CN107184440A - A kind of dentifrice composition - Google Patents
A kind of dentifrice composition Download PDFInfo
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- CN107184440A CN107184440A CN201710597102.XA CN201710597102A CN107184440A CN 107184440 A CN107184440 A CN 107184440A CN 201710597102 A CN201710597102 A CN 201710597102A CN 107184440 A CN107184440 A CN 107184440A
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- peppermint
- dentifrice composition
- essential oil
- agent
- capsaicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
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- Birds (AREA)
- Chemical & Material Sciences (AREA)
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Abstract
The invention discloses a kind of dentifrice composition, it is surplus including 15 45wt% rubbing agents, 6 25wt% wetting agents, 0.4 1.6wt% adhesives, 2 5wt% foaming agents and diluent, the dentifrice composition includes the Peppermint essential oil that percentage by weight is 0.5 2.5wt% and 0.1 1.0wt% capsaicine.Dentifrice composition provided by the present invention, by using rubbing agent, wetting agent, foaming agent, adhesive, diluent, Peppermint essential oil and capsaicine is raw materials and are suitably matched, so that the dentifrice composition prepared not only has good taste, excellent stability and refrigerant sense, and greatly improve the persistence of its refrigerant peppery refreshing sense, during user uses the dentifrice composition, the refrigerant peppery refreshing sense experienced, so that the neuroceptor of user becomes active, even if user's moment is clear-headed, brings and become reconciled spirit using good implication.
Description
Technical field
The invention belongs to oral health technical field, and in particular to a kind of dentifrice composition.
Background technology
Toothpaste is the dental care product with toothbrush together teeth surfaces, is generally lived by rubbing agent, NMF, surface
Property agent, thickener, sweetener, preservative, active additive, and pigment, essence etc. mixes；With people's living standard
Raising, high-tech product is rooted in the hearts of the people, and develops to natural, multi items, multiscale, multifunctional direction, and feature toothpaste into
In order to sell focus.Wherein, the characteristics of Chinese herbal toothpaste is due to natural environmental-protective, good effect, Small side effects, increasingly by
The favor of consumer.
Also have using various active ingredient of Chinese herbs as toothpaste ancillary drug in the prior art, such as tianqi toothpaste, Yunnan
Baiyao toothpaste, shiny pricklyash toothpaste etc., effect is had nothing in common with each other.Using with make to clean, obtain in oral cavity the medicated toothpaste of refrigerant sense as
Example, in order to assign refrigerant sense, the fragrance component using menthol as representative generally coordinated in dentifrice composition is essential
's.But in recent years, the diet of greasy diet and a large amount of spicy materials of use is increasing, is desired to have the toothpaste of higher refrigerant sense
Composition.
As the method for improving refrigerant sense, there are the use level of increase fragrance component, or new addition ethanol equal solvent composition
Method, still, because if increasing the use level of these compositions, to it is intraoral stimulate strengthen, and exist due to suppress
The problem of bubbling, damage use feeling when brushing teeth.
Therefore, it is desired to not increase the use level of fragrance component and ethanol equal solvent and obtain the toothpaste of higher refrigerant sense.
Patent Document 1 discloses the dentifrice composition that a kind of refrigerant sense is excellent, it is characterised in that draws containing erythrite etc.
The composition of heat absorption hydration reaction is played, although it can obtain refrigerant sense, the refrigerant peppery refreshing sense in oral cavity is unable to reach, and
The intraoral cooling perception lasts time is not ideal enough, can not more realize the peppery refreshing sense of continuation length.
Patent document 1：Japanese Patent Laid-Open 2000-191483 publications.
The content of the invention
For prior art exist defect, the invention provides a kind of excellent combination property, refrigerant sense, it is peppery it is refreshing sense and
The dentifrice composition of refrigerant peppery refreshing sense duration length.
The purpose of the present invention is achieved through the following technical solutions：
A kind of dentifrice composition, including 15-45wt% rubbing agents, 6-25wt% wetting agents, 0.4-1.6wt% adhesives,
2-5wt% foaming agents and diluent are surplus, and it is the thin of 0.5-2.5wt% that the dentifrice composition, which includes percentage by weight,
The capsaicine of lotus essential oil and 0.1-1.0wt%.
