CN101961388B - Balneation effervescent tablet for preventing heat type common cold - Google Patents
Balneation effervescent tablet for preventing heat type common cold Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal compound preparation, in particular to a bathing or footbath effervescent tablet for preventing heat type common cold, which consists of active ingredients, an effervescent excipient, an adhesive and a foaming agent. The effervescent tablet is characterized in that: the active ingredients are water extracts of the following crude medicaments in percentage by weight: 5 to 40 percent of fineleaf schizonepeta herb, 5 to 40 percent of kudzuvine root, 5 to 40 percent of Chinese thorowax root, 5 to 30 percent of wrinkled giantthyssop herb, 5 to 20 percent of baical skullcap root, 1 to 20 percent of lonicera flower and 1 to 20 percent of weeping forsythiae. The effervescent tablet of the invention has the effects of coursing wind, resolving the exterior, clearing heat, realizing detoxification and improving pyrexial headache caused by the cold by the mutual promotion and assistance of the seven crude medicaments in the complete recipe.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Flu is a kind of modal respiratory system disease, its be mainly in abrupt change of climate, cold warm not normal in, or because of daily life accidentally, unbalanced cold and heat, drench with rain, fatigue etc. makes the human body space between skin and muscles careless and sluggish, failure of defensive QI to protect the body against pathogen.Exopathogen is taken advantage of a weak point in opponent's defence invasion and attack and is caused a disease.The traditional Chinese medical science is divided into four types of wind-chill cold, common cold due to wind heat, summer-wet type common cold and influenzas (influenza) with flu.Anemopyretic cold also has that heating is heavy, thick sputum is yellow, sore throat except the general symptom that flu such as nasal obstruction, watery nasal discharge, cough, headache is arranged, pain just before cold symptoms usually, and expectorant is yellow usually, characteristics such as constipation.Treatment should be principle with relieving the exterior syndrome with drugs of pungent in flavor and cool in nature.At present, for anemopyretic cold, modern medicine is to its no better prevention way.Yet motherland's medical science has a remarkable advantages aspect the preventing and treating of flu: the one, prevent trouble before it happens, and because flu is multiple Disease Inducement, prevent the generation of catching a cold, can avoid other disease generation; The 2nd, check erroneous ideas at the outset---prevention makes flu gradually and not dark, and is little and not very, so favored by people.
The patent application of publication number CN1425449A " a kind of Chinese medicine composition for the treatment of anemopyretic cold and preparation method thereof " discloses a kind of oral formulations of being made by Radix Bupleuri, Flos Lonicerae, Radix Scutellariae, Radix Puerariae, Herba Schizonepetae, Herba Artemisiae Annuae, Fructus Forsythiae, Radix Platycodonis, Semen Armeniacae Amarum, Herba Menthae and Herba Houttuyniae.
The patent application of publication number CN1883651A " a kind of Chinese medicine composition for the treatment of anemopyretic cold and preparation method thereof " discloses a kind of oral formulations of being made by Radix Bupleuri, Radix Scutellariae, Gypsum Fibrosum, Herba Artemisiae Annuae, Radix Isatidis, Flos Lonicerae, Radix Et Rhizoma Rhei, Herba Taraxaci, the Rhizoma Anemarrhenae and Fructus Forsythiae.
The patent application of publication number CN101259197A " a kind of pharmaceutical composition for the treatment of flu and preparation method thereof " discloses a kind of oral formulations of being made by Flos Lonicerae, Radix Scutellariae, Herba Schizonepetae, Fructus Gardeniae, Fructus Forsythiae, Radix Scrophulariae, Bombyx Batryticatus, the Radix Rehmanniae, Rhizoma Belamcandae, Radix Platycodonis, Herba Menthae, Periostracum Cicadae, Radix Saposhnikoviae and Radix Glycyrrhizae.
The patent application of publication number CN101167898A " a kind of Chinese medicine for oral administration for the treatment of flu " discloses a kind of oral formulations of being made by Radix Bupleuri, Herba Moslae, Flos Lonicerae, Fructus Forsythiae, Cortex Magnoliae Officinalis, Seem Lablab Album, Herba Lophatheri, Herba Pogostemonis, Radix Scutellariae and Fructus Gardeniae.
The patent application of publication number CN101468156A " a kind of preparation method for the treatment of cold medicine " discloses a kind of oral tablet of being made by acetaminophen, Radix Platycodonis, Fructus Forsythiae, Semen Sojae Preparatum, Radix Glycyrrhizae, Herba Lophatheri, Flos Lonicerae, Fructus Arctii, Herba Schizonepetae and Mentholum.
The patent application of publication number CN1742956A " Lonicera and Forsythia effervescent " discloses a kind of oral administration effervescing sheet of being made by Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Semen Sojae Preparatum, Fructus Arctii, Radix Platycodonis, Herba Lophatheri and Radix Glycyrrhizae.
The patent application of publication number CN1903254A " compound medicine of treatment anemopyretic cold and preparation method thereof " discloses a kind of oral formulations of being made by Fructus Arctii, Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Radix Isatidis, Rhizoma Et Radix Notopterygii, Folium Isatidis and Radix Glycyrrhizae.
