CN105534786A - Special care toothpaste for middle aged and elderly people - Google Patents
Special care toothpaste for middle aged and elderly people Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses special care toothpaste for middle aged and elderly people. The special care toothpaste is prepared from the following raw materials in percentage by weight: 0.1-5 percent of rhodiola rosea extract, 0.1-5 percent of acanthopanax root extract, 0.1-5 percent of rhizoma polygonati extract, 20-50 percent of grinding agent, 20-55 percent of moisturizer, 0.6-1.5 percent of thickener, 0.2-1.5 percent of PVM/MA (Poly Vinyl Methyl-Methyl Acrylate) copolymer, 1.8-3 percent of surfactant, 0.15-0.3 percent of sweetening agent, 0.1-0.4 percent of preservative, 0.5-2 percent of essence and the balance of deionized water. Specific to the body features of the middle aged and elderly people, the toothpaste has a plurality of health care functions of resisting aging, resisting fatigue, resisting stress, preventing three highs, enhancing immunity and the like besides cleaning oral cavity.
Description
Technical field
The present invention relates to a kind of toothpaste, be provide special care to toothpaste according to a kind of person in middle and old age containing Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati extract of person in middle and old age's physical trait development specifically, belong to oral cavity cleaning and nursing field.
Background technology
Middle age is the core force of social construction, and old people is the treasure of society.Middle age is laboured and toil with mind and body in order to cause, conscientiously to do one's duty, bear nervous stress for a long time and cause the Sub-health such as immunity degradation, fatiguability, senilism, in recent years, along with the raising of people's living standard, " three-hypers disease " crowd that eutrophication causes becomes younger just gradually, and the health of middle age in serious threat.The function of each system of old people's health is progressively failing, and is mainly manifested in nervous system sensitivity decrease, hypomnesis, easily tired, immune system immunity degradation, " the three-hypers disease " of blood system and atherosclerosis etc.Based on person in middle and old age's physical condition, so middle-aged and elderly people more needs to provide special care to.
Toothpaste is the first-selection of people's common oral cleaning-nursing, and along with the raising of health of people consciousness, people expect that toothpaste has more health care type to meet different consumers.
In order to meet health care for the middle and old aged demand, develop a kind of person in middle and old age and provide special care to toothpaste, make middle-aged and elderly people just can improve healthy index by oral cavity cleaning approach, there is the feature of easy to use, convenient health care, compensate for middle age be busy with work and cause have no time to keep healthy and old people time and the forgetful deficiency being negligent of keeping healthy.
Toothpaste kind is in the market still more single, mostly concentrate on cleaning teeth or improve certain oral problem, more do not deep-cut other health cares of digging and improving beyond oral problem, more do not have the special person in middle and old age for the healthy feature development of person in middle and old age to provide special care to toothpaste.
Summary of the invention
Order of the present invention is to provide a kind of person in middle and old age and provides special care to toothpaste, according to person in middle and old age's physical trait, Radix Rhodiolae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Polygonati three taste Chinese medicine extract are added in toothpaste, except cleaning oral cavity, have the plurality kinds of health care effects such as defying age, resisting fatigue, compressive resistance, prevention " three-hypers ", enhancing immunity concurrently.
The object of the invention is to be achieved through the following technical solutions:
A kind of person in middle and old age provide special care to toothpaste, and comprise 0.5 ~ 10% active component and 90 ~ 99.5% matrix components, described active component comprises Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Rhizoma Polygonati extract; Described matrix components comprises abrasive, wetting agent, thickening agent, Gantrez AN-119, surfactant, sweeting agent, antiseptic, essence and deionized water.
Toothpaste of the present invention, by weight percentage, the raw material components that described active component comprises: the Radix Rhodiolae extract of 0.1 ~ 5%, the Radix Et Caulis Acanthopanacis Senticosi extract of 0.1 ~ 5%, the Rhizoma Polygonati extract of 0.1 ~ 5%;
The raw material components that described matrix components comprises: the abrasive of 20 ~ 50%, the wetting agent of 20 ~ 55%, the thickening agent of 0.6 ~ 1.5%, the Gantrez AN-119 of 0.2 ~ 1.5%, the surfactant of 1.8 ~ 3%, the sweeting agent of 0.15 ~ 0.3%, the antiseptic of 0.1 ~ 0.4%, the essence of 0.5 ~ 2%, deionized water is added into 100%.