Preferably, wherein the Peppermint essential oil be lemon-mint, watermelon ice cream peppermint, honey peach peppermint, tea perfume peppermint,
One kind in chrysanthemum peppermint, dual thin lotus, mango peppermint, jasmine peppermint, green tea peppermint and salubrious peppermint.
Preferably, wherein the content of the peppermint in the Peppermint essential oil is not less than menthol in 40wt%, and the peppermint
Content be 40-50wt%.
Preferably, wherein the rubbing agent is the one or more in calcium carbonate, calcium phosphate, silica；
The wetting agent is the one or more in sorbierite, glycerine, propane diols and polyethylene glycol 400；
Described adhesive is one kind in sodium carboxymethylcellulose, xanthans, hydroxyethyl cellulose, guar gum, carragheen
Or it is several；
The foaming agent is the one or more in lauroyl propylhomoserin sodium, lauryl sodium sulfate and glycine betaine；
The diluent is pure water.
Preferably, wherein the dentifrice composition include 0.8-1.5wt% Peppermint essential oil and 0.3-0.6wt% it is peppery
Green pepper element.
Preferably, wherein also including 0.1-0.5wt% saccharin sodium in described dentifrice composition.
The invention also discloses the preparation method of above-mentioned dentifrice composition, wherein by the percentage by weight by Peppermint essential oil,
Capsaicine, rubbing agent, wetting agent, adhesive, foaming agent and diluent mixing, are stirred with 500-800r/min rotating speeds, ground
Abrasive particle particle diameter obtains lotion of toothpaste to being less than 0.025-0.05mm and being deaerated under 0.06-0.1Mpa vacuum.
Preferably, by the percentage by weight：A, by wetting agent and saccharin sodium, be put into diluent with 500-800r/
Min rotating speeds, which stir, is made the pure aqueous solution, is mixed with rubbing agent, adhesive and foaming agent, with 500-800r/min rotating speeds
Stir, grain diameter of milling deaerates to less than 0.025-0.05mm and under 0.06-0.1Mpa vacuum；B, addition are thin
Lotus essential oil and capsaicine, stirred with 500-800r/min rotating speeds, mill grain diameter to be less than 0.025-0.05mm and
Deaerated under 0.06-0.1Mpa vacuum, obtain lotion of toothpaste.
In the present invention：
No. CAS of saccharin sodium be：128-44-9 (is free of the crystallization water), 6155-57-3 (containing two crystallizations water), chemical formula：
C6H4SO2NNaCO.2H2O, its chemical name is o-benzoic sulfimide sodium, also known as soluble saccharin, is the salt tolerant of saccharin,
Crystalline powder with two crystallizations water, colourless crystallization or with white, typically contains two crystallizations water, the volatile water that decrystallizes
And form anhydrous saccharin, white powder, odorless or it is micro- have fragrance, the dense sweet tea band of taste is bitter.Sugariness is 500 times of sucrose or so.It is resistance to
Heat and alkali resistance are weak, and sweet taste is heated under acid condition and is died down, solution is more than 0.026% bitter, be in food industry often
Synthetic sweetener, and usage history is most long, but be also most controversial synthetic sweetener.The sweetness ratio sucrose of saccharin sodium
300-500 times of sweet tea, is not decomposed in vivo, is excreted by kidney.But its toxicity is not strong, dispute is played main carcinogenic at its
Property, the sensation that toothpaste causes sweet tea in the sense of taste is mainly to confer in the present invention.
Carragheen (Carrageen, CAS 9000-07-1), also known as antler glue, carrageenan, Irish green moss glue, be
A kind of general designation of the polysaccharide extracted in (including Chondrus, Eucheuma, China fir Trentepohlia and husky Lepidium etc.) from marine red alga, is many
The mixture of material is planted, there is ι (Iota), κ (Kappa), λ (Lamda), four kinds of μ (mu).It is a kind of superior food additive of quality
Plus agent, with strong formation gel and high viscosity characteristic, gratifying elasticity, transparency and dissolubility, stability is very
It is good, also will not water even if heating in medium-sized and alkaline solution even if long-term place will not also reduce its gel strength and viscosity
Solution；, can be with forming interionic phase interaction between positively charged protein molecule with the good property combined with protein
With this unique reactivity is peerless in all colloids.In the present invention, it is mainly used in the adhesive of toothpaste.
