CN108992480A - Honeysuckle chrysanthemum effervescent tablets and preparation method thereof - Google Patents
Honeysuckle chrysanthemum effervescent tablets and preparation method thereof Download PDFInfo
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- CN108992480A CN108992480A CN201810726913.XA CN201810726913A CN108992480A CN 108992480 A CN108992480 A CN 108992480A CN 201810726913 A CN201810726913 A CN 201810726913A CN 108992480 A CN108992480 A CN 108992480A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Abstract
The present invention relates to field of health care products, specifically, providing a kind of honeysuckle chrysanthemum effervescent tablets and preparation method thereof.The present invention provides a kind of honeysuckle chrysanthemum effervescent tablets, including honeysuckle powder, chrysanthemum powder, vitamin C, sour agent, alkaline agent, stabilizer and sweetener.Using acid-base reaction, tablet is made to be disintegrated into aqueous solution rapidly, people not only change tablet and be difficult to swallow during taking, but also improve mouthfeel, make people during enjoyment is had a drink, enhance the absorption of nutritional ingredient.It by the coordinated of honeysuckle powder and chrysanthemum powder, can not only effectively enhance immunity of organisms, remove moisture, improve skin and Weight-reducing and lipid-lowering, while convenient to take, it is in good taste, preservation is carried convenient for people.In addition, can also play good health care curative effect containing vitamin C in the honeysuckle chrysanthemum effervescent tablets, other compositions do not have any toxic side effect to human body, can take for a long time.
Description
Technical field
The present invention relates to field of health care products, in particular to a kind of honeysuckle chrysanthemum effervescent tablets and preparation method thereof.
Background technique
Modern society's people's lives rhythm is getting faster, and life stress is also increasing, and diet is unhealthy, environmental pollution
Deng all the body of people being allowed to be in the state of inferior health, fatiguability, immunity are low, internal heat is big, moisture is heavy, a variety of skin problems,
Three height and obese people increase.With the improvement of living standards, the people also increasingly start to focus on health and maintenance, honeysuckle and
Chrysanthemum has become the food materials with Chinese medicinal health-care function often taken in people's daily life, but the mode made tea is more
Cumbersome and be unsuitable for the people often to go out, mouthfeel is also to be improved；It the mode dysphagia of medication and needs to take on time.Cause
This, needs one kind convenient at present, can take for a long time safely, be effectively improved human body sub-health status, meet the overwhelming majority and disappear
The health care product of the person's of expense demand.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of honeysuckle chrysanthemum effervescent tablets, sub- to alleviate modern society's people's body
Health status, other forms health care product take inconvenience, effervescent tablet quality technical problem to be improved.
The second object of the present invention is to provide the preparation method of above-mentioned honeysuckle chrysanthemum effervescent tablets, the bubble of this method preparation
It is fast to rise piece rate of dissolution, it is in good taste.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
A kind of honeysuckle chrysanthemum effervescent tablets, include: 60-80 parts of honeysuckle powders according to parts by weight, 20-40 parts of chrysanthemum powders,
50-70 parts of vitamin Cs, 1700-1900 parts of sour agent, 900-1100 parts of alkaline agents, 200-280 parts of stabilizers, 100-300 parts of acidity agents
With 90-110 parts of sweeteners.
It further, according to parts by weight include: 63-77 parts of honeysuckle powders, 23-37 parts of chrysanthemum powders, 53-67 parts of vitamins
C, 1750-1850 parts of sour agent, 930-1070 parts of alkaline agents, 210-270 parts of stabilizers, 150-250 parts of acidity agents and 93-107 parts of sweet teas
Taste agent；
It preferably, according to parts by weight include: 65-75 parts of honeysuckle powders, 25-35 parts of chrysanthemum powders, 55-65 parts of vitamin Cs,
1770-1830 parts of sour agent, 950-1050 parts of alkaline agents, 230-260 parts of stabilizers, 170-230 parts of acidity agents and 95-105 parts of sweet tastes
Agent.
Further, the sour agent is selected from least one of tartaric acid, malic acid, fumaric acid or citric acid；
Preferably, the sour agent is citric acid；
Preferably, the acidity agent is sodium citrate.
