CN108057039A - A kind of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition and preparation method and application - Google Patents
A kind of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition and preparation method and application Download PDFInfo
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Abstract
A kind of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition and preparation method and application, are related to dendrobium candidum and sealwort.The Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition include Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide, the content of total starches is higher than 50% in the Dendrobium officinale polysaccharide, for the content of total starches higher than 50%, the mass ratio of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide is 4 ︰ 1 in Siberian solomonseal rhizome polysaccharide.1) Dendrobium officinale polysaccharide is prepared；2) Siberian solomonseal rhizome polysaccharide is prepared；3) the Siberian solomonseal rhizome polysaccharide combination that the Dendrobium officinale polysaccharide and step 2) obtained step 1) is mentioned, obtains Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition.Pharmaceutically acceptable dosage form can be used in the Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition.The Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition have the effects that Immune-enhancing effect, alleviate physical fatigue, therefore the Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition can be applied in preparing Immune-enhancing effect, alleviating physical fatigue and other effects drug.
Description
Technical field
The present invention relates to dendrobium candidum and sealwort, more particularly, to a kind of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition and
Its preparation method and application.
Background technology
Dendrobium candidum is the dry of orchid dendrobium candidum (Dendrobium officinale Kimura et Migo)
Dry stem is China's tradition rare Chinese medicine, is known as the good reputation of " gold in medicine " from ancient times, stem of noble dendrobium medicinal history is long, early in Qin Hanshi
Phase《Sheng Nong's herbal classic》Just there is the record of " in main wound, eliminating impediment, lower gas, tonifying five zang organs consumptive disease is thin thin, Qiang Yin, long term usage thickness stomach ",
Its nature and flavor is sweet, is slightly cold, and returns stomach, kidney channel, has nourishing Yin and clearing heat, reinforcing stomach reg fluid and other effects.
Modern pharmacology research show dendrobium candidum have enhance immune, antifatigue, anti-oxidant, hypoglycemic, blood pressure lowering,
Anti-liver injury, antitumor and other effects, main component have alkaloids, polysaccharide, sesquiterpenoids, phenanthrenequione class, bibenzyl, Fluorenone
The a variety of active ingredients such as class, steroid, phenols and volatile oil, wherein, polysaccharide has many biologies as its main component
Activity and function, such as it is immunological regulation, anti-oxidant, anti-aging, anticancer, antibacterial, hypoglycemic.
Sealwort is liliaceous plant P. kingianum, sealwort or the dry rhizome of David's-harp, and sealwort is planted for " integration of drinking and medicinal herbs "
Object is traditional conventional Chinese medicine in China, first recorded in Shanxi generation《Mingyi Bielu》, it is mild-natured, sweet in flavor, enter spleen, kidney, lung channel, have and mend
The effect of kidney strengthening the essence, nourishing Yin and moistening dryness, main component include polysaccharide, steroid saponin, triterpene, alkaloid, lignanoid, flavones, plant
Object sterol and volatile oil etc., wherein Siberian solomonseal rhizome polysaccharide are the principle active component of sealwort water extract and sealwort primary bioactivity
Ingredient, modern pharmacology confirm that Siberian solomonseal rhizome polysaccharide has the multiple functions such as hypoglycemic, reducing blood lipid, enhancing immune function, anti-aging.
Dendrobium candidum and sealwort are widely used on the market as health products at present, and (Wu Yueguo waits China traditional Chinese medicine and pharmacy
Periodical, 2016,34 (8)：1946-1949), but all exist and take inconvenient, bioavailability is low in human body, effect is not notable etc.
Problem.Although also there is the report for sharing the two, stringent restriction is not carried out to its quality standard, and (Wu Yueguo waits Chinese
Traditional Chinese medicine academic periodical, 2016,34 (8)：1946-1949).If the effect of thus making full use of the two ingredient, develop a kind of new
Convenient to take, effective health products be particularly important.
Dendrobium candidum is rare medicinal herbs, its market demand continues to increase in recent years, but due to its wild resource is limited and into
Long environment constantly by destruction, can not meet ever-increasing market demand, thus, improve the extraction of Dendrobium officinale polysaccharide
Rate makes full use of existing medicinal material to be particularly important.
The content of the invention
It is an object of the invention to provide a kind of Dendrobium officinale polysaccharides and Siberian solomonseal rhizome polysaccharide composition and preparation method thereof.
Another object of the present invention is to provide the purposes of the Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition.
The Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition include Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide, the iron sheet stone
The content of total starches is higher than 50% in dry measure used in former times polysaccharide, and the content of total starches is higher than 50% in Siberian solomonseal rhizome polysaccharide, Dendrobium officinale polysaccharide and Huang
The mass ratio of smart polysaccharide is 4 ︰ 1.