The patent application of publication number CN1293970A discloses a kind of " curing cold by omphalotherapy Chinese medicine preparation and production method thereof ", and wherein said preparation is directly pulverized by Flos Lonicerae, Fructus Forsythiae, Herba Artemisiae Annuae, Herba Schizonepetae, Herba Menthae, Radix Bupleuri, Herba Pogostemonis, Folium Artemisiae Argyi, Radix Platycodonis and Pericarpium Citri Reticulatae and made.
Though flu is a kind of commonly encountered diseases frequently-occurring disease, its risk factor is many and complicated, and the disease that is shown also is varied, therefore needs the advantage of performance Chinese medicine, develops the Chinese patent medicine of too many levels, multi-level, many target spots.
Summary of the invention
Technical problem to be solved by this invention provides a kind of shower or effervescence tablets for feet-washing that improves anemopyretic cold.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of shower or effervescence tablets for feet-washing that prevents anemopyretic cold, this effervescent tablet mainly is made up of active ingredient, effervescent excipient, binding agent and foaming agent, it is characterized in that described active ingredient is the water extract of following crude drug by weight percentage: Herba Schizonepetae 5%-40%, Radix Puerariae 5%-40%, Radix Bupleuri 5%-40%, Herba Pogostemonis 5%-30%, Radix Scutellariae 5%-20%, Flos Lonicerae 1%-20%, Fructus Forsythiae 1%-20%.
Shower of the present invention or effervescence tablets for feet-washing, wherein said active ingredient better are the water extracts of following crude drug by weight percentage: Herba Schizonepetae 10%-30%, Radix Puerariae 10%-30%, Radix Bupleuri 10%-30%, Herba Pogostemonis 10%-25%, Radix Scutellariae 5%-15%, Flos Lonicerae 2%-10%, Fructus Forsythiae 2%-10%; The water extract of following crude drug by weight percentage preferably: Herba Schizonepetae 24%, Radix Puerariae 23%, Radix Bupleuri 20%, Herba Pogostemonis 17%, Radix Scutellariae 10%, Flos Lonicerae 3%, Fructus Forsythiae 3%.
Shower of the present invention or effervescence tablets for feet-washing, wherein said active ingredient can adopt this area water extracting method commonly used to prepare, the method that the present invention recommends is as described below: get Herba Schizonepetae, Radix Puerariae, Radix Bupleuri, Herba Pogostemonis, Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, being concentrated into relative density is 1.28-1.32, makes extract powder after the drying.
Shower of the present invention or effervescence tablets for feet-washing, wherein said effervescent excipient is acid source and alkali source commonly used, wherein, described acid source is one or more in citric acid, tartaric acid, fumaric acid, adipic acid and the malic acid; Described alkali source is one or more in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and the calcium carbonate.Above-mentioned acid source is the best with citric acid or tartaric acid.Above-mentioned alkali source is the best with sodium carbonate, sodium bicarbonate or potassium bicarbonate.
Shower of the present invention or effervescence tablets for feet-washing, wherein said binding agent are a kind of or two or more in PEG4000～6000 of isopropyl alcohol, alcoholic solution and low relative molecular mass of hypromellose aqueous solution, PVP ethanol (water) solution, olefin(e) acid resin aqueous solution, starch slurry, ethanol, syrup, isopropyl alcohol, PEG (12000～20000).
Shower of the present invention or effervescence tablets for feet-washing, wherein said foaming agent are a kind of or two or more in tween 80, sodium lauryl sulphate and the hexadecanol.
Shower of the present invention or effervescence tablets for feet-washing, can also add the lubricant of being convenient to granulate according to the production technology needs, described lubricant is a kind of or two or more in Macrogol 4000, polyethylene glycol 6000, sodium lauryl sulphate, Stepanol MG, L-leucine, sodium benzoate, enuatrol, sodium chloride, sodium acetate, boric acid, magnesium stearate, Pulvis Talci, micropowder silica gel, sucrose fatty acid ester and the sodium stearyl fumarate.
Shower of the present invention or effervescence tablets for feet-washing can also add other adjuvant commonly used, as, filler, correctives, wherein, described filler is one or more in starch, microcrystalline Cellulose, dextrin lactose, mannitol, sucrose and the glucose; Described correctives is one or more in Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil, apple essence, flavoring orange essence, Oleum Anisi Stellati and the flavoring banana essence.
Shower of the present invention or effervescence tablets for feet-washing are a kind of pharmaceutical preparation commonly used, and the selection of its adjuvant and preparation method can be implemented with reference to " the technical study overview of Chinese medicine effervescent tablet " literary composition of " traditional medicine " 2008 the 17th volumes the 10th phase the 72nd page of publication.
