CN106511112B - A kind of persistently refrigerant antibacterial toothpaste and preparation method thereof - Google Patents
A kind of persistently refrigerant antibacterial toothpaste and preparation method thereof Download PDFInfo
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- CN106511112B CN106511112B CN201611147447.7A CN201611147447A CN106511112B CN 106511112 B CN106511112 B CN 106511112B CN 201611147447 A CN201611147447 A CN 201611147447A CN 106511112 B CN106511112 B CN 106511112B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a kind of refrigerant antibacterial compositions, and it includes following components: freshener, bacteriostatic agent and the high molecular polymer that can be complexed with the bacteriostatic agent.The invention also discloses a kind of persistently refrigerant antibacterial toothpaste, and the raw material for preparing of the toothpaste includes: moisturizer, rubbing agent, adhesive, foaming agent, edible essence, water and the composition.Lasting refrigerant antibacterial toothpaste of the invention is when in use, since high molecular polymer has good adhesiveness and film forming, after using toothpaste, remain to make freshener and bacteriostatic agent as high molecular polymer is adhered at oral mucosa, and film is formed, achieve the effect that persistently refrigerant and antibacterial.
Description
Technical field
The invention belongs to field of oral care more particularly to a kind of persistently refrigerant antibacterial toothpaste and preparation method thereof.
Background technique
Halitosis refers to from oral cavity or other cavitys full of air such as nose, nasal sinus, pharynx, the foul smell peculiar smell given out,
It affects the normal of people and associates and exchange, and affects itself social image and mental health.One recent investigation is aobvious
Showing, disease incidence of the halitosis in Chinese population has reached 27.5%, and the patient that pathogenic factor belongs to oral cavity intrinsic factor accounts for 80~
90%.Mouth source property halitosis mainly decomposes the substances such as sulfur-containing amino acid, peptide and protein by oral cavity bacterium corruption, generation
Caused by volatile sulfur compounds and fatty acid with peculiar smell.Therefore, halitosis can be generated by removing for mouth source property halitosis
Pathogenic microorganism and its toxin generated and directly remove smelly class chemical compound gas in oral cavity rapidly and inhibit halitosis, it is pure and fresh
Implication.
Currently, having done numerous studies in terms of fresh breath, inhibition halitosis.For example, application No. is " CN931060702 "
Patent of invention disclose the refrigerant effect of collaboration of the compositions such as menthol, N-Ethyl-p-menthane-3-carboxamide, menthone glycerol ketals and its simple
Using.Authorization Notice No. is that the patent of invention of " CN1124126C " elaborates that the combined application of menthol and its derivative can obtain
The cooling effect of collaboration.Application publication number is that the patent of invention of " CN0577837 A " refers to a kind of coolant compositions by gathering
Glutamic acid and oil-soluble freshener composition, under the action of polyglutamic acid, the release time of freshener is extended.Shen Qing Publication
It number refers to go to eliminate bad breath using cyclodextrin, Gantrez AN-119, tea polyphenols etc. for the patent of invention of " CN104257544 A ".
Authorization Notice No. be " CN102512337 B " patent of invention refer to polyvinylpyrrolidone, polypropylene copolymer etc. with it is double
Chlorhexidine, dodecyl benzyl dimethyl ammonium chloride, cetylpyridinium chloride use, and extend the antibacterial time.
In techniques disclosed above, in the utilization for being related to freshener, collaboration can be played by having studied freshener and being applied in combination
Effect enhances refrigerant degree, but is lacking in refrigerant persistence, also there is the research for extending persistence using polyglutamic acid,
But as basic daily chemical product, the price of polyglutamic acid is higher, and unsuitable basis daily necessities industrialization needs；It is related to bacteriostatic agent
Utilization when, have the research that high molecular polymer and bacteriostatic agent are used in conjunction, but above only to chlorhexidine, dodecyl dimethyl benzyl
The superpower effect bacteriostatic agent such as ammonium chloride and plant extracts tea polyphenols are studied, and the research of bacteriostatic agent is proposed to the present invention
It is lacking.
Summary of the invention
On the one hand, it is provided a kind of persistently refrigerant it is an object of the invention to overcome the shortcomings of the prior art place
Antibacterial composition, composition of the invention more can rationally control industrialization cost, make as combined by selecting suitable component
With more cheap high molecular polymer, freshener and the bacteriostatic agent of mature industrialization, extend the refrigerant degree of product and fungistatic effect.
