JP2012144490A - Composition for external application - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for external application blended with glycyrrhetinic acid and a derivative thereof, to enhance remarkably an anti-inflammatory effect.SOLUTION: The composition for the external application is blended with one kind or more selected from the group comprising mono-fatty acid polyethylene glycols and tri-fatty acid polyoxyethylene sorbitanes having an 18C fatty acid in its molecule, and the glycyrrhetinic acid and the derivative thereof. Further, the anti-inflammatory effect of the composition for the external application is enhanced by containing one kind or more selected from the group comprising compounds having the 18C fatty acid in its molecule, out of the mono-fatty acid polyethylene glycols and the tri-fatty acid polyoxyethylene sorbitanes, in the composition for the external application blended with the one kind or more selected from the group comprising the glycyrrhetinic acid and the derivative thereof.

Description

  The present invention relates to a composition for external use having excellent anti-inflammatory activity, in which a specific compound having glycyrrhetinic acid or a derivative thereof and a fatty acid having 18 carbon atoms in the molecule is blended. More specifically, it has an excellent anti-inflammatory effect by blending at least one selected from the group consisting of mono-fatty acid polyethylene glycol having 18 carbon atoms in the molecule and tri-fatty acid polyoxyethylene sorbitan with glycyrrhetinic acid or a derivative thereof. The present invention relates to a composition for external use.

  Glycyrrhetinic acid and its derivatives are widely used in external compositions because of their anti-inflammatory activity. However, since the anti-inflammatory effect of an external composition containing these glycyrrhetinic acids and salts thereof is not sufficient, proposals for realizing a higher anti-inflammatory effect have been made. For example, techniques for blending lignan glycosides (Patent Documents 1 and 2), techniques for blending plant extracts such as apple extract, acerola extract, and camcam extract (Patent Documents 3 to 5), p-methoxysilicate Examples include a compound containing a cinnamate compound (Patent Document 6), phytic acid and a salt thereof, and (Patent Document 7).

  However, none of the techniques can enhance the anti-inflammatory effect of the composition until it is sufficiently satisfied, and the problems have not been solved yet.

JP-A-10-279464 Japanese Patent Laid-Open No. 10-279468 Japanese Patent Laid-Open No. 9-291011 JP 2000-212032 A JP 2001-31580 A Japanese Patent Laid-Open No. 62-267216 JP-A-9-183718

  This invention makes it a subject to provide the composition for external use which mix | blended glycyrrhetic acid and its derivative (s), and raised the anti-inflammatory effect notably.

  As a result of intensive studies in view of such circumstances, the present inventors have surprisingly been selected from the group consisting of mono fatty acid polyethylene glycol and tri fatty acid polyoxyethylene sorbitan having a fatty acid having 18 carbon atoms in the molecule. It has been found that an external composition having an extremely excellent anti-inflammatory effect can be obtained by blending one or more with glycyrrhetinic acid or a derivative thereof, and the present invention has been completed.

That is, this invention provides the composition for external use of the following items 1-6 especially.
Item 1.
Contains at least one selected from the group consisting of mono-fatty acid polyethylene glycol and tri-fatty acid polyoxyethylene sorbitan selected from the group consisting of compounds having 18 fatty acids in the molecule and glycyrrhetinic acid and derivatives thereof The composition for external use characterized by doing.
Item 2.
Item 2. The composition for external use according to Item 1, wherein the glycyrrhetinic acid and its derivative are β-glycyrrhetinic acid and a salt thereof.
Item 3.
Item 3. The topical composition according to any one of Items 1 and 2, wherein the mono-fatty acid polyethylene glycol having a fatty acid having 18 carbon atoms in the molecule is polyethylene glycol monooleate or polyethylene glycol monostearate. object.
Item 4.
Item 3. The composition for external use according to any one of Items 1 and 2, wherein the tri-fatty acid polyoxyethylene sorbitan having a fatty acid having 18 carbon atoms in the molecule is polyoxyethylene sorbitan tristearate.
Item 5.
Item 5. The external composition according to any one of Items 1 to 4, wherein the external composition is an oral composition.
Item 6.
In an external composition containing at least one selected from the group consisting of glycyrrhetinic acid and its derivatives, a group consisting of a compound having a fatty acid having 18 carbon atoms in its molecule among mono-fatty acid polyethylene glycol and tri-fatty acid polyoxyethylene sorbitan The method of improving the anti-inflammatory effect of an external composition by containing 1 or more types chosen from.