The traditional Chinese medical science thinks, flu is because ailment said due to cold or exposure when taking advantage of human body to drive evil scarce capacity, and the invasion and attack lung is defended due to the fur.Since experience ailment said due to cold or exposure or the time row virus, cause that lung defends functional disorder, be a kind of exogenous diseases of main clinical manifestation with nasal obstruction, watery nasal discharge, sneeze, headache, aversion to cold, heating, general malaise.Wherein the main clinical manifestation of wind heat exterior syndrome is: yellow sputum, red tip of the tongue, yellow and thin fur, floating and rapid pulse etc. are coughed up in heating, aversion to cold, nasal obstruction watery nasal discharge, head-body-pain or thirsty, pharyngalgia, cough.Control suitable relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, the lung qi dispersing heat clearing away.The then suitable heat-clearing and toxic substances removing of influenza, diffusing lung, relieving exterior syndrome.
Active ingredient of the present invention is made by Flos Lonicerae, Fructus Forsythiae, Herba Schizonepetae, Radix Puerariae, Radix Scutellariae, Radix Bupleuri, Herba Pogostemonis etc., and its monarch drug is Flos Lonicerae, Fructus Forsythiae, Herba Schizonepetae, has heat-clearing and toxic substances removing, and the merit of the dispelling wind and heat pathogens that induces sweat cures mainly symptoms such as heating, aversion to cold, headache, pharyngalgia; Ministerial drug is Radix Bupleuri, Radix Puerariae, the energy reconciling superficies and interior, and expelling pathogenic factors from the exterior expels the heat-evil, and expelling pathogenic factors from muscles promotes the production of body fluid, and auxiliary monarch drug improves cold symptoms; Adjuvant drug is Herba Pogostemonis, Radix Scutellariae, the energy heat-clearing and toxic substances removing, and the removing dampness expelling summer-heat cooperates monarch-minister drug to improve symptoms such as nasal obstruction watery nasal discharge, head-body-pain, pharyngalgia.The seven flavor mutual reinforcements between of full side, Xiang Zuo reach dispelling wind to relieve the exterior syndrome, and heat-clearing and toxic substances removing improves the effect of cold, fever headache.
Shower of the present invention or effervescence tablets for feet-washing are put into water, under the effect of gas-producing disintegrant, at once producing a large amount of bubbles (carbon dioxide) rolls tablet up and down in water, quicken its disintegrate and thawing, and then make the rapid stripping of active ingredient in the tablet, when shower or foot care, but effective ingredient is Transdermal absorption both, but function is regulated in the holographic echo area of effective stimulus health again, and then realizes the purpose of prevention anemopyretic cold.
In order to understand the present invention better, clinical trial and the result with shower of the present invention or effervescence tablets for feet-washing prevention anemopyretic cold illustrates its effect below.
I, shower clinical experiment
One, physical data
All cases are the volunteer that anemopyretic cold is arranged repeatedly, male's 45 examples, age 18-45 year; Women's 45 examples, 18～45 years old age.Be divided into shower group 1,30 example (male 15 examples, women 15 examples) at random; Shower group 2,30 examples (male 15 examples, women 15 examples); Blank group 30 examples (male 15 examples, women 15 examples).The preceding 3 groups of data of taking a shower are learned processing by statistics, and difference there are no significant meaning (p＞0.05) has comparability.
Two. include standard in
The flu diagnosis is a foundation by " diagnostic criteria of the clinical research guideline of new Chinese medicine treatment flu ".Primary symptom: fever of the body is more outstanding, and micro evil wind, antiperspirant are let out not smooth, parched throat, or throat tonsillitis congestion and swelling pain, nasal obstruction, stream turbid nasal discharge, the floating number of pulse condition.Inferior disease: distending pain in the head, cough, expectorant is sticking or yellow, and thirst with desire to drink, thin lingual fur go out little Huang, and the limit point is red.
Three, exclusion standard:
(1) gestation and women breast-feeding their children.(2) psychotic.(3) merge to have the inclination, liver, renal function and the serious primary disease person of hemopoietic system.(4) used other treatment medicine person.(5) allergic constitution or to multiple drug allergy person.
Four, method
Shower group 1: the hot water of 1 of the effervescent tablet of embodiment 4 being put into 38～40 ℃ of 50-80 liters is taken a shower, and each 30 minutes, once a day, continuous 3 weeks.
Shower group 2: the hot water of 1 of the effervescent tablet of embodiment 7 being put into 38～40 ℃ of 50-80 liters is taken a shower, and each 30 minutes, once a day, continuous 3 weeks.
Blank group: the clear water with 38～40 ℃ of 50-80 liters is taken a shower, and each 30 minutes, once a day, continuous 3 weeks.
Five, observation of curative effect
Clinical symptoms standards of grading: volume of perspiration, pharyngalgia and nasal obstruction when observation index is mainly times of common cold, flu.At above clinical indices, respectively at before shower, the last back of taking a shower marks to the patient, Integral Rule is: do not have flu and counts 0 fen, have 1 flu to count 2 fens, have 2 flu to count 4 fens, having catches a cold more than 3 times counts 6 fens; No sweating is counted 0 fen, and slightly sweating is 1 minute, and sweating is counted 2 fens, and profuse perspiration is counted 3 fens; No pharyngalgia is counted 0 fen, and dry pharynx and micropain is counted 1 fen, and pharyngalgia is counted 2 fens, has sore throat and very counts 3 fens; Do not have nasal obstruction and count 0 fen, the sense of obstruction is arranged, low voice speaking is 1 minute, and nasal obstruction cuts in and out and counts 2 fens, and nasal obstruction continues not understand counts 3 fens.
