CN111838500A - Ginseng pine needle effervescent tablet and preparation method thereof - Google Patents
Ginseng pine needle effervescent tablet and preparation method thereof Download PDFInfo
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- CN111838500A CN111838500A CN202010770799.8A CN202010770799A CN111838500A CN 111838500 A CN111838500 A CN 111838500A CN 202010770799 A CN202010770799 A CN 202010770799A CN 111838500 A CN111838500 A CN 111838500A
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- ginseng
- pine needle
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- 241000208340 Araliaceae Species 0.000 title claims abstract description 122
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title claims abstract description 122
- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 122
- 235000008434 ginseng Nutrition 0.000 title claims abstract description 122
- 235000008331 Pinus X rigitaeda Nutrition 0.000 title claims abstract description 102
- 241000018646 Pinus brutia Species 0.000 title claims abstract description 102
- 235000011613 Pinus brutia Nutrition 0.000 title claims abstract description 102
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 91
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 78
- 239000000843 powder Substances 0.000 claims abstract description 62
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- 229930003268 Vitamin C Natural products 0.000 claims abstract description 38
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- 235000019154 vitamin C Nutrition 0.000 claims abstract description 38
- 239000002253 acid Substances 0.000 claims abstract description 26
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 24
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- 239000002994 raw material Substances 0.000 claims abstract description 19
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- 239000008187 granular material Substances 0.000 claims description 66
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
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- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
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- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
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- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 2
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/68—Acidifying substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to the technical field of effervescent tablet preparation, in particular to a ginseng and pine needle effervescent tablet and a preparation method thereof. The feed comprises the following raw materials: alkali agent, sweetener, ginseng powder, pine needle powder, acid agent and vitamin C; the ginseng pine needle effervescent tablet prepared by the invention utilizes acid-base reaction to rapidly disintegrate the tablet into aqueous solution, so that the difficulty in swallowing the tablet is changed and the taste is improved in the process of taking the effervescent tablet by people, the absorption of nutrient components is enhanced in the process of enjoying drinks by people, the tedious operation of taking the effervescent tablet on time is avoided, the effervescent tablet has higher biological value and more important physiological function compared with the common ginseng product, the bioavailability of ginseng is improved, the immunocompetence of a human body can be effectively improved, the vitamin C is supplemented, no side effect is caused to the human body after long-term taking, and the sub-health state of the human body can be improved for a long time.
Description
Technical Field
The invention relates to the technical field of effervescent tablet preparation, in particular to a ginseng and pine needle effervescent tablet and a preparation method thereof.
Background
The ginseng-needle effervescent tablet is a health food which is composed of ginseng and pine needles and has the effect of enhancing the immunity of human bodies; the ginseng has various important pharmacological effects, can play roles in enhancing brain function, relieving fatigue of human body, enhancing immunity and the like, and is a very good raw material of a nutritional health-care product; the pine needles contain rich proanthocyanidins and bioflavonoids, can effectively remove free radicals in a human body, increase the elasticity of blood vessels, enable the human body to achieve the effects of resisting oxidation and aging and increase the immunity of the human body;
the ginseng pine needle products on the market are few, most of the ginseng pine needle products are buccal tablets, capsules or oral liquid and the like, and the ginseng pine needle products are not easy to absorb, have poor mouthfeel, are inconvenient to use and the like at different degrees; therefore, a health care product which is convenient to eat, safe and suitable for long-term use, effectively improves the sub-health state of a human body and meets the requirements of most consumers is needed at present;
the prior art has the following disadvantages:
1. like products in the market are tablet capsules and the like, and are not easy to take;
2. the human body does not cooperate with the pine needles.
Disclosure of Invention
The invention aims to provide a ginseng and pine needle effervescent tablet and a preparation method thereof, and aims to solve the problems in the background technology.
In order to achieve the above purpose, on one hand, the invention provides a ginseng pine needle effervescent tablet, which comprises the following raw materials: 1000 parts of alkali agent 600-containing material, 800 parts of sweetening agent 500-containing material, 10-200 parts of ginseng powder, 1-20 parts of pine needle powder, 1400 parts of acid agent 1000-containing material and 4-200 parts of vitamin C, further limits the content of each component of the ginseng tablet, optimizes the proportional relationship among the components to provide better effect and has better overall quality of the effervescent tablet.
