CN106511112A

CN106511112A - Toothpaste with lasting cooling and bacteriostatic effects and preparation method of toothpaste

Info

Publication number: CN106511112A
Application number: CN201611147447.7A
Authority: CN
Inventors: 徐天生; 李毅苹; 高玉云; 黄秀娟
Original assignee: MEICHEN GROUP CO Ltd
Current assignee: Dr. Kang Daihua Group Co.,Ltd.
Priority date: 2016-12-13
Filing date: 2016-12-13
Publication date: 2017-03-22
Anticipated expiration: 2036-12-13
Also published as: CN106511112B

Abstract

The invention discloses composition with cooling and bacteriostatic effects. The composition comprises components as follows: a freshener, a bacteriostatic agent and high-molecular polymers capable of being complexed with the bacteriostatic agent. The invention further discloses toothpaste with lasting cooling and bacteriostatic effects. Preparation raw materials of the toothpaste comprise a humectant, an abrasive agent, a binding agent, a foaming agent, edible essence, water and the composition. Due to good binding property and film forming property of the high-molecular polymers, when the toothpaste with the lasting cooling and bacteriostatic effects is used, the freshener and the bacteriostatic agent can still adhere to the oral mucosa along with the high-molecular polymers after the toothpaste is used, a thin film is formed, and the lasting cooling and bacteriostatic effects are realized.

Description

A kind of persistently refrigerant antibacterial toothpaste and preparation method thereof

Technical field

The invention belongs to field of oral care, more particularly to a kind of persistently refrigerant antibacterial toothpaste and preparation method thereof.

Background technology

Halitosis referred to from oral cavity or other cavitys full of air such as nose, nasal sinus, pharynx, the foul smell peculiar smell for being given out, It affects the normal contacts of people and exchanges, and affects the social image and mental health of itself.One recent investigation shows Show, the incidence of disease of the halitosis in Chinese population has reached 27.5%, its pathogenic factor belong to the patient of oral cavity intrinsic factor account for 80～ 90%.Mouth source property halitosis mainly decomposes the materials such as sulfur-containing amino acid, peptide and protein by oral cavity bacterium is corrupt, generation Caused by volatile sulfur compounds and the aliphatic acid with peculiar smell.Therefore, for mouth source property halitosis can produce halitosis by removing Pathogenic microorganism and its generation toxin and it is rapid directly remove in oral cavity smelly class chemical compound gas to suppress halitosis, it is pure and fresh Implication.

At present, numerous studies have been done in terms of fresh breath, suppression halitosis.For example, Application No. " CN931060702 " Patent of invention disclose the refrigerant effect of collaboration of the compositions such as menthol, amide of mint, menthone glycerol ketals and its simple Using.For the patent of invention of " CN1124126C ", Authorization Notice No. elaborates that menthol and its combination application of derivative can be obtained The cooling effect of collaboration.Application publication number refer to a kind of coolant compositions by gathering for the patent of invention of " CN0577837 A " Glutamic acid and oil-soluble freshener composition, in the presence of polyglutamic acid, the release time of freshener is extended.Shen Qing Publication Number for " CN104257544 A " patent of invention refer to using cyclodextrin, Gantrez AN-119, Tea Polyphenols etc. remove halitosis. Authorization Notice No. for " CN102512337 B " patent of invention refer to polyvinylpyrrolidone, polypropylene copolymer etc. with it is double Chlorhexidine, dodecyl benzyl dimethyl ammonium chloride, cetylpyridinium chloride are used, and extend the antibacterial time.

In techniques disclosed above, when the utilization of freshener is related to, have studied freshener and be applied in combination and can play collaboration Effect, strengthens refrigerant degree, but has been short of in refrigerant persistence, also has the research for extending persistence using polyglutamic acid, But based on cosmetics of everyday use, the price of polyglutamic acid is higher, needs unsuitable for basic commodity industrialization；It is related to bacteriostatic agent Utilization when, have the research being used in conjunction to high molecular polymer and bacteriostatic agent, but above only to chlorhexidine, dodecyl dimethyl benzyl The superpower effect bacteriostatic agent such as ammonium chloride and plant extracts Tea Polyphenols are studied, and propose the research of bacteriostatic agent to the present invention It has been short of.

