CN101019910A - Use of Lindelofia stylosa as one borage family plant in preparing medicine for treating anroectal diseases - Google Patents
Use of Lindelofia stylosa as one borage family plant in preparing medicine for treating anroectal diseases Download PDFInfo
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- CN101019910A CN101019910A CN 200710048571 CN200710048571A CN101019910A CN 101019910 A CN101019910 A CN 101019910A CN 200710048571 CN200710048571 CN 200710048571 CN 200710048571 A CN200710048571 A CN 200710048571A CN 101019910 A CN101019910 A CN 101019910A
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Abstract
The present invention relates to the new use of Lindelofia stylosa as one kind of borage family plant, and is especially the use of Lindelofia stylosa or its extract in preparing medicine for treating piles, constipation, rectocele and other anorecta diseases. The medicine of Lindelofia stylosa is used in treating piles, constipation, rectocele and other anorecta diseases, and has the features of fast acting, determined and stable curative effect, capacity of improving the relevant physiological functions of human body, and capacity of raising resistance and life quality.
Description
Technical field
The present invention relates to the new purposes of Lindelofia stylosa as one borage family plant at field of medicaments.
Background technology
Hemorrhoid are human distinctive a kind of commonly encountered diseases, and frequently-occurring disease have saying of " ten people, nine hemorrhoid ".Just had reconnaissance information to show as far back as 1977, China's anal and intestinal disease prevalence is 59.1%, and hemorrhoid account for wherein 87.25%, visible hemorrhoid are big to human health risk.In recent years, the sickness rate of hemorrhoid is far above 1977, and to the development that becomes younger.Hemorrhoid are because the varicose of anus pad venous plexus, cause sludging and a kind of chronic disease of forming, and its symptom shows as: pain, weigh down expand, have blood in stool, constipation, prolapsus etc.The treatment of hemorrhoid method is a lot, can be divided into non-operative treatment and operative therapy substantially.Anorectal surgical of surgery branch of Chinese Medical Association is organized and held " seminar of hemorrhoid diagnosis and treatment tentative standard " in Chengdu, Sichuan in April, 2000 and worked out " hemorrhoid diagnosis and treatment tentative standard ", and hemorrhoid are defined as: " hemorrhoid are local agglomerates that anus pad pathologic hypertrophy, displacement and crissum veins beneath the skin clump stasis of blood stream form." this definition is the basis of re-recognizing hemorrhoid.The treatment of hemorrhoid principle is to eliminate symptom, should be to treatment of hemorrhoid based on non-operative treatment, and strict control operative treatment.But domestic at present, abroad be used for the treatment of in the medicine of hemorrhoid, remove medicine for external use, rarely seen evident in efficacy, easy to use, the oral drugs that expense is cheap.
Constipation is a kind of commonly encountered diseases, frequently-occurring disease.Feces overstays at enteral, so that times of defecation reduces constipation with dry stool, discharge difficulty or the constipation of meaning not to the utmost.The constipation pilosity is born in old people and women.The old people is because of insufficiency of vital energy and blood, gastrointestinal motor dysfunction and constipation takes place, and its sickness rate is higher 2～3 times than between twenty and fifty.The women is because of its physiological structure and endocrine reason, and the constipation sickness rate is higher than the male.Particularly the white collar women because operating pressure is big, lacks motion, and diet is too meticulous, bends over one's desk working for a long time etc., becomes the group of people at high risk of constipation.To the treatment of constipation, adopt except that the serious habitual constipation of minority the method such as coloclysis, all adopt the power type cathartic basically, phenolphthalein tablet for example, or be the Chinese medicine preparation etc. of main component with Radix Et Rhizoma Rhei, Folium Sennae, Natrii Sulfas etc.But this class medicine all has bigger side effect, takes for a long time to cause habitual constipation.
