CN101695555B - Medicament composition for treating prostatitis and prostatomegaly and preparation method thereof - Google Patents
Medicament composition for treating prostatitis and prostatomegaly and preparation method thereof Download PDFInfo
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- CN101695555B CN101695555B CN2008101764996A CN200810176499A CN101695555B CN 101695555 B CN101695555 B CN 101695555B CN 2008101764996 A CN2008101764996 A CN 2008101764996A CN 200810176499 A CN200810176499 A CN 200810176499A CN 101695555 B CN101695555 B CN 101695555B
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Abstract
The invention discloses a medicament composition for treating prostatitis and prostatomegaly and a preparation method thereof. The medicament is mainly prepared by the following raw material medicaments: turtle shell, tortoise shell, Indian iphigenia bulb, ground beeltle, sanguisuga, centipede, pangolin scales, raidx astragali, ginseng, rhizoma corydalis, hiraute shiny bugleweed herb, sanchi, peach seed, common macrocarpium fruit, amber, green tangerine peel, rice bean, fennel fruit, sappan wood, pinellia tuber, south dodder seed, rehmannia glutinosa, thunberg fritillary bulb, wax gourd seed, grassleaf sweelflag rhizome, szechwan chinaberry fruit, common yam rhizome, zedoary, sargentgloryvine stem, white mustard seed, Chinese eaglewood, medicinal cyathula root, szechuan lovage rhizome and dragon's blood. The medicament can be prepared into any preparations suitable to be taken orally or externally in clinic according to the traditional Chinese medicament conventional preparation method. Clinical trial results show that the medicament composition has obvious effects on the prostatitis and the prostatomegaly, and toxic and side effects are not seen in clinical observation.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, relate in particular to a kind of pharmaceutical composition for the treatment of prostatitis, prostatic hyperplasia and preparation method thereof, belong to the treatment field of prostatosis.
Background technology
The prostatitic cause of disease traditional Chinese medical science think primary disease many with the damp and hot fire-toxin of diseases caused by exogenous pathogenic factor, selfish desire is unsuccessful, hyperactivity of the ministerial fire, or wine and women-sensual pursuits overstrain, taste are impaired, damp invasion of lower energizer loses smart the silt and hinders, factors such as phlegm accumulating with stagnant blood are relevant.With the heart, late at night, spleen, internal organs such as kidney are relevant, the clinical blood stasis that shows as more, the expectorant knot, damp and hot, pattern of syndrome such as suffer from a deficiency of the kidney, heavy when light during symptom, not heal repeatedly, patient is very painful, again since the sick position of prostatitis at the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and prostatic lipid envelope is dense, makes general medicine be difficult to penetrate, can not arrive lesion region, prostatitis is not healed for a long time in addition, makes gland leaf fibre hamartoplasia, the prostate catheter drainage is not smooth, makes medicine more be difficult to penetrate, and makes the more touching difficulty of disease more.
Existing be used for the treatment of prostatitic in, Western medicine has a variety ofly, for treatment of diabetes certain curative effect arranged all, but mostly in various degree exist slow, the defective such as curative effect is remarkable inadequately that takes effect, have much room for improvement.
Summary of the invention
The present invention's technical problem at first to be solved is to solve existing slow, the defective such as curative effect is remarkable inadequately that takes effect of the medicine of existing treatment, and a kind of instant effect, the prostatitic pharmaceutical composition of treatment evident in efficacy are provided.
Another technical problem to be solved by this invention provides a kind of method for preparing aforementioned pharmaceutical compositions.
Technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of prostatitis, prostatic hyperplasia comprises that each crude drug of following weight portion is made:
Carapax Trionycis 10-30 part, Carapax Et Plastrum Testudinis 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Squama Manis 0.5-3 part, Radix Astragali 10-20 part, Radix Ginseng 5-15 part, Rhizoma Corydalis 10-20 part, Herba Lycopi 10-20 part, Radix Notoginseng 1-6 part, Semen Persicae 5-12 part, Fructus Corni 9-15 part, succinum 1-6 part, Pericarpium Citri Reticulatae Viride 3-9 part, Semen Phaseoli 9-15 part, Fructus Foeniculi 9-15 part, Lignum Sappan 9-15 part, Rhizoma Pinelliae 5-12 part, Semen Cuscutae 10-20 part, Radix Rehmanniae Preparata 5-15 part, Bulbus Fritillariae Thunbergii 3-9 part, Semen Benincasae 10-20 part, Rhizoma Acori Graminei 9-15 part, Fructus Toosendan 5-15 part, Rhizoma Dioscoreae 9-15 part, Rhizoma Curcumae 5-12 part, Caulis Sargentodoxae 10-20 part, Semen Sinapis Albae 5-15 part, Lignum Aquilariae Resinatum 0.5-2 part, Radix Cyathulae 9-15 part, Rhizoma Chuanxiong 9-15 part and Sanguis Draxonis 1-4 part;
Preferably, the weight portion of each crude drug is: 20 parts of (quench in vinegar) Carapax Trionycis, 15 parts of (quench in vinegar) Carapax Et Plastrum Testudiniss, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, 1.5 parts of Squama Maniss, 15 parts of the Radixs Astragali, 10 parts of Radix Ginsengs, 15 parts of Rhizoma Corydalis, 15 parts of Herba Lycopi, 3 parts of Radix Notoginseng, 8 parts in Semen Persicae, 12 parts of Fructus Corni, 3 parts of succinums, 6 parts on Pericarpium Citri Reticulatae Viride, 12 parts of Semen Phaseolis, 12 parts of Fructus Foeniculi, 12 parts of Lignum Sappans, 8 parts of the Rhizoma Pinelliaes, 15 parts of Semen Cuscutae, 10 parts in Radix Rehmanniae Preparata, 6 parts of Bulbus Fritillariae Thunbergiis, 15 parts of Semen Benincasaes, 12 parts of Rhizoma Acori Graminei, 10 parts of Fructus Toosendans, 12 parts of Rhizoma Dioscoreaes, 8 parts of Rhizoma Curcumae, 15 parts of Caulis Sargentodoxaes, 10 parts of Semen Sinapis Albaes, 1 part of Lignum Aquilariae Resinatum, 12 parts of Radix Cyathulaes, 12 parts of Rhizoma Chuanxiongs, 2 parts of Sanguis Draxonis.
