CN105079101A - Health care throat lozenge capable of clearing heat from throat and preparation method thereof - Google Patents
Health care throat lozenge capable of clearing heat from throat and preparation method thereof Download PDFInfo
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Abstract
The invention discloses health care throat lozenge capable of clearing heat from throat and a preparation method thereof. The throat lozenge contains the following substances: soluble starch, lactose, mannitol, sucrose, platycodon extract, terminalia chebula extract, momordica grosvenori extract, scaphium scaphigerum extract, lonicera japonica extract, arctium lappa extract, vitamin B1, mint camphor, borneol, 75% ethanol, eucalyptus oil, peppermint, PEG4000 and PEG6000. Compared with the prior art, the throat lozenge provided by the invention has the efficacies of clearing heat from throat, eliminating tumescence and killing pain, and can be used for preventing and treating sore throat, hoarseness, pharyngitis, throat abscess, acute tonsillitis, aphthous stomatitis, mouth and tongue sore, periodontalabscess, acute and chronic pharyngitis, tonsillitis, mouth ulcers, stomatitis, swelling and aching of gum and the like.
Description
Technical field
The present invention relates to a kind of throat lozenge, particularly a kind of pharynx-clearing throat-benefiting health throat lozenge and preparation method thereof.
Background technology
It is very many that the people of pharyngolaryngitis suffers from China, has a statistics to show, has the people of 70% to have laryngopharyngeal diseases symptom in various degree.Some specialties use sound personnel, and such as host, announcer, singer, performer, teacher etc., wherein teacher belongs to pharyngolaryngitis group of people at high risk.Did investigation in 2008, bottleneck throat inspection done to 3555 teachers, find to suffer from the middle of this troop of teacher pharyngolaryngitis up to 81.6%.For the people smoked, this numeral may be increased to more than 90%.We find clinically, the people of a lot of often smoking, and then speak aloud, if again with drinking, so more easily suffering from pharyngolaryngitis, adding and can not get good treatment for a long time, make its pharyngolaryngitis more serious.
In recent years, along with air environmental pollution, the sickness rate of chronic pharyngolaryngitis is in the trend risen year by year.Clinical main manifestations is pharyngeally have foreign body sensation, dryly itch or slightly cough, laryngopharynx swelling and pain, hoarseness and aphonia.Most of patients Relapse rate, brings larger impact to the work of people and life.Clinically desirable medicine be there is no to the treatment of chronic pharyngitis at present.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of pharynx-clearing throat-benefiting health throat lozenge, containing Radix Platycodonis, Fructus Chebulae, Semen Sterculiae Lychnophorae, Fructus Momordicae and Herba Menthae wet goods traditional Chinese medicine extraction component, mutual compatibility effect has extraordinary therapeutical effect for pharyngolaryngitis and caused various symptoms thereof.
Present invention also offers a kind of preparation method of pharynx-clearing throat-benefiting health throat lozenge, obtained throat lozenge is applicable to the symptoms such as pharyngolaryngitis.
A kind of pharynx-clearing throat-benefiting health throat lozenge, containing following material:
Described Radix Platycodonis extract prepares by the following method:
Take Radix Platycodonis appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 6-12 times of water gaging the 1st time, extracts 0.5-2h, add 4-10 times of water gaging 2nd time, extract 0.5-1.5h, add 3-8 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
Described Fructus Chebulae extract prepares by the following method:
Take Fructus Chebulae appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 6-12 times of water gaging the 1st time, extracts 0.5-2h, add 4-10 times of water gaging 2nd time, extract 0.5-1.5h, add 4-10 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
Described Fructus Momordicae extract prepares by the following method:
Take Fructus Momordicae appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 10-15 times of water gaging the 1st time, extracts 0.5-2h, add 8-12 times of water gaging 2nd time, extract 0.5-1.5h, add 8-12 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
Described Semen Sterculiae Lychnophorae extract prepares by the following method:
Take Semen Sterculiae Lychnophorae appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 20-30 times of water gaging the 1st time, extracts 0.5-2h, add 20-30 times of water gaging 2nd time, extract 0.5-1.5h, add 12-24 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
Described Flos Lonicerae extract prepares by the following method:
Take Flos Lonicerae appropriate, soak 0.15-0.8h, heating decocts extraction 3 times, add 12-24 times of water gaging 1st time, extract 0.5-2h, add 10-20 times of water gaging the 2nd time, extract 0.5-1.5h, add 10-18 times of water gaging the 3rd time, extract 0.5-1.5h, each filtration, merging filtrate, is concentrated into viscous pasty state, be placed in again and 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, and to obtain final product.