The technical solution adopted by the present invention are as follows: a kind of persistently refrigerant antibacterial composition, it includes following components: refrigerant
Agent, bacteriostatic agent and the high molecular polymer that can be complexed with the bacteriostatic agent.
As further improvement to above-mentioned technical proposal, according to parts by weight, the dosage of each component are as follows: freshener 0.2
~4 parts, 0.01~4 part of bacteriostatic agent and 0.1~20 part of high molecular polymer.
The freshener can be selected from peppermint derivative, as further improvement to above-mentioned technical proposal, the freshener
Including menthol (2- isopropyl -5- methyl cyclohexanol), menthyl lactate (2 hydroxy propanoic acid -5- methyl -2- isopropyl hexamethylene
Ester), N-Ethyl-p-menthane-3-carboxamide (N- ethyl-is to menthyl -3- formamide), menthyl acetate (acetic acid -5- methyl -2- isopropyl hexamethylene
Ester), menthone glycerol ketals (6- isopropyl -9- methyl-1,4- dioxy spiral shell (4,5)-decane -2- methanol), WS-23 (N, 2,3-
Trimethyl -2- butanamide), in WS-5 (N- (ethoxycarbonylmethyl group)-is to alkane -3- formamide) and their derivative
It is at least one；
As further improvement to above-mentioned technical proposal, the bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic
Ag+, at least one of cetylpyridinium chloride and Dialkyl dimethyl ammonium chloride class (such as Quaternium 24).
It is highly preferred that the bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic Ag+, cetylpyridinium chloride and double alkyl two
At least two in ammonio methacrylate class.
As further improvement to above-mentioned technical proposal, the high molecular polymer include acrylic copolymer (such as
Polyacrylate) and vinyl-based copolymer (such as polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer).More
Preferably, the high molecular polymer be polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer mixture,
Wherein, polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer weight ratio are 1~100:1~100.
On the other hand, the application that the present invention also provides compositions as described above in oral-cavity cleaning products.
Another aspect, the present invention also provides a kind of persistently refrigerant antibacterial toothpaste, and the raw material for preparing of the toothpaste includes:
Moisturizer, rubbing agent, adhesive, foaming agent, edible essence, water and compositions as described above.
As further improvement to above-mentioned technical proposal, by weight percentage densimeter, the toothpaste includes following system
Standby raw material: moisturizer 23~72%, rubbing agent 12~60%, adhesive 1~4%, foaming agent 1.5~6%, edible essence 0.8
~2%, composition 0.31~28%, surplus are water.
As further improvement to above-mentioned technical proposal, the raw material for preparing also includes sweetener.Preferably, the sweet tea
Taste agent includes at least one of saccharin sodium, stevioside, Sucralose.
As further improvement to above-mentioned technical proposal, the moisturizer include sorbierite, polyethylene glycol, propylene glycol,
At least one of glycerol.
As further improvement to above-mentioned technical proposal, the rubbing agent includes silica, calcium carbonate, calcium monohydrogen phosphate
At least one of.
As further improvement to above-mentioned technical proposal, described adhesive includes sodium carboxymethylcellulose (CMC), xanthan
At least one of glue, carragheen.
As further improvement to above-mentioned technical proposal, the foaming agent includes lauryl sodium sulfate, moon silicic acid flesh
At least one of propylhomoserin sodium, Cocoamidopropyl betaine, alkyl glycosides.
In another aspect, the present invention also provides the preparation methods of above-described persistently refrigerant antibacterial toothpaste, including with
Lower step: after the moisturizer, rubbing agent, adhesive, water, foaming agent, sweetener, high molecular polymer are mixed, keep true
Reciprocal of duty cycle stirs 20~50 minutes in -0.090 Mpa~-0.096Mpa；Thereafter the edible essence, freshener, antibacterial is added
Agent keeps vacuum degree in -0.090 Mpa~-0.096Mpa, stirs 10~50 minutes, lotion is made.
Compared with the existing technology, the invention has the benefit that
1) present invention is on the basis of being applied in combination freshener, connected applications industry-wide and more cheap macromolecule
Polymer can extend the time of cooling effect, adapt to Market Consumer demand on the basis of enhancing freshener cool degree；
2) present invention studies target bacteriostatic agent combination high molecular polymer application, good in high molecular polymer
Adhesiveness and film forming promotion under, extend the bacteriostasis time of bacteriostatic agent, in conjunction with by compounding bacteriostatic agent, play
Better fungistatic effect has preferable promotion in the economic profit of enterprise and the safety in utilization of consumer.
