CN101953949B - Chinese medicinal composition for treating allergic rhinitis - Google Patents
Chinese medicinal composition for treating allergic rhinitis Download PDFInfo
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- CN101953949B CN101953949B CN2010102276959A CN201010227695A CN101953949B CN 101953949 B CN101953949 B CN 101953949B CN 2010102276959 A CN2010102276959 A CN 2010102276959A CN 201010227695 A CN201010227695 A CN 201010227695A CN 101953949 B CN101953949 B CN 101953949B
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Abstract
The invention discloses a Chinese medicinal composition for treating allergic rhinitis, which is prepared from the following raw materials: caulis perllae, great burdock achene, chrysanthemum, belvedere fruit, tribulus terrestris, almond, gypsum, siberian cocklour fruit, biond magnolia, simpleleaf shrub chastetree fruit, dark plum fruit, raw liquoric root, Chinese data and processed ephedra herb.The Chinese medicinal composition has the excellent effect of treating the allergic rhinitis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition of treatment of allergic rhinitis.
Background technology
Allergic rhinitis (allergic rhinitis) claim allergic rhinitis again, is the allergic disease of nasal membrane, and can causes multiple complications.Allergic rhinitis do not have sex difference in morbidity.Its morbidity and inherited genetic factors, environmental factors are relevant with allergenic exposure.Sneeze, nose are overworked, watery nasal discharge and nasal obstruction are modal four big symptoms.
The Therapeutic Method of western medicine mainly contains at present: specific active immunotherapy (also claiming desensitization treatment), non-specific treatment (antihistamine drug, glucocorticoid suction, topical antihistamine thing) two big class methods, though the misery of reduction of patient to a certain extent, but still have that effect is not ideal enough, patient's easy problem such as outbreak repeatedly still.Under the guidance of tcm theory, by a large amount of clinical practices, we sum up and have found this effective Chinese medicinal composition preparation.
Summary of the invention
One object of the present invention is to disclose a kind of Chinese medicine composition of treatment of allergic rhinitis;
Another object of the present invention is to disclose a kind of preparation method of Chinese medicine composition of treatment of allergic rhinitis.
The present invention seeks to be achieved through the following technical solutions:
The Chinese medicine composition of a kind of treatment of allergic rhinitis of the present invention is to be made by the crude drug of following weight ratio:
The Chinese medicine composition of above-mentioned treatment of allergic rhinitis, preferably make by the crude drug of following weight ratio:
The Chinese medicine composition of above-mentioned treatment of allergic rhinitis, preferably make by the crude drug of following weight ratio:
The Chinese medicine composition of above-mentioned treatment of allergic rhinitis, preferably make by the crude drug of following weight ratio:
The Chinese medicine composition of above-mentioned treatment of allergic rhinitis, preferably make by the crude drug of following weight ratio:
Above-mentioned each raw material of Chinese medicine medicine all can be replaced by the proximate medicine of selection function from " Chinese ministry standard ", " pharmacopeia " or " Chinese medicine dictionary " etc.
The present invention also provides the preparation method of the Chinese medicinal composition preparation of above-mentioned treatment of allergic rhinitis, this method is: the above-mentioned raw materials medicine adds the pharmacy acceptable auxiliary according to the above ratio and makes the acceptable any conventional dosage form of pharmaceutics after conventional process is extracted, comprise capsule, tablet, granule, gel, slow releasing agent, oral liquid or drop pill; Described common process method comprises water extraction or alcohol extraction or first water extraction water extraction again after alcohol extraction or the first alcohol extraction again, and it is further active constituent-enriched to cross macroporous resin column after above-mentioned conventional the extraction;
Above-mentioned common process water extracting method can for: each 4-20 doubly measures, and extracts 1-3 hour at every turn 1-4 time;
Above-mentioned common process alcohol extraction method can for: 30-80% ethanol, 4-15 doubly measured, extract respectively 1-3 hour;
Described macroporous resin column method excessively is: extracting solution filters, and filtrate is passed through macroporous resin, first ethanol elution with 4-6 times of water gaging or 20% following concentration, eluent is abandoned or adopted, and reuse adds 1-10 times of eluting of 50-80% ethanol, collects eluent, decompression recycling ethanol gets the purification extracting solution to there not being the alcohol flavor.