In order to reach better therapeutic effect, each component that also can contain following weight portion in the aforementioned pharmaceutical compositions: Moschus 0.1-1 part, Borneolum Syntheticum 0.05-0.5 part, prazosin 0.0005-0.002 part, diclofenac sodium 0.04-0.06 part, azithromycin 0.0002-0.0003 part;
Preferably, the weight portion of each component is: 0.5 part in Moschus, 0.2 part of Borneolum Syntheticum, 0.001 part of prazosin, 0.05 part of diclofenac sodium, 0.00025 part of azithromycin.
Chinese medicine composition of the present invention based on Chinese medicine to prostatitic pathogenetic research and Therapeutic Principle thereof, simultaneously according to the pharmaceutical research achievement, filter out activating blood circulation to dissipate blood stasis, vanishing sputum and dispelling knot, heat-clearing and toxic substances removing, the medicine that antiinflammatory relieves the pain according to the theory of Chinese medical science prescription, is prepared from according to certain weight proportion.
Among the present invention with activating blood circulation to dissipate blood stasis, vanishing sputum and dispelling knot, heat-clearing and toxic substances removing, the medicine that antiinflammatory relieves the pain is main, and cooperates point-application, medicine retention enema, by medicine per rectum mucosa, the acupuncture point directly penetrates, and arrives disease institute, improve bioavailability of medicament, again by the stimulation of medicine to the acupuncture point, the meridians conduction, excite through feeling pulse gas, dredging the meridian, reinforce insufficiency and reduce excessiveness, promote the internal organs QI-blood circulation, the state of body imbalance is tended to balance, reach and cure prostatitic purpose.
The present invention is monarch with the Carapax Trionycis, with the in love thing YIN nourishing hard masses softening and resolving of flesh and blood, and with Hirudo, Scolopendra, Pseudobulbus Cremastrae Seu Pleiones, Squama Manis, Rhizoma Corydalis, the Herba Lycopi, Sanguis Draxonis, Radix Notoginseng, Semen Persicae, succinum, Radix Cyathulae, Lignum Sappan, Rhizoma Chuanxiong, the pain relieving of Rhizoma Curcumae activating blood circulation to dissipate blood stasis, and can improve prostatic blood circulation, promote the unobstructed of prostate conduit, the drain of the resistance material that is beneficial to become silted up, and the reparation of the secretion of prostatic fluid and tissue, the Radix Astragali, Radix Ginseng, Rhizoma Dioscoreae tonification healthy energy is built up resistance, with strengthening body resistance and dispelling evil, Radix Rehmanniae Preparata, Carapax Et Plastrum Testudinis, Fructus Corni, the Semen Cuscutae nourishing the liver and kidney, tonifying both YIN and YANG is strengthened leukocytic phagocytosis.Pericarpium Citri Reticulatae Viride, Fructus Foeniculi, Fructus Toosendan, Rhizoma Chuanxiong, Lignum Aquilariae Resinatum, the promoting QI to circulate and dispersing the agglomeration of the pathogens pain relieving, Semen Benincasae, Semen Phaseoli, Caulis Sargentodoxae can be detoxified by clearing away heat-damp and promoting diuresis, the Rhizoma Pinelliae, Bulbus Fritillariae Thunbergii, the Semen Sinapis Albae vanishing sputum and dispelling knot, dampnessization is turbid, makes fibrosis organize softening gradually the absorption.Rhizoma Acori Graminei, Borneolum Syntheticum, Moschus promote the through sick institute of drug absorption.And cooperation Western medicine a～receptor blocking agent prazosin, can remove the spasm of neck of bladder and prostatic urethra, reducing urethral occlusive presses, preventing that prostatic urine is counter flows, act on sympathetic nerve at the bottom of the basin simultaneously, muscular spasm at the bottom of the releasing basin, tonicity myalgia at the bottom of alleviation perineum and the basin, it is a kind of novel potent anti-inflammatory analgesic that diclofenac is received, be the strong inhibitor of prostaglandin synthetase, can make the synthetic of prostaglandin and discharge minimizing, alleviate prostate patient's pain symptom preferably, and to frequent micturition, urgent micturition has the improvement effect.Azithromycin belongs to novel macrolide antibiotics, easily penetrates capsula prostatica, and antibacterial activity is strong, can kill to cause prostatitic various pathogens.The present invention also has positive effect to prostatic hyperplasia.