The preparation method of the Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition comprises the following steps：
1) Dendrobium officinale polysaccharide is prepared；
In step 1), the specific method for preparing Dendrobium officinale polysaccharide can be：
Dendrobium candidum medicinal material is taken, crushes, soaks, heating decocts, filtering, and extracting solution concentration, concentrate is gone through alcohol precipitation
Except supernatant, precipitation is dry to get Dendrobium officinale polysaccharide；The specific method is preferably：It will clean, dry dendrobium candidum medicine
After timber-used pulverizer crushes, 60~100 mesh sieves are crossed, 15~40 times of volumes of deionized water is added in and impregnates, be warming up to 60~100 DEG C and carry
It takes 1~3 time, 1.5~3h, centrifugal filtration, extracting solution vacuum concentration, add in 4 times of 95% ethyl alcohol of volume dissolvings every time, and standing makes it
Precipitation centrifuges removal supernatant, precipitates drying, obtain Dendrobium officinale polysaccharide.
2) Siberian solomonseal rhizome polysaccharide is prepared；
In step 2), the specific method for preparing Siberian solomonseal rhizome polysaccharide can be：
Sealwort medicinal material is taken, crushes, soaks, heating decocts, filtering, and extracting solution concentration, concentrate is through alcohol precipitation, in removal
Clear liquid precipitates drying, obtains Siberian solomonseal rhizome polysaccharide；The specific method is preferably：It will clean, dry sealwort medicinal material is crushed with pulverizer
Afterwards, 60~100 mesh sieves are crossed, 15~40 times of volumes of deionized water is added in and impregnates, 60~100 DEG C is warming up to and extracts 1~3 time, every time
1.5~3h, centrifugal filtration, extracting solution are concentrated in vacuo, and add in 4 times of 95% ethyl alcohol of volume dissolvings, and standing makes its precipitation, centrifuges
Supernatant is removed, drying is precipitated, obtains Siberian solomonseal rhizome polysaccharide.
3) the Siberian solomonseal rhizome polysaccharide combination that the Dendrobium officinale polysaccharide and step 2) obtained step 1) is mentioned, obtains Dendrobium officinale polysaccharide
With Siberian solomonseal rhizome polysaccharide composition.
In step 3), in the Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition, Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide
Mass ratio can be 4 ︰ 1.
Pharmaceutically acceptable dosage form can be used in the Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition, and the dosage form can adopt
With capsule etc..
The Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition have the effects that Immune-enhancing effect, alleviate physical fatigue, therefore
The Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition can answer in preparing Immune-enhancing effect, alleviating physical fatigue and other effects drug
With.
The present invention is found through experiments that, Dendrobium officinale polysaccharide and two medicine compatibility of Siberian solomonseal rhizome polysaccharide can mutual tonifying for the deficiency, pass through preparation
Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide, and it is mixed with certain proportion, by the synergistic effect between each raw material, there is more preferable increase
The effect of strong immunity, while also have that convenient to take, absorption of human body is good, bioavailability is high, effect is more notable, it disclosure satisfy that
The demand of numerous personages has very big market potential.In addition, principle is kept with reference to energy consumption saving in practice and Product Activity,
The present invention is simple process, suitable for the extraction process of the polysaccharide of industrialized production.
Specific embodiment
Embodiment 1：The preparation of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition
The preparation of Dendrobium officinale polysaccharide：After the dendrobium candidum medicinal material will clean, dried is crushed with pulverizer, 60 mesh sieves are crossed,
It adding in 15 times of volumes of deionized water to impregnate, is warming up to 60 DEG C and extracts 1 time, each 1.5h, centrifugal filtration, extracting solution is concentrated in vacuo,
4 times of 95% ethyl alcohol of volume dissolvings are added in, standing makes its precipitates overnight, and supernatant is removed in centrifugation, precipitates drying, obtains iron sheet
Dendrobium polysaccharide.Through sulfuric acid-phynol method detection, using glucose as reference substance, total starches content is 61%.
The preparation of Siberian solomonseal rhizome polysaccharide：After the sealwort medicinal material will clean, dried is crushed with pulverizer, 60 mesh sieves are crossed, add in 15 times
Volumes of deionized water is impregnated, and is warming up to 60 DEG C and is extracted 1 time, each 1.5h, and centrifugal filtration, extracting solution is concentrated in vacuo, and adds in 4 times of bodies
Product 95% ethyl alcohol dissolving, standing make its precipitates overnight, and supernatant is removed in centrifugation, precipitates drying, obtains Dendrobium officinale polysaccharide.
Through sulfuric acid-phynol method detection, using glucose as reference substance, total starches content is 56%.
The preparation of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition：Above-mentioned Dendrobium officinale polysaccharide is with Siberian solomonseal rhizome polysaccharide with 4 ︰'s 1
Mass ratio mixing to get.