PEG-400 is polyethylene glycol 400, and it is liquid, and it has the extensive compatibility with various solvents, is molten well
Agent and solubilizer, are widely used in liquid preparation, such as oral liquid, eye drops, the present invention, and it is mainly used in toothpaste solubilising
And wetting agent.
Glycerine is also known as glycerine, is no clear and bright thick liquid of color and taste sweet tea, odorless, has warm sweet taste, and tide can be absorbed from air
Gas, can also absorb hydrogen sulfide, hydrogen cyanide and sulfur dioxide, and relative density 1.26362,17.8 DEG C of fusing point, 290.0 DEG C of boiling point (divide
Solution), index of refraction 1.4746,176 DEG C of flash-point (opening cup), acute toxicity:LD50:31500mg/kg (rat oral), glycerine are
The framework ingredient of triglycerides molecule.In the present invention, its main function is the wetting agent and solubilizer as toothpaste, can make tooth
Composition in cream melts rapidly after meeting water, improves the quality of toothpaste.
Sorbierite is D-sorbite, English name Sorbitol, D-Glucitol, Sorbol, D-Sorbitol.Molecular formula is
C6H14O6, molecular weight is 182.17, is white hygroscopic powder or crystalline powder, sheet or particle, odorless.According to crystallization condition not
Together, fusing point changes in the range of 88~102 DEG C, relative density about 1.49, (1g is dissolved in about 0.45mL water) soluble in water, slightly soluble
In ethanol and acetic acid, there is refrigerant sweet taste, sugariness is about the half of sucrose, and calorific value is close with sucrose.In the present invention, it is mainly made
For wetting agent and antifreezing agent, lotion can be kept to lubricate, it is color and luster, in good taste.
Silica (chemical formula：SiO2) it is a kind of acidic oxide, correspondence hyrate is silicic acid (H2SiO3).Titanium dioxide
Silicon is one of most important compound of silicon, and its chemical property is more stable, water insoluble also not reacted with water.In the present invention, its
It is the main component of toothpaste as long as the rubbing agent as toothpaste, is that bacterial plaque, soft dirt and swill are easier to be brushed down
Come.Rubbing agent will have certain rubbing action, but can not damage facing i.e. periodontium.When teeth are brushed, silica suspends
Among foam, oral cavity is filled with, has with tartar and widely contacts, makes tartar easily by under scrub under the rubbing action of toothbrush
Come, as mouthwash spues.
Calcium phosphate (calcium phosphate, tribasic), chemical constitution this product is what multi-form calcium phosphate was constituted
Mixture.Insoluble in ethanol and acetone, water is slightly soluble in, watery hydrochloric acid and nitric acid is soluble in.It may be used as anticaking agent, acidity adjustment
Agent, nutritional supplement, fumet, stabilizer, water retention agent.In the present invention, it is mainly used in the rubbing agent of toothpaste.
Guar gum, is macromolecular Natural hydrophilic colloid, is mainly polymerized to food by galactolipin and mannose and forms, belong to day
One of right galactomannans, quality improver, a kind of natural thickener.Outward appearance is flowed freely from white to yellowish
Powder, can be dissolved in cold water or hot water, meet after water and formed colloid substance, reach the effect thickened rapidly.China《Food additives
Use sanitary standard》Be defined as shining in (GB2760-1996) is needed cautiously with being used in right amount in varieties of food items by production.This
In invention, it is mainly used in the adhesive of toothpaste so that toothpaste has good lubricity, mitigates mill of the rubbing agent to tooth
Damage；In addition, also having foam humidification, film forming ability and bonding force.
Native cellulose is that the most most polysaccharide of wide, content, very abundant of originating are distributed in nature.Current fibre element
Modification technology is concentrated mainly on etherificate and the aspect of esterification two.Cellulose obtains carboxymethyl cellulose (CMC) after carboxy methylation, its
The aqueous solution has the effects such as thickening, film forming, gluing, water tariff collection, colloid protection, emulsification and suspension, is widely used in oil, food
The industries such as product, medicine, textile and paper, are one of most important cellulose etherses.In the present invention, it is mainly used in glycerine shape
Into the aqueous solution as the matrix of toothpaste, be a excellent adhesive.