The content of the invention

On the one hand, it is an object of the invention to overcome the weak point of prior art presence and provide a kind of persistently refrigerant Antibacterial composition, the composition of the present invention more can rationally control industrialization cost by selecting suitable component, and such as combining makes With the more cheap high molecular polymer of mature industry, freshener and bacteriostatic agent, extend the refrigerant degree of product and fungistatic effect.

The technical solution used in the present invention is：A kind of persistently refrigerant antibacterial composition, which includes following components：It is refrigerant Agent, bacteriostatic agent and the high molecular polymer that can be complexed with the bacteriostatic agent.

As the further improvement to above-mentioned technical proposal, count by weight, the consumption of each component is：Freshener 0.2 0.1～20 part of～4 parts, 0.01～4 part of bacteriostatic agent and high molecular polymer.

The freshener may be selected from peppermint derivative, used as the further improvement to above-mentioned technical proposal, the freshener Including menthol (2- isopropyl -5- methyl cyclohexanols), menthyl lactate (2 hydroxy propanoic acid -5- methyl -2- isopropyl hexamethylenes Ester), amide of mint (N- ethyls-to menthyl -3- formamides), menthyl acetate (acetic acid -5- methyl -2- isopropyl hexamethylenes Ester), menthone glycerol ketals (6- isopropyl -9- methyl isophthalic acids, 4- dioxy spiral shells (4,5)-decane -2- methyl alcohol), WS-23 (N, 2,3- Trimethyl -2- butanamides), in WS-5 (N- (ethoxycarbonylmethyl group)-to alkane -3- formamides) and their derivative It is at least one；

Used as the further improvement to above-mentioned technical proposal, the bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic Ag⁺, at least one in cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class (such as Quaternium 24). It is highly preferred that the bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic Ag⁺, cetylpyridinium chloride and double alkyl two In ammonio methacrylate class at least two.

Used as the further improvement to above-mentioned technical proposal, the high molecular polymer includes acrylic copolymer (such as Polyacrylate) and vinyl-based copolymer (such as polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer).More Preferably, the high molecular polymer is the mixture of polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer, Wherein, the weight ratio of polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer is 1～100：1～100.

On the other hand, present invention also offers application of the compositions as described above in oral-cavity cleaning products.

Another aspect, present invention also offers a kind of persistently refrigerant antibacterial toothpaste, the preparing raw material of the toothpaste is included： NMF, rubbing agent, adhesive, foaming agent, flavoring essence, water and compositions as described above.

Used as the further improvement to above-mentioned technical proposal, by weight percentage densimeter, the toothpaste includes following system Standby raw material：NMF 23～72%, rubbing agent 12～60%, adhesive 1～4%, foaming agent 1.5～6%, flavoring essence 0.8 ～2%, composition 0.31～28%, balance of water.

Used as the further improvement to above-mentioned technical proposal, the preparing raw material also includes sweetener.Preferably, it is described sweet Taste agent includes at least one in saccharin sodium, stevioside, Sucralose.

As the further improvement to above-mentioned technical proposal, the NMF include sorbierite, polyethylene glycol, propane diols, At least one in glycerine.

Used as the further improvement to above-mentioned technical proposal, the rubbing agent includes silica, calcium carbonate, calcium monohydrogen phosphate In at least one.

Used as the further improvement to above-mentioned technical proposal, described adhesive includes sodium carboxymethylcellulose (CMC), xanthan At least one in glue, carragheen.

Used as the further improvement to above-mentioned technical proposal, the foaming agent includes lauryl sodium sulfate, moon silicic acid flesh At least one in propylhomoserin sodium, Cocoamidopropyl betaine, APG.

