CN110313597A - One kind is instant to be exempted to rush throat soothing particle and preparation method thereof - Google Patents

One kind is instant to be exempted to rush throat soothing particle and preparation method thereof Download PDF

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Publication number
CN110313597A
CN110313597A CN201811347209.XA CN201811347209A CN110313597A CN 110313597 A CN110313597 A CN 110313597A CN 201811347209 A CN201811347209 A CN 201811347209A CN 110313597 A CN110313597 A CN 110313597A
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China
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parts
particle
instant
starch
powder
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CN201811347209.XA
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Inventor
贤欢
罗艳萍
罗汝锋
冯婉怡
蓝泽基
罗进
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Guangdong Yifang Pharmaceutical Co Ltd
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Guangdong Yifang Pharmaceutical Co Ltd
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Priority to CN201811347209.XA priority Critical patent/CN110313597A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/37—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/25—Agglomeration or granulation by extrusion or by pressing, e.g. through small holes, through sieves or between surfaces
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/12—Apparatus or processes for applying powders or particles to foodstuffs, e.g. for breading; Such apparatus combined with means for pre-moistening or battering
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/15—Apparatus or processes for coating with liquid or semi-liquid products
    • A23P20/18—Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/42—Cucurbitaceae (Cucumber family)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract

The invention discloses it is a kind of it is instant exempt to rush throat soothing particle and preparation method thereof, be made of the raw material of following weight parts: 20-50 parts of Siraitia grosvenorii, 20-50 parts of peppermint, 20-50 parts of campanulaceae, 20-50 parts of Radix Glycyrrhizae, 10-30 parts of semen armeniacae amarae, 10-100 parts of sugar alcohol, instant Fruit powder 20-40 parts, 30-100 parts of starch, 3-10 parts of disintegrating agent, 0.05-0.3 parts of sweetener, 0.1-0.8 parts of citric acid, 0.05-0.4 parts of menthol.It is of the invention instant to exempt to rush throat soothing particle and realize to exempt to brew, mouth containing takes fater disintegration, and particle thawing can produce strong and comfortable refrigerant sense, ice is refreshing persistently, and throat discomfort sense can be effectively relieved, and it is in good taste, the smell of fruits is very sweet, unique flavor, has effects that preferably to purify oral cavity, throat of releiving, it is a kind of pharynx-clearing throat-benefiting, healthy ready-to-eat food both with effect and mouthfeel.

Description

One kind is instant to be exempted to rush throat soothing particle and preparation method thereof
Technical field
The invention belongs to food processing technology fields, and in particular to one kind is instant to be exempted to rush throat soothing particle and preparation method thereof.
Background technique
With the development of modern industry, air quality also following the problems such as atmosphere pollution, that human breathing is relied on Also it is affected, easily leads to the inferior health problems such as people's respiratory tract discomfort.Have some protection throats on the market at present, releive The products such as granule, the tablet of respiratory tract discomfort, such as: patent 201610170739.6 disclose it is a kind of by Siraitia grosvenorii, Rabdosia rubescens, Double-layer tablets of the extracts such as lavender through obtained by tabletting, having effects that throat-clearing lung-moistening He removing removing abnormal flavor in oral cavity；Patent 2015106011.96.4 a kind of instant solid tea and preparation method thereof with pharynx-clearing throat-benefiting is disclosed, by the sterculia seed, ingeniously The tinkling of pieces of jade spends equal medicinal materials to obtain spray powder through crushing extraction, pelletizes afterwards；Patent 201010585612.3 is disclosed to be mentioned by vegetation water Object is anti-oxidant discoloration, improves the storage-stable of lozenge through throat soothing lozenge made from granulation and tabletting, technical point；Patent 201110232109.4 disclosing one kind by instant gynostemma pentaphyllum effervescent tablet preparation process, it is long to solve gynostemma pentaphylla tealeaves brewing time The problem of being not easy with carrying；Patent 201710159207.7 discloses a kind of preparation side of escitalopram oxalate oral disintegrating tablet Method, using escitalopram oxalate as main component, addition disintegrating agent, corrigent etc. are prepared using dry granulation technology.
However existing clearing effect product is mostly to need to brew the granular preparation taken with boiled water, mouthfeel is poor, portable Property it is insufficient, be not suitable for the crowds such as dysdipsia, bed patient, children；Existing tablet edible way is oral containing change, but The problem of solution rate in oral cavity is slower, easily causes choke to eat the crowds such as children, and current tablet, granule product mouthfeel are not It is good.
Summary of the invention
In order to overcome the above-mentioned deficiencies of the prior art, a kind of instant exempt to rush throat soothing the primary purpose of the present invention is that providing Grain, which, which can realize, exempts to brew, and mouth containing takes fater disintegration, can produce lasting and comfortable refrigerant sense, throat is effectively relieved not Suitable sense, has preferable throat-clearing throat-moistening effect；And it is in good taste, the smell of fruits is very sweet, unique flavor.
Another object of the present invention is to provide the above-mentioned instant preparation methods for exempting to rush throat soothing particle.