K-12 is lauryl sodium sulfate, belongs to anion surfactant, structural formula CH3(CH2)11OSO3Na, molecular weight
288.39, white is to micro-yellow powder, and micro- have a special gas, apparent density 0.25g/mL, 180~185 DEG C of fusing point (decomposition), easily
Water is dissolved in, HLB value is 40. nontoxic, and it is white or faint yellow powdery, is dissolved in water, insensitive to alkali and hard water.With decontamination,
Emulsification and excellent foaming power, its biological degradability>90%.Purposes：As emulsifying agent, extinguishing chemical, foaming agent and textile auxiliary；
Also serve as toothpaste and paste, powdery, shampoo are industrially usually used in detergent and textile industry.Be widely used in toothpaste, shampoo,
Hair cream, shampoo, washing powder, liquid are washed, cosmetics and plastics are stripped, the row such as lubrication and pharmacy, papermaking, building materials, chemical industry
Industry, in the present invention, it is mainly as foaming agent.
Glycine betaine is a kind of alkaline matter, is a kind of zwitterionic surfactant, on cosmetics have cleaning, foaming, it is wet
Profit, bactericidal action.And its effect is determined by the pH value in solution, often it is used together with teepol, it is possible to decrease
The excitant of teepol, and can increase the micella particle in solution, thus increase viscosity, it is usually used in hair washing
Essence, bath article, baby cleansing product etc., in the present invention, it is mainly as foaming agent.
Hamposyl L, to weak yellow liquid, there is special odor to be white.It is dissolved in the alcohol solutions such as water, ethanol or glycerine
In.At typical condition, it is all more stable to heat, acid, alkali.In the present invention, because it has superior foaminess and foam
It is fine and smooth, lasting, it is mainly used in the foaming agent of toothpaste.
Capsaicine ((trans) 8- methy-N-vanillyl -6- nonenamides) is the active component of capsicum, and it is to mammal
All irritant and can produce burning sensation in the oral cavity including the mankind, capsaicine and compound more associated therewith are simultaneously referred to as peppery
Green pepper member, they are the secondary metabolites that capsicum produces, and pure capsaicine is a kind of hydrophobic lipophilic, colourless odorless crystallization or wax-like
Compound.The capsaicine used in the present invention can be obtained by commercially available, the capsicum that such as company of MORINAGA MILK INDUSTRY Co., LTD. produces
Element, is made by following method and apparatus and dry capsicum meat 1) is handled using super critical extraction, is removed and is carried out self-desiccation
The extract of capsicum meat, and obtain residue；2) and then by jet mill crush the residue to form capsaicine.
Compared with prior art, the present invention at least has advantages below：
Dentifrice composition provided by the present invention, by using rubbing agent, wetting agent, foaming agent, adhesive, diluent,
Peppermint essential oil and capsaicine are raw material and suitably matched so that the dentifrice composition prepared not only has general tooth
Stability required by cream, and have the advantages that the duration of excellent refrigerant sense, peppery refreshing sense and refrigerant peppery refreshing sense is long.
During user uses the dentifrice composition, the refrigerant peppery strength experienced so that the neuroceptor of user becomes active,
Even if user's moment is clear-headed, brings and become reconciled spirit using good implication.
Embodiment
Below in conjunction with specific implementation, the present invention is described in detail.
When stated in the form of scope, preferred scope or preferred numerical upper limits and lower limit some amount, concentration or its
It is worth or when parameter, it should be understood that equivalent to it is specific disclose by by any pair of range limit or preferred value with appointing
Any scope that meaning range lower limit or preferred value combine, without considering whether the scope specifically discloses.Unless referred in addition
Go out, number range value listed herein is in the end points including scope, and all integers and fraction within the scope of this.
Unless otherwise indicated, all percentage, number, ratio herein etc. are by weight.
This paper material, method and embodiment is exemplary, and unless stated otherwise, be should not be construed as restricted
's.
Embodiment 1
The present embodiment provides a kind of dentifrice composition, and raw material components include：
Rubbing agent, 18wt%；
Wetting agent, 20wt%；
Foaming agent, 3wt%；
Adhesive, 1.6wt%；
Diluent, 55wt%；
Peppermint essential oil, 2.3wt%；
Capsaicine, 0.1wt%.
Wherein, the Peppermint essential oil selects lemon-mint；The content of peppermint in the Peppermint essential oil is 40wt%, and should
The content of menthol is 40wt% in peppermint；The particle size range of capsaicine is 1-380 μm, and the rubbing agent is calcium phosphate；It is described
Wetting agent is glycerine；Described adhesive is sodium carboxymethylcellulose and guar mixture, and sodium carboxymethylcellulose and Guar
The mass ratio of glue is 3:2；The foaming agent is lauroyl propylhomoserin sodium；The diluent is pure water.