Further, the alkaline agent is selected from potassium carbonate, sodium carbonate, calcium carbonate, saleratus, sodium bicarbonate or calcium bicarbonate
At least one of；Preferably, the alkaline agent is sodium carbonate.
Further, the stabilizer is selected from least one of maltodextrin, water soluble starch or chitosan；It is preferred that
Ground, the stabilizer are maltodextrin.
Further, the sweetener is selected from least one of Sucralose, lactose or xylitol；Preferably, described
Sweetener is lactose.
The present invention provides the preparation method of above-mentioned honeysuckle chrysanthemum effervescent tablets again, comprising the following steps: by alkaline agent, sour agent,
The mixture tabletting of sweetener, honeysuckle powder, chrysanthemum powder, vitamin C, acidity agent and stabilizer obtains the honeysuckle chrysanthemum bubble
Rise piece.
Further, the preparation method comprises the following steps:
(a) alkaline agent, acidity agent, sweetener, part honeysuckle powder and part chrysanthemum powder are uniformly mixed, by wet granulation
And it is dry, obtain the first particle；
(b) by vitamin C, the chrysanthemum powder mixing of stabilizer, sour agent, the honeysuckle powder and remainder of remainder is equal
It is even, by wet granulation and drying, obtain the second particle；
(c) the first particle and the second particle are uniformly mixed, by tabletting, obtain honeysuckle chrysanthemum effervescent tablets.
It further, further include step (s), first by alkaline agent, sour agent, acidity agent and vitamin C crush respectively, cross 80 mesh
Sieve, then alkaline agent, acidity agent, sweetener, part honeysuckle powder and part chrysanthemum powder are uniformly mixed；
Further, during the first particle and the second particle carry out wet granulation, used wetting agent is
Ethyl alcohol；
Preferably, the volume fraction of the ethyl alcohol be 70-90%, preferably 80%.
Further, the mass ratio of the honeysuckle powder in first particle and the honeysuckle powder in the second particle is 8-
10:5；The mass ratio of chrysanthemum powder in first particle and the chrysanthemum powder in the second particle is 1-3:1；
Preferably, in the step (a) and step (b), dry temperature independently is 55-60 DEG C, and drying time is
0.5-1h；
Preferably, in the step (a) and step (b), incorporation time 3-5min；
Preferably, in the step (a) and step (b), first particle and the second particle cross 16 meshes；
Preferably, in the step (c), incorporation time 25-35min.
Compared with prior art, the invention has the benefit that
The present invention provides a kind of honeysuckle chrysanthemum effervescent tablets, using acid-base reaction, tablet is made to be disintegrated into aqueous solution, people rapidly
During taking, not only changed tablet and be difficult to swallow, but also improved mouthfeel, the process for making people have a drink in enjoyment
In, enhance the absorption of nutritional ingredient.By the coordinated of honeysuckle powder and chrysanthemum powder, it can not only effectively enhance body and exempt from
Epidemic disease power removes moisture, improves skin and Weight-reducing and lipid-lowering, while convenient to take, in good taste, carries preservation convenient for people,
Avoid the need for the troublesome operation to take medicine on time.In addition, containing vitamin C in the honeysuckle chrysanthemum effervescent tablets, vitamin C can also
To play good health care curative effect, other compositions do not have any toxic side effect to human body, can take for a long time.The honeysuckle chrysanthemum
Effervescent tablet uniform component, stay in grade, and meanwhile it is at low cost.
The preparation method of above-mentioned honeysuckle chrysanthemum effervescent tablets provided by the invention, simple process is easy to operate, at low cost,
It is easy to industrialized production.The effervescent tablet uniform component that the preparation method is prepared, stability are good.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.
The present invention provides a kind of honeysuckle chrysanthemum effervescent tablets, according to parts by weight includes: 60-80 parts of honeysuckle powders, 20-40
Part chrysanthemum powder, 50-70 parts of vitamin Cs, 1700-1900 parts of sour agent, 900-1100 parts of alkaline agents, 200-280 parts of stabilizers, 100-
300 parts of acidity agents and 90-110 parts of sweeteners.