The ginseng pine needle effervescent tablet provided by the invention is rapidly disintegrated into aqueous solution by utilizing acid-base reaction, so that the difficulty in swallowing the tablet is changed, the taste is improved, the absorption of nutrient components is enhanced in the process of enjoying drinks of people, and the complicated operation of taking the medicine on time is avoided. Compared with common ginseng products, the ginseng pine needle effervescent tablet has higher biological value and more important physiological function, and is beneficial to improving the bioavailability of the ginseng pine needle. The effervescent tablet can effectively improve the immunity of human body, supplement vitamin C, has no side effect on human body after long-term administration, and can improve the sub-health state of human body for a long time.
Ginseng is sweet and slightly bitter in taste, warm and mild in nature. It has effects of invigorating qi, relieving depletion, promoting fluid production, tranquilizing mind, and improving intelligence. Can be used for emergency treatment, cardiovascular diseases, stomach and liver diseases, and nervous diseases. The pine needles contain rich proanthocyanidins and bioflavonoids, can effectively remove free radicals in a human body, increase the elasticity of blood vessels, enable the human body to achieve the effects of resisting oxidation and aging and increase the immunity of the human body. Vitamin C, also called L-ascorbic acid, is a water-soluble vitamin that has antioxidant, immunity enhancing, cancer, heart disease, stroke preventing, tooth and gum protecting, etc. In addition, the consistent administration of vitamin C can reduce skin melanin pigmentation, thereby reducing black speck and freckle, and making skin white.
As a further improvement of the technical scheme, the alkaline agent is one selected from potassium carbonate, sodium carbonate, calcium carbonate, potassium bicarbonate, sodium bicarbonate or calcium bicarbonate, the alkaline agent is sodium carbonate, when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng effervescent tablet is higher, and the dissolved solution is clearer.
As a further improvement of the technical scheme, the sweetener is selected from one of sucralose, lactose or xylitol, the sweetener is lactose, and when the sweetener is lactose, the lactose can effectively improve the taste of the ginseng effervescent tablet.
As a further improvement of the technical scheme, the acid agent is one selected from tartaric acid, malic acid, fumaric acid or citric acid, the acid agent is citric acid, when the acid agent is citric acid, the disintegration speed of the ginseng effervescent tablet is faster, and the dissolved solution is clearer.
On the other hand, the invention provides a preparation method of ginseng pine needle effervescent tablets, which comprises the following operation steps of:
s1, respectively crushing the alkali agent, the acid agent and the vitamin C, and sieving by a sieve of 80 meshes;
s2, uniformly mixing the alkaline agent, the sweetener and part of the ginseng powder, and stirring to obtain a mixture a;
s3, performing wet granulation on the mixture a, and drying to obtain first granules;
s4, uniformly mixing the vitamin C, the acid agent and the rest part of the pine needle powder, and stirring to obtain a mixture b;
s5, performing wet granulation on the mixture b, and drying to obtain second granules;
s6, uniformly mixing the first particles and the second particles;
s7, tabletting to obtain ginseng and pine needle effervescent tablets;
the preparation method of the ginseng and pine needle effervescent tablets provided by the invention is simple in process, convenient to operate, low in cost and easy for industrial production, and the prepared ginseng effervescent tablets are uniform in components and stable in quality.
Preferably, in S3 and S5, the wetting agent used in the wet granulation of the first granule and the second granule is ethanol, the volume fraction of ethanol is 70-90%, preferably 80%, and the volume fraction of ethanol is typically, but not limited to, 70%, 75%, 80%, 85% or 90%.
Preferably, in S2 and S4, the content of the ginseng powder in the first granules is 10%, and the content of the pine needle powder in the second granules is 90%.
Preferably, in the S3 and the S5, the drying temperature is 55-60 ℃ and the drying time is 0.5-1h, and the ethanol is evaporated by controlling the drying temperature and time, so that the drug effect of each raw material is ensured, and the phenomena of caking and the like are avoided.