Dentifrice composition described further is adopted to be prepared with the following method, is comprised the following steps that：
By above-mentioned percentage by weight by Peppermint essential oil, capsaicine, rubbing agent, wetting agent, adhesive, foaming agent and diluent
Mixing, is stirred, grain diameter of milling takes off to less than 0.03mm, and under 0.075Mpa vacuum with 600r/min rotating speeds
Gas, obtains lotion of toothpaste.
Comparative example 1
Component, proportioning and the preparation method of comparative example 2 etc. are same as Example 1, and difference is only to add thin
Lotus essential oil, and it is added without capsaicine component.
Comparative example 2
Component, proportioning and the preparation method of comparative example 2 etc. are same as Example 1, and difference is the thin of use
The content of peppermint in lotus essential oil is that the content of menthol in 35wt%, and the peppermint is 35wt%.
Comparative example 3
Component, proportioning and preparation method in comparative example 3 etc. are same as Example 1, and difference is what is used
The content of peppermint in Peppermint essential oil is that the content of menthol in 35wt%, and the peppermint is 45wt%.
Comparative example 4
Component, proportioning and preparation method in comparative example 4 etc. are same as Example 1, and difference is what is used
The content of peppermint in Peppermint essential oil is that the content of menthol in 40wt%, and the peppermint is 38wt%.
Comparative example 5
Component, proportioning and preparation method in comparative example 5 etc. are same as Example 1, and difference is what is used
The granularity of capsaicine is 3-300 μm.
Comparative example 6
Component, proportioning and preparation method in comparative example 6 etc. are same as Example 1, and difference is what is used
The granularity of capsaicine is 10-150 μm.
Embodiment 2
The present embodiment provides a kind of dentifrice composition, and raw material components include：
Rubbing agent, 35wt%；
Wetting agent, 15wt%；
Foaming agent, 2wt%；
Adhesive, 1wt%；
Diluent, 45.5wt%；
Peppermint essential oil, 1wt%；
Capsaicine, 0.5wt%.
Wherein, the Peppermint essential oil is mango peppermint；The content of peppermint in the Peppermint essential oil is not less than 40wt%, and
The content of menthol is 45wt% in the peppermint；The particle size range of capsaicine is 1-380 μm；The rubbing agent be calcium phosphate and
The mixture of silica, and the weight ratio of calcium phosphate and silica is 1:1；The wetting agent is sorbierite, glycerine, the third two
One or more in alcohol and polyethylene glycol 400, its weight percent content is 6-25wt%；Described adhesive is carboxymethyl
Sodium cellulosate；The foaming agent is lauryl sodium sulfate；The diluent is pure water.
Dentifrice composition described further is adopted to be prepared with the following method, is comprised the following steps that：
By above-mentioned percentage by weight by Peppermint essential oil, capsaicine, rubbing agent, wetting agent, adhesive, foaming agent and diluent
Mixing, is stirred, grain diameter of milling takes off to less than 0.03mm, and under 0.08Mpa vacuum with 680r/min rotating speeds
Gas, obtains lotion of toothpaste.
Embodiment 3
The present embodiment provides a kind of dentifrice composition, and raw material components include：
Rubbing agent, 42wt%；
Wetting agent, 10wt%；
Foaming agent, 4wt%；
Adhesive, 1.2wt%；
Diluent, 41.8wt%；
Peppermint essential oil, 0.7wt%；
Capsaicine, 0.3wt%.
Wherein, the Peppermint essential oil green tea peppermint；The content of peppermint in the Peppermint essential oil is 42wt%, and described thin
The content of menthol is 45wt% in lotus；The particle size range of capsaicine is 1-380 μm；The rubbing agent is silica；It is described
Wetting agent is the mixture of glycerine, propane diols and polyethylene glycol 400, and the mass ratio of glycerine, propane diols and polyethylene glycol 400
For 1:1:2；The mixture of the hydroxyethyl cellulose, guar gum and carragheen, and the hydroxyethyl cellulose, guar gum and
The mass ratio of carragheen is 2:1:1；The foaming agent is the mixture of lauroyl propylhomoserin sodium and glycine betaine, and lauroyl ammonia
The mass ratio of sour sodium and glycine betaine is 1:1；The diluent is pure water.