Described Radix Rhodiolae extract extracts from crassulaceae plants Radix Rhodiolae, and through natural extract that is refining, concentrated, drying, main component is rhodioside.There is prophylaxis of tumours, strengthen immunologic function, slow down aging, resisting fatigue, anti-hypoxia, radioprotective, two-ways regulation nervus centralis, the effects such as restoration and protection body.Preferred addition is 0.5 ~ 2%.
Described Radix Et Caulis Acanthopanacis Senticosi extract is a kind of light brown powder extracted from the dry root and rhizome of Araliaceae Radix Et Caulis Acanthopanacis Senticosi, and main component is eleutheroside.Can adjust internal organs QI and blood function, improve blood circulation, enhance metabolism, have resisting fatigue, stimulate immunity of organisms, prevent pressure institute to functions such as diseases, preferred addition is 0.5 ~ 2%.
Described Rhizoma Polygonati extract is a kind of brownish-yellow powder extracted from Rhizoma Polygonati dry rhizome, main component is polygonatum polysaccharide first, second, third and polygonatum rhizome oligosaccharide first, second, the third, has and falls the effect such as " three-hypers ", atherosclerosis, resisting fatigue, immune activation, slow down aging.Preferred addition is 0.5 ~ 2%.
Described abrasive is one or both mixture in calcium carbonate, calcium hydrogen phosphate, silicon dioxide.
Described wetting agent is one or more mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol.
Described thickening agent is one or more mixture in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, guar gum, carrageenan.
Described Gantrez AN-119 can improve active matter residence time in the oral cavity, improves the bioavailability of active matter.
Described surfactant is one or more mixture in sodium laurylsulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl betanin.
Described sweeting agent is one or both mixture in saccharin sodium, acesulfame potassium.
Described antiseptic is one or more mixture in sodium benzoate, methyl hydroxybenzoate, propyl hydroxybenzoate.
Other additive can also be comprised, as tetrasodium pyrophosphate, fluoride, titanium dioxide etc. in above-mentioned toothpaste.
Tool of the present invention has the following advantages and beneficial effect:
1, the present invention is according to the healthy feature of person in middle and old age, first Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Rhizoma Polygonati extract three kinds had the Chinese medicine composite usage of the plurality of health care functions such as defying age, resisting fatigue, compressive resistance, prevention " three-hypers ", enhancing immunity in toothpaste, both the activity of single Chinese medicine had been played, three kinds of Chinese medicinal health-care functions are made again mutually to superpose, Synergistic.With the addition of Gantrez AN-119 in mastic, the adhesive attraction that can produce by means of high molecular polymer and oral mucosa, makes the active component adhered on oral mucosa play a role lastingly, improves the bioavailability of active matter simultaneously.
2, a kind of person in middle and old age of the present invention provide special care to toothpaste, the Chinese medicine health-care active component added can by the effective absorption in the process of brushing teeth and residual absorbant in the oral cavity after brushing teeth, directly enter blood circulation, avoid the first pass effect of liver to active matter, and the Degradation of gastrointestinal enzyme and acid, improve the degree of absorbing of active component, play the health-care effect to person in middle and old age's health better, quickly.
3, person in middle and old age of the present invention provide special care to toothpaste, add the approach of middle-aged and elderly people nourishing healthy, no longer be confined to food or health product, while common oral cleaning-nursing, just can obtain the plurality kinds of health care effects such as defying age, resisting fatigue, compressive resistance, prevention " three-hypers ", enhancing immunity, there is very strong practicality.
4, the invention is intended to solve other functional health problems beyond oral cavity, expand the frontier of toothpaste health care, realize the extensive knowledge and profound scholarship of China's Chinese medicine and the perfect adaptation of oral cavity cleaning and nursing.
Detailed description of the invention
Below the simple statement of the health-care effect of several Chinese medicines that the present invention relates to:
China's first medical science ancient books and records Shennong's Herbal, is classified as in medicine top grade by Radix Rhodiolae, take Radix Rhodiolae and to make light of one's life by commiting suicide QI invigorating, always do not prolong life, and nontoxic many clothes, clothes of a specified duration are not hurted sb.'s feelings.Radix Rhodiolae can transfer all active factors in body, having tonifying for the deficiency, subtracts unnecessary dual regulation, by carrying out self regulation to body metabolism system, blood circulation, nervous system, hormonal system, immune system etc., making body reach optimum state.
