CN103893381B - Composition with lead-expelling function and its preparation method and application - Google Patents
Composition with lead-expelling function and its preparation method and application Download PDFInfo
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- CN103893381B CN103893381B CN201210581101.3A CN201210581101A CN103893381B CN 103893381 B CN103893381 B CN 103893381B CN 201210581101 A CN201210581101 A CN 201210581101A CN 103893381 B CN103893381 B CN 103893381B
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Abstract
The invention provides a kind of composition with lead-expelling function, the raw material of the composition includes cassia seed, chrysanthemum, pawpaw, matrimony vine.Present invention full utilization traditional Chinese medicinal material raw materials, fully extract effective active matter, clear liver and improve vision, tonifying lung invigorating the spleen, dispelling wind and heat from the body, clearing heat and detoxicating effect are extracted to the active component in raw material, built up health so as to reach, prophylactic healthcare function；Production technology is scientific and reasonable, simple to operation, and product quality is stable, controllable.
Description
Technical field
The present invention relates to a kind of composition with lead-expelling function and preparation method thereof.
Background technology
Lead is a kind of heavy metal element on human body with the influence of systemic, multisystem, to the affinity of tissue very
By force, the multiple organ injury disease such as liver, brain can be caused.Lead be easy to accumulate for a long time by blood the liver,kidney,spleen in people, lung and
In brain, so as to cause the intellectual developmental disorder and hemochrome of people to raise obstacles.Infringement of the lead to children is higher than adult, if
Prevent and treat not in time, serious harm can be produced to the intelligence of children, behavior, ability and other physical functions, or even to children not
To exert far reaching influence.
With the development of modern industry, lead contamination and harm are increasingly paid attention to by people.Increasing people starts to cause
Power is in the research and development of the product with lead-expelling function.
The content of the invention
To solve the deficiencies in the prior art, the present invention provides a kind of composition with lead-expelling function.Said composition is main
Appropriate auxiliary material is added as raw material using cassia seed, chrysanthemum, pawpaw, matrimony vine, remaining is water.The present invention make full use of cassia seed, chrysanthemum,
Pawpaw, matrimony vine clear liver and improve vision, tonifying lung invigorating the spleen, dispelling wind and heat from the body, clearing heat and detoxicating effect, solve the internal heavy metal element of promotion
The problem of excretion of lead, by extracting the active component in raw material, be conducive to taking the absorption with body.
It is a primary object of the present invention to provide a kind of composition with lead-expelling function, the raw material of the composition includes
Cassia seed 5-20%, chrysanthemum 30-70%, pawpaw 10-30%, matrimony vine 10-30%.
Cassia seed bitter, it is sweet, into, cold nature, high fat of blood, hypertension are treated in enter liver, kidney, lipid-loweringing improving eyesight.Clear liver and improve vision,
Sharp water defaecation, there is laxative action, reducing blood pressure and blood fat.With good greasy effect of toxin expelling oil extraction.
Chrysanthemum has tonifying lung invigorating the spleen, effect of wind dispelling fortune poison.It can strengthen cellular immunity, and increase spleen protein matter is closed
Into promoting spleen cell hyperplasia.Chrysanthemum can strengthen the energetic supersession of cardiac muscle cell so as to the heart to poisoning or Fatigue failure
Effect is more obvious.
Pawpaw is sour, puckery, warm-natured, have the title of " hundred beneficial fruit kings ".Pawpaw have hundred benefit and a damage, so ancient poetry is said, throw it
With pawpaw, report with delicious wine.
Matrimony vine is rich in multiple nutritional components such as matrimony vine proteoglycan, vitamin C, phosphorus, iron, to hemopoietic function of bone marrow and items
Immunological Markers for Cell-Mediated Immunity has obvious humidification, can significantly improve the superoxide dismutase (SOD) of body blood, liver and muscular tissue
Active quantities, so as to be conducive to the removing of active oxygen.