Embodiment 2：The preparation of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition
The preparation of Dendrobium officinale polysaccharide：After the dendrobium candidum medicinal material will clean, dried is crushed with pulverizer, 80 mesh sieves are crossed,
It adding in 30 times of volumes of deionized water to impregnate, is warming up to 80 DEG C and extracts 2 times, each 2.5h, centrifugal filtration, extracting solution is concentrated in vacuo,
4 times of 95% ethyl alcohol of volume dissolvings are added in, standing makes its precipitates overnight, and supernatant is removed in centrifugation, precipitates drying, obtains iron sheet
Dendrobium polysaccharide.Through sulfuric acid-phynol method detection, using glucose as reference substance, total starches content is 70%.
The preparation of Siberian solomonseal rhizome polysaccharide：After the sealwort medicinal material will clean, dried is crushed with pulverizer, 80 mesh sieves are crossed, add in 30 times
Volumes of deionized water is impregnated, and is warming up to 80 DEG C and is extracted 2 times, each 2.5h, and centrifugal filtration, extracting solution is concentrated in vacuo, and adds in 4 times of bodies
Product 95% ethyl alcohol dissolving, standing make its precipitates overnight, and supernatant is removed in centrifugation, precipitates drying, obtains Dendrobium officinale polysaccharide.
Through sulfuric acid-phynol method detection, using glucose as reference substance, total starches content is 63%.
The preparation of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition：Above-mentioned Dendrobium officinale polysaccharide is with Siberian solomonseal rhizome polysaccharide with 4 ︰'s 1
Mass ratio mixing to get.
Embodiment 3：The preparation of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition
The preparation of Dendrobium officinale polysaccharide：After the dendrobium candidum medicinal material will clean, dried is crushed with pulverizer, 100 mesh sieves are crossed,
It adds in 40 times of volumes of deionized water to impregnate, is warming up to 100 DEG C and extracts 3 times, each 3h, centrifugal filtration, extracting solution is concentrated in vacuo, and is added
Enter 4 times of 95% ethyl alcohol of volume dissolvings, standing makes its precipitates overnight, and supernatant is removed in centrifugation, precipitates drying, obtains iron sheet stone
Dry measure used in former times polysaccharide.Through sulfuric acid-phynol method detection, using glucose as reference substance, total starches content is 61%.
The preparation of Siberian solomonseal rhizome polysaccharide：After the sealwort cleaned, dried medicinal material is crushed with pulverizer, 100 mesh sieves are crossed, add in 40
Times volumes of deionized water is impregnated, and is warming up to 100 DEG C and is extracted 3 times, each 3h, and centrifugal filtration, extracting solution is concentrated in vacuo, and adds in 4 times
95% ethyl alcohol of volume dissolves, and standing makes its precipitates overnight, and supernatant is removed in centrifugation, precipitates drying, it is more to obtain dendrobium candidum
Sugar.Through sulfuric acid-phynol method detection, using glucose as reference substance, total starches content is 58%.
The preparation of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition：Above-mentioned Dendrobium officinale polysaccharide is with Siberian solomonseal rhizome polysaccharide with 4 ︰'s 1
Mass ratio mixing to get.
Embodiment 4：The preparation of dendrobium candidum sealwort capsule
Dendrobium officinale polysaccharide made from embodiment 2 and Siberian solomonseal rhizome polysaccharide composition 500g, microcrystalline cellulose 500g are mixed equal
It is even, magnesium stearate 30g is added, is crushed after mixing, crosses 80 mesh sieves, it is dry at 40 DEG C with 80% alcohol granulation, cross 10
Number sieve, whole grain, it is filling up to dendrobium candidum sealwort capsule finally to carry out capsule, and 1000 soft capsules (100mg/) are made.
Embodiment 5：The preparation of dendrobium candidum sealwort soft capsule
200g hydrogenated palm oils are weighed, are added in the medicinal soya-bean oil of 1000g, heat mixing, soft capsule matrix is made, it will be real
It applies Dendrobium officinale polysaccharide made from example 2 and Siberian solomonseal rhizome polysaccharide composition 500g is added in matrix, colloidal grinding, be made in soft capsule
It is tolerant.In mass ratio, using encapsulating machine pelleting, 1000 soft capsules are made in Ming Jiao ︰ Gan You ︰ water (1 ︰, 0.3 ︰ 1) glue
(50mg/).
Comparative example 1：The oral influence of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition to mouse immune organ
Mouse 50, using gastric infusion, research 2 gained pharmaceutical composition of embodiment is to the shadow of immune function of mice
It rings.
