CN104739726A - Traditional Chinese medicine toothpaste and preparation method thereof - Google Patents
Traditional Chinese medicine toothpaste and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine toothpaste which contains a hydroxypropyl-beta-cyclodextrin inclusion compound, wherein the hydroxypropyl-beta-cyclodextrin inclusion compound contains a traditional Chinese medicine extract and hydroxypropyl-beta-cyclodextrin; the mass ratio of the traditional Chinese medicine extract to hydroxypropyl-beta-cyclodextrin is 1:(3-7); and the traditional Chinese medicine extract comprises the following components in percentage by mass: 15-35 percent of a coptis chinensis extract, 20-40 percent of a cortex phellodendri extract, 15-35 percent of a radix scutellariae extract and 10-30 percent of a pseudo-ginseng extract. According to the traditional Chinese medicine toothpaste, the concentration of the traditional Chinese medicine extract is high enough so that the traditional Chinese medicine toothpaste has the efficacy of clearing away heat, reducing internal heat and treating oral gingival inflammation, gingival bleeding and oral ulcer, and has favorable smell and taste and high stability.
Description
Technical field
The present invention relates to a kind of toothpaste and preparation method thereof, especially a kind of Chinese medicine toothpaste containing Chinese medicine extract and preparation method thereof.
Background technology
The making of Chinese medicinal toothpaste is generally divided into two steps, and first is extraction and the post-production process of Chinese medicine ingredients; Second is be added in basicly stable formulation of tooth-paste by active component.
Traditional Traditional Chinese medicine extraction method has infusion process, percolation, decocting method, reflux extraction and continuous circumfluence extraction method etc., is summarized as follows respectively:
A) infusion process: herbal powder or fragment are loaded in suitable container during infusion process, adds suitable solvent (as ethanol, rare alcohol or water), and dipping medical material is with the method for stripping wherein composition.This law is relatively simple, but leaching rate is poor, and as being solvent with water, its extracting solution is easy to moldy metamorphism, notably adds suitable antiseptic.
B) percolation: percolation is contained in percolator by herbal powder, constantly adds novel solvent, make it penetrate medical material, flows out a kind of leaching method of leachate from top to bottom from percolator bottom.When solvent infilters the increasing of medicated powder dissolved element proportion and moves down, its position is just replaced in the solution on upper strata or rare immersion, causes good concentration difference, and diffusion energy is carried out preferably, therefore leaching effect is better than infusion process.But answer coutroi velocity, on powder, supplement novel solvent at any time oozing in transient, make till effective ingredient fully leaches in medical material, maybe when ooze dropping liquid color extremely shallow or ooze the volume gushing liquid be equivalent to crude drug heavy 10 times time, just can think and substantially extract completely.Often the solvent of rare sepage of collecting as another batch of new raw material is used in a large amount of production.
C) decocting method: decocting method is traditional leaching method that China uses the earliest, and container used is generally pottery, sand tank or copper, enamel ware, should not use iron pan, in order to avoid medicinal liquid variable color.Preferably often stir during straight fire heating, in order to avoid local medical material is heated too high, be easily charred.
D) reflux extraction: application organic solvent heating extraction, need adopt reflux device, in order to avoid solvent volatilization loss.When operating in a small amount, can connect reflux condenser on round-bottomed flask, the in-built medical material of bottle is about 30 ~ 50% of capacity, the dipped medical material surface about 1 ~ 2cm of solvent.Reflux in a water bath, general maintenance, seethes with excitement about 1 hour.Let cool filtration, then in medicinal residues solubilizer, do second and third reflux about half an hour respectively, or to substantially carrying most effective ingredient.Comparatively cold-maceration is high for this method extraction efficiency, adopts continuous extraction in a large amount of production more.
E) continuous circumfluence extraction method: application volatile organic solvent extracts Chinese herbal medicine effective ingredients, no matter small test or large-scale production, all with continuous extraction as well, and need be less by quantity of solvent, extract component is also more complete.Laboratory is commonly used extraction equipment for fat or is claimed apparatus,Soxhlet's.Continuous extraction, generally needs a few hours could extract completely.Extract component heated time is longer, and the labile composition of case of thermal instability should not adopt this method.
After having prepared extract, most of ways have on the market been direct or have been added in formulation of tooth-paste by extract after suitably processing (as spraying dry is processed into powder, is condensed into extractum, uses suitable solvent dissolving etc.) and use at present.
The development process of current commercially available Chinese medicinal toothpaste has been set forth above from two aspects, can find out that the extraction of active ingredient of Chinese herbs and the addition manner of extract all exist certain limitation and shortcoming, the extract stability extract through long-time high-temperature heating as needed, recovery rate is on the low side, extracted is unstable and on the stability etc. affecting target product.
Traditional Traditional Chinese medicine extraction method (infusion process, percolation, decocting method, reflux extraction and continuous circumfluence extraction method etc.) exists that Extracting temperature is high, extraction efficiency is low, Extraction solvent is residual and the problem such as recovery rate is on the low side substantially; After obtaining corresponding extract, the abnormal smells from the patient great majority of extract have acid, hardship, the bad smell such as puckery; And due to more containing active component, add if want in formulation of tooth-paste the extract enough playing therapeutically effective amount and in most cases can cause lotion of toothpaste formula unstability, thus a effective product cannot be become, in order to formula for a product stability can be made and reduce bad smell, generally, can only by reducing the use of extract thus to meet formula basicly stable and make mastic substantially not have bad mouthfeel.
Summary of the invention
The object of the invention is to overcome above-mentioned the deficiencies in the prior art part and the Chinese medicine toothpaste that a kind of Chinese medicine extract containing enough playing therapeutically effective amount being provided, there is good stability, do not have bad smell and mouthfeel.
