CN107375016A - Dentifrice composition and preparation method thereof - Google Patents
Dentifrice composition and preparation method thereof Download PDFInfo
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- CN107375016A CN107375016A CN201710598003.3A CN201710598003A CN107375016A CN 107375016 A CN107375016 A CN 107375016A CN 201710598003 A CN201710598003 A CN 201710598003A CN 107375016 A CN107375016 A CN 107375016A
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- dentifrice composition
- peppermint
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a kind of dentifrice composition, wetting agent including 6 25wt%, 0.4 1.6wt% adhesive and diluent are surplus, also include 2 5wt% friction-type silica, 5 15wt% thickening type silica, 5 15wt% mixed type silica and 5 10wt% calcium phosphate, and the sodium lauroyl sarcosine of the lauryl sodium sulfate including 2 2.5wt%, 1 2.5wt% glycine betaine and 1 2wt% in the dentifrice composition.Present invention also offers the preparation method of above-mentioned dentifrice composition.Dentifrice composition provided by the present invention, matched by using compound friction agent, wetting agent, composite foamable agent, adhesive and diluent for raw material and suitably, so that the dentifrice composition being prepared not only has the stability required by general toothpaste, and there is the excellent effect for removing bacterial plaque, and the advantages of the foam quality of product is significantly improved.
Description
Technical field
The invention belongs to oral health technical field, and in particular to a kind of dentifrice composition and preparation method thereof.
Background technology
Toothpaste is the dental care product with toothbrush together teeth surfaces, is generally lived by rubbing agent, NMF, surface
Property agent, thickener, sweetener, preservative, active additive, and pigment, essence etc. mix；With people's living standard
Raising, high-tech product is rooted in the hearts of the people, and develops to natural, multi items, multiscale, multifunctional direction, and feature toothpaste into
In order to sell focus.
The product demand of various functions is growing day by day in toothpaste market at present, and turns into the market mainstream, and toothpaste exists
During use, many people always think that the foam of toothpaste is more, quality is better, and its is exactly so in fact when from toothpaste.
Toothpaste is mainly combined by three kinds of rubbing agent, detergent and aromatic compositions.Wherein, the material for determining dirt-removing power is to rub
Liniment；Aromatic makes the effect of toothpaste generation aromatic odor, also bactericidal antiphlogistic；Detergent can produce foam, and this foam can make
Brush the tartar to get off and produce suspension, no longer mutually stick with tooth, finally with mouthwash discharge oral cavity.But detergent has
Lubrication, if its amount is excessive, caused foam can also increase, and lubrication can also increase, and can so reduce and rub on the contrary
The effect of liniment, influence the efficiency to clean the teeth.
And the dentifrice composition of many known function types being in the art present, some of them include oil, such as flavored oils
Or triglyceride oil, we have found that such composition may influence in use to feel to ask due to the oily influence
Topic.Specifically, it has been found that the characteristic of foam may be by bad shadow as caused by the surfactant being present in toothpaste
Ring.
The content of the invention
The defects of existing for prior art, the present invention have supplied a kind of removing bacterial plaque significant effect, and the foam of product
Dentifrice composition that quality significantly improves and preparation method thereof.
The purpose of the present invention is achieved through the following technical solutions：
A kind of dentifrice composition, including 6-25wt% wetting agent, 0.4-1.6wt% adhesive and diluent are remaining
Measure, 2-5wt% friction-type silica, 5-15wt% thickening type silica, 5- are also included in the dentifrice composition
15wt% mixed type silica and 5-10wt% calcium phosphate, and the lauryl sodium sulfate including 2-2.5wt%, 1-
2.5wt% glycine betaine and 1-2wt% sodium lauroyl sarcosine.
Preferably, wherein the wetting agent is the one or more in sorbierite, glycerine, propane diols, polyethylene glycol 400；
Described adhesive is one kind in sodium carboxymethylcellulose, xanthans, hydroxyethyl cellulose, guar gum, carragheen
It is or several；
The diluent is pure water.
