CN102048666B - Skin care composition with wrinkle removing and resisting function and preparation and preparation method thereof - Google Patents
Skin care composition with wrinkle removing and resisting function and preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a skin care composition with a wrinkle removing and resisting function. The composition comprises a phase A and a phase B, wherein the phase A comprises oil, and the phase B comprises traditional Chinese medicine extracts. In the invention, raw materials are all selected from natural soothing components, have little stimulation to the skin, permeate into the skin stratum basale through various approaches and can be used for recovering skin activity and removing free radicals so as to fundamentally play the roles of removing and resisting wrinkles. Experiments prove that the preparation of the skin care composition has an obvious wrinkle removing function, and can obviously improve the texture of the skin, make the texture fine and smooth, simultaneously enhance skin glossiness and make the skin fin, mellow and white after being used for 30 days. The skin care composition disclosed by the invention is prepared from the raw materials which are easy to obtain by a convenient preparation method, is easy to accept by the massive consumers and has good application prospects and market prospects.
Description
Technical field
The present invention relates to a kind of skin care compositions, specifically a kind of skin care compositions with the crease-resistant effect of wrinkle removal, and by external preparation of said composition preparation and preparation method thereof.
Background technology
Wrinkle is the initial sign of skin aging.Wrinkle further develops, and can form pleat, i.e. darker pleat on the skin.After 25 years old, the ageing process of skin begins, and wrinkle occurs gradually.The order that occurs generally is forehead, goes up palpebra inferior, paropia, ear proparea, cheek, cervical region, following chin, mouthful week.The reason that causes wrinkle to produce is a lot, and from the angle of theory of Chinese medical science, the functional activity of the inherent internal organs of wrinkle and human body is closely related; From the angle of modern medicine, think that then the appearance of wrinkle is relevant with age, histrionic muscles and gravity.When histrionic muscles shrank, skin can shrink and wrinkle occur.Normally, young skin has certain elasticity and tension force, after histrionic muscles was lax, skin can restore very soon, and wrinkle is disappeared.After the people got into the middle age, skin began obviously aging, and thinning of skin, hardening, drying, tension force reduce.Corium elastic fibrosis, fracture reduce the tension force of skin and elasticity, and like this, after histrionic muscles was lax, skin can not restore very soon, and the wrinkle that then makes of a specified duration " solidifies ", and histrionic muscles not shrinkage mark still exists.Increase with the age, skin and subcutaneous tissue are more lax, add the atrophy or the disappearance of top surface portion supporting tissue, and muscle is soft, and the cunning bob will take place under the effect of gravity skin, forms darker wrinkle.
Wrinkle removal product in the market continues to bring out.Many cosmetology skin care productss can only be absorbed by skin surface to a great extent, can not really get into skin corium, reach profound renewal and the purpose that collagen protein is replenished, and play the effect of removing the wrinkle slow down aging.Some cosmetics in order to reach " mystery " effect of quick wrinkle removal, adds hormones or other violated components in playing skin care item, though can reach the wrinkle removal effect fast, for skin health is buried serious hidden danger.
Therefore, working out a kind of skin care item that can desalinate, smooth away wrinkles and have long-acting anti-wrinkle effect is focuses that those skilled in the art study.Add Chinese medicine ingredients in some wrinkle removal skin care item at present; But shortcomings such as Chinese crude drug generally has the ion concentration height, the smell is awful, therefore, the Chinese medicine cosmetics that declare in market are for fear of these shortcomings; Majority all is to add simply or a few flavor Chinese medicine; Therefore addition seldom can't carry out prescription according to traditional traditional Chinese medical science thought, and the wrinkle removal anti-wrinkle effect is also not obvious.
Summary of the invention
The purpose of this invention is to provide a kind of is that primary raw material is used for the skin care compositions that daily skin protection has the crease-resistant effect of wrinkle removal with the Chinese medicine extract.
Another object of the present invention is to propose a kind of skin care formulation that utilizes the above-mentioned composition preparation.
A purpose more of the present invention is to propose the method for preparing of above-mentioned skin care formulation.
For realizing that above-mentioned purpose the present invention invents thinking and is:
The present invention adopts the prescription thought prescription of the traditional Chinese medical science " monarch ", is " monarch " medicine with Chinese medicine extract, plays main wrinkle removal effect; Avenin and collagen protein etc. are " minister " medicine, strengthen the wrinkle removal effect of Chinese medicine extract; With antipruritic and antipruritic agent and penetrating agent etc. is " assistant " medicine, reduces the stimulation of entire product, promotes the absorption of active ingredient; Be " making " medicine with nutrient etc., supplement the nutrients, keep the required nutrition of skin eubolism to skin.Chinese medicine activity extract of the present invention has very strong DPPH radical scavenging activity, has the ability of stronger removing ultra-oxygen anion free radical.Free radical is to cause the key factor that wrinkle forms, and removes too much free radical in the skin, can suppress the formation of wrinkle from the source.Avenin is that protein more than 5000 dalton constitutes by molecular weight, meets albuminous molecular weight ranges.Effect with the skin that compacts immediately can make skin produce instantaneous tight sensation, temporarily smoothes away wrinkles; Collagen protein can directly infiltrate skin bottom, and good with the affinity of surrounding tissue, but helper cell manufactures collagen protein; Impel Skin Cell normally to grow up, can Skin Cell be propped up, in conjunction with preserving moisture and suppressing the effect of wrinkle; Reach jointly and unfold coarse groove, the effect of desalination microgroove.