Proctoptosis, be rectum, anal canal emerging in downwards outside the anus after the bowel movement, be called proctoptosis, be commonly called as proctoptosis.Proctoptosis is many to be caused owing to flesh weakness or anal sphincter at the bottom of levator ani m. and the basin are lax.Can falling ill per capita of various ages, pilosity are born in children's's (supporting tissue hypoplasia in the Childhood pelvic cavity) and the old people's (getting old and weak) below 5 years old.Proctoptosis often has constipation, defecation irregular in the early stage, panesthesia's rectum completely expand and defecation unclean.Proctoptosis descends repeatedly and bounces back at internal rectum, causes the mucous hyperemia edema, often flows out a large amount of mucus and courageous and upright thing by anus.The patient often feels pelvic part and the lumbosacral region bob is expanded, pulled, perineal position and burst rear portion dull pain etc.The treatment of proctoptosis divides non-operative treatment and operative therapy.Non-operative treatment mainly is a Drug therapy, but does not still have the specific drug of treatment proctoptosis at present both at home and abroad.The method of operative treatment is a lot, fixes or suspension as rectum in the abdomen, and sigmoid colon and partial proctectomy, laser surgery treatment etc., but these method complication are more, the relapse rate height, and operating difficulty is big, and the expense costliness.
The Boraginaceae Cynoglossum (or make Herba Carpesii Cernui belong to, but its Latin generic name is Cynoglossum) plant, a tree name data introductions such as " Chinese Plants will ", about 28 kinds in the whole world, there is kind more than ten in China.The Lindelofia stylosa as one borage family plant form is close, and effect is similar, and it is the widest wherein to distribute, and most representative plant is Fructus Lithospermi Zollingeri, Herba Cynoglossi lanceolati and Herba Carpesii Cernui.
Carry according to " national Chinese herbal medicine compilation ": Fructus Lithospermi Zollingeri Cynoglossum zeylanicum (Vahl) Thunb.ex Lehm., annual herb, little hardship, cold; Clearing away heat-damp and promoting diuresis, promoting blood flow to regulate menstruation; Cure mainly hepatitis, menoxenia, leucorrhea, edema; External is usually used in treating furuncle carbuncle, venom, traumatic injury, fracture.Herba Cynoglossi lanceolati Cynoglossum lanceolatumForsk. is used as medicine with herb, root; Heat-clearing and toxic substances removing, inducing diuresis to remove edema is invigorated blood circulation; Cure mainly acute nephritis, menoxenia; Carbuncle sore tumefacting virus is controlled in external, venom.Herba Carpesii Cernui Cynoglossum amabile Stapf et Drumm. perennial herb; Sweet, bitter, cold; Clearing away heat-damp and promoting diuresis, dissipating blood stasis hemostasis, cough-relieving; Be used for malaria, hepatitis, dysentery, dysurea, leucorrhea, pulmonary tuberculosis cough; Wound hemorrhage is controlled in external, fracture, stremma.
Not about being that raw material and the pharmaceutical composition that contains Lindelofia stylosa as one borage family plant are applied to treat hemorrhoid, constipation, the relevant report of anal and intestinal diseases such as proctoptosis with the Lindelofia stylosa as one borage family plant separately.
Summary of the invention
Technical problem to be solved by this invention provides the new purposes of Lindelofia stylosa as one borage family plant.
Particularly, be the purposes of Lindelofia stylosa as one borage family plant in the medicine of preparation treatment anal and intestinal disease.Wherein, anal and intestinal disease is hemorrhoid, constipation, proctoptosis etc.
Another technical problem to be solved by this invention provides a kind of pharmaceutical composition for the treatment of anal and intestinal disease.
Pharmaceutical composition of the present invention is to be active component with the primary crude drug of the Lindelofia stylosa as one borage family plant of effective dose, processed product or extract, adds the medicament that acceptable accessories or complementary composition are prepared from.
The present invention treats hemorrhoid, proctoptosis and constipation with Lindelofia stylosa as one borage family plant, and is rapid-action, stable curative effect, and effective percentage can reach more than 90%, and the Cynoglossum plants wide material sources, and is with low cost, for the clinical treatment anal and intestinal disease provides new selection.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The invention provides the purposes of Lindelofia stylosa as one borage family plant in the medicine of preparation treatment anal and intestinal disease.
Particularly, be the purposes that is used for the treatment of in the anal and intestinal diseases such as constipation, hemorrhoid, proctoptosis.
Adopt the herb of Lindelofia stylosa as one borage family plant, as at least a herb among Fructus Lithospermi Zollingeri Cynoglossum zeylanicum (Vahl) Thunb.exLehm., Herba Cynoglossi lanceolati Cynoglossum lanceolatum Forsk., the Herba Carpesii Cernui Cynoglossum amabileStapf et Drumm., also can adopt the herb of other Lindelofia stylosa as one borage family plant.
