CN109957038A - A kind of preparation method of Radix Glycyrrhizae Thick many candies - Google Patents
A kind of preparation method of Radix Glycyrrhizae Thick many candies Download PDFInfo
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- CN109957038A CN109957038A CN201910200603.9A CN201910200603A CN109957038A CN 109957038 A CN109957038 A CN 109957038A CN 201910200603 A CN201910200603 A CN 201910200603A CN 109957038 A CN109957038 A CN 109957038A
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- radix glycyrrhizae
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- many candies
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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- Food Science & Technology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of preparation methods of Radix Glycyrrhizae Thick many candies, comprising the following steps: by glycyrrhiza extract progress water extraction soluble in water, filters to take the liquid after solid-liquid is layered, stands overnight, centrifuging and taking supernatant；It is 10 ~ 15% that supernatant, which is concentrated under reduced pressure into water content, and the ethyl alcohol that volume fraction is 95 ~ 98% is slowly added dropwise into concentrate and quickly stirs, filters after refrigeration and takes filter cake, dry to remove extra ethyl alcohol to get Radix Glycyrrhizae Thick many candies；The present invention makes full use of the waste in industrial production, extracts Radix Glycyrrhizae Thick many candies, and be applied to animal farming industry, reduces or abandon antibacterials, improve the immune function of animal, reduce the illness probability of animal, provide green"meat product for the mankind.
Description
Technical field
The invention belongs to technical field of polysaccharide extraction, and in particular to a kind of preparation method of Radix Glycyrrhizae Thick many candies.
Background technique
Glycyrrhiza perennial herb, root is sturdy with rhizomes, is a kind of help Chinese herbal medicine, and sandy beach, grassland, main product are born in happiness
In Xinjiang, Gansu, Inner Mongol, Shanxi and other places, it is one of common Chinese herbal medicine of tradition, is commonly called as " kings of many medicines ", is used as medicine and has long go through
History.The main active of Radix Glycyrrhizae be licoflavone class and glycyrrhizin constituents, wherein flavones ingredient mainly have liquiritin,
Isoliquiritin, glycyrrhizin and isoliquiritigenin etc., glycyrrhizin constituents be mainly glycyrrhizic acid, licorice polysaccharide, Saponin G 2 and
Uralsaponin B etc.；Flavonoids is mainly dissolved in that organic solvent is not soluble in water, and licorice polysaccharide is dissolved in water, insoluble in organic molten
Agent.
Licorice polysaccharide is a kind of natural plant polyose, has antiviral, immunological regulation and antitumor activity, is had bright
Aobvious antiviral effect, to I herpes simplex virus type, vesicular stomatitis virus, III type of adenovirus, vaccinia virus, AIDS virus
There is inhibiting effect, is especially 36.2% to the inhibiting rate of AIDS virus；Immunoregulation effect is mainly reflected in netted to mouse
The influence of mononuclear phagocyte system function in endothelial system can also activate static mice spleen lymphocytes proliferation effect and resist
Complement activity etc.；Licorice polysaccharide can individually or collaboration chemotherapeutic collective effect is in tumour cell.
Animals and human beings class is the same, and imbalance, variation when the influence or body itself for receiving extraneous various factors, just having can
It can occur disease, or even dead, to improve survival rate, antibiotic is made that husbandry sector since the forties in last century huge
Contribution.In recent years, with the rise of concept of health, abuse of antibiotics bring a series of problems occurs therewith, with green,
The popularization of safety food, it is desirable to safer and more effective feed addictives to replace antibiotic imperative.And licorice polysaccharide
As a kind of pure natural Green medicament, energy disease preventing and treating, and the immune function of animal itself can be improved, give full play to animal and exempt from
Epidemic disease function, Small side effects, livestock and poultry use are not likely to produce drug resistance and residual, it is considered to be the ideal substitute of antibiotic.
Recent domestic scholar has many research to licorice polysaccharide and its auxiliary product, and licorice polysaccharide is as Radix Glycyrrhizae
One of main component, but fail to be fully used for many years, have Radix Glycyrrhizaes of the number in terms of ten thousand tons every year, only extract glycyrrhizic acid powder
Or after tanning extract of licorice root, will all discardings of remaining tens of thousands of tons of glycyrrhiza extracts, cause the great wasting of resources, however lose at these
In the glycyrrhiza extract of abandoning, most conservative estimation can also prepare the Radix Glycyrrhizae Thick many candies of kiloton, in Radix Glycyrrhizae Thick many candies, mainly contain with sweet
Grass polysaccharide is also to contain some flavone compounds, therefore referred to as Thick many candies outside the ingredient of primary efficacy.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of preparation method of Radix Glycyrrhizae Thick many candies, makes full use of industrial life
Waste in production extracts Radix Glycyrrhizae Thick many candies, and is applied to animal farming industry, reduces or abandon antibacterials, improves animal
Immune function, reduce the illness probability of animal, provide green"meat product for the mankind.