Efficacy assessment standard: this standard reference " new Chinese medicine clinical research guideline " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value before the treatment-treatment back symptom integral value)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=30%;
Invalid: symptom is not seen obvious improvement or is instead seen deterioration, symptom integral value improvement rate＜30%.
Statistical procedures:
Total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after three groups of experimenters treated, and three groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test:
The clinical symptoms integration relatively sees Table 1 before and after shower group 1, shower group 2 and the blank group; Curative effect relatively sees Table 2-1,2-2; The improvement of cardinal symptom sign relatively sees Table 3-1,3-2.From table 2-1,2-2 as can be known, shower group 1, shower are organized 2 effects and are organized apparently higher than blank.N in the table 1 represents number.
Three groups of front and back clinical symptoms scorings relatively (x ± s, branch) of taking a shower of table 1
| Group | n | Before the treatment | After the treatment |
| Shower group 1 | 30 | 8.92±2.72 | 5.43±2.55a?b |
| Shower group 2 | 30 | 8.74±2.86 | 5.36±2.63a?b |
| Blank group | 30 | 8.95±3.11 | 7.91±2.98 |
Compare with the back of taking a shower before the shower: Pa＜0.05; The shower back is organized relatively with blank in shower group shower back: Pb＜0.05
Table 2-1 shower group 1 and blank group curative effect are relatively
Table 2-2 shower group 2 and blank group curative effect are relatively
Table 3-1 shower group 1 and blank group cardinal symptom sign are improved relatively
Compare with the back of taking a shower before the shower: Pa＜0.05; The shower back is organized relatively with blank in shower group shower back: Pb＜0.05
Table 3-2 shower group 2 and blank group cardinal symptom sign are improved relatively
Compare with the back of taking a shower before the shower: Pa＜0.05; The shower back is organized relatively with blank in shower group shower back: Pb＜0.05
II, foot care clinical experiment
One, physical data
All cases are the volunteer that anemopyretic cold is arranged repeatedly, male's 45 examples, age 18-45 year; Women's 45 examples, 18～45 years old age.Be divided into foot care group 1,30 example (male 15 examples, women 15 examples) at random; Foot care group 2,30 examples (male 15 examples, women 15 examples); Blank group 30 examples (male 15 examples, women 15 examples).Bathe foot care first three groups data and learn processing by statistics, difference there are no significant meaning (p＞0.05) has comparability.
Two. include standard in
The flu diagnosis is a foundation by " diagnostic criteria of the clinical research guideline of new Chinese medicine treatment flu ".Primary symptom: fever of the body is more outstanding, and micro evil wind, antiperspirant are let out not smooth, parched throat, or throat tonsillitis congestion and swelling pain, nasal obstruction, stream turbid nasal discharge, the floating number of pulse condition.Inferior disease: distending pain in the head, cough, expectorant is sticking or yellow, and thirst with desire to drink, thin lingual fur go out little Huang, and the limit point is red.
Three, exclusion standard:
(1) gestation and women breast-feeding their children.(2) psychotic.(3) merge to have the inclination, liver, renal function and the serious primary disease person of hemopoietic system.(4) used other treatment medicine person.(5) allergic constitution or to multiple drug allergy person.
Four, method
Foot care group 1: 1 of the effervescent tablet of embodiment 4 is put into 4 liters 38～40 ℃ hot water foot care, each 30 minutes, once a day, continuous 3 weeks.
Foot care group 2: 1 of the effervescent tablet of embodiment 7 is put into 4 liters 38～40 ℃ hot water foot care, each 30 minutes, once a day, continuous 3 weeks.
Blank group: with 4 liters 38～40 ℃ clear water foot care, each 30 minutes, once a day, continuous 3 weeks.
Five, observation of curative effect
Clinical symptoms standards of grading: volume of perspiration, pharyngalgia and nasal obstruction when observation index is mainly times of common cold, flu.At above clinical indices, respectively at before foot care, after the last foot care patient being marked, Integral Rule is: do not have flu and counts 0 fen: have 1 flu to count 2 fens, have 2 flu to count 4 fens, having catches a cold more than 3 times counts 6 fens; No sweating is counted 0 fen, and slightly sweating is 1 minute, and sweating is counted 2 fens, and profuse perspiration is counted 3 fens; No pharyngalgia is counted 0 fen, and dry pharynx and micropain is counted 1 fen, and pharyngalgia is counted 2 fens, has sore throat and very counts 3 fens; Do not have nasal obstruction and count 0 fen, the sense of obstruction is arranged, low voice speaking is 1 minute, and nasal obstruction cuts in and out and counts 2 fens, and nasal obstruction continues not understand counts 3 fens.