Semen Benincasae described in the present invention is the seed of cucurbitaceous plant Fructus Benincasae.Sweet in the mouth, cold nature.Return lung, large intestine channel.Function with cure mainly: removing heat from the lung and dissipating phlegm, eliminating carbuncle evacuation of pus, dampness removing.Cure mainly phlegm-heat cough, lung abscess, acute appendicitis, nebulousurine, leukorrhagia, beriberi, edema, stranguria.
Caulis Sargentodoxae described in the present invention is a Sargentodoxaceae fallen leaves bejuco Caulis Sargentodoxae SargentooxaCu-neataRehdetWils ratan.Nature and flavor, return through: bitter flat, go into large intestine channel.Function: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, wind dispelling insecticide.Be used for abdominalgia with intestinal abscess, rheumatic arthralgia, traumatic pain, dysmenorrhes, bloody dysentery, stranguria with blood, the infantile malnutrition worm is waited disease bitterly.
Carapax Trionycis described in the present invention is the carapace of Trionychidae animal Trionyx sinensis Wiegmann Trionyx sinensis Wiegmann.Property is salty and be slightly cold, and goes into liver, kidney channel.The function nourishing YIN for decreasing fever, hard masses softening and resolving.Be used for hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat; Consumption of YIN caused by febrile disease, night fever abating at dawn, wind symptom is twitched; The scar abdominal mass is gathered, diseases such as women's amenorrhea.
Carapax Et Plastrum Testudinis described in the present invention is carapace and the sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray).
The used crude drug of the present invention all can be bought from common Chinese material shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any oral formulations commonly used or external preparation, wherein, described oral formulations can be pill, capsule, tablet, powder, granule etc., is preferably pill; Described external preparation can be emplastrum, suppository etc.
The first method of preparation pharmaceutical composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by described weight portion: (quench in vinegar) Carapax Trionycis 10-30 part, (quench in vinegar) Carapax Et Plastrum Testudinis 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Squama Manis 0.5-3 part, Radix Astragali 10-20 part, Radix Ginseng 5-15 part, Rhizoma Corydalis 10-20 part, Herba Lycopi 10-20 part, Radix Notoginseng 1-6 part, Semen Persicae 5-12 part, Fructus Corni 9-15 part, succinum 1-6 part, Pericarpium Citri Reticulatae Viride 3-9 part, Semen Phaseoli 9-15 part, Fructus Foeniculi 9-15 part, Lignum Sappan 9-15 part, Rhizoma Pinelliae 5-12 part, Semen Cuscutae 10-20 part, Radix Rehmanniae Preparata 5-15 part, Bulbus Fritillariae Thunbergii 3-9 part, Semen Benincasae 10-20 part, Rhizoma Acori Graminei 9-15 part, Fructus Toosendan 5-15 part, Rhizoma Dioscoreae 9-15 part, Rhizoma Curcumae 5-12 part, Caulis Sargentodoxae 10-20 part, Semen Sinapis Albae 5-15 part, Lignum Aquilariae Resinatum 0.5-2 part, Radix Cyathulae 9-15 part, Rhizoma Chuanxiong 9-15 part and Sanguis Draxonis 1-4 part;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum and Sanguis Draxonis grind to form fine powder, and be standby; The decocting that remaining medicine is added 2-6 times of weight boils twice, filters in each one hour, merges the fine powder mix homogeneously of twice filtrate and above-mentioned grinding, adds after preparation uses adjuvant or carrier always, and preparations shaping obtains pill, capsule or tablet.
The second method of preparation pharmaceutical composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by described weight portion: (quench in vinegar) Carapax Trionycis 10-30 part, (quench in vinegar) Carapax Et Plastrum Testudinis 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Squama Manis 0.5-3 part, Radix Astragali 10-20 part, Radix Ginseng 5-15 part, Rhizoma Corydalis 10-20 part, Herba Lycopi 10-20 part, Radix Notoginseng 1-6 part, Semen Persicae 5-12 part, Fructus Corni 9-15 part, succinum 1-6 part, Pericarpium Citri Reticulatae Viride 3-9 part, Semen Phaseoli 9-15 part, Fructus Foeniculi 9-15 part, Lignum Sappan 9-15 part, Rhizoma Pinelliae 5-12 part, Semen Cuscutae 10-20 part, Radix Rehmanniae Preparata 5-15 part, Bulbus Fritillariae Thunbergii 3-9 part, Semen Benincasae 10-20 part, Rhizoma Acori Graminei 9-15 part, Fructus Toosendan 5-15 part, Rhizoma Dioscoreae 9-15 part, Rhizoma Curcumae 5-12 part, Caulis Sargentodoxae 10-20 part, Semen Sinapis Albae 5-15 part, Lignum Aquilariae Resinatum 0.5-2 part, Radix Cyathulae 9-15 part, Rhizoma Chuanxiong 9-15 part and Sanguis Draxonis 1-4 part;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum and Sanguis Draxonis grind to form fine powder, and be standby; Remaining crude drug is put into adding Oleum Sesami immersion in the iron pan; Oleum Sesami is heated to 120 degrees centigrade with high heat, the heating of reuse slow fire is exploded to pitchy up to crude drug, and one pinches when being broken, and it is clean to pull crude drug out filter; Medicine oil is poured in the conventional plaster substrate, stirred, be cooled to 60 degrees centigrade, put into the said medicine fine powder, stir, put into the cold water releasing fire-toxin, will spread out then on cotton, get emplastrum from fire.
