CN108379106A - A kind of GUF licorice active components composition and the GUF Radix Glycyrrhizae toothpaste comprising the composition - Google Patents
A kind of GUF licorice active components composition and the GUF Radix Glycyrrhizae toothpaste comprising the composition Download PDFInfo
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- CN108379106A CN108379106A CN201810393156.9A CN201810393156A CN108379106A CN 108379106 A CN108379106 A CN 108379106A CN 201810393156 A CN201810393156 A CN 201810393156A CN 108379106 A CN108379106 A CN 108379106A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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Abstract
The invention belongs to toothpaste manufacture technology fields, a kind of GUF Radix Glycyrrhizae toothpaste more particularly to GUF licorice active components composition and comprising the composition, GUF licorice active components composition of the invention are (0.5 1) in mass ratio by dipotassium glycyrrhizinate, ammonium glycyrrhetate, disodium glycyrrhizinate and stearyl alcohol glycyrrhetin acid esters:(0.5‑1):(0.1‑1):(0.1 1) compound, and GUF Radix Glycyrrhizae toothpaste of the invention is composed of the following raw materials by weight：0 0.2 parts of 0.01 10 parts of GUF licorice active components composition, 30 80 parts of moisturizer, 10 30 parts of rubbing agent, 0.1 10 parts of foaming agent, 0.1 15 parts of thickener, 02 parts of aromatic, 01 parts of pH buffer and pigment.The toothpaste that the present invention contains GUF licorice active component compositions passes through reasonable compatibility, has and eliminates oral inflammation, inhibits the healthcare function of oral bacteria.
Description
Technical field
The invention belongs to toothpaste manufacture technology fields, and in particular to a kind of GUF licorice active components composition and include this
The GUF Radix Glycyrrhizae toothpaste of composition.
Background technology
With being increasingly enhanced for consumer healthcare's consciousness, have except basic function requiring toothpaste, it is also proposed that more
Oral health demand, for example auxiliary is prevented or the mouth diseases such as treatment canker sore, anti-inflammatory is antibacterial.It is various on toothpaste market at present
A hundred flowers blossom and demand is also growing day by day for functional product, and wherein Chinese herbal medicine toothpaste is because of its active component content high effect
The features such as notable and high security, firmly gets consumers, so the functional toothpaste containing active ingredient of Chinese herbs becomes current hair
The hot spot of exhibition.
Also have in the prior art using various active ingredient of Chinese herbs as toothpaste ancillary drug, such as pseudo-ginseng toothpaste, Yunnan
Baiyao toothpaste, dendrobium candidum toothpaste, Lamiophlomis rotata toothpaste etc., effect is had nothing in common with each other.Primary efficacy used by such as pseudo-ginseng toothpaste
Ingredient is notoginsenoside, and that there are distributional regions is few for crude drug, and growth cycle length leads to product price height.And Radix Glycyrrhizae is also known as " state
Always ", have invigorate the spleen and benefit qi, be clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription the benefits of, Regional Distribution extensively, price
It is cheap, the effect of its extract carries out high-purity derivative, can be directed to strengthen active constituent is chosen, the perfection with lotion of toothpaste is mediated,
Sweet and refreshing quality of the life can be brought to consumer daily.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of GUF licorice active components of kind and it includes the active ingredients
GUF Radix Glycyrrhizae toothpaste, the GUF Radix Glycyrrhizae toothpaste that method using the present invention is prepared has by reasonable compatibility eliminates stomatitis
Disease inhibits the healthcare function of oral bacteria.
To achieve the goals above, the technical solution adopted in the present invention is：A kind of GUF licorice active components, the GUF
Licorice active component is (0.5- in mass ratio by dipotassium glycyrrhizinate, ammonium glycyrrhetate, disodium glycyrrhizinate and stearyl alcohol glycyrrhetin acid esters
1):(0.5-1):(0.1-1):(0.1-1) is compounded.
GUF licorice active components have antibacterial anti-inflammatory, anti-oxidant, anti-aging, antivirus action.
The present invention also provides a kind of GUF toothpaste, including the GUF licorice active components, the Radix Glycyrrhizae toothpaste is by weight
Number meter, is made of following raw material：0.01-10 parts of GUF licorice active components, 30-80 parts of moisturizer, 10-30 parts of rubbing agent, hair
0-0.2 parts of 0.1-10 parts of infusion, 0.1-15 parts of thickener, 0-2 parts of aromatic, 0-1 parts of pH buffer and pigment.
On the basis of said program, the present invention can also do following improvement.
Preferably, the GUF licorice active components account for the 0.01-10% of the GUF Radix Glycyrrhizaes lotion of toothpaste weight.
Preferably, the GUF licorice active components account for the 0.1-2% of the GUF Radix Glycyrrhizaes lotion of toothpaste weight.
Preferably, the rubbing agent is silica.
Preferably, it counts in parts by weight, the moisturizer is made of following raw material：8-50 parts of sorbierite, 1-10 parts of glycerine,
10-20 parts of 1-5 parts of polyethylene glycol and water.