Described burdock extract prepares by the following method:
Take Fructus Arctii appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 6-12 times of water gaging the 1st time, extracts 0.5-2h, add 4-10 times of water gaging 2nd time, extract 0.5-1.5h, add 4-10 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
Present invention also offers a kind of preparation method of pharynx-clearing throat-benefiting health throat lozenge, comprise the following steps:
A) soluble starch 1-5g is taken successively, lactose 5-10g, mannitol 1-5g, sucrose 20-30g, Radix Platycodonis extract 0.5-3g, Fructus Chebulae extract 0.5-3g, Fructus Momordicae extract 0.5-3g, Semen Sterculiae Lychnophorae extract 0.2-2g, Flos Lonicerae extract 0.2-2g, burdock extract 0.2-2g, vitamin B
10.1-0.6g, sealing, mix homogeneously, forms Homogeneous phase mixing fine powder A;
B) take Mentholum 0.05-1g, Borneolum Syntheticum 0.05-1g, eucalyptus oil 0.2-2g, Oleum menthae 0.2-2g is dissolved in 3-6ml75% ethanol, forms solution B for subsequent use;
C) mixing fine powders A is added 6-12ml75% alcoholic solution, mixing, cross 10-16 mesh sieve manual expression and to sieve granulation, be placed in 40-60 DEG C of baking oven to dry, with 10-30 order, 40-80 mesh sieve granulate, by 10-30 mesh sieve, the granule not by 40-80 mesh sieve is wanted granule;
D) solution B being sprayed at step c equably) on the granule prepared, add PEG40000.3-1.2g, PEG60000.3-1.2g, mix homogeneously, namely upper tabletting machine obtains pharynx-clearing throat-benefiting health throat lozenge.
Various compositions in invention are as follows:
Radix Platycodonis has lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, laryngopharynx swelling and pain, aphonia.This product energy lung qi dispersing is let out evil in relieving sore throat to recover voice.All exopathogen violates lung, and pharyngalgia aphonia person, often joins the use such as Radix Glycyrrhizae, Fructus Arctii, as Radix Platycodonis decoction (" Medical Treasures of the Golden Chamber ") and add sweet in the mouth Fructus Citri tangerinae soup (" Medicine Comprehended ").Control laryngopharynx swelling and pain, pyretic toxicity Sheng person, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Radix Isatidis etc. can be joined with heat clearing away, removing toxic substances, sore-throat relieving.
Fructus Chebulae is warm in nature, and bitter in the mouth is sour and astringent, has relieving diarrhea with astringents, astringing lung-QI and relieving cough, effect of relieving sore throat to recover voice.This medicine is about 30%-40% containing tannin, and its main component is chebulinic acid, Chebulagic acid, gallic acid etc.Fructus Chebulae's soup in " Xuanming Lun Fang, Clear Synopsis on Recipes " that Liu Wansu shows is that principal agent treats aphonia with Fructus Chebulae, agraphia person.
Fructus Momordicae is sweet, cool, nontoxic, enters lung, spleen channel; there is effect of clearing away lung-heat to relieve cough, loosening bowel to relieve constipation; particularly effective to the tobacco and wine hoarseness, dry throat and mouth etc. caused such as excessive, throat can be protected, also can treat the diseases such as wind heat attacks hoarseness that lung causes, not well, the pharyngalgia of coughing.Can be used for treatment lung-fire cough caused by dryness, pharyngalgia aphonia.
Semen Sterculiae Lychnophorae character is cold and cool, acts on lung meridian, large intestine channel, has effect of clearing away lung-heat, throat, removing toxic substances.For lung-heat celostomia, to have sore throat and with diseases such as the throat hoarseness caused such as excessive.Life-time service can clearing throat, and can clear eliminating the pathogens from the lung heat, therefore is highly suitable for treating laryngopharynx swelling and pain.Make tea no matter alone, or coordinate the Chinese medicine with all the other heat-clearing and toxic substances removing, sore-throat relieving, all very effective.Semen Sterculiae Lychnophorae not only can clearing throat, and its use long can relieving sore throat to recover voice.