Preferably, the mixing and stirring time in S2 and S4 is 3-5 min.
Preferably, in the S3 and the S5, the first granules and the second granules pass through a 16-mesh sieve; adjusting the first and second granules to the same size facilitates a more uniform distribution of the ingredients of the subsequent tablet.
Preferably, in S6, the mixing time is 25-35 min.
Compared with the prior art, the invention has the beneficial effects that:
1. the ginseng pine needle effervescent tablet prepared by the invention is quickly disintegrated into aqueous solution by utilizing acid-base reaction, so that the difficulty in swallowing the tablet is changed, the taste is improved, the absorption of nutrient components is enhanced in the process of enjoying drinks of people, and the complicated operation of taking the medicine on time is avoided.
2. Compared with the common ginseng product, the ginseng and pine needle effervescent tablet prepared by the invention has higher biological value and more important physiological function, and is beneficial to improving the bioavailability of ginseng.
3. The ginseng and pine needle effervescent tablet prepared by the invention can effectively improve the immunity of a human body, can supplement vitamin C, has no side effect on the human body after being taken for a long time, and can improve the sub-health state of the human body for a long time.
Drawings
FIG. 1 is an overall flow diagram of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Embodiment 1 a ginseng and pine needle effervescent tablet and a preparation method thereof, comprising:
first, first particle preparation
Taking 600 parts of an alkaline agent, 800 parts of a sweetening agent and 10 parts of ginseng powder, wherein when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, when the sweetening agent is lactose, the taste of the ginseng and pine needle effervescent tablet can be effectively improved, the sodium carbonate is crushed and sieved by a 80-mesh sieve, then the sodium carbonate, the lactose and part of the ginseng powder are uniformly mixed, a mixture is prepared after stirring, and the stirring time is controlled to be 4 min;
and (b) adding the mixture a into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 55 ℃ independently, the drying time is 1h, evaporating the ethanol by controlling the drying temperature and time, simultaneously ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture through a 16-mesh sieve to obtain the first granules.
Preparation of the second and third granules
Taking 4 parts of vitamin C, 1400 parts of an acid agent and 1 part of pine needle powder, wherein when the acid agent is citric acid, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, the citric acid and the vitamin C are respectively crushed and sieved by a 80-mesh sieve, then the vitamin C, the citric acid and the rest part of pine needle powder are uniformly mixed, and a mixture b is prepared after stirring, wherein the stirring time is controlled to be 4 min;
and (b) adding the mixture in the step (b) into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 60 ℃ independently, the drying time is 0.5h, evaporating the ethanol by controlling the drying temperature and time, ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture by a 16-mesh sieve to obtain second granules.
Preparation of ginseng and pine needle effervescent tablets
Mixing the first granule and the second granule uniformly, stirring for 35min, and tabletting to obtain 4.0g each tablet, wherein the content of Ginseng radix powder in the first granule is 10%, and the content of folium Pini powder in the second granule is 90%.
Embodiment 2 a ginseng pine needle effervescent tablet and a preparation method thereof, including:
first, first particle preparation
Taking 1000 parts of an alkaline agent, 500 parts of a sweetening agent and 200 parts of ginseng powder, wherein when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, when the sweetening agent is lactose, the taste of the ginseng and pine needle effervescent tablet can be effectively improved, the sodium carbonate is crushed and sieved by a 80-mesh sieve, then the sodium carbonate, the lactose and part of the ginseng powder are uniformly mixed, a mixture a is prepared after stirring, and the stirring time is controlled to be 4 min;
and (b) adding the mixture a into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 55 ℃ independently, the drying time is 1h, evaporating the ethanol by controlling the drying temperature and time, simultaneously ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture through a 16-mesh sieve to obtain the first granules.
Preparation of the second and third granules
Taking 200 parts of vitamin C, 1000 parts of an acid agent and 20 parts of pine needle powder, wherein when the acid agent is citric acid, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, the citric acid and the vitamin C are respectively crushed and sieved by a 80-mesh sieve, then the vitamin C, the citric acid and the rest part of pine needle powder are uniformly mixed, and a mixture b is prepared after stirring, wherein the stirring time is controlled to be 4 min;
and (b) adding the mixture in the step (b) into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 60 ℃ independently, the drying time is 0.5h, evaporating the ethanol by controlling the drying temperature and time, ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture by a 16-mesh sieve to obtain second granules.