Efficacy assessment standard: this standard reference " new Chinese medicine clinical research guideline " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value before the treatment-treatment back symptom integral value)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=30%;
Invalid: symptom is not seen obvious improvement or is instead seen deterioration, symptom integral value improvement rate＜30%.
Statistical procedures:
Total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after three groups of experimenters treated, and three groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test:
The clinical symptoms integration relatively sees Table 4 before and after foot care group 1, foot care group 2 and the blank group; Curative effect relatively sees Table 5-1,5-2; The improvement of cardinal symptom sign relatively sees Table 6-1,6-2.From table 5-1,5-2 as can be known, foot care group 1, foot care group 2 effects are organized apparently higher than blank.N in the table represents number.
(x ± s divides) compared in the clinical symptoms scoring before and after three groups of foot cares of table 4
| Group | n | Before the treatment | After the treatment |
| Foot care group 1 | 30 | 9.37±2.68 | 5.87±2.41ab |
| Foot care group 2 | 30 | 9.19±2.69 | 5.81±2.46ab |
| Blank group | 30 | 9.40±2.94 | 8.36±2.83 |
Compare before the foot care with after the foot care: Pa＜0.05; Compare after the foot care of foot care group with after the foot care of blank group: Pb＜0.05
Table 5-1 foot care group 1 and blank group curative effect are relatively
Table 5-2 foot care group 2 and blank group curative effect are relatively
6-1 foot care group 1 and blank group cardinal symptom sign are improved relatively
Compare before the foot care with after the foot care: Pa＜0.05; Compare after the foot care of foot care group with after the foot care of blank group: Pb＜0.05
Table 6-2 foot care group 2 and blank group cardinal symptom sign are improved relatively
Compare before the foot care with after the foot care: Pa＜0.05; Compare after the foot care of foot care group with after the foot care of blank group: Pb＜0.05
The specific embodiment
Embodiment 1
Prescription:
Crude drug: Herba Schizonepetae 7000g, Radix Puerariae 7000g, Radix Bupleuri 6000g, Herba Pogostemonis 5000g, Radix Scutellariae 3000g, Flos Lonicerae 1000g, Fructus Forsythiae 1000g;
Adjuvant: citric acid 8000g (in anhydride), sodium bicarbonate 10100g, polyethylene glycol 6000 1200g, sodium lauryl sulphate 3450g, mannitol 1200g, EDTA-2NA 30g.
Method for making:
Above seven flavor medicine decocts with water secondary, adds 8 times of water gagings for the first time, adds 6 times of water gagings for the second time, and each 3 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), and 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, mannitol, polyethylene glycol 6000, EDTA-2NA, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 2
Prescription:
Crude drug: Herba Schizonepetae 7000g, Radix Puerariae 7000g, Radix Bupleuri 6000g, Herba Pogostemonis 5000g, Radix Scutellariae 3000g, Flos Lonicerae 1000g, Fructus Forsythiae 1000g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 7100g, sodium carbonate 3000g, polyethylene glycol 6000 3450g, Macrogol 4000 1230g.
Method for making:
More than seven flavors decoct with water secondary, add 10 times of water gagings for the first time, add 10 times of water gagings for the second time, each 3 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 3
Prescription:
Crude drug: Herba Schizonepetae 7000g, Radix Puerariae 7000g, Radix Bupleuri 6000g, Herba Pogostemonis 5000g, Radix Scutellariae 3000g, Flos Lonicerae 1000g, Fructus Forsythiae 1000g;
Adjuvant: citric acid 3000g (in anhydride), fumaric acid 5000g, sodium bicarbonate 5100g, sodium carbonate 5000g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3000g, mannitol 1680g, Oleum menthae (in right amount).
Method for making:
More than seven flavors decoct with water secondary, add 8 times of water gagings for the first time, add 8 times of water gagings for the second time, each 2 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, mannitol, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 4
Prescription:
Crude drug: Herba Schizonepetae 1500g, Radix Puerariae 1500g, Radix Bupleuri 1500g, Herba Pogostemonis 1500g, Radix Scutellariae 1500g, Flos Lonicerae 300g, Fructus Forsythiae 300g;
Adjuvant: citric acid 2000g (in anhydride), fumaric acid 6000g, potassium bicarbonate 5800g, potassium carbonate 4300g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 3000g, Pulvis Talci 450g, mannitol 1230g, Oleum menthae, Oleum Rosae Rugosae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 6 times of water gagings, add 6 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, potassium bicarbonate and potassium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds potassium bicarbonate and potassium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, spray into Oleum menthae, Oleum Rosae Rugosae, add polyethylene glycol 6000, Macrogol 4000, Pulvis Talci, mannitol, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 5
Prescription:
Crude drug: Herba Schizonepetae 1500g, Radix Puerariae 1500g, Radix Bupleuri 1500g, Herba Pogostemonis 1500g, Radix Scutellariae 1500g, Flos Lonicerae 300g, Fructus Forsythiae 300g;
Adjuvant: citric acid 8880g (in anhydride), calcium bicarbonate 10100g, Polyethylene Glycol 5000 4000g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 7 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, calcium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds the calcium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Be taken into Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 6
Prescription:
Crude drug: Herba Schizonepetae 1500g, Radix Puerariae 1500g, Radix Bupleuri 1500g, Herba Pogostemonis 1500g, Radix Scutellariae 1500g, Flos Lonicerae 300g, Fructus Forsythiae 300g;
Adjuvant: citric acid 4000g (in anhydride), fumaric acid 4000g, sodium bicarbonate 4100g, sodium carbonate 6000g, polyethylene glycol 6000 2400g, Polyethylene Glycol 5000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 9 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 7
Prescription:
Crude drug: Herba Schizonepetae 12000g, Radix Puerariae 12000g, Radix Bupleuri 12000g, Herba Pogostemonis 9000g, Radix Scutellariae 6000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 5800g, sodium carbonate 4300g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3450g, mannitol 1200g, EDTA-2NA 30g, Oleum menthae (in right amount).