Preferably, wherein also including Peppermint essential oil, the Peppermint essential oil is lemon-mint, watermelon ice cream peppermint, water honey
One kind in peach peppermint, tea perfume peppermint, chrysanthemum peppermint, dual thin lotus, mango peppermint, jasmine peppermint, green tea peppermint and salubrious peppermint,
And the dentifrice composition includes 0.1-5wt% Peppermint essential oil.
Preferably, wherein the content of the peppermint in the Peppermint essential oil is not less than 40wt%, and menthol in the peppermint
Content be 40-50wt%.
Preferably, wherein also including 0.1-0.5wt% saccharin sodium in described dentifrice composition.
Present invention also offers the preparation method of above-mentioned dentifrice composition, by the percentage by weight by compound friction
Agent, wetting agent, adhesive, composite foamable agent and diluent mixing, are stirred, particle of milling with 500-800r/min rotating speeds
Footpath obtains lotion of toothpaste to being less than 0.025-0.05mm and being deaerated under 0.06-0.1Mpa vacuum.
Preferably, wherein by the percentage by weight：A, by wetting agent and saccharin sodium, it is put into diluent with 500-
800r/min rotating speeds, which stir, is made the pure aqueous solution, is mixed with compound friction agent, adhesive and composite foamable agent, with 500-
800r/min rotating speeds stir, grain diameter of milling is to less than 0.025-0.05mm and under 0.06-0.1Mpa vacuum
Degassing；B, Peppermint essential oil is added, is stirred with 500-800r/min rotating speeds, grain diameter of milling extremely is less than 0.025-0.05mm
And deaerated under 0.06-0.1Mpa vacuum, obtain lotion of toothpaste.
In the present invention：
No. CAS of saccharin sodium be：128-44-9 (is free of the crystallization water), and 6155-57-3 (contains two crystallizations water), chemical formula：
C6H4SO2NNaCO.2H2O, its chemical name are o-benzoic sulfimide sodium, also known as soluble saccharin, are the salt tolerants of saccharin,
Crystalline powder with two crystallizations water, colourless crystallization or with white, typically contains two crystallizations water, the volatile water that decrystallizes
Into anhydrous saccharin, white powder is odorless or micro- aromatic, and the dense sweet tea band of taste is bitter.Sugariness is 500 times of sucrose or so.It is heat-resisting
Sweet taste is heated and alkali resistance is weak, under acid condition to die down, solution is more than 0.026% bitter, is commonly used in food industry
Synthetic sweetener, and usage history is most long, but is also most controversial synthetic sweetener.The sweetness ratio sucrose sweet tea of saccharin sodium
300-500 times, it is not decomposed, is excreted by kidney in vivo.But its toxicity is not strong, dispute is played mainly in its carcinogenicity,
The sensation that toothpaste causes sweet tea in the sense of taste is mainly to confer in the present invention.
Carragheen (Carrageen, CAS 9000-07-1), also known as antler glue, carrageenan, Irish green moss glue, it is
A kind of general designation of the polysaccharide of the extraction from marine red alga (including Chondrus, Eucheuma, China fir Trentepohlia and husky Lepidium etc.), is more
The mixture of kind material, there is ι (Iota), κ (Kappa), λ (Lamda), four kinds of μ (mu).It is a kind of superior food additive of quality
Add agent, there is strong formation gel and high viscosity characteristic, gratifying elasticity, transparency and dissolubility, stability is very
It is good, also will not water even if heating in medium-sized and alkaline solution even if long-term place will not also reduce its gel strength and viscosity
Solution；, can be with forming interionic phase interaction between positively charged protein molecule with the good property combined with protein
With this unique reactivity is peerless in all colloids.In the present invention, it is mainly used in the adhesive of toothpaste.