3) freshener and bacteriostatic agent mix well in high molecular polymer toothpaste is made after, bacteriostatic agent can be multiple with macromolecule
It closes object to be complexed, when using toothpaste, since high molecular polymer has good adhesiveness and film forming, is using toothpaste
Afterwards, it remains to make freshener and bacteriostatic agent as high molecular polymer is adhered at oral mucosa, and forms film, reach persistently clear
Cool and antibacterial effect.
Specific embodiment
The embodiment provides a kind of compositions, and it includes following components: freshener, bacteriostatic agent and can be with
The high molecular polymer that the bacteriostatic agent is complexed.
Wherein, according to parts by weight, the dosage of each component are as follows: 0.2~4 part of freshener, 0.01~4 part of bacteriostatic agent and high score
0.1~20 part of sub- polymer.
The freshener can be selected from peppermint derivative, it is preferable that the freshener includes menthol (2- isopropyl -5- first
Cyclohexanol), menthyl lactate (2 hydroxy propanoic acid -5- methyl -2- isopropyl cyclohexyl), (N- ethyl-is to peppermint for N-Ethyl-p-menthane-3-carboxamide
Base -3- formamide), menthyl acetate (acetic acid -5- methyl -2- isopropyl cyclohexyl), menthone glycerol ketals (6- isopropyl -
9- methyl-1,4- dioxy spiral shell (4,5)-decane -2- methanol), WS-23 (N, 2,3- trimethyl -2- butanamide), WS-5
At least one of (N- (ethoxycarbonylmethyl group)-is to alkane -3- formamide) and their derivative.In order to improve cooling effect,
Increase refrigerant degree, it is preferable that the freshener is selected from following combination: (1) mixture of menthol and N-Ethyl-p-menthane-3-carboxamide, wherein thin
The weight ratio of the pure and mild N-Ethyl-p-menthane-3-carboxamide of lotus is 1~20:1~20；(2) mixture of menthol and menthone glycerol ketals, wherein thin
The weight ratio of the pure and mild menthone glycerol ketals of lotus is 1~20:1~20.
The bacteriostatic agent includes o- cymene -5- alcohol, nano-silver ionic Ag+, (such as two is pungent for Dialkyl dimethyl ammonium chloride class
At least one of base alkyl dimethyl ammonium chloride) and cetylpyridinium chloride.Preferably, the bacteriostatic agent is o- cymene -5-
Alcohol, nano-silver ionic Ag+At least one of.Wherein, o- cymene -5- alcohol is not belonging to cationic germicide, and its feature exists
In its sterilization mode, there is efficient penetrating power, plaque can be infiltrated through, kill oral cavity pathogen；Nanometer Ag+It can be strong
Ground attracts the sulfydryl (- SH) in bacterial body on protease to make protease loss of activity rapidly together with it, causes thin
Bacterium is dead.After bacterium is killed by Ag+, Ag+ is contacted by separate out in bacterium corpse, then with other bacterium colonies again, again and again
It proceeds as described above, is the mechanism that silver sterilizes persistent sterilization, so Ag+ is more efficient.
Preferably, the bacteriostatic agent is o- cymene -5- alcohol, nano-silver ionic Ag+, cetylpyridinium chloride and double alkane
At least two mixing of base alkyl dimethyl ammonium chloride class.It has been investigated that after two or more bacteriostatic agents are rationally used in compounding, in high score
Under the action of sub- polymer, more preferable more longlasting fungistatic effect is had.
The high molecular polymer includes acrylic copolymer (such as polyacrylate) and vinyl-based copolymer (as gathered
Vinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer).Preferably, the high molecular polymer is polyethylene pyrrole
Pyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer mixture, wherein polyvinylpyrrolidone and methyl ethylene
Ether-maleic acid glycosides copolymer weight ratio is 1~100:1~100.Test proves polyvinylpyrrolidone and methyl ethylene
Ether-maleic acid glycosides polymer combination using effect is substantially better than the effect that the two is used alone.
The application that the embodiments of the present invention also provide compositions as described above in oral-cavity cleaning products, such as in tooth
Application in cream.
The embodiments of the present invention also provide a kind of persistently refrigerant antibacterial toothpaste, and the raw material for preparing of the toothpaste includes:
Moisturizer, rubbing agent, adhesive, foaming agent, edible essence, water and compositions as described above.