Preparation of ginseng and pine needle effervescent tablets
Mixing the first granule and the second granule uniformly, stirring for 35min, and tabletting to obtain 4.0g each tablet, wherein the content of Ginseng radix powder in the first granule is 10%, and the content of folium Pini powder in the second granule is 90%.
Embodiment 3 a ginseng pine needle effervescent tablet and a preparation method thereof, comprising:
first, first particle preparation
Taking 700 parts of an alkaline agent, 700 parts of a sweetening agent and 50 parts of ginseng powder, wherein when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, when the sweetening agent is lactose, the taste of the ginseng and pine needle effervescent tablet can be effectively improved, the sodium carbonate is crushed and sieved by a 80-mesh sieve, then the sodium carbonate, the lactose and part of the ginseng powder are uniformly mixed, a mixture is prepared after stirring, and the stirring time is controlled to be 4 min;
and (b) adding the mixture a into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 55 ℃ independently, the drying time is 1h, evaporating the ethanol by controlling the drying temperature and time, simultaneously ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture through a 16-mesh sieve to obtain the first granules.
Preparation of the second and third granules
Taking 50 parts of vitamin C, 1300 parts of an acid agent and 5 parts of pine needle powder, wherein when the acid agent is citric acid, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, the citric acid and the vitamin C are respectively crushed and sieved by a 80-mesh sieve, then the vitamin C, the citric acid and the rest part of pine needle powder are uniformly mixed, and a mixture b is prepared after stirring, wherein the stirring time is controlled to be 4 min;
and (b) adding the mixture in the step (b) into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 60 ℃ independently, the drying time is 0.5h, evaporating the ethanol by controlling the drying temperature and time, ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture by a 16-mesh sieve to obtain second granules.
Preparation of ginseng and pine needle effervescent tablets
Mixing the first granule and the second granule uniformly, stirring for 35min, and tabletting to obtain 4.0g each tablet, wherein the content of Ginseng radix powder in the first granule is 10%, and the content of folium Pini powder in the second granule is 90%.
Embodiment 4 a ginseng and pine needle effervescent tablet and a preparation method thereof, comprising:
first, first particle preparation
Taking 900 parts of an alkaline agent, 500 parts of a sweetening agent and 200 parts of ginseng powder, wherein when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, when the sweetening agent is lactose, the taste of the ginseng and pine needle effervescent tablet can be effectively improved, the sodium carbonate is crushed and sieved by a 80-mesh sieve, then the sodium carbonate, the lactose and part of the ginseng powder are uniformly mixed, a mixture a is prepared after stirring, and the stirring time is controlled to be 4 min;
and (b) adding the mixture a into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 55 ℃ independently, the drying time is 1h, evaporating the ethanol by controlling the drying temperature and time, simultaneously ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture through a 16-mesh sieve to obtain the first granules.
Preparation of the second and third granules
Taking 200 parts of vitamin C, 1100 parts of an acid agent and 20 parts of pine needle powder, wherein when the acid agent is citric acid, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, the citric acid and the vitamin C are respectively crushed and sieved by a 80-mesh sieve, then the vitamin C, the citric acid and the rest part of pine needle powder are uniformly mixed, and a mixture b is prepared after stirring, wherein the stirring time is controlled to be 4 min;
and (b) adding the mixture in the step (b) into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 60 ℃ independently, the drying time is 0.5h, evaporating the ethanol by controlling the drying temperature and time, ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture by a 16-mesh sieve to obtain second granules.
Preparation of ginseng and pine needle effervescent tablets
Mixing the first granule and the second granule uniformly, stirring for 35min, and tabletting to obtain 4.0g each tablet, wherein the content of Ginseng radix powder in the first granule is 10%, and the content of folium Pini powder in the second granule is 90%.