PEG-400 is polyethylene glycol 400, and it is liquid, and it has the extensive compatibility with various solvents, is molten well
Agent and solubilizer, it is widely used in liquid preparation, such as oral liquid, eye drops, in of the invention, it is mainly used in toothpaste solubilising
And wetting agent.
Glycerine is also known as glycerine, is colourless sweet clear and bright thick liquid, odorless, have warm sweet taste, and tide can be absorbed from air
Gas, can also absorb hydrogen sulfide, hydrogen cyanide and sulfur dioxide, and relative density 1.26362,17.8 DEG C of fusing point, 290.0 DEG C of boiling point (divide
Solution), index of refraction 1.4746,176 DEG C of flash-point (opening cup), acute toxicity:LD50:31500mg/kg (rat oral), glycerine are
The framework ingredient of triglycerides molecule.In the present invention, its main function is wetting agent and solubilizer as toothpaste, can make tooth
Composition in cream melts rapidly after meeting water, improves the quality of toothpaste.
Sorbierite is D-sorbite, English name Sorbitol, D-Glucitol, Sorbol, D-Sorbitol.Molecular formula is
C6H14O6, molecular weight 182.17, be white hygroscopic powder or crystalline powder, sheet or particle, it is odorless.According to crystallization condition not
Together, fusing point changes in the range of 88~102 DEG C, relative density about 1.49, (1g is dissolved in about 0.45mL water) soluble in water, slightly soluble
In ethanol and acetic acid, there is refrigerant sweet taste, sugariness is about the half of sucrose, and calorific value is close with sucrose.In the present invention, it is mainly made
For wetting agent and antifreezing agent, lotion can be kept to lubricate, it is color and luster, in good taste.
Silica (chemical formula：SiO2) it is a kind of acidic oxide, corresponding hyrate is silicic acid (H2SiO3).Titanium dioxide
Silicon is one of most important compound of silicon, and its chemical property is more stable, not soluble in water also not reacted with water.But for toothpaste
Silica is unformed powder, tasteless, not soluble in water or sour, into chemical inertness, with Fluoride in Toothpaste compound and other raw material phases
Dissolubility is good, and the structure and granularity of silica can be controlled by by working condition, different for the species of toothpaste, produces respectively
Go out：Three kinds of friction type, mixed type, thickening type products.It is the main of toothpaste as long as its rubbing agent as toothpaste in the present invention
Composition, it is that bacterial plaque, soft dirt and swill are easier to be brushed down.Rubbing agent will have certain rubbing action, but not
Facing i.e. periodontium can be damaged.When teeth are brushed, silica is suspended among foam, is filled with oral cavity, is had extensively with tartar
Contact, tartar is easily got off by scrub under the rubbing action of toothbrush, as mouthwash spues.
Calcium phosphate (calcium phosphate, tribasic), chemical constitution this product are multi-form calcium phosphate composition
Mixture.Insoluble in ethanol and acetone, water is slightly soluble in, is soluble in watery hydrochloric acid and nitric acid.It may be used as anticaking agent, acidity adjustment
Agent, nutritional supplement, fumet, stabilizer, water retention agent.In the present invention, it is mainly used in the rubbing agent of toothpaste.
Guar gum, it is macromolecular Natural hydrophilic colloid, food is mainly polymerized to by galactolipin and mannose and formed, belongs to day
One of right galactomannans, quality improver, a kind of natural thickener.Outward appearance is from white to yellowish free-flowing
Powder, can be dissolved in cold water or hot water, meet after water and form colloid substance, the effect of reaching rapid thickening.China《Food additives
Use sanitary standard》Be defined as shining in (GB2760-1996) is needed cautiously with being used in right amount in varieties of food items by production.This
In invention, it is mainly used in the adhesive of toothpaste so that toothpaste has good lubricity, mitigates mill of the rubbing agent to tooth
Damage；In addition, also there is foam humidification, film forming ability and bonding force.
