CN100473391C - Novel use of Cynoglossum - Google Patents
Novel use of Cynoglossum Download PDFInfo
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- CN100473391C CN100473391C CNB2006100215969A CN200610021596A CN100473391C CN 100473391 C CN100473391 C CN 100473391C CN B2006100215969 A CNB2006100215969 A CN B2006100215969A CN 200610021596 A CN200610021596 A CN 200610021596A CN 100473391 C CN100473391 C CN 100473391C
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Abstract
The invention relates to the novel use of cynoglossum zeylanicum, more specifically, to the use of cynoglossum zeylanicum and its extract in preparing medicament for treating prostate gland diseases and sexual disorder caused by prostate gland diseases.
Description
Technical field
The present invention relates to the new purposes of Fructus Lithospermi Zollingeri, specifically, is the purposes that is used for preparing the medicine of the sexual dysfunction that reasons such as treatment prostatosis and prostatosis cause.
Background technology
Prostatosis is a kind of commonly encountered diseases, the frequently-occurring disease that between twenty and fifty particularly middle-aging male is easily suffered from.It is reported among the male about 30 years old, suffer from accounting for more than 30% of prostatosis, and male more than 50 years old to suffer from accounting for about 56% of prostatosis, prostatosis becomes " male's first disease ", and the trend that enlarges and become younger is arranged in recent years.
Prostatosis also claims the trouble of male's lower abdomen, mainly contains: inflammation, hypertrophy, prostate tumor, hypertrophy and cancer.Prostatitis is the commonly encountered diseases of male adults, accounts for Urology Surgery adult male patient's 25%-40%.The prostate hyperplasia that the male all had later in various degree in 55 years old, due to illness journey is slow, and early symptom is not obvious, is difficult for being much accounted of.Benign prostatic hyperplasia (BPH) is a modal disease in the elderly men, also is modal benign tumor among the male.BPH is often relevant with a series of irritations and lower urinary tract symptom (LUTS), and patient's life is brought negative effect; And untreated BPH can cause modal in the complication acute urinary retention (AUR), gross hematuria, repeatability urinary tract infection, urinary tract obstruction symptom, sexual dysfunction, vesical calculus etc. being arranged, and more rare have a renal failure.
Prostatic hyperplasia and prostatitic symptom mainly show as: urgent micturition, frequent micturition, dysurea, urine retention, the heeltap, dampness of scrotum, lower abdomen are suppressed bloated, severe patient can have hematuria, it is white to drip, lower abdomen is suppressed pain, and symptoms such as fever, soreness of the waist and knees, headache and dizziness, spiritlessness and weakness.Prostatic hyperplasia and prostatitis patient are many with sexual dysfunction, mainly show as: hyposexuality, unable, the premature ejaculation of jerking, sexual intercourse reflex pain etc.
Treatment to prostatic hyperplasia, generally based on Drug therapy and operative treatment, the purpose that the medicine smelting is treated is to eliminate symptom, suppresses hypertrophy, but the most drug effect of this class medicine is not good, or serious side effects is arranged, for example hytrin, phenoxybenzamine hydrochloride etc., though the former has certain curative effect, but need take medicine throughout one's life, withdrawal reaction (drug withdrawal slightly, bounce-back immediately) occur; The latter has serious side effects, and most of patient can't take at all on request.In recent years the proscar of Chu Xianing is the medicine that impels prostate to dwindle preferably, but this medicine must be taken medicine more than 6 months at least, and oneself confirms that the side effect of proscar has sexual impotence, hyposexuality, ejaculate volume minimizing etc., and these do one's utmost diseases that will overcome of prostatosis patient just.In addition, the related data report is arranged, leaf of plant medicine such as South Africa this plant of star flowers and plants Herba Urticae Cannabinae and root etc. prostatic hyperplasia is had certain curative effect, but its mechanism of action are still indeterminate, and curative effect is still to be tested.Operative treatment can effect a radical cure prostatic hyperplasia, but this kind method only is suitable for the serious patient of hypertrophy, there is the patient of the sign that is not suitable for performing the operation inapplicable to general patient and old the grade, and the surgery cost costliness, and might cause sequela such as sexual dysfunction, urinary incontinence.