Dentifrice composition described further is adopted to be prepared with the following method, is comprised the following steps that：
By above-mentioned percentage by weight by Peppermint essential oil, capsaicine, rubbing agent, wetting agent, adhesive, foaming agent and diluent
Mixing, is stirred, grain diameter of milling takes off to less than 0.04mm, and under 0.075Mpa vacuum with 750r/min rotating speeds
Gas, obtains lotion of toothpaste.
Embodiment 4
The present embodiment provides a kind of dentifrice composition, and raw material components include：
Rubbing agent, 30wt%；
Wetting agent, 18wt%；
Foaming agent, 2.5wt%；
Adhesive, 0.8wt%；
Diluent, 45.4wt%；
Saccharin sodium, 0.3wt%；
Peppermint essential oil, 2.5wt%；
Capsaicine, 0.5wt%.
Wherein, the Peppermint essential oil selects lemon-mint；The content of peppermint in the Peppermint essential oil is 40wt%, and should
The content of menthol is 40wt% in peppermint；The particle size range of capsaicine is 1-380 μm；The rubbing agent is calcium phosphate；It is described
Wetting agent is glycerine；Described adhesive is sodium carboxymethylcellulose and guar mixture, and sodium carboxymethylcellulose and Guar
The mass ratio of glue is 3:2；The foaming agent is lauroyl propylhomoserin sodium；The diluent is pure water.
Dentifrice composition described further is adopted to be prepared with the following method, is comprised the following steps that：
By the percentage by weight：A, wetting agent and saccharin sodium, be put into diluent with 600r/min rotating speeds stir
The pure aqueous solution is uniformly made, is mixed with rubbing agent, adhesive and foaming agent, is stirred, milled with 720r/min rotating speeds
Grain particle diameter deaerates to below 0.035mm and under 0.08Mpa vacuum；B, addition Peppermint essential oil and capsaicine, with 700r/
Min rotating speeds stir, grain diameter of milling is less than 0.025mm and are deaerated under 0.09Mpa vacuum, obtain toothpaste cream
Body.
Experimental example
The dentifrice composition number consecutively that embodiment 1, comparative example 1-6 and embodiment 2-4 are prepared is A-J, right
The dentifrice composition carries out sensory evaluation, and evaluation method is 150 volunteer (wherein male 80, women 70) groups of invitation
Into scoring group, the refreshing sense of refrigerant sense, strength to toothpaste and refrigerant sense and the duration project of the refreshing sense of strength evaluate,
And, numbering is K with the Darlie of in the market as a control group, refrigerant sense and the refreshing sense of the strength main duration after after brushing
To consider.
This scoring uses hundred-mark system, because each project is different to the influence degree of product quality, therefore each project
The score value accounted for more is also different, and wherein refrigerant sense accounts for 25 points, peppery refreshing sense account for 25 points, refrigerant sense or refrigerant peppery refreshing sense duration account for 50
Point, during statistics dentifrice composition A-J obatained scores, first remove a best result and minimum point, last plot mean, each embodiment
Analyses Methods for Sensory Evaluation Results it is as shown in table 1.
The sensory evaluation scores table of the different dentifrice composition samples of table 1
As shown in Table 1, in embodiment A, H, I and J dentifrice composition, because adding Peppermint essential oil and capsaicine
Mixture, as a result the duration of its refrigerant sense, peppery refreshing sense and refrigerant peppery refreshing sense is preferable, and with Peppermint essential oil and capsicum
The increase of the mixture content of element, and the duration of its refrigerant peppery refreshing sense is longer, especially by taking embodiment 4 as an example, its is refrigerant peppery
As long as the duration of refreshing sense reaches 5.2min, changed certainly according to Peppermint essential oil and the ratio of capsaicine, perhaps the toothpaste group
The duration of the refrigerant peppery refreshing sense of compound is more preferably；On the other hand, it is only peppery refreshing due to not containing capsaicine in comparative example B
Essentially from peppermint in itself, the test value in this comparative example K is approached, almost imperceptible peppery refreshing sense for sense；Comparative example C, D and E
In, because the content of menthol in the content of peppermint in the Peppermint essential oil of use and peppermint is different, its refrigerant sense brought,
Peppery refreshing sense and refrigerant peppery refreshing sense are different, the menthol in the content of peppermint in Peppermint essential oil is less than 40wt% and peppermint
When content is less than 40wt%, the refrigerant sense effect embodied in Peppermint essential oil is poor；In comparative example F and G, when the grain using capsaicine
When footpath is 10-150 μm, then the persistence more excellent toothpaste of refrigerant sense, peppery refreshing sense and refrigerant peppery refreshing sense can be obtained
Composition, illustrates that the particle diameter of capsaicine has a significant impact to its refrigerant sense, peppery refreshing sense and refrigerant peppery refreshing sense persistence tool.