The present invention selects the Radix Astragali, Radix Ophiopogonis, Radix Pseudostellariae, Radix Salviae Miltiorrhizae and Radix Glycyrrhizae five tastes drug regimen for use, thereby effectively plays the effect of wrinkle removal reduce wrinkle.The brief introduction of five tastes efficacy of drugs is following:
The Radix Astragali: contain sucrose, glucuronic acid, astragalus polysaccharides A, B, C, D, lymphatic temperament, several amino acids, bitter principle, Radix Astragali saponin, choline, folic acid, flavane chemical compound and contain various trace elements such as selenium, silicon, zinc, cobalt, copper, molybdenum.Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.The Radix Astragali has benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Radix Ophiopogonis: effect with replenishing YIN and removing heat, nourishing the lung to arrest cough; Cough, expectorant due to treatment interior-heat caused by deficiency of YIN or consumption of body fluid caused by febrile disease, restlessness and thirst, the dryness-heat impairing the lung is thick, the QI rising in reverse order etc.
Radix Pseudostellariae: root contains fructose, starch, Saponin.It is reported again, contain free amino acid, the highest with arginine, glutamic acid, aspartate content, account for 30%～40% of free amino acid, also contain maltose etc.Radix Pseudostellariae can be used for the lack of appetite asthenia of deficiency-weakness of spleen-QI, deficiency of stomach-Yin.Ability strengthening the spleen gas, nourishing stomach-YIN.Deficiency of the lung cough caused by dryness that also is used for hindering in deficiency of vital energy Tianjin and cardiopalmus sleeplessness, deficiency-heat hyperhidrosis.Can supplementing QI for promoting the production of body fluid.
Radix Salviae Miltiorrhizae: nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly: menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Glycyrrhizae: Radix Glycyrrhizae property is flat, and sweet in the mouth is returned 12 warps.Detoxifcation arranged, eliminate the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.
Inventor of the present invention carries out compatibility with above-mentioned five tastes medicine, and wherein the Radix Astragali has the effect that tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening and diuretic detumescent.Radix Ophiopogonis can YIN nourishing and the production of body fluid promoting, the Radix Pseudostellariae tonifying QI to produce body fluid, and Radix Salviae Miltiorrhizae can blood circulation promoting and blood stasis dispelling and removing heat from blood.Radix Glycyrrhizae benefiting vital QI and blood coordinating the actions of various ingredients in a prescription.The inventor makes up external with said medicine, and proposes the optimum amount of said composition external, makes each medicine produce cooperative effect, and external wrinkle removal anti-wrinkle effect is natural plant wrinkle removal agent very significantly.
Concrete technical scheme of the present invention is following:
A kind of skin care compositions, said compositions with the crease-resistant effect of wrinkle removal comprise A mutually with B mutually, said A comprises oils and fats mutually; Said B comprises Chinese medicine extract mutually.
Said B also comprises one or more in emulsifying agent, amino acid humectant, chelating agen, hydrolysis avenin and the phyto-hyaluronic acid mutually.
Said emulsifying agent is the cetearyl glucoside; Said chelating agen is a disodium EDTA.
B also comprises one or more in glycerol, butanediol, stabilizing agent, stimulation inhibitory factor and the antipruritic and antipruritic agent mutually in the said compositions.
Said oils and fats comprises one or more in cetearyl alcohol, behenyl alcohol, the two stearates of tetramethylolmethane, glyceryl monostearate, squalane, shea butter, dimethicone, water solublity Jojoba oil, vitamin E and the bisabolol.
Said compositions also comprises the C phase, and said C comprises one or more in antiseptic, collagen protein, essence and the sodium hydroxide mutually.