Radix Rhodiolae has anti-aging effects, can significantly improve the activity of body SOD (superoxide dismutase), scavenging free radicals, LPO inhibitor.Such as: Rhodiola crenulata extract can improve the activity of rat erythrocyte, liver SOD, and have the trend increasing SOD of heart tissue activity.Red wild flax fly drinks Radix Rhodiolae extracting solution, can obvious life-saving, and the rate of lengthening the life is better than Radix Ginseng.Radix Rhodiolae have the effect promoting 2BS cell proliferation and reduce mortality rate, can suppress the activity of rat cell lipid peroxide and enhancing serum superoxide dismutases.
Radix Rhodiolae has antifatigue effect, and Radix Rhodiolae has cardiotonic, can increase the time that brain and body normal activity continue, and extends the load-bearing capacity of cerebral nerve and body muscle.Strengthen the utilization rate of oxygen, reduce the content of lactic acid and acetone in blood, reduce muscle oxygen amount.During overwork, accelerate the decomposition of fat and protein, increase energy delivery, after overwork, the deposit of Body development and liver glycogen can be increased again.To control fatigue syndrome, people is made to keep vigorous energy and vigor to have obvious effect for a long time.
Radix Rhodiolae has nervous system regulation effect, and Radix Rhodiolae can eliminate the intense strain of people effectively, and well-balanced adjustment nervus centralis, improving water flood and irritated excited or depressive state, improve attention, memory reinforcing, brain-care, prevention senile dementia.
Radix Et Caulis Acanthopanacis Senticosi has another name called Cortex Acanthopancis, is namely regarded as having adding the good medicine that essence mends marrow and anti-aging effects from ancient times.Radix Et Caulis Acanthopanacis Senticosi has antifatigue effect, can stimulate mind & body vigor, enhancing body endurance and ability.Research display eleutheroside can improve the use of motion muscle to oxygen, improves acuity and physics endurance, and the aerobatic exercise that human body can be maintained a more long is also faster to recover from exercise fatigue.
Radix Et Caulis Acanthopanacis Senticosi can prevent pressure institute to disease, and eleutheroside has good effect to adrenal gland, and adrenal gland can secrete the hormone of resisting fatigue.Taking Radix Et Caulis Acanthopanacis Senticosi can advance body to solve from beat exposure to the physical stress of overworking, and disease ability is resisted in enhancing, and comprehensive energy level of human body.Radix Et Caulis Acanthopanacis Senticosi is rehabilitation after being ill, bear too much pressure or anxiety, work excessive cause weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.
Radix Et Caulis Acanthopanacis Senticosi can stimulate immunity of organisms, and research finds that Radix Et Caulis Acanthopanacis Senticosi can stimulate T-cell to produce, and is used to the treatment of panimmunity relevant disease.
Rhizoma Polygonati has another name called Rhizoma Polygonati Cirrhifolii, Caput Gallus domesticus ginseng, is the dry rhizome of liliaceous plant P. kingianum, Rhizoma Polygonati or Polygonatum cyrtonema Hua.There is boosting qi and nourishing yin, spleen invigorating, kidney benefiting functions.
Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, the effects such as atherosclerosis.Rhizoma Polygonati decoct (100%), to experimental cholesterol-fed rabbits gavage, has obvious reducing effect to triglyceride, beta lipoprotein and cholesterolemia.
Rhizoma Polygonati can strengthen immunologic function, and research shows: Rhizoma Polygonati has certain influence to cellular immunization, humoral immunization, can improve lymhocyte transformation rate, is conducive to the formation of antibody.
Rhizoma Polygonati has antifatigue effect, with Rhizoma Polygonati decoct 17.67% concentration 0.3ml/ lumbar injection, can extend mice swimming time.
Set forth the present invention further below by specific embodiment, but the use of these embodiments only for being described in more detail, and shall not be applied to and limit the present invention in any form.Following Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract and Rhizoma Polygonati extract are commercially available prod.