Treatment to chronic prostatitis has multiple therapy methods, as acupuncture-moxibustion, massage, demibain, physiotherapy etc., but based on Drug therapy, by Drug therapy to reach symptomatolytic purpose.Though chronic prostatitis is divided into chronic bacterial prostatitis and chronic nonbacterial prostatitis, but because the two symptom, sign are close, cause of disease complexity (for example also can turn out bacterial pathogen) at chronic nonbacterial prostatitis, therefore be difficult to the two strictness is made a distinction in the medical practice, (for example SMZCo, TMP etc. must keep more than 12 weeks of medication the heavy dose of antibiotics of general employing in treatment; 100 milligrams of 2 (300 milligrams)+trimethoprim (TMP)s of rifampicin, 4 months courses of treatment of standard etc.) and symptomatic treatment, but because prostate has the tough and tensile peplos of one deck, medicine is difficult to pass peplos and reaches focus, and prostate and anus, urethra etc. are adjacent in addition, infect mutually, influence each other, cause state of an illness obstinate, delay repeatedly, the patient not only will bear expensive medical expense, also will bear secular ailing the torment.So Chinese Chinese medicine academy classifies prostatic hyperplasia and chronic prostatitis one of as 128 kinds of difficult and complicated illness.
Fructus Lithospermi Zollingeri is Lindelofia stylosa as one borage family plant Fructus Lithospermi Zollingeri Cynoglos-sum zeylanicum (Vahl) Thunb.exLehm., is used as medicine with root, leaf, among the people be commonly called as paste that bone looses, Radix Clematidis Clarkeanae, sticking stickweed, sticking goddess, pigtail, big Fructus Lithospermi Zollingeri.The little hardship of Fructus Lithospermi Zollingeri, cold; Clearing away heat-damp and promoting diuresis, promoting blood flow to regulate menstruation.Cure mainly hepatitis, menoxenia, leucorrhea, edema.External is usually used in treating furuncle carbuncle, venom, traumatic injury, fracture.
Still have nothing to do in separately being the relevant report that raw material or the pharmaceutical composition that contains Fructus Lithospermi Zollingeri are applied to treat the sexual dysfunction that reasons such as prostatosis and prostatosis cause with the Fructus Lithospermi Zollingeri.
Summary of the invention
Technical problem to be solved by this invention has provided the new purposes of Fructus Lithospermi Zollingeri.The present invention also provides a kind of pharmaceutical composition for the treatment of the sexual dysfunction that reasons such as prostatosis and prostatosis cause.
The invention provides the new purposes of Fructus Lithospermi Zollingeri, particularly, is the purposes in the medicine of the sexual dysfunction that reasons such as preparation treatment prostatosis and prostatosis cause.
Fructus Lithospermi Zollingeri is the herb of Lindelofia stylosa as one borage family plant Fructus Lithospermi Zollingeri Cynoglos-sum zeylanicum (Vahl) Thunb.exLehm.Can use its primary crude drug or extract.
Wherein, described medicine is treatment prostatic hyperplasia, prostatitis, comprises the medicine of the sexual dysfunction that reason such as prostatosis causes.
Described extract is water or extractive with organic solvent.Described organic solvent is meant the solvent of opposed polarities such as ethanol, methanol.
The present invention also provides a kind of pharmaceutical composition for the treatment of prostatosis, and it is to be active component with the Fructus Lithospermi Zollingeri primary crude drug of effective dose or extract, adds the medicament that acceptable accessories or complementary composition are prepared from.
Medicine of the present invention or pharmaceutical composition, its medicament are oral formulations, external preparation or ejection preparation.
Further, described oral formulations is a decoct, powder, bag bubble electuary (teabag), tablet, tincture, pill, extractum, oral liquid, capsule or granule; Described external preparation is ointment, suppository.