The present invention is achieved through the following technical solutions；
One kind is instant to be exempted to rush throat soothing particle, is made of the raw material of following weight parts: 20-50 parts of Siraitia grosvenorii, 20-50 parts of peppermint, and tangerine 20-50 parts of stalk, 20-50 parts of Radix Glycyrrhizae, 10-30 parts of semen armeniacae amarae, 10-100 parts of glycitols, instant Fruit powder 20-40 parts, starch 30-100 parts, 3-10 parts of disintegrating agent, 0.05-0.3 parts of sweetener, 0.1-0.8 parts of citric acid, 0.05-0.4 parts of menthol.
The technical solution further preferred as the present invention, described one kind is instant to be exempted to rush throat soothing particle, by following weight parts Raw material be made: 30 parts of Siraitia grosvenorii, 40 parts of peppermint, 40 parts of campanulaceae, 35 parts of Radix Glycyrrhizae, 20 parts of semen armeniacae amarae, 80 parts of sugar alcohol, instant fruit 30 parts of powder, 30 parts of starch, 5 parts of disintegrating agent, 0.2 part of sweetener, 0.6 part of citric acid, 0.3 part of menthol.
The pharmacological action of each raw material is reported state as follows in the present invention:
Campanulaceae: it is mild-natured, it is bitter, pungent；It is distributed in lung channel.Promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis can be used for coughing with a lot of sputum, chest distress, pharynx Pain hoarse voice, lung carbuncle pyemesis.
Radix Glycyrrhizae: mild-natured, sweet in flavor；Return heart, lung, spleen, stomach meridian.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain is adjusted With all medicines, it can be used for fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum relieves pain.
Siraitia grosvenorii: it is cool in nature, it is sweet in flavor；Return lung, large intestine channel.Clearing heat and moistening lung, relieving sore-throat open sound, can be used for lung-heat type cough, and pharyngalgia is lost Sound.
Semen armeniacae amarae: slightly warm in nature, bitter are slightly poisonous；Return lung, large intestine channel.Sending down abnormally ascending is relieving cough and asthma, and relax bowel and defecation can be used for cough It coughs asthma, the diseases such as fullness sensation in chest abundant expectoration.
Peppermint: cool in nature, acrid flavour；Return lung, Liver Channel.Dispelling wind and heat from the body, head clearing, relieving sore-throat, promoting eruption, soothing the liver promoting the circulation of qi.It can be used for Headache due to pathogenic wind-heat, hot eyes, sore throat, aphtha, the diseases such as Breast bilges frowsty.Peppermint contain ethereal oil, protein, fat, carbohydrate, The ingredients such as minerals, vitamin.Menthol ingredient in Herba Menthae Haplocalycis volatile oil has effects that sterilizing and itch-relieving, and mind can be stimulated by being applied to part Through and cause cool feeling, and inhibit pain nerve, can also releive respiratory tract, have the function of clearing cough-relieving.
The invention also discloses the above-mentioned instant preparation methods for exempting to rush throat soothing particle of one kind, include the following steps:
A) peppermint is taken, is cleaned, 50 DEG C or less low temperature dryings are ground into 40-60 mesh powder, are obtained with supercritical carbon dioxide extracting Peppermint oil, peppermint oil are saved with cleaner, spare；Campanulaceae is cleaned, and 3-5mm sheet is cut into drying；Radix Glycyrrhizae is cleaned, and drying is cut At 3-5mm sheet；Semen armeniacae amarae is cleaned, and 50 DEG C or less low temperature dryings are ground into 11-20 mesh coarse grain；Siraitia grosvenorii is cleaned, drying, It is ground into 11-20 mesh coarse grain；
B) peppermint after taking supercritical carbon dioxide extracting is added a) campanulaceae, Radix Glycyrrhizae, Siraitia grosvenorii, adds water to cook, water boiling After be added a) semen armeniacae amarae, decoct twice, for the first time plus 8-10 times is measured water, is decocted 1-3 hour, add 4-6 times and measure water for second, It decocts 1-2 hours, filtration, merging filtrate, the immersion liquid for being 1.01-1.11 to relative density is concentrated under reduced pressure at 70 DEG C, using spray Mixed extract powder is prepared in mist drying；
C) sugar alcohol is taken, 80-100 mesh is smashed it through, it is spare；Starch is taken, it is spare after crossing 80-100 mesh；Instant Fruit powder is taken, It is spare after crossing 80-100 mesh；Citric acid is taken, it is spare after crossing 80-100 mesh；Menthol is taken, 80-100 mesh is smashed it through, It is spare；
D) it takes c) part sugar alcohol and partial starch to be uniformly mixed, obtains mixed powder, it is spare；
E) peppermint oil for taking step a) to obtain, is dissolved with ethyl alcohol, obtains solutions of mint oil, spare；
F) it takes b) the mixed extract powder, c) remaining sugar alcohol, instant Fruit powder, remaining starch, citric acid and thin is added Lotus brain, disintegrating agent and sweetener, mix well, and particle is prepared with Squeezinggranulator；
G) f) particle is placed on 80 mesh screens, takes the e) solutions of mint oil, be uniformly sprayed on particle surface, after will d) The mixed powder is equably sprinkled upon particle surface, keep even particle size, surface smooth to get.
The present invention is by testing the further preferred technique of supercritical carbon dioxide extracting peppermint, the overcritical dioxy Change the condition of carbon extraction are as follows: extraction kettle 20~25MPa of pressure separates I pressure, 5~10 MPa, separates II pressure, 4~8 MPa, extraction Taking temperature is 35~45 DEG C, and I temperature of separation is 45~55 DEG C, and II temperature of separation is 30~35 DEG C, carbon dioxide flow 20- 30L/h, extraction time are 1.5-3 hours.