Wherein, densimeter, the toothpaste prepare raw material comprising following by weight percentage: moisturizer 23~72%, friction
Agent 12~60%, adhesive 1~4%, foaming agent 1.5~6%, edible essence 0.8~2%, composition 0.31~28%, surplus
For water.
In a specific embodiment, the raw material for preparing also includes sweetener.Preferably, the sweetener includes saccharin
At least one of sodium, stevioside, Sucralose.
The moisturizer includes at least one of sorbierite, polyethylene glycol, propylene glycol, glycerol；In order to further increase
The stability of lotion of toothpaste, it is preferable that the moisturizer be sorbierite, polyethylene glycol and propylene glycol mixture, and sorbierite,
The weight ratio of polyethylene glycol and propylene glycol is 20-50:1-10:2-12.
The rubbing agent includes at least one of silica, calcium carbonate, calcium monohydrogen phosphate.
Described adhesive includes at least one of sodium carboxymethylcellulose (CMC), xanthan gum, carragheen.
The foaming agent includes lauryl sodium sulfate, moon silicic acid sodium sarcosinate, Cocoamidopropyl betaine, alkyl sugar
At least one of glycosides.
In one preferred embodiment, a kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, it is described
The raw material for preparing of toothpaste includes:
Sorbierite 20%-35%
Polyethylene glycol-8 1%-10%
Glycerol 2%-12%
Sodium carboxymethylcellulose 0.8%-2%
Carragheen 0.8%-2%
Lauryl sodium sulfate 1%-3%
Sodium lauroyl sarcosine 0.5%-2.5%
Calcium carbonate 38%-52%
Silica 2%-8%
Polyacrylate 0.1%-10%
Saccharin sodium 0.1%-0.3%
O- cymene -5- alcohol 0.01%-0.1%
Menthol 0.1%-2%
N-Ethyl-p-menthane-3-carboxamide 0.1%-2%
Essence 0.8%-2%
Deionized water surplus.
In another preferred embodiment, a kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, institute
The raw material for preparing for stating toothpaste includes:
Sorbierite 20%-50%
Polyethylene glycol-8 1%-10%
Propylene glycol 2%-12%
Sodium carboxymethylcellulose 0.8%-2%
Xanthan gum 0.2%-2%
Lauryl sodium sulfate 1%-3%
Cocoamidopropyl betaine 0.5%-3%
Silica 1 2%-30%
Polyvinylpyrrolidone 0.1%-10%
Methyl vinyl ether-maleic acid glycosides copolymer 0.1%-10%
Saccharin sodium 0.1%-0.3%
Sucralose 0.1%-0.3%
Titanium dioxide 0.1%-1%
Ag+0.1%-2%
Menthol 0.1%-2%
Menthone glycerol ketals 0.1%-2%
Essence 0.8%-2%
Deionized water surplus.
In another preferred embodiment, a kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, institute
The raw material for preparing for stating toothpaste includes:
Sorbierite 20%-50%
Polyethylene glycol-8 1%-10%
Propylene glycol 2%-12%
Sodium carboxymethylcellulose 0.8%-2%
Xanthan gum 0.2%-2%
Lauryl sodium sulfate 1%-3%
Cocoamidopropyl betaine 0.5%-3%
Silica 1 2%-30%
Polyvinylpyrrolidone 0.1%-10%
Methyl vinyl ether-maleic acid glycosides copolymer 0.1%-10%
Saccharin sodium 0.1%-0.3%
Sucralose 0.1%-0.3%
Titanium dioxide 0.1%-1%
Cetylpyridinium chloride 0.1%-2%
Ag+0.1%-2%
Menthol 0.1%-2%
Menthone glycerol ketals 0.1%-2%
Essence 0.8%-2%
Deionized water surplus.
It is including following the embodiments of the present invention also provide the preparation method of above-described persistently refrigerant antibacterial toothpaste
Step: it after moisturizer described above, rubbing agent, water, foaming agent, adhesive, high molecular polymer, sweetener are mixed, keeps
Vacuum degree stirs 20~50 minutes in -0.090 Mpa~-0.096Mpa；Thereafter the edible essence, freshener, antibacterial is added
Agent keeps vacuum degree in -0.090 Mpa~-0.096Mpa, stirs 10~50 minutes, lotion of toothpaste is made.