The third method of preparation pharmaceutical composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by described weight portion: (quench in vinegar) Carapax Trionycis 10-30 part, (quench in vinegar) Carapax Et Plastrum Testudinis 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Squama Manis 0.5-3 part, Radix Astragali 10-20 part, Radix Ginseng 5-15 part, Rhizoma Corydalis 10-20 part, Herba Lycopi 10-20 part, Radix Notoginseng 1-6 part, Semen Persicae 5-12 part, Fructus Corni 9-15 part, succinum 1-6 part, Pericarpium Citri Reticulatae Viride 3-9 part, Semen Phaseoli 9-15 part, Fructus Foeniculi 9-15 part, Lignum Sappan 9-15 part, Rhizoma Pinelliae 5-12 part, Semen Cuscutae 10-20 part, Radix Rehmanniae Preparata 5-15 part, Bulbus Fritillariae Thunbergii 3-9 part, Semen Benincasae 10-20 part, Rhizoma Acori Graminei 9-15 part, Fructus Toosendan 5-15 part, Rhizoma Dioscoreae 9-15 part, Rhizoma Curcumae 5-12 part, Caulis Sargentodoxae 10-20 part, Semen Sinapis Albae 5-15 part, Lignum Aquilariae Resinatum 0.5-2 part, Radix Cyathulae 9-15 part, Rhizoma Chuanxiong 9-15 part, Sanguis Draxonis 1-4 part, Moschus 0.1-1 part, Borneolum Syntheticum 0.05-0.5 part, prazosin 0.0005-0.002 part, diclofenac sodium 0.04-0.06 part, azithromycin 0.0002-0.0003 part;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum, Sanguis Draxonis, Moschus, Borneolum Syntheticum, prazosin, diclofenac sodium and azithromycin grind to form fine powder, and be standby;
(3) decocting that remaining medicine is added 2-6 times of weight boils twice, filtered in each one hour, merging filtrate, be concentrated into the thick paste that proportion is 1.35-1.40 after, with stirrings that be mixed of the resulting fine powder of step (2), must ointment standby; With the cocoa butter heating, be added to above-mentioned ointment after the fusing and stir, formulation method is prepared into the suppository of per anum administration routinely, promptly.
Usage and consumption: the dosage of medicine of the present invention depends on concrete dosage form, and factor such as age of patient, body weight, health status.As guidance: (1) suppository, 1.8 gram/grains, the per anum administration, stype is inserted anal, and about 4 centimetres away from anus be, each bolt, twice of every day.(2) pill, each 6 grams, 3 times on the one.(3) emplastrum: every subsides 20 grams, be affixed on HUIYIN acupoint, SHENQUE acupoint, SHENYU acupoint, the Chihpien cave, Guanyuan acupoint, Zhongji acupoint, paste in every cave one, changed once in three days; Illustrate: the special role at each acupuncture point, Zhongji acupoint is the bladder the Mu-front acupoints, and the function of promote the circulation of qi and water tonneau urine is arranged.The Chihpien cave is the urinary bladder channel cave, but eliminating damp-heat, the effect of the tonneau part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, SHENQUE acupoint is fat-free mass herein, and peritoneum has abundant venous rete under the umbilicus, so drug absorption is rapid, be total pivot of meridians in addition herein, through the remittance sea of gas, thereby the stimulation promotion human nerve body fluid at acupuncture point is regulated, built up one's resistance to disease by medicine.SHENYU acupoint is by the tonification kidney yang, and diuretic leads to the effect of woods.Guanyuan acupoint is by kidney-boosting tonic, and unit is down mended in training, and diuresis ends the effect of losing.HUIYIN acupoint is nearest from prostate position, by drug effect and HUIYIN acupoint, can stimulate the regulatory function of pelvic cavity nerve, and regional flow is accelerated, and alleviates edema, promotes the absorption of inflammation, makes the medicine diseased region that goes directly, and heightens the effect of a treatment.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall within the scope of protection of the present invention the details of technical solution of the present invention and form.