Said each amounts of components is:
A phase: cetearyl alcohol 1～5wt%
Behenyl alcohol 0.5～2wt%
The two stearate 0.5～2wt% of tetramethylolmethane
Glyceryl monostearate 0.5～2wt%
Squalane 3～8wt%
Water solublity Jojoba oil 3～5wt%
Bisabolol 0.1～0.5wt%
B phase: emulsifying agent 1～3wt%
Stabilizing agent 0.1～0.4wt%
Chelating agen 0.05～0.15wt%
Avenin 5～10wt%
Stimulation inhibitory factor 1～5wt%
Antipruritic and antipruritic agent 1～3wt%
Phyto-hyaluronic acid 3～6wt%
Chinese medicine extract 1～5wt%
C phase: antiseptic 0.1～0.5wt%
Essence 0.1～0.3wt%
Sodium hydroxide 0.2～0.5wt%
Surplus is a water.
Said Chinese medicine extract is processed by following weight parts proportion raw material medicine:
10～20 parts of the Radixs Astragali, 10～30 parts of Radix Ophiopogonis, 10～25 parts of Radix Pseudostellariaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 5～20 parts in Radix Glycyrrhizae.
Said Chinese medicine extract is processed according to following method, and concrete steps are:
(1) takes by weighing each crude drug according to said components and consumption;
(2) crude drug is mixed add entry, boil from liquid and constantly pick up counting, boiled 30～180 minutes; The mass volume ratio g/ml of said crude drug and water is 0.5～1: 10～20;
(3) stop heating, be cooled to 30～50 ℃, 100～200 orders filter;
(4) filtrating that obtains of step (3) through 500～700 order vacuum filtrations, vacuum is 0.05～0.1MPa, promptly prepares Chinese medicine extract again.
A kind of method for preparing above-mentioned skin care compositions, said method step is following:
(1) takes by weighing each raw material by above-mentioned component and consumption;
(2) A being heated to 80～85 ℃ of stirrings respectively with B mutually mutually makes material dissolution complete;
(3) A is added to stirring (stir speed (S.S.) is 50～100 rev/mins) in the emulsifying pot; While stirring B is added in the emulsifying pot; The speed that adds is as the criterion (promptly join the B phase raw material of A in mutually and all added remaining B phase raw material after the emulsifying again) with the whole emulsifyings of B phase raw material in the emulsifying pot, and evacuation when B phase raw material all adds after (vacuum is-0.1 atmospheric pressure), stirring homogenizing 3～5 minutes (stir speed (S.S.) is 50～100 rev/mins) are heated to 75～85 ℃ of insulations; Begin cooling after 10～30 minutes; When temperature drops to 45～55 ℃, add C phase raw material, stir and continue cooling, when temperature during at 35 ℃～40 ℃ homogenizing discharging in 1～2 minute get final product.
The preparation that method for preparing obtains is a facial cream.Different according to the use approach, the present composition is processed external preparation, like external facial cream, cosmetic water, cleansing milk, spray, essence or facial film.But be not limited to above-mentioned dosage form, can be according to known method in the skin care item industrial circle, aforementioned pharmaceutical compositions is processed various external preparation after by the known method degerming.
Preparation of the present invention, its usage and consumption are following:
Method: after clean of every day, on skin, smear preparation of the present invention, each is once sooner or later.
Consumption: confirm according to individual demand, smear preparation of the present invention in right amount and get final product.For the position that is prone to wrinkle, locate can smear repeatedly like canthus etc., be as the criterion with whole coverings.
Beneficial effect of the present invention:
Raw material selection of the present invention is the natural composition of releiving, and is little to skin irritation, gos deep into the skin basal layer through number of ways, recovers skin vitality, knows free radical, fundamentally plays the effect of crease-resistant wrinkle removal.Experiment proof preparation wrinkle removal effect of the present invention is remarkable, uses the texture that can obviously improve skin after 30 days, makes texture fine and smooth, can increase the glossiness of skin simultaneously, makes skin fine and smooth mellow and full pale.Raw material of the present invention obtains simply, method for preparing is convenient, is easy to accepted by consumers in general, has good application prospects and market prospect.
Foregoing invention content part of the present invention has been done detailed description to technical scheme of the present invention, and those skilled in the art get final product repetition the present invention and obtain technique effect of the present invention according to foregoing.Through the specific embodiment technology contents of the present invention being done further explanation below, understand content of the present invention so that those skilled in the art are clearer, is not limitation of the present invention, anyly is equal to replacement or known change all belongs to protection domain of the present invention.
Description of drawings
Describe the specific embodiment of the present invention in detail below in conjunction with accompanying drawing:
Fig. 1 is that Chinese medicine extraction liquid of the present invention is to DPPH measured by esr technique figure;
Fig. 2 is that Chinese medicine extraction liquid of the present invention is to ultra-oxygen anion free radical scavenging action figure;
Fig. 3 is that Chinese medicine extract of the present invention is to hydroxyl radical free radical scavenging action figure.
The specific embodiment
The used medical material of present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.Other raw material sources are seen table 1.