For convenience the patient takes, and primary crude drug water or organic solvent can be prepared extract, adds acceptable accessories again or complementary composition is prepared into various medicaments.Described organic solvent is meant the solvent of opposed polarities such as ethanol, methanol.
Medicament is oral formulations, external preparation or ejection preparation
Further, described oral formulations is decoct, powder, bag bubble electuary, tablet, tincture, pill, extractum, oral liquid, capsule or granule; Described external preparation is ointment or suppository.
Effective dose in the described medicament is counted 5～30 grams by taking the Lindelofia stylosa as one borage family plant primary crude drug every day; Or effective dose is counted 0.2～2 gram by taking Lindelofia stylosa as one borage family plant water extract or extractive with organic solvent every day.
The inventor is the preparation that active component is prepared from the Lindelofia stylosa as one borage family plant, is used for the treatment of anal and intestinal diseases such as constipation, hemorrhoid, proctoptosis, and curative effect is sure, and effective percentage can reach more than 90%.
Be used for the treatment of hemorrhoid, to I, II phase internal hemorrhoid and the lighter external hemorrhoid of the state of an illness, mixed hemorrhoid, general medication 5～7 days can be eliminated symptom; To the heavier III phase internal hemorrhoid of the state of an illness and external hemorrhoid, mixed hemorrhoid patient, general medication 15～30 days, be aided with the Lindelofia stylosa as one borage family plant preparation simultaneously and ZHICHUANG GAO or stype, can eliminate symptom.The patient take with Lindelofia stylosa as one borage family plant preparation and preparation eliminate symptom after, the asymptomatic stage length of holding time, relapse rate is low.
Be used for the treatment of particularly imperfection proctoptosis of proctoptosis, general medication 7～15 days, transference cure, rectum is no longer deviate from; The completeness proctoptosis heavier to symptom, medication 1～2 month generally can both reach transference cure, the effect that rectum is no longer deviate from.With Lindelofia stylosa as one borage family plant preparation and preparation tight and fecal incontinence also has better curative effect to proctatresia.
Be used for the treatment of constipation, often can receive the effect that As the medicine took effect, the symptoms lessened, and property of medicine gentleness, rapid-action, stable curative effect has no side effect.To slight constipation patient, general medication 2～3 days, the patient heavier to state of an illness such as habitual constipations, general medication 15～30 days can be fully recovered.Its therapeutic effect is better than many loosening bowel to relieve constipation medicines in the market, to having better effect of gerontal patient.
The Lindelofia stylosa as one borage family plant form is very close, and difficult their are distinguished come, particularly Shou Gou dry product.When from the masses, purchasing the medical material dry product,, all be mixture basically based on the Lindelofia stylosa as one borage family plant of Fructus Lithospermi Zollingeri, Herba Cynoglossi lanceolati and Herba Carpesii Cernui no matter be purchase Fructus Lithospermi Zollingeri, Herba Cynoglossi lanceolati or purchase Herba Carpesii Cernui.So used Lindelofia stylosa as one borage family plant is at least two kinds of blended dry products in Fructus Lithospermi Zollingeri, Herba Cynoglossi lanceolati and the Herba Carpesii Cernui of purchasing in market among the embodiment, is called for short Lindelofia stylosa as one borage family plant among the embodiment.
The preparation of embodiment 1 tablet of the present invention
Get Lindelofia stylosa as one borage family plant 500g, press 15 water logging bubbles 1 hour extraordinarily of dose, put Decocting pot and endured 1 hour, leach medicinal liquid, add 10 times of decoctings 1 hour again, leach medicinal liquid, merge medicinal liquid twice, dehydration is concentrated into the thick paste shape, adds 15% soluble starch dextrin and (or adds isodose 200 order crude drug powder, mixing, 60 ℃ of oven dry are pulverized, add 1% magnesium stearate mixing, cross 20 mesh sieve granulate, tabletting, the heavy 0.5g (every gram is equivalent to crude drug 5g) of sheet.Instructions of taking: each 2～3, three times on the one.
