CN108938473A - A kind of herbaceous toothpaste and its preparation method and application for preventing and treating oral inflammation - Google Patents
A kind of herbaceous toothpaste and its preparation method and application for preventing and treating oral inflammation Download PDFInfo
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- CN108938473A CN108938473A CN201811091756.6A CN201811091756A CN108938473A CN 108938473 A CN108938473 A CN 108938473A CN 201811091756 A CN201811091756 A CN 201811091756A CN 108938473 A CN108938473 A CN 108938473A
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- herbaceous toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention belongs to sanitary product technical fields, specifically disclose a kind of herbaceous toothpaste and its preparation method and application for preventing and treating oral inflammation.The herbaceous toothpaste, is calculated in percentage by weight, includes fermentation cordyceps 1-2%, Cichoric acid 6-8%, glycyrrhetinic acid 0.5-1.5%, calcium activated 20-30%, anionic surfactant 1-3%, thickener 2-5%, surplus is water.The herbaceous toothpaste has heat-clearing, relieves the pain, is anti-inflammatory, is antiviral, antibacterial, antiallergy resistance state, and without the additives such as preservative, rubbing agent, adhesive binding agents, alcohol, children and at can be used per capita, safety is without side-effects.It is handled when prepared by the herbaceous toothpaste using microemulsified, thermodynamic stability is good, and placing for a long time will not be layered and be demulsified.The herbaceous toothpaste is while solving oral hygiene, moreover it is possible to make the anti-treating dental ulcer of consumer, gingival swelling and pain, gingivitis, periodontitis etc., be conducive to marketing.
Description
Technical field
The invention belongs to sanitary product technical fields, specifically, being related to a kind of draft tooth for preventing and treating oral inflammation
Cream and its preparation method and application.
Background technique
Toothpaste is a kind of common daily necessities, for cleaning oral cavity, tooth-whitening or preventing odontopathy.Closely
Come, with the continuous improvement of people's living standards, health perception is also constantly enhancing, dental care products also proposed more
High requirement.Consumer is not concerned only with oral cleaning effect itself when choosing toothpaste, also favor prevention and treatment mouth disease etc. other
Effect.
Gingivitis, periodontitis and canker sore etc. are all current most commonly seen mouth diseases, and 90% adult has
Different degrees of oral problem, therefore, the importance of oral health are also recognized by crowd therewith.Gingivitis shows as gum and goes out
Blood, red and swollen, distending pain continue development and invade sclerous tissues, generate periodontitis, this due to mechanical irritation when brushing teeth or feeding
Gum under inflammatory conditions is just easy to bleeding.Recurrent oral ulceration has very close relationship with immune first.Some trouble
Person shows as immune deficiency, and some patients then show as autoimmune response, that is, due to various factors, keep human body normal
Immune system generates immune reflection to autologous tissue's antigen, and causes disorganization and fall ill.It is followed by related with heredity
System, in clinic, the morbidity of recurrent oral ulceration has apparent Family inherited inclination, we usually see, one side of parent or
If suffering from recurrent oral ulceration in many ways, then, their children are just easier illness than common people.In addition, recurrent oral
The breaking-out of ulcer, it is usually also related with some diseases or symptom, such as disease of digestive system gastric ulcer, duodenal ulcer, slowly
Property or metastatic hepatitis, colitis etc., in addition anaemia, partial eclipse, indigestion, diarrhea, generate heat, sleep insufficiency, over fatigue, essence
Refreshing nervous, operating pressure is big, the change of menstrual cycle etc..As the active of one or more factors, alternating, overlapping occur as soon as
Immunity of organisms decline, immunologic function disorder have also resulted in the frequent breaking-out of recurrent oral ulceration.
It is usually to add that effective drug can prevent and treat bacterium or virus causes in toothpaste in existing formulation of tooth-paste
Various mouth diseases.Antibiotic can effective antibacterial, but side effect is larger, and antibiotic is used for a long time and is likely to result in flora mistake
It adjusts, generates the adverse consequences such as drug resistance, therefore those skilled in the art need to research and develop one kind with antiinflammatory and bacteriostatic functions, and without pair
The toothpaste of effect.