Above-mentioned honeysuckle chrysanthemum effervescent tablets make tablet be disintegrated into aqueous solution rapidly using acid-base reaction, and people are taking
In the process, it had not only changed tablet to be difficult to swallow, but also has improved mouthfeel, and made people during enjoyment is had a drink, enhance
The absorption of nutritional ingredient.By the coordinated of honeysuckle powder and chrysanthemum powder, it can not only effectively enhance immunity of organisms, dry
Gas improves skin and Weight-reducing and lipid-lowering, while convenient to take, in good taste, carries preservation convenient for people, avoids the need for
The troublesome operation to take medicine on time.In addition, containing vitamin C in the honeysuckle chrysanthemum effervescent tablets, vitamin C can also be played well
Health care curative effect, other compositions do not have any toxic side effect to human body, can take for a long time.The honeysuckle chrysanthemum effervescent tablets ingredient
It is uniform, stay in grade, and meanwhile it is at low cost.
Honeysuckle powder has clearing heat and detoxicating, fall fire gas, the effect of removing moisture, clear liver and improve vision, is suitable for heat, wind-heat in constitution
Flu, abscess of throat, injury thirst, hoarseness, the crowd of hypoimmunity.Further for oily skin, there are whelk, powder
The women population of thorn, color spot, also has some improvement, while can be with Weight-reducing and lipid-lowering.
Chrysanthemum powder, which can be used as medicine, cures the disease, and the food of long term usage or drink containing chrysanthemum can make us long-lived.Chrysanthemum powder can dispelling wind and eliminating dampness, disappear
Swollen analgesic, dispelling wind calming the liver play the role of adjuvant treatment to flu and headache.
Vitamin C is called L-AA, is a kind of water soluble vitamin, with anti-oxidant, raising immunity, prevention
Cancer, heart disease, apoplexy, take care of one's teeth with gum etc..In addition, adhering to that taking vitamin C can also make dermal melanin calm
It reduces, to reduce blackspot and freckle, makes whitening skin.
It should be noted that according to parts by weight, it is 60 parts that honeysuckle powder is typical but non-limiting, 62 parts, 64 parts, 68
Part, 70 parts, 72 parts, 74 parts, 76 parts or 80 parts；It is 20 parts that chrysanthemum powder is typical but non-limiting, 22 parts, 24 parts, 26 parts, 28
Part, 30 parts, 32 parts, 34 parts, 36 parts, 38 parts or 40 parts；It is 50 parts that vitamin C is typical but non-limiting, 52 parts, 54 parts, 56
Part, 58 parts, 60 parts, 62 parts, 64 parts, 66 parts, 68 parts or 70 parts；It is 1700 parts that sour agent is typical but non-limiting, 1720 parts,
1740 parts, 1760 parts, 1780 parts, 1800 parts, 1820 parts, 1840 parts, 1860 parts, 1880 parts or 1900 parts；Alkaline agent is typical but non-
It is restrictive be 900 parts, 920 parts, 940 parts, 960 parts, 980 parts, 1000 parts, 1020 parts, 1040 parts, 1060 parts, 1080 parts or
1100 parts；It is 200 parts that stabilizer is typical but non-limiting, 210 parts, 220 parts, 230 parts, 240 parts, 250 parts, 260 parts, 270
Part or 280 parts；It is 100 parts that acidity agent is typical but non-limiting, 120 parts, 140 parts, 160 parts, 180 parts, 200 parts, 220 parts,
240 parts, 260 parts, 280 parts or 300 parts；It is 90 parts that sweetener is typical but non-limiting, 92 parts, 94 parts, 96 parts, 98 parts, 100
Part, 102 parts, 104 parts, 106 parts, 108 parts or 110 parts.
In the present invention, one is preferably carried out in mode, which includes: 63-77 according to parts by weight
Part honeysuckle powder, 23-37 parts of chrysanthemum powders, 53-67 parts of vitamin Cs, 1750-1850 parts of sour agent, 930-1070 parts of alkaline agents, 210-
270 parts of stabilizers, 150-250 parts of acidity agents and 93-107 parts of sweeteners.
The honeysuckle chrysanthemum effervescent tablets include: further preferably according to parts by weight 65-75 parts of honeysuckle powders, 25-35
Part chrysanthemum powder, 55-65 parts of vitamin Cs, 1770-1830 parts of sour agent, 950-1050 parts of alkaline agents, 230-260 parts of stabilizers, 170-
230 parts of acidity agents and 95-105 parts of sweeteners.