  The composition for external use of the present invention can obtain an excellent anti-inflammatory effect by significantly enhancing the anti-inflammatory activity of glycyrrhetinic acid and its derivatives.

  The composition for external use according to the present invention is one or more selected from the group consisting of mono-fatty acid polyethylene glycol and tri-fatty acid polyoxyethylene sorbitan having a fatty acid having 18 carbon atoms in the molecule, and a group consisting of glycyrrhetinic acid and its derivatives. It contains at least one selected from the above.

  The mono-fatty acid polyethylene glycol having a fatty acid having 18 carbon atoms in the molecule for use in the present invention is an esterified product of a fatty acid having 18 carbon atoms and polyethylene glycol, specifically, polyethylene glycol monostearate, Examples include polyethylene glycol monooleate, polyethylene glycol monolinoleate, and polyethylene glycol monolinolenate. Among these, polyethylene glycol monostearate and polyethylene glycol monooleate are preferable, and polyethylene glycol monooleate is most preferable. 4-20 are preferable and, as for the addition mole number of polyethyleneglycol, 6-10 are more preferable. The mono-fatty acid polyethylene glycol having a fatty acid having 18 carbon atoms in the molecule can usually be added in an amount of 0.001 to 15% by mass with respect to the total amount of the external composition of the present invention. It is preferably 01 to 3% by mass, more preferably 0.05 to 3% by mass, and most preferably 0.1 to 2% by mass. If it is less than 0.001% by mass, the desired effect may not be obtained. On the other hand, if it exceeds 15% by mass, the scent and taste of the composition are impaired, which is not preferable.

  The tri-fatty acid polyoxyethylene sorbitan having in the molecule thereof a fatty acid having 18 carbon atoms used in the present invention is an esterified product of a fatty acid having 18 carbon atoms and polyoxyethylene sorbitan. Examples include polyoxyethylene sorbitan acid, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan trilinoleate, and polyoxyethylene sorbitan trilinolenic acid. Among these, polyoxyethylene sorbitan tristearate and polyoxyethylene sorbitan trioleate are preferable, and polyoxyethylene sorbitan tristearate is most preferable. The added mole number of polyoxyethylene is preferably 4-30, more preferably 10-25, and most preferably 15-25. The tri-fatty acid polyoxyethylene sorbitan having such a fatty acid having 18 carbon atoms in the molecule can usually be blended in an amount of 0.001 to 10% by mass with respect to the total amount of the composition for external use of the present invention. 0.01-3 mass% is preferable, 0.05-3 mass% is more preferable, 0.1-2 mass% is the most preferable. If the amount is less than 0.001% by mass, the desired effect may not be obtained. On the other hand, if it exceeds 10% by mass, the scent and taste of the composition may be impaired.

  Specific examples of glycyrrhetinic acid or a derivative thereof used in the present invention include glycyrrhetinic acid, a salt thereof, stearyl glycyrrhetic acid, 3-succinyloxyglycyrrhetinic acid, glycyrrhetinic acid glucuronide, and glyceryl retinoic acid glycerin. Among these, glycyrrhetinic acid and its salt are preferable. Such glycyrrhetinic acid and derivatives thereof can usually be blended in an amount of 0.001 to 5.0 mass%, preferably 0.005 to 0.5 mass%, based on the total amount of the external composition of the present invention. 0.02-0.5 mass% is more preferable, and 0.05-0.4 mass% is most preferable. If the amount is less than 0.001% by mass, the desired effect may not be obtained, while if it exceeds 5.0% by mass, the effect may be saturated.

  The composition for external use of the present invention is preferably a composition for oral cavity that relieves, treats or prevents inflammation in the oral cavity. Although not particularly limited, the oral composition in the present invention includes toothpaste, liquid toothpaste, liquid toothpaste, gel toothpaste, mouthwash, gel agent, pasta agent, spray agent, gum agent, and soft paste agent. It can be used as a form (dosage form) such as (cream-form preparation), ointment-form preparation, coating agent and the like. Of these, toothpaste, liquid toothpaste, liquid toothpaste, gel toothpaste, mouthwash, pasta agent, soft paste agent, ointment preparation, and coating agent are more preferable.