Flos Lonicerae sweet in the mouth, cold in nature, enter lung meridian, there is the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens, thin throat, relieving restlessness of relieving summer heat.Flos Lonicerae can also suppress and the pathogen killing throat, has infection effect to old man and child, often takes Flos Lonicerae and to soak or decoct is conducive to laryngopharynx swelling and pain, the treatment that influenza, furuncle toxic swelling, acute and chronic tonsillitis etc. are sick and rehabilitation.
Fructus Arctii has the effects such as dispelling wind sore-throat relieving, heat-clearing and toxic substances removing, lung qi dispersing rash, detumescence.Radix Arctii can be used for anemopyretic cold, cough, measles rubella, laryngopharynx swelling and pain.Describe in Compendium of Material Medica that Fructus Arctii is warm in nature, sweet in the mouth is nontoxic in detail.Can be used to make tea and drink.Burdock tea has the effect of extraordinary heat-clearing and toxic substances removing.
Oleum menthae acrid in the mouth, cool in nature, nontoxic.Oleum menthae pungent to disperse, cool to heat clearing away, clearly gently coolly to fall apart for the conventional product of dispelling wind and heat pathogens, there is wind-dispelling heat-dissipating, refresh oneself, throat, rash, effect of resolving depression, therefore wind heat table disease can be treated, have a headache dizzy, conjunctival congestion and swelling pain, the symptoms such as pharyngalgia celostomia.
Eucalyptus oil has special aroma, micro-like Camphora, acrid in the mouth, cool, and wind is antipyretic, damp eliminating removing toxic substances.Belong to pungent and cold medicine for relieving the exterior syndrome, can red swelling and pain of throat be alleviated.
Borneolum Syntheticum matter is crisp, gas fragrance, acrid in the mouth, cool, has the functions such as refreshment of having one's ideas straightened out, clearing heat for detumescence, pain relieving and controls throat ability to speak and newly swell and ache for a long time, and the pharynx of chronic cough phlegm-fire is mute has a pain.
In treatise on Febrile Diseases, once mentioned that Radix Platycodonis and Herba Menthae be used in conjunction can clearing throat, and wherein Radix Platycodonis plays main effect.In " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases ", also once mentioned Radix Platycodonis and Herba Menthae be used in conjunction this and act on, so the coupling of these two kinds of Chinese medicines has extraordinary therapeutic effect to pharyngolaryngitis and caused symptom thereof in the invention.On the books in ancient book, Semen Sterculiae Lychnophorae two, Radix Platycodonis 10g, decoct soup drink can lung reduce phlegm, sore-throat relieving, sound producing, Radix Platycodonis dispelling phlegm and relieving sore-throat, open sound, for cough due to lung-heat, pharyngalgia hoarseness.Fructus Momordicae and Herba Menthae coupling, effect that having promotes the production of body fluid moisturizes, sore-throat relieving wets one's whistle, to treatment pharyngolaryngitis, aphonia, summer-heat excessive thirst, phlegm-fire cough, etc. disease have extraordinary therapeutic effect.Ancient prescription is had to record, Flos Lonicerae 50g, RADIX PLATYCODI 30g, Herba Menthae 30g, Fructus Arctii 30g.Upper pestle is loose, often takes 30g, the decoction of fresh reed root soup.For cough, throat pruritus, aphonia etc., there is certain therapeutical effect.Can be good at alleviating pharyngolaryngitis and some caused symptoms thereof.Mention in " Xuanming Lun Fang, Clear Synopsis on Recipes " Fructus Chebulae soup, for aphonia agraphia person, Fructus Chebulae four (half big gun half a lifetime), Radix Platycodonis one or two (partly processing half a lifetime), two liang, Radix Glycyrrhizae (partly processing half a lifetime), upper decoct to five or seven with one, water with one, boy's urine to boil decoction being taken warmly for smalls often takes two money, to this symptom, there is extraordinary curative effect.
As seen from the above, the mutual compatibility effect in the present invention between various Chinese medicine has extraordinary therapeutical effect for pharyngolaryngitis and caused various symptoms thereof.So prescription of the present invention is the treatment being applicable to very much pharyngolaryngitis and symptom thereof.
Throat lozenge made by the present invention is light brown, and hardness, broken brittleness are suitable, and property of medicine gentleness does not stimulate, good stability, and taste is suitable for.For the protection of throat, pleasant throat, alleviates various throat discomfort symptom rapidly.