To keep finally obtained particle shape size uniform, surface is smooth, it is preferred that step g), in the sieve for holding particle Mixed powder described in d) is sieved by online side by the concussion of 100 mesh screens, uniformly to trickle down in particle surface, while constantly being shaken Dynamic sieve, makes particle equably adsorb mixed-powder.
In order to be better achieved technical effect of the invention, the present invention respectively to sugar alcohol, starch, disintegrating agent and sweetener into Go optimizing research, detailed process is as follows:
Test 1: the screening of sugar alcohol:
Experimental method:
Raw material proportioning: 30 parts of Siraitia grosvenorii, 40 parts of peppermint, 40 parts of campanulaceae, 35 parts of Radix Glycyrrhizae, 20 parts of semen armeniacae amarae, 30 parts of instant Fruit powder, 30 parts of potato starch, 4 parts of sodium carboxymethyl starch, 1 part of povidone, 0.15 part of steviol glycoside, 0.05 part of Sucralose, citric acid 0.6 part, 0.3 part of menthol.
According to the above-mentioned instant preparation method for exempting to rush throat soothing particle, matched with different sugar alcohols, through same preparation process system It is standby to obtain granule product, it scores respectively its mouthfeel, including particle sugariness, refrigerant sense；Measuring particle dissolves speed simultaneously Degree (the time required to entrance is completely dissolved, unit is the second), cooling perception lasts time (unit is the second), hygroscopicity (are placed in air Quality increases ratio after for 24 hours, and hereinafter referred to as quality increases ratio) etc. every index；
Sugar alcohol described in step d) is fixed as 10 portions of mannitol, and the sugar alcohol in step f) is respectively with 30-70 parts of xylitols, sorboses The addition of one or more of alcohol, antierythrite, mannitol mixture, particle sugariness, refrigerant sense, melting speed, refrigerant sense Duration, hygroscopicity result are as shown in the table:
It can be obtained by experimental data, in step f), secondly it is erythrose that D-sorbite sugariness, which is suitable for and can provide preferable refrigerant sense, Alcohol；Particle melting speed and hygroscopicity are without significant difference；Therefore it is preferred, the sugar alcohol in step f) is D-sorbite and erythrose Alcohol, mass ratio 5:2-7:0；It is further preferred that sugar alcohol is D-sorbite 50-70 parts.
In addition, sugar alcohol described in step f) is fixed as 70 parts of D-sorbites, the sugar alcohol in step d) is respectively with 10-100 parts The addition of one or more of xylitol, D-sorbite, antierythrite, mannitol mixture, it is particle sugariness, refrigerant sense, molten Change speed, cooling perception lasts time, hygroscopicity result are as shown in the table:
As seen from the experiment, the hygroscopicity of different sugar alcohols proportion, particle has significant difference, it is preferred that in step d) Glycitols be mannitol, additive amount be 10-20 parts.
Test 2: the screening of starch:
Experimental method: raw material proportioning is the same as test 1.
According to the above-mentioned instant preparation method for exempting to rush throat soothing particle, matched with different starch, through same preparation process system It is standby to obtain granule product, it scores respectively its mouthfeel, including particle sugariness, refrigerant sense；Measuring particle dissolves speed simultaneously Degree (the time required to entrance is completely dissolved, unit is the second), cooling perception lasts time (unit is the second), hygroscopicity (are placed in air Quality increases ratio after for 24 hours, and hereinafter referred to as quality increases ratio) etc. every index；
Starch described in step d) is fixed as 10 parts of potato starch, the starch in step f) respectively with 30-50 portions of soluble starches, The addition of one or more of water soluble starch, cornstarch, potato starch mixture, particle sugariness, are dissolved at refrigerant sense Speed, cooling perception lasts time, hygroscopicity result are as shown in the table:
Can be obtained by experimental data, the proportion of starch mainly affects the refrigerant sense of particle in step f), potato starch it is clear Cool feeling is best, therefore preferred, and the starch in step f) is potato starch, and 30-40 parts of additive amount.
In addition, starch described in step f) is fixed as 30 parts of potato starch, the starch in step d) is respectively with 5-20 parts The addition of one or more of soluble starch, water soluble starch, cornstarch, potato starch mixture, particle sugariness, Refrigerant sense, melting speed, cooling perception lasts time, hygroscopicity result are as shown in the table:
Can be obtained by experimental data, the starch in step d) mainly influences the melting speed and refrigerant sense of particle, potato starch and The melting speed of cornstarch is very fast, but the refrigerant degree of cornstarch is insufficient, therefore preferred, and the starch in step d) is Ma Ling Sweet potato starch, 5-10 parts of additive amount.
Test 3: the screening of disintegrating agent:
Experimental method: raw material proportioning is the same as test 1.
According to the above-mentioned instant preparation method for exempting to rush throat soothing particle, 3-10 portions of disintegrating agents are added, through same preparation process system It is standby to obtain granule product, measure particle melting speed respectively (the time required to entrance is completely dissolved, unit is the second)；
The experimental results are shown inthe following table；
It can be obtained by experimental data, it is preferred that the proportion of disintegrating agent is the mass ratio 4:1-5:0 of sodium carboxymethyl starch and povidone, The more preferably mass ratio 4:1 of sodium carboxymethyl starch and povidone.