  The composition for external use of the present invention includes glycyrrhetinic acid and derivatives thereof, monofatty acid polyethylene glycol having a fatty acid having 18 carbon atoms in the molecule, and trifatty acid polyoxyethylene sorbitan in a range not impairing the effects of the present invention. If it exists, you may further mix | blend the component which can be normally mix | blended with an external composition.

  As the surfactant, a nonionic surfactant, an anionic surfactant or an amphoteric surfactant can be blended. Specifically, examples of the anionic surfactant include alkyl sulfate ester salt, polyoxyethylene alkyl ether sulfate ester salt, alkyl phosphate, polyoxyalkyl ether phosphate, fatty acid soap, polyoxyethylene alkyl ether carboxylic acid. Salt, polyoxyethylene alkyl ether sulfate, α-olefin sulfonate, alkyl sulfosuccinate, polyoxyalkyl ether sulfosuccinate, acylamino acid salt, glycerin fatty acid ester sulfate, alkyl ether phosphate, alkyl glutamate, etc. Is mentioned. Examples of the cationic surfactant include monoalkyltrimethylammonium salt, dialkyldimethylammonium salt, and alkylamine salt. Nonionic surfactants include sugar fatty acid ester, fatty acid alkanolamide, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polypropylene alkyl ether, polyoxy Examples include ethylene alkyl phenyl ether, polyoxyethylene hydrogenated castor oil, alkyl glucoside, polyoxyethylene polyoxypropylene block copolymer, and lecithin. Examples of amphoteric surfactants include alkyldimethylaminoacetic acid betaines, fatty acid amidopropyldimethylaminoacetic acid betaines, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaines, alkylsulfobetaines, and alkylbetaines. These surfactants can be used alone or in combination of two or more.

  As abrasives, abrasive silica, calcium hydrogen phosphate, calcium phosphate, tertiary calcium phosphate, tertiary magnesium phosphate, calcium pyrophosphate, hydroxyapatite, insoluble sodium metaphosphate, aluminum silicate, zirconium silicate, calcium silicate, carbonic acid Examples include calcium, magnesium carbonate, magnesium oxide, alumina, aluminum hydroxide, calcium sulfate, polymethyl methacrylate, pumice, bentonite, and synthetic resin. These abrasive | polishing agents can be used individually or in combination of 2 or more types.

  As binders, carboxymethylcellulose sodium, carboxymethylethylcellulose salt, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, ethylcellulose, crystalline cellulose, crystalline cellulose, crystalline cellulose, carmellose sodium and other microbial products such as xanthan gum Molecules, tragacanth gum, karaya gum, arabic gum, carrageenan, dextrin, agar, pectin, pullulan, gellan gum, locust bean gum, natural alginate such as sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, polyvinyl methyl ether, Synthetic polymers such as sodium polyacrylate, thickening Rica, inorganic binder, such as Veegum, cationic caking agent such as chloride O- [2- hydroxy-3- (trimethylammonio) propyl] hydroxyethyl cellulose and the like. These binders can be used alone or in combination of two or more.

  As a flavoring agent, menthol, carvone, methyl salicylate, vanillin, benzyl succinate, methyl eugenol, anethole, limonene, ocimene, n-decyl alcohol, methyl acetate, citronenyl acetate, cineol, ethyl linalool, vanillin, thyme, Nutmeg, cinnamic aldehyde, benzaldehyde, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento oil, tea tree oil , Tabana oil, star anise oil, fennel oil, diatom oil, basil oil and the like. These fragrance | flavors can be used individually or in combination of 2 or more types.

  Sweeteners include saccharin, saccharin sodium, acesulfame potassium, stevia extract, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, saumatine, aspartylphenylalanine methyl ester, methoxycinnamic aldehyde, palatinose, palatinit, erythritol, maltitol , Xylitol, lactitol and the like. These sweeteners can be used alone or in combination of two or more.

  Examples of the wetting agent / hydrotrope include ethanol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, isoprene glycol, glycerin, diglycerin, sorbit, and polyethylene glycol. These can be used alone or in combination of two or more.

  Examples of the conditioning agent include silicone derivatives, cation-modified water-soluble polymers, fatty acid esters, trimethylglycine, protein hydrolysates, amino acids and derivatives thereof, urea, phospholipids, glycolipids, ceramides, and the like. These can be used alone or in combination of two or more.