The content of honeysuckle chrysanthemum effervescent tablets each component is further limited, the ratio optimized between each component is closed
System can provide preferably effect, and the overall quality of effervescent tablet is more preferable.
In the present invention, one is preferably carried out in mode, and sour agent is in tartaric acid, malic acid, fumaric acid or citric acid
At least one, sour agent are preferably citric acid.
When sour agent is citric acid, the disintegration rate of honeysuckle chrysanthemum effervescent tablets faster, also more clarify by dissolved solution.
In the present invention, one is preferably carried out in mode, and acidity agent is sodium citrate.Sodium citrate is for correcting tart flavour.
In the present invention, one is preferably carried out in mode, and alkaline agent is selected from potassium carbonate, sodium carbonate, calcium carbonate, saleratus, carbon
At least one of sour hydrogen sodium or calcium bicarbonate；Preferably, alkaline agent is sodium carbonate.
When alkaline agent is sodium carbonate, the disintegration rate of honeysuckle chrysanthemum effervescent tablets faster, also more clarify by dissolved solution.
In the present invention, one is preferably carried out in mode, and stabilizer is in maltodextrin, water soluble starch or chitosan
At least one；Preferably, stabilizer is maltodextrin.
The present invention one be preferably carried out in mode, sweetener in Sucralose, lactose or xylitol at least
It is a kind of；Preferably, sweetener is lactose.Lactose can improve the mouthfeel of honeysuckle chrysanthemum effervescent tablets.
Invention further provides a kind of preparation methods of above-mentioned honeysuckle chrysanthemum effervescent tablets, comprising the following steps: by alkaline agent,
The mixture tabletting of sour agent, sweetener, honeysuckle powder, chrysanthemum powder, vitamin C, acidity agent and stabilizer obtains the honeysuckle
Chrysanthemum effervescent tablets.
Above-mentioned preparation method simple process, it is easy to operate, it is at low cost, it is easy to industrialized production.The preparation method is prepared into
The effervescent tablet uniform component arrived, stability are good.
The present invention one be preferably carried out in mode, preparation method the following steps are included:
(a) alkaline agent, acidity agent, sweetener, part honeysuckle powder and part chrysanthemum powder are uniformly mixed, by wet granulation
And it is dry, obtain the first particle；
(b) by vitamin C, the chrysanthemum powder mixing of stabilizer, sour agent, the honeysuckle powder and remainder of remainder is equal
It is even, by wet granulation and drying, obtain the second particle；
(c) the first particle and the second particle are uniformly mixed, by tabletting, obtain honeysuckle chrysanthemum effervescent tablets.
In the present invention, one is preferably carried out in mode, and first by alkaline agent, sour agent, acidity agent and vitamin C crush respectively, mistake
80 meshes, then alkaline agent, acidity agent, sweetener, part honeysuckle powder and part chrysanthemum powder are uniformly mixed.
By alkaline agent, sour agent and vitamin C are crushed, and cross 80 meshes, uniform convenient for each material mixing, to be gold and silver
The stability of drug effect provides guarantee between each tablet of flower chrysanthemum effervescent tablets.
It should be noted that in one embodiment of the invention, first by honeysuckle powder in step (a), chrysanthemum powder and
Sweetener carries out after being mixed to get the first mixed powder, then by the first mixed powder with Jing Guo 80 meshes alkaline agent and acidity agent mix
To the second mixed powder；First by honeysuckle powder in step (b), after chrysanthemum powder and stabilizer are mixed to get third mixed powder, then by
Three mixed powders with Jing Guo 80 meshes vitamin C and acid agent be mixed to get the 4th mixed powder.Such mixing step can guarantee
It can adequately be uniformly mixed, save manpower and time between each component.
In the present invention, one is preferably carried out in mode, carries out the process of wet granulation in the first particle and the second particle
In, used wetting agent is ethyl alcohol.It should be understood that ethyl alcohol is ethyl alcohol used in food industry.
Preferably, the volume fraction of ethyl alcohol be 70-90%, preferably 80%.The volume fraction of ethyl alcohol is typical but unrestricted
Property is 70%, 75%, 80%, 85% or 90%.
