CN1931287B - Chinese medicine composition for treating piles and its preparation process - Google Patents
Chinese medicine composition for treating piles and its preparation process Download PDFInfo
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- CN1931287B CN1931287B CN2006101597759A CN200610159775A CN1931287B CN 1931287 B CN1931287 B CN 1931287B CN 2006101597759 A CN2006101597759 A CN 2006101597759A CN 200610159775 A CN200610159775 A CN 200610159775A CN 1931287 B CN1931287 B CN 1931287B
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Abstract
The present invention discloses one kind of Chinese medicine composition for treating piles, and belongs to the field of Chinese medicine technology. The Chinese medicine composition is prepared with pagodatree fruit, garden burnet, rhubarb, skullcap root, dandeliion and other Chinese medicinal materials. The Chinese medicine composition has obvious curative effect on piles. The present invention also discloses the preparation process of the Chinese medicine composition.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of hemorrhoid and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Hemorrhoid are to occur in anal outer commonly encountered diseases, frequently-occurring disease.According to statistics, the sickness rate of anal and intestinal disease is 59.1%, and wherein hemorrhoid account for 88.25% of sickness rate, though its non-serious disease is often had blood in stool, swollen and ache during owing to morbidity, with the passing of time also can cause secondary anemia etc.
Adopt operative therapy, laser therapy, acupuncture and moxibustion treatment, fumigation and wash method external application therapy etc. for treatment of hemorrhoid clinically more, and less with the oral drugs therapy, common in the market only have a few kind, and lighter I, the II phase patient of most of hemorrhoid patients, the especially state of an illness all wishes to take more convenient oral drugs conservative treatment.The present invention increases the purpose of clinical dosage form in line with making things convenient for the patient, develops on the basis of clinical experience for many years.
Summary of the invention
One of purpose of the present invention provides a kind of Chinese medicine composition.
Two of purpose of the present invention provides the preparation method of this Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions:
Medicine of the present invention is made by following bulk drugs:
Fructus Sophorae 200-600 weight portion Radix Sanguisorbae 200-600 weight portion Radix Et Rhizoma Rhei 75-225 weight portion
Radix Scutellariae (wine is processed) 150-450 weight portion Herba Taraxaci 150-450 weight portion Herba Senecionis Scandentis 150-450 weight portion
Herba Violae 150-450 weight portion Radix Paeoniae Rubra 175-525 weight portion Fructus Aurantii (parched with bran) 150-450 weight portion
Radix Glycyrrhizae 100-300 weight portion.
Medicine optimum weight part proportioning of the present invention is:
The Fructus Sophorae 400 weight portion Radix Sanguisorbaes 400 weight portion Radix Et Rhizoma Rhei 150 weight portions
Radix Scutellariae (wine is processed) 300 weight portion Herba Taraxacis 300 weight portion Herba Senecionis Scandentiss 300 weight portions
Herba Violae 300 weight portion Radix Paeoniae Rubra 350 weight portion Fructus Aurantiis (parched with bran) 300 weight portions
Radix Glycyrrhizae 200 weight portions.
Above crude drug can be made multiple oral formulations, comprises oral liquid, tablet, capsule, soft capsule, granule, pill etc., and the common preparation process of these preparations is:
More than ten flavors, Fructus Aurantii use steam distillation, collects distillate, the device collection in addition of the aqueous solution after the distillation is standby.Nine flavors such as medicinal residues and all the other Radix Et Rhizoma Rhei decoct with water two～four times, collecting decoction filters, and filtrate and above-mentioned water liquid merge, concentrate, precipitate with ethanol adds 40% sodium hydroxide solution and regulates pH to 6.0～7.0, standing over night, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, merge with above-mentioned distillate, standby, make required dosage form.
Common dosage form and preparation method are:
Add correctives, antiseptic in mixed liquor, oral liquid is made in fill.
Mixed liquor is concentrated, dry, add appropriate amount of auxiliary materials, tabletting is prepared into tablet.
Mixed liquor is concentrated, dry, add appropriate amount of auxiliary materials, granulate, incapsulate, be prepared into capsule.
Mixed liquor is concentrated, dry, add appropriate amount of auxiliary materials, granulate, be prepared into granule.
Mixed liquor is concentrated, dry, add substrate, antiseptic, mixing is prepared into soft capsule.
Mixed liquor is concentrated, dry, add appropriate amount of auxiliary materials, be prepared into pill.
Best preparation method is:
More than ten flavors, Fructus Aurantii use steam distillation, collects distillate, the device collection in addition of the aqueous solution after the distillation is standby.Nine flavors such as medicinal residues and all the other Radix Et Rhizoma Rhei decoct with water three times, and each 50 minutes, amount of water was respectively 6,5,5 times, collecting decoction, filter, filtrate and above-mentioned water liquid merge, and are concentrated into relative density 1.18 ~ 1.20 (60 ℃), add ethanol and make that to contain alcohol amount be 60%, add 40% sodium hydroxide solution and regulate pH to 6.0 ~ 7.0, standing over night is got the supernatant decompression recycling ethanol to there not being the alcohol flavor, merge with above-mentioned distillate, add ethyl hydroxybenzoate 0.5g, adding water to total amount is 1000ml, and regulates pH value to 4.0 ~ 6.0, stir evenly, leave standstill, filter embedding, sterilization, promptly.