Another further aspect, present invention also offers the preparation method of above-described persistently refrigerant antibacterial toothpaste, including with Lower step：After by the NMF, rubbing agent, adhesive, water, foaming agent, sweetener, high molecular polymer mixing, keep true Reciprocal of duty cycle is stirred 20～50 minutes in -0.090 Mpa～-0.096Mpa；Thereafter add the flavoring essence, freshener, antibacterial Agent, keeps vacuum in -0.090 Mpa～-0.096Mpa, stirs 10～50 minutes, lotion is obtained.

Relative to prior art, beneficial effects of the present invention are：

1) present invention is on the basis of freshener is applied in combination, connected applications industry-wide and more cheap macromolecule Polymer, on the basis of the cool degree of freshener is strengthened can extend the time of cooling effect, adapts to Market Consumer demand；

2) present invention is studied with reference to high molecular polymer application to target bacteriostatic agent, good in high molecular polymer Cohesive and film forming promotion under, extend the bacteriostasis time of bacteriostatic agent, with reference to by compound bacteriostatic agent, serve Preferably fungistatic effect, has preferably lifting in the economic profit of enterprise and the safety in utilization of consumer.

3), after freshener and bacteriostatic agent are fully mixed in high molecular polymer and make toothpaste, bacteriostatic agent can be multiple with macromolecule Compound is complexed, and when using toothpaste, as high molecular polymer has good cohesive and film forming, is using toothpaste Afterwards, remain to make freshener and bacteriostatic agent as high molecular polymer is sticked at oral mucosa, and form film, reach persistently clear Cool and antibacterial effect.

Specific embodiment

The embodiment provides a kind of composition, which includes following components：Freshener, bacteriostatic agent and can be with The high molecular polymer is complexed by the bacteriostatic agent.

Wherein, count by weight, the consumption of each component is：0.2～4 part of freshener, 0.01～4 part of bacteriostatic agent and high score 0.1～20 part of sub- polymer.

The freshener may be selected from peppermint derivative, it is preferable that the freshener includes menthol (2- isopropyl -5- first Cyclohexanol), menthyl lactate (2 hydroxy propanoic acid -5- methyl -2- isopropyl cyclohexyls), amide of mint (N- ethyls-to peppermint Base -3- formamides), menthyl acetate (acetic acid -5- methyl -2- isopropyl cyclohexyls), menthone glycerol ketals (6- isopropyls - 9- methyl isophthalic acids, 4- dioxy spiral shells (4,5)-decane -2- methyl alcohol), WS-23 (N, 2,3- trimethyl -2- butanamides), WS-5 At least one in (N- (ethoxycarbonylmethyl group)-to alkane -3- formamides) and their derivative.In order to improve cooling effect, Increase refrigerant degree, it is preferable that the freshener is selected from following combination：(1) mixture of menthol and amide of mint, wherein, it is thin The weight ratio of lotus alcohol and amide of mint is 1～20：1～20；(2) mixture of menthol and menthone glycerol ketals, wherein, it is thin The weight ratio of lotus alcohol and menthone glycerol ketals is 1～20：1～20.

The bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic Ag⁺, Dialkyl dimethyl ammonium chloride class is (as two pungent Base alkyl dimethyl ammonium chloride) and cetylpyridinium chloride at least one.Preferably, the bacteriostatic agent is o- cymene -5- Alcohol, nano-silver ionic Ag⁺In at least one.Wherein, o- cymenes -5- alcohol is not belonging to cationic germicide, and its feature exists In its sterilization mode, with efficient penetrating power, can penetrate into bacterial plaque, kill oral cavity pathogen；Nanometer Ag⁺Can be strong Sulfydryl (- SH) in ground attraction bacterial body on protease, rapidly together with it, makes protease loss of activity, causes thin Bacterium is dead.After bacterium is killed by Ag+, Ag+ is again by separate out in bacterium corpse, then contacts with other bacterium colonies, again and again Proceed as described above, be silver-colored sterilized persistent sterilized mechanism, so Ag+ is more efficient.