Containing the Fructus Lithospermi Zollingeri primary crude drug in the described medicament in every preparation unit is the 5-30 gram; Water or extractive with organic solvent are the 0.2-2 gram.The unit of being meant of described preparation unit taking dose, as every in tablet, every of capsule, the every 10ml of oral liquid or the like, said preparation unit is the direct reflection of people's taking dose.
The inventor uses Fructus Lithospermi Zollingeri preparation for treating prostatosis of the present invention, after general two courses of treatment of medication (15 days), symptom is clearly better, and four of medications are more than the course of treatment, symptom disappears substantially, it is smooth and easy to urinate, irritations sign of bladder such as no urgent micturition, frequent micturition, dysurea, and also sexual function is restored, it is strong strong to erect, time lengthening does not have soreness of the waist and knees after the sexual life, the sensation of fatigue and weak.Simultaneously, prostatic hyperplasia is suppressed and begins and dwindles, and medication 2-3 month, it is normal that outgrowth prostate progressively recovers.
According to the differential diagnosis in tcm theory, the symptom of prostatosis: urgent micturition, frequent micturition, dysurea, sore waist and aching in the waist and the back, soreness of the waist and knees, fatigue and weak, the night sweat dreaminess, hyposexuality, sexual impotence, premature ejaculation etc. belong to the category of suffering from a deficiency of the kidney, and are because QI and blood is not good, due to essence and blood two loses.The traditional Chinese medical science thinks that kidney is the dirty of water, hides Kidney-Yin and residence Yuanyang, is the source of people's bulk-growth, growth, reproduction, is the root of vital movement, is the congenital foundation." so the wound of the five internal organs must reach kidney thoroughly ".Execute the theory of controlling according to differential diagnosis in tcm, the treatment prostatosis should blood circulation promoting and blood stasis dispelling, and clearing away heat-damp and promoting diuresis removes infirmityization knot, eliminates symptom, and reinforcing kidney and strengthening resistance is again repaired and improved body function, and enhancing human body immunity power reaches the effect for the treatment of both the principal and secondary aspects of a disease.Use Fructus Lithospermi Zollingeri to be used for the treatment of the sexual dysfunction that prostatosis and prostatosis cause, have anti-inflammatory analgetic, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing removes infirmityization knot, the effect of kidney invigorating and YANG supporting; About patient's medication 20 to 30 days, irritation sign of bladder and soreness of the waist and knees such as urgent micturition, frequent micturition, dysurea, symptoms such as fatigue and weak progressively disappear, prostatic hyperplasia is suppressed and begins and dwindles, and patient's spirit and QI cleaning is energetic, and libido strengthens, it is strong strong to erect, and the sexual life time obviously prolongs, and no tired, nervous, the heart tires out after the sexual life.
The sexual dysfunction that Fructus Lithospermi Zollingeri treatment prostatosis and prostatosis etc. cause does not have any toxicity, side effect even take for a long time yet; Can improve and repair some physiological function of human body, improve people's Abwehrkraft des Koepers and quality of life, the sexual dysfunction that causes for clinical treatment prostatosis and prostatosis etc. provides a kind of new selection.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 medicinal tablet of the present invention
Get Fructus Lithospermi Zollingeri dry powder 500 gram, press dose 15 extraordinarily water logging steeped 1 hour, put Decocting pot and endured 1 hour, leach medicinal liquid, add 10 times of decoctings 1 hour again, leach medicinal liquid, merge medicinal liquid twice, dehydration is concentrated into the thick paste shape, adds 15% soluble starch dextrin (or adding isodose 200 order crude drug powder), mixing, 60 ℃ of oven dry are pulverized, add 1% magnesium stearate mixing, cross 20 mesh sieve granulate, tabletting, sheet weigh 0.5 gram (every gram is equivalent to crude drug 5 grams).Instructions of taking: each 2-3 sheet, three times on the one.