Above-described freshener and bacteriostatic agent mix well in high molecular polymer toothpaste is made after, bacteriostatic agent can be with
Polymer composite is complexed, when using toothpaste, since high molecular polymer has good adhesiveness and film forming,
After toothpaste, remains to make freshener and bacteriostatic agent as high molecular polymer is adhered at oral mucosa, and form film, reach
To persistently refrigerant and antibacterial effect.
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, the raw material for preparing of the toothpaste includes:
Sorbierite 20%
Polyethylene glycol-8 5%
Glycerol 6%
Sodium carboxymethylcellulose 0.8%
Carragheen 2%
Lauryl sodium sulfate 1%
Sodium lauroyl sarcosine 2.5%
Calcium carbonate 52%
Silica 2%
Polyacrylate 0.1%
Saccharin sodium 0.1%
O- cymene -5- alcohol 0.01%
Menthol 0.1%
N-Ethyl-p-menthane-3-carboxamide 2%
Essence 0.8%
Deionized water surplus；
Wherein, sorbierite, polyethylene glycol-8, glycerol be moisturizer, sodium carboxymethylcellulose, carragheen be binder, ten
Sodium dialkyl sulfate, sodium lauroyl sarcosine are foaming agent, and calcium carbonate, silica are rubbing agent, and polyacrylate is high score
Sub- polymer, saccharin sodium are sweetener, and o- cymene -5- alcohol is bacteriostatic agent, and menthol, N-Ethyl-p-menthane-3-carboxamide are freshener.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment, comprising the following steps: by moisturizer, rubbing agent,
After water, foaming agent, adhesive, high molecular polymer, sweetener mixing, keeps vacuum degree in -0.090Mpa, stir 50 minutes；
Thereafter the edible essence, freshener, bacteriostatic agent is added, keeps vacuum degree in -0.090 MpaMpa, stirs 50 minutes, be made
Lotion of toothpaste.
Embodiment 2
A kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, the raw material for preparing of the toothpaste includes:
Sorbierite 35%
Polyethylene glycol-8 1%
Glycerol 2%
Sodium carboxymethylcellulose 2%
Carragheen 0.8%
Lauryl sodium sulfate 3%
Sodium lauroyl sarcosine 0.5%
Calcium carbonate 38%
Silica 5%
Polyacrylate 5%
Saccharin sodium 0.3%
O- cymene -5- alcohol 0.05%
Menthol 2%
N-Ethyl-p-menthane-3-carboxamide 0.1%
Essence 2%
Deionized water surplus；
Wherein, sorbierite, polyethylene glycol-8, glycerol be moisturizer, sodium carboxymethylcellulose, carragheen be binder, ten
Sodium dialkyl sulfate, sodium lauroyl sarcosine are foaming agent, and calcium carbonate, silica are rubbing agent, and polyacrylate is high score
Sub- polymer, saccharin sodium are sweetener, and o- cymene -5- alcohol is bacteriostatic agent, and menthol, N-Ethyl-p-menthane-3-carboxamide are freshener.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment, comprising the following steps: by moisturizer described above,
After rubbing agent, water, foaming agent, adhesive, high molecular polymer, sweetener mixing, keep vacuum degree in -0.096Mpa, stirring
20 minutes；Thereafter the edible essence, freshener, bacteriostatic agent is added, keeps vacuum degree in -0.096Mpa, stirs 10 minutes, system
Obtain lotion of toothpaste.
Embodiment 3
A kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, the raw material for preparing of the toothpaste includes:
Sorbierite 22%
Polyethylene glycol-8 7%
Glycerol 2%
Sodium carboxymethylcellulose 1%
Carragheen 1%
Lauryl sodium sulfate 2%
Sodium lauroyl sarcosine 1%
Calcium carbonate 40%
Silica 8%
Polyacrylate 10%
Saccharin sodium 0.2%
O- cymene -5- alcohol 0.1%
Menthol 0.3%
N-Ethyl-p-menthane-3-carboxamide 0.3%
Essence 1%
Deionized water surplus；
Wherein, sorbierite, polyethylene glycol-8, glycerol be moisturizer, sodium carboxymethylcellulose, carragheen be binder, ten
Sodium dialkyl sulfate, sodium lauroyl sarcosine are foaming agent, and calcium carbonate, silica are rubbing agent, and polyacrylate is high score
Sub- polymer, saccharin sodium are sweetener, and o- cymene -5- alcohol is bacteriostatic agent, and menthol, N-Ethyl-p-menthane-3-carboxamide are freshener.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment, comprising the following steps: by moisturizer described above,
After rubbing agent, water, foaming agent, adhesive, high molecular polymer, sweetener mixing, keep vacuum degree in -0.093 Mpa, stirring
30 minutes；Thereafter the edible essence, freshener, bacteriostatic agent is added, keeps vacuum degree in -0.093 Mpa, stirs 30 minutes,
Lotion of toothpaste is made.