Preferably, the bacteriostatic agent is o- cymene -5- alcohol, nano-silver ionic Ag⁺, cetylpyridinium chloride and double alkane At least two mixing of base alkyl dimethyl ammonium chloride class.It has been investigated that, after the reasonable compounding use of two or more bacteriostatic agents, in high score In the presence of sub- polymer, more preferably more longlasting fungistatic effect is had.

The high molecular polymer includes acrylic copolymer (such as polyacrylate) and vinyl-based copolymer (as gathered Vinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer).Preferably, the high molecular polymer is polyethylene pyrrole The mixture of pyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer, wherein, polyvinylpyrrolidone and methyl ethylene The weight ratio of ether-maleic acid glycosides copolymer is 1～100：1～100.Test proves polyvinylpyrrolidone and methyl ethylene Ether-maleic acid glycosides polymer combination using effect is substantially better than the effect of both exclusive uses.

Embodiments of the invention additionally provide application of the compositions as described above in oral-cavity cleaning products, such as in tooth Application in cream.

Embodiments of the invention additionally provide a kind of persistently refrigerant antibacterial toothpaste, and the preparing raw material of the toothpaste is included： NMF, rubbing agent, adhesive, foaming agent, flavoring essence, water and compositions as described above.

Wherein, densimeter by weight percentage, the toothpaste include following preparing raw material：NMF 23～72%, friction Agent 12～60%, adhesive 1～4%, foaming agent 1.5～6%, flavoring essence 0.8～2%, composition 0.31～28%, surplus For water.

In a specific embodiment, the preparing raw material also includes sweetener.Preferably, the sweetener includes saccharin At least one in sodium, stevioside, Sucralose.

The NMF includes at least one in sorbierite, polyethylene glycol, propane diols, glycerine；In order to further improve The stability of lotion of toothpaste, it is preferable that mixture of the NMF for sorbierite, polyethylene glycol and propane diols, and sorbierite, The weight ratio of polyethylene glycol and propane diols is 20-50：1-10：2-12.

The rubbing agent includes at least one in silica, calcium carbonate, calcium monohydrogen phosphate.

Described adhesive includes at least one in sodium carboxymethylcellulose (CMC), xanthans, carragheen.

The foaming agent includes lauryl sodium sulfate, moon silicic acid sodium sarcosinate, Cocoamidopropyl betaine, alkyl sugar At least one in glycosides.

In one preferred embodiment, a kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, described The preparing raw material of toothpaste is included：

Sorbierite 20%-35%

PEG-8 1%-10%

Glycerine 2%-12%

Sodium carboxymethylcellulose 0.8%-2%

Carragheen 0.8%-2%

Lauryl sodium sulfate 1%-3%

Sodium lauroyl sarcosine 0.5%-2.5%

Calcium carbonate 38%-52%

Silica 2%-8%

Polyacrylate 0.1%-10%

Saccharin sodium 0.1%-0.3%

O- cymene -5- alcohol 0.01%-0.1%

Menthol 0.1%-2%

Amide of mint 0.1%-2%

Essence 0.8%-2%

Deionized water surplus.

Another preferred embodiment in, a kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, institute The preparing raw material for stating toothpaste is included：

Sorbierite 20%-50%

PEG-8 1%-10%

Propane diols 2%-12%

Sodium carboxymethylcellulose 0.8%-2%

Xanthans 0.2%-2%

Lauryl sodium sulfate 1%-3%

Cocoamidopropyl betaine 0.5%-3%

Silica 1 2%-30%

Polyvinylpyrrolidone 0.1%-10%

Methyl vinyl ether-maleic acid glycosides copolymer 0.1%-10%

Saccharin sodium 0.1%-0.3%

Sucralose 0.1%-0.3%

Titanium dioxide 0.1%-1%

Ag⁺0.1%-2%

Menthol 0.1%-2%

Menthone glycerol ketals 0.1%-2%

Essence 0.8%-2%

Deionized water surplus.