Table 1
Used emulsifying agent, stabilizing agent, stimulation inhibitory factor, antipruritic and antipruritic agent, antiseptic and the essence of preferred embodiment of the present invention is as above shown said; The antiseptic that can be applicable to cosmetics and the essence of other manufacturer production also can be used for the present invention; As long as meet institute of the present invention restricted portion; Can not influence the effect of skin care item of the present invention, therefore not do concrete qualification at this.Kieselguhr is available from chemical reagents corporation of traditional Chinese medicines group, specification: chemical pure 91053-39.
The used emulsifying equipment of the present invention is that (Beijing and not electromechanical research institute) produces, and it has functions such as homogenizing, stirring and temperature control.The emulsifying equipment that is used for the cosmetics preparation of other manufacturer production also can be used for the present invention, as long as operate in strict accordance with technological parameter of the present invention, all can reach effect according to the invention.
The preparation of embodiment 1 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Astragali 17g, Radix Ophiopogonis 13g, Radix Pseudostellariae 15g, Radix Salviae Miltiorrhizae 10g, Radix Glycyrrhizae 5g.
(2) crude drug mix is added deionized water, boil from liquid and constantly pick up counting, boiled 45 minutes; Said crude drug is 1: 10 with the mass and size g/ml ratio of deionized water, promptly adds the 600ml deionized water;
(3) stop heating, be cooled to 30 ℃, 200 orders filter;
(4) filtrating that obtains of step (3) is again through the kieselguhr vacuum filtration, and fineness is 500 orders, and vacuum is 0.05～0.1MPa, and vacuum has unsteady according to the variation of fluid flow, as long as in this scope, finally prepare Chinese medicine extract.
Measure pH value, solid content, electrical conductivity, measure the result and be: pH value is 5.0～6.5, solid content be 10～13% and electrical conductivity be 700～1200 μ s/cm
2
The preparation of embodiment 2 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Astragali 10g, Radix Ophiopogonis 30g, Radix Pseudostellariae 10g, Radix Salviae Miltiorrhizae 20g, Radix Glycyrrhizae 10g.
(2) crude drug mix is added deionized water, boil from liquid and constantly pick up counting, boiled 30 minutes; The mass volume ratio g/ml of said crude drug and deionized water is 1: 20, promptly adds the 1600ml deionized water;
(3) stop heating, be cooled to 45 ℃, 100 orders filter;
(4) filtrating that obtains of step (3) is again through the kieselguhr vacuum filtration, and fineness is 600 orders, and vacuum is 0.05～0.1MPa, and vacuum has unsteady according to the variation of fluid flow, as long as in this scope, finally prepare Chinese medicine extract.
Measure pH value, solid content, electrical conductivity, measure the result and be: pH value is 5.0～6.5, solid content be 10～13% and electrical conductivity be 700～1000 μ s/cm
2
The preparation of embodiment 3 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Astragali 20g, Radix Ophiopogonis 10g, Radix Pseudostellariae 25g, Radix Salviae Miltiorrhizae 15g, Radix Glycyrrhizae 20g.
(2) crude drug mix is added deionized water, boil from liquid and constantly pick up counting, boiled 90 minutes; The mass volume ratio of said crude drug and deionized water is 0.5: 10, promptly adds the 1800ml deionized water;
(3) stop heating, be cooled to 50 ℃, 200 orders filter;
(4) filtrating that obtains of step (3) is again through the kieselguhr vacuum filtration, and fineness is 700 orders, and vacuum is 0.05～0.1MPa, and vacuum has unsteady according to the variation of fluid flow, as long as in this scope, finally prepare Chinese medicine extract.
Measure pH value, solid content, electrical conductivity, measure the result and be: pH value is 5.0～6.5, solid content be 10～13% and electrical conductivity be 900～1200 μ s/cm
2
Afterwards can 95 ℃ insulation 30 minutes, sterilization; Water-bath is cooled to room temperature, adds the 0.6%LGP liquid preservative, obtains product.
The preparation of embodiment 4 sprays of the present invention
(1) with the Chinese medicine extract of embodiment 1 preparation vacuum 1.33Kpa (being 10mmHg), under 40～50 ℃ of environment, be condensed into relative density and be 1.2～1.3 extractum;
(2) 70% ethanol is slowly added in the above-mentioned extractum, leave standstill after 18 hours and get supernatant, filter rear filtrate and put the room temperature cooling, after the precipitate with ethanol cooling for the second time, add an amount of distilled water, move to the icebox cooling, after the filtration, it is subsequent use to be prepared into clear paste liquid;
(3) an amount of laurocapram solution (transdermal enhancer) is added in the clear paste liquid, be stirred to and be uniformly dispersed, divide in the spray bottle of packing into.