Test 4: the screening of sweetener:
Experimental method: raw material proportioning is the same as test 1.
According to the above-mentioned instant preparation method for exempting to rush throat soothing particle, matched with different sweeteners, through same preparation process Granule product is prepared, scores respectively its mouthfeel, including taste after particle sugariness, trial test；
Experimental result: appraisal result is as shown in the table；
It can be obtained by experimental data, it is preferred that the proportion of sweetener is the mass ratio 3:1 of steviol glycoside and Sucralose.
Compared with prior art, the present invention having the following beneficial effects:
(1) present invention is prepared with the pure natural integration of drinking and medicinal herbs raw material with throat-clearing throat-moistening by the screening of auxiliary material
Particle can realize and exempt to brew, mouth containing takes fater disintegration, and disintegration time is less than 10s, the problem of not will cause choke food, small The crowds such as youngster, dysphagia are edible, and particle thawing can produce strong and comfortable refrigerant sense, and ice is refreshing persistently, can be effective Alleviate throat discomfort sense；Volatile oil is extracted by raw material of natural peppermint, is added in product, retains natural peppermint fragrance, together The refrigerant sense of Shi Zengqiang particle；Instant Fruit powder is added, in good taste, the smell of fruits is very sweet, unique flavor, has preferable purification mouth Chamber, throat effect of releiving are a kind of pharynx-clearing throat-benefiting, healthy ready-to-eat food both with effect and mouthfeel.
(2) for preparation process of the invention by optimization, peppermint raw material uses supercritical extraction method to extract volatile oil in advance, Peppermint oil is dissolved with a small amount of ethyl alcohol, is uniformly sprayed on particle surface, remains the special aroma of peppermint to the maximum extent, and is enhanced The refrigerant sense of particle；In addition, solutions of mint oil as adhesive, facilitate particle surface adsorb one layer be conducive to particle it is quick It dissolves, the sugar alcohol powder of anti-moisture absorption with refrigerant sense, effectively optimizes the mouthfeel of particle, while ensuring that particle is not easy the moisture absorption.
Specific embodiment
Further illustrate that the present invention, following embodiment are the specific embodiment party of the present invention below by specific embodiment Formula, but embodiments of the present invention are not limited by following embodiments.
Raw material of the invention derives from commercially available.
Embodiment 1:
Bulk pharmaceutical chemicals proportion:
30 parts of Siraitia grosvenorii, 40 parts of peppermint, 40 parts of campanulaceae, 35 parts of Radix Glycyrrhizae, 20 parts of semen armeniacae amarae, 30 parts of instant Fruit powder, sugar alcohol (sorb 70 parts of sugar alcohol, 10 parts of mannitol), starch (40 parts of potato starch), disintegrating agent (4 parts of sodium carboxymethyl starch, 1 part of povidone), Sweetener (0.15 part of steviol glycoside, 0.05 part of Sucralose), 0.6 part of citric acid, 0.3 part of menthol.
Its preparation process includes the following steps:
A) peppermint is taken, is cleaned, 50 DEG C or less low temperature dryings are ground into 40-60 mesh powder, are obtained with supercritical carbon dioxide extracting Peppermint oil, peppermint oil are saved with cleaner, spare；Campanulaceae is cleaned, and 3-5mm sheet is cut into drying；Radix Glycyrrhizae is cleaned, and drying is cut At 3-5mm sheet；Semen armeniacae amarae is cleaned, and 50 DEG C or less low temperature dryings are ground into 11-20 mesh coarse grain；Siraitia grosvenorii is cleaned, drying, It is ground into 11-20 mesh coarse grain；Wherein, supercritical carbon dioxide extracting condition are as follows: extraction kettle pressure 20MPa separates I pressure 8 MPa separates II pressure, 5 MPa, and extraction temperature is 40 DEG C, and I temperature of separation is 50 DEG C, and II temperature of separation is 30 DEG C, carbon dioxide Flow is 25 L/h, and extraction time is 2 hours；
B) peppermint after taking supercritical carbon dioxide extracting is added a) campanulaceae, Radix Glycyrrhizae, Siraitia grosvenorii, adds water to cook, water boiling After be added a) semen armeniacae amarae, decoct twice, for the first time plus 9 times of amount water, decoct 2 hours, second plus 5 times of amount water, decoction 1 is small When, the immersion liquid for being 1.06 to relative density is concentrated under reduced pressure at 70 DEG C, is prepared using spray drying for filtration, merging filtrate Mixed extract powder；
C) sugar alcohol, i.e. D-sorbite, mannitol are taken, 100 meshes are smashed it through, it is spare；Starch, i.e. potato starch are taken, crosses 100 It is spare after mesh；Instant Fruit powder is taken, it is spare after sieving with 100 mesh sieve；Citric acid is taken, it is spare after sieving with 100 mesh sieve；Take solid-like Menthol smashes it through 100 meshes, spare；
D) it takes the c) mannitol and 10 parts of potato starch to be uniformly mixed, obtains mixed powder, it is spare；
E) peppermint oil for taking step b) to obtain, is dissolved with ethyl alcohol, obtains solutions of mint oil, spare；
F) b) the mixed extract powder is taken, c) D-sorbite, instant Fruit powder, 30 parts of potato starch, lemons are added Lemon acid and menthol, disintegrating agent and sweetener, mix well, particle are prepared with Squeezinggranulator；
G) f) particle is placed on 80 mesh screens, takes the e) solutions of mint oil, be uniformly sprayed on particle surface, is holding Above the sieve of particle, by the mixed powder described in d), is shaken and be sieved by 100 mesh screens, uniformly to trickle down in particle surface, together When constantly shake sieve, so that particle is equably adsorbed mixed-powder, keep even particle size, surface smooth to get.