The preparation of embodiment 1 pill
(1) takes by weighing each crude drug (unit: g): (quench in vinegar) Carapax Trionycis 10, (quench in vinegar) Carapax Et Plastrum Testudinis 10, Eupolyphaga Seu Steleophaga 0.5, Hirudo 0.1 by following weight, Scolopendra 0.2, Pseudobulbus Cremastrae Seu Pleiones 3, Squama Manis 0.5, the Radix Astragali 10, Radix Ginseng 5, Rhizoma Corydalis 10, the Herba Lycopi 10, Radix Notoginseng 1, Semen Persicae 5, Fructus Corni 9, succinum 1, Pericarpium Citri Reticulatae Viride 3, Semen Phaseoli 9, Fructus Foeniculi 9, Lignum Sappan 9, the Rhizoma Pinelliae 5, Semen Cuscutae 10, Radix Rehmanniae Preparata 5, Bulbus Fritillariae Thunbergii 3, Semen Benincasae 10, Rhizoma Acori Graminei 9, Fructus Toosendan 5, Rhizoma Dioscoreae 9, Rhizoma Curcumae 5, Caulis Sargentodoxae 10, Semen Sinapis Albae 5, Lignum Aquilariae Resinatum 0.5, Radix Cyathulae 9, Rhizoma Chuanxiong 9, Sanguis Draxonis 1;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum and Sanguis Draxonis grind to form fine powder, and be standby; The decocting that remaining medicine is added 2 times of weight boils twice, filters in each one hour, merges the fine powder mix homogeneously of twice filtrate and above-mentioned grinding, adds after preparation uses adjuvant or carrier always, and preparations shaping obtains pill.
The preparation of embodiment 2 pills
(1) takes by weighing each crude drug (unit: g): (quench in vinegar) Carapax Trionycis 30, (quench in vinegar) Carapax Et Plastrum Testudinis 20, Eupolyphaga Seu Steleophaga 3, Hirudo 1 by following weight, Scolopendra 2, Pseudobulbus Cremastrae Seu Pleiones 9, Squama Manis 3, the Radix Astragali 20, Radix Ginseng 15, Rhizoma Corydalis 20, the Herba Lycopi 20, Radix Notoginseng 6, Semen Persicae 12, Fructus Corni 15, succinum 6, Pericarpium Citri Reticulatae Viride 9, Semen Phaseoli 15, Fructus Foeniculi 15, Lignum Sappan 15, the Rhizoma Pinelliae 12, Semen Cuscutae 20, Radix Rehmanniae Preparata 15, Bulbus Fritillariae Thunbergii 9, Semen Benincasae 20, Rhizoma Acori Graminei 15, Fructus Toosendan 15, Rhizoma Dioscoreae 15, Rhizoma Curcumae 12, Caulis Sargentodoxae 20, Semen Sinapis Albae 15, Lignum Aquilariae Resinatum 2, Radix Cyathulae 15, Rhizoma Chuanxiong 15, Sanguis Draxonis 4;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum and Sanguis Draxonis grind to form fine powder, and be standby; The decocting that remaining medicine is added 6 times of weight boils twice, filters in each one hour, merges the fine powder mix homogeneously of twice filtrate and above-mentioned grinding, adds after preparation uses adjuvant or carrier always, and preparations shaping obtains pill.
The preparation of embodiment 3 emplastrumes
(1) takes by weighing each crude drug (unit: g): (quench in vinegar) Carapax Trionycis 20, (quench in vinegar) Carapax Et Plastrum Testudinis 15, Eupolyphaga Seu Steleophaga 1.5, Hirudo 0.5 by following weight, Scolopendra 1, Pseudobulbus Cremastrae Seu Pleiones 6, Squama Manis 1.5, the Radix Astragali 15, Radix Ginseng 10, Rhizoma Corydalis 15, the Herba Lycopi 15, Radix Notoginseng 3, Semen Persicae 8, Fructus Corni 12, succinum 3, Pericarpium Citri Reticulatae Viride 6, Semen Phaseoli 12, Fructus Foeniculi 12, Lignum Sappan 12, the Rhizoma Pinelliae 8, Semen Cuscutae 15, Radix Rehmanniae Preparata 10, Bulbus Fritillariae Thunbergii 6, Semen Benincasae 15, Rhizoma Acori Graminei 12, Fructus Toosendan 10, Rhizoma Dioscoreae 12, Rhizoma Curcumae 8, Caulis Sargentodoxae 15, Semen Sinapis Albae 10, Lignum Aquilariae Resinatum 1, Radix Cyathulae 12, Rhizoma Chuanxiong 12, Sanguis Draxonis 2;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum and Sanguis Draxonis grind to form fine powder, and be standby; Remaining crude drug is put into adding Oleum Sesami immersion in the iron pan; Oleum Sesami is heated to 120 degrees centigrade with high heat, the heating of reuse slow fire is exploded to pitchy up to crude drug, and one pinches when being broken, and it is clean to pull crude drug out filter; Medicine oil is poured in the conventional plaster substrate, stirred, be cooled to 60 degrees centigrade, put into the said medicine fine powder, stir, put into the cold water releasing fire-toxin, will spread out then on cotton, get emplastrum from fire.