For achieving the above object, the technical scheme that the present invention takes is: a kind of Chinese medicine toothpaste, containing hydroxypropyl-beta-cyclodextrin inclusion in described toothpaste, described hydroxypropyl-beta-cyclodextrin inclusion contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:3 ~ 7;
Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 15 ~ 35%, Cortex Phellodendri extract 20 ~ 40%, Scutellaria baicalensis extract 15 ~ 35%, notoginseng extract 10 ~ 30%.
Chinese medicine toothpaste of the present invention, enclose is carried out by Chinese medicine extract being adopted HP-β-CD, mixed extract clathrate is obtained through enclose, due to the good aqueous solubility of HP-β-CD, clathrate is made to have good water solublity, increase the dissolubility of Chinese medicine extract in formulation of tooth-paste, make Chinese medicine extract can add enough concentration thus play corresponding efficient functional in formulation of tooth-paste; Meanwhile, have benefited from the enclose of HP-β-CD, effectively can cover Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, the strong hardship of Radix Notoginseng, the bad smell such as puckery, sweet, substantially improve the mouthfeel containing higher Chinese medicine extract toothpaste and abnormal smells from the patient; Meanwhile, because Chinese medicine extract is by HP-β-CD enclose, effectively intercepts the contact of Chinese medicine extract other compositions directly and in formulation of tooth-paste, added the stability of formulation of tooth-paste.
The applicant finds through large quantity research, in described hydroxypropyl-beta-cyclodextrin inclusion, when the mass ratio of Chinese medicine extract and HP-β-CD is 1:3 ~ 7, HP-β-CD can enclose Chinese medicine extract preferably, simultaneously by the Chinese medicine extract of enclose can preferably in formulation of tooth-paste stripping play corresponding efficient functional.Present inventor is based on Basic Theories of Chinese Medicine, find through large quantity research, described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 15 ~ 35%, Cortex Phellodendri extract 20 ~ 40%, Scutellaria baicalensis extract 15 ~ 35%, notoginseng extract 10 ~ 30% time, and adopting HP-β-CD enclose to become the form of clathrate to add in toothpaste described Chinese medicine extract, gained toothpaste can have effect of good heat clearing away and internal heat reducing, treatment dental gingival inflammation, gingival hemorrhage, oral ulcer.Meanwhile, present inventor also finds, when in described Chinese medicine extract, the content of Rhizoma Coptidis and Cortex Phellodendri extract larger and the two content more close to time, described toothpaste is better to the therapeutic effect of oral cavity gingivitis.
Chinese medicine toothpaste of the present invention, by Rhizoma Coptidis extract, Cortex Phellodendri extract, Scutellaria baicalensis extract and notoginseng extract HP-β-CD enclose, then hydroxypropyl-beta-cyclodextrin inclusion is joined in lotion of toothpaste substrate, support toothpaste is pharmaceutical carrier, by Chinese medicine ingredients dispersion in the oral cavity, by oral mucosa and Sublingual capillary absorbance, directly enter in body circulation, reach the object of prevention and therapy disease.Toothpaste containing described hydroxypropyl-beta-cyclodextrin inclusion, owing to wherein containing Rhizoma Coptidis extract, Cortex Phellodendri extract, Scutellaria baicalensis extract and notoginseng extract, there is effect of heat clearing away and internal heat reducing, treatment dental gingival inflammation, gingival hemorrhage and oral ulcer, wherein Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae three medicine share, play synergy, strengthen respective heat clearing away and internal heat reducing, effect of bacteriostat degerming, thus play disease such as treatment gingivitis, oral ulcer etc., be equipped with Radix Notoginseng again, play effect of hemostasis by removing blood stasis, thus can the diseases such as gingival hemorrhage be treated.
As the preferred implementation of Chinese medicine toothpaste of the present invention, described Rhizoma Coptidis extract adopts following methods to prepare: Rhizoma Coptidis was pulverized 60 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 55 DEG C, extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 0.5 ~ 2.5h, obtains Rhizoma Coptidis extract;
Described Cortex Phellodendri extract adopts following methods to prepare: Cortex Phellodendri was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 45 DEG C, and extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 0.5 ~ 2.5h, obtains Cortex Phellodendri extract;
Described Scutellaria baicalensis extract adopts following methods to prepare: Radix Scutellariae was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 50 DEG C, and extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 1.5 ~ 3.5h, obtains Scutellaria baicalensis extract;
Described notoginseng extract adopts following methods to prepare: Radix Notoginseng was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 50 DEG C, extracting pressure is 25 ~ 35mPa, entrainer made by 95% ethanol, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 1.5 ~ 3.5h, obtains notoginseng extract.
Present inventor uses supercritical fluid extraction method to extract Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae and Radix Notoginseng respectively, preferably extracting factor is obtained separately respectively through lot of experiments, at low temperature to room temperature, there is no dissolvent residual, extraction time completes extraction to above four kinds of extracts shorter, make Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae and Radix Notoginseng effective active thing be able to abundant preservation, and the active constituent content of the more traditional extraction of the effective ingredient contained in extract is higher.
As the preferred implementation of Chinese medicine toothpaste of the present invention, the mass ratio of described Chinese medicine extract and HP-β-CD is 1:5.Present inventor finds, when the mass ratio of described Chinese medicine extract and HP-β-CD is 1:5, lower to the requirement of enclose temperature and time in enclose process, namely more easily realizes enclose.
As the preferred implementation of Chinese medicine toothpaste of the present invention, described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 25%, Cortex Phellodendri extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%.Present inventor find, when described Chinese medicine extract contain described specific ratio combination form time, the combined therapy effect of gained toothpaste to oral cavity gingivitis, oral ulcer and gingival hemorrhage is best.