Embodiment 2:
Bulk pharmaceutical chemicals proportion:
20 parts of Siraitia grosvenorii, 30 parts of peppermint, 20 parts of campanulaceae, 20 parts of Radix Glycyrrhizae, 10 parts of semen armeniacae amarae, 20 parts of instant Fruit powder, sugar alcohol (sorb 50 parts of sugar alcohol, 20 parts of mannitol), starch (40 parts of potato starch), and disintegrating agent (5 parts of sodium carboxymethyl starch, povidone 0.5 Part), sweetener (0.1 part of steviol glycoside, 0.05 part of Sucralose), 0.4 part of citric acid, 0.1 part of menthol.
Its preparation process includes the following steps:
A) peppermint is taken, is cleaned, 50 DEG C or less low temperature dryings are ground into 40-60 mesh powder, are obtained with supercritical carbon dioxide extracting Peppermint oil, peppermint oil are saved with cleaner, spare；Campanulaceae is cleaned, and 3-5mm sheet is cut into drying；Radix Glycyrrhizae is cleaned, and drying is cut At 3-5mm sheet；Semen armeniacae amarae is cleaned, and 50 DEG C or less low temperature dryings are ground into 11-20 mesh coarse grain；Siraitia grosvenorii is cleaned, drying, It is ground into 11-20 mesh coarse grain；Wherein, supercritical carbon dioxide extracting condition are as follows: extraction kettle pressure 25MPa separates I pressure 5MPa separates II pressure, 4 MPa, and extraction temperature is 45 DEG C, and I temperature of separation is 45 DEG C, and II temperature of separation is 35 DEG C, carbon dioxide Flow is 20 L/h, and extraction time is 2.5 hours；
B) peppermint after taking supercritical carbon dioxide extracting is added a) campanulaceae, Radix Glycyrrhizae, Siraitia grosvenorii, adds water to cook, water boiling After be added a) semen armeniacae amarae, decoct twice, for the first time plus 8 times of amount water, decoct 1.5 hours, second plus 6 times of amount water, decoction 1.5 hours, the immersion liquid for being 1.04 to relative density was concentrated under reduced pressure at 70 DEG C, is prepared using spray drying for filtration, merging filtrate Obtain mixed extract powder；
C) sugar alcohol, i.e. D-sorbite, mannitol are taken, 100 meshes are smashed it through, it is spare；Starch, i.e. potato starch are taken, crosses 100 It is spare after mesh；Instant Fruit powder is taken, it is spare after sieving with 100 mesh sieve；Citric acid is taken, it is spare after sieving with 100 mesh sieve；Take solid-like Menthol smashes it through 100 meshes, spare；
D) it takes the c) mannitol and 5 parts of potato starch to be uniformly mixed, obtains mixed powder, it is spare；
E) peppermint oil for taking step b) to obtain, is dissolved with ethyl alcohol, obtains solutions of mint oil, spare；
F) b) the mixed extract powder is taken, c) D-sorbite, instant Fruit powder, 35 parts of potato starch, lemons are added Lemon acid and menthol, disintegrating agent and sweetener, mix well, particle are prepared with Squeezinggranulator；
G) f) particle is placed on 80 mesh screens, takes the e) solutions of mint oil, be uniformly sprayed on particle surface, is holding Above the sieve of particle, by the mixed powder described in d), is shaken and be sieved by 100 mesh screens, uniformly to trickle down in particle surface, together When constantly shake sieve, so that particle is equably adsorbed mixed-powder, keep even particle size, surface smooth to get.
Embodiment 3:
Bulk pharmaceutical chemicals proportion:
40 parts of Siraitia grosvenorii, 40 parts of peppermint, 30 parts of campanulaceae, 50 parts of Radix Glycyrrhizae, 30 parts of semen armeniacae amarae, 30 parts of instant Fruit powder, sugar alcohol (sorb 60 parts of sugar alcohol, 10 parts of mannitol), starch (50 parts of potato starch), disintegrating agent (4 parts of sodium carboxymethyl starch, 1 part of povidone), Sweetener (0. 15 parts of steviol glycoside, 0.05 part of Sucralose), 0.4 part of citric acid, 0.1 part of menthol.