Embodiment 4
A kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, the raw material for preparing of the toothpaste includes:
Sorbierite 50%
Polyethylene glycol-8 1%
Propylene glycol 2%
Sodium carboxymethylcellulose 0.8%
Xanthan gum 2%
Lauryl sodium sulfate 1%
Cocoamidopropyl betaine 3%
Silica 1 2%
Polyvinylpyrrolidone 5%
Methyl vinyl ether-maleic acid glycosides copolymer 1 0%
Saccharin sodium 0.3%
Sucralose 0.1%
Titanium dioxide 0.1%
Ag+2%
Menthol 0.1%
Menthone glycerol ketals 2%
Essence 0.8%
Deionized water surplus；
Wherein, sorbierite, polyethylene glycol-8, propylene glycol are moisturizer, and sodium carboxymethylcellulose, xanthan gum are binder,
Lauryl sodium sulfate, Cocoamidopropyl betaine are foaming agent, and silica is rubbing agent, polyvinylpyrrolidone, first
Base vinylether-maleic acid glycosides copolymer is high molecular polymer, and saccharin sodium, Sucralose are sweetener, Ag+For bacteriostatic agent,
Menthol, menthone glycerol ketals are freshener.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 3.
Embodiment 5
A kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, the raw material for preparing of the toothpaste includes:
Sorbierite 20%
Polyethylene glycol-8 10%
Propylene glycol 12%
Sodium carboxymethylcellulose 2%
Xanthan gum 0.2%
Lauryl sodium sulfate 3%
Cocoamidopropyl betaine 0.5%
Silica 30%
Polyvinylpyrrolidone 0.5%
Methyl vinyl ether-maleic acid glycosides copolymer 5%
Saccharin sodium 0.1%
Sucralose 0.3%
Titanium dioxide 1%
Ag+1%
Menthol 1%
Menthone glycerol ketals 1%
Essence 1%
Deionized water surplus；
Wherein, sorbierite, polyethylene glycol-8, propylene glycol are moisturizer, and sodium carboxymethylcellulose, xanthan gum are binder,
Lauryl sodium sulfate, Cocoamidopropyl betaine are foaming agent, and silica is rubbing agent, polyvinylpyrrolidone, first
Base vinylether-maleic acid glycosides copolymer is high molecular polymer, and saccharin sodium, Sucralose are sweetener, Ag+For bacteriostatic agent,
Menthol, menthone glycerol ketals are freshener.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 3.
Embodiment 6
A kind of persistently refrigerant antibacterial toothpaste, by weight percentage densimeter, the raw material for preparing of the toothpaste includes:
Sorbierite 30%
Polyethylene glycol-8 6%
Propylene glycol 10%
Sodium carboxymethylcellulose 1.5%
Xanthan gum 1.2%
Lauryl sodium sulfate 2%
Cocoamidopropyl betaine 2%
Silica 25%
Polyvinylpyrrolidone 0.1%
Methyl vinyl ether-maleic acid glycosides copolymer 1 0%
Saccharin sodium 0.2%
Sucralose 0.2%
Titanium dioxide 0.5%
Ag+0.1%
Menthol 2%
Menthone glycerol ketals 0.1%
Essence 2%
Deionized water surplus；
Wherein, sorbierite, polyethylene glycol-8, propylene glycol are moisturizer, and sodium carboxymethylcellulose, xanthan gum are binder,
Lauryl sodium sulfate, Cocoamidopropyl betaine are foaming agent, and silica is rubbing agent, polyvinylpyrrolidone, first
Base vinylether-maleic acid glycosides copolymer is high molecular polymer, and saccharin sodium, Sucralose are sweetener, Ag+For bacteriostatic agent,
Menthol, menthone glycerol ketals are freshener.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 3.
Embodiment 7
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to bacteriostatic agent is cetylpyridinium chloride, and
Its dosage is except 2%, remaining is the same as embodiment 4.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 4.
Embodiment 8
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to bacteriostatic agent is cetylpyridinium chloride, and
Its dosage is except 1%, remaining is the same as embodiment 5.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 5.