As the preferred implementation of Chinese medicine toothpaste of the present invention, described hydroxypropyl-beta-cyclodextrin inclusion adopts following methods to be prepared from:
(1) HP-β-CD is mixed with saturated aqueous solution;
(2) Rhizoma Coptidis extract, Cortex Phellodendri extract, Scutellaria baicalensis extract and notoginseng extract are mixed, obtain Chinese medicine extract;
(3) joined in the saturated aqueous solution of step (1) by the Chinese medicine extract that step (2) obtains and carry out enclose, enclose temperature is 35 ~ 55 DEG C, stirs 1 ~ 3 hour, dry after filtering, and obtains hydroxypropyl-beta-cyclodextrin inclusion.
In step described above (1), HP-β-CD is mixed with saturated aqueous solution, during operation, only needs in water, add excessive HP-β-CD, then filter and can obtain HP-β-CD saturated aqueous solution.
For improving the recovery rate of hydroxypropyl-beta-cyclodextrin inclusion, preferably, in described step (3), after enclose, first enclose solution is positioned over-8 DEG C to 4 DEG C cold preservations and places a night, the clathrate generated almost entirely is separated, and then filtration drying, obtain hydroxypropyl-beta-cyclodextrin inclusion.
Present inventor adopts HP-β-CD to carry out enclose to four kinds of Chinese medicine extract simultaneously, and study through lot of experiments, draw best clathrate process, the yield of clathrate can be improved, and four kinds of Chinese medicine extract add in formulation of tooth-paste after enclose again, can well play and increase the dissolubility of Chinese medicine extract in formulation of tooth-paste, four kinds of Chinese medicine extract are made to have enough concentration, thus play corresponding efficient functional, and hidden the bad smell of Chinese medicine extract and substantially improved mouthfeel and the abnormal smells from the patient of high extract toothpaste, and add the stability of formulation of tooth-paste.
As the preferred implementation of Chinese medicine toothpaste of the present invention, the enclose temperature in described step (3) is 45 DEG C, and mixing time is 2 hours.When described enclose temperature is 45 DEG C, and mixing time is 2 constantly little, and with this understanding, described Chinese medicine extract can better by HP-β-CD enclose.
As the preferred implementation of Chinese medicine toothpaste of the present invention, the weight content of described hydroxypropyl-beta-cyclodextrin inclusion in toothpaste is 0.1 ~ 10%.The hydroxypropyl-beta-cyclodextrin inclusion that weight content is 0.1 ~ 10% is added in toothpaste, under the prerequisite ensureing formulation of tooth-paste stability, the Chinese medicine extract in described formulation of tooth-paste can be made to contain enough concentration, thus playing corresponding curative effect, gained toothpaste has effect of good heat clearing away and internal heat reducing, treatment dental gingival inflammation, gingival hemorrhage, oral ulcer.
As the preferred implementation of Chinese medicine toothpaste of the present invention, described toothpaste is also containing wetting agent, binding agent, foaming agent, abrasivus, saccharin sodium, essence and deionized water, and the parts by weight of each component contained in every 100 parts of described toothpaste are: wetting agent 18 ~ 57 parts, binding agent 0.8 ~ 4 part, foaming agent 1.5 ~ 5.5 parts, abrasivus 12 ~ 60 parts, saccharin sodium 0.1 ~ 0.3 part, hydroxypropyl-beta-cyclodextrin inclusion 0.1 ~ 10 part, 0.8 ~ 2 part, essence, surplus are deionized water.
As the more preferably embodiment of Chinese medicine toothpaste of the present invention, the parts by weight of each component contained in every 100 parts of described toothpaste are: wetting agent 30 ~ 40 parts, binding agent 0.8 ~ 2 part, foaming agent 2 ~ 5 parts, abrasivus 26 ~ 35 parts, saccharin sodium 0.2 part, hydroxypropyl-beta-cyclodextrin inclusion 0.8 ~ 5 part, 1 ~ 1.5 part, essence, surplus are deionized water.When Chinese medicine toothpaste of the present invention contains the composition of content described above, described Chinese medicine toothpaste has effect of good heat clearing away and internal heat reducing, treatment dental gingival inflammation, gingival hemorrhage and oral ulcer.
As the most preferred embodiment of Chinese medicine toothpaste of the present invention, the parts by weight of each component contained in every 100 parts of described toothpaste are: wetting agent 38 parts, binding agent 1 part, foaming agent 2.5 parts, abrasivus 28 parts, saccharin sodium 0.2 part, hydroxypropyl-beta-cyclodextrin inclusion 1.2 parts, 1.2 parts, essence, surplus are deionized water.When the composition that Chinese medicine toothpaste of the present invention contains content described above combines, described Chinese medicine toothpaste has effect of best heat clearing away and internal heat reducing, treatment dental gingival inflammation, gingival hemorrhage and oral ulcer.
As the preferred implementation of Chinese medicine toothpaste of the present invention, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
As the preferred implementation of Chinese medicine toothpaste of the present invention, described toothpaste is adopted and is prepared from the following method:
(1) wetting agent, binding agent, foaming agent, abrasivus, saccharin sodium and deionized water are mixed, keep vacuum at-0.09Mpa ~-0.096Mpa, stir;
(2) add essence and hydroxypropyl-beta-cyclodextrin inclusion, keep vacuum at-0.09Mpa ~-0.096Mpa, stir, obtain Chinese medicine toothpaste.
In the preparation process of toothpaste described above, the concrete formula of step (1) visual toothpaste and select suitable mixing time, such as 20 ~ 50 minutes; Described step (2) also can select suitable mixing time, such as 10 ~ 50 minutes according to the concrete formula of toothpaste.Toothpaste of the present invention adopts a step cream method to be prepared from, and gained mastic has good stability.