Its preparation process includes the following steps:
A) peppermint is taken, is cleaned, 50 DEG C or less low temperature dryings are ground into 40-60 mesh powder, are obtained with supercritical carbon dioxide extracting Peppermint oil, peppermint oil are saved with cleaner, spare；Campanulaceae is cleaned, and 3-5mm sheet is cut into drying；Radix Glycyrrhizae is cleaned, and drying is cut At 3-5mm sheet；Semen armeniacae amarae is cleaned, and 50 DEG C or less low temperature dryings are ground into 11-20 mesh coarse grain；Siraitia grosvenorii is cleaned, drying, It is ground into 11-20 mesh coarse grain；Wherein, supercritical carbon dioxide extracting condition are as follows: extraction kettle pressure 25MPa separates I pressure 10MPa separates II pressure 8MPa, and extraction temperature is 35 DEG C, and I temperature of separation is 45 DEG C, and II temperature of separation is 30 DEG C, carbon dioxide Flow is 30 L/h, and extraction time is 3 hours；
B) peppermint after taking supercritical carbon dioxide extracting is added a) campanulaceae, Radix Glycyrrhizae, Siraitia grosvenorii, adds water to cook, water boiling After be added a) semen armeniacae amarae, decoct twice, for the first time plus 10 times of amount water, decoct 2 hours, second plus 4 times of amount water, decoction 1 Hour, the immersion liquid for being 1.05 to relative density is concentrated under reduced pressure at 70 DEG C, is prepared into using spray drying for filtration, merging filtrate To mixed extract powder；
C) sugar alcohol, i.e. D-sorbite, mannitol are taken, 100 meshes are smashed it through, it is spare；Starch, i.e. potato starch are taken, crosses 100 It is spare after mesh；Instant Fruit powder is taken, it is spare after sieving with 100 mesh sieve；Citric acid is taken, it is spare after sieving with 100 mesh sieve；Take solid-like Menthol smashes it through 100 meshes, spare；
D) it takes the c) mannitol and 10 parts of potato starch to be uniformly mixed, obtains mixed powder, it is spare；
E) peppermint oil for taking step b) to obtain, is dissolved with ethyl alcohol, obtains solutions of mint oil, spare；
F) b) the mixed extract powder is taken, c) D-sorbite, instant Fruit powder, 40 parts of potato starch, lemons are added Lemon acid and menthol, disintegrating agent and sweetener, mix well, particle are prepared with Squeezinggranulator；
G) f) particle is placed on 80 mesh screens, takes the e) solutions of mint oil, be uniformly sprayed on particle surface, is holding Above the sieve of particle, by the mixed powder described in d), is shaken and be sieved by 100 mesh screens, uniformly to trickle down in particle surface, together When constantly shake sieve, so that particle is equably adsorbed mixed-powder, keep even particle size, surface smooth to get.
Comparative example 1:
Bulk pharmaceutical chemicals are matched with embodiment 1；
Its preparation process includes the following steps:
A) peppermint is taken, is cleaned, 50 DEG C or less low temperature dryings are ground into 40-60 mesh powder, spare；Campanulaceae is cleaned, and drying is cut into 3-5mm sheet；Radix Glycyrrhizae is cleaned, and 3-5mm sheet is cut into drying；Semen armeniacae amarae is cleaned, and 50 DEG C or less low temperature dryings are ground into 11- 20 mesh coarse grain；Siraitia grosvenorii is cleaned, and drying is ground into 11-20 mesh coarse grain；
B) a) peppermint, campanulaceae, Radix Glycyrrhizae, Siraitia grosvenorii are taken, is added water to cook, a) semen armeniacae amarae is added after water boiling, decocts two Secondary, for the first time plus 9 times of amount water, decoction 2 hours, second plus 5 times of amount water decoct 1 hour, filtration, merging filtrate, at 70 DEG C The immersion liquid that relative density is 1.06 is concentrated under reduced pressure, mixed extract powder is prepared using spray drying；
C) glycitols, i.e. D-sorbite, mannitol are taken, 100 meshes are smashed it through, it is spare；Starch, i.e. potato starch are taken, It is spare after sieving with 100 mesh sieve；Instant Fruit powder is taken, it is spare after sieving with 100 mesh sieve；Citric acid is taken, it is spare after sieving with 100 mesh sieve；It takes thin Lotus brain smashes it through 100 meshes, spare；
D) it takes c) mannitol and 10 parts of potato starch to be uniformly mixed, obtains mixed powder, it is spare；
E) b) the mixed extract powder is taken, c) D-sorbite, instant Fruit powder, 30 parts of potato starch, citric acids are added, And menthol, disintegrating agent and sweetener, it mixes well, particle is prepared with Squeezinggranulator；
F) e) particle is placed on 80 mesh screens, a small amount of ethanol solution is taken uniformly to be sprayed on particle surface, after will be d) described Mixed powder is equably sprinkled upon particle surface, and constantly shakes sieve, keep even particle size, surface smooth to get.