Sorbierite 20%-50%

PEG-8 1%-10%

Propane diols 2%-12%

Sodium carboxymethylcellulose 0.8%-2%

Xanthans 0.2%-2%

Lauryl sodium sulfate 1%-3%

Cocoamidopropyl betaine 0.5%-3%

Silica 1 2%-30%

Polyvinylpyrrolidone 0.1%-10%

Methyl vinyl ether-maleic acid glycosides copolymer 0.1%-10%

Saccharin sodium 0.1%-0.3%

Sucralose 0.1%-0.3%

Titanium dioxide 0.1%-1%

Cetylpyridinium chloride 0.1%-2%

Ag⁺0.1%-2%

Menthol 0.1%-2%

Menthone glycerol ketals 0.1%-2%

Essence 0.8%-2%

Deionized water surplus.

Embodiments of the invention additionally provide the preparation method of above-described persistently refrigerant antibacterial toothpaste, including following Step：After by the above NMF, rubbing agent, water, foaming agent, adhesive, high molecular polymer, sweetener mixing, keep Vacuum is stirred 20～50 minutes in -0.090 Mpa～-0.096Mpa；Thereafter add the flavoring essence, freshener, antibacterial Agent, keeps vacuum in -0.090 Mpa～-0.096Mpa, stirs 10～50 minutes, lotion of toothpaste is obtained.

Above-described freshener and bacteriostatic agent are fully mixed after making toothpaste in high molecular polymer, and bacteriostatic agent can be with Polymer composite is complexed, when using toothpaste, as high molecular polymer has good cohesive and film forming, After using toothpaste, remain to make freshener and bacteriostatic agent as high molecular polymer is sticked at oral mucosa, and form film, reach To persistently refrigerant and antibacterial effect.

To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention It is described further.

Embodiment 1

A kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, the preparing raw material of the toothpaste are included：

Sorbierite 20%

PEG-8 5%

Glycerine 6%

Sodium carboxymethylcellulose 0.8%

Carragheen 2%

Lauryl sodium sulfate 1%

Sodium lauroyl sarcosine 2.5%

Calcium carbonate 52%

Silica 2%

Polyacrylate 0.1%

Saccharin sodium 0.1%

O- cymene -5- alcohol 0.01%

Menthol 0.1%

Amide of mint 2%

Essence 0.8%

Deionized water surplus；

Wherein, sorbierite, PEG-8, glycerine be NMF, sodium carboxymethylcellulose, carragheen be binding agent, ten Sodium dialkyl sulfate, sodium lauroyl sarcosine are foaming agent, and calcium carbonate, silica are rubbing agent, and polyacrylate is high score Sub- polymer, saccharin sodium are sweetener, and o- cymene -5- alcohol is bacteriostatic agent, and menthol, amide of mint are freshener.

The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment, comprises the following steps：By NMF, rubbing agent, After water, foaming agent, adhesive, high molecular polymer, sweetener mix, keep vacuum in -0.090Mpa, stir 50 minutes； Thereafter the flavoring essence, freshener, bacteriostatic agent are added, is kept vacuum in -0.090 MpaMpa, is stirred 50 minutes, be obtained Lotion of toothpaste.

Embodiment 2

Sorbierite 35%

PEG-8 1%

Glycerine 2%

Sodium carboxymethylcellulose 2%

Carragheen 0.8%

Lauryl sodium sulfate 3%

Sodium lauroyl sarcosine 0.5%

Calcium carbonate 38%

Silica 5%

Polyacrylate 5%

Saccharin sodium 0.3%

O- cymene -5- alcohol 0.05%

Menthol 2%

Amide of mint 0.1%

Essence 2%

Deionized water surplus；

The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment, comprises the following steps：By the above NMF, After rubbing agent, water, foaming agent, adhesive, high molecular polymer, sweetener mix, vacuum is kept in -0.096Mpa, stirring 20 minutes；Thereafter the flavoring essence, freshener, bacteriostatic agent are added, is kept vacuum in -0.096Mpa, is stirred 10 minutes, system Obtain lotion of toothpaste.