The preparation of the crease-resistant emulsion of embodiment 5 wrinkle removal of the present invention
1, raw material and consumption:
A phase: cetearyl alcohol 1wt%
Behenyl alcohol 0.5wt%
The two stearate 0.5wt% of tetramethylolmethane
Glyceryl monostearate 0.5wt%
Squalane 5wt%
Shea butter 3wt%
Dimethicone 3wt%
Water solublity Jojoba oil 4wt%
Vitamin E 1wt%
Bisabolol 0.2wt%
B phase: cetearyl glucoside (emulsifying agent) 1.2wt%
HANSHENGJIAO (stabilizing agent) 0.1wt%
Carbomer (stabilizing agent) 0.2wt%
Amino acid humectant 2wt%
Disodium EDTA (chelating agen) 0.05wt%
Hydrolysis avenin 8wt%
Stimulation inhibitory factor 2wt%
Antipruritic and antipruritic agent 2wt%
Phyto-hyaluronic acid 3wt%
Glycerol 5wt%
Butanediol 3wt%
C phase: antiseptic 0.4wt%
Essence 0.1wt%
Collagen protein 1wt%
10％NaOH 0.35wt％
Surplus is a deionized water.
2, method for preparing:
(1) takes by weighing each raw material by above-mentioned component and consumption;
(2) A being heated to 80 ℃ of stirrings respectively with B mutually mutually makes material dissolution complete;
(3) A is added in the emulsifying pot stirs, stir speed (S.S.) is 100 rev/mins, while stirring B is added in the emulsifying pot; The speed that adds is as the criterion with the whole emulsifyings of B phase raw material in the emulsifying pot; Evacuation after B phase raw material all adds (vacuum is-0.1 atmospheric pressure), stirring homogenizing 3 minutes, stir speed (S.S.) is 100 rev/mins, is heated to 75 ℃ of insulations; Begin cooling after 10 minutes; When temperature drops to 45 ℃, add C phase raw material, stir and continue cooling, when temperature during at 40 ℃ homogenizing discharging in 1～2 minute get final product.
The preparation of the crease-resistant emulsion of embodiment 6 wrinkle removal of the present invention
1, raw material and consumption:
A phase: cetearyl alcohol 2wt%
Behenyl alcohol 1.5wt%
The two stearate 1wt% of tetramethylolmethane
Glyceryl monostearate 1wt%
Squalane 3wt%
Shea butter 8wt%
Dimethicone 5wt%
Water solublity Jojoba oil 5wt%
Vitamin E 2wt%
Bisabolol 0.1wt%
B phase: cetearyl glucoside (emulsifying agent) 1wt%
HANSHENGJIAO (stabilizing agent) 0.2wt%
Carbomer (stabilizing agent) 0.2wt%
Amino acid humectant 4wt%
Disodium EDTA (chelating agen) 0.1wt%
Hydrolysis avenin 5wt%
Stimulation inhibitory factor 5wt%
Antipruritic and antipruritic agent 1wt%
Phyto-hyaluronic acid 5wt%
Glycerol 3wt%
Butanediol 5wt%
C phase: antiseptic 0.1wt%
Essence 0.2wt%
Collagen protein 1.5wt%
10％NaOH 0.2wt％
Surplus is a distilled water.
2, method for preparing:
(1) takes by weighing each raw material by above-mentioned component and consumption;
(2) A being heated to 85 ℃ of stirrings respectively with B mutually mutually makes material dissolution complete;
(3) A is added in the emulsifying pot stirs, stir speed (S.S.) is 50 rev/mins, while stirring B is added in the emulsifying pot; The speed that adds is as the criterion with the whole emulsifyings of B phase raw material in the emulsifying pot; Evacuation after B phase raw material all adds (vacuum is-0.1 atmospheric pressure), stirring homogenizing 5 minutes, stir speed (S.S.) is 50 rev/mins, is heated to 85 ℃ of insulations; Begin cooling after 30 minutes; When temperature drops to 55 ℃, add C phase raw material, stir and continue cooling, when temperature during at 35 ℃ homogenizing discharging in 1～2 minute get final product.
The preparation of the crease-resistant emulsion of embodiment 7 wrinkle removal of the present invention
1, raw material and consumption:
A phase: cetearyl alcohol 5wt%
Behenyl alcohol 2wt%
The two stearate 2wt% of tetramethylolmethane
Glyceryl monostearate 2wt%
Squalane 8wt%
Shea butter 5wt%
Dimethicone 3wt%
Water solublity Jojoba oil 3wt%
Vitamin E 3wt%
Bisabolol 0.5wt%
B phase: cetearyl glucoside (emulsifying agent) 3wt%
HANSHENGJIAO 0.05wt%
Carbomer 0.1wt%
Amino acid humectant 1wt%
Disodium EDTA (chelating agen) 0.15wt%
Hydrolysis avenin 10wt%
Stimulation inhibitory factor 1wt%
Antipruritic and antipruritic agent 3wt%
Phyto-hyaluronic acid 6wt%
Glycerol 4wt%
Butanediol 2wt%
C phase: antiseptic 0.5wt%
Essence 0.2wt%
Collagen protein 3wt%
10％NaOH 0.5wt％
Surplus is a pure water.