Summary of the invention
The object of the invention is to provide a kind of grass for preventing and treating oral inflammation to overcome the shortcomings of existing Chinese medicine toothpaste
This toothpaste and its preparation method and application is usually to add effective drug in toothpaste to prevent and control to solve existing toothpaste
When treating various mouth diseases caused by bacterium or virus, the imbalance of people's oral cavity flora may cause, after generation drug resistance etc. is bad
The problem of drug side-effect of fruit.
In order to solve the above-mentioned technical problem, the present invention is addressed by following technical proposals:
It is a kind of prevent and treat oral inflammation herbaceous toothpaste, calculate in percentage by weight, comprising fermentation cordyceps 1-2%,
Cichoric acid 6-8%, glycyrrhetinic acid 0.5-1.5%, calcium activated 20-30%, anionic surfactant 1-3%, thickener 2-
5%, surplus is water.
It include fermentation cordyceps 1.5%, Cichoric acid 7%, glycyrrhetinic acid preferably, calculating in percentage by weight
1%, calcium activated 25%, anionic surfactant 2%, thickener 3.5%, surplus are water.
Preferably, the anionic surfactant is sodium methyl cocoyl taurate, sodium lauroyl glutamate, rouge
One or more of mixtures of fatty acid methyl esters sodium sulfonate.
Sodium methyl cocoyl taurate is a kind of new amino acid type surfactant, by natural fatty acid with
N-methyltaurine sodium is condensed, it makes foaming abundancy, exquisiteness, stabilization, knot containing hydrophilic amino acid under the conditions of wide pH value
Structure is very small to skin irritation.
Sodium lauroyl glutamate is that amino acid type surfactant not only has good readily degradable, antibiotic property, safety
Property, no anaphylaxis.And since its special structure determines that it has good water solubility, salt-resistance as amphoteric surfactant
There are many excellent properties by force and with pH responsiveness.
Methyl sodiosul foaliphatate is the third generation surface-active of putative substitution sodium alkyl sulfonate (LAS) in the world
Agent, since its is safe and non-toxic, resistance to hard water is strong, fully biodegradable, is known as really environmentally protective surfactant.
Preferably, the thickener is sodium carboxymethylcellulose, the one or more of carragheen, colloidality aluminium-magnesium silicate are mixed
Close object.
The thickener is used to improve and increase the viscosity of food, keeps the color of fluidised form food, jelly food
And stability, improve food physical behavior, and food can be made to have and lubricate agreeable to the taste feeling.The viscosity of food can be improved in thickener
Or gel is formed, to change the physical behavior of food, the glutinous profit of food, suitable mouthfeel are assigned, and have emulsification, stabilization concurrently or make
In the effect of suspended state.The thickening efficiency of the thickener is high, and workable pH range is big.It is widely used.
Fermentation cordyceps, Chinese patent drug name.Fermentation cordyceps are to separate from the fresh cordyceps sinensis in Qinghai in the application
Asexual generation -- the Chinese beam of obtained section ergot fungus cordyceps sinensis [Cordyceps sinensis (Berk.) Sae.]
Silk spore (Synnematum sinense Yin et Shen sp.now) strain is through mycelial drying obtained by liquid fermentation and culture
Powder.
Fermentation cordyceps mainly contain ucleosides and base, amino acid, sterols, polysaccharide etc. in the application.Ucleosides
Compound is one of principle active component of fermentation cordyceps, is water soluble ingredient, has and improves immune, anti-oxidant, anti-swell
The therapeutic effect of tumor and anticancer.Mannitol is a kind of flavor components, is present in the fructification of general mushroom, is certain Cordyceps Militaris
One of powder quality control index.Mannitol is not metabolized in vivo, is very lacked in renal tubule after glomerular filtration by reabsorption,
With osmotic diuresis effect.
