CN1456210A - Products for promoting human lead discharge and preparing method thereof - Google Patents
Products for promoting human lead discharge and preparing method thereof Download PDFInfo
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- CN1456210A CN1456210A CN 03118470 CN03118470A CN1456210A CN 1456210 A CN1456210 A CN 1456210A CN 03118470 CN03118470 CN 03118470 CN 03118470 A CN03118470 A CN 03118470A CN 1456210 A CN1456210 A CN 1456210A
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Abstract
A product in the form of medicine or functional food for promoting the discharge of lead from human body is prepared from L-cysteine, VC, VB1, VB2, VB6, taurine, zinc gluconate, the extracts of chrysanthemum flower and wolfberry fruit, and additive. Its advantage is high effect.
Description
Technical field
The present invention relates to a kind of product that promotes that the interior lead of human body and other harmful heavy metal are discharged, specifically, the invention still further relates to the preparation method of this chewable tablet about promoting the chewable tablet of plumbous discharge in the human body.
Background technology
Plumbous (Pb) is a kind of human body non-essential element, and it is prevalent in natural atmosphere, soil, water and the food, can not decompose, and easily is absorbed by the body by digestive tract, respiratory tract.Its is put aside in each tissue of human body, and is wherein maximum with the skeleton amount of savings, accounts for and puts aside 85%～90% of lead in the body.Plumbous affinity to tissue is very strong, can cause multiple organ injury diseases such as liver, brain, with nervous system injury more so, often causes diseases such as peripheral neuritis, motion and paraesthesia.If lead enters cerebral tissue with blood flow, can damage cerebellum and brain cortex cell, disturb metabolic activity, cause nutrient substance and oxygen supply deficiency, thereby symptoms such as headache, hypomnesis, insomnia appear, also often with gastrointestinal symptoms such as inappetence, gastroenteritis, stomachache.
Plumbous particularly serious to the harm of children's health and intellectual development, the energy force rate adult that the child resists the lead poisoning evil is poor; Child's living habit etc. causes the lead ratio adult who takes in by digestive tract and respiratory tract many; The lead that the adult takes in has 94% savings in sclerotin, the child then has only 70%, all the other 30% are stayed in the blood, child's blood brain barrier is grown imperfection, and permeability is big, and blood lead is easy to see through blood brain barrier brain is produced murder by poisoning, as untimely removing, along with the growth of blood brain barrier is perfect, the lead that storage is stayed in the brain is difficult to get rid of, and may cause child's brain permanent lesion and mental retardation.
The basic principle of control children ' s lead poisoning is the environment intervention, health education and clinical treatment three combinations, the environment intervention is basic, health education is a basic means, and to being that the lead poisoning of BPb 〉=200ug/L is just considered clinical treatment more than the moderate, this is because the clinical treatment medicine mainly contains calcium disodium chelate (CaNa2EDTA) at present, sodium dimercaptosuccinate (DMSA) etc., though driving lead, medicine can reduce lead load in the body, Plumbum removing is effective, but the side effect that has renal damage and essential trace element to run off, and drive nervous lesion that plumbous medicine causes lead and reverse and have little significance, so the medicine Plumbum removing is concerning the child, remove the severe lead poisoning, the clinician does not generally adopt.
Health education is feasible, effective, the inexpensive intervening measure of control children ' s lead poisoning, and it comprises many-sided content, and the absorption of rational diet nutrient is that it is one of important measures, and it promotes the effect of Plumbum removing to be confirmed by numerous institutes.But because limitations of all sorts of conditions, most heads of a family are difficult to replenish to child or add these nutrients in the mode of reasonable mixture ratio, instant edible.
Chinese patent ZL97109256.7 discloses a kind of with the Thallus Laminariae (Thallus Eckloniae) immersion, edible aminoacids complex, be rich in ascorbic Chinese monkey monkey peach extracting solution, and to contain zinc Semen Helianthi extracting solution be the oral liquid of primary raw material, ZL98118072.8 discloses by vitamin C, vitamin B
1Organic zinc, aminoacids complex, the oral nutrient lead-expelling powdered granules of methionine, cysteine, Margarita powder compositions, CN1162408A discloses a kind of iodic salt of preventing and treating plumbous to human body harm, CN1166920A discloses a kind of milk powder without lead, and CN1181204A discloses a kind of bean milk powder for removing lead, and CN1283418A discloses a kind of with chitosan, sodium alginate, the Plumbum removing food additive that malic acid is formed.Foregoing invention, perhaps product form uses inconvenience, and perhaps nutrition is more single, and perhaps active ingredient is all unstable as tieing up C and containing sulfenyl chemistry of amino acids character, and reasons such as oxidative deformation take place in liquid preparation easily, and equal difficulty reaches satisfied effect.