50 mouse are divided into 5 groups, be respectively high (3g/kg), in (1g/kg), low (0.5g/kg) dosage group, sun
Property control group (2.5mg/kg polyactins) and blank group (edible vegetable oil of capacity identical with positive controls), each experimental group
Equal gastric infusion, successive administration 7d, in addition to blank group, with the 2nd, 4,6 day injection cyclophosphamide (60mg/kg) cause mouse after administration
After last dose 1h, mouse cervical dislocation is put to death, thymus gland and spleen is stripped, weighs respectively, be calculated as follows for immunosupress
Organ index：
Table 1
The influence of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition to immunosuppressed mice Immune Organs Index is shown in Table 1, by
Table 1 is as it can be seen that with blank control group ratio, the high, medium and low dosage of composition can increase organ index, in dosage correlation, and connect
The trend of nearly positive controls, it was demonstrated that it has the ability that can promote immune organ thymus gland and Development of The Spleen.
Claims (10)
1. a kind of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that including Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide,
The content of total starches is higher than 50% in the Dendrobium officinale polysaccharide, and the content of total starches is higher than 50% in Siberian solomonseal rhizome polysaccharide, iron sheet stone
The mass ratio of dry measure used in former times polysaccharide and Siberian solomonseal rhizome polysaccharide is 4 ︰ 1.
2. the preparation method of Dendrobium officinale polysaccharide as described in claim 1 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that including with
Lower step：
1) Dendrobium officinale polysaccharide is prepared；
2) Siberian solomonseal rhizome polysaccharide is prepared；
3) the Siberian solomonseal rhizome polysaccharide combination that the Dendrobium officinale polysaccharide and step 2) obtained step 1) is mentioned, obtains Dendrobium officinale polysaccharide and Huang
Smart polysaccharide composition.
3. the preparation method of Dendrobium officinale polysaccharide as claimed in claim 2 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that in step
1) in, it is described prepare Dendrobium officinale polysaccharide specific method be：
Dendrobium candidum medicinal material is taken, crushes, soaks, heating decocts, filtering, and extracting solution concentration, concentrate is through alcohol precipitation, in removal
Clear liquid, precipitation are dry to get Dendrobium officinale polysaccharide.
4. the preparation method of Dendrobium officinale polysaccharide as claimed in claim 3 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that the system
It is for the specific method of Dendrobium officinale polysaccharide：After the dendrobium candidum medicinal material will clean, dried is crushed with pulverizer, 60~100 are crossed
Mesh sieve adds in 15~40 times of volumes of deionized water and impregnates, and is warming up to 60~100 DEG C and extracts 1~3 time, 1.5~3h, centrifuges every time
Filtering, extracting solution are concentrated in vacuo, and add in 4 times of 95% ethyl alcohol of volume dissolvings, and standing makes its precipitation, centrifuges removal supernatant,
Drying is precipitated, obtains Dendrobium officinale polysaccharide.
5. the preparation method of Dendrobium officinale polysaccharide as claimed in claim 2 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that in step
2) in, it is described prepare Siberian solomonseal rhizome polysaccharide specific method be：
Sealwort medicinal material is taken, crushes, soaks, heating decocts, filtering, and extracting solution concentration, concentrate removes supernatant through alcohol precipitation
Liquid precipitates drying, obtains Siberian solomonseal rhizome polysaccharide.
6. the preparation method of Dendrobium officinale polysaccharide as claimed in claim 5 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that the tool
Body method is：After the sealwort medicinal material will clean, dried is crushed with pulverizer, 60~100 mesh sieves are crossed, 15~40 times of volumes is added in and goes
Ionized water impregnates, and is warming up to 60~100 DEG C and extracts 1~3 time, 1.5~3h, centrifugal filtration, extracting solution vacuum concentration add in every time
4 times of 95% ethyl alcohol of volume dissolvings, standing make its precipitation, centrifuge removal supernatant, precipitate drying, obtain Siberian solomonseal rhizome polysaccharide.
7. the preparation method of Dendrobium officinale polysaccharide as claimed in claim 2 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that in step
3) in, in the Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition, the mass ratio of Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide is 4 ︰ 1.
8. the preparation method of Dendrobium officinale polysaccharide as described in claim 1 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that the iron
Skin dendrobium polysaccharide and Siberian solomonseal rhizome polysaccharide composition use pharmaceutically acceptable dosage form.
9. the preparation method of Dendrobium officinale polysaccharide as described in claim 1 and Siberian solomonseal rhizome polysaccharide composition, it is characterised in that described dose
Type uses capsule.
10. Dendrobium officinale polysaccharide and Siberian solomonseal rhizome polysaccharide composition are applied in preparing Immune-enhancing effect, alleviating physical fatigue effect drug.
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| CN110637902A (en) * | 2019-07-22 | 2020-01-03 | 湖南植歌茶业有限公司 | Black tea capable of strengthening vitality and nourishing qi and preparation method thereof |
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