The preparation of embodiment 4 suppositorys
(1) takes by weighing each crude drug (unit: g): Carapax Trionycis 10, Carapax Et Plastrum Testudinis 10, Eupolyphaga Seu Steleophaga 0.5, Hirudo 0.1 by following weight, Scolopendra 0.2, Pseudobulbus Cremastrae Seu Pleiones 3, Squama Manis 0.5, the Radix Astragali 10, Radix Ginseng 5, Rhizoma Corydalis 10, the Herba Lycopi 10, Radix Notoginseng 1, Semen Persicae 5, Fructus Corni 9, succinum 1, Pericarpium Citri Reticulatae Viride 3, Semen Phaseoli 9, Fructus Foeniculi 9, Lignum Sappan 9, the Rhizoma Pinelliae 5, Semen Cuscutae 10, Radix Rehmanniae Preparata 5, Bulbus Fritillariae Thunbergii 3, Semen Benincasae 10, Rhizoma Acori Graminei 9, Fructus Toosendan 5, Rhizoma Dioscoreae 9, Rhizoma Curcumae 5, Caulis Sargentodoxae 10, Semen Sinapis Albae 5, Lignum Aquilariae Resinatum 0.5, Radix Cyathulae 9, Rhizoma Chuanxiong 9, Sanguis Draxonis 1, Moschus 0.1, Borneolum Syntheticum 0.05, prazosin 0.0005, diclofenac sodium 0.04, azithromycin 0.0002;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum, Sanguis Draxonis, Moschus, Borneolum Syntheticum, prazosin, diclofenac sodium and azithromycin grind to form fine powder, and be standby;
(3) decocting that remaining medicine is added 2 times of weight boils twice, filtered in each one hour, merging filtrate, be concentrated into the thick paste that proportion is 1.35-1.40 after, with stirrings that be mixed of the resulting fine powder of step (2), must ointment standby; With the cocoa butter heating, be added to above-mentioned ointment after the fusing and stir, formulation method is prepared into the suppository of per anum administration routinely, promptly.
The preparation of embodiment 5 suppositorys
(1) takes by weighing each crude drug (unit: g): (quench in vinegar) Carapax Trionycis 30, (quench in vinegar) Carapax Et Plastrum Testudinis 20, Eupolyphaga Seu Steleophaga 3, Hirudo 1 by following weight, Scolopendra 2, Pseudobulbus Cremastrae Seu Pleiones 9, Squama Manis 3, the Radix Astragali 20, Radix Ginseng 15, Rhizoma Corydalis 20, the Herba Lycopi 20, Radix Notoginseng 6, Semen Persicae 12, Fructus Corni 15, succinum 6, Pericarpium Citri Reticulatae Viride 9, Semen Phaseoli 15, Fructus Foeniculi 15, Lignum Sappan 15, the Rhizoma Pinelliae 12, Semen Cuscutae 20, Radix Rehmanniae Preparata 15, Bulbus Fritillariae Thunbergii 9, Semen Benincasae 20, Rhizoma Acori Graminei 15, Fructus Toosendan 15, Rhizoma Dioscoreae 15, Rhizoma Curcumae 12, Caulis Sargentodoxae 20, Semen Sinapis Albae 15, Lignum Aquilariae Resinatum 2, Radix Cyathulae 15, Rhizoma Chuanxiong 15, Sanguis Draxonis 4, Moschus 1, Borneolum Syntheticum 0.5, prazosin 0.002, diclofenac sodium 0.06, azithromycin 0.0003;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum, Sanguis Draxonis, Moschus, Borneolum Syntheticum, prazosin, diclofenac sodium and azithromycin grind to form fine powder, and be standby;
(3) decocting that remaining medicine is added 6 times of weight boils twice, filtered in each one hour, merging filtrate, be concentrated into the thick paste that proportion is 1.35-1.40 after, with stirrings that be mixed of the resulting fine powder of step (2), must ointment standby; With the cocoa butter heating, be added to above-mentioned ointment after the fusing and stir, formulation method is prepared into the suppository of per anum administration routinely, promptly.
The preparation of embodiment 6 suppositorys
(1) takes by weighing each crude drug (unit: g): (quench in vinegar) Carapax Trionycis 20, (quench in vinegar) Carapax Et Plastrum Testudinis 15, Eupolyphaga Seu Steleophaga 1.5, Hirudo 0.5 by following weight, Scolopendra 1, Pseudobulbus Cremastrae Seu Pleiones 6, Squama Manis 1.5, the Radix Astragali 15, Radix Ginseng 10, Rhizoma Corydalis 15, the Herba Lycopi 15, Radix Notoginseng 3, Semen Persicae 8, Fructus Corni 12, succinum 3, Pericarpium Citri Reticulatae Viride 6, Semen Phaseoli 12, Fructus Foeniculi 12, Lignum Sappan 12, the Rhizoma Pinelliae 8, Semen Cuscutae 15, Radix Rehmanniae Preparata 10, Bulbus Fritillariae Thunbergii 6, Semen Benincasae 15, Rhizoma Acori Graminei 12, Fructus Toosendan 10, Rhizoma Dioscoreae 12, Rhizoma Curcumae 8, Caulis Sargentodoxae 15, Semen Sinapis Albae 10, Lignum Aquilariae Resinatum 1, Radix Cyathulae 12, Rhizoma Chuanxiong 12, Sanguis Draxonis 2, Moschus 0.5, Borneolum Syntheticum 0.2, prazosin 0.001, diclofenac sodium 0.05, azithromycin 0.00025;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum, Sanguis Draxonis, Moschus, Borneolum Syntheticum, prazosin, diclofenac sodium and azithromycin grind to form fine powder, and be standby;
(3) decocting that remaining medicine is added 4 times of weight boils twice, filtered in each one hour, merging filtrate, be concentrated into the thick paste that proportion is 1.35-1.40 after, with stirrings that be mixed of the resulting fine powder of step (2), must ointment standby; With the cocoa butter heating, be added to above-mentioned ointment after the fusing and stir, formulation method is prepared into the suppository of per anum administration routinely, promptly.
