujubae, Alismatis rhizoma, fructus Aurantii, and cimicifugae rhizoma, adding 8 times of water, leaching for 10 hr, extracting for 5 hr by steam distillation, and collecting volatile oil and water extractive solution;
(2) weighing prepared fleece-flower root and bunge cherry seed, adding water with the weight being 12 times of the total weight of the medicinal materials, and leaching for 0.5h to obtain water extract;
(3) mixing the water extractive solutions, precipitating with 75 vt% ethanol for 9 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with relative density of 1.20(40 deg.C), and drying to obtain extract powder;
(4) and (2) adding cyclodextrin 6 times the weight of the volatile oil into the volatile oil prepared in the step (1), grinding and clathrating for 40min to prepare a clathrate compound, adding the extract powder prepared in the step (3), uniformly mixing to prepare a medicinal active ingredient, adding conventional auxiliary materials, and preparing a clinically acceptable tablet according to a conventional process.
Example 6
20g of prepared fleece-flower root, 2g of peach kernel, 10g of Chinese date, 2g of bunge cherry seed, 2g of rhizoma alismatis, 2g of fructus aurantii and 10g of rhizoma cimicifugae.
The preparation method comprises the following steps: (1) weighing semen Persicae, fructus Jujubae, Alismatis rhizoma, fructus Aurantii, and cimicifugae rhizoma, adding water 12 times the total weight of the medicinal materials, leaching for 10h, extracting for 5h by steam distillation, and collecting volatile oil and water extractive solution;
(2) weighing prepared polygonum multiflorum and bunge cherry seed, adding water with the weight being 12 times of the total weight of the medicinal materials, and leaching for 2 hours to obtain water extract;
(3) mixing the water extractive solutions, precipitating with 95vt% ethanol for 8 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with relative density of 1.40(80 deg.C), and drying to obtain extract powder;
(4) and (2) adding cyclodextrin 6 times the weight of the volatile oil into the volatile oil prepared in the step (1), grinding and clathrating for 20min to prepare a clathrate, adding the extract powder prepared in the step (3), uniformly mixing to prepare a medicinal active ingredient, adding conventional auxiliary materials, and preparing a clinically acceptable capsule according to a conventional process.
Example 7
15g of prepared fleece-flower root, 5g of peach kernel, 2g of Chinese date, 5g of bunge cherry seed, 5g of rhizoma alismatis, 5g of fructus aurantii and 2g of rhizoma cimicifugae.
The preparation method comprises the following steps: (1) weighing semen Persicae, fructus Jujubae, Alismatis rhizoma, fructus Aurantii, and cimicifugae rhizoma, adding 8 times of water, leaching for 5 hr, extracting for 5 hr by steam distillation, and collecting volatile oil and water extractive solution;
(2) weighing prepared fleece-flower root and bunge cherry seed, adding water with the weight being 12 times of the total weight of the medicinal materials, and leaching for 1 hour to obtain water extract;
(3) mixing the water extractive solutions, precipitating with 50 vt% ethanol for 10 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with relative density of 1.25(80 deg.C), and drying to obtain extract powder;
(4) and (2) adding cyclodextrin 6 times the weight of the volatile oil into the volatile oil prepared in the step (1), grinding and clathrating for 40min to prepare a clathrate compound, adding the extract powder prepared in the step (3), uniformly mixing to prepare a medicinal active ingredient, adding conventional auxiliary materials, and preparing a clinically acceptable solution according to a conventional process.
Example 8
20g of prepared fleece-flower root, 10g of peach kernel, 10g of Chinese date, 10g of bunge cherry seed, 10g of rhizoma alismatis, 10g of fructus aurantii and 10g of rhizoma cimicifugae.
The preparation method comprises the following steps: (a) taking prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to selected weight parts, adding purified water, decocting for 2 times, each time for 2 hours, combining decoction, filtering by using 200-mesh silk cloth, filtering filtrate by using a ceramic microfiltration membrane, wherein the filtration pressure difference is 0.18MPa, the membrane surface flow rate is 6000L/hour, and taking the filtrate as a micro-filtrate;
(b) concentrating the micro-filtrate under reduced pressure to obtain soft extract with relative density of 1.22(80 deg.C), and cooling. Adding appropriate amount of sodium carboxymethylcellulose, mixing with the soft extract, adding 0.8% sucralose, granulating, and drying.