Embodiment 5 a ginseng pine needle effervescent tablet and a preparation method thereof, comprising:
first, first particle preparation
Taking 750 parts of an alkaline agent, 600 parts of a sweetening agent and 10 parts of ginseng powder, wherein when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, when the sweetening agent is lactose, the taste of the ginseng and pine needle effervescent tablet can be effectively improved, the sodium carbonate is crushed and sieved by a 80-mesh sieve, then the sodium carbonate, the lactose and part of the ginseng powder are uniformly mixed, a mixture is prepared after stirring, and the stirring time is controlled to be 4 min;
and (b) adding the mixture a into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 55 ℃ independently, the drying time is 1h, evaporating the ethanol by controlling the drying temperature and time, simultaneously ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture through a 16-mesh sieve to obtain the first granules.
Preparation of the second and third granules
Taking 100 parts of vitamin C, 1150 parts of an acid agent and 1 part of pine needle powder, wherein when the acid agent is citric acid, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, the citric acid and the vitamin C are respectively crushed and sieved by a 80-mesh sieve, then the vitamin C, the citric acid and the rest part of pine needle powder are uniformly mixed, and a mixture b is prepared after stirring, wherein the stirring time is controlled to be 4 min;
and (b) adding the mixture in the step (b) into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 60 ℃ independently, the drying time is 0.5h, evaporating the ethanol by controlling the drying temperature and time, ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture by a 16-mesh sieve to obtain second granules.
Preparation of ginseng and pine needle effervescent tablets
Mixing the first granule and the second granule uniformly, stirring for 35min, and tabletting to obtain 4.0g each tablet, wherein the content of Ginseng radix powder in the first granule is 10%, and the content of folium Pini powder in the second granule is 90%.
Embodiment 6 a ginseng pine needle effervescent tablet and a preparation method thereof, comprising:
first, first particle preparation
Taking 850 parts of an alkaline agent, 500 parts of a sweetening agent and 10 parts of ginseng powder, wherein when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, when the sweetening agent is lactose, the taste of the ginseng and pine needle effervescent tablet can be effectively improved, the sodium carbonate is crushed and sieved by a 80-mesh sieve, then the sodium carbonate, the lactose and part of the ginseng powder are uniformly mixed, a mixture is prepared after stirring, and the stirring time is controlled to be 4 min;
and (b) adding the mixture a into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 55 ℃ independently, the drying time is 1h, evaporating the ethanol by controlling the drying temperature and time, simultaneously ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture through a 16-mesh sieve to obtain the first granules.
Preparation of the second and third granules
Taking 50 parts of vitamin C, 1300 parts of an acid agent and 15 parts of pine needle powder, wherein when the acid agent is citric acid, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, the citric acid and the vitamin C are respectively crushed and sieved by a 80-mesh sieve, then the vitamin C, the citric acid and the rest part of pine needle powder are uniformly mixed, and a mixture b is prepared after stirring, wherein the stirring time is controlled to be 4 min;
and (b) adding the mixture in the step (b) into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 60 ℃ independently, the drying time is 0.5h, evaporating the ethanol by controlling the drying temperature and time, ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture by a 16-mesh sieve to obtain second granules.
Preparation of ginseng and pine needle effervescent tablets
Mixing the first granule and the second granule uniformly, stirring for 35min, and tabletting to obtain 4.0g each tablet, wherein the content of Ginseng radix powder in the first granule is 10%, and the content of folium Pini powder in the second granule is 90%.
Embodiment 7 a ginseng pine needle effervescent tablet and a preparation method thereof, comprising:
first, first particle preparation
Taking 800 parts of an alkaline agent, 600 parts of a sweetening agent and 100 parts of ginseng powder, wherein when the alkaline agent is sodium carbonate, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, when the sweetening agent is lactose, the taste of the ginseng and pine needle effervescent tablet can be effectively improved, the sodium carbonate is crushed and sieved by a 80-mesh sieve, then the sodium carbonate, the lactose and part of the ginseng powder are uniformly mixed, a mixture is prepared after stirring, and the stirring time is controlled to be 4 min;
and (b) adding the mixture a into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 55 ℃ independently, the drying time is 1h, evaporating the ethanol by controlling the drying temperature and time, simultaneously ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture through a 16-mesh sieve to obtain the first granules.