Chinese medicine toothpaste of the present invention, Chinese medicine extract uses suitable HP-β-CD inclusion technique, increase Rhizoma Coptidis extract, Cortex Phellodendri extract, Scutellaria baicalensis extract and the notoginseng extract dissolubility in formulation of tooth-paste, make four kinds of Chinese medicine extract in toothpaste, have enough concentration thus play corresponding effect.And four kinds of Chinese medicine extract are after the enclose of HP-β-CD, the bad smells such as the hardship of Rhizoma Coptidis extract, Cortex Phellodendri extract, the bitterness of Scutellaria baicalensis extract and notoginseng extract is sweet are fully hidden, substantially improve the mouthfeel of the toothpaste of high-load Chinese medicine extract, simultaneously, after HP-β-CD enclose, enhance the stability of the formulation of tooth-paste containing high-load Rhizoma Coptidis extract, Cortex Phellodendri extract, Scutellaria baicalensis extract and notoginseng extract.
Detailed description of the invention
For better the object, technical solutions and advantages of the present invention being described, below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:3; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 20%, Cortex Phellodendri extract 40%, Scutellaria baicalensis extract 20%, notoginseng extract 20%.
In hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment, described Rhizoma Coptidis extract adopts following methods to prepare: Rhizoma Coptidis was pulverized 60 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 55 DEG C, extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 0.5 ~ 2.5h, obtains Rhizoma Coptidis extract;
Described Cortex Phellodendri extract adopts following methods to prepare: Cortex Phellodendri was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 45 DEG C, and extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 0.5 ~ 2.5h, obtains Cortex Phellodendri extract;
Described Scutellaria baicalensis extract adopts following methods to prepare: Radix Scutellariae was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 50 DEG C, and extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 1.5 ~ 3.5h, obtains Scutellaria baicalensis extract;
Described notoginseng extract adopts following methods to prepare: Radix Notoginseng was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 50 DEG C, extracting pressure is 25 ~ 35mPa, entrainer made by 95% ethanol, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 1.5 ~ 3.5h, obtains notoginseng extract.
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment adopts following methods to be prepared from:
(1) HP-β-CD is mixed with saturated aqueous solution: in water, add excessive HP-β-CD, then filters and can obtain HP-β-CD saturated aqueous solution;
(2) Rhizoma Coptidis extract, Cortex Phellodendri extract, Scutellaria baicalensis extract and notoginseng extract are mixed, obtain Chinese medicine extract;
(3) Chinese medicine extract that step (2) obtains is joined in the saturated aqueous solution of step (1) carry out enclose, enclose temperature is 35 ~ 55 DEG C, stir 1 ~ 3 hour, enclose solution is positioned over-8 DEG C to 4 DEG C cold preservations and places a night, the clathrate generated almost entirely is separated, then filtration drying, obtains hydroxypropyl-beta-cyclodextrin inclusion.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
Chinese medicine toothpaste described in the present embodiment adopts following methods to be prepared from:
(1) wetting agent, binding agent, foaming agent, abrasivus, saccharin sodium and deionized water are mixed, keep vacuum at-0.09Mpa ~-0.096Mpa, stir 20 ~ 50 minutes;
(2) add essence and hydroxypropyl-beta-cyclodextrin inclusion, keep vacuum at-0.09Mpa ~-0.096Mpa, stir 10 ~ 50 minutes, obtain Chinese medicine toothpaste.
Embodiment 2
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:4; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 20%, Cortex Phellodendri extract 30%, Scutellaria baicalensis extract 30%, notoginseng extract 20%.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
In the present embodiment, the Rhizoma Coptidis extract in described hydroxypropyl-beta-cyclodextrin inclusion, Cortex Phellodendri extract, Scutellaria baicalensis extract are all identical with embodiment 1 with the preparation method of Chinese medicine toothpaste described in the preparation method of notoginseng extract, the preparation method of described hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment.
Embodiment 3
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:5; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 25%, Cortex Phellodendri extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
In the present embodiment, the Rhizoma Coptidis extract in described hydroxypropyl-beta-cyclodextrin inclusion, Cortex Phellodendri extract, Scutellaria baicalensis extract are all identical with embodiment 1 with the preparation method of Chinese medicine toothpaste described in the preparation method of notoginseng extract, the preparation method of described hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment.
Embodiment 4
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:6; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 30%, Cortex Phellodendri extract 25%, Scutellaria baicalensis extract 20%, notoginseng extract 25%.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
In the present embodiment, the Rhizoma Coptidis extract in described hydroxypropyl-beta-cyclodextrin inclusion, Cortex Phellodendri extract, Scutellaria baicalensis extract are all identical with embodiment 1 with the preparation method of Chinese medicine toothpaste described in the preparation method of notoginseng extract, the preparation method of described hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment.
Embodiment 5
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:5; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 25%, Cortex Phellodendri extract 35%, Scutellaria baicalensis extract 30%, notoginseng extract 10%.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
In the present embodiment, the Rhizoma Coptidis extract in described hydroxypropyl-beta-cyclodextrin inclusion, Cortex Phellodendri extract, Scutellaria baicalensis extract are all identical with embodiment 1 with the preparation method of Chinese medicine toothpaste described in the preparation method of notoginseng extract, the preparation method of described hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment.
Embodiment 6
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:7; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 35%, Cortex Phellodendri extract 20%, Scutellaria baicalensis extract 25%, notoginseng extract 20%.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
In the present embodiment, the Rhizoma Coptidis extract in described hydroxypropyl-beta-cyclodextrin inclusion, Cortex Phellodendri extract, Scutellaria baicalensis extract are all identical with embodiment 1 with the preparation method of Chinese medicine toothpaste described in the preparation method of notoginseng extract, the preparation method of described hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment.
Embodiment 7
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:3; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 15%, Cortex Phellodendri extract 40%, Scutellaria baicalensis extract 15%, notoginseng extract 30%.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
In the present embodiment, the Rhizoma Coptidis extract in described hydroxypropyl-beta-cyclodextrin inclusion, Cortex Phellodendri extract, Scutellaria baicalensis extract are all identical with embodiment 1 with the preparation method of Chinese medicine toothpaste described in the preparation method of notoginseng extract, the preparation method of described hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment.