Technical solution provided by the present invention is as follows:
A kind of preparation method of Radix Glycyrrhizae Thick many candies, the liquid by glycyrrhiza extract progress water extraction soluble in water, after filtering to take solid-liquid layering
Body is stood overnight, centrifuging and taking supernatant；It is 10 ~ 15% that supernatant, which is concentrated under reduced pressure into water content, is slowly dripped into concentrate
Add the ethyl alcohol that volume fraction is 95 ~ 98% and quickly stir, is filtered after refrigeration and take filter cake, it is dry to remove extra ethyl alcohol to get sweet
Careless Thick many candies.
Preferably, the method that the water extracts are as follows: glycyrrhiza extract is dissolved in the water of decaploid product, normal pressure boil extraction 2 ~
2.5h, it is spare to filter out digestion liquid, and filter residue continues plus 1 ~ 1.5h is boiled in water logging, filters out digestion liquid, merges all digestion liquid.
Preferably, the method that the water extracts are as follows: glycyrrhiza extract is dissolved in the water of decaploid product, normal pressure boil extraction 3 ~
3.5h, it is spare to filter out digestion liquid, repeats this operation 3 times, and wherein boiling time is respectively 3 ~ 3.5h, 2 ~ 2.5h, 1 ~ 1.5h, merges
All digestion liquid.
Preferably, the method that the water extracts are as follows: glycyrrhiza extract is dissolved in the water of decaploid product, it is ultrasonic extraction 2 ~ 3 times, quiet
Liquid after taking solid-liquid to be layered after setting overnight.
It is highly preferred that ultrasonic temperature is 60 ~ 70 DEG C, each ultrasonic time is 30 ~ 40min.
Preferably, the glycyrrhiza extract is the glycyrrhiza extract extracted after extract of licorice root and glycol ethanol soluble object.
Preferably, the glycyrrhiza extract is to have extracted the glycyrrhiza extract after glycyrrhizic acid powder.
Preferably, centrifugal rotational speed is 5000 ~ 8000r/min, and centrifugation time is 30 ~ 40min.
The invention also discloses the Radix Glycyrrhizae Thick many candies for using any of the above-described preparation method to obtain to produce animal feed additive
Application.
Compared with prior art, the present invention has following technical advantage:
(1) present invention proposes the preparation method with alcohol extracting by simple water, can obtain the higher Radix Glycyrrhizae Thick many candies of purity, reduces
Impurity such as fat, protein, tannin, polyphenol, resin, mucilaginous substance macromolecular substances and solia particle is effective in extract
Removal, the licorice polysaccharide effective component extracted needed for retaining, greatly reduces the production cost of Radix Glycyrrhizae Thick many candies, is suitble to large area
It promotes；
(2) present invention makes full use of the waste in industrial production, extracts Radix Glycyrrhizae Thick many candies, raw material sources are extensive, by it
Applied to animal farming industry, antibacterials can be effectively reduced or be abandoned, improve the immune function of animal, the illness for reducing animal is several
Rate provides green"meat product for the mankind.
Specific embodiment
Now in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
A kind of preparation method of Radix Glycyrrhizae Thick many candies will extract the glycyrrhiza extract after extract of licorice root and glycol ethanol soluble object and be dissolved in ten
Normal pressure, which boils, in the water of times volume extracts 2h, filters out that digestion liquid is spare, and filter residue continues plus 1h is boiled in water logging, filters out digestion liquid, merges
All digestion liquid filters digestion liquid, removes filter residue, and filtrate stands overnight, and 5000r/min centrifugation 30min takes supernatant；It will be upper
It is 10% that clear liquid, which is concentrated under reduced pressure into water content, and the ethyl alcohol that volume fraction is 95% is slowly added dropwise into concentrate and quickly stirs,
It is filtered after refrigeration and takes filter cake, dry to remove extra ethyl alcohol to get Radix Glycyrrhizae Thick many candies, which can be used as additive and answer
In animal feed.