Another object of the present invention is to provide a kind of method for preparing described composition, methods described includes：
1) the various raw materials, plus the water of 10 times of amounts is proportionally taken to soak；
2) raw material infiltrated is boiled at 60 DEG C and carried 3 hours, filtered, obtain filtrate 1；
3) according to step 2) methods described, then extract once, obtain filtrate 2；
4) filtrate 1 and filtrate 2, the filtrate centrifuge are merged, supernatant is the Chinese medicine extract；
5) Chinese medicine extract, spray drying are concentrated.
Preferably, methods described further comprises post-processing step：The extract of the drying is prepared into pharmacy
Preparation, the preparation include pill, tablet, capsule, granule or powder preparation to be taken after being infused in boiling water, aqua or oral liquid.
It is still another object of the present invention to provide application of the composition in the medicine with lead-expelling function is prepared.
A further object of the present invention is to provide application of the composition in the food with lead-expelling function is prepared.
The a further object of the present invention is application of the composition in the health products with lead-expelling function are prepared.
Present invention full utilization traditional Chinese medicinal material raw materials, fully extract effective active matter, clear liver and improve vision, tonifying lung invigorating the spleen, evacuation
Wind-heat, clearing heat and detoxicating effect, extract to the active component in raw material, are built up health so as to reach, prophylactic to protect
Health-care function；Production technology is scientific and reasonable, simple to operation, and product quality is stable, controllable.
Embodiment
For the feature and other purposes of the present invention can be further appreciated that, described in detail such as in conjunction with appended preferred embodiment
Under, embodiment is merely to illustrate technical scheme, and the non-limiting present invention.
Prepare embodiment 1：The present embodiment prepares composition according to following steps：
1st, by weight percentage, pine torch 20% is depended on, chrysanthemum 40%, pawpaw 20%, 20% 4 kind of primary raw material of matrimony vine,
Removing impurity is eluted with water respectively, is soaked 2 hours in the water of 25 DEG C plus 10 times amounts of room temperature.
2nd, the Chinese medicine infiltrated is put into extractor, 60 DEG C are boiled and carry 3 hours.Filtering, obtains filtrate 1.
3rd, ibid method, then extract once, obtains filtrate 2.
4th, filter, collecting decoction, remove residue, filtrate centrifuge obtains supernatant.
5th, supernatant is taken to obtain the Chinese medicine extract.Enter spraying when being concentrated into relative density 1.05-1.06 (60 DEG C) dry
Dry device, obtains spray dried powder standby.
6th, can be made any conventional oral preparations in pharmacy according to actual needs, such as pill, tablet, capsule,
Granule or powder preparation to be taken after being infused in boiling water, aqua or oral liquid.
Prepare embodiment 2：The present embodiment prepares composition according to following steps：
1st, by weight percentage, pine torch 10% is depended on, chrysanthemum 50%, pawpaw 30%, 10% 4 kind of primary raw material of matrimony vine,
Removing impurity is eluted with water respectively, is soaked 2 hours in the water of 25 DEG C plus 10 times amounts of room temperature.
2nd, the Chinese medicine infiltrated is put into extractor, 60 DEG C are boiled and carry 3 hours.Filtering, obtains filtrate 1.
3rd, ibid method, then extract once, obtains filtrate 2.
4th, filter, collecting decoction, remove residue, filtrate centrifuge obtains supernatant.
5th, supernatant is taken to obtain the Chinese medicine extract.Enter spraying when being concentrated into relative density 1.05-1.06 (60 DEG C) dry
Dry device, obtains spray dried powder standby.
6th, can be made any conventional oral preparations in pharmacy according to actual needs, such as pill, tablet, capsule,
Granule or powder preparation to be taken after being infused in boiling water, aqua or oral liquid.
Prepare embodiment 3：The present embodiment prepares composition according to following steps：
1st, by weight percentage, pine torch 15% is depended on, chrysanthemum 60%, pawpaw 10%, 15% 4 kind of primary raw material of matrimony vine,
Removing impurity is eluted with water respectively, is soaked 2 hours in the water of 25 DEG C plus 10 times amounts of room temperature.