The clinical efficacy of test example 1 medicine composite for curing prostatitis of the present invention, prostatic hyperplasia is summed up
One, clinical physical data: this organizes 126 routine case histories, age 32-82 year; The shortest person of the course of disease 1 year, elder 26 years all is diagnosed as prostatitis or prostatic hyperplasia before all cases are treated, wherein, prostatitis patient 98 examples, prostatic hyperplasia patient 28 examples.
Two, whole patients are divided into 3 groups at random, every group 42 example; Wherein, the 1st group is adopted the embodiment of the invention 1 prepared pill to treat, each 6 grams, 3 times on the one; The 2nd group is adopted the embodiment of the invention 3 prepared emplastrumes to treat, and every subsides 20 grams are affixed on HUIYIN acupoint, SHENQUE acupoint, and SHENYU acupoint, the Chihpien cave, Guanyuan acupoint, Zhongji acupoint, paste in every cave one, changed once in three days; The 3rd group is adopted the embodiment of the invention 6 prepared suppositorys to treat, 1.8 gram/grains, and the per anum administration, stype is inserted anal, and about 4 centimetres away from anus be, each bolt, twice of every day.
Three, therapeutic outcome
The efficacy result of table 1 clinical treatment prostatitis, prostatic hyperplasia
Clinical test results shows that pharmaceutical composition of the present invention all has significant curative effect for prostatitis, prostatic hyperplasia, and any toxicity is not seen in clinical observation, and medicine drug safety of the present invention is described.
Claims (11)
1. treat prostatitis for one kind, the pharmaceutical composition of prostatic hyperplasia is made by each crude drug of following weight portion: Carapax Trionycis 10-30 part, Carapax Et Plastrum Testudinis 10-20 part, Eupolyphaga Seu Steleophaga 0.5-3 part, Hirudo 0.1-1 part, Scolopendra 0.2-2 part, Pseudobulbus Cremastrae Seu Pleiones 3-9 part, Squama Manis 0.5-3 part, Radix Astragali 10-20 part, Radix Ginseng 5-15 part, Rhizoma Corydalis 10-20 part, Herba Lycopi 10-20 part, Radix Notoginseng 1-6 part, Semen Persicae 5-12 part, Fructus Corni 9-15 part, succinum 1-6 part, Pericarpium Citri Reticulatae Viride 3-9 part, Semen Phaseoli 9-15 part, Fructus Foeniculi 9-15 part, Lignum Sappan 9-15 part, Rhizoma Pinelliae 5-12 part, Semen Cuscutae 10-20 part, Radix Rehmanniae Preparata 5-15 part, Bulbus Fritillariae Thunbergii 3-9 part, Semen Benincasae 10-20 part, Rhizoma Acori Graminei 9-15 part, Fructus Toosendan 5-15 part, Rhizoma Dioscoreae 9-15 part, Rhizoma Curcumae 5-12 part, Caulis Sargentodoxae 10-20 part, Semen Sinapis Albae 5-15 part, Lignum Aquilariae Resinatum 0.5-2 part, Radix Cyathulae 9-15 part, Rhizoma Chuanxiong 9-15 part and Sanguis Draxonis 1-4 part.
2. according to the described pharmaceutical composition of claim 1, it is characterized in that the weight portion of each crude drug is: 20 parts of Carapax Trionycis, 15 parts of Carapax Et Plastrum Testudiniss, 1.5 parts of Eupolyphaga Seu Steleophagas, 0.5 part of Hirudo, 1 part of Scolopendra, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, 1.5 parts of Squama Maniss, 15 parts of the Radixs Astragali, 10 parts of Radix Ginsengs, 15 parts of Rhizoma Corydalis, 15 parts of Herba Lycopi, 3 parts of Radix Notoginseng, 8 parts in Semen Persicae, 12 parts of Fructus Corni, 3 parts of succinums, 6 parts on Pericarpium Citri Reticulatae Viride, 12 parts of Semen Phaseolis, 12 parts of Fructus Foeniculi, 12 parts of Lignum Sappans, 8 parts of the Rhizoma Pinelliaes, 15 parts of Semen Cuscutae, 10 parts in Radix Rehmanniae Preparata, 6 parts of Bulbus Fritillariae Thunbergiis, 15 parts of Semen Benincasaes, 12 parts of Rhizoma Acori Graminei, 10 parts of Fructus Toosendans, 12 parts of Rhizoma Dioscoreaes, 8 parts of Rhizoma Curcumae, 15 parts of Caulis Sargentodoxaes, 10 parts of Semen Sinapis Albaes, 1 part of Lignum Aquilariae Resinatum, 12 parts of Radix Cyathulaes, 12 parts of Rhizoma Chuanxiongs, 2 parts of Sanguis Draxonis.
3. pharmaceutical composition for the treatment of prostatitis, prostatic hyperplasia, it is characterized in that, each component that on the basis of the crude drug of claim 1, also contains following weight portion: Moschus 0.1-1 part, Borneolum Syntheticum 0.05-0.5 part, prazosin 0.0005-0.002 part, diclofenac sodium 0.04-0.06 part, azithromycin 0.0002-0.0003 part.