Compared with prior art, this throat lozenge has sore throat relieving sore-throat relieving in the present invention, reducing swelling and alleviating pain effect.For preventing and treating laryngopharynx swelling and pain, hoarseness, sore throat, retropharyngeal abscess, tonsillitis, erosion of the oral mucosa, aphtha of the mouth and tongue, gingival abscess, acute and chronic pharyngitis, tonsillitis, oral ulcer, stomatitis, gingival swelling and pain etc.
Detailed description of the invention:
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
A kind of pharynx-clearing throat-benefiting health throat lozenge, containing following material:
A preparation method for pharynx-clearing throat-benefiting health throat lozenge, comprises the following steps:
The preparation of 1.1 Radix Platycodonis extracts
Take Radix Platycodonis 100g, be ground into coarse powder, soak 0.5h, heating decocts extraction 3 times, adds 10 times of water gagings the 1st time, extracts 2h, add 8 times of water gagings 2nd time, extract 1h, add 6 times of water gagings the 3rd time, extract 0.5h, filter with 3 layers of gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 82 DEG C of water-baths steam to stagnant condition, be put in 44 DEG C of baking ovens and dry, pulverized 40 mesh sieves, stayed with for subsequent use.
The preparation of 1.2 Fructus Chebulae extracts
Take Fructus Chebulae 100g, be ground into coarse powder, soak 0.5h, heating decocts extracts, and extracts 3 times, adds 10 times of water yields the 1st time, extract 1.5h, the 2nd use 8 times of water yields, extract 1.5h, 3rd use, 8 times of water yields, extract 1h, filter at every turn with double gauze, merging filtrate, is concentrated into viscous pasty state, then is placed in 80 DEG C of water-baths steam to stagnant condition, be put in 40 DEG C of baking ovens and dry, pulverized 40 mesh sieves, stay with for subsequent use.
The preparation of 1.3 Fructus Momordicae extracts
Take Fructus Momordicae 90g, be ground into coarse powder, soak 0.4h, heating decocts extraction 3 times, the 1st use 10 times of water yields, extracts 1h, 2nd use, 8 times of water yields, extract 1h, the 3rd use 8 times of water yields, extract 0.5h, filter with double gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 85 DEG C of water-baths steam to stagnant condition, be put in 48 DEG C of baking ovens and dry, pulverized 50 mesh sieves, stayed with for subsequent use.
The preparation of 1.4 Semen Sterculiae Lychnophorae extracts
Take Semen Sterculiae Lychnophorae 100g, be ground into coarse powder, soak 0.3h, heating decocts extraction 3 times, the 1st use 30 times of water yields, extracts 1h, 2nd use, 25 times of water yields, extract 1h, the 3rd use 20 times of water yields, extract 0.5h, filter with two-layer gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 87 DEG C of water-baths steam to stagnant condition, be put in 49 DEG C of baking ovens and dry, pulverized 50 mesh sieves, stayed with for subsequent use.
The preparation of 1.5 Flos Lonicerae extracts
Take Flos Lonicerae 40g, soak 0.4h, heating decocts extraction 3 times, 1st use, 20 times of water yields, extract 1h, the 2nd use 18 times of water yields, extract 1h, the 3rd use 15 times of water yields, extract 0.5h, each use three layers of gauze filter, be concentrated into viscous pasty state, then be placed in 90 DEG C of water-baths steam to stagnant condition, be put in 50 DEG C of baking ovens and dry, pulverized 60 mesh sieves, stayed with for subsequent use.
The preparation of 1.6 burdock extracts
Take Fructus Arctii 60g, be ground into coarse powder, soak 0.3h, heating decocts extraction 3 times, the 1st use 8 times of water yields, extracts 1h, 2nd use, 6 times of water yields, extract 1h, the 3rd use 4 times of water yields, extract 0.5h, filter with three layers of gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 85 DEG C of water-baths steam to stagnant condition, be put in 55 DEG C of baking ovens and dry, pulverized 50 mesh sieves, stayed with for subsequent use.