Comparative example 2:
Bulk pharmaceutical chemicals are matched with embodiment 1；
Its preparation process includes the following steps:
A) peppermint is taken, is cleaned, 50 DEG C or less low temperature dryings are ground into 40-60 mesh powder, are obtained with supercritical carbon dioxide extracting Peppermint oil, peppermint oil are saved with cleaner, spare；Campanulaceae is cleaned, and 3-5mm sheet is cut into drying；Radix Glycyrrhizae is cleaned, and drying is cut At 3-5mm sheet；Semen armeniacae amarae is cleaned, and 50 DEG C or less low temperature dryings are ground into 11-20 mesh coarse grain；Siraitia grosvenorii is cleaned, drying, It is ground into 11-20 mesh coarse grain；Wherein, supercritical carbon dioxide extracting condition are as follows: extraction kettle pressure 20MPa separates I pressure 8 MPa separates II pressure, 5 MPa, and extraction temperature is 40 DEG C, and I temperature of separation is 50 DEG C, and II temperature of separation is 30 DEG C, carbon dioxide Flow is 25 L/h, and extraction time is 2 hours；
B) peppermint after taking supercritical carbon dioxide extracting is added a) campanulaceae, Radix Glycyrrhizae, Siraitia grosvenorii, adds water to cook, water boiling After be added a) semen armeniacae amarae, decoct twice, for the first time plus 9 times of amount water, decoct 2 hours, second plus 5 times of amount water, decoction 1 is small When, the immersion liquid for being 1.06 to relative density is concentrated under reduced pressure at 70 DEG C, is prepared using spray drying for filtration, merging filtrate Mixed extract powder；
C) sugar alcohol, i.e. D-sorbite, mannitol are taken, 100 meshes are smashed it through, it is spare；Starch, i.e. potato starch are taken, crosses 100 It is spare after mesh；Instant Fruit powder is taken, it is spare after sieving with 100 mesh sieve；Citric acid is taken, it is spare after sieving with 100 mesh sieve；Menthol is taken, 100 meshes are smashed it through, it is spare；
D) peppermint oil for taking step b) to obtain, is dissolved with ethyl alcohol, obtains solutions of mint oil, spare；
E) take b) the mixed extract powder, be added c) D-sorbite, mannitol, instant Fruit powder, potato starch, Solutions of mint oil and menthol, disintegrating agent and sweetener described in citric acid and step d), mix well, use extrusion granulation Particle is prepared in machine.
40 volunteers that call-up age is 20-60 years old, respectively to instant profit prepared by embodiment 1-3, comparative example 1-2 Larynx particle carries out sense organ appraise, including comments its mouthfeel (sugariness and rear taste), flavor, refrigerant degree and throat effect of releiving etc. Point, it each 10 points, counts and calculates mean value；Measuring particle melting speed simultaneously, (the time required to entrance is completely dissolved, unit is Second), the cooling perception lasts time (unit is the second), hygroscopicity (placed in air for 24 hours after quality increase ratio, hereinafter referred to as quality increase Than) etc. every index；Experimental result is as follows:
By embodiment 1 compared with comparative example 1-2, peppermint raw material does not extract peppermint oil in advance in comparative example 1, directly decocts with raw material It boils, the particle sensory evaluation scores of preparation are lower, and the cooling perception lasts time is shorter；Peppermint oil is directly and mixed extract in comparative example 2 Powder and auxiliary material mixing granulation, the particle melting speed being prepared is slower, and hygroscopicity is stronger, quality after placing in air for 24 hours Increase than up to 37.85%；And particle sensory evaluation scores obtained by embodiment 1 are higher, and melting speed is very fast, entrance is completely dissolved Required time is 4.75s；The cooling perception lasts time is also longer, is 111.25 s；Hygroscopicity is weaker, matter after placing in air for 24 hours Amount increases than being 0.05%.
The present invention obtains through refining standby extract through water and adds using the natural integration of drinking and medicinal herbs medicinal material with pharynx-clearing throat-benefiting as raw material It adds in particle, particle is made to have the function of that throat discomfort of quickly and effectively releiving, peppermint raw material use supercritical extract side in advance Method extracts volatile oil, and peppermint oil is dissolved with a small amount of ethyl alcohol, is uniformly sprayed on particle surface, remains the spy of peppermint to the maximum extent Different fragrance, and enhance the refrigerant sense of particle；In addition, helping to adsorb in particle surface using solutions of mint oil as adhesive One layer, conducive to particle flash melt and the sugar alcohol powder of anti-moisture absorption, is released a large amount of heat, makes the refrigerant of particle when sugar alcohol dissolves Feel more longlasting, the anti-moisture absorption of potato starch and mannitol is preferable, it is ensured that particle is not easy the moisture absorption.

Claims (10)

  1. Exempt to rush throat soothing particle 1. one kind is instant, which is characterized in that be made of the raw material of following weight parts: 20-50 parts of Siraitia grosvenorii, thin 20-50 parts of lotus, 20-50 parts of campanulaceae, 20-50 parts of Radix Glycyrrhizae, 10-30 parts of semen armeniacae amarae, 10-100 parts of sugar alcohol, instant Fruit powder 20-40 Part, 30-100 parts of starch, 3-10 parts of disintegrating agent, 0.05-0.3 parts of sweetener, 0.1-0.8 parts of citric acid, menthol 0.05-0.4 Part.
  2. Exempt to rush throat soothing particle 2. one kind according to claim 1 is instant, which is characterized in that by the raw material system of following weight parts At: 30 parts of Siraitia grosvenorii, 40 parts of peppermint, 40 parts of campanulaceae, 35 parts of Radix Glycyrrhizae, 20 parts of semen armeniacae amarae, 80 parts of sugar alcohol, 30 parts of instant Fruit powder, 40 parts of starch, 5 parts of disintegrating agent, 0.2 part of sweetener, 0.6 part of citric acid, 0.3 part of menthol.
  3. Exempt to rush throat soothing particle 3. one kind according to claim 1 or 2 is instant, which is characterized in that the sugar alcohol be xylitol, One or more of D-sorbite, antierythrite or mannitol mixture；The instant Fruit powder is instant strawberry powder, instant One or more of honey peach powder, instant "Hami" melon powder or instant sweet orange powder mixture.