Native cellulose is that the polysaccharide most wide, content is most, source very abundant are distributed in nature.Current fibre element
Modification technology is concentrated mainly on etherificate and the aspect of esterification two.Cellulose obtains carboxymethyl cellulose (CMC) after carboxy methylation, its
The aqueous solution has the effects such as thickening, film forming, gluing, water tariff collection, colloid protection, emulsification and suspension, is widely used in oil, food
The industries such as product, medicine, textile and paper, it is one of most important cellulose ethers.In the present invention, it is mainly used in glycerine shape
Into matrix of the aqueous solution as toothpaste, be a excellent adhesive.
K-12 is lauryl sodium sulfate, belongs to anion surfactant, structural formula CH3(CH2)11OSO3Na, molecular weight
288.39, white is to micro-yellow powder, and micro- have a special gas, apparent density 0.25g/mL, fusing point 180~185 DEG C (decomposition), easily
Water is dissolved in, HLB value is 40. nontoxic, and it is white or faint yellow powdery, is dissolved in water, insensitive to alkali and hard water.With decontamination,
Emulsification and excellent foaming power, its biological degradability>90%.Purposes：As emulsifying agent, extinguishing chemical, foaming agent and textile auxiliary；
Also serve as toothpaste and paste, powdery, shampoo are industrially usually used in detergent and textile industry.Be widely used in toothpaste, shampoo,
Hair cream, shampoo, washing powder, liquid are washed, cosmetics and the plastics demoulding, lubrication and pharmacy, papermaking, building materials, chemical industry etc. are gone
Industry, in the present invention, it is mainly as foaming agent.
Glycine betaine is a kind of alkaline matter, is a kind of zwitterionic surfactant, has cleaning on cosmetics, bubbles, be wet
Profit, bactericidal action.And its effect is determined by the pH value in solution, often it is used together, can reduces with teepol
The excitant of teepol, and can increase the micella particle in solution, thus increase viscosity, it is usually used in having one's hair wash
Essence, bath article, baby cleansing product etc., in the present invention, it is mainly as foaming agent.
Hamposyl L, to weak yellow liquid, there is special odor to be white.It is dissolved in the alcohol solutions such as water, ethanol or glycerine
In.At typical condition, it is all more stable to heat, acid, alkali.In the present invention, because it has superior foaminess and foam
It is fine and smooth, lasting, it is mainly used in the foaming agent of toothpaste.
Peppermint essential oil, mint flavored are clearly cooled off oneself, and the mind rouses oneself.Cure mainly：Throat-clearing throat-moistening, elimination halitosis have good work(
Effect, and have the unique curative effect for body and mind of releiving.In the present invention, it mainly plays fresh breath and body and mind of releiving.
Compared with prior art, the present invention at least has advantages below：
Dentifrice composition provided by the present invention, by using compound friction agent, wetting agent, composite foamable agent, adhesive
And diluent is raw material and suitably matched so that the dentifrice composition being prepared not only has required by general toothpaste
Stability, and there is the excellent effect for removing bacterial plaque, and the advantages of the foam quality of product is significantly improved.
Embodiment
Below in conjunction with specific implementation, the present invention is described in detail.
When stated in the form of scope, preferred scope or preferable numerical upper limits and lower limit some amount, concentration or its
It is worth or when parameter, it should be understood that equivalent to it is specific disclose by by any pair of range limit or preferred value with appointing
Any scope that meaning range lower limit or preferred value combine, without considering whether the scope specifically discloses.Unless refer in addition
Go out, number range value listed herein is in the end points including scope, and all integers and fraction within the scope of this.
Unless otherwise indicated, all percentage herein, number, ratio etc. are by weight.
This paper material, method and embodiment is exemplary, and unless stated otherwise, be should not be construed as restricted
's.
Embodiment 1
The present embodiment provides a kind of dentifrice composition, and raw material components include by weight percentage：
Friction-type silica, 2wt%；
Thickening type silica, 8wt%；
Mixed type silica, 5wt%；
Calcium phosphate, 5wt%；
Wetting agent, 20wt%；
Lauryl sodium sulfate, 2wt%；
Glycine betaine, 1wt%；
Sodium lauroyl sarcosine, 1.5wt%；
Adhesive, 1.6wt%；
Diluent, 53.5wt%；
Peppermint essential oil, 0.4wt%.