Embodiment 8
A kind of embodiment of Chinese medicine toothpaste of the present invention, in Chinese medicine toothpaste described in the present embodiment, the component containing following weight portion in every 100 parts of described toothpaste:
Hydroxypropyl-beta-cyclodextrin inclusion described in the present embodiment contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:4; Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 35%, Cortex Phellodendri extract 15%, Scutellaria baicalensis extract 35%, notoginseng extract 15%.
In the present embodiment, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
In the present embodiment, the Rhizoma Coptidis extract in described hydroxypropyl-beta-cyclodextrin inclusion, Cortex Phellodendri extract, Scutellaria baicalensis extract are all identical with embodiment 1 with the preparation method of Chinese medicine toothpaste described in the preparation method of notoginseng extract, the preparation method of described hydroxypropyl-beta-cyclodextrin inclusion and the present embodiment.
Embodiment 9
Chinese medicine toothpaste stability test of the present invention
Adopt the Chinese medicine toothpaste taste subjects that embodiment 1 ~ 8 prepares, Chinese medicine toothpaste embodiment 1 ~ 8 prepared all is positioned in the baking oven of 50 DEG C, whether occurs fuel-displaced water outlet phenomenon, whether outward appearance has color change, whether toothpaste abnormal smells from the patient is consistent with temperature under room temperature every observation in 15 days toothpaste.Observe discovery in 3 months, all there is not fuel-displaced water outlet phenomenon in the Chinese medicine toothpaste that embodiment 1 ~ 8 prepares, appearance color does not change substantially, and toothpaste abnormal smells from the patient is also consistent with under room temperature.Illustrate that the Chinese medicine toothpaste that embodiment 1 ~ 8 prepares is at high temperature basically identical with properties under room temperature, totally all there is good stability.
Embodiment 10
In Chinese medicine toothpaste of the present invention, Chinese medicine extract ratio contained by hydroxypropyl-beta-cyclodextrin inclusion is on the impact of the therapeutic effect of oral cavity gingivitis, gingival hemorrhage and oral ulcer
Test is divided into matched group and experimental group, experimental group is set to 1 ~ 8 group, in the toothpaste that experimental group 1 ~ 8 adopts, the component all containing following weight portion in every 100 parts of toothpaste: wetting agent 18 ~ 57 parts, binding agent 0.8 ~ 4 part, foaming agent 1.5 ~ 5.5 parts, abrasivus 12 ~ 60 parts, saccharin sodium 0.1 ~ 0.3 part, hydroxypropyl-beta-cyclodextrin inclusion 0.1 ~ 10 part, 0.8 ~ 2 part, essence, surplus are deionized water; Described hydroxypropyl-beta-cyclodextrin inclusion contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:3 ~ 7.
In the toothpaste of experimental group 1 ~ 8 except the Chinese medicine extract difference contained in described hydroxypropyl-beta-cyclodextrin inclusion, the content of all the other components and each component is all identical.The constituent content of the Chinese medicine extract contained in hydroxypropyl-beta-cyclodextrin inclusion described in the toothpaste of experimental group 1 ~ 8 is as follows respectively:
Chinese medicine extract in experimental group 1 is made up of the component of following mass percentage: Rhizoma Coptidis extract 20%, Cortex Phellodendri extract 40%, Scutellaria baicalensis extract 20%, notoginseng extract 20%;
Chinese medicine extract in experimental group 2 is made up of the component of following mass percentage: Rhizoma Coptidis extract 20%, Cortex Phellodendri extract 30%, Scutellaria baicalensis extract 30%, notoginseng extract 20%;
Chinese medicine extract in experimental group 3 is made up of the component of following mass percentage: Rhizoma Coptidis extract 25%, Cortex Phellodendri extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%;
Chinese medicine extract in experimental group 4 is made up of the component of following mass percentage: Rhizoma Coptidis extract 30%, Cortex Phellodendri extract 25%, Scutellaria baicalensis extract 20%, notoginseng extract 25%;
Chinese medicine extract in experimental group 5 is made up of the component of following mass percentage: Rhizoma Coptidis extract 25%, Cortex Phellodendri extract 35%, Scutellaria baicalensis extract 30%, notoginseng extract 10%;
Chinese medicine extract in experimental group 6 is made up of the component of following mass percentage: Rhizoma Coptidis extract 35%, Cortex Phellodendri extract 20%, Scutellaria baicalensis extract 25%, notoginseng extract 20%;
Chinese medicine extract in experimental group 7 is made up of the component of following mass percentage: Rhizoma Coptidis extract 15%, Cortex Phellodendri extract 40%, Scutellaria baicalensis extract 15%, notoginseng extract 30%;
Chinese medicine extract in experimental group 8 is made up of the component of following mass percentage: Rhizoma Coptidis extract 35%, Cortex Phellodendri extract 15%, Scutellaria baicalensis extract 35%, notoginseng extract 15%.
The toothpaste that matched group adopts is except the hydroxypropyl-beta-cyclodextrin inclusion do not contained in toothpaste of the present invention, and the amount water consumption not containing hydroxypropyl-beta-cyclodextrin inclusion is supplied, and all the other compositions and content are all identical with the present invention.