Embodiment 3

Sorbierite 22%

PEG-8 7%

Glycerine 2%

Sodium carboxymethylcellulose 1%

Carragheen 1%

Lauryl sodium sulfate 2%

Sodium lauroyl sarcosine 1%

Calcium carbonate 40%

Silica 8%

Polyacrylate 10%

Saccharin sodium 0.2%

O- cymene -5- alcohol 0.1%

Menthol 0.3%

Amide of mint 0.3%

Essence 1%

Deionized water surplus；

The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment, comprises the following steps：By the above NMF, After rubbing agent, water, foaming agent, adhesive, high molecular polymer, sweetener mix, vacuum is kept in -0.093 Mpa, stirring 30 minutes；Thereafter the flavoring essence, freshener, bacteriostatic agent are added, are kept vacuum in -0.093 Mpa, is stirred 30 minutes, Prepared lotion of toothpaste.

Embodiment 4

Sorbierite 50%

PEG-8 1%

Propane diols 2%

Sodium carboxymethylcellulose 0.8%

Xanthans 2%

Lauryl sodium sulfate 1%

Cocoamidopropyl betaine 3%

Silica 1 2%

Polyvinylpyrrolidone 5%

Methyl vinyl ether-maleic acid glycosides copolymer 1 0%

Saccharin sodium 0.3%

Sucralose 0.1%

Titanium dioxide 0.1%

Ag⁺2%

Menthol 0.1%

Menthone glycerol ketals 2%

Essence 0.8%

Deionized water surplus；

Wherein, sorbierite, PEG-8, propane diols are NMF, and sodium carboxymethylcellulose, xanthans are binding agent, Lauryl sodium sulfate, Cocoamidopropyl betaine are foaming agent, and silica is rubbing agent, polyvinylpyrrolidone, first Base vinylether-maleic acid glycosides copolymer be high molecular polymer, saccharin sodium, Sucralose be sweetener, Ag⁺For bacteriostatic agent, Menthol, menthone glycerol ketals are freshener.

The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is with embodiment 3.

Embodiment 5

Sorbierite 20%

PEG-8 10%

Propane diols 12%

Sodium carboxymethylcellulose 2%

Xanthans 0.2%

Lauryl sodium sulfate 3%

Cocoamidopropyl betaine 0.5%

Silica 30%

Polyvinylpyrrolidone 0.5%

Methyl vinyl ether-maleic acid glycosides copolymer 5%

Saccharin sodium 0.1%

Sucralose 0.3%

Titanium dioxide 1%

Ag⁺1%

Menthol 1%

Menthone glycerol ketals 1%

Essence 1%

Deionized water surplus；

Embodiment 6

Sorbierite 30%

PEG-8 6%

Propane diols 10%

Sodium carboxymethylcellulose 1.5%

Xanthans 1.2%

Lauryl sodium sulfate 2%

Cocoamidopropyl betaine 2%

Silica 25%

Polyvinylpyrrolidone 0.1%

Methyl vinyl ether-maleic acid glycosides copolymer 1 0%

Saccharin sodium 0.2%

Sucralose 0.2%

Titanium dioxide 0.5%

Ag⁺0.1%

Menthol 2%

Menthone glycerol ketals 0.1%

Essence 2%

Deionized water surplus；

Embodiment 7

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment is cetylpyridinium chloride except bacteriostatic agent, and Outside its consumption is 2%, remaining is with embodiment 4.

The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is with embodiment 4.

Embodiment 8

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment is cetylpyridinium chloride except bacteriostatic agent, and Outside its consumption is 1%, remaining is with embodiment 5.

The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is with embodiment 5.

Embodiment 9

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment is cetylpyridinium chloride except bacteriostatic agent, and Outside its consumption is 0.1%, remaining is with embodiment 6.