  4. Exempt to rush throat soothing particle 4. one kind according to claim 1 or 2 is instant, which is characterized in that the starch is solubility One or more of starch, water soluble starch, cornstarch or potato starch mixture；Preferably potato starch.
  5. Exempt to rush throat soothing particle 5. one kind according to claim 1 or 2 is instant, which is characterized in that the sweetener is stevia rebaudianum One or two kinds of mixtures in glucosides or Sucralose, the preferably mass ratio of steviol glycoside and Sucralose are 3:1.
  6. Exempt to rush throat soothing particle 6. one kind according to claim 1 or 2 is instant, which is characterized in that the disintegrating agent is carboxylic first One or more of mixtures in base sodium starch, povidone or carboxylic propyl methocel, preferably sodium carboxymethyl starch and poly- dimension The mass ratio of ketone is 4:1-5:0, more preferably 4:1.
  7. 7. the instant preparation method for exempting to rush throat soothing particle of one kind according to claim 1-6, which is characterized in that packet Include following steps:
    A) peppermint is taken, is cleaned, 50 DEG C or less low temperature dryings are ground into 40-60 mesh powder, are obtained with supercritical carbon dioxide extracting Peppermint oil, peppermint oil are saved with cleaner, spare；Campanulaceae is cleaned, and 3-5mm sheet is cut into drying；Radix Glycyrrhizae is cleaned, and drying is cut At 3-5mm sheet；Semen armeniacae amarae is cleaned, and 50 DEG C or less low temperature dryings are ground into 11-20 mesh coarse grain；Siraitia grosvenorii is cleaned, drying, It is ground into 11-20 mesh coarse grain；
    B) peppermint after taking supercritical carbon dioxide extracting is added a) campanulaceae, Radix Glycyrrhizae, Siraitia grosvenorii, adds water to cook, water boiling After be added a) semen armeniacae amarae, decoct twice, for the first time plus 8-10 times is measured water, is decocted 1-3 hour, add 4-6 times and measure water for second, It decocts 1-2 hours, filtration, merging filtrate, the immersion liquid for being 1.01-1.11 to relative density is concentrated under reduced pressure at 70 DEG C, using spray Mixed extract powder is prepared in mist drying；
    C) sugar alcohol is taken, 80-100 mesh is smashed it through, it is spare；Starch is taken, it is spare after crossing 80-100 mesh；Instant Fruit powder is taken, It is spare after sieving with 100 mesh sieve；Citric acid is taken, it is spare after crossing 80-100 mesh；Menthol is taken, 80-100 mesh is smashed it through, it is standby With；
    D) it takes c) part sugar alcohol and partial starch to be uniformly mixed, obtains mixed powder, it is spare；
    E) peppermint oil for taking step a) to obtain, is dissolved with ethyl alcohol, obtains solutions of mint oil, spare；
    F) it takes b) the mixed extract powder, c) remaining sugar alcohol, instant Fruit powder, remaining starch, citric acid and thin is added Lotus brain, disintegrating agent and sweetener, mix well, and particle is prepared with Squeezinggranulator；
    G) f) particle is placed on 80 mesh screens, takes the e) solutions of mint oil, be uniformly sprayed on particle surface, after will d) The mixed powder is equably sprinkled upon particle surface, keep even particle size, surface smooth to get.
  8. 8. the instant preparation method for exempting to rush throat soothing particle of one kind according to claim 7, which is characterized in that in step a), The supercritical carbon dioxide extracting condition are as follows: extraction kettle 20~25MPa of pressure separates I pressure, 5~10 MPa, II pressure of separation 4~8 MPa of power, extraction temperature are 35~45 DEG C, and I temperature of separation is 45~55 DEG C, and II temperature of separation is 30~35 DEG C, titanium dioxide Carbon flow is 20-30L/h, and extraction time is 1.5-3 hours.
  9. 9. the instant preparation method for exempting to rush throat soothing particle of one kind according to claim 8, which is characterized in that in step d), Starch is potato starch, 5-10 parts of additive amount；Sugar alcohol is mannitol, 10-20 parts of additive amount；In step f), starch Ma Ling Sweet potato starch, 30-40 parts of additive amount；Sugar alcohol is D-sorbite, and additive amount is 50-70 parts.
  10. 10. the instant preparation method for exempting to rush throat soothing particle of one kind according to claim 7, which is characterized in that in step g), Above the sieve for holding particle, the mixed powder described in d) is sieved by the concussion of 100 mesh screens, uniformly to trickle down in particle table Face, while sieve is constantly shaken, so that particle is equably adsorbed mixed-powder, keeps even particle size, surface smooth.
CN201811347209.XA 2018-11-13 2018-11-13 One kind is instant to be exempted to rush throat soothing particle and preparation method thereof Pending CN110313597A (en)

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CN112220822A (en) * 2020-10-30 2021-01-15 安徽世纪绿药生态农林有限公司 Kudzu root instant granules and preparation method thereof
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CN112823804A (en) * 2019-11-20 2021-05-21 石家庄以岭药业股份有限公司 Snow pear paste and preparation method thereof
CN112137097A (en) * 2020-10-10 2020-12-29 广东青云山药业有限公司 Oral instant granules and preparation method thereof
CN112220822A (en) * 2020-10-30 2021-01-15 安徽世纪绿药生态农林有限公司 Kudzu root instant granules and preparation method thereof

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