Preferably, it counts in parts by weight, the thickener is by 0.5-2 parts of cellulose gum and 0.1-2 parts of groups of Chondrus crispus
At.
Preferably, it counts in parts by weight, the foaming agent is by 1-8 parts of sldium lauryl sulfate and Cocoamidopropyl betaine
0.1-2 parts of compositions.
Preferably, it counts in parts by weight, the aromatic is by 0.5-1.5 parts of food flavor and tri-chloro galactose type sugar 0.01-0.3
Part composition.
Preferably, the pH buffer is tetrasodium pyrophosphate.
GUF Radix Glycyrrhizaes toothpaste provided by the invention has the advantage that：Drug effect is wide, the antibacterial, emergency with apparent anti-inflammatory
Analgesic, pre- preventing parodontitis, gingivitis, halitosis, saprodontia, canker sore and other effects, additionally due to Radix Glycyrrhizae Regional Distribution is extensive, price
Cheap feature can be effectively reduced the cost for producing the medicated toothpaste.
Specific implementation mode
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
The Radix Glycyrrhizae used in the embodiment of the present invention, Latin literary fame：Glycyrrhiza uralensis Fisch, with its head
Letter is come to name active constituent in the present invention be GUF licorice active components.Alias：State is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root
Son.Pulse family, Glycyrrhiza perennial herb, root is sturdy with root-like stock, is a kind of help Chinese herbal medicine.To a kind of human body medicine well,
Medicinal part is root and rhizome, and Medicinal Materials Characters root is cylinder, 25~100 centimetres long, 0.6~3.5 centimetre of diameter.Crust is elastic
Differ, surface rufous or taupe brown.Rhizome is cylinder, and there is bud scar on surface, has marrow in the middle part of section.Gas is micro-, sweet and special.
Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..Happiness is dark moist, the low dry climate of the long temperature of sunshine.Radix Glycyrrhizae grows more
In arid, semiarid desert steppe, desert edge and loess hill area, root and root-like stock hyoscine.
With reference to embodiment, the present invention will be further described.Involved data refer to parts by weight in following table, real
The composition for applying GUF licorice active components used in example 1 to embodiment 6 is shown in Table 1, GUF Radix Glycyrrhizae toothpaste constituents in embodiment 1-6
It is shown in Table 2.
1 embodiment GUF licorice active components of table form table
2 embodiment toothpaste of table forms table
The preparation method of embodiment 1-6 is as follows：
Step 1：Mixing in vacuum Manufacturing medicine extract machine is added in sorbierite, glycerine, polyethylene glycol, adds cellulose gum, ripple
Irish moss, laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine, tetrasodium pyrophosphate and silica are sufficiently stirred；
Step 2：The deionized water mixing of water inventory 80wt% is added under vacuum stirring state；
Step 3：With remaining 20wt% deionized waters dispersing and dissolving GUF licorice active components compound, Sucralose and color
Element is added to after stirring in vacuum Manufacturing medicine extract machine；
Step 4：Be added essence carry out high-speed stirred it is fully emulsified uniformly to get.
Comparative example 1 is Crest antibacterial toothpaste, and comparative example 2 is Japan GUM (Quan Shikang) toothpaste.
The toothpaste of embodiment 1-6 and comparative example 1-2 are measured into suppression minimum in toothpaste sample using trace liquid diluting method
Bacteria concentration MIC, experimental method are as follows：
1. testing bacterium
(different) streptococcus (Streptococcus mutans, CICC10387) is deformed, Chinese microorganism strain net is purchased from.
2, culture medium and incubator
Culture medium：CAMHB, anaerobism bag+anaerobism box (Mitsubishi Corporation of Japan).
3, test method
With reference to U.S. CLSI trace liquid diluting methods.
(1) preparation of bacteria suspension
Tested bacterium is inoculated in blood agar culture-medium and is activated through Anaerobic culturel 48h, the pure training after the identification of Grain stain microscopy
It supports.The pure culture bacterium colony for testing bacterium is diluted with sterile saline, it is 1 × 105CFU/mL to be finally diluted to bacterial concentration.
(2) preparation of test fluid
Each 4g of toothpaste test sample for weighing the toothpaste sample and embodiment 1-6 of comparative example 1-2 respectively, with 10ml distilled water
Dissolving, it is 0.4g/mL to prepare benchmark extract concentration.Then 14 gradients (table 1) are diluted to for 2 times.100 μ L to 96 are added dropwise respectively
On orifice plate.Separately set positive control：It is not added with test fluid, only adds bacterium solution and equivalent fluid nutrient medium；Negative control：It is not added with bacterium solution, only
Add test fluid and fluid nutrient medium.