2, method for preparing:
(1) takes by weighing each raw material by above-mentioned component and consumption;
(2) A being heated to 80-85 ℃ of stirring respectively with B mutually mutually makes material dissolution complete;
(3) A is added in the emulsifying pot stirs, stir speed (S.S.) is 80 rev/mins), while stirring B is added in the emulsifying pot; The speed that adds is as the criterion with the whole emulsifyings of B phase raw material in the emulsifying pot; Evacuation after B phase raw material all adds (vacuum is-0.1 atmospheric pressure), stirring homogenizing 4 minutes, stir speed (S.S.) is 80 rev/mins, is heated to 80 ℃ of insulations; Begin cooling after 20 minutes; When temperature drops to 30 ℃, add C phase raw material, stir and continue cooling, when temperature during at 40 ℃ homogenizing discharging in 1～2 minute get final product.
The Chinese medicine extract efficacy test
1, remove DPPH free radical ability and measure, the extract of selecting embodiment 1 preparation for use is as sample, and this test method is carried out with reference to the method that following document provides:
Wang Chen, Zhang Jinmu. Study on Antioxidant Activity of Extracts of Celery Leaf [J]. Anhui agricultural sciences, 2006,34 (13): 3174-3175,3177.
LARRAURI?J?A，SNCHEZMORENO?C，SAURACALLIXTO.Effect?of?temperature?on?the?free?radical?scavenging?capacity?of?extracts?from?red?and?white?grape?peels[J].Agric?Food?Chem，1998，46：2694。
DPPH be a kind of very stable be the free radical at center with nitrogen, if extract can remove it, then point out extract to have valid density that reduces hydroxy radical, alkane free radical or oxyradical and the effect (Wang Chen etc., 2006) that interrupts the lipid peroxidation chain reaction.DPPH is highly stable in organic solvent, is purple, and a characteristic absorption peak is arranged at the 517nm place, and when it ran into free radical scavenger, the lone electron of DPPH was matched, and its color is shoaled, and diminishes at the absorbance of maximum absorption wave strong point.Therefore, can estimate removing effect through the variation of measuring absorbance to DPPH.
According to Larrauri (1998) method, accurately take by weighing 20mgDPPH, in the 250ml volumetric flask, obtaining concentration is the DPPH solution of 20mmol/L, the extract sample is become the test fluid of variable concentrations respectively with distilled water diluting with the dehydrated alcohol standardize solution.Get the 20mmol/L DPPH mixing afterreaction 30min of 2ml test fluid and 2ml, measure the variation of absorbance under the wavelength 517nm, control solvent replaces with dehydrated alcohol, is calculated as follows the suppression ratio of antioxidant.
Suppression ratio (%)=[1-(Ai-Aj)/Ac] * 100
In the formula, Ai is the absorbance of 2mlDPPH liquid and 2ml extracting solution; Aj is the absorbance of 2ml extracting solution and 2ml dehydrated alcohol; Ac is the absorbance of 2mlDPPH liquid and 2ml dehydrated alcohol.
Remove the result of the test of DPPH free radical ability mensuration and see Fig. 1; As can be seen from Figure 1, the concentration of extract is big more, and is strong more to the removing ability of DPPH free radical; Good removing effect is just arranged when extract concentration reaches 3%, and this shows that extracting solution has the ability of good removing DPPH.
2, remove the superoxide anion ability and measure, the extract of selecting embodiment 2 preparations for use is as sample.
This test method is carried out according to the method that following document provides: model is known, Yan Xiaojun, and Fang Guoming, etc. HMW Brown algae polyphenol antioxidant properties research [J]. aquatile journal, 1999,23 (5): 494-499.
Get the Tris-HCl buffer 4.5ml of 0.05mol/L pH8.2, place 25 ℃ of water-bath preheating 20min, add the sample and the 0.4ml of 1ml variable concentrations respectively; The pyrogallol solution of 25mmol/L; In 25 ℃ of water-baths, react 5min behind the mixing, add 8mol/L HCl 1.0ml cessation reaction, make reference with the Tris-HCl buffer; Measure absorbance at the 299nm place, calculate clearance rate.The blank group replaces sample with 1ml sample solvent, and each is handled and all does three repetitions.
The computing formula of clearance rate: ultra-oxygen anion free radical clearance rate (%)=100 (A1-A2)/A1, wherein A1 is barren mean light absorbency, A2 is the mean light absorbency of sample.