Ergosterol is the distinctive ingredient of fungal organism film, is the important precursor substance of vitamin D 2, has important medicine
With value.In cordyceps sinensis, sterols exists in form that is free and combining.Polysaccharide be the essential ingredient of each organism with
Every function that sustains life has close connection.Cordyceps sinensis polysaccharide, which has, improves oral immunisation, the oxidation resistant protection of enhancing.
Cichoric acid is a kind of water-soluble phenolic compounds extracted from the dry herb of compositae plant witloof, have it is anti-inflammatory,
Enhancing immune function and the effect induced cell apoptosis, and hyaluronidase can be inhibited, protect collagen from can lead to drop
The influence of the free radical of solution.
Cichoric acid can also have by stimulating the immune system of body to enhance body to the resistance of bacterium and virus infection
There is antibiotic, be used for Reduce allergy symptom, and for a long time for treating skin infection.
Cichoric acid has enhancing immune function, anti-inflammatory effect, and can inhibit hyaluronidase, protect collagen III from
It can lead to the influence of the free radical of degradation.Nearest research inhibits HIV-1 and HIV-1 integrase it is also show that Cichoric acid has
Effect.
The effects of glycyrrhetinic acid is soluble in the white crystals or crystalline powder of ethyl alcohol, chloroform, inhibits bacterial reproduction, can
The immune function for adjusting skin, enhances the disease resistance of skin, diminishes inflammation, pre- hypo-allergenic, cleaning skin, while can also release
The toxic side effect of toothpaste and other extraneous factors to mouth skin.
Another object of the present invention additionally provides the preparation method of the herbaceous toothpaste of above-mentioned prevention and treatment oral inflammation, including step
It is as follows:
1) fermentation cordyceps, Cichoric acid, glycyrrhetinic acid, calcium activated, anionic surfactant are uniformly mixed, then
Water is slowly added dropwise into system and carries out microemulsified processing, obtains O/W type lotion.
2) then the O/W type lotion that thickener and step 1) obtain is placed in pressurized tank, is -0.05MPa in vacuum degree
High-speed stirred 10-20min under conditions of~-0.08MPa, speed of agitator are 2000~2500rpm/min.
3) it finally, toothpaste is qualified through examining, packs, storage.
Preferably, microemulsified treatment temperature described in step 1) is 10-20 DEG C；The partial size of the O/W type lotion is 8-
150nm。
The herbaceous toothpaste that further object of the present invention is to provide above-mentioned prevention and treatment oral inflammation is preventing and treating mouth disease
In application.
Preferably, the mouth disease is canker sore, any in gingival swelling and pain, gingivitis, periodontitis.
Compared with prior art, the present invention can be obtained including following technical effect:
It 1) include fermentation cordyceps, Cichoric acid and sweet in the herbaceous toothpaste of prevention and treatment oral inflammation provided by the invention
Careless pavilion acid plays heat-clearing, relieves the pain, is anti-inflammatory, is antiviral, antibacterial, antiallergy resistance state, the effect to reach the strong gum of permanent tooth
Fruit.
The herbaceous toothpaste of the prevention and treatment oral inflammation of the application, adds without preservative, rubbing agent, adhesive binding agents, alcohol etc.
Add agent, fermentation cordyceps, Cichoric acid and glycyrrhetinic acid are absorbed by the through taste of mucous membrane of mouth, there is sterilization, antibacterial, analgesic
Effect, can salubrious implication, alleviate canker sore, conserve gum, effectively eliminate and prevent gum red and swollen and bleeding, children and at
It can be used per capita, safety is without side-effects.
2) calcium activated can improve enamel density, enhance toothpaste cleaning capacity, adjust toothpaste pH value, keep it warmer to skin
With, be conducive to skin absorb；Therefore, it is provided by the invention prevention and treatment oral inflammation herbaceous toothpaste while solving oral hygiene,
It can also make the anti-treating dental ulcer of consumer, gingival swelling and pain, gingivitis, periodontitis etc..
Quick using the herbaceous toothpaste of the application, consumer can see effect using 2-3 days.