1, the therapeutic effect of oral cavity gingivitis is tested
Random selecting 540 suffers from the patient of dental gingival inflammation, be divided into 9 groups at random, often organize 60 people, 9 groups of patients use the toothpaste of experimental group 1 ~ 8 and matched group respectively, and every day respectively once, adheres to 2 months sooner or later, then the situation often organizing patient is added up, what dental gingival inflammation took a favorable turn phenomenon is effective, and what dental gingival inflammation obtained medical treatment substantially is effective, and statistical result is as table 1:
Table 1
| Group | Number | Effective number | Efficiently individual quantity | Obvious effective rate | Effective percentage | Total treatment rate |
| Matched group | 60 | 0 | 0 | 0％ | 0％ | 0％ |
| Experimental group 1 | 60 | 36 | 18 | 60.00％ | 30.00％ | 90.00％ |
| Experimental group 2 | 60 | 31 | 19 | 51.67％ | 31.67％ | 83.33％ |
| Experimental group 3 | 60 | 41 | 18 | 68.33％ | 30.00％ | 98.33％ |
| Experimental group 4 | 60 | 34 | 21 | 56.67％ | 35.00％ | 91.67％ |
| Experimental group 5 | 60 | 36 | 20 | 60.00％ | 33.33％ | 93.33％ |
| Experimental group 6 | 60 | 35 | 19 | 58.33％ | 31.67％ | 90.00％ |
| Experimental group 7 | 60 | 34 | 18 | 56.67％ | 30.00％ | 86.67％ |
| Experimental group 8 | 60 | 33 | 17 | 55.00％ | 28.33％ | 83.33％ |
As seen from Table 1, experimental group is compared with matched group, experimental group generally has therapeutic effect to oral cavity gingivitis, and in experimental group, the effect of experimental group 1 and experimental group 3 ~ 6 pairs of oral cavity gingivitis is better than other experimental grouies, especially total treatment rate of experimental group 3 is the highest, has best therapeutic effect to oral cavity gingivitis.This also demonstrate the content of Rhizoma Coptidis and Cortex Phellodendri extract larger and the two content more close to time, described toothpaste is better to the therapeutic effect of oral cavity gingivitis.
2, the therapeutic effect of gingival hemorrhage is tested
Random selecting 504 suffers from the patient of gingival hemorrhage, be divided into 9 groups at random, often organize 56 people, 9 groups of patients use the toothpaste of experimental group 1 ~ 8 and matched group respectively, and every day respectively once, adheres to 2 months sooner or later, then the situation often organizing patient is added up, what gingival hemorrhage took a favorable turn phenomenon is effective, and what gingival hemorrhage obtained medical treatment substantially is effective, and statistical result is as table 2:
Table 2
| Group | Number | Effective number | Efficiently individual quantity | Obvious effective rate | Effective percentage | Total treatment rate |
| Matched group | 56 | 0 | 0 | 0％ | 0％ | 0％ |
| Experimental group 1 | 56 | 37 | 11 | 66.07％ | 19.64％ | 85.71％ |
| Experimental group 2 | 56 | 40 | 11 | 71.43％ | 19.64％ | 91.07％ |
| Experimental group 3 | 56 | 40 | 15 | 71.43％ | 26.79％ | 98.21％ |
| Experimental group 4 | 56 | 40 | 12 | 71.43％ | 21.43％ | 92.86％ |
| Experimental group 5 | 56 | 35 | 13 | 62.50％ | 23.21％ | 85.71％ |
| Experimental group 6 | 56 | 39 | 13 | 69.64％ | 23.21％ | 92.86％ |
| Experimental group 7 | 56 | 41 | 10 | 73.21％ | 17.86％ | 91.07％ |
| Experimental group 8 | 56 | 38 | 10 | 67.86％ | 17.86％ | 85.71％ |
As seen from Table 2, experimental group is compared with matched group, experimental group generally has therapeutic effect to gingival hemorrhage, and in experimental group, the effect of experimental group 2 ~ 4 and experimental group 6 ~ 7 pairs of gingival hemorrhages is better than other experimental grouies, especially total treatment rate of experimental group 3 is the highest, has best therapeutic effect to gingival hemorrhage.
3, the therapeutic effect of oral ulcer is tested
Random selecting 585 suffers from the patient of oral ulcer, be divided into 9 groups at random, often organize 65 people, 9 groups of patients use the toothpaste of experimental group 1 ~ 8 and matched group respectively, and every day respectively once, adheres to 2 months sooner or later, then the situation often organizing patient is added up, what oral ulcer took a favorable turn phenomenon is effective, and what oral ulcer obtained medical treatment substantially is effective, and statistical result is as table 3:
Table 3
| Group | Number | Effective number | Efficiently individual quantity | Obvious effective rate | Effective percentage | Total treatment rate |
| Matched group | 65 | 0 | 0 | 0％ | 0％ | 0％ |
| Experimental group 1 | 65 | 41 | 14 | 63.08％ | 21.54％ | 84.62％ |
| Experimental group 2 | 65 | 43 | 17 | 66.15％ | 26.15％ | 92.31％ |
| Experimental group 3 | 65 | 42 | 22 | 64.62％ | 33.85％ | 98.46％ |
| Experimental group 4 | 65 | 40 | 16 | 61.54％ | 24.62％ | 86.15％ |
| Experimental group 5 | 65 | 42 | 19 | 64.62％ | 29.23％ | 93.85％ |
| Experimental group 6 | 65 | 40 | 19 | 61.54％ | 29.23％ | 90.77％ |
| Experimental group 7 | 65 | 42 | 13 | 64.62％ | 20.00％ | 84.62％ |
| Experimental group 8 | 65 | 41 | 19 | 63.08％ | 29.23％ | 92.31％ |
As seen from Table 3, experimental group is compared with matched group, experimental group generally has therapeutic effect to oral ulcer, and in experimental group, the effect of experimental group 2 ~ 3, experimental group 5 ~ 6 and experimental group 8 pairs of oral ulcer is better than other experimental grouies, especially total treatment rate of experimental group 3 is the highest, has best therapeutic effect to oral ulcer.
From above-mentioned table 1 ~ 3, when the component of described Chinese medicine extract by following mass percentage forms: when Rhizoma Coptidis extract 25%, Cortex Phellodendri extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%, the therapeutic effect of described toothpaste to oral cavity gingivitis, gingival hemorrhage and oral ulcer is best.