In the present invention, one is preferably carried out in mode, the honeysuckle in honeysuckle powder and the second particle in the first particle
The mass ratio of powder is 8-10:5；The mass ratio of chrysanthemum powder in first particle and the chrysanthemum powder in the second particle is 1-3:1.It will be golden
Honeysuckle flower powder, chrysanthemum powder and sour agent independently reasonably distribute in two kinds of particles, can make the first particle and the second particle
Composition it is more reasonable, to guarantee that structure is more stable.The honeysuckle in honeysuckle powder and the second particle in first particle
The typical but non-limiting mass ratio of powder is 8:5,9:5 or 10:5；The chrysanthemum in chrysanthemum powder and the second particle in first particle
The mass ratio typical case of pollen is when restrictive for 1:1,2:1 or 3:1.
In the present invention, one is preferably carried out in mode, and in step (a) and step (b), dry temperature independently is
55-60 DEG C, drying time 0.5-1h.By the temperature and time that control is dry, by ethanol evaporation, while guaranteeing each raw material
Drug effect, and phenomena such as avoid the formation of agglomeration.
In the present invention, one is preferably carried out in mode, in step (a) and step (b), incorporation time 3-5min.
In the present invention, one is preferably carried out in mode, in step (a) and step (b), the first particle and the second particle mistake
16 meshes.By the first particle and the second particle be adjusted to identical size be conducive to subsequent tablet ingredient it is more uniform point
Cloth.
In the present invention, one is preferably carried out in mode, in step (c), incorporation time 25-35min.
Be preferably carried out in mode in of the invention, the preparation methods of honeysuckle chrysanthemum effervescent tablets the following steps are included:
(s) alkaline agent, sour agent, acidity agent and vitamin C are independently crushed, crosses 80 meshes；
(a) by sweetener, part honeysuckle powder and part chrysanthemum powder are mixed to get the first mixed powder, then by the first mixed powder
And alkaline agent, acidity agent mixing 3-5min obtain the second mixed powder, wet granulation after wetting agent is added in the second mixed powder, by 55-
60 DEG C of dry 0.5-1h cross 16 meshes and obtain the first particle；
(b) stabilizer, the honeysuckle powder of remainder and the chrysanthemum powder of remainder are mixed to get third mixed powder, then
By third mixed powder and vitamin C, sour agent mixing 3-5min obtains the 4th mixed powder, and wet process after wetting agent is added in the 4th mixed powder
Granulation crosses 16 meshes and obtains the second particle by 55-60 DEG C of dry 0.5-1h；
(c) the first particle and the second particle are uniformly mixed 25-35min, carry out tabletting, obtains honeysuckle chrysanthemum effervesce
Piece.
In above-mentioned preparation method, the mass ratio of the honeysuckle powder in the first particle and the honeysuckle powder in the second particle is 8-
10:5；The mass ratio of chrysanthemum powder in first particle and the chrysanthemum powder in the second particle is 1-3:1.
The technical solution provided to facilitate the understanding of the present invention, below with reference to embodiment to technical solution provided by the invention
It is further described.
Embodiment 1
The present embodiment provides a kind of honeysuckle chrysanthemum effervescent tablets, according to parts by weight include 60 parts of honeysuckle powders, 40 portions of chrysanthemums
Pollen, 50 parts of vitamin Cs, 1900 parts of citric acids, 100 parts of sodium citrates, 900 parts of sodium carbonate, 280 portions of maltodextrins and 90 parts of creams
Sugar.
Embodiment 2
The present embodiment provides a kind of honeysuckle chrysanthemum effervescent tablets, according to parts by weight include 80 parts of honeysuckle powders, 20 portions of chrysanthemums
Pollen, 70 parts of vitamin Cs, 1700 parts of citric acids, 300 parts of sodium citrates, 1100 parts of sodium carbonate, 200 portions of maltodextrins and 110 parts
Lactose.
Embodiment 3
The present embodiment provides a kind of honeysuckle chrysanthemum effervescent tablets, include according to parts by weight, 63 parts of honeysuckle powders, 37 portions of chrysanthemums
Pollen, 53 parts of vitamin Cs, 1850 parts of citric acids, 150 parts of sodium citrates, 930 parts of sodium carbonate, 270 portions of maltodextrins and 93 parts of creams
Sugar.