Summary of the invention
The objective of the invention is from human body diet nutritional key element, to select suitable feedstock, pass through reasonable compatibility, make the acceptant product of child, with reach promote Plumbum removing, alleviation or prevention plumbous to the human body infringement, improve the purpose of symptom, it is edible to be suitable for the higher child of blood lead.Realize the effect of non-medicine Plumbum removing.
The present invention is achieved like this, prefabricated active ingredient composition I, and its composition is by weight: L-cysteine 0.5---12.5 weight portion, vitamin C 0.5---12.5 weight portion, vitamin B
10.025---0.625 weight portion, vitamin B
20.0125---0.3125 weight portion, vitamin B
60.025---0.625 weight portion, taurine 0.1---2.5 weight portion, zinc gluconate 0.4---10.00 weight portion, Flos Chrysanthemi and wolfberry fruit extract 0.06---1.5 weight portion; The active ingredient composition I is added proper auxiliary materials, make medicine or the edible functional food that to take.
Active ingredient composition I ZHONGJUHUA and wolfberry fruit extract preparation method are: Flos Chrysanthemi 0.3-7.5 weight portion, Fructus Lycii 0.3-7.5 weight portion are mixed, add 5-20 times of water logging bubble, decoct 2 times, each 0.5-2 hour, filter, merging filtrate, concentrate the back spray drying, the gained spray drying powder is Flos Chrysanthemi and wolfberry fruit extract.The addition of active ingredient composition I, by weight for medicine includes I 1-30%, it is 1-15% that functional food contains I.The form of product is acceptable fruit jelly, cookies, beverage, milk, a confection on tablet, granule, oral liquid, capsule, powder and the food of pharmaceutically using always.
For adapting to the demand of child's Plumbum removing, the present invention provides a kind of masticatory pattern tablet that promotes lead-eliminating effect that has especially, and the preparation method of this chewable tablet also is provided simultaneously.Get Fructus Lycii, Flos Chrysanthemi extract 0.06---1.5 weight portion, L-cysteine 0.5---12.5 weight portion, vitamin C 0.5---12.5 weight portion, vitamin B
10.025---0.625 weight portion, vitamin B
20.0125---0.3125 weight portion, vitamin B
60.025---0.625 weight portion, taurine 0.1---2.5 weight portion, zinc gluconate 0.4---10.00 weight portion pulverize separately; cross 100 mesh sieves; put in the blender and mixed 10-40 minute; even to color and luster; add cane sugar powder, glucose powder or mannitol powder, sorbitol powder, xylitol, hydroxyl isomaltulose powder; mixing; put pelletize in the fluidized bed pelletizer; keep atomizing pressure 0.1-0.4mpa; 20 ℃--60 ℃ of hot air dryings are to granule moisture content 0.5-4%, and 16 mesh sieve granulate add magnesium stearate; trace spice, tabletting promptly behind the mixing.
Chewable tablet with promotion lead-eliminating effect provided by the invention, reasonable compatibility by various diet nutrients, product form also is the acceptant masticatory pattern sugar-tablet of child, the human feeding trial result who carries out through Chinese disease control and prevention control centre's nutrition and food safety proves: after taking Plumbum removing chewable tablet group child test-meal the 20th day, the 30th day lead in urine output, is apparently higher than matched group, self relatively reach between test-meal group and matched group and compare, difference has significance P＜0.05, P＜0.01, the total output increase of lead in urine is greater than matched group P＜0.05.After the test-meal urine calcium, urine zinc are got rid of obviously influence of nothing, blood, urine, stool routine examination detected in normal range before and after the test-meal, illustrated that the Plumbum removing chewable tablet has obvious facilitation, and be harmless to health after taking, it is edible to be suitable for the higher child of blood lead, reaches the purpose of non-medicine Plumbum removing.
The specific embodiment
Below in conjunction with embodiment promotion lead-expelling product of the present invention is further described.
Embodiment 1: Fructus Lycii and Flos Chrysanthemi extract
Take by weighing Flos Chrysanthemi 1kg, Fructus Lycii 1kg, add 10 times of water gagings, soaked overnight, insulation was 1 hour after hot digestion boiled, add 10 times of water heated and boiled again with multilamellar filtered through gauze medicinal residues, after boiling, be incubated 1 hour, the multilamellar filtered through gauze, twice filtrate merges, and puts high speed centrifuge and isolates solid content, supernatant concentration, advance the spray dryer spray drying, the gained spray drying powder is Flos Chrysanthemi, wolfberry fruit extract.