Embodiment 9
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to bacteriostatic agent is cetylpyridinium chloride, and
Its dosage is except 0.1%, remaining is the same as embodiment 6.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 6.
Embodiment 10
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to bacteriostatic agent is Ag+With hexadecyl pyrrole
The mixture of pyridine, and the sum of dosage of the two is except 2%, remaining is the same as embodiment 4.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 4.
Embodiment 11
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to bacteriostatic agent is Ag+With hexadecyl pyrrole
The mixture of pyridine, and the sum of dosage of the two is except 1%, remaining is the same as embodiment 5.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 5.
Embodiment 12
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to bacteriostatic agent is Ag+With hexadecyl pyrrole
The mixture of pyridine, and the sum of dosage of the two is except 0.1%, remaining is the same as embodiment 6.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 6.
Embodiment 13
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to high molecular polymer is polyvinylpyrrolidine
Ketone, and its dosage is except 5.5%, remaining is the same as embodiment 5.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 5.
Embodiment 14
The lasting refrigerant antibacterial toothpaste of the present embodiment prepares raw material in addition to high molecular polymer is methyl vinyl ether-
Maleic acid glycosides copolymer, and its dosage is except 5.5%, remaining is the same as embodiment 5.
The preparation method of the lasting refrigerant antibacterial toothpaste of the present embodiment is the same as embodiment 5.
Embodiment 15
Lasting refrigerant antibacterial toothpaste made from embodiment 1~14 is placed on baking oven 3 months of 50 DEG C, sample stability
Normally, physical and chemical index is without exception, and sample fragrance and room temperature sample are almost the same.In 3 months, high temp samples and room temperature sample each side
Face is all almost the same, and general stability is good, complies with the national standard requirements.
Toothpaste effect test
By toothpaste made from Examples 1 to 3 and blank sample, (in addition to without polyacrylate, remaining proportion is the same, few
Amount is filled in water) refrigerant degree duration running is carried out, test method is to select crowd 60 more sensitive to cool degree, according to
Following standard degree persistence refrigerant to toothpaste scores.
Refrigerant degree persistence evaluation criterion
Effect data
From the results, it was seen that with the help of high molecular polymer polyacrylate, toothpaste made from Examples 1 to 3
Refrigerant persistence, which has, to be obviously improved.
By toothpaste made from embodiment 4~6 and blank sample (except without polyvinylpyrrolidone, methyl vinyl ether-horse
Come outside sour glycosides copolymer, remaining proportion is the same, and few amount is filled in water), toothpaste carries out antibacterial hold made from embodiment 7~9
Degree test long, test method is to select 150 oral cavity gingivitis patients, is randomly divided into 3 groups, and one group uses embodiment 4~6
Toothpaste obtained, one group uses blank sample toothpaste, last group is using toothpaste using toothpaste made from embodiment 7~9
Afterwards, (it is with porphyromonas gingivalis, Fusobacterium nucleatum, Candida albicans, Prevotella intermedia, lactobacillus acidophilus to oral cavity flora
Monitoring objective) it was monitored every 2 hours, it monitors 12 hours altogether, data are as follows:
From the results, it was seen that in high molecular polymer polyvinylpyrrolidone, methyl vinyl ether-maleic acid glycosides copolymerization
Under the action of object, the toothpaste sample of the less pbz polymer polymer of toothpaste made from embodiment 4~9 is in bacteriostasis property persistence
There is obvious promotion, and can also find out from toothpaste made from embodiment 10~12, in high molecular polymer polyethylene
Under the action of pyrrolidones, methyl vinyl ether-maleic acid glycosides copolymer, it is used in compounding bacteriostatic agent Ag+And hexadecyl
Ag is used alone in pyridine comparison+When, bacteriostasis property is more preferably more longlasting.
As space is limited, the bacteriostasis rate of each embodiment is not listed in upper table one by one, the bacteriostasis rate in upper table is respectively to implement
Toothpaste made from the average bacteriostasis rate of toothpaste made from example 4~9, the average bacteriostasis rate of blank control group and embodiment 10~12
Average bacteriostasis rate.According to test result, the fungistatic effect of embodiment 10 is significantly better than embodiment 4 and 7, embodiment 11 it is antibacterial
Significant effect is better than embodiment 5 and 8, and the fungistatic effect of embodiment 12 is significantly better than embodiment 6 and 9, and uses average bacteriostasis rate
The result of expression is consistent.