Embodiment 4
The present embodiment provides a kind of honeysuckle chrysanthemum effervescent tablets, include according to parts by weight, 77 parts of honeysuckle powders, 23 portions of chrysanthemums
Pollen, 67 parts of vitamin Cs, 1750 parts of citric acids, 250 parts of sodium citrates, 1070 parts of sodium carbonate, 210 portions of maltodextrins and 107 parts
Lactose.
Embodiment 5
The present embodiment provides a kind of honeysuckle chrysanthemum effervescent tablets, include according to parts by weight, 65 parts of honeysuckle powders, 35 portions of chrysanthemums
Pollen, 55 parts of vitamin Cs, 1830 parts of citric acids, 170 parts of sodium citrates, 950 parts of sodium carbonate, 260 portions of maltodextrins and 95 parts of creams
Sugar.
Embodiment 6
The present embodiment provides a kind of honeysuckle chrysanthemum effervescent tablets, include according to parts by weight, 75 parts of honeysuckle powders, 25 portions of chrysanthemums
Pollen, 65 parts of vitamin Cs, 1770 parts of citric acids, 230 parts of sodium citrates, 1050 parts of sodium carbonate, 230 portions of maltodextrins and 105 parts
Lactose.
Embodiment 7
The present embodiment provides a kind of honeysuckle chrysanthemum effervescent tablets, include according to parts by weight, 70 parts of honeysuckle powders, 30 portions of chrysanthemums
Pollen, 60 parts of vitamin Cs, 1800 parts of citric acids, 200 parts of sodium citrates, 1000 parts of sodium carbonate, 240 portions of maltodextrins and 100 parts
Lactose.
The preparation method for the honeysuckle chrysanthemum effervescent tablets that embodiment 1-7 is provided, follows the steps below:
(s) sodium carbonate, sodium citrate, vitamin C and citric acid are crushed respectively, and crosses 80 meshes；
(a) lactose, part honeysuckle powder and part chrysanthemum powder are uniformly mixed and obtain the first mixed powder, to the first mixed powder
80% ethyl alcohol is added in middle addition calcium carbonate and sodium citrate mixing 4min, 16 meshes is crossed after granulation, obtained wet granular is at 55 DEG C
Under the conditions of dry 1h, obtained dry particl crosses 16 meshes and obtains the first particle；
(b) maltodextrin, remainder honeysuckle powder and remainder chrysanthemum powder are uniformly mixed and obtain third mixed powder,
Vitamin C and citric acid mixing 4min are added into third mixed powder, 80% ethyl alcohol is added, 16 meshes are crossed after granulation, are obtained
Wet granular dry 0.5h, obtained dry particl under the conditions of 60 DEG C cross 16 meshes and obtain the second particle；
(c) by the first particle and the second particle mixing 30min, tabletting obtains honeysuckle chrysanthemum effervescent tablets.
Wherein, the mass ratio of step (a) and honeysuckle in step (b) is 9:5；The matter of chrysanthemum in step (a) and step (b)
Amount is than being 2:1.
Comparative example 1
This comparative example provides a kind of honeysuckle chrysanthemum effervescent tablets, according to parts by weight includes 55 parts of honeysuckle powders, 55 portions of chrysanthemums
Pollen, 48 parts of vitamin Cs, 2000 parts of citric acids, 50 parts of sodium citrates, 1300 parts of sodium carbonate, 1000 parts of sodium carbonate, 150 portions of wheats
Bud dextrin and 150 parts of lactose.
Comparative example 2
This comparative example provides a kind of honeysuckle effervescent tablet, according to parts by weight includes 70 parts of honeysuckle powders, 60 parts of vitamins
C, 1800 parts of citric acids, 200 parts of sodium citrates, 1000 parts of sodium carbonate, 240 portions of maltodextrins and 100 parts of lactose.
Compared with Example 7, lack chrysanthemum powder.
Comparative example 3
This comparative example provides a kind of chrysanthemum effervescent tablets, according to parts by weight include 30 parts of chrysanthemum powders, 60 parts of vitamin Cs,
1800 parts of citric acids, 200 parts of sodium citrates, 1000 parts of sodium carbonate, 240 portions of maltodextrins and 100 parts of lactose.