The preparation of embodiment 2 medicine bag tea agents of the present invention
Get 1 kilogram of Fructus Lithospermi Zollingeri, Radix Glycyrrhizae 80 grams, the common pulverizing crossed the 60-80 mesh sieve, packs into teabag by every bag of 3-5 gram with filter paper on bag tea machine.Instructions of taking: three bags of every days, early, middle and late each one bag.Medicated bag is put into thermos cup, brew with boiled water and drink after 20-30 minute.This teabag glycol is good to eat, can drink throughout the year, also can drink by dose 1/3 adding Folium Camelliae sinensis or Radix Et Rhizoma Fagopyri Tatarici.
The preparation of embodiment 3 medicine water decoctions of the present invention
Get Fructus Lithospermi Zollingeri dry powder 30 grams, Radix Glycyrrhizae 1-3 gram adds water 10-15 doubly, soaks 1 hour, inserts Decocting pot, fries in shallow oil one hour, pours out medicinal liquid, adds 10 times of water again, fries in shallow oil 30 minutes, merges decocting liquid twice, and early, middle and late branch takes for three times.
The preparation of embodiment 4 medicine capsules of the present invention
Get Fructus Lithospermi Zollingeri dry powder 500 gram, press dose 15 extraordinarily water logging steeped 1 hour, put Decocting pot and endured 1 hour, leach medicinal liquid, add 10 times of decoctings 1 hour again, leach medicinal liquid, merge medicinal liquid twice, dehydration is concentrated into the thick paste shape, add 20%200 order crude drug powder,, pulverize 60 ℃ of dryings.This medicated powder is restrained into capsule (every gram is equivalent to crude drug 5 grams) by every explosive payload 0.4.Instructions of taking: each 2-3 grain, three times on the one.
The preparation of embodiment 5 medicine oral liquids of the present invention
Get Fructus Lithospermi Zollingeri dry powder 500 grams, Radix Glycyrrhizae 10-20 gram, press dose 15 extraordinarily water logging steeped 1 hour, put Decocting pot and endured 1 hour, leach medicinal liquid, add 10 times of decoctings 1 hour again, leach medicinal liquid, merge medicinal liquid twice, dehydration is concentrated into density d=1.2-1.3 (70-80 ℃ of survey), this medicinal liquid is loaded on (every 10ml is equivalent to crude drug 2.5 grams) in the 10ml glass bottle, seals, steam sterilization gets final product.This product does not contain antiseptic, and glycol is good to eat.Usage: oral, one time 1-2 props up, every day three times.
The preparation of embodiment 6 drug compound preparations of the present invention
The prostatitis prescription: Fructus Lithospermi Zollingeri 15 grams, Herba Cistanches 15 grams, Herba Epimedii 15 grams, Radix Glycyrrhizae 10 grams, Radix Rehmanniae Preparata 15 grams, Radix Polygoni Multiflori Preparata 20 grams, Fructus Lycii 15 grams, Rhizoma Dioscoreae 20 grams, Radix Salviae Miltiorrhizae 15 grams, Radix Angelicae Sinensis 15 grams, Cortex Phellodendri 10 grams are decocted in water for oral dose.This prescription also can be made preparations such as tablet, capsule, oral liquid by the method for embodiment 1,4,5.
Wherein Fructus Lithospermi Zollingeri is the monarch drug of prescription, based on Chinese medical theory, under determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, according to different clinical symptoms, is monarch drug with the Fructus Lithospermi Zollingeri, but other Chinese herbal medicine of compatibility, to satisfy clinical different needs.
The preparation of embodiment 7 drug injections of the present invention
Get 2 kilograms in Fructus Lithospermi Zollingeri dry powder, 15 times of adding distil waters boiled 1 hour, filter, residue adds 10 times of decocting in water 1 hour again, filters, merging filtrate is concentrated into the thick paste shape, adds 96% ethanol, make and contain alcohol amount and reach 80%, place after 24 hours, sucking filtration reclaims ethanol, after twice of the repeated precipitation, with filtrate adding distil water to 800 milliliter.Add 1% active carbon, sucking filtration, filtrate adding distil water to 1000 milliliter is heated to 80 ℃, adds 2% benzyl alcohol, and sucking filtration is to clear and bright repeatedly, in 2 milliliters of ampoules of embedding (every milliliter is equivalent to contain crude drug 2 grams), steam sterilization 30 minutes, standby.Intramuscular injection, one day twice, each 2 milliliters.