  Other components include animal and plant oils and fats, powders, preservatives and preservatives, pigments, pH adjusters, ultraviolet absorbers, animal and plant extracts, and the like.

  Examples of the present invention will be described below, but the present invention is not limited to the following examples. In the following, “%” means “mass%” unless otherwise specified.

Anti-inflammatory effect THP-1 cells (human acute monocytic leukemia-derived cells) are added with 100 nM PMS (manufactured by Sigma), seeded in 24 well plates at 5 × 10 ^ 5 cells / well, and cultured for 48 hours. Differentiation was induced in macrophages. After confirming that the cells adhered to the plate, the medium was replaced with a 1% FBS-contaminated medium (manufactured by Sigma) and cultured for 24 hours. 1 mL of a diluted analyte solution diluted 5000 times with a liquid medium (RPMI1640, manufactured by Sigma) was added to the cells, and after 2 hours, the diluted analyte solution was removed, and then the cells were stimulated with lipopolysaccharide. Supernatant was collected 24 hours after stimulation, and the amount of TNF-α was measured by ELISA. In the blank, a liquid medium was used instead of the diluted specimen liquid. The inflammation suppression rate was calculated using the following formula, and the anti-inflammatory effect was determined according to the following. The obtained results are shown in Table 1.
Inflammation inhibition rate (%) = (100− (TNF-α amount at the time of subject addition) / (blank TNF-α amount)) × 100
Anti-inflammatory effect: Inflammation suppression rate 40% or more ◎
30% or more and less than 40% ○
Less than 30% ×

  Using the composition shown in Table 2 as the subject, the inflammation suppression rate was calculated in the same manner as in the above method to determine the anti-inflammatory effect. The obtained results are shown in Table 2.

  As shown in Tables 1 and 2, polyethylene glycol monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan tristearate and polyoxyethylene sorbitan trioleate have the effect of enhancing the anti-inflammatory effect of glycyrrhetinic acid I found out that In particular, it has been found that polyethylene glycol monooleate and polyethylene glycol monostearate have a strong effect.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In the following, “%” means “mass%” unless otherwise specified.

Example 18 Toothpaste
Component Amount β-glycyrrhetinic acid 0.2
Polyethylene glycol monooleate (10E.O.) 2.0
Sorbit liquid (70%) 30.0
Calcium hydrogen phosphate for dentifrice 15.0
Anhydrous calcium hydrogen phosphate 10.0
Propylene glycol 2.0
Polyoxyethylene hydrogenated castor oil (60E.O.) 2.0
Hydroxyethyl cellulose 1.2
Titanium oxide 0.8
Sodium monofluorophosphate 0.7
Hydroxypropyl methylcellulose 0.2
Tocopherol acetate 0.1
Cetylpyridinium chloride 0.05
Triclosan 0.02
Isopropyl methylphenol 0.05
Saccharin sodium 0.3
Paraben 0.3
Fragrance 1.0
Purified water balance 100.0

Example 19 Toothpaste
Component Amount β-glycyrrhetinic acid 0.2
Polyethylene glycol monooleate (10E.O.) 0.8
Sorbit liquid (70%) 30.0
Silicic anhydride 20.0
Hydroxyapatite 5.0
Sodium carboxymethylcellulose 1.2
Sucrose fatty acid ester 1.0
Aluminum lactate 0.2
Mica titanium 0.2
Methylparaben 0.2
Monoammonium glycyrrhizinate 0.05
Pyridoxine hydrochloride 0.05
Hinokitiol 0.04
Sucralose 0.02
Benzethonium chloride 0.01
Purified water balance 100.0

Example 20 Toothpaste
Component Amount β-glycyrrhetinic acid 0.2
Polyethylene glycol monooleate (10E.O.) 0.1
Erythritol 40.0
Silicic anhydride 15.0
Reduced palatinose 2.0
Xanthan gum 1.5
Light anhydrous silicic acid 1.0
Crystalline cellulose 1.0
Polyoxyethylene stearyl ether (7E.O.) 1.0
Sodium fluoride 0.2
Dextranase 0.2
Methylparaben 0.2
Gunjo Pink 0.2
Polyoxyethylene lauryl ether (5E.O.) 0.1
Benzalkonium chloride 0.01
Purified water balance 100.0