Described pharmacy acceptable auxiliary is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Can loose wind, clear the nasal passage of Fructus Xanthii, Flos Magnoliae, Fructus Viticis in the present composition prescription; Lung-QI connecting with the nose, Caulis Perillae, Semen Armeniacae Amarum master dispersing and lowering lung-QI, sensible to help the nose key; Ailment said due to cold or exposure often can be invaded throat, eyes etc. simultaneously and locate last, and the appearance pharynx is overworked, eyes are rubescent itches, so go into throat and binocular with Fructus Arctii, Flos Chrysanthemi; Overworked key medicine till the Fructus Kochiae, the Fructus Tribuli, it is overworked to drive away nose; Allergic rhinitis mostly is lung system heat, event Gypsum Fibrosum heat clearing away; Fructus Mume, system Herba Ephedrae have similar antihistamine effect through the modern study proof, can drive away symptoms such as rhinocnesmus, sneeze; Radix Glycyrrhizae, Fructus Jujubae coordinating the actions of various ingredients in a prescription.Confirm that through clinical trial treatment of allergic rhinitis total effective rate of the present invention reaches 93.33%, the patient takes medicine and 2 weeks got final product doing well,improving, and finds no side effect and safety in the drug administration process, is easy to promote.
Following experimental example and embodiment further specify the present invention.
The therapeutic evaluation of experimental example 1 " prescriptions of Chinese medicine of allergic rhinitis " treatment of allergic rhinitis
1. physical data
Sick 82 examples of allergic rhinitis that traditional Chinese medical science hall traditional chinese medical science clinic of Beijing University of Chinese Medicine accepts for medical treatment, male's 46 examples wherein, women's 36 examples, age, the course of disease was the longest 8 years between 18～55 years old, and is the shortest 20 days, be divided into test group and matched group at random, two groups of ages, sex no significant difference.
2. medicine is formed and usage
2.1 trial drug
Prescriptions of Chinese medicine water decoction of the present invention, medicine is formed: Caulis Perillae 15g Fructus Arctii 15g Flos Chrysanthemi 15g Fructus Kochiae 15g Fructus Tribuli 15g Semen Armeniacae Amarum 15g Gypsum Fibrosum 15g Fructus Xanthii 15g Flos Magnoliae 15g Fructus Viticis 15g Fructus Mume 15g Radix Glycyrrhizae 15g Fructus Jujubae 15g system Herba Ephedrae 12g.
2.2 control drug
XINQIN granule (the wide and pharmaceutical Co. Ltd's production of Sichuan Province's Cortex et Radix Polygalae, lot number 010113) is made up of kinds of traditional Chinese medicines materials such as Herba Asari, Radix Scutellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Herba Schizonepetae, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Fructus Xanthii, Rhizoma Acori Graminei.
3. therapeutic scheme
The treatment group: trial drug is decocted in water for oral dose, twice of every day.
Matched group: take the XINQIN granule, 3 times/d, each 1 bag (5g), warm boiled water.
The course of treatment: treatment is 14 days with matched group the course of treatment.
4. observation of curative effect
4.1 efficacy assessment standard
According to hals,Nasen und Ohrenheilkunde branch of Chinese Medical Association " principle of diagnosis and treatment of allergic rhinitis and suggested design (2004, Lanzhou) ",, keep the score and assessment method according to sings and symptoms (sneeze, watery nasal discharge, nasal obstruction, nose are overworked etc.) the evaluation curative effect of keeping the score:
Produce effects: treatment back primary symptom integration reduces 〉=66% before the treatment;
Effectively: treatment back primary symptom integration reduces 65%～26% before the treatment;
Invalid: treatment back primary symptom integration reduces≤25% before the treatment.
4.2 statistical procedures method
Utilization spss.13.0 statistical software carries out statistical analysis, adopts X
2Check.