3) it is handled when the herbaceous toothpaste preparation of prevention and treatment oral inflammation provided by the present application using microemulsified, obtains O/W type cream
Liquid, interfacial tension is low, small in the partial size of 20mN.m-1 or so, microemulsion, and partial size is between 8-150nm, thermodynamic stability
Good, placing for a long time will not be layered and be demulsified.
Certainly, implementing any of the products of the present invention must be not necessarily required to reach all the above technical effect simultaneously.
Specific embodiment
Following embodiment carrys out the embodiment that the present invention will be described in detail, and to the present invention, how applied technology method is solved whereby
Certainly technical problem and reaches the realization process of technical effect and can fully understand and implement.
Raw material use herein, equipment are the common raw material, equipment of this field, are all from city unless otherwise noted
Sell product.Method use herein is unless otherwise noted the conventional method of this field.
Embodiment 1
A kind of herbaceous toothpaste for preventing and treating oral inflammation, is calculated, in percentage by weight by fermentation cordyceps 1.5%, chrysanthemum
Lettuce acid 7%, glycyrrhetinic acid 1%, calcium activated 25%, sodium methyl cocoyl taurate 2%, sodium carboxymethylcellulose 3.5%, it is remaining
Amount is that water forms.
A kind of preparation method of the herbaceous toothpaste of prevention and treatment oral inflammation of the present embodiment, steps are as follows:
1) it is weighed according to weight percent, by fermentation cordyceps, Cichoric acid, glycyrrhetinic acid, calcium activated, anionic surface
Activating agent is uniformly mixed, and water is then slowly added dropwise into system and carries out microemulsified processing, obtains O/W type lotion.
The microemulsified treatment temperature is 15 DEG C；The partial size of the O/W type lotion is 8-100nm.
2) then the O/W type lotion that thickener and step 1) obtain is placed in pressurized tank, is -0.05MPa in vacuum degree
High-speed stirred 15min under conditions of~-0.08MPa, speed of agitator are 2200~2300rpm/min.
3) it finally, toothpaste is qualified through examining, packs, storage.
Embodiment 2
The herbaceous toothpaste formula of the prevention and treatment oral inflammation of the present embodiment is similar to Example 1, and difference is only that: according to weight
It measures percentage to calculate, by fermentation cordyceps 1%, Cichoric acid 6%, glycyrrhetinic acid 0.5%, calcium activated 20%, lauroyl paddy ammonia
Sour sodium 1%, carragheen 2%, surplus are water composition.
The preparation method of the herbaceous toothpaste of the prevention and treatment oral inflammation of the present embodiment, similar to Example 1, difference only exists
In:
The microemulsified treatment temperature is 10 DEG C in step 1)；The partial size of the O/W type lotion is 20-150nm.
Step 2) high speed mixing time is 10min, and speed of agitator is 2000~2200rpm/min.
Embodiment 3
The herbaceous toothpaste formula of the prevention and treatment oral inflammation of the present embodiment is similar to Example 1, and difference is only that: according to weight
It measures percentage to calculate, by fermentation cordyceps 2%, Cichoric acid 8%, glycyrrhetinic acid 1.5%, calcium activated 30%, fatty acid methyl ester
Sodium sulfonate 3%, colloidality aluminium-magnesium silicate 5%, surplus are water composition.
The preparation method of the herbaceous toothpaste of the prevention and treatment oral inflammation of the present embodiment is similar to Example 1, and difference is only that:
The microemulsified treatment temperature is 20 DEG C in step 1)；The partial size of the O/W type lotion is 8-100nm.
Step 2) high speed mixing time is 20min, and speed of agitator is 2300~2500rpm/min.