Embodiment 2: promote Plumbum removing active ingredient compositions
Take by weighing L-cysteine 200g, vitamin C 200g, vitamin B
61g, vitamin B
11g, vitamin B
26g, taurine 50g, zinc gluconate 250g, Flos Chrysanthemi, wolfberry fruit extract 150g, pulverize separately is crossed 100 mesh sieves, mixed in the blender 30 minutes, to color and luster evenly promptly.
Embodiment 3: the Plumbum removing chewable tablet
Get example 2 composition compositions fine powder 500g; add adjuvant 4500g such as cane sugar powder, glucose powder or mannitol powder, sorbitol powder, xylitol, hydroxyl isomaltulose; put pelletize in the fluidized bed pelletizer; keep atomizing pressure 0.1-0.4mpa; 40 ℃ of hot air dryings with 16 mesh sieve granulate, add magnesium stearate to granule moisture content 1%; trace spice, tabletting promptly gets the Plumbum removing chewable tablet behind the mixing.
Embodiment 4: the Plumbum removing fruit latt
Get example 2 active ingredient mixture fine powder 200g, add milk 3800ml, slowly stir, make its dissolving, add strawberry essence or orange flavor essence, thickening agent is an amount of, and after stirring evenly, behind the high pressure homogenizer homogenizing, packing promptly.
Claims (6)
1. product that promotes the human body Plumbum removing is characterized in that:
The components by weight of (1) active ingredient composition I is: L---cysteine 0.5---12.5 weight portion, vitamin C 0.5---12.5 weight portion, vitamin B
10.025---0.625 weight portion, B supports one's family
20.0125---0.3125 weight portion, vitamin B
60.025---0.625 weight portion, taurine 0.1---2.5 weight portion, zinc gluconate 0.4---10.00 weight portion, Flos Chrysanthemi, wolfberry fruit extract 0.06---1.5 weight portion;
(2) the active ingredient composition I is added adjuvant, make medicine and the edible functional food that to take.
2. the product of promotion human body according to claim 1 Plumbum removing, it is characterized in that Flos Chrysanthemi, wolfberry fruit extract are mixed by Flos Chrysanthemi 0.3-7.5 weight portion, Fructus Lycii 0.3-7.5 weight portion, add 5-20 times of water logging bubble, decoct 2 times, each 0.5-2 hour, filter, merging filtrate concentrates the back spray drying, and the gained spray drying powder is Flos Chrysanthemi, wolfberry fruit extract.
3. the product of promotion human body according to claim 1 Plumbum removing, the content that it is characterized in that active ingredient composition I in the described product, containing the effective constituent composition I by weight medicine is 1-30%, and it is 1-15% that functional food contains the active ingredient composition I.
4. the product of promotion human body according to claim 1 Plumbum removing is characterized in that the form of described product is acceptable fruit jelly, cookies, beverage, milk, confection on tablet, granule, oral liquid, capsule, powder and the food pharmaceutically commonly used.
5. the product of promotion human body according to claim 4 Plumbum removing is characterized in that described tablet is a chewable tablet.
6. promote the product of human body Plumbum removing according to claim 1 or 5, it is characterized in that the preparation method of Plumbum removing masticatory pattern tablet is: get Fructus Lycii, Flos Chrysanthemi extract 0.06---1.5 weight portion, L-cysteine 0.5---12.5 weight portion, vitamin C 0.5---12.5 weight portion, vitamin B
10.025---0.625 weight portion, vitamin B
20.0125---0.3125 weight portion, vitamin B
60.025---0.625 weight portion, taurine 0.1---2.5 weight portion, zinc gluconate 0.4---10.00 weight portion pulverize separately are crossed 100 mesh sieves; put in the blender and mixed 10---40 minute; even to color and luster; add cane sugar powder, glucose powder, mannitol powder, sorbitol powder, xylitol, hydroxyl isomaltulose powder; mixing; put pelletize in the fluidized bed pelletizer; keep atomizing pressure 0.1-0.4mpa; 20 ℃ of-60 ℃ of hot air dryings are to granule moisture content 0.5-4%; 16 mesh sieve granulate; add magnesium stearate, micro-spice, tabletting is promptly behind the mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118470 CN1238008C (en) | 2003-01-14 | 2003-01-14 | Products for promoting human lead discharge and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03118470 CN1238008C (en) | 2003-01-14 | 2003-01-14 | Products for promoting human lead discharge and preparing method thereof |