The preparation of embodiment 2 medicinal tea of the present invention
Get Lindelofia stylosa as one borage family plant 1kg, Radix Glycyrrhizae 80g, the common pulverizing crossed 60～80 mesh sieves, packs into teabag by every bag of 3～5g with filter paper on bag tea machine.Instructions of taking: three bags of every days, early, middle and late each one bag.Medicated bag is put into thermos cup, brew with boiled water and drink after 20～30 minutes.This teabag glycol is good to eat, can drink throughout the year, also can drink by dose 1/10 adding Folium Camelliae sinensis or Radix Et Rhizoma Fagopyri Tatarici.
The preparation of embodiment 3 water decoctions of the present invention
Get Lindelofia stylosa as one borage family plant 30g, Radix Glycyrrhizae 1～3g adds 10～15 times in water, soaks 1 hour, inserts Decocting pot, fries in shallow oil one hour, pours out medicinal liquid, adds 10 times of water again, fries in shallow oil 30 minutes, merges decocting liquid twice, and early, middle and late branch takes for three times.
The preparation of embodiment 4 medicine capsules of the present invention
Get Lindelofia stylosa as one borage family plant 500g, press 15 water logging bubbles 1 hour extraordinarily of dose, put Decocting pot and endured 1 hour, leach medicinal liquid, add 10 times of decoctings 1 hour again, leach medicinal liquid, merge medicinal liquid twice, dehydration is concentrated into the thick paste shape, add 20%200 order crude drug powder,, pulverize 60 ℃ of dryings.This medicated powder is made capsule (every gram is equivalent to crude drug 5 grams) by every explosive payload 0.4g.Instructions of taking: each 2～3, three times on the one.
The preparation of embodiment 5 oral liquids of the present invention
Get Lindelofia stylosa as one borage family plant 500g, Radix Glycyrrhizae 10～20g presses 15 water logging bubbles 1 hour extraordinarily of dose, puts Decocting pot and endures 1 hour, leach medicinal liquid, add 10 times of decoctings 1 hour again, leach medicinal liquid, merge medicinal liquid twice, dehydration is concentrated into density d=1.2～1.3 (70～80 ℃ of surveys), this medicinal liquid is loaded on (every 10ml is equivalent to crude drug 2.5g) in the 10ml glass bottle, seals, steam sterilization gets final product.This product does not contain antiseptic, and glycol is good to eat.Usage: oral, one time 1～2, every day three times.
The preparation of embodiment 6 injections of the present invention
Get Lindelofia stylosa as one borage family plant 2kg, 15 times of adding distil waters boiled 1 hour, filter, residue adds 10 times of decocting in water 1 hour again, filters, merging filtrate is concentrated into the thick paste shape, adds 96% ethanol, make and contain alcohol amount and reach 80%, place after 24 hours, sucking filtration reclaims ethanol, after twice of the repeated precipitation, with filtrate adding distil water to 800 milliliter.Add 1% active carbon, sucking filtration, filtrate adding distil water to 1000 milliliter is heated to 80 ℃, adds 2% benzyl alcohol, and sucking filtration is to clear and bright repeatedly, in 2 milliliters of ampoules of embedding (every milliliter is equivalent to contain crude drug 2g), steam sterilization 30 minutes, standby.Intramuscular injection, one day twice, each 2 milliliters.
The preparation of embodiment 7 suppositorys of the present invention
Get Lindelofia stylosa as one borage family plant 150g, add 10～15 times in water, soaked 1 hour, insert Decocting pot, decoct 1 hour, pour out medicinal liquid, add 10 times of water again, fried in shallow oil 30 minutes, merge decocting liquid twice; Concentrate decocting liquid to dried cream, add Borax 10g, Borneolum Syntheticum 10g, pulverizing, porphyrize; Get S-40 500g and melt in water-bath, the dried cream fine powder of porphyrize is added grind in the above-mentioned substrate evenly, insulation is irritated mould and is got final product.
The preparation of embodiment 8 ointments of the present invention
Get Lindelofia stylosa as one borage family plant 150g, add 10～15 times in water, soaked 1 hour, insert Decocting pot, decoct 1 hour, pour out medicinal liquid, add 10 times of water again, fried in shallow oil 30 minutes, merge decocting liquid twice; Concentrate decocting liquid to dried cream, add Borax 10g, Borneolum Syntheticum 10g, pulverizing, porphyrize; Taking polyethylene glycol 3350 400g, PEG400 600g mix two kinds of Polyethylene Glycol, are heated to 65 ℃ in water-bath, are stirred to condensation, promptly; The dried cream fine powder of porphyrize is added in the substrate of condensation, and mix homogeneously gets final product.