Clinical observations
1. Clinical cases
1.1 clinical data: clinical observations were made on 70 patients with obstipation diagnosed in Hospital, which were randomly divided into 2 groups, experiment 1 group and experiment 2 group. 35 cases in experiment 1 group with age between 20 and 65 years, 35 cases in experiment 2 group with age between 20 and 65 years have no significant difference compared with general data of two groups of cases.
1.2 diagnostic criteria: reference to roman standard II execution within the last 12 months, at least 12 weeks (not necessarily continuously) have two or more of the following events occurred: (1) defecation is urgent; (2) dry or hard; (3) the sense of inexhaustible defecation is achieved; (4) the defecation has the anus obstruction or obstruction feeling; (5) when defecation occurs, extra help is needed, such as finger digging and basin massage; (6) defecation <3 times per week, no observation of loose stools, and insufficient diagnosis of Irritable Bowel Syndrome (IBS).
1.3 evaluation criteria for clinical therapeutic effect were: the method is implemented according to the standard of constipation curative effect judgment in the guideline of clinical research of new traditional Chinese medicines. Clinical cure: the stool is normal, or the level before the disease is recovered, other symptoms disappear completely, and other symptoms disappear completely. The effect is shown: the constipation is obviously improved, the defecation interval time and the stool quality are close to normal, or the stool is slightly dry and the defecation interval time is less than 72 hours, and other symptoms are completely disappeared. The method has the following advantages: the defecation interval is shortened by 1 day, or the feces quality is dried and improved, and other symptoms are all improved. And (4) invalidation: constipation and other symptoms are not improved, the cure rate is the number of cure cases/total cases, the effective rate is the number of effective cases/total cases, and the total effective rate is the cure rate + the effective rate.
1.4 administration method: the drug granules prepared in example 3 and example 4 are orally administered to experiment 1 group and experiment 2 group respectively, one dose is taken every day, one treatment course is taken every 10 days, and wine, spicy hot, thick and greasy food and irritant food are not eaten during the treatment period, so that a bicycle is not ridden for a long time.
2. Therapeutic results
After 2 courses of treatment, the traditional Chinese medicine composition granules prepared in the embodiment 3 and the embodiment 4 of the invention are orally taken to treat 70 patients, wherein in the experiment 1 group, 29 patients are cured and account for 82.9%, 2 patients with obvious effect and 5.7%, 1 patient with effective effect and 2.9%, the total effective rate is 91.5%, in the experiment 2 group, 32 patients are cured and account for 91.4%, 1 patient with obvious effect and 2.9%, 1 patient with effective effect and 2.9%, and the total effective rate is 97.2%; experiment 2 is significantly better than experiment 1, and no obvious adverse drug reactions occur in the treatment period of the two groups of patients.
3 conclusion
(1) The traditional Chinese medicine composition has a remarkable treatment effect on the aspect of treating intractable constipation, the total effective rate can reach 97.2 percent in 2 treatment courses, the treatment course is short, the effect is quick, the recurrence rate is low, and no toxic or side effect exists.
Examples of typical cases are:
wangzhi, male, 49 years old, will see the doctor 11 months in 2013. The patient has symptoms of hard stool and difficult excretion for nearly 4 years. Dry stool, no obvious tenderness in the abdominal cavity, occasional abdominal pain, frequent defecation with intention but difficult excretion, defecation 1 time every 4-5 days, tongue full of white fur, and deep and thready pulse. The granules of the embodiment 3 of the invention are orally taken, one dose is taken every day, the medicine is taken for 3 days, the patient defecates one row every day, all symptoms are relieved, the treatment is continued for 7 days, all symptoms disappear, and the disease does not relapse after half-year follow-up.
Thanks to someone, women, 42 years old, visit 6 in 2012. The patient has a 9-year constipation history, obvious constipation occurs, the patient is discharged every 6-7 days, the anus is blocked or blocked when the patient defecates, the patient does not defecate easily, the abdominal cavity is full of the abdominal cavity, the patient feels pain when pressing the abdominal cavity, the tongue is full of white fur, and the pulse is smooth and solid. The granules of the embodiment 4 of the invention are orally taken, one dose is taken every day, the medicine is taken for 3 days, the patient defecates one row every day, all symptoms are relieved, the treatment is continued for 7 days, the symptoms are obviously improved, the treatment is continued for 5 days, the symptoms disappear, and the half-year follow-up does not relapse.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (10)
1. The traditional Chinese medicine composition is characterized by comprising the following raw material medicines in parts by weight: 5-20 parts of prepared fleece-flower root, 2-10 parts of peach kernel, 2-10 parts of Chinese date, 2-10 parts of bunge cherry seed, 2-10 parts of rhizoma alismatis, 2-10 parts of fructus aurantii and 2-10 parts of cimicifugae foetidae.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 10 parts of prepared fleece-flower root, 5 parts of peach kernel, 4 parts of Chinese date, 6 parts of bunge cherry seed, 3 parts of oriental waterplantain rhizome, 3 parts of bitter orange and 3 parts of cimicifuga foetida.