Wherein, wherein friction-type silica, thickening type silica, mixed type silica and calcium phosphate are referred to as again
Rubbing agent is closed, lauryl sodium sulfate, glycine betaine and sodium lauroyl sarcosine are referred to as composite foamable agent；The peppermint essence grease separation
Use lemon-mint；The wetting agent is glycerine；Described adhesive is sodium carboxymethylcellulose and guar mixture, and carboxymethyl
The mass ratio of sodium cellulosate and guar gum is 3:2；The diluent is pure water.
Dentifrice composition described further is prepared with the following method, is comprised the following steps that：
By above-mentioned percentage by weight by Peppermint essential oil, compound friction agent, wetting agent, adhesive, composite foamable agent and dilution
Agent mixes, stirred with 600r/min rotating speeds, grain diameter of milling to being less than 0.03mm, and under 0.075Mpa vacuum
Degassing, obtain lotion of toothpaste.
Comparative example 1
Component, proportioning and preparation method in comparative example 1 etc. are same as Example 1, and difference is only to add
Foaming agent lauryl sodium sulfate and rubbing agent are mixed type silica.
Comparative example 2
Component, proportioning and the preparation method of comparative example 2 etc. are same as Example 1, and difference is only to add again
Rubbing agent is closed, and foaming agent only adds lauryl sodium sulfate.
Comparative example 3
Component, proportioning and the preparation method of comparative example 3 etc. are same as Example 1, and difference difference is
Compound friction agent is only added, and foaming agent only adds lauryl sodium sulfate and glycine betaine.
Comparative example 4
Component, proportioning and preparation method in comparative example 4 etc. are same as Example 1, and difference is only to add
Composite foamable agent, and rubbing agent only adds mixed type silica and calcium phosphate.
Embodiment 2
The present embodiment provides a kind of dentifrice composition, and raw material components include by weight percentage：
Friction-type silica, 3.5wt%；
Thickening type silica, 12wt%；
Mixed type silica, 9.5wt%；
Calcium phosphate, 5wt%；
Wetting agent, 12wt%；
Lauryl sodium sulfate, 2.1wt%；
Glycine betaine, 1.5wt%；
Sodium lauroyl sarcosine, 1.7wt%；
Adhesive, 1wt%；
Diluent, 50.2wt%；
Peppermint essential oil, 1.5wt%.
Wherein, the Peppermint essential oil is mango peppermint；The wetting agent is sorbierite；Described adhesive is carboxymethyl cellulose
Plain sodium；The diluent is pure water.
Dentifrice composition described further is prepared with the following method, is comprised the following steps that：
By above-mentioned percentage by weight by Peppermint essential oil, compound friction agent, wetting agent, adhesive, composite foamable agent and dilution
Agent mixes, stirred with 680r/min rotating speeds, grain diameter of milling to being less than 0.03mm, and under 0.08Mpa vacuum
Degassing, obtain lotion of toothpaste.
Embodiment 3
The present embodiment provides a kind of dentifrice composition, and raw material components include by weight percentage：
Friction-type silica, 4wt%；
Thickening type silica, 13wt%；
Mixed type silica, 15wt%；
Calcium phosphate, 8wt%；
Wetting agent, 10wt%；
Lauryl sodium sulfate, 2wt%；
Glycine betaine, 2wt%；
Sodium lauroyl sarcosine, 2wt%；
Adhesive, 1wt%；
Diluent, 40wt%；
Peppermint essential oil, 3wt%.