This product can be used for treating hemorrhoid, for determining drug effect, this product has been carried out pharmacodynamics test research, and used oral liquid is by best proportioning of the present invention and optimum process preparation and get in the test.Concrete test is as follows:
1, mice auricle swelling test
Test method: get mice male and female half and half, the back random packet of weighing, normal saline (NS) group all adopts gastric infusion (ig) with this product group, once a day, continuous 4 days.Positive controls adopts lumbar injection (ip), 1 administration.30min after the medication evenly is applied to mouse right ear with 100% dimethylbenzene 0.04ml the last time, causes scorching back 30min and puts to death animal, preparation mice auricle is weighed, with auricle swelling degree (two auricle weight poor) as inflammation index, calculate the inhibitory rate of intumesce of medication group, the results are shown in Table 1.
Table 1 this product is to the influence of mice ear (X ± s)
Show that this product has the good restraining effect to mice ear.
2, mouse writhing test
Test method: get mice, male and female half and half, random packet, medication is the same.30min after last administration, ip0.05% antimony potassium tartrate 0.2ml are only
-1, observe mouse writhing total degree in the 10min.The results are shown in Table 2.
Show that this product has certain analgesic activity to mice.
Above-mentioned pharmacology test shows that this product has fine many anti-inflammatory analgesic effect, and prompting has good curative effect for treatment of hemorrhoid.
Below by implementing to further specify technical scheme of the present invention, but this applies for that claimed scope is not limited in the described content of embodiment.
The specific embodiment:
Embodiment 1
[prescription] Fructus Sophorae 400g Radix Sanguisorbae 400g Radix Et Rhizoma Rhei 150g
Radix Scutellariae 300g Herba Taraxaci 300g Herba Senecionis Scandentis 300g
Herba Violae 300g Radix Paeoniae Rubra 350g Fructus Aurantii 300g
Radix Glycyrrhizae 200g
[method for making] above ten flavors, Fructus Aurantii is used steam distillation, collects distillate, and the aqueous solution after distillation device is in addition collected, and is standby.Nine flavors such as medicinal residues and all the other Radix Et Rhizoma Rhei decoct with water three times, and each 50 minutes, amount of water was respectively 6,5,5 times, collecting decoction, filter, filtrate and above-mentioned water liquid merge, and are concentrated into relative density 1.18～1.20 (60 ℃), add ethanol and make that to contain alcohol amount be 60%, add 40% sodium hydroxide solution and regulate pH to 6.0～7.0, standing over night is got the supernatant decompression recycling ethanol to there not being the alcohol flavor, merge with above-mentioned distillate, add ethyl hydroxybenzoate 0.5g, adding water to total amount is 1000ml, and regulates pH value to 4.0～6.0, stir evenly, leave standstill, filter embedding, sterilization, promptly.
Embodiment 2
[prescription] Fructus Sophorae 200g Radix Sanguisorbae 200g Radix Et Rhizoma Rhei 75g
Radix Scutellariae 150g Herba Taraxaci 150g Herba Senecionis Scandentis 150g
Herba Violae 150g Radix Paeoniae Rubra 175g Fructus Aurantii 150g
Radix Glycyrrhizae 100g
[method for making] above ten flavors, Fructus Aurantii is used steam distillation, collects distillate, and the aqueous solution after distillation device is in addition collected, and is standby.Nine flavors such as medicinal residues and all the other Radix Et Rhizoma Rhei decoct with water three times, each 50 minutes, amount of water was respectively 6,5,5 times, collecting decoction, filter, filtrate and above-mentioned water liquid merge, and are concentrated into relative density 1.18～1.20 (60 ℃), add ethanol and make that to contain the alcohol amount be 60%, add 40% sodium hydroxide solution and regulate pH to 6.0～7.0, standing over night is got the supernatant decompression recycling ethanol to there not being the alcohol flavor, continues to concentrate and the blood pressure lowering drying, pulverize, with sucrose 100g, dextrin is an amount of, mixing, granulate, oven dry is made granule 500g, promptly.
Embodiment 3
[prescription] Fructus Sophorae 800g Radix Sanguisorbae 800g Radix Et Rhizoma Rhei 300g
Radix Scutellariae 600g Herba Taraxaci 600g Herba Senecionis Scandentis 600g
Herba Violae 600g Radix Paeoniae Rubra 700g Fructus Aurantii 600g
Radix Glycyrrhizae 400g
[method for making] above ten flavors, Fructus Aurantii is used steam distillation, collects distillate, and the aqueous solution after distillation device is in addition collected, and is standby.Nine flavors such as medicinal residues and all the other Radix Et Rhizoma Rhei decoct with water three times, each 50 minutes, amount of water is respectively 6,5,5 times, collecting decoction filters, and filtrate and above-mentioned water liquid merge, be concentrated into relative density 1.18～1.20 (60 ℃), add ethanol and make that to contain alcohol amount be 60%, add 40% sodium hydroxide solution and regulate pH to 6.0～7.0, standing over night, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, continue to concentrate and the blood pressure lowering drying, pulverize, add carboxymethyl starch sodium 10g, and add microcrystalline Cellulose adjusting total amount to 600g, tabletting is made 2000, promptly.