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| CN1456210A true CN1456210A (en) | 2003-11-19 |
| CN1238008C CN1238008C (en) | 2006-01-25 |
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| CN 03118470 Expired - Lifetime CN1238008C (en) | 2003-01-14 | 2003-01-14 | Products for promoting human lead discharge and preparing method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100399918C (en) * | 2006-06-09 | 2008-07-09 | 天津商学院 | Substrate for making health-care food matrix with lead-eliminating function, and food therewith |
| CN101803740A (en) * | 2010-04-08 | 2010-08-18 | 北京爱富迪医药科技发展有限公司 | Health product having functions of promoting lead discharge and enhancing immunity and preparation method thereof |
| CN102727618A (en) * | 2012-07-06 | 2012-10-17 | 辽宁大学 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
| CN103478827A (en) * | 2013-08-01 | 2014-01-01 | 浙江大学 | Plant polyphenol lead-removing functional drink and preparation method thereof |
| CN103893381A (en) * | 2012-12-28 | 2014-07-02 | 石家庄富丽华德生物医药科技有限公司 | Composition with lead discharge function and preparation method and application thereof |
| CN104257887A (en) * | 2014-10-22 | 2015-01-07 | 汤臣倍健股份有限公司 | Composition for promoting lead excretion and application thereof |
| CN105192599A (en) * | 2015-08-14 | 2015-12-30 | 慧谷生命科技湖北有限公司 | Lead removing particles and preparation method thereof |
| CN107822009A (en) * | 2017-11-17 | 2018-03-23 | 荣成奥汛海洋生物科技有限公司 | A kind of marine organisms lead discharging matrix and Pb excluding health care product and preparation method thereof |
| CN107897758A (en) * | 2017-11-17 | 2018-04-13 | 荣成奥汛海洋生物科技有限公司 | Marine organism extract lead discharging matrix and Pb excluding health care product and preparation method thereof |
| CN108902810A (en) * | 2018-07-19 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of oral solution and preparation method thereof |
| CN109602837A (en) * | 2019-01-29 | 2019-04-12 | 哈工大机器人（山东）智能装备研究院 | A kind of capsule of nano and preparation method thereof with drive lead function |
| CN115702910A (en) * | 2021-08-10 | 2023-02-17 | 武汉远大弘元股份有限公司 | Composition of glutathione precursor, preparation method and application |
-
2003
- 2003-01-14 CN CN 03118470 patent/CN1238008C/en not_active Expired - Lifetime
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100399918C (en) * | 2006-06-09 | 2008-07-09 | 天津商学院 | Substrate for making health-care food matrix with lead-eliminating function, and food therewith |
| CN101803740A (en) * | 2010-04-08 | 2010-08-18 | 北京爱富迪医药科技发展有限公司 | Health product having functions of promoting lead discharge and enhancing immunity and preparation method thereof |
| CN102727618A (en) * | 2012-07-06 | 2012-10-17 | 辽宁大学 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
| CN102727618B (en) * | 2012-07-06 | 2014-05-21 | 辽宁大学 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
| CN103893381B (en) * | 2012-12-28 | 2017-10-13 | 北京富华安德生物医药科技开发有限公司 | Composition with lead-expelling function and its preparation method and application |
| CN103893381A (en) * | 2012-12-28 | 2014-07-02 | 石家庄富丽华德生物医药科技有限公司 | Composition with lead discharge function and preparation method and application thereof |
| CN103478827A (en) * | 2013-08-01 | 2014-01-01 | 浙江大学 | Plant polyphenol lead-removing functional drink and preparation method thereof |
| CN104257887A (en) * | 2014-10-22 | 2015-01-07 | 汤臣倍健股份有限公司 | Composition for promoting lead excretion and application thereof |
| CN105192599A (en) * | 2015-08-14 | 2015-12-30 | 慧谷生命科技湖北有限公司 | Lead removing particles and preparation method thereof |
| CN107822009A (en) * | 2017-11-17 | 2018-03-23 | 荣成奥汛海洋生物科技有限公司 | A kind of marine organisms lead discharging matrix and Pb excluding health care product and preparation method thereof |
| CN107897758A (en) * | 2017-11-17 | 2018-04-13 | 荣成奥汛海洋生物科技有限公司 | Marine organism extract lead discharging matrix and Pb excluding health care product and preparation method thereof |
| CN108902810A (en) * | 2018-07-19 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of oral solution and preparation method thereof |
| CN109602837A (en) * | 2019-01-29 | 2019-04-12 | 哈工大机器人（山东）智能装备研究院 | A kind of capsule of nano and preparation method thereof with drive lead function |
| CN115702910A (en) * | 2021-08-10 | 2023-02-17 | 武汉远大弘元股份有限公司 | Composition of glutathione precursor, preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1238008C (en) | 2006-01-25 |
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