2nd, the Chinese medicine infiltrated is put into extractor, 60 DEG C are boiled and carry 3 hours.Filtering, obtains filtrate 1.
3rd, ibid method, then extract once, obtains filtrate 2.
4th, filter, collecting decoction, remove residue, filtrate centrifuge obtains supernatant.
5th, supernatant is taken to obtain the Chinese medicine extract.Enter spraying when being concentrated into relative density 1.05-1.06 (60 DEG C) dry
Dry device, EAT controls 140-160 DEG C, and 100-110 DEG C of leaving air temp, charging rate is 3-6ml/ minutes, must be spray-dried
Powder is standby.
6th, can be made any conventional oral preparations in pharmacy according to actual needs, such as pill, tablet, capsule,
Granule or powder preparation to be taken after being infused in boiling water, aqua or oral liquid.
Embodiment 4：
The present embodiment is detected according to following steps to each active ingredient in composition：
Composition Content of Chlorogenic Acid is determined at 330nm with ultraviolet spectrophotometer method；
Composition general flavone content is determined at 510nm with ultraviolet spectrophotometer method；
Composition polyoses content is determined at 485nm with ultraviolet spectrophotometer method；
Each active component detection in the composition of table 1
| Sample 1 | Sample 2 | Sample 3 | |
| Chrysanthemum (%) | 40 | 50 | 60 |
| Pawpaw (%) | 20 | 30 | 10 |
| Matrimony vine (%) | 20 | 10 | 15 |
| Cassia seed (%) | 20 | 10 | 15 |
| Chlorogenic acid content (%) | 0.79 | 1.04 | 1.24 |
| Polyoses content (%) | 8.20 | 6.04 | 5.84 |
| General flavone content (%) | 0.84 | 1.02 | 1.24 |
Above-mentioned each component organic assembling, is supported mutually, with improving body blood, strengthen cellular immunity, promote cell to increase
Raw effect, the present invention, which has, prevents and treats dual-purpose, ill disease-free health care of curing the disease.
Embodiment 5
The composition prepared in embodiment 1~3 is prepared through zoopery, good result is achieved：
This product does zoopery：
Healthy mice 20, body weight 110-130g is raised in 22-27 DEG C of temperature, relative humidity is 40-70%, freely
Water inlet, feed, it is 8h that light application time is carried out daily, carries out adaptability raising.
Test method：Adaptability is raised after week age, and 30 white mouse are divided into 3 groups, every group each 10.Two groups of white mouse are every
It drinks 0.5g/L lead acetate water solution, continues two time-of-weeks, and high lead mouse models successfully, and the 3rd group is blank control group.With reality
Apply example 1 and continuously take with blank to compare after 60 days to experimental animal group and compare, as a result lead in the blood lead content and hepatic tissue of white mouse
Content is below model control group, and its difference has conspicuousness (P ＜ 0.05).Specific data are shown in Table 2：
Influence of the present invention of table 2 to white mouse blood lead, liver lead content
| Group | Dosage (g/kg) | Blood lead (mg/kg) | Liver lead (mg/kg) |
| Blank control | 0.0 | 0.08±0.03 | 1.0±0.02 |
| Model comparison | 0.0 | 2.0±0.02 | 2.9±0.68 |
| Administration group | 20 | 1.2±0.04 | 1.9±0.34 |
Test result indicates that the present invention can significantly reduce the lead content in high lead stamp type white mouse body, the present invention has lead discharging
Function.
It is to be understood that, foregoing invention content and embodiment are intended to prove technical scheme provided by the present invention
Practical application, should not be construed as limiting the scope of the present invention.Those skilled in the art are in spirit and principles of the present invention
It is interior, when can various modifications may be made, equivalent substitution or improve.Protection scope of the present invention is defined by appended claims.
Claims (7)
1. a kind of composition with lead-expelling function, the raw material of the composition is by cassia seed 5-20%, chrysanthemum 30-70%, wood
Melon 10-30%, matrimony vine 10-30% are constituted.