Embodiment 11
Chinese medicine extraction species is tested the impact of toothpaste efficiency
This test is divided into 14 groups, often organize in toothpaste except the Chinese medicine extraction species in hydroxypropyl-beta-cyclodextrin inclusion is different, all the other compositions and content are all identical, are specially: the parts by weight of each component contained in every 100 parts of described toothpaste are: wetting agent 23 ~ 57 parts, binding agent 1 ~ 4 part, foaming agent 1.5 ~ 5.5 parts, abrasivus 12 ~ 60 parts, saccharin sodium 0.1 ~ 0.3 part, hydroxypropyl-beta-cyclodextrin inclusion 0.1 ~ 10 part, 0.8 ~ 2 part, essence, surplus are deionized water.The preparation method often organizing toothpaste is identical, all adopts the preparation method of toothpaste described in the present invention.
The Chinese medicine extraction species often contained in group is as shown in table 4:
Table 4
| Group | Rhizoma Coptidis extract | Cortex Phellodendri extract | Scutellaria baicalensis extract | Notoginseng extract |
| 1st group | Be | Be | Be | Be |
| 2nd group | Be | Be | Be | No |
| 3rd group | Be | Be | No | No |
| 4th group | Be | No | Be | No |
| 5th group | No | Be | Be | No |
| 6th group | Be | No | No | No |
| 7th group | No | Be | No | No |
| 8th group | No | No | Be | No |
| 9th group | Be | Be | No | Be |
| 10th group | Be | No | Be | Be |
| 11st group | No | Be | Be | Be |
| 12nd group | Be | No | No | Be |
| 13rd group | No | Be | No | Be |
| 14th group | No | No | Be | Be |
In table 4, "Yes" represents containing corresponding Chinese medicine extract, and "No" represents not containing corresponding Chinese medicine extract.
In the hydroxypropyl-beta-cyclodextrin inclusion of the 1st group, the mass ratio of Chinese medicine extract and HP-β-CD is 1:3 ~ 7, and Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 15 ~ 35%, Cortex Phellodendri extract 20 ~ 40%, Scutellaria baicalensis extract 15 ~ 35%, notoginseng extract 10 ~ 30%.The preparation method of described hydroxypropyl-beta-cyclodextrin inclusion adopts the method described in the present invention.
Identical with the component content of the 1st group and preparation method in 2nd ~ 14 groups, when not containing a certain Chinese medicine extract, substitute with the water of equivalent.
Choose 840 dental gingival inflammation patients respectively, 840 oral ulcer patients and 840 are gingival hemorrhage patient, then 14 groups are divided into all at random, often group is 60 people, have 60 dental gingival inflammation patients, 60 oral ulcer patients and 60 gingival hemorrhage patients in 1st group, 2nd ~ 14 groups all identical.1st ~ 14 groups use the toothpaste of in the present embodiment 1st ~ 14 groups (in the toothpaste of 1st ~ 14 groups respectively, except the kind of Chinese medicine extract in hydroxypropyl-beta-cyclodextrin inclusion is different, all the other are all identical), every day is respectively used once sooner or later, continuous use 3 months, statistics often organizes the situation of patient, take a favorable turn or what fully recover is effective, and statistical result is as shown in table 5:
Table 5
| Group | Dental gingival inflammation efficiently individual quantity | Oral ulcer efficiently individual quantity | Gingival hemorrhage efficiently individual quantity |
| 1st group | 55 | 54 | 54 |
| 2nd group | 56 | 53 | 0 |
| 3rd group | 12 | 15 | 0 |
| 4th group | 14 | 11 | 0 |
| 5th group | 12 | 13 | 0 |
| 6th group | 9 | 8 | 0 |
| 7th group | 7 | 8 | 0 |
| 8th group | 8 | 9 | 0 |
| 9th group | 15 | 12 | 53 |
| 10th group | 14 | 14 | 55 |
| 11st group | 11 | 13 | 52 |
| 12nd group | 7 | 9 | 53 |
| 13rd group | 10 | 6 | 52 |
| 14th group | 8 | 7 | 54 |
As seen from Table 5, simultaneously containing Rhizoma Coptidis extract, Cortex Phellodendri extract and Scutellaria baicalensis extract the 1st group and the 2nd group, to oral cavity gingivitis and oral ulcer, there is good therapeutic effect, and only containing Rhizoma Coptidis extract, any one or two kinds in Cortex Phellodendri extract and Scutellaria baicalensis extract 3rd ~ 14 groups, the therapeutic effect of oral cavity gingivitis and oral ulcer is reduced greatly, thus Rhizoma Coptidis is described, when Cortex Phellodendri and Radix Scutellariae three medicine share, synergism can be played, strengthen respective heat clearing away and internal heat reducing, effect of bacteriostat degerming, thus to oral cavity gingivitis, oral ulcer has significant therapeutic effect.In the toothpaste of the 1st group, 9th ~ 14 groups, due to containing notoginseng extract, to gingival hemorrhage, there is good therapeutic effect, and in the toothpaste of 2nd ~ 8 groups, because not containing notoginseng extract, therapeutic effect be there is no to gingival hemorrhage, can illustrate thus, in Chinese medicine toothpaste of the present invention, the Radix Notoginseng added can play effect of hemostasis by removing blood stasis, thus has good effect to treatment gingival hemorrhage.
Finally to should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention but not limiting the scope of the invention; although be explained in detail the present invention with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify to technical scheme of the present invention or equivalent replacement, and not depart from essence and the scope of technical solution of the present invention.
Claims (10)
1. a Chinese medicine toothpaste, it is characterized in that, containing hydroxypropyl-beta-cyclodextrin inclusion in described toothpaste, described hydroxypropyl-beta-cyclodextrin inclusion contains Chinese medicine extract and HP-β-CD, and the mass ratio of described Chinese medicine extract and HP-β-CD is 1:3 ~ 7;
Described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 15 ~ 35%, Cortex Phellodendri extract 20 ~ 40%, Scutellaria baicalensis extract 15 ~ 35%, notoginseng extract 10 ~ 30%.