4. according to the described pharmaceutical composition of claim 3, it is characterized in that the weight portion of each component is: 0.5 part in Moschus, 0.2 part of Borneolum Syntheticum, 0.001 part of prazosin, 0.05 part of diclofenac sodium, 0.00025 part of azithromycin.
5. any one described pharmaceutical composition of claim 1-4 is characterized in that: be prepared into any suitable clinically preparation according to Chinese medicine conventional formulation method.
6. according to the described pharmaceutical composition of claim 5, it is characterized in that: described preparation is oral formulations or external preparation.
7. method for preparing claim 1 or 2 described pharmaceutical compositions comprises:
(1) takes by weighing each crude drug by described weight portion;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum and Sanguis Draxonis grind to form fine powder, and be standby; The decocting that remaining medicine is added 2-6 times of weight boils twice, and each one hour, filter, merge the fine powder mix homogeneously of twice filtrate and above-mentioned grinding, add after preparation uses adjuvant or carrier always, preparations shaping obtains pill, capsule or tablet.
8. method for preparing claim 1 or 2 described pharmaceutical compositions comprises:
(1) takes by weighing each crude drug by described weight portion;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum and Sanguis Draxonis grind to form fine powder, and be standby; Remaining crude drug is put into adding Oleum Sesami immersion in the iron pan; Oleum Sesami is heated to 120 degrees centigrade with high heat, the heating of reuse slow fire is exploded to pitchy up to crude drug, and one pinches when being broken, and it is clean to pull crude drug out filter; Medicine oil is poured in the conventional plaster substrate, stirred, be cooled to 60 degrees centigrade, put into the said medicine fine powder, stir, put into the cold water releasing fire-toxin, will spread out then on cotton, get emplastrum from fire.
9. method for preparing claim 3 or 4 described pharmaceutical compositions comprises:
(1) takes by weighing each crude drug by described weight portion;
(2) with Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Squama Manis, Carapax Trionycis, Carapax Et Plastrum Testudinis, succinum, Lignum Aquilariae Resinatum, Sanguis Draxonis, Moschus, Borneolum Syntheticum, prazosin, diclofenac sodium and azithromycin grind to form fine powder, and be standby;
(3) decocting that remaining medicine is added 2-6 times of weight boils twice, each one hour, filter, merging filtrate, be concentrated into the thick paste that proportion is 1.35-1.40 after, with stirrings that be mixed of the resulting fine powder of step (2), must ointment standby; With the cocoa butter heating, be added to above-mentioned ointment after the fusing and stir, formulation method is prepared into the suppository of per anum administration routinely, promptly.
10. claim 1 or the 2 described pharmaceutical compositions purposes in the medicine of preparation treatment prostatitis, prostatic hyperplasia.
11. claim 3 or the 4 described pharmaceutical compositions purposes in the medicine of preparation treatment prostatitis, prostatic hyperplasia.
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| CN108175817A (en) * | 2017-12-29 | 2018-06-19 | 成都中医药大学附属医院 | It is a kind of to treat prostatitic pharmaceutical composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101940697B (en) * | 2010-09-16 | 2011-11-02 | 王之渊 | Medicament for treating prostatitis |
| CN102580011B (en) * | 2012-03-27 | 2013-11-13 | 山东中医药大学 | Navel fumigating traditional Chinese medicine composition for treating prostatitis |
| CN102716184A (en) * | 2012-07-02 | 2012-10-10 | 苏州纳晶医药技术有限公司 | Chinese medicinal composition and application thereof |
| CN103599472B (en) * | 2013-10-28 | 2015-08-26 | 李孔琳 | A kind of Chinese medicine composition being used for the treatment of prostatic hyperplasia |
| CN105582133A (en) * | 2014-09-12 | 2016-05-18 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine composition for treating prostatitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515307A (en) * | 2003-08-29 | 2004-07-28 | 石永龙 | Medicine for curing hysteromyoma |
| CN101085299A (en) * | 2006-06-07 | 2007-12-12 | 朱齐超 | Traditional Chinese medicinal composition for treating female pelvic inflammation and its application |
| CN101129793A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Traditional Chinese medicine composition for treating anormogenesis of mamma masculina |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1515307A (en) * | 2003-08-29 | 2004-07-28 | 石永龙 | Medicine for curing hysteromyoma |
| CN101085299A (en) * | 2006-06-07 | 2007-12-12 | 朱齐超 | Traditional Chinese medicinal composition for treating female pelvic inflammation and its application |
| CN101129793A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Traditional Chinese medicine composition for treating anormogenesis of mamma masculina |
Non-Patent Citations (2)
| Title |
|---|
| 桂泽红等.中医药治疗前列腺增生症的研究近况.《山西中医》.2001,第17卷(第04期), * |
| 王绍臣等.中西医结合治疗慢性前列腺炎300例.《山东中医杂志》.2000,第19卷(第10期), * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175817A (en) * | 2017-12-29 | 2018-06-19 | 成都中医药大学附属医院 | It is a kind of to treat prostatitic pharmaceutical composition and preparation method thereof |
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