2. a kind of method of the composition prepared described in claim 1, methods described includes：
1) the various raw materials, plus the water of 10 times of amounts is proportionally taken to soak；
2) raw material infiltrated is boiled at 60 DEG C and carried 3 hours, filtered, obtain filtrate 1；
3) according to step 2) methods described, then extract once, obtain filtrate 2；
4) filtrate 1 and filtrate 2, the filtrate centrifuge are merged, supernatant is the Chinese medicine extract；
5) Chinese medicine extract, spray drying are concentrated.
3. preparation method according to claim 2, methods described further comprises post-processing step：By carrying for the drying
Thing is taken to be prepared into the preparation in pharmacy, the preparation includes pill, tablet, capsule, aqua.
4. the aqua in preparation method according to claim 3, the preparation is granule or powder preparation to be taken after being infused in boiling water or oral liquid.
5. application of the composition in the medicine with lead-expelling function is prepared according to claim 1.
6. application of the composition in the food with lead-expelling function is prepared according to claim 1.
7. application of the composition in the health products with lead-expelling function are prepared according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210581101.3A CN103893381B (en) | 2012-12-28 | 2012-12-28 | Composition with lead-expelling function and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210581101.3A CN103893381B (en) | 2012-12-28 | 2012-12-28 | Composition with lead-expelling function and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103893381A CN103893381A (en) | 2014-07-02 |
| CN103893381B true CN103893381B (en) | 2017-10-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210581101.3A Active CN103893381B (en) | 2012-12-28 | 2012-12-28 | Composition with lead-expelling function and its preparation method and application |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105192599A (en) * | 2015-08-14 | 2015-12-30 | 慧谷生命科技湖北有限公司 | Lead removing particles and preparation method thereof |
| CN107648376A (en) * | 2017-10-24 | 2018-02-02 | 宁国平衡健康管理有限公司 | A kind of solid beverage for promoting lead discharging and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456210A (en) * | 2003-01-14 | 2003-11-19 | 江西江中药业股份有限公司 | Products for promoting human lead discharge and preparing method thereof |
| CN102144688A (en) * | 2011-02-11 | 2011-08-10 | 上海智茗实业有限公司 | Solid instant tea containing Longjing tea |
-
2012
- 2012-12-28 CN CN201210581101.3A patent/CN103893381B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456210A (en) * | 2003-01-14 | 2003-11-19 | 江西江中药业股份有限公司 | Products for promoting human lead discharge and preparing method thereof |
| CN102144688A (en) * | 2011-02-11 | 2011-08-10 | 上海智茗实业有限公司 | Solid instant tea containing Longjing tea |
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| Publication number | Publication date |
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| CN103893381A (en) | 2014-07-02 |
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Effective date of registration: 20170427 Address after: 100000 Changan, Dongcheng District, East Chang'an Avenue, No. 708 building, room, room 10 Applicant after: Beijing Fuwah Andre Bio-pharmaceutical Technology Development Co., Ltd. Address before: 050800 Shijiazhuang science and technology center, No. 136 the Yellow River Avenue, Shijiazhuang high tech Zone,, China, 6 Applicant before: SHIJIAZHUANG LAIWA & FERID BIOTECHNOLOGY INC. |
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Effective date of registration: 20180801 Address after: 100006 room 708, Chang'an mansion 10, East Chang'an Street, Dongcheng District, Beijing. Patentee after: Beijing, Germany bio pharmaceutical Polytron Technologies Inc Address before: 100000 room 708, Changan building, 10 East Chang'an Avenue, Dongcheng District, Beijing. Patentee before: Beijing Fuwah Andre Bio-pharmaceutical Technology Development Co., Ltd. |
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Address after: Room G5, Ground Floor, Chang'an Building, 10 East Chang'an Street, Dongcheng District, Beijing 100006 Patentee after: Beijing, Germany bio pharmaceutical Polytron Technologies Inc Address before: 100006 room 708, Chang'an mansion 10, East Chang'an Street, Dongcheng District, Beijing. Patentee before: Beijing, Germany bio pharmaceutical Polytron Technologies Inc |
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