Extracting solution to ultra-oxygen anion free radical scavenging action see Fig. 2, as can be seen from Figure 2, extract concentration is big more, and is strong more to the removing ability of superoxide anion.100% stock solution can keep 92.56% clearance rate, proves that Chinese medicine extract provided by the invention has the ability of stronger removing ultra-oxygen anion free radical, can be used for preparing cosmetics, especially is used for preparing the cosmetics with anti-ageing effect.
3, to the mensuration (salicylic acid method) of Hydroxyl Radical Scavenging, the extract of selecting embodiment 3 preparations for use is as sample.
This test method is carried out according to the method that following document provides: Ding Lijun, all ditch between fields brightness, Lin Yanru. the extraction of flavonoid substance and Study on antioxidation thereof [J] in the Dicranopteris dichotoma. and Food Science, 2005,26 (8): 77-83.
Hydroxyl radical free radical is produced by the Fenton reaction, and OH oxidation salicylic acid produces has 2 of characteristic absorption to 510nm light, and the 3-resorcylic acid is caught the clearance rate that the resulting product of OH is confirmed OH through measuring salicylic acid.Hydroxyl radical free radical is the most active free radical of chemical property in the active oxygen, and it almost can react with any biomacromolecule in the living cells, and response speed is exceedingly fast, and is to the maximum free radical of body harm.Catch the clearance rate that the resulting product of OH is confirmed OH through measuring salicylic acid, can reduce this light absorption value if add material in the reaction system with removing OH effect.Therefore can the amount of hydroxyl and the ability that test substance is removed hydroxyl radical free radical be described through its content of spectrophotometry.
2mmol/L FeSO in the 25ml color comparison tube
43ml, 1mmol/L H
2O
23ml shakes up, and then adds 6mmol/L salicylic acid 3ml, shakes up, and behind 37 ℃ of heating in water bath 15min, takes out, and surveys its absorbance A 0.Add certain density liquid 0.2ml to be measured, 0.4ml, 0.6ml, 0.8ml, 1.0ml then respectively, and then add distilled water 0.8ml, 0.6ml, 0.4ml, 0.2ml, 0ml respectively, shake up, continue heating in water bath 15min, take out and survey its absorbance A x.The reduction of the system absorbance that is caused for common 1.0ml liquid and the distilled water to be measured that adds after eliminating, method is the same, surveys its absorbance A00 behind the constant temperature 15min, adds the 1ml distilled water, survey its absorbance A xx once again after shaking up, A reduction=A00-Axx.
Liquid to be measured to the OH clearance rate is: OH clearance rate (%)=100 (A0-Ax-A reduction)/A0
Mensuration result to Hydroxyl Radical Scavenging sees Fig. 3, and as can be seen from Figure 3, extract concentration is big more, and is strong more to the removing ability of hydroxy radical.Proof the present invention has good effect to knowing free radical, and wrinkle removal is crease-resistant effectively.
Clinical experiment of the present invention and result
Experimental technique: select age bracket at 25 years old to 55 years old volunteer, 50 of male volunteers, 50 of women volunteers.Cardinal symptom: face has microgroove, some position wrinkle is obvious, the colour of skin is obscure.Volunteer is divided into two groups at random, every group 50 people.
Test group: after clean of every day, the whitening emulsion that on facial skin, applies the embodiment of the invention 5 preparations is an amount of, and each is once sooner or later.Matched group: after clean of every day, it is an amount of on facial skin, to apply commercially available wrinkle removal emulsion, and each is once sooner or later.3 days, 7 days, 1 month, 3 months each statistics once.
Evaluation criterion:, do skin texture experiment and naked eyes visual experiment through patient's readme impression.Effectively: the skin texture degree obviously attenuates greasy, and perusal face microgroove obviously reduces, and dark stricture of vagina shoals.Invalid: skin texture and the preceding no any variation of experiment.
Result on trial: this product had the wrinkle removal wrinkle removal effect that obviously is superior to the commercially available prod in 3 days, and effective percentage is higher than 80%, and the commercially available prod is merely 50%.Use that effective percentage reaches 100% after 30 days, the commercially available prod effective percentage is 80%.And can obviously increase the glossiness of skin, the skin exquisiteness is mellow and full, also has certain whitening effect.There is not an example reaction phenomenons such as allergy, skin discomfort to occur.
Claims (9)
1. the skin care compositions with the crease-resistant effect of wrinkle removal is characterized in that, said compositions comprise A mutually with B mutually, said A comprises oils and fats mutually; Said B comprises Chinese medicine extract mutually, and said Chinese medicine extract is processed by following weight parts proportion raw material medicine:
10～20 parts of the Radixs Astragali, 10～30 parts of Radix Ophiopogonis, 10～25 parts of Radix Pseudostellariaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 5～20 parts in Radix Glycyrrhizae.
2. skin care compositions according to claim 1 is characterized in that, said B also comprises one or more in emulsifying agent, amino acid humectant, chelating agen, avenin and the phyto-hyaluronic acid mutually.