Below be used for the treatment of the beneficial effect of anal and intestinal diseases such as hemorrhoid, constipation, proctoptosis by the test of pesticide effectiveness and clinical case statistical confirmation Lindelofia stylosa as one borage family plant.
One, treatment hemorrhoid clinical case statistics: gained clinical case treatment standard is all carried out according to working out " hemorrhoid diagnosis and treatment tentative standard " in April, 2000.Treatment hemorrhoid patients 43 examples, wherein, male's 27 examples account for 62.79%, and female patient 16 examples account for 37.20%.Age accounts for 24 examples more than 44.19%, 50 years old 30～50 years old patient's 19 example, accounts for 55.81%.Its therapeutic outcome such as following table:
Table 1 clinical case statistics
| Group | Patient's classification | Patient's number | Therapeutic outcome | Cure rate (%) | Effectively (%) | |
| Cure (people) | Produce effects (people) | |||||
| One group | I, II phase internal hemorrhoid and mixed hemorrhoid | 35 | 35 | 0 | 100 | 100 |
| Two groups | III phase internal hemorrhoid and mixed hemorrhoid | 8 | 5 | 2 | 62.5 | 87.5 |
| Add up to | 43 | 40 | 2 | 93.02 | 97.67 | |
To two groups of patients' treatment, most of teabag electuary (press embodiment 2 preparations) that adopts, every bag 4 restrains, and three bags of every days, brews with boiled water and to take after 30 minutes.First group of patient's medication 3～7 days, most of patient's symptom is eliminated substantially, and after individual patient was obeyed 2～3 days medicines more, symptom also disappeared substantially.Second group of patient, there are 4 people to take capsule (embodiment 4 preparations), there are 4 people to take decoct (embodiment 3 preparations), press crude drug 12～15 grams every day, divide and take orally for early, middle and late three times, be aided with suppository (embodiment 7 preparations) simultaneously, treated 15～30 days, 5 people's transference cures, 2 people's symptoms are clearly better, and a people is invalid.
Two, constipation: through patient's oral account, in the hemorrhoid patients, the people suffers from constipation simultaneously greatly, and when the treatment hemorrhoid, constipation is at first fully recovered often.No matter be simple constipation or complication, the effective percentage of treatment constipation is more than 90%.
Three, proctoptosis: treatment proctoptosis 6 people, imperfection proctoptosis 4 people, completeness proctoptosis 2 people, the age is in 60-70 year.Therapeutic outcome, imperfection proctoptosis 3 people recovery from illness, 1 people is clearly better; The completeness proctoptosis 1 people be almost recovered, and 1 people is effective.
Model case:
1, man, 73 years old, retirement.Year surplus the trouble hemorrhoid ten, did hemorrhoid operation in 1992, the postoperative several years, the hemorrhoid recurrence, at every turn greatly after an action of the bowels, hemorrhoid are deviate from, and as the Semen Juglandis size, can not also receive, and need also receive with hands after washing, fill in ZHICHUAN SHUAN again.Took tablet of the present invention (embodiment 1 preparation) more than ten day, hemorrhoid are obviously dwindled, and blood stasis is no longer deviate from after an action of the bowels.So far half a year is many, does not see recurrence.
2, man 42 years old, is employed.Year surplus the trouble hemorrhoid ten, painless, but often hemorrhage, the hemorrhage spurting that is when serious, blood can all soak inside and outside trousers.Sometimes blood stasis is deviate from, as the Semen Viciae fabae size.Take surplus the medicinal tea 20 of the present invention day, hemorrhoid are dwindled, and idol has the blood streak on the toilet paper after an action of the bowels, but does not have massive hemorrhage again.Later all sittings, drink after, in time take 2 doses of medicinal tea of the present invention (embodiment 2 preparation), the several months are not seen recurrence.
3, man, 72 years old, retirement.Suffered from hemorrhoid more than 20 year, did hemorrhoid operation before more than ten years, post-surgical condition is fair.Hemorrhoid recurrence after several years, the life-time service ZHICHUANG GAO, the state of an illness increased the weight of in recent years, had formed incarceration, through taking capsule of the present invention (embodiment 4 preparations) recovery from illness in more than ten day, nearly so far 1 year, did not see recurrence.