The preparation of 1.7 throat lozenges
A) soluble starch 2g is taken successively, lactose 8g, mannitol 2g, sucrose 26g, Radix Platycodonis extract 1.2g, Fructus Chebulae extract 1.2g, Fructus Momordicae extract 1.2g, Semen Sterculiae Lychnophorae extract 0.4g, Flos Lonicerae extract 0.6g, burdock extract 0.6g, vitamin B
10.1g, is placed in sealing bag mix homogeneously, forms Homogeneous phase mixing fine powder A;
B) take Mentholum 0.2g, Borneolum Syntheticum 0.3g, eucalyptus oil 0.4g, Oleum menthae 0.4g is dissolved in 3ml75% ethanol, forms solution B for subsequent use;
C) mixing fine powders A is placed in pallet, add 6ml75% alcoholic solution, with hands rub to hold agglomerating one touch loose, cross 10 mesh sieve manual expression to sieve granulation, be placed in 40 DEG C of oven for drying, with 10 orders, 40 mesh sieve granulate, by 10 mesh sieves, the granule not by 40 mesh sieves is desired granule;
D) solution B be sprayed at equably on granule, add PEG40000.5g, PEG60000.7g, mix homogeneously, namely upper tabletting machine obtains pharynx-clearing throat-benefiting health throat lozenge.
Embodiment 2
A kind of pharynx-clearing throat-benefiting health throat lozenge, containing following material:
A preparation method for pharynx-clearing throat-benefiting health throat lozenge, comprises the following steps:
The preparation of 2.1 Radix Platycodonis extracts
Take Radix Platycodonis 100g, be ground into coarse powder, soak 0.5h, heating decocts extraction 3 times, adds 10 times of water gagings the 1st time, extracts 2h, add 8 times of water gagings 2nd time, extract 1h, add 6 times of water gagings the 3rd time, extract 0.5h, filter with 3 layers of gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 85 DEG C of water-baths steam to stagnant condition, be put in 50 DEG C of baking ovens and dry, pulverized 50 mesh sieves, stayed with for subsequent use.
The preparation of 2.2 Fructus Chebulae extracts
Take Fructus Chebulae 100g, be ground into coarse powder, soak 0.5h, heating decocts extracts, and extracts 3 times, adds 9 times of water yields the 1st time, extract 1.5h, the 2nd use 7 times of water yields, extract 1.5h, 3rd use, 10 times of water yields, extract 1h, filter at every turn with double gauze, merging filtrate, is concentrated into viscous pasty state, then is placed in 85 DEG C of water-baths steam to stagnant condition, be put in 55 DEG C of baking ovens and dry, pulverized 60 mesh sieves, stay with for subsequent use.
The preparation of 2.3 Fructus Momordicae extracts
Take Fructus Momordicae 90g, be ground into coarse powder, soak 0.3h, heating decocts extraction 3 times, the 1st use 10 times of water yields, extracts 1h, 2nd use, 8 times of water yields, extract 1h, the 3rd use 8 times of water yields, extract 0.5h, filter with double gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80 DEG C of water-baths steam to stagnant condition, be put in 45 DEG C of baking ovens and dry, pulverized 40 mesh sieves, stayed with for subsequent use.
The preparation of 2.4 Semen Sterculiae Lychnophorae extracts
Take Semen Sterculiae Lychnophorae 100g, be ground into coarse powder, soak 0.5h, heating decocts extraction 3 times, the 1st use 25 times of water yields, extracts 1h, 2nd use, 25 times of water yields, extract 1h, the 3rd use 22 times of water yields, extract 1h, filter with double gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 90 DEG C of water-baths steam to stagnant condition, be put in 75 DEG C of baking ovens and dry, pulverized 70 mesh sieves, stayed with for subsequent use.
The preparation of 2.5 Flos Lonicerae extracts
Take Flos Lonicerae 40g, soak 0.4h, heating decocts extraction 3 times, 1st use, 20 times of water yields, extract 1h, the 2nd use 18 times of water yields, extract 1h, the 3rd use 15 times of water yields, extract 0.5h, filter with double gauze, merging filtrate, is concentrated into viscous pasty state at every turn, be placed in again and 90 DEG C of water-baths steam to stagnant condition, be put in 70 DEG C of baking ovens and dry, pulverized 80 mesh sieves, stay with for subsequent use.
The preparation of 2.6 burdock extracts
Take Fructus Arctii 60g, be ground into coarse powder, soak 0.5h, heating decocts extraction 3 times, the 1st use 8 times of water yields, extracts 1h, 2nd use, 6 times of water yields, extract 1h, the 3rd use 4 times of water yields, extract 0.5h, filter with double gauze, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80 DEG C of water-baths steam to stagnant condition, be put in 60 DEG C of baking ovens and dry, pulverized 65 mesh sieves, stayed with for subsequent use.