Embodiment 2
A kind of preparation method of Radix Glycyrrhizae Thick many candies will extract the glycyrrhiza extract after extract of licorice root and glycol ethanol soluble object and be dissolved in ten
Normal pressure, which boils, in the water of times volume extracts 3h, and it is spare to filter out digestion liquid, repeats this operation 3 times, wherein boiling time be respectively 3h,
2h, 1h merge all digestion liquid, filter digestion liquid, remove filter residue, and filtrate stands overnight, and 6000r/min centrifugation 35min takes
Supernatant；It is 11% that supernatant, which is concentrated under reduced pressure into water content, and the ethyl alcohol that volume fraction is 96% is slowly added dropwise into concentrate
And quickly stir, it is filtered after refrigeration and takes filter cake, dry to remove extra ethyl alcohol to get Radix Glycyrrhizae Thick many candies, which can
As additive application in animal feed.
Embodiment 3
A kind of preparation method of Radix Glycyrrhizae Thick many candies will extract the glycyrrhiza extract after extract of licorice root and glycol ethanol soluble object and be dissolved in ten
In the water of times volume, 60 DEG C ultrasonic extraction 2 times, each ultrasound 30min, the liquid after taking solid-liquid to be layered after standing overnight filters
Filter residue is removed, filtrate stands overnight, and 8000r/min centrifugation 38min takes supernatant；Supernatant, which is concentrated under reduced pressure into water content, is
12%, the ethyl alcohol that volume fraction is 97% is slowly added dropwise into concentrate and quickly stirs, is filtered after refrigeration and takes filter cake, drying is gone
Except extra ethyl alcohol is to get Radix Glycyrrhizae Thick many candies, which can be used as additive application in animal feed.
Embodiment 4
A kind of preparation method of Radix Glycyrrhizae Thick many candies is dissolved in normal pressure in the water of decaploid product for the glycyrrhiza extract after glycyrrhizic acid powder has been extracted
It boils and extracts 2.5h, it is spare to filter out digestion liquid, and filter residue continues plus 1.5h is boiled in water logging, and digestion liquid is filtered out, all digestion liquid is merged,
Digestion liquid is filtered, filter residue is removed, filtrate stands overnight, and 6000r/min centrifugation 30min takes supernatant；Supernatant is concentrated under reduced pressure
It is 13% to water content, the ethyl alcohol that volume fraction is 98% is slowly added dropwise into concentrate and quickly stirs, filters and takes after refrigeration
Filter cake, dry to remove extra ethyl alcohol to get Radix Glycyrrhizae Thick many candies, which can be used as additive application in animal feed
In.
Embodiment 5
A kind of preparation method of Radix Glycyrrhizae Thick many candies is dissolved in normal pressure in the water of decaploid product for the glycyrrhiza extract after glycyrrhizic acid powder has been extracted
It boils and extracts 3.5h, it is spare to filter out digestion liquid, repeats this operation 3 times, and wherein boiling time is respectively 3.5h, 2.5h, 1.5h, closes
And all digestion liquid, digestion liquid is filtered, filter residue is removed, filtrate stands overnight, and 8000r/min centrifugation 30min takes supernatant；It will
It is 14% that supernatant, which is concentrated under reduced pressure into water content, and the ethyl alcohol that volume fraction is 95% is slowly added dropwise into concentrate and quickly stirs
It mixes, is filtered after refrigeration and take filter cake, dry to remove extra ethyl alcohol to get Radix Glycyrrhizae Thick many candies, which can be used as addition
Agent is applied in animal feed.
Embodiment 6
A kind of preparation method of Radix Glycyrrhizae Thick many candies will have been extracted the glycyrrhiza extract after glycyrrhizic acid powder and has been dissolved in the water of decaploid product, and 70
DEG C ultrasonic extraction 2 times, each ultrasound 40min, the liquid after solid-liquid layering is taken after standing overnight is filtered to remove filter residue, filtrate is quiet
It sets overnight, 7000r/min centrifugation 36min takes supernatant；It is 15% that supernatant, which is concentrated under reduced pressure into water content, is delayed into concentrate
The ethyl alcohol that volume fraction is 98% is slowly added dropwise and quickly stirs, is filtered after refrigeration and takes filter cake, it is dry to remove extra ethyl alcohol, i.e.,
Radix Glycyrrhizae Thick many candies are obtained, which can be used as additive application in animal feed.
Claims (9)
1. a kind of preparation method of Radix Glycyrrhizae Thick many candies, it is characterised in that the following steps are included: by glycyrrhiza extract carry out water soluble in water
It extracts, the liquid after filtering to take solid-liquid layering is stood overnight, centrifuging and taking supernatant；Supernatant, which is concentrated under reduced pressure into water content, is
10 ~ 15%, the ethyl alcohol that volume fraction is 95 ~ 98% is slowly added dropwise into concentrate and quickly stirs, is filtered after refrigeration and takes filter cake,
It is dry to remove extra ethyl alcohol to get Radix Glycyrrhizae Thick many candies.