4, man, 83 years old, the owner of a private enterprise.Suffer from serious habitual constipation more than ten years, stool is stiff graininess, and defecation is extremely difficult, usually needs pluck out with hands.The patient takes phenolphthalein tablet, SANHUANG PIAN, cow-bezoar anti-toxic bolus, glycerin for a long time, and coloclysis repeatedly.Though through in, western medical treatment, the state of an illness commentaries on classics of not getting better.Take medicinal tea of the present invention (embodiment 2 preparation) after 3 days symptom obviously alleviate, took medicine 7 days, stool is strip, the wheat harvesting period that continues to take medicine recovery from illness.
5, man, 75 years old, retirement.Suffer from proctoptosis more than ten years, often rectum is deviate from greatly after an action of the bowels, does not have effective Therapeutic Method always, and is very painful.Take decoct of the present invention (embodiment 3 preparations) after 5 days, rectum is no longer deviate from, and recovery from illness in more than ten day continues to take medicine.
6, man, 64 years old, retirement.Nearly more than 20 years of habitual constipation, the life-time service phenolphthalein tablet, PAIDU YANGYAN JIAONANG, intestinal green tea, medicines such as glycerin, must take medicine every day, and the drug withdrawal constipation is promptly recurred.Recent months is taken intestinal green tea, and loose stool is the bean dregs shape, and every day, defecation was more than 2～3 times.Take tablet of the present invention (embodiment 1 preparation) after 4 days, defecation is unobstructed, and stool matter is soft, strip, and every day, defecation was 1～2 time.Continue to take medicine and fully recover behind the wheat harvesting period.
Above-mentioned clinical trial has reflected that directly Lindelofia stylosa as one borage family plant is that the preparation that active component is prepared from has significant curative effect to anal and intestinal diseases such as hemorrhoid, constipation, proctoptosis, and safely, have no side effect.And owing to belong to crude drug, and wide material sources, with low cost, for the clinical treatment anal and intestinal disease provides new selection.
Claims (9)
1, the purposes of Lindelofia stylosa as one borage family plant in the medicine of preparation treatment anal and intestinal disease.
2, purposes according to claim 1 is characterized in that: described anal and intestinal disease is hemorrhoid.
3, purposes according to claim 1 is characterized in that: described anal and intestinal disease is constipation.
4, purposes according to claim 1 is characterized in that: described anal and intestinal disease is a proctoptosis.
5, according to each described purposes of claim 1～4, it is characterized in that: described Lindelofia stylosa as one borage family plant is an at least a herb among Fructus Lithospermi Zollingeri Cynoglossum zeylanicum (Vahl) Thunb.ex Lehm., Herba Cynoglossi lanceolati Cynoglossumlanceolatum Forsk. or the Herba Carpesii Cernui Cynoglossum amabile Stapf et Drumm..
6, the pharmaceutical composition of treatment anal and intestinal disease, it is to be active component with the primary crude drug of the Lindelofia stylosa as one borage family plant of effective dose, processed product or extract, adds the medicament that acceptable accessories or complementary composition are prepared from.
7, the pharmaceutical composition of treatment anal and intestinal disease according to claim 6 is characterized in that: described effective dose is counted 5～30 grams by taking the Lindelofia stylosa as one borage family plant primary crude drug every day; Or effective dose is counted 0.2～2 gram by taking Lindelofia stylosa as one borage family plant water extract or extractive with organic solvent every day.
8, the pharmaceutical composition of treatment anal and intestinal disease according to claim 6 is characterized in that: described medicament is oral formulations, external preparation or ejection preparation.
9, medicine according to claim 8 or pharmaceutical composition is characterized in that: described oral formulations is decoct, powder, bag bubble electuary, tablet, tincture, pill, extractum, oral liquid, capsule or granule; Described external preparation is ointment or suppository.
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| CN101411755B (en) * | 2008-06-03 | 2011-09-21 | 陈德顺 | Oral Chinese medicine for treating constipation with heat retention |
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| CN101411755B (en) * | 2008-06-03 | 2011-09-21 | 陈德顺 | Oral Chinese medicine for treating constipation with heat retention |
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