embodiment 1
A kind of person in middle and old age provide special care to toothpaste, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) methyl hydroxybenzoate, propyl hydroxybenzoate, essence are added stirring and dissolving in container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of PEG-4000 pre-dispersed evenly after add remaining PEG-4000 again;
3) deionized water to be added in premix pot in A, then saccharin sodium, acesulfame potassium, sodium lauroyl sarcosine, Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Rhizoma Polygonati extract is added, and stirring and dissolving, then the raw material in container B is added in premix pot 1 stir;
4) sorbitol is added in premix pot B;
5) calcium carbonate, silicon dioxide, sodium carboxymethyl cellulose, guar gum, sodium laurylsulfate are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 2
A kind of person in middle and old age provide special care to toothpaste, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) methyl hydroxybenzoate, butyl hydroxybenzoate, essence are added stirring and dissolving in container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of propylene glycol pre-dispersed evenly after add remaining propylene glycol again;
3) deionized water is added in premix pot A, then saccharin sodium, tetrasodium pyrophosphate, sodium lauroyl glutamate, Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Rhizoma Polygonati extract is added, and stirring and dissolving, then the raw material in container B is added in premix pot 1 stir;
4) glycerol, sorbitol are added in premix pot B;
5) calcium hydrogen phosphate, silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 3
A kind of person in middle and old age provide special care to toothpaste, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) container A is added after being weighed by essence;
2) Gantrez AN-119 is added in container B, with a small amount of Polyethylene Glycol-600 pre-dispersed evenly after add remaining Polyethylene Glycol-600 again;
3) deionized water is added in premix pot A, then saccharin sodium, tetrasodium pyrophosphate, sodium benzoate, methyl hydroxybenzoate sodium, cocoyl betanin, sodium fluoride, Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Rhizoma Polygonati extract is added, and stirring and dissolving, then the raw material in container B is added in premix pot A stir;
4) sorbitol is added in premix pot B;
5) silicon dioxide, sodium carboxymethyl cellulose, carrageenan, sodium laurylsulfate, titanium dioxide are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 4
A kind of person in middle and old age provide special care to toothpaste, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) container A is added after being weighed by essence;
2) Gantrez AN-119 is added in container B, with a small amount of Polyethylene Glycol-600 pre-dispersed evenly after add remaining Polyethylene Glycol-600 again;
3) deionized water is added in premix pot A, then add saccharin sodium, tetrasodium pyrophosphate, sodium benzoate, Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Rhizoma Polygonati extract, and stirring and dissolving, then the raw material in container B is added in premix pot A stir;
4) sorbitol is added in premix pot B;
5) silicon dioxide, sodium carboxymethyl cellulose, carrageenan, sodium laurylsulfate, titanium dioxide are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
clinical trial part
Experimental example 1: mice burden swimming method:
The tired main performance of mice burden swimming is that exercise tolerance declines, exercise tolerance be reflection organism fatigue the most directly, the most objective index.Embodiment one is carried out mouse anti-reflecting fatigue test, to prove that the present invention has resisting fatigue effect.
Laboratory animal and dosage are arranged: Kunming mouse, and male, body weight 18 ~ 22g, is divided into high, medium and low dosage group and water matched group totally 4 groups, and often organizing mice is 15, and high dose group is 20 times of human body recommended amounts; Middle dosage group is 10 times of human body recommended amounts; Low dose group is 5 times of human body recommended amounts.
Swimming test: adopt mice burden swimming method.Continuous per os gives test sample 1 week, after last is to sample 30min, Mus root of the tail portion bears the sheet lead of Mouse Weight 5%, putting into water temperature is 25 DEG C, in the swimming trunk of depth of water 30cm, 5 mices once put into by each water tank, start to exhaust to power the swimming time (min) that the dead time is mice from swimming with stopwatch record.See the following form shown in 1.
Table 1 mice burden swimming time statistical table
| Group | Mice quantity | Walking weight load (min) |
| High dose group | 15 | 105±24.2 |
| Middle dosage group | 15 | 99±10.6 |
| Low dose group | 15 | 92±12.7 |
| Water matched group | 15 | 67±15.8 |
Known by table 1 mice burden swimming time statistical table, the swimming time of experimental mice extends greatly than water matched group swimming time, illustrates that the present invention can extend the walking weight load that can extend mice, and then proves that the present invention has antifatigue effect.
Experimental example 2: enhancing immunity effect assessment of the present invention:
Choose 30 routine hypoimmunities, weather slightly changes middle-older patient easy to catch cold, the toothpaste of the present embodiment two is used every day to brush teeth 2 times, continuous use is after 3 months, the immunity of survey result display patient significantly improves, the people caught a cold and number of times obviously reduce, and illustrate that the present invention has enhancing immunity effect.
Experimental example 3: the evaluation strengthening resistance to compression and anti-aging effects:
Choosing 30 examples because of work and life stress causes the middle age of the senilism features such as psychentonia, hypomnesis, susceptible to lose temper due to restlessness, sexual disorder, the toothpaste of the present embodiment three is used every day to brush teeth 2 times, continuous use is after 3 months, in survey result display above sign phenomenon, some alleviates, some disappears, the mental status is clearly better, and sexual function improves, and senilism phenomenon obviously reduces.Illustrate that the present invention has compressive resistance, anti-aging effects.