Compared with Example 7, lack honeysuckle powder.
Comparative example 4
This comparative example provides a kind of honeysuckle chrysanthemum effervescent tablets, according to parts by weight includes 70 parts of honeysuckle powders, 30 portions of chrysanthemums
Pollen, 1800 parts of citric acids, 200 parts of sodium citrates, 1000 parts of sodium carbonate, 240 portions of maltodextrins and 100 parts of lactose.
Compared with Example 7, lack vitamin C.
Comparative example 5
This comparative example provides a kind of honeysuckle chrysanthemum effervescent tablets, according to parts by weight includes 70 parts of honeysuckle powders, 30 portions of chrysanthemums
Pollen, 60 parts of vitamin Cs, 1800 parts of citric acids, 1000 parts of sodium carbonate and 240 portions of maltodextrins.
Compared with Example 7, lack lactose and sodium citrate.
The preparation method for the effervescent tablet that comparative example 1-5 is provided is with embodiment 7, and details are not described herein.
Test example 1
The effervescent tablet that above-described embodiment 1-7 and comparative example 1-5 are provided carries out correlated performance detection, the result is as follows:
As can be seen from the above table, the honeysuckle chrysanthemum effervescent tablets piece type that 1-7 of the embodiment of the present invention is provided is good, without glutinous punching, collapses
Rapidly, the used time is short, solution clear after disintegration, and weight and mouthfeel are basically unchanged in 3 months, and stability is good for solution.
Further analysis shows that piece shape is more preferable for the effervescent tablet in embodiment 1-7 is compared to comparative example 1-5, without glutinous
Punching, disintegration time is shorter, and solution whole clear allows consumer to feel more relieved.Illustrate honeysuckle chrysanthemum provided by the invention
Effervescent tablet component and more reasonable, each raw material coordinated of proportion, effervescent tablet quality obtained are more preferable.
In addition, the effervescent tablet to embodiment 1-7 and comparative example 1-5 has carried out microbioassay, microorganism is not found
In the presence of.
Test example 2
In order to verify the effect for the effervescent tablet that embodiment 1-7 and comparative example 1-5 is provided, having randomly selected has abscess of throat
With 600 people of anemopyretic cold patient of headache, it is divided into 12 groups, every group of 50 people are taken respectively in embodiment 1-7 and comparative example 1-5
Effervescent tablet, daily everyone three times, 3 tablets once, and every sheet weight 3.5g observes curative effect after a week, the result is as follows:
In the curative effect statistics of the present embodiment, cure as anemopyretic cold healing；It is effective to be cured substantially for anemopyretic cold；Effectively
Have for abscess of throat and headache and slightly improves；It is substantially unchanged for anemopyretic cold in vain.
It can be seen that total effective rate in embodiment 1-7 from result above and be all higher than comparative example 1-5, say that the name present invention mentions
The honeysuckle effervescent tablet component and proportion of confession rationally, can effectively improve anemopyretic cold.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of honeysuckle chrysanthemum effervescent tablets, which is characterized in that according to parts by weight include: 60-80 parts of honeysuckle powders, 20-40
Part chrysanthemum powder, 50-70 parts of vitamin Cs, 1700-1900 parts of sour agent, 900-1100 parts of alkaline agents, 200-280 parts of stabilizers, 100-
300 parts of acidity agents and 90-110 parts of sweeteners.
2. honeysuckle chrysanthemum effervescent tablets according to claim 1, which is characterized in that according to parts by weight include: 63-77 parts
Honeysuckle powder, 23-37 parts of chrysanthemum powders, 53-67 parts of vitamin Cs, 1750-1850 parts of sour agent, 930-1070 parts of alkaline agents, 210-270
Part stabilizer, 150-250 parts of acidity agents and 93-107 parts of sweeteners；
It preferably, according to parts by weight include: 65-75 parts of honeysuckle powders, 25-35 parts of chrysanthemum powders, 55-65 parts of vitamin Cs,
1770-1830 parts of sour agent, 950-1050 parts of alkaline agents, 230-260 parts of stabilizers, 170-230 parts of acidity agents and 95-105 parts of sweet tastes
Agent.