The preparation of 2.7 throat lozenges
A) soluble starch 2g is taken successively, lactose 8g, mannitol 4g, sucrose 28g, Radix Platycodonis extract 2g, Fructus Chebulae extract 2g, Fructus Momordicae extract 1.5g, Semen Sterculiae Lychnophorae extract 0.6g, Flos Lonicerae extract 1g, burdock extract 0.8g, vitamin B
10.3g, is placed in sealing bag mix homogeneously, forms Homogeneous phase mixing fine powder A;
B) take Mentholum 0.2g, Borneolum Syntheticum 0.15g, eucalyptus oil 0.6g, Oleum menthae 0.6g is dissolved in 6ml75% ethanol, forms solution B for subsequent use;
C) mixing fine powders A is placed in pallet, add 12ml75% alcoholic solution, with hands rub to hold agglomerating one touch loose, cross 16 mesh sieve manual expression to sieve granulation, be placed in 60 DEG C of oven for drying, with 30 orders, 80 mesh sieve granulate, by 30 mesh sieves, the granule not by 80 mesh sieves is desired granule;
D) solution B be sprayed at equably on granule, add PEG40000.6g, PEG60000.6g, mix homogeneously, namely upper tabletting machine obtains pharynx-clearing throat-benefiting health throat lozenge.
Embodiment 3
A kind of pharynx-clearing throat-benefiting health throat lozenge, containing following material:
A preparation method for pharynx-clearing throat-benefiting health throat lozenge, comprises the following steps:
The preparation of 3.1 Radix Platycodonis extracts
Take Radix Platycodonis 80g, be ground into coarse powder, soak 0.3h, heating decocts extraction 3 times, adds 8 times of water gagings the 1st time, extracts 1h, add 6 times of water gagings 2nd time, extract 0.5h, add 5 times of water gagings the 3rd time, extract 0.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80 DEG C of water-baths steam to stagnant condition, be put in 50 DEG C of baking ovens and dry, pulverized 40 mesh sieves, stayed with for subsequent use.
The preparation of 3.2 Fructus Chebulae extracts
Take Fructus Chebulae 80g, be ground into coarse powder, soak 0.2h, heating decocts extraction 3 times, adds 8 times of water gagings the 1st time, extracts 1.5h, add 6 times of water gagings 2nd time, extract 1h, add 5 times of water gagings the 3rd time, extract 1.2h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 85 DEG C of water-baths steam to stagnant condition, be put in 50 DEG C of baking ovens and dry, pulverized 60 mesh sieves, stayed with for subsequent use.
The preparation of 3.3 Fructus Momordicae extracts
Take Fructus Momordicae 70g, be ground into coarse powder, soak 0.4h, heating decocts extraction 3 times, adds 10 times of water gagings the 1st time, extracts 2h, add 10 times of water gagings 2nd time, extract 1h, add 8 times of water gagings the 3rd time, extract 0.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 85 DEG C of water-baths steam to stagnant condition, be put in 55 DEG C of baking ovens and dry, pulverized 70 mesh sieves, stayed with for subsequent use.
The preparation of 3.4 Semen Sterculiae Lychnophorae extracts
Take Semen Sterculiae Lychnophorae 60g, be ground into coarse powder, soak 0.2h, heating decocts extraction 3 times, adds 25 times of water gagings the 1st time, extracts 1.5h, add 20 times of water gagings 2nd time, extract 1h, add 15 times of water gagings the 3rd time, extract 0.8h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 90 DEG C of water-baths steam to stagnant condition, be put in 70 DEG C of baking ovens and dry, pulverized 70 mesh sieves, stayed with for subsequent use.
The preparation of 3.5 Flos Lonicerae extracts
Take Flos Lonicerae 50g, soak 0.4h, heating decocts extraction 3 times, add 20 times of water gagings 1st time, extract 2h, add 15 times of water gagings the 2nd time, extract 1h, add 12 times of water gagings the 3rd time, extract 0.5h, each filtration, merging filtrate, is concentrated into viscous pasty state, be placed in again and 85 DEG C of water-baths steam to stagnant condition, be put in 60 DEG C of baking ovens and dry, pulverized 70 mesh sieves, stay with for subsequent use.