In addition, test proves that persistently the using effect of refrigerant antibacterial toothpaste is better than 13 He of embodiment made from embodiment 5
The effect of lasting refrigerant antibacterial toothpaste made from embodiment 14, the lasting refrigerant refrigerant degree of antibacterial toothpaste made from embodiment 5
Duration is longer, and bacteriostasis rate is higher under comparable conditions.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (8)
1. a kind of persistently refrigerant antibacterial composition, it is characterised in that: include following components: freshener, bacteriostatic agent and can
The high molecular polymer being complexed with the bacteriostatic agent；
According to parts by weight, the dosage of each component are as follows: 0.2~4 part of freshener, 0.01~4 part of bacteriostatic agent and high molecular polymer
0.1~20 part；The bacteriostatic agent includes nano-silver ionic Ag+And cetylpyridinium chloride；
The high molecular polymer be polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer mixture,
In, polyvinylpyrrolidone and methyl vinyl ether-maleic acid glycosides copolymer weight ratio are 1~100:1~100.
2. composition according to claim 1, it is characterised in that: the freshener includes menthol, menthyl lactate, thin
At least one of lotus amide, menthyl acetate, menthone glycerol ketals, WS-23, WS-5.
3. lasting refrigerant antibacterial composition is in preparing oral-cavity cleaning products described according to claim 1~any one of 2
Application.
4. it is a kind of persistently refrigerant antibacterial toothpaste, it is characterised in that: the raw material for preparing of the toothpaste includes: moisturizer, rubbing agent,
Adhesive, foaming agent, edible essence, water and composition according to any one of claims 1 to 2.
5. persistently refrigerant antibacterial toothpaste according to claim 4, it is characterised in that: densimeter by weight percentage, institute
It states toothpaste and prepares raw material comprising following: moisturizer 23~72%, rubbing agent 12~60%, adhesive 1~4%, foaming agent 1.5~
6%, edible essence 0.8~2%, composition 0.31~28%, surplus are water.
6. persistently refrigerant antibacterial toothpaste according to claim 5, it is characterised in that: the raw material for preparing also includes sweet taste
Agent.
7. it is according to claim 4 persistently refrigerant antibacterial toothpaste, it is characterised in that: the moisturizer include sorbierite,
At least one of polyethylene glycol, propylene glycol, glycerol；
The rubbing agent includes at least one of silica, calcium carbonate, calcium monohydrogen phosphate；
Described adhesive includes at least one of sodium carboxymethylcellulose, xanthan gum, carragheen；
The foaming agent include lauryl sodium sulfate, sodium lauroyl sarcosine, Cocoamidopropyl betaine, in alkyl glycosides
At least one.
8. the preparation method of lasting refrigerant antibacterial toothpaste according to any one of claim 4~7, it is characterised in that:
The following steps are included: after the moisturizer, rubbing agent, adhesive, water, foaming agent, sweetener, high molecular polymer are mixed,
It keeps vacuum degree in -0.090MPa~-0.096MPa, stirs 20~50 minutes；Thereafter be added the edible essence, freshener,
Bacteriostatic agent keeps vacuum degree in -0.090MPa~-0.096MPa, stirs 10~50 minutes, lotion of toothpaste is made.
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| JP7180611B2 (en) * | 2017-11-30 | 2022-11-30 | ライオン株式会社 | oral composition |
| CN107929128A (en) * | 2017-12-06 | 2018-04-20 | 成都顺发消洗科技有限公司 | A kind of hotel toothpaste special |
| CN108096049A (en) * | 2018-01-18 | 2018-06-01 | 胡茵 | Toothpaste containing amino acid surfactant and cationic bacteriostatic agent and preparation method thereof |
| CN109481360A (en) * | 2018-09-05 | 2019-03-19 | 上海全力日用品有限公司 | Whitening type pure plant nano silver healthy mouth toothpaste |
| CN111000747B (en) * | 2018-12-31 | 2021-06-15 | 美釉(西安)生物技术有限公司 | Mineralized material for preventing enamel demineralization and application thereof |
| JP2022062930A (en) * | 2020-10-09 | 2022-04-21 | ライオン株式会社 | Dentifrice composition |
| CN112353709A (en) * | 2020-11-04 | 2021-02-12 | 广州市盛龙口腔清洁用品有限公司 | Toothpaste compounded with mint freshener |
| WO2022160228A1 (en) * | 2021-01-29 | 2022-08-04 | Yimin Sun | Mucus adhesion drug delivery |
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