The herbaceous toothpaste of prevention and treatment oral inflammation obtained by the present embodiment 1-3 is tested for the property, and quality meets national correlation
Standard.Confirmed through clinical trial, gained finished product can prevent and treat mouth disease for example canker sore, gingival swelling and pain, gingivitis,
Periodontitis, good absorption effect, it is quick, and can deep clean tooth holding dental health.It is clinic with 1 gained finished product of embodiment
Test specimen carries out clinical test, specific as follows:
Clinical use efficacy assessments
Selection 80 has the patient of the mouth disease of periodontitis, gingivitis or canker sore, and 12~60 one full year of life of age uses
Herbaceous toothpaste prepared by the embodiment of the present application 1, daily early, evening respectively brush teeth once, and horizontal trembling method is brushed teeth, and the time is 3-5 minutes,
The lotion of toothpaste used is about 0.8-1.5cm.After being used continuously 2 weeks, effective percentage is up to 100%, and gingivitis patients gingiva color is just
Often and gum is full, and gum disappears, has no adverse reaction without swelling bleeding, canker sore patient pain, not multiple in 2 months
Hair.Illustrate that the herbaceous toothpaste of the application all has apparent preventive and therapeutic effect to periodontitis, gingivitis and canker sore.
Comparative example 4
The herbaceous toothpaste formula of this comparative example 4 is similar to Example 1, and difference is only that: according to weight percent
It calculates, includes fermentation cordyceps 0.5%, Cichoric acid 4%, glycyrrhetinic acid 0.3%, calcium activated 15%, preparation method and reality
It is identical to apply example 1.
Clinical case:
Qian, female, 36 years old, canker sore often recurred, and was repeatedly treated easy to recur.Daily early, evening respectively brushes teeth once,
Horizontal trembling method is brushed teeth, and the time is 3-5 minutes, and the lotion of toothpaste used is about 0.8-1.5cm.Sooner or later comparative example 4 is used
Herbaceous toothpaste slightly improve after a week, continue to use and cure after a week, recurred 1 time in patient 2 months.
Comparative example 5
The herbaceous toothpaste formula of this comparative example is similar to Example 1, and difference is only that:
It calculates in percentage by weight, includes fermentation cordyceps 3%, Cichoric acid 10%, glycyrrhetinic acid 3%, calcium activated
45%, preparation method is same as Example 1.
Clinical case:
Chen 67 years old, suffers from periodontitis, bleeding gums early period, and daily early, evening respectively brushes teeth once, and horizontal trembling method is brushed teeth, when
Between be 3-5 minutes, the lotion of toothpaste used is about 0.8-1.5cm.Sooner or later using after herbaceous toothpaste 2 days of comparative example 5 because
Toothpaste mouthfeel is not good enough, has burning sensation, toothpaste alkalinity higher, stops using.
The herbaceous toothpaste volume advantageous effects of the prevention and treatment oral inflammation of the embodiment of the present application 1-3 preparation are as follows:
It 1) include fermentation cordyceps, chrysanthemum in the herbaceous toothpaste for the prevention and treatment oral inflammation that the embodiment of the present application 1-3 is provided
Lettuce acid and glycyrrhetinic acid, play heat-clearing, relieve the pain, be anti-inflammatory, is antiviral, antibacterial, antiallergy resistance state, to reaching the strong tooth of permanent tooth
The effect of gum.
The herbaceous toothpaste of the prevention and treatment oral inflammation of the embodiment of the present application 1-3 preparation, it is viscous without preservative, rubbing agent, colloidality
The additives such as mixture, alcohol, fermentation cordyceps, Cichoric acid and glycyrrhetinic acid are absorbed by the through taste of mucous membrane of mouth, are killed
Bacterium, the effect of antibacterial, analgesic, can salubrious implication, anti-treating dental ulcer conserves gum, effectively eliminates and prevent gum red and swollen
And bleeding, children and at can be used per capita, safety is without side-effects.
2) it is close to improve enamel for the calcium activated of the herbaceous toothpaste of the prevention and treatment oral inflammation of the embodiment of the present application 1-3 preparation
Degree enhances toothpaste cleaning capacity, adjusts toothpaste pH value, makes it to skin milder, is conducive to skin and absorbs；Therefore, the present invention mentions
The herbaceous toothpaste of the prevention and treatment oral inflammation of confession is while solving oral hygiene, moreover it is possible to make the anti-treating dental ulcer of consumer, tooth
Swelling and pain, gingivitis, periodontitis etc..