Wherein, the Peppermint essential oil green tea peppermint；The wetting agent is the mixed of glycerine, propane diols and polyethylene glycol 400
Compound, and the mass ratio of glycerine, propane diols and polyethylene glycol 400 is 1:1:2；The hydroxyethyl cellulose, guar gum and card
The mixture of glue is drawn, and the mass ratio of the hydroxyethyl cellulose, guar gum and carragheen is 2:1:1；The diluent is pure
Water purification.
Dentifrice composition described further is prepared with the following method, is comprised the following steps that：
By above-mentioned percentage by weight by Peppermint essential oil, compound friction agent, wetting agent, adhesive, composite foamable agent and dilution
Agent mixes, stirred with 750r/min rotating speeds, grain diameter of milling to being less than 0.04mm, and under 0.075Mpa vacuum
Degassing, obtain lotion of toothpaste.
Embodiment 4
The present embodiment provides a kind of dentifrice composition, and raw material components include by weight percentage：
Friction-type silica, 5wt%；
Thickening type silica, 10wt%；
Mixed type silica, 12wt%；
Calcium phosphate, 11wt%；
Wetting agent, 14wt%；
Lauryl sodium sulfate, 1.5wt%；
Glycine betaine, 2.3wt%；
Sodium lauroyl sarcosine, 1wt%；
Adhesive, 0.9wt%；
Diluent, 41wt%；
Saccharin sodium, 0.3wt%；
Peppermint essential oil, 1wt%.
Wherein, the Peppermint essential oil selects lemon-mint；The wetting agent is glycerine；Described adhesive is carboxymethyl cellulose
Plain sodium and guar mixture, and the mass ratio of sodium carboxymethylcellulose and guar gum is 3:2；The diluent is pure water.
Dentifrice composition described further is prepared with the following method, is comprised the following steps that：
By the percentage by weight：A, wetting agent and saccharin sodium, it is put into diluent and is stirred with 600r/min rotating speeds
The pure aqueous solution is uniformly made, is mixed with compound friction agent, adhesive and composite foamable agent, it is equal with the stirring of 720r/min rotating speeds
Even, grain diameter of milling deaerates to less than 0.035 and under 0.08Mpa vacuum；B, Peppermint essential oil is added, with 700r/min
Rotating speed stirs, grain diameter of milling is less than 0.025mm and is deaerated under 0.09Mpa vacuum, obtains lotion of toothpaste.
Experimental example
Embodiment 1-4, comparative example the 1-4 dentifrice composition being prepared are gone into dental plaque effect and user to the product
Impression tested, it is specific as follows：
1st, dental plaque effect is gone
1.2nd, method
1.2.1, the test period：60 days
1.2.2, subjects inclusive criteria and exclusion standard
Inclusive criteria：There is creamy white spot problem；Health, and agree to coordinate on time and check；Promise to undertake during experiment daily
Keep using the oral hygiene measures provided, without using other tooth-caring toothpastes；To oral cavity health care products without allergies.
Exclusion standard：Endogenous color spot suffers from tooth；Current long-term use of chemicals；Need to use antibiosis during experiment
Element, immune formulation, gargle etc.；Wear artificial tooth or orthodontic appliance；Need to carry out scaling during experiment, scrape and control, be dental body filled
Deng the treatment of influence index observation.
1.2.3 test specimen
For the tooth-caring toothpaste that embodiment 1-4, comparative example 1-4 are prepared as test specimen, toothbrush is soft bristle tooth brush.
1.2.4 test method
1.2.4.1 experimental design
Using double blinding, Method of Random Test.
1.2.4.2 test index
Examination of mouth is carried out by well-trained Dentist, is finger with each study subject 33,32,31,41,42,43
Tooth is marked, the area to its lingual surface color spot and color are by the classification point-score scoring of Lobene color spots index respectively.To checking before experiment
Person is corrected experiment.
Area standards of grading are as follows：
1- exists without color spot；
2- color spots are no more than the l/3 of facing；
3- color spots are no more than the 2/3 of facing；
4- color spots are more than the 2/3 of facing.