Claims (6)
1. Chinese medicine composition for the treatment of hemorrhoid is characterized in that this Chinese medicine composition made by following raw material medicaments:
Fructus Sophorae 200-600 weight portion Radix Sanguisorbae 200-600 weight portion Radix Et Rhizoma Rhei 75-225 weight portion
Radix Scutellariae 150-450 weight portion Herba Taraxaci 150-450 weight portion Herba Senecionis Scandentis 150-450 weight portion
Herba Violae 150-450 weight portion Radix Paeoniae Rubra 175-525 weight portion Fructus Aurantii 150-450 weight portion
Radix Glycyrrhizae 100-300 weight portion.
2. Chinese medicine composition according to claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
The Fructus Sophorae 400 weight portion Radix Sanguisorbaes 400 weight portion Radix Et Rhizoma Rhei 150 weight portions
Radix Scutellariae 300 weight portion Herba Taraxacis 300 weight portion Herba Senecionis Scandentiss 300 weight portions
Herba Violae 300 weight portion Radix Paeoniae Rubra 350 weight portion Fructus Aurantiis 300 weight portions
Radix Glycyrrhizae 200 weight portions.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that making oral liquid, tablet, capsule, granule, pill.
4. according to the preparation method of the described Chinese medicine composition of claim 3, it is characterized in that the steps include: above ten flavors, Fructus Aurantii is used steam distillation, collects distillate, and the aqueous solution after distillation device is in addition collected, and is standby.Nine flavors such as medicinal residues and all the other Radix Et Rhizoma Rhei decoct with water two～four times, collecting decoction filters, and filtrate and above-mentioned water liquid merge, concentrate, precipitate with ethanol adds 40% sodium hydroxide solution and regulates pH to 6.0～7.0, standing over night, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, merge with above-mentioned distillate, standby, make required dosage form.
5. according to the preparation method of the described Chinese medicine composition of claim 4, it is characterized in that the steps include: above ten flavors, Fructus Aurantii is used steam distillation, collects distillate, and the aqueous solution after distillation device is in addition collected, and is standby.Nine flavors such as medicinal residues and all the other Radix Et Rhizoma Rhei decoct with water three times, and each 50 minutes, amount of water was respectively 6,5,5 times, collecting decoction, filter, filtrate and above-mentioned water liquid merge, and relative density is 1.18～1.20 when being concentrated into 60 ℃, add ethanol and make that to contain alcohol amount be 60%, add 40% sodium hydroxide solution and regulate pH to 6.0～7.0, standing over night is got the supernatant decompression recycling ethanol to there not being the alcohol flavor, merge with above-mentioned distillate, add ethyl hydroxybenzoate 0.5g, adding water to total amount is 1000ml, and regulates pH value to 4.0～6.0, stir evenly, leave standstill, filter embedding, sterilization, promptly.
6. be used for the treatment of application in the medicine of hemorrhoid according to claim 1 or 2 described Chinese medicine compositions in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101597759A CN1931287B (en) | 2005-10-08 | 2006-10-08 | Chinese medicine composition for treating piles and its preparation process |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510105933 | 2005-10-08 | ||
| CN200510105933.8 | 2005-10-08 | ||
| CN2006101597759A CN1931287B (en) | 2005-10-08 | 2006-10-08 | Chinese medicine composition for treating piles and its preparation process |
Publications (2)
| Publication Number | Publication Date |
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| CN1931287A CN1931287A (en) | 2007-03-21 |
| CN1931287B true CN1931287B (en) | 2011-06-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2006101597759A Expired - Fee Related CN1931287B (en) | 2005-10-08 | 2006-10-08 | Chinese medicine composition for treating piles and its preparation process |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1247075A (en) * | 1998-09-09 | 2000-03-15 | 王奉炳 | Chinese patent medicine for treating piles |
| CN1258527A (en) * | 1998-12-30 | 2000-07-05 | 苑子毅 | Fast-acting piles-treating Chinese medicine preparation |
-
2006
- 2006-10-08 CN CN2006101597759A patent/CN1931287B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1247075A (en) * | 1998-09-09 | 2000-03-15 | 王奉炳 | Chinese patent medicine for treating piles |
| CN1258527A (en) * | 1998-12-30 | 2000-07-05 | 苑子毅 | Fast-acting piles-treating Chinese medicine preparation |
Non-Patent Citations (2)
| Title |
|---|
| 钟希文等.中医药治疗痔疮的研究概述.中医药学刊.2006,24(5), * |
| 顾兴平等.中医治疗痔疾临床研究.时珍国药研究.1998,9(1), * |
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| CN1931287A (en) | 2007-03-21 |
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