Preparation of the second and third granules
Taking 70 parts of vitamin C, 1200 parts of an acid agent and 10 parts of pine needle powder, wherein when the acid agent is citric acid, the disintegration speed of the ginseng and pine needle effervescent tablet is higher, the dissolved solution is clearer, the citric acid and the vitamin C are respectively crushed and sieved by a 80-mesh sieve, then the vitamin C, the citric acid and the rest part of pine needle powder are uniformly mixed, and a mixture b is prepared after stirring, wherein the stirring time is controlled to be 4 min;
and (b) adding the mixture in the step (b) into ethanol, performing wet granulation, wherein the volume fraction of the ethanol is 70-90%, preferably 80%, the drying temperature is 60 ℃ independently, the drying time is 0.5h, evaporating the ethanol by controlling the drying temperature and time, ensuring the drug effect of each raw material, avoiding the formation of agglomeration and other phenomena, and finally sieving the mixture by a 16-mesh sieve to obtain second granules.
Preparation of ginseng and pine needle effervescent tablets
Mixing the first granule and the second granule uniformly, stirring for 35min, and tabletting to obtain 4.0g each tablet, wherein the content of Ginseng radix powder in the first granule is 10%, and the content of folium Pini powder in the second granule is 90%.
Comparative example 1
The comparative example provides a ginseng and pine needle effervescent tablet which comprises the following components in parts by weight: 800 parts of sodium carbonate, 600 parts of lactose, 100 parts of ginseng powder and 1200 parts of citric acid;
vitamin C was absent compared to examples 1-7.
Comparative example 2
The comparative example provides a ginseng and pine needle effervescent tablet which comprises the following components in parts by weight: 800 parts of sodium carbonate, 100 parts of ginseng powder, 1200 parts of citric acid and 70 parts of vitamin C;
compared to examples 1-7, lactose is absent.
Comparative example 3
The comparative example provides a ginseng and pine needle effervescent tablet which comprises the following components in parts by weight: 800 parts of sodium carbonate, 100 parts of ginseng powder and 1200 parts of citric acid;
vitamin C and lactose were absent compared to examples 1-7.
Comparative example 4
The comparative example provides a ginseng and pine needle effervescent tablet which comprises the following components in parts by weight: 500 parts of sodium carbonate, 900 parts of lactose, 5 parts of ginseng powder, 1 part of pine needle powder, 1500 parts of citric acid and 250 parts of vitamin C;
the range was different compared to examples 1-7.
Comparative example 5
The comparative example provides a ginseng and pine needle effervescent tablet which comprises the following components in parts by weight: 1100 parts of sodium carbonate, 400 parts of lactose, 250 parts of ginseng powder, 25 parts of pine needles, 500 parts of citric acid and 2 parts of vitamin C;
the range was different compared to examples 1-7.
Comparative examples 1-5 provide effervescent tablets prepared by the same method as examples 1-7, wherein the missing material was not added directly and the other steps were not changed, and are not described herein.
Test example 1
The ginseng and pine needle effervescent tablets provided in the above examples 1 to 7 and comparative examples 1 to 5 were subjected to taste tests, a taste panel consisting of 100 persons was randomly invited to taste, invitation was performed in batches, and evaluation was performed individually, wherein in the test process, after each taste of one effervescent tablet, the effervescent tablet was rinsed with plain boiled water at intervals of several minutes, and then taste evaluation was continued, and sensory evaluation criteria are shown in table 1:
TABLE 1
The scores of the tasting panels for examples 1-7 were counted, and the average of 100 scores for each ginseng pine needle effervescent tablet was used as the final score, and the results are shown in the following table 2:
TABLE 2
The scores of the comparison ratios 1-5 were counted by a taste panel, and the average of 100 scores of each ginseng pine needle effervescent tablet was used as the final score, and the results are shown in the following table 3:
TABLE 3
As can be seen from tables 1 to 3, compared with comparative examples 1 to 5, the ginseng and pine needle effervescent tablets provided in examples 1 to 7 of the present invention have the advantages of better color, strong ginseng flavor, good tablet shape, no sticky impact, clear and transparent solution after disintegration, and better taste.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. A ginseng pine needle effervescent tablet comprises the following raw materials: 1000 parts of alkali agent 600-containing material, 800 parts of sweetening agent 500-containing material, 10-200 parts of ginseng powder, 1-20 parts of pine needle powder, 1400 parts of acid agent 1000-containing material and 4-200 parts of vitamin C.