Method for making:
Above seven flavor medicine material decocts with water secondary, adds 8 times of water gagings for the first time, adds 9 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, mannitol sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, and EDTA-2NA, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 8
Prescription:
Crude drug: Herba Schizonepetae 12000g, Radix Puerariae 12000g, Radix Bupleuri 12000g, Herba Pogostemonis 9000g, Radix Scutellariae 6000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 3000g, sodium carbonate 7100g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3000g, Pulvis Talci 450g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 7.5 times of water gagings, add 6.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 60 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, Pulvis Talci, mannitol sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 9
Prescription:
Crude drug: Herba Schizonepetae 12000g, Radix Puerariae 12000g, Radix Bupleuri 12000g, Herba Pogostemonis 9000g, Radix Scutellariae 6000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g;
Adjuvant: Oleum menthae (in right amount), citric acid 10100g (in anhydride), sodium bicarbonate 10400g, Polyethylene Glycol 5000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 9 times of water gagings, add 9 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 5000, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 10
Prescription:
Crude drug: Herba Schizonepetae 6000g, Radix Puerariae 6000g, Radix Bupleuri 6000g, Herba Pogostemonis 4500g, Radix Scutellariae 3000g, Flos Lonicerae 3000g, Fructus Forsythiae 3000g;
Adjuvant: citric acid 2000g (in anhydride), fumaric acid 6000g, sodium bicarbonate 3000g, sodium carbonate 7100g, polyethylene glycol 6000 4480g, Macrogol 4000 1400g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 11
Prescription:
Crude drug: Herba Schizonepetae 6000g, Radix Puerariae 6000g, Radix Bupleuri 6000g, Herba Pogostemonis 4500g, Radix Scutellariae 3000g, Flos Lonicerae 3000g, Fructus Forsythiae 3000g;
Adjuvant: citric acid 3450g (in anhydride), fumaric acid 8000g, sodium bicarbonate 2000g, sodium carbonate 8100g, polyethylene glycol 6000 1200g, Macrogol 4000 300g, sodium lauryl sulphate 100g, mannitol 800g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 7 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, mannitol sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, and mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 12
Prescription:
Crude drug: Herba Schizonepetae 6000g, Radix Puerariae 6000g, Radix Bupleuri 6000g, Herba Pogostemonis 4500g, Radix Scutellariae 3000g, Flos Lonicerae 3000g, Fructus Forsythiae 3000g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 1000g, sodium carbonate 9100g, polyethylene glycol 6000 1200g, Macrogol 4000 450g, sodium lauryl sulphate 3000g, Pulvis Talci 230g, mannitol 1000g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 7.5 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get sodium lauryl sulphate, Pulvis Talci sprays into Oleum menthae, adds polyethylene glycol 6000, Macrogol 4000, and mannitol, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 13
Prescription:
Crude drug: Herba Schizonepetae 1500g, Radix Puerariae 1500g, Radix Bupleuri 6000g, Herba Pogostemonis 5000g, Radix Scutellariae 3000g, Flos Lonicerae 1000g, Fructus Forsythiae 1000g;
Adjuvant: citric acid 9200g (in anhydride), sodium bicarbonate 11300g, polyethylene glycol 6000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 6 times of water gagings, add 7.5 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Be taken into polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 14
Prescription:
Crude drug: Herba Schizonepetae 1500g, Radix Puerariae 1500g, Radix Bupleuri 6000g, Herba Pogostemonis 5000g, Radix Scutellariae 3000g, Flos Lonicerae 1000g, Fructus Forsythiae 1000g;
Adjuvant: citric acid 4500g (in anhydride), fumaric acid 3500g, sodium bicarbonate 5000g, sodium carbonate 5100g, polyethylene glycol 6000 2400g, Macrogol 4000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 10 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 15
Prescription:
Crude drug: Herba Schizonepetae 1500g, Radix Puerariae 1500g, Radix Bupleuri 6000g, Herba Pogostemonis 5000g, Radix Scutellariae 3000g, Flos Lonicerae 1000g, Fructus Forsythiae 1000g;
Adjuvant: citric acid 6000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 6000g, sodium carbonate 4100g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 2480g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 7 times of water gagings, add 7.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 16
Prescription:
Crude drug: Herba Schizonepetae 7000g, Radix Puerariae 7000g, Radix Bupleuri 1500g, Herba Pogostemonis 1500g, Radix Scutellariae 1500g, Flos Lonicerae 300g, Fructus Forsythiae 300g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 5100g, sodium carbonate 5000g, polyethylene glycol 6000 1100g, Macrogol 4000 100g, sodium lauryl sulphate 3450g, Pulvis Talci 30g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 10 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 17
Prescription:
Crude drug: Herba Schizonepetae 7000g, Radix Puerariae 7000g, Radix Bupleuri 1500g, Herba Pogostemonis 1500g, Radix Scutellariae 1500g, Flos Lonicerae 300g, Fructus Forsythiae 300g;
Adjuvant: Oleum menthae (in right amount), citric acid 10400g (in anhydride), sodium bicarbonate 10100g, polyethylene glycol 6000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 9.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 18
Prescription:
Crude drug: Herba Schizonepetae 7000g, Radix Puerariae 7000g, Radix Bupleuri 1500g, Herba Pogostemonis 1500g, Radix Scutellariae 1500g, Flos Lonicerae 300g, Fructus Forsythiae 300g;
Adjuvant: citric acid 5000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 4100g, sodium carbonate 6000g, polyethylene glycol 6000 2400g, Macrogol 4000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 70 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 19
Prescription:
Crude drug: Herba Schizonepetae 6000g, Radix Puerariae 6000g, Radix Bupleuri 12000g, Herba Pogostemonis 9000g, Radix Scutellariae 6000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g;
Adjuvant: citric acid 1000g (in anhydride), fumaric acid 7000g, sodium bicarbonate 9000g, sodium carbonate 1100g, polyethylene glycol 6000 1200g, Macrogol 4000 480g, sodium lauryl sulphate 3000g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 20
Prescription:
Crude drug: Herba Schizonepetae 6000g, Radix Puerariae 6000g, Radix Bupleuri 12000g, Herba Pogostemonis 9000g, Radix Scutellariae 6000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g;
Adjuvant: citric acid 4000g (in anhydride), fumaric acid 4000g, sodium bicarbonate 2000g, sodium carbonate 8100g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 3450g, Pulvis Talci 30g mannitol 1200g Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 21
Prescription:
Crude drug: Herba Schizonepetae 6000g, Radix Puerariae 6000g, Radix Bupleuri 12000g, Herba Pogostemonis 9000g, Radix Scutellariae 6000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g;
Adjuvant: citric acid 11000g (in anhydride), sodium bicarbonate 12500g, polyethylene glycol 6000 1680g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 9 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 22
Prescription:
Crude drug: Herba Schizonepetae 12000g, Radix Puerariae 12000g, Radix Bupleuri 6000g, Herba Pogostemonis 4500g, Radix Scutellariae 3000g, Flos Lonicerae 3000g, Fructus Forsythiae 3000g;
Adjuvant: citric acid 7000g (in anhydride), fumaric acid 1000g, sodium bicarbonate 4800g, sodium carbonate 5300g, polyethylene glycol 6000 2400g, Macrogol 4000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 9.5 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 23
Prescription:
Crude drug: Herba Schizonepetae 12000g, Radix Puerariae 12000g, Radix Bupleuri 6000g, Herba Pogostemonis 4500g, Radix Scutellariae 3000g, Flos Lonicerae 3000g, Fructus Forsythiae 3000g;
Adjuvant: citric acid 8000g (in anhydride), fumaric acid 6000g, sodium bicarbonate 4000g, sodium carbonate 8000g, polyethylene glycol 6000 1000g, Macrogol 4000 300g, sodium lauryl sulphate 1450g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 24
Prescription:
Crude drug: Herba Schizonepetae 12000g, Radix Puerariae 12000g, Radix Bupleuri 6000g, Herba Pogostemonis 4500g, Radix Scutellariae 3000g, Flos Lonicerae 3000g, Fructus Forsythiae 3000g;
Adjuvant: citric acid 7000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 7000g, sodium carbonate 3000g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 1450g, Pulvis Talci 130g, mannitol 1100g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 25
Prescription:
Crude drug: Herba Schizonepetae 6000g, Radix Puerariae 6000g, Radix Bupleuri 12000g, Herba Pogostemonis 5000g, Radix Scutellariae 3000g, Flos Lonicerae 1000g, Fructus Forsythiae 1000g;
Adjuvant: citric acid 9200g (in anhydride), sodium bicarbonate 11300g, polyethylene glycol 6000 3480g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 6.5 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 87 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 26
Prescription:
Crude drug: Herba Schizonepetae 12000g, Radix Puerariae 12000g, Radix Bupleuri 6000g, Herba Pogostemonis 1500g, Radix Scutellariae 1500g, Flos Lonicerae 300g, Fructus Forsythiae 300g;
Adjuvant: citric acid 8000g (in anhydride), fumaric acid 1480g, sodium bicarbonate 5100g, sodium carbonate 7000g, polyethylene glycol 6000 1000g, Macrogol 4000 200g.