The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is with embodiment 6.

Embodiment 10

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment is Ag except bacteriostatic agent⁺With hexadecyl pyrrole The mixture of pyridine, and outside both consumption sums are 2%, remaining is with embodiment 4.

Embodiment 11

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment is Ag except bacteriostatic agent⁺With hexadecyl pyrrole The mixture of pyridine, and outside both consumption sums are 1%, remaining is with embodiment 5.

Embodiment 12

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment is Ag except bacteriostatic agent⁺With hexadecyl pyrrole The mixture of pyridine, and outside both consumption sums are 0.1%, remaining is with embodiment 6.

Embodiment 13

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment is polyvinylpyrrolidine except high molecular polymer Ketone, and outside its consumption is 5.5%, remaining is with embodiment 5.

Embodiment 14

The preparing raw material of the lasting refrigerant antibacterial toothpaste of the present embodiment except high molecular polymer be methyl vinyl ether- Maleic acid glycosides copolymer, and outside its consumption is 5.5%, remaining is with embodiment 5.

Embodiment 15

Lasting refrigerant antibacterial toothpaste obtained in embodiment 1～14 is placed on into 50 DEG C of baking oven 3 months, sample stability Normally, physical and chemical index is without exception, and sample fragrance is basically identical with normal temperature sample.In 3 months, high temp samples and normal temperature sample each side Face is all basically identical, and general stability is good, complies with the national standard requirements.

Toothpaste effect test

By toothpaste obtained in embodiment 1～3 and blank sample, (in addition to without polyacrylate, remaining proportioning is the same, few Amount is filled in the water yield) refrigerant degree duration running is carried out, test method is to select the crowd 60 more sensitive to cool degree, according to Following standard degree persistence refrigerant to toothpaste scores.

Refrigerant degree persistence evaluation criterion

Effect data

From the results, it was seen that with the help of high molecular polymer polyacrylate, toothpaste obtained in embodiment 1～3 Refrigerant persistence has and is obviously improved.

By toothpaste obtained in embodiment 4～6 and blank sample (except without polyvinylpyrrolidone, methyl vinyl ether-horse Carry out sour glycosides copolymerization beyond the region of objective existence, remaining proportioning is the same, few amount is filled in the water yield), toothpaste obtained in embodiment 7～9 carry out antibacterial holding Degree test long, test method is to select 150 oral cavity gingivitis patients, is randomly divided into 3 groups, and one group uses embodiment 4～6 Obtained toothpaste, one group uses blank sample toothpaste, and last group uses toothpaste obtained in embodiment 7～9, using complete toothpaste Afterwards, to oral cavity flora (with porphyromonas gingivalis, Fusobacterium nucleatum, Candida albicans, Prevotella intermedia, lactobacillus acidophilus it is Monitoring objective) it was monitored every 2 hours, to monitor 12 hours altogether, data are as follows：

From the results, it was seen that in high molecular polymer polyvinylpyrrolidone, methyl vinyl ether-maleic acid glycosides copolymerization In the presence of thing, the toothpaste sample of the less pbz polymer polymer of toothpaste obtained in embodiment 4～9 is in bacteriostasis property persistence There is obvious lifting, and also can find out from toothpaste obtained in embodiment 10～12, in high molecular polymer polyethylene In the presence of pyrrolidones, methyl vinyl ether-maleic acid glycosides copolymer, compounding use bacteriostatic agent Ag⁺And hexadecyl Pyridine contrast is used alone Ag⁺When, bacteriostasis property is more preferably more longlasting.

As space is limited, do not list the bacteriostasis rate of each embodiment in upper table one by one, the bacteriostasis rate in upper table is respectively implemented The average bacteriostasis rate of toothpaste obtained in example 4～9, the average bacteriostasis rate of blank control group and toothpaste obtained in embodiment 10～12 Average bacteriostasis rate.According to result of the test, the fungistatic effect of embodiment 10 is significantly better than embodiment 4 and 7, embodiment 11 it is antibacterial Effect is significant is better than embodiment 5 and 8, and the fungistatic effect of embodiment 12 is significantly better than embodiment 6 and 9, with the average bacteriostasis rate of use The result of expression is consistent.