3. The traditional Chinese medicine composition according to claim 1 or 2, wherein the traditional Chinese medicine composition is prepared into a clinically acceptable pharmaceutical preparation by adding conventional auxiliary materials according to a conventional process.
4. The traditional Chinese medicine composition of any one of claims 1 to 3 is added with conventional auxiliary materials to prepare the prepared medicinal preparation according to a conventional process.
5. The pharmaceutical formulation of claim 4, wherein the pharmaceutical formulation comprises a decoction, a tablet, a granule, a capsule, a pill, a solution.
6. A method of preparing a Chinese medicinal composition as claimed in any one of claims 1 to 3, comprising the steps of:
(a) respectively crushing prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to the selected weight parts, and then mixing or mixing and crushing to obtain medicinal powder;
(b) and adding conventional adjuvants into the above medicinal powder, and making into clinically acceptable decoction, tablet, granule, capsule, pill or solution by conventional method.
7. A method of preparing a Chinese medicinal composition as claimed in any one of claims 1 to 3, comprising the steps of:
(a) respectively crushing prepared fleece-flower root, peach kernel, Chinese date, bunge cherry seed, rhizoma alismatis, fructus aurantii and rhizoma cimicifugae according to the selected weight parts, and then mixing or mixing and crushing to obtain medicinal powder;
(b) soaking the medicinal powder in 50-95vt% ethanol, and percolating with 50-95vt% ethanol as solvent to obtain percolate;
(c) taking the percolate of the traditional Chinese medicine composition, adding conventional auxiliary materials, and preparing into clinically acceptable decoction, tablets, granules, capsules, pills or solutions according to a conventional process.
8. A method of preparing a Chinese medicinal composition as claimed in any one of claims 1 to 3, comprising the steps of:
(1) weighing semen Persicae, fructus Jujubae, Alismatis rhizoma, fructus Aurantii, and cimicifugae rhizoma, adding 8-12 times of water, leaching for 2-10 hr, extracting for 5-15 hr by steam distillation, and collecting volatile oil and water extractive solution;
(2) weighing radix Polygoni Multiflori Preparata and semen Pruni, adding water 8-12 times of the total weight of the medicinal materials, and leaching for 0.5-2 hr to obtain water extractive solution;
(3) mixing the water extractive solutions, precipitating with 50-95vt% ethanol for 8-10 hr, collecting supernatant, concentrating under reduced pressure to obtain extract with relative density of 1.20-1.40, and drying to obtain extract powder;
(4) and (2) adding cyclodextrin which is 5-6 times of the weight of the volatile oil into the volatile oil prepared in the step (1), grinding and clathrating for 20-40min to prepare an inclusion compound, adding the extract powder prepared in the step (3), uniformly mixing to prepare a medicinal active ingredient, adding conventional auxiliary materials, and preparing a clinically acceptable decoction, tablet, granule, capsule, pill or solution according to a conventional process.
9. Use of a Chinese medicinal composition according to any one of claims 1 to 3, a pharmaceutical formulation according to claim 4 or 5, or a Chinese medicinal composition prepared by a method according to any one of claims 6 to 8 in the preparation of a medicament for the treatment of constipation.
10. The use of claim 9, wherein the use of the composition is for the preparation of a medicament for the treatment of intractable constipation.
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| CN1813961A (en) * | 2005-11-17 | 2006-08-09 | 神威药业有限公司 | Medicinal composition for treating astriction |
| CN101181470A (en) * | 2007-11-28 | 2008-05-21 | 荣玉明 | Chinese medicine prescription for constipation as well as preparation method thereof |
| CN102114108A (en) * | 2010-09-20 | 2011-07-06 | 孔祥军 | Chinese medicinal composition for treating constipation |
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| CN1813961A (en) * | 2005-11-17 | 2006-08-09 | 神威药业有限公司 | Medicinal composition for treating astriction |
| CN101181470A (en) * | 2007-11-28 | 2008-05-21 | 荣玉明 | Chinese medicine prescription for constipation as well as preparation method thereof |
| CN102114108A (en) * | 2010-09-20 | 2011-07-06 | 孔祥军 | Chinese medicinal composition for treating constipation |
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