Example 21 Toothpaste
Component Amount β-glycyrrhetinic acid 0.2
Polyethylene glycol monooleate (10E.O.) 0.01
Concentrated glycerin 40.0
Polyethylene glycol 600 10.0
Silica anhydride 10.0
Sodium chloride 5.0
Zeolite 3.0
Sodium alginate 1.5
Palm oil fatty acid amidopropyl betaine 0.6
Crystalline cellulose / Carmellose sodium 0.3
Lysozyme chloride 0.2
Sodium ascorbate 0.05
Copper chlorophyllin sodium 0.05
Green No. 3 0.002
Yellow No. 4 0.002
Purified water balance 100.0

Example 22 Toothpaste
Component Amount β-glycyrrhetinic acid 0.1
Polyethylene glycol monooleate (6E.O.) 1.5
Sorbit liquid (70%) 20.0
Silicic anhydride 12.0
Concentrated glycerin 10.0
Hydrous silica 5.0
Potassium nitrate 5.0
Gellan gum 1.0
Hydroxypropyl cellulose 0.5
Polyoxyethylene sorbitan monooleate (10E.O.) 0.5
Polyglycerin fatty acid ester 0.5
Magnesium sulfate 0.5
Titanium oxide 0.4
Polyoxyethylene (3)
Disodium lauryl sulfosuccinate 0.3
Birch extract 0.3
l-Menthol 0.1
Peonies extract 0.1
Cetylpyridinium chloride 0.05
Sodium polyphosphate 0.05
Oat extract 0.02
Purified water balance 100.0

Example 23 Toothpaste
Component Amount β-glycyrrhetinic acid 0.1
Polyethylene glycol monooleate (6E.O.) 0.02
Sorbit liquid (70%) 30.0
Heavy calcium carbonate 25.0
Light calcium carbonate 5.0
Polyethylene glycol 400 3.0
Sodium carboxymethylcellulose 1.5
Sodium lauryl sulfate 1.0
Chlorhexidine hydrochloride 0.05
Lauroylmethyl taurine sodium 0.5
Gunjo 0.5
Sodium benzoate 0.2
Stevia extract 0.1
Allantoin 0.05
ε-aminocaproic acid 0.05
Toki soft extract 0.01
Purified water balance 100.0

Example 24 Toothpaste
Component Amount β-glycyrrhetinic acid 0.05
Polyethylene glycol monooleate (16E.O.) 0.1
Aluminum hydroxide 30.0
Concentrated glycerin 20.0
Xylitol 5.0
1,3-butylene glycol 3.0
Lauryl glucoside 1.5
Sodium lauroyl glutamate 1.0
Carrageenan 1.0
Sodium polyacrylate 0.3
Tocopherol nicotinate 0.2
Potassium sorbate 0.2
Zinc oxide 0.1
Dipotassium glycyrrhizinate 0.1
Lauroyl sarcosine sodium 0.1
Tranexamic acid 0.05
Dihydrocholesterol 0.05
Purified water balance 100.0

Example 25 Toothpaste
Component Amount β-glycyrrhetinic acid 0.1
Polyethylene glycol monooleate (16E.O.) 0.1
Dentifrice Calcium Hydrogen Phosphate 35.0
Sorbit liquid (70%) 30.0
Silica anhydride 2.0
Propylene glycol 2.0
Sodium carboxymethylcellulose 1.0
Sodium lauryl sulfate 1.0
Sodium monofluorophosphate 0.7
Polyvinylpyrrolidone 0.2
Carboxyvinyl polymer 0.1
Cetylpyridinium chloride 0.05
Triclosan 0.02
Titanium oxide 0.2
Disodium hydrogen phosphate 0.12
2-alkyl-N-carboxymethyl-n-
Hydroxyethylimidazolinium betaine 0.05
Sodium dihydrogen phosphate 0.01
Purified water balance 100.0