Color area standards of grading are as follows：
1- exists without color spot；
2- is slight color spot (yellow or yellowish-brown)；
3- moderates color spot (moderate brown)；
4- severes color spot (dark-brown or black) color spot is more than the 2/3 of facing).
2.2.4.3 experiment process
Each study subject teeth stains index is recorded, is checked using toothpaste after 4 weeks.
Experiment packet：Screening meets inclusive criteria and exclusion standard person, is divided into embodiment 1-4, comparative example 1-4 by random table
Eight groups, eight groups essentially identical in health, the index creamy white spot order of severity, age, sex ratio.
1.2.5 statistical analysis
In this result of the test, compared in group using 4 weekly datas before and after toothpaste using pairing rank test (Wilcoxon
Signed Ranks Test), the rank test (Mann-Whitney Test) using non-matching data is compared between group.
1.1 result of the test
Share 200 people and complete experimental study, male 176 people, the people of female 24, age 20-58 year.
1.2 interpretation of result
1.2.1 index tooth Lobene color spots Index area classification score result of variations before and after two groups of subject's experiments.
Table 1：Index tooth Lobene color spots Index area classification score change comparison sheet
| Dentifrice composition | Before experiment | After experiment | Difference |
| Embodiment 1 | 15.92 | 12.61 | 3.31 |
| Comparative example 1 | 15.84 | 15.24 | 0.6 |
| Comparative example 2 | 14.81 | 13.91 | 0.9 |
| Comparative example 3 | 15.62 | 13.52 | 2.1 |
| Comparative example 4 | 14.96 | 13.56 | 1.4 |
| Embodiment 2 | 15.21 | 11.3 | 3.91 |
| Embodiment 3 | 15.19 | 9.33 | 5.86 |
| Embodiment 4 | 15.36 | 10.4 | 4.96 |
As seen from Table 1, each subject is used for tartar after using the dentifrice composition of compound friction agent and composite foamable agent
After four weeks, the area discrepancy of subject's index creamy white spot is statistically significant, shows that the area of subject's creamy white spot occurs substantially
Change.Comparative example 1, comparative example 1 and comparative example understand that the area discrepancy of subject's index creamy white spot is not statistically significant,
Prompting use single foaming agent and rubbing agent, and after the single foaming agent of use and the dentifrice composition of compound friction agent,
The area change unobvious of subject's creamy white spot.
2nd, impression of the user to the product
Employ and require 160 panelists to undergo training using 0-10 lineal scale by a series of attributes to institute
State dentifrice composition to be evaluated, every group of 20 people, the average result experienced in the use to the toothpaste is shown in table 2：
Use feeling of the user of table 2 to the product
| Dentifrice composition | Sand type | Bubble amt | Foam quality |
| Embodiment 1 | 0.48 | 6.4 | 8.7 |
| Comparative example 1 | 0.5 | 3.6 | 5.2 |
| Comparative example 2 | 0.51 | 3.5 | 5.6 |
| Comparative example 3 | 0.5 | 4.2 | 6.0 |
| Comparative example 4 | 0.46 | 4.8 | 6.5 |
| Embodiment 2 | 0.56 | 7.2 | 8.4 |
| Embodiment 3 | 0.61 | 8.1 | 8.0 |
| Embodiment 4 | 0.58 | 6.9 | 8.2 |
As shown in Table 2, comparative example 1 and comparative example 1, comparative example 2 are understood, using single foaming agent and rubbing agent,
And using single foaming agent and the dentifrice composition of compound friction agent, influence of the user to its gravel degree is little, still
Its bubble amt and foam quality are had a great influence；By test result indicates that, dentifrice composition provided by the present invention has good
Good bubble amt and foam quality impression, bring the higher-quality foam quality impression of user；
More than, it is only the preferable embodiment of the present invention, but the protection domain invented is not limited thereto, and it is any ripe
Know those skilled in the art the invention discloses technical scope in, the change or replacement that can readily occur in should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be defined by the protection domain of claims.