Experimental example 4: because of the evaluation of " three-hypers " effect that eutrophy causes
Choose 30 examples because of eutrophy and cause the middle-aged and elderly people of " three-hypers ", the toothpaste of the present embodiment four is used every day to brush teeth 2 times, continuous use is after 3 months, some disappearances of symptom such as dizziness, headache that survey result display causes because of " three-hypers " at ordinary times, uncomfortable in chest, chest pain, numb limbs and tense tendons are unable, some alleviates, and condition is clearly better.Illustrate that the person in middle and old age of the present invention to " three-hypers " have prevention and mitigation.
What the present invention relates to is that a kind of person in middle and old age provide special care to toothpaste, above embodiment is just to limited elaboration of the present invention, and not limitation of the present invention, is not departing under the spirit and scope of the present invention condition, to the amendment that embodiment is done, all belong within the scope of the technology of the present invention.
Claims (9)
1. person in middle and old age provide special care to a toothpaste, comprise 0.5 ~ 10% active component and 90 ~ 99.5% matrix components, it is characterized in that: described active component comprises Radix Rhodiolae extract, Radix Et Caulis Acanthopanacis Senticosi extract, Rhizoma Polygonati extract; Described matrix components comprises abrasive, wetting agent, thickening agent, Gantrez AN-119, surfactant, sweeting agent, antiseptic, essence and deionized water.
2. person in middle and old age according to claim 1 provide special care to toothpaste, it is characterized in that: the raw material components that described active component comprises: the Radix Rhodiolae extract of 0.1 ~ 5%, the Radix Et Caulis Acanthopanacis Senticosi extract of 0.1 ~ 5%, the Rhizoma Polygonati extract of 0.1 ~ 5%;
The raw material components that described matrix components comprises: the abrasive of 20 ~ 50%, the wetting agent of 20 ~ 55%, the thickening agent of 0.6 ~ 1.5%, the Gantrez AN-119 of 0.2 ~ 1.5%, the surfactant of 1.8 ~ 3%, the sweeting agent of 0.15 ~ 0.3%, the antiseptic of 0.1 ~ 0.4%, the essence of 0.5 ~ 2%, deionized water is added into 100%.
3. person in middle and old age according to claim 2 provide special care to toothpaste, it is characterized in that: described Radix Rhodiolae extract extracts from crassulaceae plants Radix Rhodiolae, through natural extract that is refining, concentrated, drying, main component is rhodioside, and its preferred addition is 0.5 ~ 2%.
4. person in middle and old age according to claim 2 provide special care to toothpaste, it is characterized in that: described Radix Et Caulis Acanthopanacis Senticosi extract is a kind of light brown powder extracted from the dry root and rhizome of Araliaceae Radix Et Caulis Acanthopanacis Senticosi, main component is eleutheroside, and preferred addition is 0.5 ~ 2%.
5. person in middle and old age according to claim 2 provide special care to toothpaste, it is characterized in that: described Rhizoma Polygonati extract is a kind of brownish-yellow powder extracted from Rhizoma Polygonati dry rhizome, main component is polygonatum polysaccharide first, second, third and polygonatum rhizome oligosaccharide first, second, the third, and preferred addition is 0.5 ~ 2%.
6. person in middle and old age according to claim 2 provide special care to toothpaste, it is characterized in that: described abrasive is one or both mixture in calcium carbonate, calcium hydrogen phosphate, silicon dioxide;
Described wetting agent is one or more mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol;
Described thickening agent is one or more mixture in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, guar gum, carrageenan;
Described surfactant is one or more mixture in sodium laurylsulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl betanin.
7. person in middle and old age according to claim 2 provide special care to toothpaste, it is characterized in that: described Gantrez AN-119 can improve active matter residence time in the oral cavity, improve the bioavailability of active matter.
8. person in middle and old age according to claim 2 provide special care to toothpaste, it is characterized in that: described sweeting agent is one or both mixture in saccharin sodium, acesulfame potassium; Described antiseptic is one or more mixture in sodium benzoate, methyl hydroxybenzoate, propyl hydroxybenzoate.
9. person in middle and old age according to claim 1 provide special care to toothpaste, it is characterized in that: can also comprise other additive in above-mentioned toothpaste, as tetrasodium pyrophosphate, fluoride, titanium dioxide etc.
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