The preparation of embodiment 8 suppositorys of the present invention
Get Fructus Lithospermi Zollingeri dry powder 150g, add water 10-15 doubly, soaked 1 hour, insert Decocting pot, decoct 1 hour, pour out medicinal liquid, add 10 times of water again, fried in shallow oil 30 minutes, merge decocting liquid twice; Concentrate decocting liquid to dried cream, add Borax 10g, Borneolum Syntheticum 10g, pulverizing, porphyrize; Get S-40 500g and melt in water-bath, the dried cream fine powder of porphyrize is added grind in the above-mentioned substrate evenly, insulation is irritated mould and is got final product.Use one every day.
The preparation of embodiment 9 ointments of the present invention
Get Fructus Lithospermi Zollingeri dry powder 150g, add water 10-15 doubly, soaked 1 hour, insert Decocting pot, decoct 1 hour, pour out medicinal liquid, add 10 times of water again, fried in shallow oil 30 minutes, merge decocting liquid twice; Concentrate decocting liquid to dried cream, add Borax 10g, Borneolum Syntheticum 10g, pulverizing, porphyrize; Taking polyethylene glycol 3350 400g, PEG400 600g mix two kinds of Polyethylene Glycol, are heated to 65 ℃ in water-bath, are stirred to condensation, promptly get substrate; The dried cream fine powder of porphyrize is added in the substrate of condensation, and mix homogeneously gets final product.
Below the beneficial effect of the sexual dysfunction that causes by clinical case statistical confirmation Fructus Lithospermi Zollingeri treatment prostatosis and prostatosis.
Its criterion of therapeutical effect is: symptom complete obiteration, drug withdrawal were not recurred for curing in one month; Symptom disappears substantially, or behind the transference cure in one month recurrence for produce effects.
Treatment chronic prostatitis 16 people, 1 people below 30 years old accounts for 6.25%, and 30-50 year 9 people account for 6 people more than 56.25%, 50 years old, account for 37.5%.To this part patient's treatment, 3 people's intramuscular injection Fructus Lithospermi Zollingeri injection (embodiment 7 preparations) are arranged, every day twice, each one.5-7 days transference cures of 2 people's medications; One people requires after 3 days to change the clothes oral formulations in injection, takes capsule (embodiment 4 preparations) recovery from illness after 9 days.All the other patients adopt decoct (embodiment 3 preparations), capsule (embodiment 4 preparations) or bag tea agent (embodiment 2 preparations), and overcome usefulness by crude drug amount 15-20 every day, and do not wait the 7-30 days course of treatment, and part patient has added bactrim, antibiotic such as doxycycline.Therapeutic outcome: cure 29 people, cure rate 78.38%, produce effects 8 people; Effective percentage 100%..
Treatment prostatic hyperplasia 6 people, the right side of fifty 1 people wherein, 50-70 year 3 people, 2 people more than 70 years old, patient all make a definite diagnosis through ultrasound diagnosis, and medical history 2-5 is surplus in the of the longest existing ten year; The patient passes through various treatments, and wherein 1 people moved operation; Because course of disease delay repeatedly, most of patients is not entertained hope to existing treatment means.Patient's symptom is based on urgent micturition, frequent micturition, dysurea, the heeltap, urine retention, and groups of people have symptoms such as soreness of the waist and knees, spiritlessness and weakness, all with sexual dysfunction.The treatment initial stage is all for oral administration with decoct, and every day, dosage was crude drug 20-30 gram, decocted twice and merged medicinal liquid, and early, middle and late branch takes orally for three times.After taking medicine 20-30 days, all patient's irritations sign of bladder disappear substantially, and sexual function obviously improves; After this change clothes capsule (embodiment 4 preparations) or oral liquid (embodiment 5 preparations), B ultrasonic check after two months, it is normal that 2 human prostates recover, and 3 human prostates dwindle the 0.2-0.5 centimetre, and 1 people dwindles not obvious, effective percentage 100%.