5. result
Treatment relatively sees the following form with the matched group clinical efficacy.
Treatment is compared with the matched group clinical efficacy
The clinical efficacy of treatment and treatment of control group allergic rhinitis compares, through X
2Check, difference has significance meaning (P＜0.05), and the curative effect of treatment group is better than matched group.
Following embodiment does further explanation to the present invention, but does not constitute restriction of the present invention.
The specific embodiment
Embodiment 1:
More than decoct with water three times, 1 hour for the first time, each 45 minutes collecting decoction of second and third time, filter, filtrate is concentrated into about 300ml, adds ethanol 300ml, stir evenly, left standstill 12 hours, filter, reclaim ethanol and be concentrated into about 200ml, add the Icing Sugar mixing, make granule, drying, make mixing, promptly get granule.
Embodiment 2:
Above-mentioned raw materials medicated powder is broken into fine powder, sieves, and mixing promptly gets powder.
Embodiment 3:
More than decoct with water three times, add 5 times of water gagings at every turn, 1 hour for the first time, each 45 minutes collecting decoction of second and third time, filter, filtrate is concentrated into about 300ml, adds ethanol 300ml, stirs evenly, left standstill 12 hours, and filtered, reclaim ethanol and be concentrated into about 200ml, make capsule through conventional technology.
Embodiment 4:
Make oral liquid through conventional technology.
Embodiment 5:
Make soft capsule through conventional technology.
Claims (6)
1. the Chinese medicine composition of a treatment of allergic rhinitis is characterized in that said composition is to be made by the crude drug of following weight ratio:
2. Chinese medicine composition as claimed in claim 1 is characterized in that said composition is to be made by the crude drug of following weight ratio:
3. Chinese medicine composition as claimed in claim 2 is characterized in that said composition is to be made by the crude drug of following weight ratio:
4. Chinese medicine composition as claimed in claim 1 is characterized in that said composition is to be made by the crude drug of following weight ratio:
5. Chinese medicine composition as claimed in claim 1 is characterized in that said composition is to be made by the crude drug of following weight ratio:
6. as described any one Chinese medicine composition of claim 1-5, it is characterized in that said composition adds the pharmacy adjuvant and makes capsule, tablet, granule, gel or oral liquid after conventional process is extracted.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102276959A CN101953949B (en) | 2009-07-16 | 2010-07-14 | Chinese medicinal composition for treating allergic rhinitis |
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| CN200910150178.3 | 2009-07-16 | ||
| CN200910150178 | 2009-07-16 | ||
| CN2010102276959A CN101953949B (en) | 2009-07-16 | 2010-07-14 | Chinese medicinal composition for treating allergic rhinitis |
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| CN101953949A CN101953949A (en) | 2011-01-26 |
| CN101953949B true CN101953949B (en) | 2011-11-16 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977376A (en) * | 2014-05-19 | 2014-08-13 | 青岛市城阳区人民医院 | Traditional Chinese medicine medicament for treating allergic rhinitis and preparation method thereof |
| CN107095904A (en) * | 2017-04-10 | 2017-08-29 | 苏州九真医药科技有限公司 | Treat the Chinese medicine preparation of rhinitis |
| CN107137558A (en) * | 2017-05-25 | 2017-09-08 | 中国中医科学院广安门医院 | A kind of composition for treating allergic rhinitis |
| CN109276439B (en) * | 2018-12-12 | 2019-12-17 | 南通市第一人民医院 | fumigation device of allergic rhinitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915333A (en) * | 2006-08-25 | 2007-02-21 | 袁爱仙 | Medication of steaming nose for treating rhinitis in pachismus type, and preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915333A (en) * | 2006-08-25 | 2007-02-21 | 袁爱仙 | Medication of steaming nose for treating rhinitis in pachismus type, and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 李洪等.鼻炎汤治疗鼻炎、鼻窦炎.《新中医》.2007,第39卷(第03期), * |
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| CN101953949A (en) | 2011-01-26 |
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