3) herbaceous toothpaste of the prevention and treatment oral inflammation of the embodiment of the present application 1-3 preparation is handled using microemulsified, obtains O/W type
Lotion, interfacial tension is low, small in the partial size of 20mN.m-1 or so, microemulsion, and partial size is between 8-150nm, Thermodynamically stable
Property it is good, for a long time place will not be layered and be demulsified.
The application does not enumerate, the claim of this application herein there is also other a variety of enforceable technical solutions
In claimed technical solution all can be implemented.
The content being not described in detail in present specification belongs to the common knowledge of those skilled in the art.
It should also be noted that, the terms "include", "comprise" or its any other variant are intended to nonexcludability
Include, so that commodity or system including a series of elements not only include those elements, but also including not clear
The other element listed, or further include for this commodity or the intrinsic element of system.In the feelings not limited more
Under condition, the element that is limited by sentence "including a ...", it is not excluded that in the commodity or system for including the element also
There are other identical elements.
Several preferred embodiments of the invention have shown and described in above description, but as previously described, it should be understood that the present invention
Be not limited to forms disclosed herein, should not be regarded as an exclusion of other examples, and can be used for various other combinations,
Modification and environment, and the above teachings or related fields of technology or knowledge can be passed through within that scope of the inventive concept describe herein
It is modified.And changes and modifications made by those skilled in the art do not depart from the spirit and scope of the present invention, then it all should be in this hair
In the protection scope of bright appended claims.
Claims (8)
1. a kind of herbaceous toothpaste for preventing and treating oral inflammation, which is characterized in that calculate in percentage by weight, include ferment cordyceps sinensis bacterium
Powder 1-2%, Cichoric acid 6-8%, glycyrrhetinic acid 0.5-1.5%, calcium activated 20-30%, anionic surfactant 1-3%, increase
Thick dose of 2-5%, surplus are water.
2. a kind of herbaceous toothpaste for preventing and treating oral inflammation as described in claim 1, which is characterized in that in percentage by weight
It calculates, includes fermentation cordyceps 1.5%, Cichoric acid 7%, glycyrrhetinic acid 1%, calcium activated 25%, anionic surfactant
2%, thickener 3.5%, surplus are water.
3. a kind of herbaceous toothpaste for preventing and treating oral inflammation as claimed in claim 1 or 2, which is characterized in that the anion table
Face activating agent is sodium methyl cocoyl taurate, the one or more of sodium lauroyl glutamate, methyl sodiosul foaliphatate are mixed
Close object.
4. a kind of herbaceous toothpaste for preventing and treating oral inflammation as claimed in claim 1 or 2, which is characterized in that the thickener is
Sodium carboxymethylcellulose, carragheen, colloidality aluminium-magnesium silicate one or more of mixtures.
5. the preparation method of the herbaceous toothpaste of the described in any item prevention and treatment oral inflammations of Claims 1-4, which is characterized in that packet
Include that steps are as follows:
1) fermentation cordyceps, Cichoric acid, glycyrrhetinic acid, calcium activated, anionic surfactant are uniformly mixed, then to body
Water is slowly added dropwise in system and carries out microemulsified processing, obtains O/W type lotion；
2) then the O/W type lotion that thickener and step 1) obtain is placed in pressurized tank, vacuum degree be -0.05MPa~-
High-speed stirred 10-20min under conditions of 0.08MPa, speed of agitator are 2000~2500rpm/min；
3) it finally, toothpaste is qualified through examining, packs, storage.
6. the preparation method of the herbaceous toothpaste of prevention and treatment oral inflammation as claimed in claim 5, which is characterized in that institute in step 1)
Stating microemulsified treatment temperature is 10-20 DEG C；The partial size of the O/W type lotion is 8-150nm.
7. the herbaceous toothpaste of prevention and treatment oral inflammation as claimed in any one of claims 1 to 6 is in preventing and treating mouth disease
Using.
8. application as claimed in claim 8, which is characterized in that the mouth disease is canker sore, gingival swelling and pain, gum
It is any in scorching, periodontitis.
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Application publication date: 20181207 |