Claims (7)
- A kind of 1. dentifrice composition, it is characterised in that the adhesive of wetting agent, 0.4-1.6wt% including 6-25wt% and Diluent is surplus, and 2-5wt% friction-type silica, 5-15wt% thickening type two are also included in the dentifrice composition Silica, 5-15wt% mixed type silica and 5-10wt% calcium phosphate, and the dodecyl including 2-2.5wt% The sodium lauroyl sarcosine of sodium sulphate, 1-2.5wt% glycine betaine and 1-2wt%.
- 2. dentifrice composition according to claim 1, it is characterised in that the wetting agent is sorbierite, glycerine, the third two One or more in alcohol, polyethylene glycol 400；Described adhesive is sodium carboxymethylcellulose, xanthans, hydroxyethyl cellulose, guar gum, one kind in carragheen or several Kind；The diluent is pure water.
- 3. dentifrice composition according to claim 1 or 2, it is characterised in that also including Peppermint essential oil, the Peppermint essential oil It is thin for lemon-mint, watermelon ice cream peppermint, honey peach peppermint, tea perfume peppermint, chrysanthemum peppermint, dual thin lotus, mango peppermint, jasmine One kind in lotus, green tea peppermint and salubrious peppermint, and the dentifrice composition includes 0.1-5wt% Peppermint essential oil.
- 4. dentifrice composition according to claims 1 to 3, it is characterised in that the content of the peppermint in the Peppermint essential oil Not less than 40wt%, and the content of menthol is 40-50wt% in the peppermint.
- 5. according to dentifrice composition according to any one of claims 1 to 4, it is characterised in that in described dentifrice composition Also include 0.1-0.5wt% saccharin sodium.
- 6. according to the preparation method of dentifrice composition according to any one of claims 1 to 5, it is characterised in that by described heavy Measure percentage to mix compound friction agent, wetting agent, adhesive, composite foamable agent and diluent, with 500-800r/min rotating speeds Stir, grain diameter of milling extremely is less than 0.025-0.05mm and is deaerated under 0.06-0.1Mpa vacuum, acquisition toothpaste Lotion.
- 7. the preparation method of dentifrice composition according to claim 5, it is characterised in that by the percentage by weight：a、 By wetting agent and saccharin sodium, it is put into diluent to stir with 500-800r/min rotating speeds the pure aqueous solution is made, it is and multiple Rubbing agent, adhesive and composite foamable agent mixing are closed, is stirred with 500-800r/min rotating speeds, grain diameter of milling is to being less than 0.025-0.05mm simultaneously deaerates under 0.06-0.1Mpa vacuum；B, Peppermint essential oil is added, is stirred with 500-800r/min rotating speeds Uniform, grain diameter of milling is mixed to being less than 0.025-0.05mm and being deaerated under 0.06-0.1Mpa vacuum, obtains toothpaste cream Body.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109998975A (en) * | 2019-05-24 | 2019-07-12 | 福建中合医药股份有限公司 | A kind of efficient toothpaste |
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| CN105534749A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Child intelligence benefiting toothpaste |
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|---|---|---|---|---|
| CN1757401A (en) * | 2005-08-05 | 2006-04-12 | 昆明医学院 | Oral nebula contg. Rosmarinus extractive |
| CN101023914A (en) * | 2007-03-23 | 2007-08-29 | 昆明牙膏有限责任公司 | Toothpaste containing notoginseng extract and preparing method |
| CN105055247A (en) * | 2015-08-26 | 2015-11-18 | 昆明牙膏有限责任公司 | Toothpaste with hemostasis and gum protection functions and preparation method of toothpaste |
| CN105534749A (en) * | 2015-12-25 | 2016-05-04 | 名臣健康用品股份有限公司 | Child intelligence benefiting toothpaste |
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| CN109998975A (en) * | 2019-05-24 | 2019-07-12 | 福建中合医药股份有限公司 | A kind of efficient toothpaste |
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