2. Chinese medicine toothpaste as claimed in claim 1, it is characterized in that, described Rhizoma Coptidis extract adopts following methods to prepare: Rhizoma Coptidis was pulverized 60 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 55 DEG C, extracting pressure is 25 ~ 35mPa, and separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 0.5 ~ 2.5h, obtains Rhizoma Coptidis extract;
Described Cortex Phellodendri extract adopts following methods to prepare: Cortex Phellodendri was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 45 DEG C, and extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 0.5 ~ 2.5h, obtains Cortex Phellodendri extract;
Described Scutellaria baicalensis extract adopts following methods to prepare: Radix Scutellariae was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 50 DEG C, and extracting pressure is 25 ~ 35mPa, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 1.5 ~ 3.5h, obtains Scutellaria baicalensis extract;
Described notoginseng extract adopts following methods to prepare: Radix Notoginseng was pulverized 40 mesh sieves, be placed in supercritical extraction reactor, extraction temperature is 35 ~ 50 DEG C, extracting pressure is 25 ~ 35mPa, entrainer made by 95% ethanol, separator outlet blowing through cycling extraction and after keeping constant temperature and pressure 1.5 ~ 3.5h, obtains notoginseng extract.
3. Chinese medicine toothpaste as claimed in claim 1, it is characterized in that, the mass ratio of described Chinese medicine extract and HP-β-CD is 1:5.
4. Chinese medicine toothpaste as claimed in claim 1 or 2, it is characterized in that, described Chinese medicine extract is made up of the component of following mass percentage: Rhizoma Coptidis extract 25%, Cortex Phellodendri extract 30%, Scutellaria baicalensis extract 25%, notoginseng extract 20%.
5. Chinese medicine toothpaste as claimed in claim 1 or 2, is characterized in that, described hydroxypropyl-beta-cyclodextrin inclusion adopts following methods to be prepared from:
(1) HP-β-CD is mixed with saturated aqueous solution;
(2) Rhizoma Coptidis extract, Cortex Phellodendri extract, Scutellaria baicalensis extract and notoginseng extract are mixed, obtain Chinese medicine extract;
(3) joined in the saturated aqueous solution of step (1) by the Chinese medicine extract that step (2) obtains and carry out enclose, enclose temperature is 35 ~ 55 DEG C, stirs 1 ~ 3 hour, dry after filtering, and obtains hydroxypropyl-beta-cyclodextrin inclusion.
6. Chinese medicine toothpaste as claimed in claim 5, it is characterized in that, the enclose temperature in described step (3) is 45 DEG C, and mixing time is 2 hours.
7. Chinese medicine toothpaste as claimed in claim 1, it is characterized in that, the weight content of described hydroxypropyl-beta-cyclodextrin inclusion in toothpaste is 0.1 ~ 10%.
8. Chinese medicine toothpaste as claimed in claim 7, it is characterized in that, described toothpaste is also containing wetting agent, binding agent, foaming agent, abrasivus, saccharin sodium, essence and deionized water, and the parts by weight of each component contained in every 100 parts of described toothpaste are: wetting agent 18 ~ 57 parts, binding agent 0.8 ~ 4 part, foaming agent 1.5 ~ 5.5 parts, abrasivus 12 ~ 60 parts, saccharin sodium 0.1 ~ 0.3 part, hydroxypropyl-beta-cyclodextrin inclusion 0.1 ~ 10 part, 0.8 ~ 2 part, essence, surplus are deionized water; Preferably, the parts by weight of each component contained in every 100 parts of described toothpaste are: wetting agent 30 ~ 40 parts, binding agent 0.8 ~ 2 part, foaming agent 2 ~ 5 parts, abrasivus 26 ~ 35 parts, saccharin sodium 0.2 part, hydroxypropyl-beta-cyclodextrin inclusion 0.8 ~ 5 part, 1 ~ 1.5 part, essence, surplus are deionized water; Most preferably, the parts by weight of each component contained in every 100 parts of described toothpaste are: wetting agent 38 parts, binding agent 1 part, foaming agent 2.5 parts, abrasivus 28 parts, saccharin sodium 0.2 part, hydroxypropyl-beta-cyclodextrin inclusion 1.2 parts, 1.2 parts, essence, surplus are deionized water.
9. Chinese medicine toothpaste as claimed in claim 8, it is characterized in that, described wetting agent is at least one in sorbitol, PEG-8, glycerol; Described binding agent is at least one in sodium carboxymethyl cellulose, HANSHENGJIAO; Described foaming agent is at least one in sodium lauryl sulphate, sodium lauroyl sarcosine; Described abrasivus is at least one in calcium carbonate, silicon dioxide; Described essence is food stage essence.
10. Chinese medicine toothpaste as claimed in claim 8 or 9, it is characterized in that, described toothpaste is adopted and is prepared from the following method:
(1) wetting agent, binding agent, foaming agent, abrasivus, saccharin sodium and deionized water are mixed, keep vacuum at-0.09Mpa ~-0.096Mpa, stir;
(2) add essence and hydroxypropyl-beta-cyclodextrin inclusion, keep vacuum at-0.09Mpa ~-0.096Mpa, stir, obtain Chinese medicine toothpaste.
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| CN112691056A (en) * | 2021-03-24 | 2021-04-23 | 赵新辉 | Preparation process of medicinal toothpaste for reducing internal heat |
| WO2021106901A1 (en) * | 2019-11-29 | 2021-06-03 | ライオン株式会社 | Oral liquid composition |
| CN114469794A (en) * | 2020-10-28 | 2022-05-13 | 南京中科游子生物技术研究院有限公司 | Green tea active substance mouthwash composition and preparation method thereof |
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