2. a kind of preparation method of Radix Glycyrrhizae Thick many candies according to claim 1, it is characterised in that: the method that the water extracts
Are as follows: glycyrrhiza extract is dissolved in the water of decaploid product, normal pressure boils 2 ~ 2.5h of extraction, and it is spare to filter out digestion liquid, and filter residue continues plus water
1 ~ 1.5h of digestion filters out digestion liquid, merges all digestion liquid.
3. a kind of preparation method of Radix Glycyrrhizae Thick many candies according to claim 1, it is characterised in that: the method that the water extracts
Are as follows: glycyrrhiza extract is dissolved in the water of decaploid product, normal pressure boils 3 ~ 3.5h of extraction, and it is spare to filter out digestion liquid, repeats this operation 3
Secondary, wherein boiling time is respectively 3 ~ 3.5h, 2 ~ 2.5h, 1 ~ 1.5h, merges all digestion liquid.
4. a kind of preparation method of Radix Glycyrrhizae Thick many candies according to claim 1, it is characterised in that: the method that the water extracts
Are as follows: glycyrrhiza extract is dissolved in the water of decaploid product, ultrasonic extraction 2 ~ 3 times, the liquid after taking solid-liquid to be layered after standing overnight.
5. a kind of preparation method of Radix Glycyrrhizae Thick many candies according to claim 4, it is characterised in that: ultrasonic temperature is 60 ~ 70
DEG C, each ultrasonic time is 30 ~ 40min.
6. a kind of preparation method of Radix Glycyrrhizae Thick many candies according to claim 1, it is characterised in that: the glycyrrhiza extract is to have mentioned
Glycyrrhiza extract after extracting liquorice medicinal extract and glycol ethanol soluble object.
7. a kind of preparation method of Radix Glycyrrhizae Thick many candies according to claim 1, it is characterised in that: the glycyrrhiza extract is to have mentioned
Glycyrrhiza extract after extracting liquorice acid powder.
8. a kind of preparation method of Radix Glycyrrhizae Thick many candies according to claim 1, it is characterised in that: centrifugal rotational speed be 5000 ~
8000r/min, centrifugation time are 30 ~ 40min.
9. according to claim 1 to Radix Glycyrrhizae Thick many candies answering in animal feed additive made from any one of 8 preparation methods
With.
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| CN201910200603.9A CN109957038A (en) | 2019-03-16 | 2019-03-16 | A kind of preparation method of Radix Glycyrrhizae Thick many candies |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110521861A (en) * | 2019-09-23 | 2019-12-03 | 李仁� | A kind of Radix Glycyrrhizae Thick many candies extract preparation and application as feed addictive |
| CN115677875A (en) * | 2022-11-23 | 2023-02-03 | 深圳市恒云生物科技有限公司 | A method for extracting Glycyrrhiza polysaccharide, glycyrrhiza polysaccharide and essence |
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| CN102532338A (en) * | 2012-01-16 | 2012-07-04 | 宁夏医科大学 | Ultrasonic extraction method of glycyrrhiza polysaccharide |
| CN103073655A (en) * | 2013-02-06 | 2013-05-01 | 乌鲁木齐英赛特生物科技有限公司 | Extraction method of glycyrrhiza polysaccharide and application |
| CN108586629A (en) * | 2018-05-15 | 2018-09-28 | 张淑红 | A kind of extracting method of licorice polysaccharide and its application in poultry produces |
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2019
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Patent Citations (3)
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| CN102532338A (en) * | 2012-01-16 | 2012-07-04 | 宁夏医科大学 | Ultrasonic extraction method of glycyrrhiza polysaccharide |
| CN103073655A (en) * | 2013-02-06 | 2013-05-01 | 乌鲁木齐英赛特生物科技有限公司 | Extraction method of glycyrrhiza polysaccharide and application |
| CN108586629A (en) * | 2018-05-15 | 2018-09-28 | 张淑红 | A kind of extracting method of licorice polysaccharide and its application in poultry produces |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110521861A (en) * | 2019-09-23 | 2019-12-03 | 李仁� | A kind of Radix Glycyrrhizae Thick many candies extract preparation and application as feed addictive |
| CN115677875A (en) * | 2022-11-23 | 2023-02-03 | 深圳市恒云生物科技有限公司 | A method for extracting Glycyrrhiza polysaccharide, glycyrrhiza polysaccharide and essence |
| CN115677875B (en) * | 2022-11-23 | 2024-01-26 | 深圳市恒云生物科技有限公司 | Licorice polysaccharide extraction process, licorice polysaccharide and essence |
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Application publication date: 20190702 |