Example 26 Toothpaste
Component Amount β-glycyrrhetinic acid 0.1
Polyethylene glycol monooleate (20E.O.) 0.5
Sorbit liquid (70%) 30.0
Silicic anhydride 15.0
Concentrated glycerin 5.0
Lauryl glucoside 2.0
Silylated silica 1.0
Crystalline cellulose 1.0
Hydroxyethyl cellulose 1.0
Propylene glycol 1.0
Polyethylene glycol 4000 1.0
Titanium oxide 0.5
O- [2-hydroxy-3- (trimethylammonio) chloride
Propyl] hydroxyethylcellulose 0.2
Sodium fluoride 0.2
Disodium hydrogen citrate 0.12
Cetylpyridinium chloride 0.05
Dipotassium glycyrrhizinate 0.02
Stearyldimethylbenzylammonium chloride 0.01
N-coconut oil fatty acid acyl L-arginine ethyl
DL-pyrrolidonecarboxylate 0.01
Sodium dihydrogen citrate 0.01
Purified water balance 100.0

Example 27 Toothpaste
Component Amount β-glycyrrhetinic acid 0.2
Polyethylene glycol monostearate (10E.O.) 0.5
Dentifrice calcium hydrogen phosphate 25.0
Sorbit liquid (70%) 20.0
Xanthan gum 1.5
Polyoxyethylene hydrogenated castor oil (80E.O.) 1.0
Ethanol 1.0
Methylparaben 0.3
Titanium oxide 0.3
Tocopherol nicotinate 0.2
Saccharin sodium 0.2
Peppermint oil 0.1
Cetylpyridinium chloride 0.05
Fragrance 0.8
Purified water balance 100.0

Example 28 Toothpaste
Component Amount β-glycyrrhetinic acid 0.4
Polyethylene glycol monostearate (6E.O.) 0.05
Sorbit liquid (70%) 40.0
Silicic anhydride 20.0
Polyethylene glycol 400 5.0
Sodium alginate 1.2
Sodium lauryl sulfate 1.0
Titanium oxide 0.4
Cetylpyridinium chloride 0.1
Methylparaben 0.1
Saccharin sodium 0.1
Pyridoxine hydrochloride 0.05
Fragrance 0.9
Purified water balance 100.0

Example 29 Toothpaste
Component Amount β-glycyrrhetinic acid 0.1
Polyethylene glycol monolinoleate (10E.O.) 1.0
Sorbit liquid (70%) 30.0
Silicic anhydride 20.0
Propylene glycol 3.0
Xanthan gum 1.2
Polyoxyethylene hydrogenated castor oil (40E.O.) 1.0
Titanium oxide 0.5
Hydroxypropyl methylcellulose 0.4
Saccharin sodium 0.2
Sodium fluoride 0.2
Cetylpyridinium chloride 0.05
Isopropyl methylphenol 0.05
Fragrance 1.0
Purified water balance 100.0

Example 30 Toothpaste
Component Amount β-glycyrrhetinic acid 0.05
Monolinolenic acid polyethylene glycol (10E.O.) 0.2
Silicic anhydride 20.0
Sorbit liquid (70%) 20.0
Concentrated glycerin 10.0
Sodium alginate 1.2
Sodium lauryl sulfate 1.0
Titanium oxide 0.2
Saccharin sodium 0.2
Methylparaben 0.1
Cetylpyridinium chloride 0.05
Pyridoxine hydrochloride 0.02
Fragrance 0.9
Purified water balance 100.0

Example 31 Toothpaste
Component Amount β-glycyrrhetinic acid 0.1
Polyoxyethylene sorbitan tristearate (20E.O.) 1.0
Dentifrice calcium hydrogen phosphate 20.0
Concentrated glycerin 10.0
Silicic anhydride 5.0
Propylene glycol 5.0
Erythritol 5.0
Crystalline cellulose carmellose sodium 2.0
Lauroylmethyl taurine sodium 1.0
Sodium monofluorophosphate 0.7
Sodium lauryl sulfate 0.5
Saccharin sodium 0.1
Triclosan 0.02
Tranexamic acid 0.02
Titanium oxide 0.2
Sodium hydroxide 0.005
Blue No. 1 0.001
Fragrance 0.5
Purified water balance 100.0

Example 32 Gel for oral cavity
Component Amount β-glycyrrhetinic acid 0.1
Polyethylene glycol monooleate (4E.O.) 0.5
Concentrated glycerin 50.0
Polyethylene glycol 400 1.0
Hydroxyethyl cellulose 0.5
Hydroxypropyl methylcellulose 0.5
Polyoxyethylene hydrogenated castor oil (60E.O.) 0.5
Sodium fluoride 0.2
Fragrance 0.2
Saccharin sodium 0.1
Cetylpyridinium chloride 0.05
Sodium citrate 0.03
Stearyldimethylbenzylammonium chloride 0.01
N-coconut oil fatty acid acyl L-arginine ethyl
DL-pyrrolidonecarboxylate 0.05
Green No. 3 0.001
Purified water balance 100.0