The preparation of 3.6 burdock extracts
Take Fructus Arctii 80g, be ground into coarse powder, soak 0.3h, heating decocts extraction 3 times, adds 6 times of water gagings the 1st time, extracts 1.2h, add 5 times of water gagings 2nd time, extract 1h, add 4 times of water gagings the 3rd time, extract 0.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80 DEG C of water-baths steam to stagnant condition, be put in 60 DEG C of baking ovens and dry, pulverized 60 mesh sieves, stayed with for subsequent use.
The preparation of 3.7 throat lozenges
A) soluble starch 3g is taken successively, lactose 5g, mannitol 3g, sucrose 25g, Radix Platycodonis extract 2g, Fructus Chebulae extract 1.5g, Fructus Momordicae extract 1.6g, Semen Sterculiae Lychnophorae extract 1g, Flos Lonicerae extract 0.5g, burdock extract 0.8g, vitamin B
10.3g, is placed in sealing bag mix homogeneously, forms Homogeneous phase mixing fine powder A;
B) take Mentholum 0.5g, Borneolum Syntheticum 0.6g, eucalyptus oil 0.8g, Oleum menthae 1g is dissolved in 5ml75% ethanol, forms solution B for subsequent use;
C) mixing fine powders A is placed in pallet, add 8ml75% alcoholic solution, with hands rub to hold agglomerating one touch loose, cross 15 mesh sieve manual expression to sieve granulation, be placed in 50 DEG C of oven for drying, with 20 orders, 50 mesh sieve granulate, by 20 mesh sieves, the granule not by 60 mesh sieves is desired granule;
D) solution B be sprayed at equably on granule, add PEG40000.8g, PEG60000.9g, mix homogeneously, namely upper tabletting machine obtains pharynx-clearing throat-benefiting health throat lozenge.
Embodiment 4
The index of embodiment 1,2,3 is as follows:
4.1 face shaping
Throat lozenge made by the present invention is sepia, complete bright and clean, uniform color, foreign, without assorted speckle.
4.2 uniformity of dosage units
Get the relative amount that ten measure every sheet respectively, determine whether certified products according to the method inspection of " Chinese Pharmacopoeia ", meet States Pharmacopoeia specifications on inspection.
4.3 weight differential
Get 20 to weigh, every blade is heavily compared with average sheet recast the tablet exceeding difference limit must not more than two panels, and must not have a slice to exceed overrun one times, meets States Pharmacopoeia specifications on inspection.
4.4 hardness and friability
Application Monsanto durometer method and sieve are permitted hardness and the friability that friability instrument method measures the throat lozenge made by the present invention respectively, meet States Pharmacopoeia specifications on inspection.
Embodiment 5
This throat lozenge resultant effect is investigated
Below utilize to try out and feel the effect carrying out the throat lozenge that Evaluation operation example 1,2,3 is produced.Adopt public-opinion poll point system, choose 80 25-50 year age bracket people as object on probation, be divided into arbitrarily two groups, respectively with throat lozenge prepared by embodiment 1,2.Every result of use total score is 5 points: 5 be divided into best result, represents very well, very satisfaction; 4 are divided into better; 3 are divided into and can accept; Less than 3 points is bad, can not accept.It is below every average.The results are shown in Table 1:
Table 1 resultant effect is investigated
In sum, made this throat lozenge of the present invention is complete bright and clean, uniform color, hardness and broken brittleness qualified, bright color, raciness, mouthfeel is good, and pharynx-clearing throat-benefiting, reducing swelling and alleviating pain, the sound producing that reduces phlegm are effective.