1 diluted concentration of table (unit, g/mL)
| Extension rate | Benchmark concentration | 1 dilution | 2 dilutions | 3 dilutions | 4 dilutions | 5 dilutions | 6 dilutions |
| Concentration | 0.4 | 0.2 | 0.1 | 5.00E-02 | 2.50E-02 | 1.25E-02 | 6.25E-03 |
| Extension rate | 7 dilutions | 8 dilutions | 9 dilutions | 10 dilutions | 11 dilutions | 12 dilutions | 13 dilutions |
| Concentration | 3.13E-03 | 1.56E-03 | 7.81E-04 | 3.91E-04 | 1.95E-04 | 9.77E-05 | 4.88E-05 |
(3) minimal inhibitory concentration (MIC)
100 μ L of bacterium solution are taken to be added dropwise respectively on 96 orifice plates, Anaerobic culturel.When positive control is grown, each hole growth is observed
Situation determines minimal inhibitory concentration, and what is obtained the results are shown in Table 2.
Table 2GUF Radix Glycyrrhizae toothpaste bacteriostatic test results
| Experiment | Embodiment | GUF Radix Glycyrrhizaes % | Mlc MIC (g/ml) |
| 1 | Embodiment 1 | 0.5 | 0.4 |
| 2 | Embodiment 2 | 0.8 | 0.3 |
| 3 | Embodiment 3 | 1 | 0.15 |
| 4 | Embodiment 4 | 1.2 | 0.06 |
| 5 | Embodiment 5 | 1.5 | 0.035 |
| 6 | Embodiment 6 | 2 | 0.025 |
| 7 | Comparative example 1 | 0 | — |
| 8 | Comparative example 2 | 0 | 0.125 |
It can be seen that from the result that table 2 obtains：Toothpaste containing GUF licorice active components has apparent antibacterial work(
Effect, and evaluated in terms of using mouthfeel and drug effect two by trade debtor, GUF licorice active components account for the weight of the lotion of toothpaste
Amount is more suitable than for 0.01~10% comparison, and optimum optimization is 0.1~2%.When GUF licorice active components account for the weight of the lotion of toothpaste
When amount is than being 0.1~2%, drug effect and the mouthfeel of toothpaste are in optimum balance.
Claims (10)
1. a kind of GUF licorice active components composition, which is characterized in that the GUF licorice active components composition is by glycyrrhizic acid
Dipotassium, ammonium glycyrrhetate, disodium glycyrrhizinate and stearyl alcohol glycyrrhetin acid esters are (0.5-1) in mass ratio:(0.5-1):(0.1-1):
(0.1-1) is compounded.
2. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions, which is characterized in that the Radix Glycyrrhizae toothpaste is by weight
Number meter is measured, is made of following raw material：0.01-10 parts of GUF licorice active component compositions, 30-80 parts of moisturizer, rubbing agent
0-0.2 parts of 10-30 parts, 0.1-10 parts of foaming agent, 0.1-15 parts of thickener, 0-2 parts of aromatic, 0-1 parts of pH buffer and pigment.
3. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In the GUF licorice active components account for the 0.01-10% of the GUF Radix Glycyrrhizaes raw material of toothpaste total weight.
4. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In the GUF licorice active components account for the GUF Radix Glycyrrhizaes raw material of toothpaste total weight 0.1-2%.
5. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In the rubbing agent is silica.
6. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In counting in parts by weight, the moisturizer is made of following raw material：8-50 parts of sorbierite, 1-10 parts of glycerine, polyethylene glycol 400
1-5 parts and 10-20 parts of water.
7. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In counting in parts by weight, the thickener is made of 0.1-2 parts of 0.5-2 parts of cellulose gum and Chondrus crispus.
8. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In counting in parts by weight, the foaming agent is made of 0.1-2 parts of 1-8 parts of sldium lauryl sulfate and Cocoamidopropyl betaine.
9. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In counting in parts by weight, the aromatic is made of 0.01-0.3 parts of 0.5-1.5 parts of food flavor and tri-chloro galactose type sugar.
10. a kind of GUF Radix Glycyrrhizae toothpaste containing GUF licorice active component compositions according to claim 2, feature exist
In the pH buffer is tetrasodium pyrophosphate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938473A (en) * | 2018-09-19 | 2018-12-07 | 上海纯元萃生物科技有限公司 | A kind of herbaceous toothpaste and its preparation method and application for preventing and treating oral inflammation |
| CN110559253A (en) * | 2019-09-30 | 2019-12-13 | 曲沃李时珍医药科技有限公司 | toothpaste added with probiotics for resisting oral bacteria and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108938473A (en) * | 2018-09-19 | 2018-12-07 | 上海纯元萃生物科技有限公司 | A kind of herbaceous toothpaste and its preparation method and application for preventing and treating oral inflammation |
| CN110559253A (en) * | 2019-09-30 | 2019-12-13 | 曲沃李时珍医药科技有限公司 | toothpaste added with probiotics for resisting oral bacteria and preparation method thereof |
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Denomination of invention: A kind of GUF licorice active ingredient composition and GUF licorice toothpaste comprising the composition Effective date of registration: 20220920 Granted publication date: 20210423 Pledgee: Qinghai Beili licorice Technology Development Co.,Ltd. Pledgor: QINGHAI LAKE PHARMACEUTICAL CO.,LTD. Registration number: Y2022630000003 |