Example 33 Gel for oral cavity
Component Amount β-glycyrrhetinic acid 0.4
Polyethylene glycol monostearate (10E.O.) 1.0
Concentrated glycerin 20.0
Sorbit liquid (70%) 20.0
Potassium nitrate 5.0
Aluminum lactate 2.0
Lauryl glucoside 1.0
Sodium monofluorophosphate 0.7
Sodium carboxymethylcellulose 0.5
Sodium lauryl sulfate 0.3
Xanthan gum 0.3
Saccharin sodium 0.2
Pyridoxine hydrochloride 0.05
Cetylpyridinium chloride 0.03
Green No. 3 0.001
Fragrance 0.5
Purified water balance 100.0

Example 34 Oral Gel
Component Amount β-glycyrrhetinic acid 0.02
Polyoxyethylene sorbitan tristearate (10E.O.) 0.1
Concentrated glycerin 20.0
Sorbit liquid (70%) 20.0
Potassium nitrate 5.0
Aluminum lactate 2.0
Lauryl glucoside 1.0
Sodium polyacrylate 0.5
Sodium lauryl sulfate 0.3
Tocopherol nicotinate 0.2
Saccharin sodium 0.2
Tragant gum 0.2
Pyridoxine hydrochloride 0.05
Cetylpyridinium chloride 0.03
Green No. 3 0.001
Fragrance 0.5
Purified water balance 100.0

Example 35 Liquid Dentifrice
Component Amount β-glycyrrhetinic acid 0.02
Polyethylene glycol monostearate (10E.O.) 0.05
Concentrated glycerin 10.0
Ethanol 7.0
Polyoxyethylene hydrogenated castor oil (60E.O.) 0.2
Cetylpyridinium chloride 0.05
Triclosan 0.05
Saccharin sodium 0.01
pH adjuster appropriate amount perfume 0.25
Purified water balance 100.0

Example 36 Liquid Dentifrice
Component Amount β-glycyrrhetinic acid 0.05
Polyethylene glycol monooleate (10E.O.) 0.1
Concentrated glycerin 10.0
Ethanol 7.0
Polyoxyethylene hydrogenated castor oil (40E.O.) 0.5
Tocopherol nicotinate 0.2
Cetylpyridinium chloride 0.05
Saccharin sodium 0.01
pH adjuster appropriate amount perfume 0.20
Purified water balance 100.0

Claims (6)

  Contains at least one selected from the group consisting of mono-fatty acid polyethylene glycol and tri-fatty acid polyoxyethylene sorbitan selected from the group consisting of compounds having 18 fatty acids in the molecule and glycyrrhetinic acid and derivatives thereof The composition for external use characterized by doing.   The external composition according to claim 1, wherein the glycyrrhetic acid and its derivative are β-glycyrrhetinic acid and a salt thereof. Mono-fatty acid polyethylene glycol having a fatty acid having 18 carbon atoms in the molecule,
The composition for external use according to any one of claims 1 and 2, wherein the composition is polyethylene glycol monooleate or polyethylene glycol monostearate.   The composition for external use according to any one of claims 1 and 2, wherein the tri-fatty acid polyoxyethylene sorbitan having a fatty acid having 18 carbon atoms in the molecule is polyoxyethylene sorbitan tristearate.   The external composition according to any one of claims 1 to 4, wherein the external composition is an oral composition.   In an external composition containing at least one selected from the group consisting of glycyrrhetinic acid and its derivatives, a group consisting of a compound having a fatty acid having 18 carbon atoms in its molecule among mono-fatty acid polyethylene glycol and tri-fatty acid polyoxyethylene sorbitan The method of improving the anti-inflammatory effect of an external composition by containing 1 or more types chosen from. Containing at least one selected from the group consisting of mono-fatty acid polyethylene glycol and tri-fatty acid polyoxyethylene sorbitan having 18 fatty acids in the molecule and at least one selected from the group consisting of glycyrrhetinic acid and derivatives thereof A featured external composition.