Claims (8)
1. a pharynx-clearing throat-benefiting health throat lozenge, is characterized in that, described pharynx-clearing throat-benefiting health throat lozenge contains following material:
2. pharynx-clearing throat-benefiting health throat lozenge according to claim 1, is characterized in that, described Radix Platycodonis extract prepares by the following method:
Take Radix Platycodonis appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 6-12 times of water gaging the 1st time, extracts 0.5-2h, add 4-10 times of water gaging 2nd time, extract 0.5-1.5h, add 3-8 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
3. pharynx-clearing throat-benefiting health throat lozenge according to claim 1, is characterized in that, described Fructus Chebulae extract prepares by the following method:
Take Fructus Chebulae appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 6-12 times of water gaging the 1st time, extracts 0.5-2h, add 4-10 times of water gaging 2nd time, extract 0.5-1.5h, add 4-10 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
4. pharynx-clearing throat-benefiting health throat lozenge according to claim 1, is characterized in that, described Fructus Momordicae extract prepares by the following method:
Take Fructus Momordicae appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 10-15 times of water gaging the 1st time, extracts 0.5-2h, add 8-12 times of water gaging 2nd time, extract 0.5-1.5h, add 8-12 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
5. pharynx-clearing throat-benefiting health throat lozenge according to claim 1, is characterized in that, described Semen Sterculiae Lychnophorae extract prepares by the following method:
Take Semen Sterculiae Lychnophorae appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 20-30 times of water gaging the 1st time, extracts 0.5-2h, add 20-30 times of water gaging 2nd time, extract 0.5-1.5h, add 12-24 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
6. pharynx-clearing throat-benefiting health throat lozenge according to claim 1, is characterized in that, described Flos Lonicerae extract prepares by the following method:
Take Flos Lonicerae appropriate, soak 0.15-0.8h, heating decocts extraction 3 times, add 12-24 times of water gaging 1st time, extract 0.5-2h, add 10-20 times of water gaging the 2nd time, extract 0.5-1.5h, add 10-18 times of water gaging the 3rd time, extract 0.5-1.5h, each filtration, merging filtrate, is concentrated into viscous pasty state, be placed in again and 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, and to obtain final product.
7. pharynx-clearing throat-benefiting health throat lozenge according to claim 1, is characterized in that, described burdock extract prepares by the following method:
Take Fructus Arctii appropriate, be ground into coarse powder, soak 0.15-0.8h, heating decocts extraction 3 times, adds 6-12 times of water gaging the 1st time, extracts 0.5-2h, add 4-10 times of water gaging 2nd time, extract 0.5-1.5h, add 4-10 times of water gaging the 3rd time, extract 0.5-1.5h, filter, merging filtrate at every turn, be concentrated into viscous pasty state, then be placed in 80-99 DEG C of water-bath steams to stagnant condition, be put in 40-80 DEG C of baking oven and dry, pulverized 40-80 mesh sieve, to obtain final product.
8. a preparation method for pharynx-clearing throat-benefiting health throat lozenge according to claim 1, it is characterized in that, described preparation method comprises the following steps:
A) soluble starch 1-5g is taken successively, lactose 5-10g, mannitol 1-5g, sucrose 20-30g, Radix Platycodonis extract 0.5-3g, Fructus Chebulae extract 0.5-3g, Fructus Momordicae extract 0.5-3g, Semen Sterculiae Lychnophorae extract 0.2-2g, Flos Lonicerae extract 0.2-2g, burdock extract 0.2-2g, vitamin B
10.1-0.6g, sealing, mix homogeneously, forms Homogeneous phase mixing fine powder A;
B) take Mentholum 0.05-1g, Borneolum Syntheticum 0.05-1g, eucalyptus oil 0.2-2g, Oleum menthae 0.2-2g is dissolved in 3-6ml75% ethanol, forms solution B for subsequent use;
C) mixing fine powders A is added 6-12ml75% alcoholic solution, mixing, cross 10-16 mesh sieve manual expression and to sieve granulation, be placed in 40-60 DEG C of baking oven to dry, with 10-30 order, 40-80 mesh sieve granulate, by 10-30 mesh sieve, the granule not by 40-80 mesh sieve is wanted granule;
D) solution B being sprayed at step c equably) on the granule prepared, add PEG40000.3-1.2g, PEG60000.3-1.2g, mix homogeneously, namely upper tabletting machine obtains pharynx-clearing throat-benefiting health throat lozenge.
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| CN110313597A (en) * | 2018-11-13 | 2019-10-11 | 广东一方制药有限公司 | One kind is instant to be exempted to rush throat soothing particle and preparation method thereof |
| CN110463877A (en) * | 2019-08-31 | 2019-11-19 | 会泽县恒易牧业有限公司 | A kind of health drink and preparation method thereof of anti-treating dental ulcer |
| CN114903820A (en) * | 2021-02-10 | 2022-08-16 | 伽蓝（集团）股份有限公司 | Composition containing myrobalan fruit extract and preparation method and application thereof |
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