More than, it is only the present invention preferably embodiment, but the protection domain of invention is not limited thereto, and it is any ripe
Know those skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be defined by the protection domain of claims.
Claims (8)
1. a kind of dentifrice composition, it is characterised in that including 15-45wt% rubbing agents, 6-25wt% wetting agents, 0.4-
1.6wt% adhesives, 2-5wt% foaming agents and diluent are surplus, and the dentifrice composition includes percentage by weight and is
0.5-2.5wt% Peppermint essential oil and 0.1-1.0wt% capsaicine.
2. dentifrice composition according to claim 1, it is characterised in that the Peppermint essential oil is lemon-mint, watermelon ice
River in Henan Province drenches peppermint, honey peach peppermint, tea perfume peppermint, chrysanthemum peppermint, dual thin lotus, mango peppermint, jasmine peppermint, green tea peppermint and salubrious
One kind in peppermint.
3. dentifrice composition according to claim 1 or 2, it is characterised in that the content of the peppermint in the Peppermint essential oil
The content for being not less than menthol in 40wt%, and the peppermint is 40-50wt%.
4. dentifrice composition according to claim 1 or 2, it is characterised in that the rubbing agent be calcium carbonate, calcium phosphate,
One or more in silica；
The wetting agent is the one or more in sorbierite, glycerine, propane diols, polyethylene glycol 400；
Described adhesive is one kind or several in sodium carboxymethylcellulose, xanthans, hydroxyethyl cellulose, guar gum, carragheen
Kind；
The foaming agent is the one or more in lauroyl propylhomoserin sodium, lauryl sodium sulfate and glycine betaine；
The diluent is pure water.
5. dentifrice composition according to claim 1, it is characterised in that the dentifrice composition includes 0.8-
1.5wt% Peppermint essential oil and 0.3-0.6wt% capsaicine.
6. dentifrice composition according to claim 1, it is characterised in that also include 0.1- in the dentifrice composition
0.5wt% saccharin sodium.
7. according to the preparation method of dentifrice composition according to any one of claims 1 to 6, it is characterised in that by described heavy
Measure percentage to mix Peppermint essential oil and capsaicine, rubbing agent, wetting agent, adhesive, foaming agent and diluent, with 500-
800r/min rotating speeds stir, grain diameter of milling is to less than 0.025-0.05mm and under 0.06-0.1Mpa vacuum
Degassing, obtains lotion of toothpaste.
8. the preparation method of dentifrice composition according to claim 6, it is characterised in that by the percentage by weight：a、
By wetting agent and saccharin sodium, it is put into diluent to stir with 500-800r/min rotating speeds the pure aqueous solution is made, with rubs
Liniment, adhesive and foaming agent mixing, are stirred, grain diameter of milling extremely is less than 0.025- with 500-800r/min rotating speeds
0.05mm simultaneously deaerates under 0.06-0.1Mpa vacuum；B, addition Peppermint essential oil and capsaicine, with 500-800r/min rotating speeds
Stir, grain diameter of milling deaerates to less than 0.025-0.05mm and under 0.06-0.1Mpa vacuum, obtains toothpaste
Lotion.
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| CN201710597102.XA CN107184440A (en) | 2017-07-20 | 2017-07-20 | A kind of dentifrice composition |
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| CN107693438A (en) * | 2017-11-27 | 2018-02-16 | 大连丹特生物技术有限公司 | A kind of daystart toothpaste and preparation method thereof |
| CN108379106A (en) * | 2018-04-27 | 2018-08-10 | 青海省青海湖药业有限公司 | A kind of GUF licorice active components composition and the GUF Radix Glycyrrhizae toothpaste comprising the composition |
| WO2019241990A1 (en) * | 2018-06-22 | 2019-12-26 | The Procter & Gamble Company | Dentifrice compositions |
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Application publication date: 20170922 |