3. honeysuckle chrysanthemum effervescent tablets according to claim 1 or 2, which is characterized in that the acid agent is selected from tartaric acid, apple
At least one of tartaric acid, fumaric acid or citric acid；
Preferably, the sour agent is citric acid；
Preferably, the acidity agent is sodium citrate.
4. honeysuckle chrysanthemum effervescent tablets according to claim 1 or 2, which is characterized in that the alkaline agent is selected from potassium carbonate, carbon
At least one of sour sodium, calcium carbonate, saleratus, sodium bicarbonate or calcium bicarbonate；Preferably, the alkaline agent is sodium carbonate.
5. honeysuckle chrysanthemum effervescent tablets according to claim 1 or 2, which is characterized in that the stabilizer is pasted selected from malt
At least one of essence, water soluble starch or chitosan；Preferably, the stabilizer is maltodextrin.
6. honeysuckle chrysanthemum effervescent tablets according to claim 1 or 2, which is characterized in that the sweetener is selected from trichlorine sugarcane
At least one of sugar, lactose or xylitol；Preferably, the sweetener is lactose.
7. the preparation method of honeysuckle chrysanthemum effervescent tablets described in any one of claims 1-6, which is characterized in that including following step
It is rapid: the mixture tabletting of alkaline agent, sour agent, sweetener, honeysuckle powder, chrysanthemum powder, vitamin C, acidity agent and stabilizer is obtained
The honeysuckle chrysanthemum effervescent tablets.
8. preparation method according to claim 7, which comprises the following steps:
(a) alkaline agent, acidity agent, sweetener, part honeysuckle powder and part chrysanthemum powder are uniformly mixed, by wet granulation and are done
It is dry, obtain the first particle；
(b) vitamin C, stabilizer, sour agent, the honeysuckle powder of remainder and the chrysanthemum powder of remainder are uniformly mixed, warp
Wet granulation and drying are crossed, the second particle is obtained；
(c) the first particle and the second particle are uniformly mixed, by tabletting, obtain honeysuckle chrysanthemum effervescent tablets.
9. preparation method according to claim 8, which is characterized in that first by alkaline agent, sour agent, acidity agent and vitamin C point
It does not crush, crosses 80 meshes, then alkaline agent, acidity agent, sweetener, part honeysuckle powder and part chrysanthemum powder are uniformly mixed；
Preferably, during the first particle and the second particle carry out wet granulation, used wetting agent is ethyl alcohol；
Preferably, the volume fraction of the ethyl alcohol be 70-90%, preferably 80%.
10. preparation method according to claim 8 or claim 9, which is characterized in that the honeysuckle powder in first particle and
The mass ratio of honeysuckle powder in two particles is 8-10:5；The chrysanthemum powder in chrysanthemum powder and the second particle in first particle
Mass ratio be 1-3:1；
Preferably, in the step (a) and step (b), dry temperature independently is 55-60 DEG C, drying time 0.5-
1h；
Preferably, in the step (a) and step (b), incorporation time 3-5min；
Preferably, in the step (a) and step (b), first particle and the second particle cross 16 meshes；
Preferably, in the step (c), incorporation time 25-35min.
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| CN201810726913.XA CN108992480A (en) | 2018-07-02 | 2018-07-02 | Honeysuckle chrysanthemum effervescent tablets and preparation method thereof |
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| CN111528387A (en) * | 2020-05-19 | 2020-08-14 | 天津尖峰弗兰德医药科技发展有限公司 | Plant-based composition for enhancing immunity and protecting respiratory system and preparation thereof |
| CN115251273A (en) * | 2022-08-11 | 2022-11-01 | 亳州学院 | Mandarin duck rattan effervescent tablet and preparation method thereof |
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Address after: No.1302, No.7, Dongqing street, high tech Industrial Development Zone, Zhengzhou City, Henan Province 450001 Applicant after: Bokai Pharmaceutical Co.,Ltd. Address before: 450000 No. 5 Acacia Street, hi tech Development Zone, Henan, Zhengzhou Applicant before: ZHENGZHOU BIOCARO PHARMACEUTICAL HEALTH-CARE PRODUCTS CO.,LTD. |
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Application publication date: 20181214 |