2. The ginseng pine needle effervescent tablet of claim 1, wherein: the alkaline agent is one of potassium carbonate, sodium carbonate, calcium carbonate, potassium bicarbonate, sodium bicarbonate or calcium bicarbonate, and the alkaline agent is sodium carbonate.
3. The ginseng pine needle effervescent tablet of claim 1, wherein: the sweetener is selected from one of sucralose, lactose or xylitol, and the sweetener is lactose.
4. The ginseng pine needle effervescent tablet of claim 1, wherein: the acid agent is selected from one of tartaric acid, malic acid, fumaric acid or citric acid, and the acid agent is citric acid.
5. A preparation method of ginseng pine needle effervescent tablets, which comprises the ginseng pine needle effervescent tablets of any one of claims 1 to 4, and comprises the following operation steps:
s1, respectively crushing the alkali agent, the acid agent and the vitamin C, and sieving by a sieve of 80 meshes;
s2, uniformly mixing the alkaline agent, the sweetener and part of the ginseng powder, and stirring to obtain a mixture a;
s3, performing wet granulation on the mixture a, and drying to obtain first granules;
s4, uniformly mixing the vitamin C, the acid agent and the rest part of the pine needle powder, and stirring to obtain a mixture b;
s5, performing wet granulation on the mixture b, and drying to obtain second granules;
s6, uniformly mixing the first particles and the second particles;
s7, tabletting to obtain the ginseng and pine needle effervescent tablets.
6. The preparation method of the ginseng pine needle effervescent tablet as claimed in claim 5, wherein the effervescent tablet comprises the following components: in the S3 and S5, in the wet granulation of the first granule and the second granule, the wetting agent is ethanol, and the volume fraction of the ethanol is 70-90%, preferably 80%.
7. The preparation method of the ginseng pine needle effervescent tablet as claimed in claim 5, wherein the effervescent tablet comprises the following components: in the S2 and the S4, the content of the ginseng powder in the first granules is 10%, and the content of the pine needle powder in the second granules is 90%.
8. The preparation method of the ginseng pine needle effervescent tablet as claimed in claim 5, wherein the effervescent tablet comprises the following components: in the S3 and the S5, the drying temperature is 55-60 ℃ and the drying time is 0.5-1 h.
9. The preparation method of the ginseng pine needle effervescent tablet as claimed in claim 5, wherein the effervescent tablet comprises the following components: in the S2 and the S4, the mixing and stirring time is 3-5 min.
10. The preparation method of the ginseng pine needle effervescent tablet as claimed in claim 5, wherein the effervescent tablet comprises the following components: in the S3 and the S5, the first granules and the second granules are sieved by a 16-mesh sieve.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546081A (en) * | 2021-01-26 | 2021-03-26 | 吉林农业科技学院 | Ginseng effervescent tablet and preparation method thereof |
| CN114521621A (en) * | 2022-01-19 | 2022-05-24 | 韩德利 | Pine needle drink and preparation method thereof |
| CN115053962A (en) * | 2022-05-27 | 2022-09-16 | 白山关东药厂 | Ginseng and radix zanthoxyli powder, preparation method and application |
-
2020
- 2020-08-04 CN CN202010770799.8A patent/CN111838500A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546081A (en) * | 2021-01-26 | 2021-03-26 | 吉林农业科技学院 | Ginseng effervescent tablet and preparation method thereof |
| CN114521621A (en) * | 2022-01-19 | 2022-05-24 | 韩德利 | Pine needle drink and preparation method thereof |
| CN115053962A (en) * | 2022-05-27 | 2022-09-16 | 白山关东药厂 | Ginseng and radix zanthoxyli powder, preparation method and application |
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Application publication date: 20201030 |