3. skin care compositions according to claim 2 is characterized in that, said emulsifying agent is the cetearyl glucoside; Said chelating agen is a disodium EDTA.
4. skin care compositions according to claim 3 is characterized in that, B also comprises one or more in glycerol, butanediol, stabilizing agent, stimulation inhibitory factor and the antipruritic and antipruritic agent mutually in the said compositions.
5. skin care compositions according to claim 4; It is characterized in that said oils and fats comprises one or more in cetearyl alcohol, behenyl alcohol, the two stearates of tetramethylolmethane, glyceryl monostearate, squalane, shea butter, dimethicone, water solublity Jojoba oil, vitamin E and the bisabolol.
6. skin care compositions according to claim 5 is characterized in that said compositions also comprises the C phase, and said C comprises one or more in antiseptic, collagen protein, essence and the sodium hydroxide mutually.
7. skin care compositions according to claim 6 is characterized in that, said each amounts of components is: the A phase: cetearyl alcohol 1～5wt%
Behenyl alcohol 0.5～2wt%
The two stearate 0.5～2wt% of tetramethylolmethane
Glyceryl monostearate 0.5～2wt%
Squalane 3～8wt%
Shea butter 3～8wt%
Dimethicone 3～5wt%
Water solublity Jojoba oil 3～5wt%
Vitamin E 1～3wt%
Bisabolol 0.1～0.5wt%
B phase: emulsifying agent 1～3wt%
Stabilizing agent 0.1～0.4wt%
Amino acid humectant 1～4wt%
Chelating agen 0.05～0.15wt%
Avenin 5～10wt%
Stimulation inhibitory factor 1～5wt%
Antipruritic and antipruritic agent 1～3wt%
Phyto-hyaluronic acid 3～6wt%
Glycerol 3～5wt%
Butanediol 3～5wt%
Chinese medicine extract 1～5wt%
C phase: antiseptic 0.1～0.5wt%
Essence 0.1～0.3wt%
Collagen protein 1～3wt%
Sodium hydroxide 0.2～0.5wt%
Surplus is a water.
8. skin care compositions according to claim 7 is characterized in that said Chinese medicine extract is processed according to following method, and concrete steps are:
(1) takes by weighing each crude drug according to said component of claim 7 and consumption;
(2) crude drug is mixed add entry, boil from liquid and constantly pick up counting, boiled 30～180 minutes; The mass volume ratio g/ml of said crude drug and water is 0.5～1: 10～20;
(3) stop heating, be cooled to 30～50 ℃, 100～200 orders filter;
(4) filtrating that obtains of step (3) through 500～700 order vacuum filtrations, vacuum is 0.05～0.1MPa, promptly prepares Chinese medicine extract again.
9. a method for preparing the said skin care compositions of claim 8 is characterized in that, said method step is following:
(1) prepares each raw material by the said compositions of claim 8;
(2) A being heated to 80～85 ℃ of stirrings respectively with B mutually mutually makes material dissolution complete;
(3) A is added in the emulsifying pot stirs; While stirring B is added in the emulsifying pot, the speed of adding is as the criterion with the whole emulsifyings of B phase raw material in the emulsifying pot, and evacuation, stirring homogenizing are 3～5 minutes after B phase raw material all adds; Be heated to 75～85 ℃ of insulations and begin cooling after 10～30 minutes; When temperature drops to 45～55 ℃, add C phase raw material, stir and continue cooling, when temperature during at 35 ℃～40 ℃ homogenizing discharging in 1～2 minute get final product.
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| CN104382793A (en) * | 2014-11-27 | 2015-03-04 | 固镇县人民医院 | Chinese herbal medicinal ingredient cleansing milk |
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| CN102836093B (en) * | 2012-09-26 | 2013-06-12 | 关节动力安达（天津）生物科技有限公司 | Facial cream containing type I collagen |
| CN104352383A (en) * | 2014-10-20 | 2015-02-18 | 东莞市阿比亚能源科技有限公司 | Facial cleanser |
| CN104352382A (en) * | 2014-10-20 | 2015-02-18 | 东莞市阿比亚能源科技有限公司 | Essence |
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| CN105853292B (en) * | 2016-05-13 | 2019-03-19 | 广州肽斗生物科技有限公司 | A kind of Essence, preparation method and application |
| CN111973471A (en) * | 2019-05-24 | 2020-11-24 | 西安博鸿生物技术有限公司 | Cosmetic composition |
| CN110141542B (en) * | 2019-06-27 | 2022-05-17 | 福建师范大学 | Allergy-relieving agent containing radix pseudostellariae and preparation method thereof |
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| CN101843572A (en) * | 2010-06-11 | 2010-09-29 | 成佩秀 | Skin-care anti-wrinkle face mask |
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