Additionally, test proves that persistently the using effect of refrigerant antibacterial toothpaste is better than 13 He of embodiment obtained in embodiment 5 The effect of lasting refrigerant antibacterial toothpaste obtained in embodiment 14, the lasting refrigerant degree of refrigerant antibacterial toothpaste obtained in embodiment 5 Duration is longer, and bacteriostasis rate is higher under comparable conditions.

Last should be noted that above example is only to illustrate technical scheme rather than the present invention is protected The restriction of shield scope, although being explained in detail to the present invention with reference to preferred embodiment, one of ordinary skill in the art should Understand, technical scheme can be modified or equivalent, without deviating from the essence of technical solution of the present invention And scope.

Claims

1. a kind of persistently refrigerant antibacterial composition, it is characterised in that：Comprising following components：Freshener, bacteriostatic agent and can The high molecular polymer being complexed with the bacteriostatic agent.

2. composition according to claim 1, it is characterised in that：Count by weight, the consumption of each component is：Freshener 0.1～20 part of 0.2～4 part, 0.01～4 part of bacteriostatic agent and high molecular polymer.

3. composition according to claim 1, it is characterised in that：The freshener includes menthol, menthyl lactate, thin At least one in lotus acid amides, menthyl acetate, menthone glycerol ketals, WS-23, WS-5 and their derivative；

The bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic Ag⁺, cetylpyridinium chloride and double alkyl dimethyl chlorine Change at least one in ammonium class；

The high molecular polymer includes acrylic copolymer and vinyl-based copolymer.

4. composition according to claim 1, it is characterised in that：The bacteriostatic agent includes o- cymene -5- alcohol, Nano Silver Ion A g⁺, in cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class at least two.

5. the lasting refrigerant antibacterial composition according to any one of Claims 1 to 4 in oral-cavity cleaning products should With.

6. a kind of persistently refrigerant antibacterial toothpaste, it is characterised in that：The preparing raw material of the toothpaste is included：NMF, rubbing agent, Composition any one of adhesive, foaming agent, flavoring essence, water and Claims 1 to 4.

7. persistently refrigerant antibacterial toothpaste according to claim 6, it is characterised in that：Densimeter by weight percentage, institute Toothpaste is stated comprising following preparing raw material：NMF 23～72%, rubbing agent 12～60%, adhesive 1～4%, foaming agent 1.5～ 6%th, flavoring essence 0.8～2%, composition 0.31～28%, balance of water.

8. persistently refrigerant antibacterial toothpaste according to claim 7, it is characterised in that：The preparing raw material also includes sweet taste Agent.

9. persistently refrigerant antibacterial toothpaste according to claim 6, it is characterised in that：The NMF include sorbierite, At least one in polyethylene glycol, propane diols, glycerine；

The rubbing agent includes at least one in silica, calcium carbonate, calcium monohydrogen phosphate；

Described adhesive includes at least one in sodium carboxymethylcellulose, xanthans, carragheen；

During the foaming agent includes lauryl sodium sulfate, moon silicic acid sodium sarcosinate, Cocoamidopropyl betaine, APG At least one.

10. the preparation method of the lasting refrigerant antibacterial toothpaste according to any one of claim 6～9, it is characterised in that： Comprise the following steps：After by the NMF, rubbing agent, adhesive, water, foaming agent, sweetener, high molecular polymer mixing, Keep vacuum in -0.090Mpa～-0.096Mpa, stir 20～50 minutes；Thereafter add the flavoring essence, freshener, Bacteriostatic agent, keeps vacuum in -0.090Mpa～-0.096Mpa, stirs 10～50 minutes, lotion of toothpaste is obtained.