Model case: Wu, 58 years old, certain sugar refinery retired employees.Suffered from prostatic hyperplasia 3 years, ultrasound diagnosis in March, 2006, the prostate size is 4.3 * 3.4cm, successively takes proscar, QIANLIEKANG, ginseng Rong's nine flavor capsules etc.; Readme urgent micturition, frequent micturition, dysurea, urine retention increase the weight of during prescription on individual diagnosis, dysuria, and sensation soreness of the waist and knees, tired asthenia, recent months does not have sexual life substantially.With after Fructus Lithospermi Zollingeri decoct of the present invention (embodiment 3 preparation) treatment January, patient's subjective symptoms disappears, can obtain satisfied sexual life, continue to take capsule of the present invention (embodiment 4 preparations) B ultrasonic check after two months, conclusion is: " filling of bladder; no abnormal in the Guang, prostate size 4 * 3 * 2.6.”
Above-mentioned clinical statistics test is primarily aimed at chronic prostatitis, prostatic hyperplasia, all belong to prostatosis, the various etiology and pathogenesis that directly reflected the morbidity of prostatic lesion position, be enough to summarize all prostatosis, prove absolutely that medicine of the present invention at prostatosis and complication, has tangible drug effect, and owing to belong to crude drug, wide material sources provide a kind of new selection for clinical.
Claims (9)
1, Fructus Lithospermi Zollingeri or its extract purposes in the medicine of the sexual dysfunction that preparation treatment prostatosis or prostatosis cause.
2, purposes according to claim 1 is characterized in that: described prostatosis is a prostatic hyperplasia.
3, purposes according to claim 1 is characterized in that: described prostatosis is a prostatitis.
4, according to each described purposes of claim 1-3, it is characterized in that: Fructus Lithospermi Zollingeri is the herb of Lindelofia stylosa as one borage family plant Fructus Lithospermi Zollingeri.
5, according to each described purposes of claim 1-3, it is characterized in that: described extract is water or extractive with organic solvent.
6, according to each described purposes of claim 1-3, it is characterized in that: described medicine is for being active component by Fructus Lithospermi Zollingeri primary crude drug, processed product or the extract of effective dose, adds pharmaceutically adjuvant or the medicament that is prepared from of complementary composition.
7, purposes according to claim 6 is characterized in that: it is the 5-30 gram that the Fructus Lithospermi Zollingeri primary crude drug is contained in the every preparation unit of described medicament; Water or extractive with organic solvent are the 0.2-2 gram.
8, purposes according to claim 6 is characterized in that: described medicament is oral formulations, external preparation or ejection preparation.
9, purposes according to claim 8 is characterized in that: described oral formulations is decoct, powder, bag bubble electuary, tablet, tincture, pill, extractum, oral liquid, capsule or granule; Described external preparation is ointment or suppository.
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| CNB2006100215969A CN100473391C (en) | 2006-08-11 | 2006-08-11 | Novel use of Cynoglossum |
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| CN101618059B (en) * | 2009-08-07 | 2011-06-29 | 耿福能 | Preparation method and medical application of cynoglossum zeylanicum total phenolic acid |
| CN111991483A (en) * | 2020-08-25 | 2020-11-27 | 钟利永 | Multifunctional health-care medicinal liquor and preparation method thereof |
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| CN1706433A (en) * | 2005-04-21 | 2005-12-14 | 张继成 | Chinese medicine composition for treating gastrointestinal diseases |
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Non-Patent Citations (2)
| Title |
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| 琉璃草水溶性浸出物对小鼠抗炎镇痛作用的研究，. 张国安，刘红，陈佐会.湖北民族学院学报(医学版) ，，第18卷第4期. 2001 |
| 琉璃草水溶性浸出物对小鼠抗炎镇痛作用的研究，张国安，刘红，陈佐会.湖北民族学院学报(医学版) ，第18卷第4期. 2001 * |
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