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 27
Prescription:
Crude drug: Herba Schizonepetae 1500g, Radix Puerariae 1500g, Radix Bupleuri 6000g, Herba Pogostemonis 9000g, Radix Scutellariae 6000g, Flos Lonicerae 6000g, Fructus Forsythiae 6000g;
Adjuvant: citric acid 8000g (in anhydride), fumaric acid 3000g, sodium bicarbonate 7800g, sodium carbonate 2300g, polyethylene glycol 6000 1000g, Macrogol 4000 200g, sodium lauryl sulphate 480g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 95 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Embodiment 28
Prescription:
Crude drug: Herba Schizonepetae 7000g, Radix Puerariae 7000g, Radix Bupleuri 1500g, Herba Pogostemonis 4500g, Radix Scutellariae 3000g, Flos Lonicerae 3000g, Fructus Forsythiae 3000g;
Adjuvant: citric acid 6000g (in anhydride), fumaric acid 2000g, sodium bicarbonate 5000g, sodium carbonate 5100g, polyethylene glycol 6000 900g, Macrogol 4000 300g, sodium lauryl sulphate 3000g, Pulvis Talci 480g, mannitol 1200g, Oleum menthae (in right amount).
Method for making:
More than seven flavor crude drug decoct with water secondary, add for the first time 8 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Taking polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, mannitol, mixing sprays into Oleum menthae, crosses 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000.
Claims (4)
1. a shower or effervescence tablets for feet-washing that prevents anemopyretic cold, this effervescent tablet is made up of effective ingredient, acid source, alkali source, binding agent and foaming agent, it is characterized in that described effective ingredient is the water extract of following crude drug by weight percentage: Herba Schizonepetae 5%-40%, Radix Puerariae 5%-40%, Radix Bupleuri 5%-40%, Herba Pogostemonis 5%-30%, Radix Scutellariae 5%-20%, Flos Lonicerae 1%-20%, Fructus Forsythiae 1%-20%.
2. a kind of shower or effervescence tablets for feet-washing that prevents anemopyretic cold according to claim 1, it is characterized in that, described effective ingredient is the water extract of following crude drug by weight percentage: Herba Schizonepetae 10%-30%, Radix Puerariae 10%-30%, Radix Bupleuri 10%-30%, Herba Pogostemonis 10%-25%, Radix Scutellariae 5%-15%, Flos Lonicerae 2%-10%, Fructus Forsythiae 2%-10%.
3. a kind of shower or effervescence tablets for feet-washing that prevents anemopyretic cold according to claim 2 is characterized in that described effective ingredient is the water extract of following crude drug by weight percentage: Herba Schizonepetae 24%, Radix Puerariae 23%, Radix Bupleuri 20%, Herba Pogostemonis 17%, Radix Scutellariae 10%, Flos Lonicerae 3%, Fructus Forsythiae 3%.
4. according to claim 1,2 or 3 described a kind of shower or effervescence tablets for feet-washing that prevent anemopyretic cold, it is characterized in that, described water extract is prepared by following method: get Herba Schizonepetae, Radix Puerariae, Radix Bupleuri, Herba Pogostemonis, Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, being concentrated into relative density is 1.28-1.32, makes extract powder after the drying.
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| CN2010102825528A CN101961388B (en) | 2010-09-14 | 2010-09-14 | Balneation effervescent tablet for preventing heat type common cold |
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| CN2010102825528A CN101961388B (en) | 2010-09-14 | 2010-09-14 | Balneation effervescent tablet for preventing heat type common cold |
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| CN101961388B true CN101961388B (en) | 2011-11-30 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103083584A (en) * | 2011-11-04 | 2013-05-08 | 陈良鉴 | Traditional Chinese medicine for treating influenza |
| CN103316117B (en) * | 2012-03-21 | 2017-05-03 | 广东畜宝生物科技有限公司 | Chinese medicinal composition for prevention and treatment of swine high fever syndrome |
| CN103830633B (en) * | 2014-03-27 | 2016-04-13 | 青岛崂好人海洋生物技术有限公司 | A kind of algae health preserving powder for dipping feet |
| CN106466388A (en) * | 2015-08-20 | 2017-03-01 | 哈尔滨灵草舒生物科技有限公司 | A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof |
| CN112843184A (en) * | 2020-12-10 | 2021-05-28 | 石门县中医医院 | Pharmaceutical composition for treating wind-heat type common cold and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN101474286A (en) * | 2008-01-03 | 2009-07-08 | 原明星 | Tablet for treating common cold |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
| CN101474286A (en) * | 2008-01-03 | 2009-07-08 | 原明星 | Tablet for treating common cold |
Non-Patent Citations (1)
| Title |
|---|
| 张灿玾.感冒病证治浅见.《天津中医药》.2010,第27卷(第1期),第1-4页. * |
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